etanercept 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Tumour Necrosis Factor (TNF) receptors 4978 185243-69-0

Description:

MoleculeDescription

Synonyms:

  • etanercept-szzs
  • erelzi
  • etanercept
  • enbrel
  • TNR 001
  • TNR-001
  • etanercept (genetical recombination)
A recombinant version of soluble human TNF receptor fused to an IgG FC fragment that binds specifically to TUMOR NECROSIS FACTOR and inhibits its binding with endogenous TNF receptors. It prevents the inflammatory effect of TNF and is used to treat RHEUMATOID ARTHRITIS; PSORIATIC ARTHRITIS and ANKYLOSING SPONDYLITIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
7 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 19, 2005 PMDA WYETH LEDERLE JAPAN, WYETH
Nov. 2, 1998 FDA IMMUNEX
Feb. 3, 2000 EMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Injection site pain 40051.77 13.41 24626 864790 86398 49629310
Injection site erythema 39913.08 13.41 21437 867979 53499 49662209
Injection site pruritus 22363.84 13.41 11879 877537 28532 49687176
Injection site swelling 21536.25 13.41 11715 877701 30058 49685650
Injection site reaction 16858.38 13.41 10655 878761 39377 49676331
Injection site bruising 13294.71 13.41 8193 881223 28575 49687133
Injection site warmth 11713.28 13.41 5440 883976 8426 49707282
Drug ineffective 9098.06 13.41 33156 856260 786177 48929531
Injection site rash 6767.44 13.41 3962 885454 12215 49703493
Arthralgia 6259.60 13.41 19369 870047 419333 49296375
Injection site urticaria 5594.53 13.41 3174 886242 9043 49706665
Wrong technique in product usage process 5443.62 13.41 5753 883663 49757 49665951
Injection site haemorrhage 5384.86 13.41 3802 885614 17544 49698164
Joint swelling 3782.91 13.41 11150 878266 234136 49481572
Therapeutic product effect decreased 3743.56 13.41 7727 881689 128323 49587385
Therapeutic product effect incomplete 3515.67 13.41 5998 883418 85517 49630191
Injection site discolouration 3404.67 13.41 1890 887526 5084 49710624
Injection site induration 3201.79 13.41 1938 887478 6459 49709249
Pain in extremity 3089.59 13.41 11166 878250 261699 49454009
Acute kidney injury 2757.01 13.41 373 889043 227685 49488023
Product storage error 2696.50 13.41 2008 887408 10216 49705492
Toxicity to various agents 2674.88 13.41 304 889112 212195 49503513
Death 2631.60 13.41 1216 888200 324163 49391545
Pain 2627.13 13.41 18254 871162 560649 49155059
Hypotension 2591.36 13.41 499 888917 234970 49480738
Drug interaction 2572.62 13.41 262 889154 199359 49516349
Accidental exposure to product 2502.30 13.41 2525 886891 20532 49695176
Nasopharyngitis 2466.38 13.41 8224 881192 184703 49531005
Sinusitis 2397.30 13.41 7511 881905 163047 49552661
Device issue 2296.23 13.41 2257 887159 17715 49697993
Completed suicide 2240.64 13.41 13 889403 131876 49583832
Anaemia 2140.52 13.41 880 888536 251576 49464132
Injection site mass 2099.74 13.41 1928 887488 13752 49701956
Treatment failure 1983.55 13.41 6116 883300 131521 49584187
Musculoskeletal stiffness 1946.90 13.41 5811 883605 122670 49593038
Product dose omission issue 1830.91 13.41 7227 882189 176611 49539097
Mobility decreased 1790.79 13.41 4184 885232 75764 49639944
Dyspnoea 1743.77 13.41 4467 884949 543141 49172567
Febrile neutropenia 1550.81 13.41 34 889382 97633 49618075
Constipation 1541.61 13.41 667 888749 185041 49530667
Diarrhoea 1519.16 13.41 5292 884124 583184 49132524
Swelling 1482.83 13.41 7219 882197 193653 49522055
Hyponatraemia 1434.27 13.41 59 889357 96080 49619628
Therapeutic response decreased 1421.98 13.41 2788 886628 44443 49671265
Neutropenia 1379.67 13.41 441 888975 147524 49568184
Thrombocytopenia 1308.63 13.41 317 889099 127356 49588352
Injection site discomfort 1307.99 13.41 821 888595 2969 49712739
Drug intolerance 1306.67 13.41 7423 881993 211681 49504027
Abdominal pain 1305.47 13.41 1336 888080 234892 49480816
Dehydration 1304.55 13.41 523 888893 151926 49563782
Injection site haematoma 1304.10 13.41 981 888435 5079 49710629
Contraindicated product administered 1290.92 13.41 5613 883803 143345 49572363
Joint stiffness 1215.80 13.41 2027 887389 28281 49687427
Vomiting 1208.32 13.41 4112 885304 456646 49259062
Musculoskeletal pain 1179.97 13.41 3356 886060 68821 49646887
Malignant neoplasm progression 1150.05 13.41 8 889408 68116 49647592
Cardiac arrest 1138.32 13.41 87 889329 83564 49632144
Seizure 1085.10 13.41 359 889057 117515 49598193
Underdose 1051.97 13.41 1527 887889 18751 49696957
Hypokalaemia 1042.99 13.41 152 889264 87840 49627868
Haemoglobin decreased 1040.88 13.41 466 888950 126750 49588958
Tachycardia 1035.42 13.41 241 889175 99522 49616186
Disease progression 1022.31 13.41 218 889198 95648 49620060
Intentional overdose 999.08 13.41 20 889396 62484 49653224
Bradycardia 972.86 13.41 36 889380 64390 49651318
Arthropathy 966.31 13.41 5389 884027 152517 49563191
Drug abuse 953.18 13.41 20 889396 59826 49655882
Somnolence 917.96 13.41 823 888593 154162 49561546
Arthritis 910.26 13.41 3469 885947 83252 49632456
Overdose 903.44 13.41 312 889104 99415 49616293
Peripheral swelling 894.71 13.41 6440 882976 199496 49516212
Pancytopenia 894.09 13.41 192 889224 83838 49631870
Synovitis 882.95 13.41 4410 885006 119455 49596253
Respiratory failure 879.87 13.41 255 889161 90926 49624782
Pulmonary embolism 867.95 13.41 350 889066 101354 49614354
Oxygen saturation decreased 866.98 13.41 127 889289 73121 49642587
Electrocardiogram QT prolonged 866.50 13.41 8 889408 51878 49663830
Renal failure 851.42 13.41 404 889012 106229 49609479
Gastrointestinal haemorrhage 825.44 13.41 146 889270 73175 49642533
Respiratory tract congestion 816.06 13.41 1123 888293 13076 49702632
Nausea 810.15 13.41 8219 881197 697179 49018529
Injection site extravasation 798.09 13.41 813 888603 6688 49709020
Decreased appetite 796.70 13.41 1446 887970 199477 49516231
Platelet count decreased 789.90 13.41 391 889025 100335 49615373
Syncope 774.87 13.41 422 888994 102580 49613128
Injection site recall reaction 773.36 13.41 286 889130 125 49715583
Injection site macule 769.31 13.41 303 889113 213 49715495
Cardio-respiratory arrest 765.54 13.41 45 889371 53847 49661861
Hyperkalaemia 758.29 13.41 18 889398 48071 49667637
Musculoskeletal disorder 743.93 13.41 1196 888220 16153 49699555
Exposure during pregnancy 738.99 13.41 624 888792 120391 49595317
Depressed level of consciousness 736.09 13.41 44 889372 51909 49663799
Knee arthroplasty 732.02 13.41 1811 887605 34035 49681673
Suicide attempt 717.52 13.41 49 889367 51683 49664025
Hypoglycaemia 714.21 13.41 61 889355 53520 49662188
Deep vein thrombosis 712.75 13.41 202 889214 73102 49642606
Multiple sclerosis relapse 706.57 13.41 9 889407 42955 49672753
Finger deformity 699.66 13.41 667 888749 5015 49710693
Asthenia 698.30 13.41 3059 886357 315983 49399725
Hypoxia 693.08 13.41 54 889362 51069 49664639
Atrial fibrillation 689.84 13.41 471 888945 101274 49614434
Condition aggravated 684.35 13.41 8103 881313 288955 49426753
Coma 681.56 13.41 95 889321 56784 49658924
Confusional state 677.98 13.41 1406 888010 184522 49531186
Agitation 671.67 13.41 76 889340 53308 49662400
Sepsis 659.00 13.41 820 888596 132105 49583603
Infection 655.89 13.41 5240 884176 167714 49547994
International normalised ratio increased 648.42 13.41 25 889391 43127 49672581
Therapy non-responder 634.73 13.41 2158 887258 48864 49666844
Injection site irritation 631.69 13.41 560 888856 3790 49711918
Surgery 631.57 13.41 1540 887876 28665 49687043
Product use in unapproved indication 620.98 13.41 671 888745 115148 49600560
Cardiac failure 616.32 13.41 282 889134 75758 49639950
Tremor 595.97 13.41 684 888732 114219 49601489
Weight decreased 595.44 13.41 1949 887467 219296 49496412
Pleural effusion 594.91 13.41 346 889070 81108 49634600
Rhabdomyolysis 591.96 13.41 21 889395 39006 49676702
Fear of injection 589.25 13.41 628 888788 5475 49710233
Cardiac failure congestive 580.88 13.41 384 889032 83998 49631710
Injury associated with device 580.08 13.41 463 888953 2654 49713054
Nodule 579.99 13.41 1059 888357 15944 49699764
Skin plaque 572.20 13.41 629 888787 5699 49710009
Blood pressure decreased 572.18 13.41 139 889277 55770 49659938
Neutrophil count decreased 567.94 13.41 70 889346 45956 49669752
Psoriasis 564.18 13.41 2557 886859 66443 49649265
Dizziness 560.63 13.41 3676 885740 342693 49373015
Lactic acidosis 557.60 13.41 5 889411 33350 49682358
Metabolic acidosis 555.77 13.41 31 889385 38794 49676914
Oropharyngeal pain 537.77 13.41 2747 886669 75054 49640654
Pulmonary oedema 532.51 13.41 106 889310 48832 49666876
Hallucination 529.26 13.41 91 889325 46566 49669142
Injection site vesicles 528.10 13.41 407 889009 2198 49713510
Fall 526.74 13.41 3585 885831 331347 49384361
White blood cell count decreased 524.91 13.41 773 888643 115949 49599759
Incorrect dose administered by device 523.91 13.41 457 888959 3018 49712690
Blood pressure increased 522.99 13.41 963 888453 132169 49583539
Anxiety 504.85 13.41 1526 887890 176080 49539628
Blood creatinine increased 502.40 13.41 363 889053 75797 49639911
C-reactive protein abnormal 497.60 13.41 1337 888079 26472 49689236
Multiple organ dysfunction syndrome 494.35 13.41 136 889280 50201 49665507
Device expulsion 488.32 13.41 3 889413 28819 49686889
Injection site inflammation 482.21 13.41 421 888995 2784 49712924
Mental status changes 481.47 13.41 42 889374 36230 49679478
Sedation 476.75 13.41 13 889403 30597 49685111
Suicidal ideation 470.09 13.41 192 889224 55193 49660515
Heart rate increased 469.39 13.41 400 889016 76850 49638858
Bronchitis 465.80 13.41 3282 886134 100877 49614831
Drug hypersensitivity 465.30 13.41 6581 882835 244429 49471279
Neoplasm progression 463.23 13.41 10 889406 29147 49686561
Chest pain 462.80 13.41 1577 887839 175305 49540403
Hyperglycaemia 455.02 13.41 53 889363 36352 49679356
Influenza 454.18 13.41 2911 886505 86627 49629081
Ascites 453.76 13.41 50 889366 35811 49679897
Neuropathy peripheral 453.63 13.41 622 888794 96135 49619573
Drug dose omission by device 447.82 13.41 375 889041 2324 49713384
Red blood cell sedimentation rate abnormal 444.24 13.41 925 888491 15418 49700290
Alanine aminotransferase increased 439.95 13.41 543 888873 87816 49627892
Respiratory arrest 435.68 13.41 22 889394 29987 49685721
Blood bilirubin increased 431.01 13.41 35 889381 32003 49683705
