chloroprocaine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
local anaesthetics 605 133-16-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • chloroprocaine
  • chloroprocain
  • chlorprocaine
  • piocaine
  • halestyn
  • chloroprocaine hydrochloride
  • chloroprocaine HCl
  • Molecular weight: 270.76
  • Formula: C13H19ClN2O2
  • CLOGP: 2.91
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 55.56
  • ALOGS: -2.32
  • ROTB: 7

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 11, 1955 FDA FRESENIUS KABI USA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01BA04 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, LOCAL
Esters of aminobenzoic acid
FDA EPC N0000175683 Ester Local Anesthetic
FDA Chemical/Ingredient N0000166743 Esters
FDA PE N0000175976 Local Anesthesia
MeSH PA D000777 Anesthetics
CHEBI has role CHEBI:36333 local anaesthetic
CHEBI has role CHEBI:49110 peripheral nervous system drug
CHEBI has role CHEBI:35488 central nervous system depressant
MeSH PA D000779 Anesthetics, Local
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Local anesthesia indication 386761002
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Disease of liver contraindication 235856003 DOID:409
Deficiency of cholinesterase contraindication 360607009

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.8 Basic
pKa2 2.01 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
50MG/5ML (10MG/ML) CLOROTEKAL B BRAUN MEDICAL INC N208791 Sept. 26, 2017 RX SOLUTION INTRATHECAL 8969412 Sept. 5, 2026 A METHOD FOR INDUCING A REGIONAL ANAESTHESIA VIA INTRATHECAL ADMINISTRATION OF A PATENTED PRESERVATIVE FREE SOLUTION FOR INJECTION (WITH A SPECIFIC COMPOSITION, PH, OSMOLALITY AND DENSITY) CONTAINING 9-11 MG/ML CHLOROPROCAINE HCL

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
50MG/5ML (10MG/ML) CLOROTEKAL B BRAUN MEDICAL INC N208791 Sept. 26, 2017 RX SOLUTION INTRATHECAL Sept. 26, 2020 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel protein type 10 subunit alpha Ion channel BLOCKER DRUGBANK CHEMBL

External reference:

IDSource
4019674 VUID
N0000179078 NUI
C0055443 UMLSCUI
D00732 KEGG_DRUG
5YVB0POT2H UNII
487 INN_ID
370295004 SNOMEDCT_US
4019674 VANDF
004566 NDDF
d01395 MMSL
20859 RXNORM
71668006 SNOMEDCT_US
CHEBI:3636 CHEBI
CHEMBL944 ChEMBL_ID
CHEMBL1179047 ChEMBL_ID
3858-89-7 SECONDARY_CAS_RN
DB01161 DRUGBANK_ID
7145 IUPHAR_LIGAND_ID
8612 PUBCHEM_CID
C004616 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Chloroprocaine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9209 INJECTION, SOLUTION 20 mg EPIDURAL ANDA 12 sections
Chloroprocaine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9210 INJECTION, SOLUTION 30 mg EPIDURAL ANDA 12 sections
Clorotekal HUMAN PRESCRIPTION DRUG LABEL 1 0264-7055 INJECTION, SOLUTION 10 mg INTRATHECAL NDA 17 sections
CHLOROPROCAINE HCI HUMAN PRESCRIPTION DRUG LABEL 1 51662-1401 INJECTION, SOLUTION 20 mg INFILTRATION NDA 13 sections
(CHLOROPROCAINE HCI HUMAN PRESCRIPTION DRUG LABEL 1 51662-1407 INJECTION, SOLUTION 10 mg INFILTRATION NDA 13 sections
CHLOROPROCAINE HCI HUMAN PRESCRIPTION DRUG LABEL 1 51662-1408 INJECTION, SOLUTION 20 mg INFILTRATION NDA 13 sections
Nesacaine HUMAN PRESCRIPTION DRUG LABEL 1 52584-475 INJECTION, SOLUTION 10 mg INFILTRATION NDA 12 sections
NESACAINE HUMAN PRESCRIPTION DRUG LABEL 1 52584-476 INJECTION, SOLUTION 20 mg INFILTRATION NDA 12 sections
Nesacaine HUMAN PRESCRIPTION DRUG LABEL 1 63323-475 INJECTION, SOLUTION 10 mg INFILTRATION NDA 13 sections
Nesacaine HUMAN PRESCRIPTION DRUG LABEL 1 63323-476 INJECTION, SOLUTION 20 mg INFILTRATION NDA 13 sections
Nesacaine HUMAN PRESCRIPTION DRUG LABEL 1 63323-477 INJECTION, SOLUTION 20 mg INFILTRATION NDA 13 sections
Nesacaine HUMAN PRESCRIPTION DRUG LABEL 1 63323-478 INJECTION, SOLUTION 30 mg INFILTRATION NDA 13 sections