teceleukin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
interleukin-2 analogues and derivatives	5484	136279-32-8

Description:

Molecule

Description

Synonyms:

teceleukin
teceleukin (genetical recombination)
imunace
BG 8301
bioleukin
S-6820

a recombinant IL-2 product having a methionine added at the N-terminal.

Molecular weight: 15547.22
Formula: C698H1127N179O204S8
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 6216.69
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 31, 1992	PMDA	SHIONOGI & Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoalbuminaemia	93.79	74.09	21	469	11784	63476748

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoalbuminaemia	68.23	61.35	18	424	12156	34944333

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoalbuminaemia	141.85	69.13	36	953	21261	79722138
Aspartate aminotransferase increased	114.62	69.13	48	941	138593	79604806
Alanine aminotransferase increased	85.30	69.13	41	948	162529	79580870
Gamma-glutamyltransferase increased	81.00	69.13	29	960	54651	79688748
Face oedema	78.18	69.13	24	965	28112	79715287
Pyrexia	71.71	69.13	62	927	678647	79064752

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Enhancement of an antitumor effect of dinutuximab for neuroblastoma	indication	432328008	DOID:769

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Interleukin-2 receptor	Membrane receptor	P01589 P14784 P31785	IL2RA_HUMAN IL2RB_HUMAN IL2RG_HUMAN	BINDING AGENT				UNKNOWN	KEGG DRUG

External reference:

ID	Source
CHEMBL2107892	ChEMBL_ID
DB15389	DRUGBANK_ID
D02749	KEGG_DRUG
C2825351	UMLSCUI
5838	INN_ID
65181	PUBCHEM_CID
H5ZRB188EI	UNII

Pharmaceutical products:

None