Flushing 430.92 13.41 328 889088 66687 49649021
Unresponsive to stimuli 430.34 13.41 27 889389 30582 49685126
Mucosal inflammation 428.36 13.41 91 889325 40051 49675657
Encephalopathy 426.55 13.41 47 889369 33664 49682044
Foot deformity 424.77 13.41 1001 888415 18209 49697499
Cerebrovascular accident 421.77 13.41 631 888785 94049 49621659
Blood alkaline phosphatase increased 421.68 13.41 75 889341 37451 49678257
Grip strength decreased 417.28 13.41 758 888658 11363 49704345
Dyspnoea exertional 416.68 13.41 189 889227 51044 49664664
Foetal exposure during pregnancy 413.96 13.41 15 889401 27344 49688364
Paranasal sinus hypersecretion 410.16 13.41 381 889035 2761 49712947
Inflammation 409.77 13.41 2033 887383 54879 49660829
Drug reaction with eosinophilia and systemic symptoms 405.90 13.41 23 889393 28401 49687307
Orthostatic hypotension 405.68 13.41 29 889387 29452 49686256
Dysarthria 402.80 13.41 83 889333 37320 49678388
Ear infection 402.28 13.41 1185 888231 24785 49690923
Hypersensitivity 394.87 13.41 5632 883784 209529 49506179
Oedema 392.51 13.41 392 889024 69789 49645919
Serotonin syndrome 390.56 13.41 9 889407 24704 49691004
Pneumonia aspiration 390.33 13.41 44 889372 30960 49684748
Alopecia 384.46 13.41 6245 883171 238802 49476906
Osteonecrosis of jaw 381.10 13.41 58 889358 32468 49683240
Aspartate aminotransferase increased 379.26 13.41 488 888928 77510 49638198
Hypertension 377.32 13.41 2172 887244 209031 49506677
Transplant dysfunction 376.54 13.41 438 888978 4246 49711462
Drug withdrawal syndrome 368.57 13.41 17 889399 25064 49690644
Adverse reaction 368.20 13.41 592 888824 7994 49707714
Pharyngitis streptococcal 363.71 13.41 597 888819 8211 49707497
Respiratory distress 362.70 13.41 52 889364 30437 49685271
Psoriatic arthropathy 357.89 13.41 1707 887709 45325 49670383
Loss of consciousness 357.79 13.41 816 888600 103537 49612171
General physical health deterioration 357.61 13.41 1292 888124 141142 49574566
Hepatic function abnormal 357.20 13.41 70 889346 32611 49683097
Plasma cell myeloma 355.44 13.41 61 889355 31261 49684447
Disorientation 353.83 13.41 93 889323 35391 49680317
Melaena 351.45 13.41 33 889383 26831 49688877
Dysphagia 349.74 13.41 512 888904 77006 49638702
Hypomagnesaemia 349.30 13.41 13 889403 23143 49692565
Blood glucose increased 349.10 13.41 444 888972 70880 49644828
Renal impairment 348.99 13.41 492 888924 75169 49640539
Intentional self-injury 348.55 13.41 13 889403 23099 49692609
Hypervolaemia 348.24 13.41 26 889390 25473 49690235
Hand deformity 347.29 13.41 2976 886440 97223 49618485
Gamma-glutamyltransferase increased 342.14 13.41 55 889361 29568 49686140
Chronic kidney disease 338.91 13.41 137 889279 39634 49676074
Cognitive disorder 338.68 13.41 176 889240 43947 49671761
Lymphocyte count decreased 337.13 13.41 35 889381 26272 49689436
Acute myocardial infarction 336.64 13.41 55 889361 29218 49686490
Acute respiratory failure 335.68 13.41 52 889364 28730 49686978
Coronary artery disease 334.90 13.41 59 889357 29667 49686041
Unevaluable event 331.90 13.41 1646 887770 44420 49671288
Fluid retention 330.62 13.41 244 889172 50405 49665303
Loss of personal independence in daily activities 330.61 13.41 2237 887179 67813 49647895
Pulmonary hypertension 330.53 13.41 89 889327 33328 49682380
Hepatic failure 326.91 13.41 82 889334 32201 49683507
Blood pressure systolic increased 325.92 13.41 108 889308 35341 49680367
Palpitations 324.79 13.41 738 888678 93768 49621940
Herpes zoster 324.28 13.41 2244 887172 68542 49647166
Bone marrow failure 324.24 13.41 49 889367 27575 49688133
Hepatocellular injury 323.70 13.41 38 889378 25909 49689799
Red blood cell sedimentation rate increased 321.82 13.41 1193 888223 28223 49687485
Injection site hypersensitivity 319.33 13.41 260 889156 1540 49714168
Heart rate decreased 317.12 13.41 122 889294 36375 49679333
Haematemesis 316.81 13.41 53 889363 27672 49688036
Blood creatine phosphokinase increased 315.92 13.41 44 889372 26323 49689385
Delirium 313.53 13.41 139 889277 38053 49677655
Gastrooesophageal reflux disease 313.36 13.41 538 888878 75890 49639818
Pneumonia 308.40 13.41 4737 884679 373664 49342044
Haematochezia 306.23 13.41 159 889257 39723 49675985
Jaundice 305.39 13.41 49 889367 26380 49689328
Cholestasis 305.26 13.41 42 889374 25359 49690349
Drug level increased 300.74 13.41 8 889408 19260 49696448
Product quality issue 299.94 13.41 85 889331 30773 49684935
Depression 297.57 13.41 1697 887719 163726 49551982
Pulmonary arterial hypertension 294.63 13.41 15 889401 20304 49695404
Rectal haemorrhage 292.70 13.41 156 889260 38402 49677306
Generalised tonic-clonic seizure 292.54 13.41 54 889362 26256 49689452
Upper respiratory tract infection 290.68 13.41 2070 887346 63828 49651880
Rhinorrhoea 289.06 13.41 1721 887695 49862 49665846
Toxic epidermal necrolysis 287.83 13.41 21 889395 20971 49694737
Blood urea increased 285.80 13.41 38 889378 23547 49692161
Myalgia 280.42 13.41 1177 888239 123142 49592566
Myocardial infarction 277.78 13.41 731 888685 88296 49627412
Psychotic disorder 277.00 13.41 30 889386 21782 49693926
Urinary retention 276.11 13.41 61 889355 26129 49689579
Systemic lupus erythematosus 275.12 13.41 3724 885692 136898 49578810
Chest discomfort 273.86 13.41 782 888634 91940 49623768
Contusion 273.84 13.41 3097 886319 109086 49606622
Joint destruction 273.57 13.41 341 889075 3575 49712133
Altered state of consciousness 273.55 13.41 32 889384 21878 49693830
Septic shock 271.48 13.41 364 889052 56811 49658897
Haemorrhage 268.50 13.41 326 889090 53115 49662593
Hypocalcaemia 267.91 13.41 70 889346 26746 49688962
Therapy interrupted 266.18 13.41 870 888546 19282 49696426
Pyrexia 265.55 13.41 4895 884521 375308 49340400
Balance disorder 265.31 13.41 524 888892 70066 49645642
Impaired healing 264.91 13.41 2116 887300 67670 49648038
Aggression 263.23 13.41 31 889385 21085 49694623
Lethargy 262.99 13.41 288 889128 49144 49666564
Arrhythmia 262.03 13.41 127 889289 33005 49682703
Oedema peripheral 261.19 13.41 1664 887752 156297 49559411
Device dislocation 260.40 13.41 35 889381 21511 49694197
Foot operation 260.00 13.41 397 889019 5113 49710595
Blood pressure fluctuation 257.48 13.41 155 889261 35668 49680040
Sinus tachycardia 257.34 13.41 35 889381 21319 49694389
Adverse drug reaction 256.67 13.41 1757 887659 53465 49662243
Sinus headache 255.70 13.41 358 889058 4240 49711468
Circulatory collapse 255.28 13.41 27 889389 19973 49695735
Angioedema 254.43 13.41 175 889241 37501 49678207
Stevens-Johnson syndrome 254.35 13.41 39 889377 21713 49693995
Agranulocytosis 253.71 13.41 37 889379 21384 49694324
Shock 253.29 13.41 32 889384 20618 49695090
Ejection fraction decreased 252.58 13.41 19 889397 18501 49697207
Gait disturbance 252.32 13.41 3869 885547 146136 49569572
Withdrawal syndrome 251.88 13.41 14 889402 17576 49698132
Joint range of motion decreased 251.56 13.41 807 888609 17705 49698003
Aphasia 249.64 13.41 94 889322 28400 49687308
Haematocrit decreased 249.06 13.41 153 889263 34823 49680885
Pancreatitis acute 247.95 13.41 57 889359 23755 49691953
Leukocytosis 247.52 13.41 48 889368 22531 49693177
Haematoma 247.37 13.41 113 889303 30397 49685311
Hip arthroplasty 246.59 13.41 1125 888291 29304 49686404
Therapeutic product effect delayed 246.46 13.41 236 889180 1785 49713923
Blood potassium decreased 246.32 13.41 174 889242 36771 49678937
Sinus congestion 246.18 13.41 668 888748 13303 49702405
Blood calcium decreased 244.70 13.41 36 889380 20670 49695038
Full blood count decreased 243.92 13.41 48 889368 22298 49693410
Leukopenia 242.97 13.41 514 888902 67014 49648694
Diabetic ketoacidosis 239.08 13.41 20 889396 17852 49697856
Small intestinal obstruction 239.04 13.41 10 889406 16058 49699650
Injection site nodule 237.83 13.41 294 889122 3054 49712654
Cerebral haemorrhage 237.41 13.41 89 889327 26963 49688745
Accidental overdose 235.43 13.41 32 889384 19501 49696207
Ventricular tachycardia 234.85 13.41 10 889406 15811 49699897
Neurotoxicity 234.36 13.41 5 889411 14735 49700973
Posterior reversible encephalopathy syndrome 233.74 13.41 6 889410 14922 49700786
Rubber sensitivity 233.51 13.41 218 889198 1591 49714117
Myoclonus 229.71 13.41 5 889411 14465 49701243
Acute hepatic failure 229.14 13.41 11 889405 15666 49700042
Electrolyte imbalance 227.52 13.41 20 889396 17149 49698559
Epistaxis 227.42 13.41 490 888926 63464 49652244
Increased tendency to bruise 227.25 13.41 506 888910 8850 49706858
Rash maculo-papular 226.61 13.41 92 889324 26549 49689159
Neck pain 226.30 13.41 1748 887668 55319 49660389
Thrombosis 226.14 13.41 396 889020 55437 49660271
Upper gastrointestinal haemorrhage 225.83 13.41 14 889402 16021 49699687
Cerebral infarction 222.40 13.41 53 889363 21551 49694157
Blood lactate dehydrogenase increased 222.17 13.41 38 889378 19524 49696184
Blood pressure diastolic decreased 221.16 13.41 20 889396 16761 49698947
Right ventricular failure 220.50 13.41 15 889401 15878 49699830
Bone erosion 220.32 13.41 573 888843 11114 49704594
Abdominal distension 218.84 13.41 610 888806 72293 49643415
Abnormal behaviour 217.17 13.41 41 889375 19617 49696091
Emotional distress 216.04 13.41 117 889299 28546 49687162
No adverse event 213.70 13.41 166 889250 33412 49682296
Eosinophilia 212.35 13.41 36 889380 18616 49697092
Epilepsy 212.23 13.41 58 889358 21509 49694199
Status epilepticus 211.39 13.41 5 889411 13401 49702307
Urinary incontinence 211.36 13.41 116 889300 28092 49687616
Dyskinesia 211.06 13.41 113 889303 27748 49687960
Neutropenic sepsis 209.81 13.41 9 889407 14138 49701570
Hallucination, visual 207.56 13.41 24 889392 16558 49699150
Gastritis 207.46 13.41 165 889251 32818 49682890
Cardiogenic shock 207.18 13.41 18 889398 15581 49700127
Inappropriate antidiuretic hormone secretion 206.86 13.41 5 889411 13138 49702570
Pancreatitis 206.70 13.41 267 889149 42347 49673361
Knee operation 206.23 13.41 334 889082 4539 49711169
Adverse event 206.09 13.41 1397 888019 42366 49673342
Chondrolysis 201.98 13.41 90 889326 118 49715590
Tachypnoea 201.54 13.41 14 889402 14563 49701145
Therapy cessation 201.42 13.41 949 888467 25062 49690646
Shoulder arthroplasty 200.04 13.41 274 889142 3174 49712534
Cholelithiasis 198.96 13.41 224 889192 37749 49677959
Restlessness 198.29 13.41 97 889319 25076 49690632
Haematuria 198.29 13.41 101 889315 25512 49690196
