volanesorsen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antisense oligonucleotides 5335 915430-78-3

Description:

MoleculeDescription

Synonyms:

  • volanesorsen
  • volanesorsen sodium
  • waylivra
  • IONIS-304801
  • IONIS-APOCIII
  • IONIS-APOCIIIRx
Volanesorsen is an antisense oligonucleotide designed to inhibit the formation of apoC-III, a protein that is recognised to regulate both triglyceride metabolism and hepatic clearance of chylomicrons and other triglyceride-rich lipoproteins. The selective binding of volanesorsen to the apoC-III messenger ribonucleic acid (mRNA) within the 3′ untranslated region at base position 489-508 causes the degradation of the mRNA. This binding prevents translation of the protein apoC-III, thus removing an inhibitor of triglyceride clearance and enabling metabolism through an LPL-independent pathway
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 3, 2019 EMA Akcea Therapeutics Ireland Limited

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C10AX18 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
Other lipid modifying agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Chylomicronemia syndrome indication 402786009
Thrombocytopenic disorder contraindication 302215000 DOID:1588




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
apolipoprotein C-III (apoC-III) mRNA RNA ANTISENSE INHIBITOR UNKNOWN DRUG LABEL

External reference:

IDSource
2O4BE0K238 UNII
C4726970 UMLSCUI
CHEMBL3544994 ChEMBL_ID
121494123 PUBCHEM_CID
DB15067 DRUGBANK_ID
CHEMBL3544989 ChEMBL_ID
8681 IUPHAR_LIGAND_ID
37541 MMSL
018803 NDDF
018804 NDDF
C000593612 MESH_SUPPLEMENTAL_RECORD_UI
10166 INN_ID
1573402-50-2 SECONDARY_CAS_RN

Pharmaceutical products:

None