Clostridium difficile colitis 198.15 13.41 36 889380 17706 49698002
Intentional product misuse 197.97 13.41 1454 887962 45280 49670428
Rheumatoid factor positive 197.56 13.41 1527 887889 48332 49667376
Hemiparesis 197.12 13.41 54 889362 19994 49695714
Respiratory depression 195.35 13.41 3 889413 12007 49703701
Pemphigus 193.84 13.41 3078 886338 117088 49598620
Rheumatoid nodule 193.30 13.41 577 888839 12158 49703550
Coagulopathy 192.82 13.41 40 889376 17904 49697804
Colitis 192.52 13.41 236 889180 38293 49677415
Infusion site pain 189.49 13.41 6 889410 12340 49703368
Pericardial effusion 189.17 13.41 107 889309 25482 49690226
Tuberculin test positive 189.11 13.41 256 889160 2930 49712778
Injection site injury 188.77 13.41 120 889296 446 49715262
Poisoning 187.39 13.41 7 889409 12422 49703286
Arthropod bite 186.83 13.41 361 889055 5684 49710024
Asthma 184.98 13.41 873 888543 88464 49627244
Sinus bradycardia 184.20 13.41 12 889404 13171 49702537
Metastases to bone 183.57 13.41 45 889371 17950 49697758
Cyanosis 182.70 13.41 25 889391 15159 49700549
Osteonecrosis 181.61 13.41 84 889332 22433 49693275
Hypothermia 180.36 13.41 7 889409 12009 49703699
Neuroleptic malignant syndrome 180.11 13.41 3 889413 11127 49704581
Face oedema 179.29 13.41 46 889370 17793 49697915
Myelosuppression 178.43 13.41 16 889400 13501 49702207
Rash 178.33 13.41 9395 880021 428076 49287632
Ischaemic stroke 176.73 13.41 33 889383 15915 49699793
Obstructive airways disorder 176.45 13.41 31 889385 15621 49700087
Acute respiratory distress syndrome 174.42 13.41 76 889340 21023 49694685
Abdominal discomfort 174.02 13.41 5315 884101 226326 49489382
Wheezing 173.98 13.41 536 888880 61511 49654197
Presyncope 170.70 13.41 107 889309 24091 49691617
Anuria 170.67 13.41 6 889410 11238 49704470
Blood sodium decreased 170.38 13.41 79 889337 21068 49694640
Medication error 170.22 13.41 231 889185 35873 49679835
Extrapyramidal disorder 169.67 13.41 9 889407 11761 49703947
Acne 168.95 13.41 738 888678 18857 49696851
Angina pectoris 168.52 13.41 128 889288 26060 49689648
Sneezing 168.43 13.41 587 888829 13457 49702251
Haemorrhage intracranial 167.88 13.41 13 889403 12361 49703347
Premature delivery 167.80 13.41 104 889312 23559 49692149
Antibiotic therapy 167.77 13.41 138 889278 831 49714877
Disturbance in attention 166.64 13.41 181 889235 31005 49684703
Transient ischaemic attack 166.58 13.41 192 889224 32018 49683690
Corrective lens user 166.55 13.41 78 889338 124 49715584
Subdural haematoma 166.48 13.41 17 889399 12930 49702778
Mycobacterium tuberculosis complex test positive 165.69 13.41 179 889237 1587 49714121
Gastroenteritis 164.15 13.41 103 889313 23178 49692530
Dystonia 163.31 13.41 12 889404 11914 49703794
Premature baby 163.15 13.41 59 889357 18278 49697430
Sleep disorder due to general medical condition, insomnia type 162.76 13.41 1028 888388 30419 49685289
Decreased immune responsiveness 162.55 13.41 267 889149 3674 49712034
Intestinal obstruction 162.17 13.41 135 889281 26248 49689460
Labelled drug-drug interaction medication error 161.13 13.41 5 889411 10472 49705236
Speech disorder 159.10 13.41 236 889180 35312 49680396
Ill-defined disorder 158.69 13.41 1563 887853 53091 49662617
Acidosis 156.85 13.41 5 889411 10222 49705486
Cytomegalovirus infection 156.10 13.41 60 889356 17902 49697806
Ataxia 156.08 13.41 27 889389 13759 49701949
Red blood cell count decreased 155.99 13.41 220 889196 33615 49682093
Lymphopenia 155.62 13.41 41 889375 15580 49700128
Headache 155.28 13.41 10607 878809 495928 49219780
Joint arthroplasty 154.96 13.41 189 889227 1934 49713774
Brain oedema 154.59 13.41 18 889398 12352 49703356
Extra dose administered 154.28 13.41 301 889115 4775 49710933
Hepatic enzyme increased 154.20 13.41 3326 886090 134054 49581654
Cough 154.20 13.41 5431 883985 235833 49479875
Spinal operation 153.66 13.41 340 889076 5920 49709788
Transfusion 153.51 13.41 22 889394 12883 49702825
Bacteraemia 153.39 13.41 33 889383 14400 49701308
Drug ineffective for unapproved indication 153.04 13.41 92 889324 21189 49694519
Product prescribing error 153.02 13.41 89 889327 20872 49694836
Complication associated with device 152.74 13.41 35 889381 14620 49701088
Treatment noncompliance 152.41 13.41 183 889233 29967 49685741
Renal tubular necrosis 152.36 13.41 6 889410 10162 49705546
Anhedonia 152.34 13.41 3 889413 9521 49706187
Demyelination 150.98 13.41 330 889086 5696 49710012
Chronic obstructive pulmonary disease 150.96 13.41 460 888956 52975 49662733
Haemoptysis 150.94 13.41 136 889280 25437 49690271
Metastases to liver 150.15 13.41 83 889333 20021 49695687
Drug dependence 149.87 13.41 80 889336 19679 49696029
Cardiomegaly 149.36 13.41 47 889369 15898 49699810
Ear pain 147.88 13.41 927 888489 27356 49688352
Disability 147.22 13.41 527 888889 12248 49703460
Mania 146.61 13.41 12 889404 10904 49704804
Blood pressure diastolic abnormal 145.67 13.41 4 889412 9357 49706351
Nasal congestion 145.54 13.41 1456 887960 49664 49666044
Tricuspid valve incompetence 144.60 13.41 25 889391 12745 49702963
Fibromyalgia 144.37 13.41 1314 888102 43664 49672044
Respiratory rate increased 143.70 13.41 16 889400 11369 49704339
Drug-induced liver injury 143.64 13.41 169 889247 27926 49687782
Flatulence 143.45 13.41 184 889232 29274 49686434
Localised infection 143.19 13.41 851 888565 24634 49691074
Tooth infection 142.52 13.41 558 888858 13554 49702154
Malaise 141.61 13.41 7231 882185 328301 49387407
Osteoarthritis 141.13 13.41 1834 887582 66772 49648936
Breast cancer 140.22 13.41 1258 888158 41632 49674076
Left ventricular dysfunction 139.86 13.41 12 889404 10494 49705214
Mitral valve incompetence 139.63 13.41 66 889350 17405 49698303
Supraventricular tachycardia 138.66 13.41 28 889388 12773 49702935
Infusion site erythema 138.59 13.41 3 889413 8724 49706984
Transaminases increased 137.36 13.41 172 889244 27652 49688056
Full blood count abnormal 137.30 13.41 125 889291 23263 49692445
Parkinsonism 136.86 13.41 4 889412 8843 49706865
Joint warmth 136.85 13.41 144 889272 1235 49714473
Disseminated intravascular coagulation 136.53 13.41 65 889351 17070 49698638
Dyspepsia 135.32 13.41 756 888660 73341 49642367
Tubulointerstitial nephritis 135.23 13.41 49 889367 15162 49700546
Cholecystitis chronic 134.51 13.41 9 889407 9660 49706048
Injection site papule 134.39 13.41 108 889308 626 49715082
Myelodysplastic syndrome 134.10 13.41 49 889367 15083 49700625
Walking aid user 133.37 13.41 327 889089 6106 49709602
Malnutrition 132.56 13.41 34 889382 13155 49702553
Metastases to central nervous system 132.43 13.41 20 889396 11262 49704446
Joint effusion 132.42 13.41 516 888900 12505 49703203
Vision blurred 132.18 13.41 824 888592 77823 49637885
Injury 131.99 13.41 430 888986 48495 49667213
Shock haemorrhagic 131.99 13.41 3 889413 8341 49707367
Mydriasis 131.48 13.41 16 889400 10611 49705097
Blood iron abnormal 131.38 13.41 221 889195 3105 49712603
Ileus 131.26 13.41 35 889381 13194 49702514
Limb operation 130.85 13.41 222 889194 3142 49712566
Ventricular fibrillation 130.38 13.41 16 889400 10543 49705165
Skin haemorrhage 130.21 13.41 339 889077 6579 49709129
Dysgeusia 128.73 13.41 310 889106 38606 49677102
Abdominal pain lower 128.05 13.41 116 889300 21640 49694068
Diabetes mellitus inadequate control 126.28 13.41 37 889379 13108 49702600
Oliguria 126.07 13.41 4 889412 8212 49707496
Sleep apnoea syndrome 125.90 13.41 140 889276 23728 49691980
Acute generalised exanthematous pustulosis 125.28 13.41 8 889408 8930 49706778
Glossodynia 125.21 13.41 2784 886632 112785 49602923
Intentional product use issue 125.11 13.41 814 888602 76104 49639604
Weight increased 124.92 13.41 2651 886765 199240 49516468
Rash pruritic 124.47 13.41 1338 888078 46508 49669200
Blood magnesium decreased 123.86 13.41 23 889393 11137 49704571
Acute myeloid leukaemia 123.49 13.41 55 889361 15019 49700689
Hypothyroidism 122.51 13.41 260 889156 33865 49681843
Taste disorder 121.15 13.41 6 889410 8318 49707390
Urine output decreased 121.12 13.41 19 889397 10402 49705306
Troponin increased 120.93 13.41 5 889411 8113 49707595
Stress 120.89 13.41 1462 887954 52331 49663377
Hyperhidrosis 120.64 13.41 998 888418 88428 49627280
Myocardial ischaemia 120.50 13.41 28 889388 11585 49704123
Cardiac disorder 119.97 13.41 372 889044 42607 49673101
Joint lock 119.65 13.41 164 889252 1901 49713807
Joint noise 119.27 13.41 221 889195 3366 49712342
Device related infection 119.15 13.41 113 889303 20622 49695086
Heart rate irregular 119.07 13.41 99 889317 19261 49696447
Muscle rigidity 118.70 13.41 16 889400 9813 49705895
Anal incontinence 118.64 13.41 28 889388 11462 49704246
Nightmare 117.85 13.41 68 889348 16018 49699690
Irritability 117.47 13.41 199 889217 28227 49687481
Device malfunction 117.29 13.41 552 888864 14569 49701139
Sinus disorder 117.29 13.41 637 888779 17821 49697887
Thrombotic microangiopathy 117.14 13.41 10 889406 8781 49706927
Joint fluid drainage 116.95 13.41 60 889356 129 49715579
Delusion 116.84 13.41 22 889394 10547 49705161
Acute coronary syndrome 116.25 13.41 14 889402 9360 49706348
Haemodynamic instability 116.09 13.41 6 889410 8018 49707690
Prothrombin time prolonged 115.22 13.41 11 889405 8827 49706881
Hallucination, auditory 115.10 13.41 24 889392 10704 49705004
Renal injury 114.19 13.41 10 889406 8601 49707107
Transplant rejection 113.82 13.41 400 889016 9209 49706499
Blood albumin decreased 113.73 13.41 45 889371 13191 49702517
Tardive dyskinesia 113.68 13.41 3 889413 7276 49708432
Body temperature decreased 113.58 13.41 74 889342 16321 49699387
Paranoia 113.42 13.41 22 889394 10326 49705382
Toxic skin eruption 113.09 13.41 29 889387 11222 49704486
Atelectasis 112.89 13.41 93 889323 18177 49697531
Vertigo 112.32 13.41 498 888918 51334 49664374
Hypoalbuminaemia 112.31 13.41 19 889397 9841 49705867
Blood loss anaemia 111.99 13.41 8 889408 8131 49707577
Infusion site swelling 111.92 13.41 3 889413 7173 49708535
Haemodialysis 110.10 13.41 10 889406 8352 49707356
Aspiration 109.71 13.41 16 889400 9248 49706460
Joint injury 109.49 13.41 707 888709 21082 49694626
Urinary tract infection 109.43 13.41 3048 886368 220972 49494736
White blood cell count increased 108.65 13.41 379 889037 41861 49673847
Haematotoxicity 107.94 13.41 8 889408 7887 49707821
Device failure 107.26 13.41 274 889142 5254 49710454
Clostridium difficile infection 107.06 13.41 176 889240 25263 49690445
Lower gastrointestinal haemorrhage 106.82 13.41 3 889413 6876 49708832
Pustular psoriasis 106.63 13.41 224 889192 3757 49711951
Wrist surgery 106.55 13.41 98 889318 700 49715008
Frequent bowel movements 106.07 13.41 56 889360 13862 49701846
Myopathy 105.46 13.41 17 889399 9122 49706586
Injection site paraesthesia 105.42 13.41 79 889337 406 49715302
Product complaint 105.27 13.41 35 889381 11431 49704277
Infusion site extravasation 104.93 13.41 4 889412 6972 49708736
Hypophagia 104.86 13.41 205 889211 27523 49688185
Oesophagitis 104.75 13.41 52 889364 13331 49702377
Glomerular filtration rate decreased 104.50 13.41 37 889379 11615 49704093
Impaired work ability 104.39 13.41 496 888920 13144 49702564
Eye disorder 104.15 13.41 624 888792 18115 49697593
Iritis 103.90 13.41 171 889245 2357 49713351
Secretion discharge 103.66 13.41 393 889023 9398 49706310
Haemolytic anaemia 103.45 13.41 19 889397 9273 49706435
Cardiomyopathy 103.10 13.41 74 889342 15512 49700196
Lipase increased 102.91 13.41 14 889402 8527 49707181
Anaphylactic shock 102.22 13.41 122 889294 20033 49695675
Hypovolaemia 101.90 13.41 21 889395 9444 49706264
Mental disorder 101.35 13.41 143 889273 21848 49693860
Haemorrhoids 101.33 13.41 111 889305 18942 49696766
Cardiac failure acute 100.66 13.41 13 889403 8237 49707471
Fine motor skill dysfunction 99.75 13.41 222 889194 3881 49711827
Rales 99.75 13.41 26 889390 9952 49705756
Nephropathy toxic 99.55 13.41 12 889404 8017 49707691
Vaginal haemorrhage 99.51 13.41 174 889242 24377 49691331
Injection site laceration 99.36 13.41 45 889371 63 49715645
Pharyngitis 99.31 13.41 586 888830 16917 49698791
Ovarian cyst 99.27 13.41 498 888918 13498 49702210
Uterine perforation 98.88 13.41 3 889413 6412 49709296
Ventricular extrasystoles 98.49 13.41 31 889385 10485 49705223
Peritonitis 97.97 13.41 77 889339 15409 49700299
Faecaloma 97.76 13.41 7 889409 7101 49708607
Hypernatraemia 97.27 13.41 3 889413 6318 49709390
Muscle spasms 97.08 13.41 1586 887830 123967 49591741
Miosis 97.08 13.41 3 889413 6307 49709401
Furuncle 96.99 13.41 265 889151 5299 49710409
Spinal fusion surgery 96.95 13.41 216 889200 3779 49711929
Hyperthermia 96.67 13.41 11 889405 7685 49708023
Product substitution issue 96.63 13.41 64 889352 13993 49701715
Neutrophil count increased 95.74 13.41 66 889350 14129 49701579
Cytopenia 95.45 13.41 19 889397 8756 49706952
Infusion related reaction 95.29 13.41 2260 887156 167297 49548411
Therapeutic response delayed 95.26 13.41 79 889337 482 49715226
Atrioventricular block first degree 95.22 13.41 3 889413 6198 49709510
Atrioventricular block complete 94.66 13.41 9 889407 7246 49708462
Second primary malignancy 94.55 13.41 7 889409 6907 49708801
Apathy 94.28 13.41 11 889405 7537 49708171
Lower respiratory tract infection 94.01 13.41 2264 887152 92937 49622771
Klebsiella infection 93.66 13.41 9 889407 7185 49708523
Pallor 93.50 13.41 165 889251 23034 49692674
Blood potassium increased 93.48 13.41 90 889326 16308 49699400
Circumstance or information capable of leading to medication error 93.21 13.41 186 889230 3002 49712706
Liver function test increased 93.09 13.41 769 888647 24837 49690871
Hospitalisation 93.07 13.41 755 888661 67182 49648526
Pneumonitis 92.99 13.41 241 889175 29269 49686439
Urosepsis 92.77 13.41 81 889335 15384 49700324
COVID-19 pneumonia 91.69 13.41 18 889398 8377 49707331
Chondropathy 91.69 13.41 146 889270 1954 49713754
Enterococcal infection 91.50 13.41 8 889408 6890 49708818
Failure to thrive 91.22 13.41 5 889411 6353 49709355
Scratch 91.19 13.41 241 889175 4721 49710987
Drug resistance 91.02 13.41 120 889296 18869 49696839
Insomnia 90.61 13.41 2359 887057 172506 49543202
Shoulder operation 89.46 13.41 138 889278 1794 49713914
Chromaturia 89.25 13.41 75 889341 14515 49701193
Respiratory acidosis 88.85 13.41 4 889412 6024 49709684
Incorrect disposal of product 88.66 13.41 77 889339 505 49715203
Limb discomfort 88.29 13.41 731 888685 23626 49692082
Drug level decreased 88.25 13.41 7 889409 6526 49709182
Hydronephrosis 87.82 13.41 21 889395 8520 49707188
Bronchospasm 87.66 13.41 79 889337 14775 49700933
Tumour lysis syndrome 87.46 13.41 13 889403 7408 49708300
Macule 87.43 13.41 122 889294 1440 49714268
Stress cardiomyopathy 85.95 13.41 17 889399 7870 49707838
Bronchitis chronic 85.66 13.41 202 889214 3675 49712033
Hyperlipidaemia 85.41 13.41 109 889307 17381 49698327
Rash erythematous 85.31 13.41 963 888453 33889 49681819
Blood pressure systolic abnormal 85.27 13.41 16 889400 7690 49708018
Viral upper respiratory tract infection 85.26 13.41 294 889122 6702 49709006
Colitis ischaemic 85.24 13.41 30 889386 9453 49706255
Sudden death 85.11 13.41 26 889390 8965 49706743
Polyneuropathy 85.07 13.41 54 889362 12077 49703631
Exostosis 85.04 13.41 418 888998 11235 49704473
Acute pulmonary oedema 85.03 13.41 13 889403 7254 49708454
Hypertensive crisis 85.01 13.41 64 889352 13090 49702618
Abortion induced 84.95 13.41 29 889387 9315 49706393
Schizophrenia 84.82 13.41 14 889402 7383 49708325
Hepatomegaly 84.38 13.41 42 889374 10751 49704957
Rash papular 84.19 13.41 441 888975 12163 49703545
Cholecystitis 83.99 13.41 72 889344 13799 49701909
Arthrodesis 83.75 13.41 154 889262 2331 49713377
Uveitis 83.60 13.41 355 889061 8955 49706753
Proteinuria 83.60 13.41 101 889315 16496 49699212
Angina unstable 83.20 13.41 10 889406 6696 49709012
Aplastic anaemia 83.12 13.41 17 889399 7686 49708022
Normal newborn 82.96 13.41 10 889406 6681 49709027
Dialysis 82.89 13.41 31 889385 9407 49706301
Myocarditis 82.78 13.41 19 889397 7928 49707780
Deformity 82.66 13.41 317 889099 7623 49708085
Psychomotor hyperactivity 82.62 13.41 30 889386 9271 49706437
Faeces discoloured 82.41 13.41 97 889319 16027 49699681
Folliculitis 82.08 13.41 1052 888364 38173 49677535
Limb deformity 81.91 13.41 194 889222 3540 49712168
Onychomycosis 80.88 13.41 233 889183 4809 49710899
Increased upper airway secretion 80.85 13.41 174 889242 2970 49712738
End stage renal disease 80.82 13.41 5 889411 5732 49709976
Activated partial thromboplastin time prolonged 80.79 13.41 9 889407 6393 49709315
Incorrect product administration duration 80.57 13.41 31 889385 9244 49706464
Apnoea 80.29 13.41 13 889403 6953 49708755
Muscle injury 80.07 13.41 1001 888415 36110 49679598
Toothache 79.93 13.41 540 888876 16354 49699354
Haemolysis 79.74 13.41 7 889409 6009 49709699
Poor venous access 79.70 13.41 41 889375 10299 49705409
Hepatitis acute 79.10 13.41 21 889395 7940 49707768
Hepatic necrosis 78.96 13.41 3 889413 5245 49710463
Muscular weakness 78.90 13.41 1184 888232 93829 49621879
Deafness transitory 78.60 13.41 125 889291 1671 49714037
Subarachnoid haemorrhage 78.31 13.41 46 889370 10730 49704978
Atrial flutter 78.29 13.41 28 889388 8735 49706973
Lung infiltration 78.12 13.41 72 889344 13321 49702387
Swollen tongue 77.65 13.41 251 889165 28379 49687329
Hepatic cytolysis 77.49 13.41 23 889393 8080 49707628
Metastases to lung 77.35 13.41 49 889367 10971 49704737
Metabolic encephalopathy 76.81 13.41 3 889413 5118 49710590
Immune system disorder 76.66 13.41 317 889099 7900 49707808
Hypotonia 76.14 13.41 24 889392 8110 49707598
COVID-19 75.76 13.41 494 888922 46168 49669540
Erythema multiforme 75.76 13.41 32 889384 9018 49706690
Blood lactic acid increased 75.40 13.41 6 889410 5579 49710129
Tinnitus 75.35 13.41 248 889168 27884 49687824
Anti-cyclic citrullinated peptide antibody positive 75.33 13.41 1697 887719 68890 49646818
Decubitus ulcer 74.61 13.41 36 889380 9382 49706326
Arteriosclerosis 74.54 13.41 33 889383 9044 49706664
Anaphylactic reaction 74.37 13.41 600 888816 53455 49662253
Hiatus hernia 74.35 13.41 130 889286 18214 49697494
Enteritis 74.32 13.41 16 889400 6979 49708729
Hip surgery 74.05 13.41 152 889264 2506 49713202
Cholecystitis acute 74.00 13.41 17 889399 7089 49708619
Device use error 73.76 13.41 232 889184 5034 49710674
Bone pain 73.68 13.41 506 888910 46723 49668985
Renal disorder 73.31 13.41 243 889173 27262 49688446
Ageusia 72.77 13.41 58 889358 11525 49704183
Lip swelling 72.70 13.41 209 889207 24527 49691181
Wound 72.60 13.41 2402 887014 103392 49612316
Low birth weight baby 72.40 13.41 9 889407 5872 49709836
Salivary hypersecretion 72.26 13.41 14 889402 6577 49709131
Polyuria 72.26 13.41 18 889398 7103 49708605
Pneumothorax 72.19 13.41 84 889332 13950 49701758
Incontinence 72.03 13.41 43 889373 9942 49705766
Genital haemorrhage 72 13.41 14 889402 6560 49709148
Foetal death 71.62 13.41 27 889389 8153 49707555
Head injury 71.29 13.41 202 889214 23818 49691890
Feeling abnormal 71.09 13.41 2788 886628 122704 49593004
Blood triglycerides increased 70.62 13.41 57 889359 11255 49704453
Atrial septal defect 70.52 13.41 13 889403 6328 49709380
Jaundice cholestatic 70.39 13.41 5 889411 5106 49710602
Concomitant disease aggravated 70.35 13.41 27 889389 8064 49707644
Laryngitis 70.21 13.41 379 889037 10577 49705131
Atypical femur fracture 70.12 13.41 4 889412 4912 49710796
Asphyxia 70.10 13.41 7 889409 5420 49710288
Eosinophil count increased 69.58 13.41 34 889382 8796 49706912
Spinal pain 69.43 13.41 374 889042 10429 49705279
Fistula 68.88 13.41 29 889387 8189 49707519
Chills 68.70 13.41 1240 888176 95447 49620261
Hemiplegia 68.70 13.41 22 889394 7359 49708349
Hospice care 68.28 13.41 10 889406 5762 49709946
Ankle deformity 67.99 13.41 58 889358 370 49715338
Skin ulcer 67.99 13.41 933 888483 34385 49681323
Injection site oedema 67.88 13.41 90 889326 1008 49714700
Amylase increased 67.61 13.41 8 889408 5422 49710286
Bradyphrenia 67.59 13.41 13 889403 6139 49709569
Arteriosclerosis coronary artery 67.20 13.41 25 889391 7611 49708097
Granulocytopenia 66.92 13.41 7 889409 5224 49710484
Intestinal ischaemia 66.80 13.41 18 889398 6739 49708969
Gait inability 66.40 13.41 966 888450 36061 49679647
Ecchymosis 66.33 13.41 49 889367 10120 49705588
Affect lability 65.97 13.41 38 889378 8960 49706748
Hyperthyroidism 65.78 13.41 70 889346 12105 49703603
Rheumatoid factor increased 65.75 13.41 101 889315 1308 49714400
Blood pressure systolic decreased 65.50 13.41 11 889405 5728 49709980
Dementia 65.17 13.41 113 889303 15884 49699824
Skin discolouration 64.97 13.41 870 888546 31887 49683821
Device breakage 64.91 13.41 44 889372 9503 49706205
Foetal growth restriction 64.87 13.41 18 889398 6609 49709099
Orthopnoea 64.71 13.41 11 889405 5678 49710030
Ankle operation 64.49 13.41 93 889323 1134 49714574
Forced expiratory volume decreased 64.49 13.41 3 889413 4391 49711317
Dysuria 64.11 13.41 270 889146 28234 49687474
Tuberculosis 64.08 13.41 348 889068 9735 49705973
Aspergillus infection 64.07 13.41 20 889396 6801 49708907
Enterocolitis 63.98 13.41 18 889398 6549 49709159
Abdominal pain upper 63.73 13.41 2225 887191 157084 49558624
Hypovolaemic shock 63.72 13.41 8 889408 5180 49710528
Musculoskeletal deformity 63.31 13.41 82 889334 896 49714812
Bronchopulmonary aspergillosis 63.30 13.41 27 889389 7565 49708143
Retching 62.97 13.41 80 889336 12782 49702926
Nystagmus 62.71 13.41 11 889405 5550 49710158
Catheter site infection 62.66 13.41 3 889413 4283 49711425
Atrioventricular block 62.66 13.41 18 889398 6460 49709248
Device power source issue 62.44 13.41 59 889357 438 49715270
Animal bite 62.02 13.41 132 889284 2235 49713473
Premature labour 61.98 13.41 66 889350 11410 49704298
Diplopia 61.67 13.41 156 889260 19104 49696604
Hypertriglyceridaemia 61.62 13.41 11 889405 5480 49710228
Abnormal dreams 61.40 13.41 45 889371 9332 49706376
Rib fracture 61.31 13.41 156 889260 19065 49696643
Depressed mood 61.08 13.41 349 889067 33674 49682034
Pulmonary haemorrhage 61.05 13.41 19 889397 6473 49709235
Cytomegalovirus viraemia 61.02 13.41 6 889410 4703 49711005
Panic attack 60.91 13.41 158 889258 19184 49696524
Diastolic dysfunction 60.87 13.41 10 889406 5292 49710416
Peripheral sensory neuropathy 60.72 13.41 20 889396 6571 49709137
Hepatitis 60.67 13.41 315 889101 31138 49684570
Left ventricular hypertrophy 60.67 13.41 7 889409 4838 49710870
Diverticulum intestinal 60.20 13.41 15 889401 5918 49709790
Petechiae 60.04 13.41 79 889337 12433 49703275
Hepatotoxicity 59.94 13.41 260 889156 26966 49688742
Duodenal ulcer 59.93 13.41 22 889394 6753 49708955
Cerebral ischaemia 59.82 13.41 15 889401 5893 49709815
Blood pressure diastolic increased 59.66 13.41 28 889388 7415 49708293
Discomfort 59.55 13.41 2400 887016 105980 49609728
Somnambulism 59.50 13.41 8 889408 4916 49710792
Coma scale abnormal 59.47 13.41 7 889409 4764 49710944
Aortic valve incompetence 59.26 13.41 12 889404 5464 49710244
Irritable bowel syndrome 59.11 13.41 1250 888166 50191 49665517
Abortion spontaneous 58.69 13.41 461 888955 41311 49674397
Elbow deformity 58.65 13.41 95 889321 1291 49714417
Partial seizures 58.56 13.41 8 889408 4857 49710851
Aplasia pure red cell 58.41 13.41 4 889412 4211 49711497
Application site erythema 58.24 13.41 6 889410 4532 49711176
Ankylosing spondylitis 58.10 13.41 265 889151 6900 49708808
Graft versus host disease 58.06 13.41 18 889398 6148 49709560
Hyperreflexia 57.99 13.41 10 889406 5108 49710600
Gallbladder operation 57.77 13.41 116 889300 1881 49713827
Low turnover osteopathy 57.74 13.41 3 889413 3991 49711717
Peritonitis bacterial 57.70 13.41 7 889409 4654 49711054
Oligohydramnios 57.45 13.41 15 889401 5735 49709973
Personality disorder 57.39 13.41 5 889411 4319 49711389
Product administration error 56.76 13.41 168 889248 19531 49696177
Iron deficiency anaemia 56.54 13.41 133 889283 16701 49699007
Injection site dryness 56.52 13.41 40 889376 185 49715523
Ketoacidosis 56.08 13.41 3 889413 3892 49711816
Prescribed overdose 56.02 13.41 107 889309 14493 49701215
Device occlusion 55.97 13.41 18 889398 6005 49709703
Nephropathy 55.92 13.41 12 889404 5246 49710462
Mental impairment 55.82 13.41 78 889338 11966 49703742
Paraesthesia oral 55.79 13.41 80 889336 12141 49703567
Protein urine present 55.72 13.41 13 889403 5364 49710344
Bundle branch block left 55.50 13.41 20 889396 6210 49709498
Maternal drugs affecting foetus 55.21 13.41 11 889405 5066 49710642
Hypoxic-ischaemic encephalopathy 55.19 13.41 3 889413 3839 49711869
Injection site hypoaesthesia 55.11 13.41 49 889367 333 49715375
Bundle branch block right 55.06 13.41 8 889408 4637 49711071
Major depression 55.02 13.41 26 889390 6858 49708850
Clonus 54.95 13.41 5 889411 4170 49711538
Elbow operation 54.88 13.41 42 889374 224 49715484
Potentiating drug interaction 54.75 13.41 3 889413 3813 49711895
Spinal compression fracture 54.72 13.41 86 889330 12570 49703138
Back pain 54.70 13.41 4534 884882 215496 49500212
Restless legs syndrome 54.68 13.41 124 889292 15773 49699935
Venous thrombosis 54.58 13.41 7 889409 4459 49711249
Electrocardiogram abnormal 54.51 13.41 33 889383 7572 49708136
Ventricular hypokinesia 54.51 13.41 4 889412 3976 49711732
Skin mass 54.27 13.41 206 889210 4929 49710779
Body height decreased 54.23 13.41 46 889370 8862 49706846
C-reactive protein increased 54.05 13.41 1541 887875 64933 49650775
Feeling hot 53.96 13.41 979 888437 38223 49677485
Upper respiratory tract congestion 53.82 13.41 107 889309 1722 49713986
Amnesia 53.67 13.41 479 888937 41781 49673927
Hypoventilation 53.53 13.41 4 889412 3917 49711791
Breast cancer metastatic 53.34 13.41 62 889354 10302 49705406
Stillbirth 53.20 13.41 19 889397 5933 49709775
Rheumatoid factor negative 53.14 13.41 59 889357 541 49715167
Neck surgery 53.01 13.41 95 889321 1408 49714300
Dermatitis bullous 53.01 13.41 30 889386 7143 49708565
Wheelchair user 52.99 13.41 200 889216 4772 49710936
Femoral neck fracture 52.99 13.41 33 889383 7457 49708251
Ileus paralytic 52.91 13.41 5 889411 4045 49711663
Pathogen resistance 52.87 13.41 17 889399 5672 49710036
Systemic inflammatory response syndrome 52.73 13.41 12 889404 5037 49710671
Product physical issue 52.43 13.41 7 889409 4325 49711383
Pre-existing condition improved 51.99 13.41 30 889386 7067 49708641
Diverticulum 51.98 13.41 66 889350 10548 49705160
Immune thrombocytopenia 51.97 13.41 49 889367 8968 49706740
Blood thyroid stimulating hormone increased 51.87 13.41 21 889395 6071 49709637
Erythema 51.84 13.41 3106 886310 143308 49572400
Gastroenteritis viral 51.50 13.41 531 888885 18255 49697453
Blood phosphorus decreased 51.35 13.41 4 889412 3785 49711923
Hypertransaminasaemia 51.31 13.41 3 889413 3608 49712100
Pseudomonas infection 51.19 13.41 54 889362 9376 49706332
Cataract operation 51.18 13.41 174 889242 3937 49711771
Kidney infection 50.97 13.41 529 888887 18217 49697491
Liver injury 50.96 13.41 243 889173 24563 49691145
Vascular device infection 50.93 13.41 8 889408 4376 49711332
Guttate psoriasis 50.93 13.41 46 889370 320 49715388
Joint surgery 50.92 13.41 45 889371 303 49715405
SLE arthritis 50.79 13.41 59 889357 571 49715137
Brain injury 50.77 13.41 21 889395 5993 49709715
Pyelonephritis 50.68 13.41 118 889298 14871 49700837
Drug level below therapeutic 50.54 13.41 4 889412 3736 49711972
Pulmonary fibrosis 50.53 13.41 654 888762 23783 49691925
Device dispensing error 50.50 13.41 28 889388 75 49715633
Intestinal perforation 50.45 13.41 66 889350 10413 49705295
Middle insomnia 50.37 13.41 60 889356 9861 49705847
Meniscus injury 50.30 13.41 232 889184 6070 49709638
Pruritus 50.25 13.41 5706 883710 277862 49437846
Cardiovascular disorder 50.17 13.41 66 889350 10388 49705320
Aortic arteriosclerosis 50.16 13.41 16 889400 5366 49710342
Surgical failure 50.16 13.41 71 889345 850 49714858
Proctalgia 50.08 13.41 13 889403 4990 49710718
Rhinovirus infection 50.02 13.41 3 889413 3531 49712177
Nocturia 49.94 13.41 28 889388 6702 49709006
Induration 49.86 13.41 77 889339 1002 49714706
Musculoskeletal discomfort 49.72 13.41 439 888977 14459 49701249
Tendon operation 49.70 13.41 42 889374 264 49715444
Azotaemia 49.67 13.41 6 889410 4002 49711706
International normalised ratio decreased 49.50 13.41 7 889409 4141 49711567
Blood chloride decreased 49.45 13.41 13 889403 4948 49710760
Gastrointestinal disorder 49.44 13.41 2081 887335 92375 49623333
Serum ferritin increased 49.32 13.41 15 889401 5187 49710521
Tenoplasty 49.29 13.41 17 889399 3 49715705
Hereditary angioedema 49.28 13.41 17 889399 5425 49710283
Blood glucose decreased 49.15 13.41 160 889256 18051 49697657
Hyperuricaemia 49.13 13.41 11 889405 4669 49711039
Gastric ulcer 49.04 13.41 200 889216 21105 49694603
Acute graft versus host disease 48.86 13.41 6 889410 3952 49711756
Metabolic disorder 48.76 13.41 16 889400 5270 49710438
Odynophagia 48.73 13.41 27 889389 6505 49709203
Supraventricular extrasystoles 48.64 13.41 6 889410 3938 49711770
Culture urine positive 48.64 13.41 3 889413 3448 49712260
Central nervous system lesion 48.59 13.41 57 889359 9432 49706276
Periorbital oedema 48.34 13.41 14 889402 4998 49710710
Eye operation 48.18 13.41 106 889310 1838 49713870
Vulvovaginal mycotic infection 48.12 13.41 182 889234 4347 49711361
Thrombocytosis 48.11 13.41 14 889402 4982 49710726
Endodontic procedure 48.08 13.41 131 889285 2615 49713093
Blood calcium increased 48.05 13.41 39 889377 7680 49708028
Cerebral atrophy 47.92 13.41 11 889405 4590 49711118
Haemorrhagic stroke 47.92 13.41 16 889400 5212 49710496
Catatonia 47.79 13.41 5 889411 3731 49711977
Pemphigoid 47.69 13.41 22 889394 5885 49709823
Blood culture positive 47.55 13.41 9 889407 4299 49711409
Toe operation 47.51 13.41 59 889357 616 49715092
Escherichia urinary tract infection 47.50 13.41 68 889348 10327 49705381
Post procedural haemorrhage 47.46 13.41 35 889381 7235 49708473
Lymphoma 47.29 13.41 310 889106 9291 49706417
Dyslipidaemia 47.27 13.41 23 889393 5965 49709743
Eye movement disorder 47.08 13.41 11 889405 4534 49711174
Iron deficiency 47.07 13.41 22 889394 5840 49709868
Oral mucosal exfoliation 46.84 13.41 92 889324 1467 49714241
Obsessive-compulsive disorder 46.78 13.41 3 889413 3337 49712371
Malignant melanoma 46.57 13.41 321 889095 9787 49705921
Tachyarrhythmia 46.56 13.41 8 889408 4097 49711611
Carpal tunnel decompression 46.53 13.41 62 889354 698 49715010
Exercise tolerance decreased 46.31 13.41 14 889402 4860 49710848
Back disorder 46.18 13.41 301 889115 9004 49706704
Throat tightness 45.94 13.41 199 889217 20648 49695060
Breast cancer female 45.76 13.41 240 889176 6622 49709086
Blister 45.64 13.41 1886 887530 83532 49632176
Unintended pregnancy 45.58 13.41 15 889401 4931 49710777
Ventricular septal defect 45.56 13.41 8 889408 4033 49711675
Bunion operation 45.51 13.41 76 889340 1061 49714647
Spinal column injury 45.51 13.41 99 889317 1703 49714005
Electrocardiogram T wave inversion 45.47 13.41 3 889413 3258 49712450
Ischaemia 45.31 13.41 10 889406 4287 49711421
Rhinitis allergic 45.29 13.41 36 889380 7164 49708544
Pre-eclampsia 44.87 13.41 45 889371 7999 49707709
Portal hypertension 44.81 13.41 4 889412 3388 49712320
Tongue oedema 44.61 13.41 7 889409 3832 49711876
Blood pressure inadequately controlled 44.58 13.41 11 889405 4369 49711339
Ammonia increased 44.45 13.41 10 889406 4231 49711477
Respiratory syncytial virus infection 44.40 13.41 17 889399 5085 49710623
Latent tuberculosis 44.37 13.41 112 889304 2131 49713577
Patent ductus arteriosus 44.32 13.41 7 889409 3813 49711895
Granuloma skin 44.11 13.41 211 889205 5607 49710101
Glycosylated haemoglobin increased 44.05 13.41 74 889342 10532 49705176
Candida infection 44.02 13.41 238 889178 23285 49692423
Diarrhoea haemorrhagic 43.89 13.41 42 889374 7633 49708075
Dyspnoea at rest 43.89 13.41 6 889410 3641 49712067
Non-cardiac chest pain 43.77 13.41 23 889393 5709 49709999
Cyst 43.76 13.41 365 889051 11822 49703886
Bone lesion 43.73 13.41 18 889398 5152 49710556
Euphoric mood 43.65 13.41 9 889407 4046 49711662
Blood thyroid stimulating hormone decreased 43.40 13.41 10 889406 4162 49711546
Dermatitis exfoliative 43.33 13.41 18 889398 5124 49710584
Peripheral ischaemia 43.02 13.41 11 889405 4265 49711443
Brain natriuretic peptide increased 43.02 13.41 13 889403 4514 49711194
Blood creatine increased 43.01 13.41 16 889400 4871 49710837
Respiratory rate decreased 42.92 13.41 3 889413 3105 49712603
Dermatitis atopic 42.92 13.41 6 889410 3580 49712128
Colitis ulcerative 42.81 13.41 152 889264 16702 49699006
Blood prolactin increased 42.77 13.41 3 889413 3096 49712612
Physical disability 42.74 13.41 98 889318 1749 49713959
Personality change 42.60 13.41 23 889393 5622 49710086
Sensory disturbance 42.56 13.41 90 889326 11739 49703969
Splenomegaly 42.38 13.41 65 889351 9595 49706113
Left ventricular failure 42.35 13.41 16 889400 4825 49710883
Bedridden 42.29 13.41 296 889120 9071 49706637
Injection site exfoliation 42.19 13.41 34 889382 198 49715510
Injection site coldness 42.15 13.41 23 889393 59 49715649
Oxygen consumption increased 42.12 13.41 6 889410 3530 49712178
Infection susceptibility increased 42.02 13.41 120 889296 2464 49713244
Breath sounds abnormal 41.87 13.41 45 889371 7747 49707961
Pneumonia fungal 41.79 13.41 12 889404 4308 49711400
Wrong product administered 41.69 13.41 21 889395 5339 49710369
Hydrocephalus 41.59 13.41 16 889400 4772 49710936
Local reaction 41.59 13.41 51 889365 525 49715183
Pollakiuria 41.56 13.41 247 889169 23604 49692104
Pulmonary arterial pressure increased 41.52 13.41 5 889411 3343 49712365
Rebound effect 41.49 13.41 4 889412 3185 49712523
Embolic stroke 41.30 13.41 6 889410 3478 49712230
Amenorrhoea 41.29 13.41 53 889363 8431 49707277
Panniculitis 40.95 13.41 273 889143 8230 49707478
Thirst 40.91 13.41 78 889338 10572 49705136
Blood parathyroid hormone decreased 40.89 13.41 239 889177 6875 49708833
Sensitivity to weather change 40.79 13.41 211 889205 5790 49709918
Hot flush 40.69 13.41 539 888877 43630 49672078
Cardiac murmur 40.54 13.41 80 889336 10704 49705004
Laryngeal oedema 40.51 13.41 19 889397 5034 49710674
Hypogammaglobulinaemia 40.47 13.41 25 889391 5674 49710034
Urticaria 40.10 13.41 2717 886699 126844 49588864
Staphylococcus test positive 40.06 13.41 6 889410 3400 49712308
Platelet count increased 39.76 13.41 127 889289 14413 49701295
Drooling 39.72 13.41 6 889410 3378 49712330
Respiration abnormal 39.67 13.41 20 889396 5082 49710626
Bone swelling 39.54 13.41 74 889342 1136 49714572
Pain in jaw 39.52 13.41 458 888958 37970 49677738
Lung consolidation 39.45 13.41 9 889407 3771 49711937
Eye infection 39.44 13.41 292 889124 9114 49706594
Tooth abscess 39.39 13.41 372 889044 12488 49703220
Systemic lupus erythematosus rash 39.39 13.41 92 889324 1663 49714045
Skin laceration 39.27 13.41 505 888911 18337 49697371
Depressive symptom 39.14 13.41 5 889411 3195 49712513
Lip oedema 39.03 13.41 5 889411 3188 49712520
Progressive multifocal leukoencephalopathy 38.89 13.41 90 889326 11367 49704341
Embolism 38.84 13.41 39 889377 6929 49708779
Protein total decreased 38.81 13.41 22 889394 5234 49710474
Cardiac tamponade 38.71 13.41 13 889403 4219 49711489
Diverticulitis 38.67 13.41 808 888608 32374 49683334
Gastritis erosive 38.62 13.41 21 889395 5113 49710595
Thrombotic thrombocytopenic purpura 38.50 13.41 8 889408 3577 49712131
Macular degeneration 38.42 13.41 127 889289 14261 49701447
Flank pain 38.40 13.41 111 889305 13004 49702704
Tumour marker increased 38.40 13.41 10 889406 3830 49711878
Joint dislocation 38.40 13.41 358 889058 11975 49703733
Malabsorption 38.32 13.41 9 889407 3697 49712011
Drug abuser 38.28 13.41 3 889413 2825 49712883
Sexual dysfunction 38.26 13.41 6 889410 3286 49712422
Dental care 38.25 13.41 63 889353 869 49714839
Lung transplant 38.23 13.41 3 889413 2822 49712886
Red cell distribution width increased 38.12 13.41 57 889359 8502 49707206
Immune reconstitution inflammatory syndrome 38.07 13.41 25 889391 5491 49710217
Cachexia 37.99 13.41 16 889400 4517 49711191
Muscle twitching 37.99 13.41 141 889275 15290 49700418
Polydipsia 37.93 13.41 5 889411 3119 49712589
Application site pain 37.77 13.41 10 889406 3788 49711920
Muscle haemorrhage 37.73 13.41 4 889412 2954 49712754
Weight fluctuation 37.62 13.41 42 889374 7106 49708602
Pathological fracture 37.38 13.41 48 889368 7634 49708074
Large intestine perforation 37.33 13.41 46 889370 7448 49708260
Streptococcal infection 37.31 13.41 174 889242 4574 49711134
Coordination abnormal 37.26 13.41 93 889323 11441 49704267
Movement disorder 37.23 13.41 171 889245 17461 49698247
Sciatica 37.22 13.41 555 888861 20827 49694881
Dental operation 37.17 13.41 68 889348 1025 49714683
Lymphocyte percentage decreased 37.16 13.41 3 889413 2757 49712951
Endophthalmitis 37.05 13.41 4 889412 2912 49712796
White blood cells urine positive 37.04 13.41 17 889399 4561 49711147
Haemophagocytic lymphohistiocytosis 37.01 13.41 59 889357 8574 49707134
Incoherent 36.97 13.41 14 889402 4216 49711492
Contrast media allergy 36.79 13.41 98 889318 1929 49713779
Neutrophil percentage increased 36.62 13.41 3 889413 2724 49712984
Pelvic pain 36.54 13.41 90 889326 11123 49704585
Urine leukocyte esterase positive 36.52 13.41 4 889412 2879 49712829
Multiple-drug resistance 36.42 13.41 7 889409 3307 49712401
Cerebellar syndrome 36.37 13.41 7 889409 3304 49712404
Abdominal wall haematoma 36.30 13.41 3 889413 2705 49713003
Skin hyperpigmentation 36.29 13.41 24 889392 5252 49710456
Spider vein 36.17 13.41 33 889383 233 49715475
Carpal tunnel syndrome 36.15 13.41 455 888961 16438 49699270
Neurogenic bladder 36.10 13.41 4 889412 2853 49712855
Device defective 36.01 13.41 74 889342 1221 49714487
Vitamin D deficiency 36.01 13.41 93 889323 11309 49704399
Purpura 36.00 13.41 75 889341 9836 49705872
Injection site pustule 35.96 13.41 20 889396 54 49715654
Injection site anaesthesia 35.94 13.41 17 889399 28 49715680
Nasal discharge discolouration 35.78 13.41 81 889335 1433 49714275
Drug screen positive 35.70 13.41 8 889408 3394 49712314
Intracranial pressure increased 35.65 13.41 15 889401 4237 49711471
Fluid intake reduced 35.59 13.41 6 889410 3116 49712592
Blindness 35.57 13.41 169 889247 17100 49698608
Scleritis 35.38 13.41 131 889285 3096 49712612
Hypokinesia 35.33 13.41 104 889312 12113 49703595
Exposed bone in jaw 35.17 13.41 4 889412 2796 49712912
Ventricular hypertrophy 34.89 13.41 7 889409 3208 49712500
Scab 34.87 13.41 216 889200 6346 49709362
Papule 34.71 13.41 160 889256 4185 49711523
Arthropod sting 34.67 13.41 57 889359 785 49714923
Skin reaction 34.62 13.41 333 889083 11235 49704473
Anger 34.60 13.41 94 889322 11239 49704469
Performance status decreased 34.58 13.41 7 889409 3188 49712520
Cystitis haemorrhagic 34.51 13.41 11 889405 3691 49712017
Neutrophilia 34.46 13.41 10 889406 3565 49712143
Disturbance in social behaviour 34.27 13.41 5 889411 2889 49712819
Phlebitis 34.26 13.41 30 889386 5690 49710018
Stridor 34.18 13.41 7 889409 3162 49712546
Animal scratch 34.15 13.41 59 889357 848 49714860
Focal dyscognitive seizures 34.08 13.41 4 889412 2728 49712980
Occult blood positive 34.02 13.41 8 889408 3283 49712425
Post procedural infection 33.97 13.41 239 889177 7337 49708371
Urine analysis abnormal 33.90 13.41 17 889399 4333 49711375
Temperature regulation disorder 33.73 13.41 16 889400 4211 49711497
Biliary dyskinesia 33.71 13.41 3 889413 2547 49713161
Extrasystoles 33.64 13.41 20 889396 4635 49711073
Thrombophlebitis 33.61 13.41 14 889402 3979 49711729
Stress at work 33.40 13.41 64 889352 1001 49714707
Wrist deformity 33.38 13.41 88 889328 1721 49713987
Escherichia bacteraemia 33.37 13.41 7 889409 3109 49712599
Fracture 33.36 13.41 167 889249 16666 49699042
Necrosis 33.32 13.41 21 889395 4715 49710993
Therapy partial responder 33.31 13.41 40 889376 6551 49709157
Rotator cuff repair 33.23 13.41 85 889331 1631 49714077
Skin swelling 33.13 13.41 98 889318 2054 49713654
Galactorrhoea 33.08 13.41 12 889404 3711 49711997
Sinus node dysfunction 33.08 13.41 14 889402 3941 49711767
Blood uric acid increased 33.00 13.41 13 889403 3821 49711887
Ocular icterus 32.98 13.41 10 889406 3465 49712243
Hyperventilation 32.84 13.41 28 889388 5381 49710327
Neonatal respiratory distress syndrome 32.82 13.41 4 889412 2650 49713058
Intermenstrual bleeding 32.72 13.41 43 889373 6771 49708937
Blood chloride increased 32.69 13.41 3 889413 2485 49713223
Gallbladder disorder 32.67 13.41 167 889249 16575 49699133
Hepatitis fulminant 32.63 13.41 7 889409 3061 49712647
Gastrointestinal perforation 32.53 13.41 7 889409 3054 49712654
Psychiatric symptom 32.52 13.41 20 889396 4550 49711158
Pulmonary alveolar haemorrhage 32.51 13.41 15 889401 4012 49711696
Coronary artery occlusion 32.42 13.41 51 889365 7452 49708256
Red blood cells urine positive 32.39 13.41 5 889411 2770 49712938
Hyperpyrexia 32.34 13.41 7 889409 3042 49712666
Pericarditis 32.25 13.41 1692 887724 76997 49638711
Low density lipoprotein increased 32.17 13.41 31 889385 5615 49710093
Injection site plaque 32.10 13.41 19 889397 60 49715648
Metastases to lymph nodes 32.04 13.41 46 889370 6978 49708730
Injection site discharge 32.02 13.41 38 889378 377 49715331
Abdominal tenderness 31.92 13.41 49 889367 7231 49708477
Lupus-like syndrome 31.84 13.41 280 889136 9211 49706497
Congestive cardiomyopathy 31.79 13.41 30 889386 5488 49710220
Swelling face 31.76 13.41 693 888723 51902 49663806
Pyelonephritis acute 31.75 13.41 16 889400 4067 49711641
Pulmonary function test decreased 31.71 13.41 10 889406 3378 49712330
Injection site scar 31.67 13.41 55 889361 794 49714914
Occupational exposure to product 31.64 13.41 86 889330 1714 49713994
Chronic graft versus host disease 31.62 13.41 6 889410 2861 49712847
Endocarditis 31.55 13.41 26 889390 5081 49710627
Intervertebral disc operation 31.51 13.41 47 889369 592 49715116
Fibrin D dimer increased 31.38 13.41 18 889398 4254 49711454
Injection site cellulitis 31.34 13.41 66 889350 1109 49714599
Knee deformity 31.33 13.41 61 889355 966 49714742
Renal cyst 31.33 13.41 66 889350 8621 49707087
Myositis 31.31 13.41 57 889359 7863 49707845
Rash morbilliform 31.30 13.41 6 889410 2840 49712868
Retinal haemorrhage 31.29 13.41 21 889395 4560 49711148
International normalised ratio abnormal 31.25 13.41 6 889410 2837 49712871
Human antichimeric antibody positive 31.20 13.41 76 889340 1413 49714295
Body temperature abnormal 31.19 13.41 69 889347 1201 49714507
Prescribed underdose 31.17 13.41 159 889257 15790 49699918
Pruritus allergic 31.14 13.41 64 889352 1056 49714652
Colonoscopy 31.05 13.41 72 889344 1295 49714413
Plasmacytoma 31.01 13.41 3 889413 2382 49713326
Insurance issue 30.98 13.41 107 889309 2441 49713267
Product administered at inappropriate site 30.94 13.41 104 889312 2339 49713369
Behaviour disorder 30.93 13.41 3 889413 2377 49713331
Mammoplasty 30.87 13.41 41 889375 460 49715248
Nail disorder 30.83 13.41 283 889133 9425 49706283
Cardiac failure chronic 30.80 13.41 12 889404 3551 49712157
Device difficult to use 30.79 13.41 287 889129 9599 49706109
Neoplasm recurrence 30.75 13.41 3 889413 2366 49713342
Periodontitis 30.67 13.41 8 889408 3061 49712647
Ear congestion 30.63 13.41 91 889325 1912 49713796
Epidural injection 30.59 13.41 10 889406 0 49715708
Disability assessment scale score increased 30.57 13.41 3 889413 2355 49713353
Bacterial test positive 30.49 13.41 23 889393 4700 49711008
Initial insomnia 30.42 13.41 27 889389 5088 49710620
Accident 30.38 13.41 174 889242 4967 49710741
Pseudomembranous colitis 30.36 13.41 6 889410 2779 49712929
Hip fracture 30.32 13.41 300 889116 25631 49690077
Areflexia 30.28 13.41 6 889410 2774 49712934
Petit mal epilepsy 30.26 13.41 10 889406 3279 49712429
Body height below normal 30.23 13.41 89 889327 1860 49713848
Urine ketone body present 30.16 13.41 3 889413 2330 49713378
Mass excision 30.16 13.41 30 889386 239 49715469
Hypoglycaemic coma 30.16 13.41 3 889413 2330 49713378
Upper-airway cough syndrome 30.13 13.41 255 889161 8295 49707413
Skin fissures 29.74 13.41 257 889159 8411 49707297
Product label confusion 29.62 13.41 41 889375 480 49715228
Self-medication 29.61 13.41 3 889413 2296 49713412
Lack of injection site rotation 29.45 13.41 31 889385 266 49715442
Orthosis user 29.43 13.41 19 889397 73 49715635
Joint laxity 29.42 13.41 101 889315 2297 49713411
Blood phosphorus increased 29.35 13.41 5 889411 2577 49713131
Carotid artery stenosis 29.33 13.41 24 889392 4707 49711001
Bilirubin conjugated increased 29.27 13.41 4 889412 2428 49713280
Lymphoedema 29.12 13.41 74 889342 9048 49706660
Lacunar infarction 29.09 13.41 9 889407 3078 49712630
Cold sweat 29.08 13.41 93 889323 10551 49705157
Drug tolerance decreased 29.07 13.41 267 889149 8893 49706815
Fungal infection 29.07 13.41 711 888705 29254 49686454
Ankle arthroplasty 29.06 13.41 63 889353 1081 49714627
Jugular vein thrombosis 28.99 13.41 6 889410 2690 49713018
Haemoperitoneum 28.93 13.41 5 889411 2550 49713158
Escherichia infection 28.92 13.41 97 889319 10844 49704864
Eating disorder 28.78 13.41 156 889260 15253 49700455
Eyelid ptosis 28.74 13.41 40 889376 6147 49709561
Dental implantation 28.74 13.41 44 889372 568 49715140
Staphylococcal bacteraemia 28.70 13.41 26 889390 4851 49710857
Dysphoria 28.64 13.41 25 889391 4749 49710959
Gastrointestinal sounds abnormal 28.62 13.41 14 889402 3620 49712088
Persecutory delusion 28.55 13.41 4 889412 2383 49713325
Live birth 28.55 13.41 170 889246 16238 49699470
Pneumonia bacterial 28.54 13.41 53 889363 7256 49708452
Paranasal sinus discomfort 28.49 13.41 116 889300 2870 49712838
Hypoaesthesia oral 28.43 13.41 95 889321 10633 49705075
Inflammatory marker increased 28.42 13.41 183 889233 5451 49710257
Haemarthrosis 28.28 13.41 8 889408 2900 49712808
Duodenitis 28.26 13.41 11 889405 3257 49712451
Exposure to communicable disease 28.19 13.41 41 889375 504 49715204
Diabetic retinopathy 28.16 13.41 3 889413 2207 49713501
Cardiopulmonary failure 28.12 13.41 12 889404 3361 49712347
Tooth extraction 28.04 13.41 263 889153 8812 49706896
Subileus 27.94 13.41 7 889409 2752 49712956
Ventricular dysfunction 27.84 13.41 6 889410 2615 49713093
Nerve injury 27.84 13.41 246 889170 8104 49707604
Mucormycosis 27.81 13.41 5 889411 2478 49713230
Caesarean section 27.76 13.41 161 889255 15478 49700230
Malignant pleural effusion 27.65 13.41 4 889412 2326 49713382
Coronary artery stenosis 27.55 13.41 21 889395 4268 49711440
Cytomegalovirus test positive 27.39 13.41 6 889410 2586 49713122
Ischaemic cardiomyopathy 27.36 13.41 4 889412 2308 49713400
Urine abnormality 27.34 13.41 42 889374 6196 49709512
Nasal ulcer 27.21 13.41 78 889338 1605 49714103
Oral surgery 27.21 13.41 57 889359 954 49714754
Visual field defect 27.21 13.41 37 889379 5742 49709966
Maternal exposure before pregnancy 27.20 13.41 35 889381 5562 49710146
Nail pitting 27.15 13.41 27 889389 215 49715493
Hepatitis toxic 26.92 13.41 8 889408 2808 49712900
Systemic infection 26.90 13.41 4 889412 2279 49713429
Laryngospasm 26.88 13.41 7 889409 2681 49713027
Small for dates baby 26.86 13.41 14 889402 3491 49712217
Breast cancer stage III 26.83 13.41 121 889295 3135 49712573
Conjunctival haemorrhage 26.73 13.41 10 889406 3034 49712674
Arterial occlusive disease 26.70 13.41 27 889389 4781 49710927
Neurological decompensation 26.70 13.41 4 889412 2266 49713442
Enthesopathy 26.67 13.41 217 889199 6976 49708732
Peripheral coldness 26.62 13.41 92 889324 10191 49705517
Sarcoidosis 26.57 13.41 165 889251 4852 49710856
Obstruction 26.56 13.41 3 889413 2108 49713600
Increased appetite 26.55 13.41 68 889348 8293 49707415
Product dose omission in error 26.52 13.41 5 889411 2395 49713313
Ovarian neoplasm 26.48 13.41 51 889365 801 49714907
Post transplant lymphoproliferative disorder 26.47 13.41 21 889395 4183 49711525
Thyroid neoplasm 26.45 13.41 127 889289 3380 49712328
Dry mouth 26.43 13.41 768 888648 55410 49660298
Eyelid oedema 26.36 13.41 82 889334 9384 49706324
Aortic stenosis 26.35 13.41 21 889395 4173 49711535
Clostridial infection 26.32 13.41 19 889397 3971 49711737
Autonomic nervous system imbalance 26.29 13.41 5 889411 2380 49713328
Leukoencephalopathy 26.26 13.41 18 889398 3865 49711843
Cholangitis 26.25 13.41 25 889391 4554 49711154
General symptom 26.19 13.41 99 889317 2364 49713344
Female genital tract fistula 26.15 13.41 16 889400 3650 49712058
Self-injurious ideation 26.05 13.41 4 889412 2225 49713483
Juvenile idiopathic arthritis 26.02 13.41 110 889306 2769 49712939
Immobile 26.01 13.41 165 889251 4889 49710819
Macular oedema 25.99 13.41 16 889400 3638 49712070
Onychomadesis 25.91 13.41 127 889289 3409 49712299
Urinary tract infection bacterial 25.91 13.41 21 889395 4138 49711570
Investigation abnormal 25.90 13.41 64 889352 1201 49714507
Blood immunoglobulin E increased 25.89 13.41 5 889411 2354 49713354
Thinking abnormal 25.85 13.41 84 889332 9483 49706225
Loose body in joint 25.84 13.41 62 889354 1141 49714567
Blood parathyroid hormone increased 25.70 13.41 9 889407 2845 49712863
Microcytic anaemia 25.66 13.41 11 889405 3073 49712635
Burn infection 25.64 13.41 14 889402 36 49715672
Rotator cuff syndrome 25.59 13.41 313 889103 11231 49704477
Wound dehiscence 25.58 13.41 23 889393 4307 49711401
Escherichia sepsis 25.51 13.41 23 889393 4301 49711407
Large intestinal ulcer 25.45 13.41 11 889405 3058 49712650
Mass 25.40 13.41 326 889090 11831 49703877
Dilatation ventricular 25.36 13.41 5 889411 2320 49713388
Spinal cord compression 25.34 13.41 17 889399 3692 49712016
Hangnail 25.29 13.41 11 889405 13 49715695
Hepatic lesion 25.26 13.41 20 889396 3988 49711720
Menopause 25.13 13.41 94 889322 2233 49713475
Adjustment disorder 25.07 13.41 3 889413 2016 49713692
Duodenal ulcer haemorrhage 25.06 13.41 4 889412 2162 49713546
Pulmonary thrombosis 24.99 13.41 60 889356 7481 49708227
Social avoidant behaviour 24.88 13.41 9 889407 2788 49712920
Anxiety disorder 24.87 13.41 17 889399 3656 49712052
Ligament rupture 24.87 13.41 102 889314 2532 49713176
Epicondylitis 24.83 13.41 82 889334 1827 49713881
Eczema 24.75 13.41 267 889149 22435 49693273
Acute graft versus host disease in skin 24.74 13.41 11 889405 3007 49712701
Tonsillar ulcer 24.72 13.41 28 889388 263 49715445
Urinary sediment present 24.62 13.41 3 889413 1988 49713720
Injection site infection 24.55 13.41 75 889341 1601 49714107
Normochromic normocytic anaemia 24.52 13.41 22 889394 4124 49711584
Hypertensive heart disease 24.51 13.41 5 889411 2265 49713443
Communication disorder 24.38 13.41 5 889411 2256 49713452
Lung opacity 24.34 13.41 3 889413 1970 49713738
Refusal of treatment by patient 24.15 13.41 32 889384 5021 49710687
Pseudomonal sepsis 24.13 13.41 4 889412 2103 49713605
Cutaneous vasculitis 24.08 13.41 145 889271 4217 49711491
Oral pain 23.97 13.41 303 889113 24730 49690978
Abnormal faeces 23.95 13.41 23 889393 4173 49711535
Cyst removal 23.92 13.41 33 889383 385 49715323
Scar excision 23.92 13.41 13 889403 33 49715675
Pharyngeal swelling 23.84 13.41 27 889389 4539 49711169
Faeces soft 23.76 13.41 22 889394 4062 49711646
Intra-abdominal haemorrhage 23.75 13.41 5 889411 2215 49713493
Epstein-Barr virus infection 23.72 13.41 55 889361 6942 49708766
Butterfly rash 23.71 13.41 61 889355 1175 49714533
Bone graft 23.68 13.41 48 889368 784 49714924
Skin injury 23.59 13.41 71 889345 1503 49714205
Clostridium test positive 23.58 13.41 4 889412 2068 49713640
Osteoporosis 23.52 13.41 989 888427 43890 49671818
Infected bite 23.48 13.41 65 889351 1310 49714398
Spinal osteoarthritis 23.48 13.41 148 889268 13944 49701764
Heavy menstrual bleeding 23.47 13.41 168 889248 15369 49700339
Paraparesis 23.46 13.41 4 889412 2060 49713648
Reaction to preservatives 23.43 13.41 23 889393 180 49715528
Oesophageal pain 23.31 13.41 10 889406 2792 49712916
Injection site erosion 23.26 13.41 16 889400 70 49715638
Haemolytic uraemic syndrome 23.26 13.41 6 889410 2313 49713395
Alcohol abuse 23.18 13.41 3 889413 1898 49713810
Dysaesthesia 23.09 13.41 19 889397 3716 49711992
Arthroscopic surgery 23.04 13.41 12 889404 27 49715681
Hepatic cyst 22.99 13.41 27 889389 4466 49711242
Oral herpes 22.96 13.41 501 888915 20224 49695484
Throat irritation 22.93 13.41 695 888721 29544 49686164
Periorbital swelling 22.80 13.41 3 889413 1874 49713834
Disease recurrence 22.78 13.41 234 889182 19847 49695861
Red cell distribution width decreased 22.73 13.41 56 889360 1049 49714659
Intraventricular haemorrhage 22.69 13.41 3 889413 1867 49713841
Product distribution issue 22.51 13.41 43 889373 671 49715037
Extravasation 22.49 13.41 4 889412 1998 49713710
Anal fistula 22.47 13.41 10 889406 2732 49712976
Dermatitis allergic 22.46 13.41 331 889085 12389 49703319
Intramedullary rod insertion 22.46 13.41 4 889412 1996 49713712
Essential hypertension 22.43 13.41 27 889389 4417 49711291
Night sweats 22.42 13.41 760 888656 32814 49682894
Injection related reaction 22.41 13.41 39 889377 564 49715144
Skin papilloma 22.34 13.41 139 889277 4090 49711618
Device related sepsis 22.34 13.41 17 889399 3458 49712250
Arthritis infective 22.29 13.41 171 889245 5398 49710310
Compression fracture 22.20 13.41 43 889373 5794 49709914
Biliary colic 22.18 13.41 15 889401 3244 49712464
Internal haemorrhage 22.12 13.41 27 889389 4390 49711318
Paralysis 22.10 13.41 78 889338 8586 49707122
Hysterectomy 22.09 13.41 224 889192 7666 49708042
Dry eye 22.07 13.41 729 888687 31366 49684342
Hypoproteinaemia 22.06 13.41 3 889413 1828 49713880
Gastrointestinal necrosis 22.05 13.41 9 889407 2589 49713119
Escherichia test positive 22.02 13.41 5 889411 2102 49713606
Synovial cyst 21.99 13.41 230 889186 7936 49707772
Haemothorax 21.93 13.41 4 889412 1962 49713746
Growth failure 21.88 13.41 28 889388 302 49715406
Acute psychosis 21.79 13.41 6 889410 2214 49713494
Prosthesis user 21.75 13.41 15 889401 66 49715642
Staphylococcal infection 21.75 13.41 798 888618 34818 49680890
Vascular access complication 21.72 13.41 56 889360 1080 49714628
Decreased activity 21.72 13.41 36 889380 5151 49710557
Appendicitis 21.72 13.41 53 889363 6571 49709137
Cell death 21.71 13.41 6 889410 2209 49713499
Portal vein thrombosis 21.67 13.41 6 889410 2206 49713502
Lactose intolerance 21.65 13.41 9 889407 2561 49713147
Mucous stools 21.64 13.41 12 889404 2890 49712818
Hypertonic bladder 21.53 13.41 13 889403 2987 49712721
Hypercalcaemia 21.49 13.41 285 889131 23067 49692641
Gout 21.49 13.41 116 889300 11354 49704354
Bipolar disorder 21.42 13.41 55 889361 6702 49709006
Rheumatoid lung 21.37 13.41 93 889323 2372 49713336
Seronegative arthritis 21.22 13.41 82 889334 1979 49713729
Feeling cold 21.18 13.41 230 889186 19301 49696407
Hyperaemia 21.16 13.41 5 889411 2045 49713663
Hypopnoea 21.05 13.41 7 889409 2286 49713422
Maternal exposure during pregnancy 21.04 13.41 2472 886944 157306 49558402
Haemoglobin abnormal 21.02 13.41 28 889388 4384 49711324
Dissociation 21.02 13.41 7 889409 2284 49713424
Glaucoma 20.98 13.41 390 889026 15296 49700412
Generalised oedema 20.97 13.41 148 889268 13583 49702125
Eosinophilic pneumonia 20.97 13.41 4 889412 1900 49713808
Tenderness 20.96 13.41 450 888966 18115 49697593
Oral candidiasis 20.92 13.41 193 889223 16722 49698986
Blood sodium increased 20.91 13.41 8 889408 2394 49713314
Gastric ulcer haemorrhage 20.82 13.41 29 889387 4455 49711253
Bradyarrhythmia 20.75 13.41 4 889412 1886 49713822
Procedural haemorrhage 20.74 13.41 8 889408 2382 49713326
Affective disorder 20.74 13.41 37 889379 5144 49710564
Monocyte count decreased 20.69 13.41 4 889412 1882 49713826
Motor dysfunction 20.69 13.41 72 889344 7959 49707749
Bruxism 20.68 13.41 14 889402 3026 49712682
Micturition urgency 20.68 13.41 75 889341 8189 49707519
Crohn's disease 20.62 13.41 32 889384 4701 49711007
Metastasis 20.61 13.41 28 889388 4347 49711361
Autoimmune haemolytic anaemia 20.50 13.41 24 889392 3975 49711733
Left atrial dilatation 20.49 13.41 3 889413 1729 49713979
Liver transplant 20.48 13.41 6 889410 2126 49713582
Off label use 20.44 13.41 7764 881652 466662 49249046
Mood altered 20.34 13.41 136 889280 12637 49703071
Large intestinal stenosis 20.33 13.41 3 889413 1719 49713989
Alcohol use 20.33 13.41 5 889411 1990 49713718
Miliaria 20.32 13.41 49 889367 905 49714803
Reversible cerebral vasoconstriction syndrome 20.29 13.41 6 889410 2113 49713595
Basal cell carcinoma 20.25 13.41 546 888870 22810 49692898
Arteriospasm coronary 20.18 13.41 18 889398 3384 49712324
Anaemia postoperative 20.17 13.41 6 889410 2105 49713603
Colitis microscopic 20.16 13.41 189 889227 6331 49709377
Organ failure 20.14 13.41 8 889408 2340 49713368
Intervertebral disc protrusion 20.11 13.41 485 888931 19908 49695800
Gastrointestinal motility disorder 20.11 13.41 30 889386 4479 49711229
Pneumonia klebsiella 20.07 13.41 5 889411 1973 49713735
Choking 20.05 13.41 79 889337 8419 49707289
X-ray abnormal 19.97 13.41 96 889320 2556 49713152
Lymph node pain 19.96 13.41 59 889357 1236 49714472
Nocardiosis 19.95 13.41 3 889413 1695 49714013
Hypochromic anaemia 19.92 13.41 3 889413 1693 49714015
Staphylococcal skin infection 19.90 13.41 43 889373 736 49714972
Haemorrhoidal haemorrhage 19.90 13.41 21 889395 3646 49712062
Iridocyclitis 19.87 13.41 80 889336 1969 49713739
Mean cell volume increased 19.80 13.41 14 889402 2958 49712750
Transaminases abnormal 19.80 13.41 36 889380 540 49715168
Rash macular 19.79 13.41 461 888955 18816 49696892
Fibrosis 19.74 13.41 22 889394 3725 49711983
Disease susceptibility 19.62 13.41 21 889395 184 49715524
JC virus infection 19.60 13.41 4 889412 1811 49713897
Sensory loss 19.51 13.41 70 889346 7668 49708040
Non-small cell lung cancer 19.35 13.41 14 889402 2923 49712785
Rocky mountain spotted fever 19.34 13.41 10 889406 22 49715686
Metastases to peritoneum 19.34 13.41 13 889403 2820 49712888
Proctitis 19.32 13.41 5 889411 1923 49713785
Troponin I increased 19.29 13.41 5 889411 1921 49713787
Herpes simplex 19.27 13.41 63 889353 7099 49708609
Pulmonary infarction 19.25 13.41 9 889407 2389 49713319
Dermatitis exfoliative generalised 19.20 13.41 16 889400 3110 49712598
Retinal toxicity 19.15 13.41 55 889361 1133 49714575
Upper respiratory tract inflammation 19.13 13.41 9 889407 2380 49713328
Dactylitis 19.13 13.41 74 889342 1787 49713921
Haemoglobin increased 19.07 13.41 16 889400 3099 49712609
Anaphylactoid reaction 19.06 13.41 19 889397 3387 49712321
Angle closure glaucoma 19.04 13.41 6 889410 2028 49713680
Immunosuppression 18.99 13.41 207 889209 7219 49708489
Skin disorder 18.95 13.41 555 888861 23475 49692233
Polycystic ovaries 18.92 13.41 10 889406 2474 49713234
Infected cyst 18.88 13.41 44 889372 794 49714914
Vulvovaginal candidiasis 18.85 13.41 12 889404 2680 49713028
Oesophageal candidiasis 18.81 13.41 37 889379 4957 49710751
Spinal nerve stimulator implantation 18.79 13.41 15 889401 86 49715622
Cerebrovascular disorder 18.74 13.41 11 889405 2567 49713141
Atrial tachycardia 18.73 13.41 7 889409 2125 49713583
Carbohydrate antigen 125 increased 18.69 13.41 10 889406 2457 49713251
Enuresis 18.69 13.41 7 889409 2122 49713586
Drug effective for unapproved indication 18.68 13.41 6 889410 2003 49713705
Intestinal haemorrhage 18.66 13.41 17 889399 3163 49712545
Feeling drunk 18.64 13.41 22 889394 3631 49712077
Helicobacter infection 18.64 13.41 1060 888356 48642 49667066
Acute lymphocytic leukaemia 18.64 13.41 8 889408 2233 49713475
Product preparation error 18.63 13.41 30 889386 4342 49711366
Neutrophil count abnormal 18.58 13.41 10 889406 2449 49713259
Metastases to meninges 18.57 13.41 6 889410 1996 49713712
Spinal stenosis 18.51 13.41 338 889078 13212 49702496
Bone disorder 18.50 13.41 446 888970 18306 49697402
Humerus fracture 18.50 13.41 70 889346 7548 49708160
Hepatorenal syndrome 18.49 13.41 4 889412 1739 49713969
Polyarthritis 18.48 13.41 217 889199 7710 49707998
Appetite disorder 18.45 13.41 51 889365 6063 49709645
Pharyngeal operation 18.35 13.41 6 889410 0 49715708
Gastric haemorrhage 18.34 13.41 46 889370 5650 49710058
Diffuse large B-cell lymphoma recurrent 18.33 13.41 3 889413 1592 49714116
Blood immunoglobulin G decreased 18.33 13.41 6 889410 1979 49713729
Infiltration anaesthesia 18.32 13.41 18 889398 141 49715567
Synovectomy 18.31 13.41 19 889397 160 49715548
Autoimmune hepatitis 18.31 13.41 69 889347 7450 49708258
Tenosynovitis 18.30 13.41 274 889142 10291 49705417
Compartment syndrome 18.28 13.41 6 889410 1976 49713732
Haematocrit increased 18.17 13.41 6 889410 1968 49713740
Rash pustular 18.15 13.41 184 889232 6297 49709411
Sudden cardiac death 18.14 13.41 6 889410 1966 49713742
Sensitisation 18.13 13.41 3 889413 1579 49714129
Sunburn 18.11 13.41 87 889329 2316 49713392
Malignant neoplasm of conjunctiva 18.09 13.41 11 889405 37 49715671
Blood glucose fluctuation 18.09 13.41 28 889388 4118 49711590
Hearing aid user 18.06 13.41 12 889404 49 49715659
Product administered to patient of inappropriate age 18.04 13.41 12 889404 2618 49713090
Hepatosplenic T-cell lymphoma 18.03 13.41 35 889381 553 49715155
Hyperparathyroidism 17.98 13.41 10 889406 2404 49713304
Electric shock 17.96 13.41 49 889367 979 49714729
Right ventricular dysfunction 17.91 13.41 3 889413 1565 49714143
Bile duct stone 17.88 13.41 19 889397 3288 49712420
Cardiac dysfunction 17.85 13.41 4 889412 1697 49714011
Kyphosis 17.84 13.41 9 889407 2286 49713422
High density lipoprotein decreased 17.84 13.41 4 889412 1696 49714012
Angiopathy 17.83 13.41 28 889388 4094 49711614
Hypertensive emergency 17.83 13.41 3 889413 1560 49714148
Rheumatic fever 17.82 13.41 405 889011 16462 49699246
Weight bearing difficulty 17.79 13.41 84 889332 2220 49713488
Splenic infarction 17.78 13.41 3 889413 1557 49714151
Tooth fracture 17.78 13.41 253 889163 9398 49706310
Hypoaesthesia 17.77 13.41 2524 886892 124733 49590975
Mouth haemorrhage 17.73 13.41 53 889363 6143 49709565
Pulmonary sarcoidosis 17.70 13.41 44 889372 829 49714879
Paradoxical drug reaction 17.53 13.41 23 889393 3624 49712084
Incorrect dosage administered 17.49 13.41 68 889348 1646 49714062
Injection site streaking 17.49 13.41 10 889406 29 49715679
Varices oesophageal 17.48 13.41 14 889402 2775 49712933
Dyschezia 17.47 13.41 5 889411 1799 49713909
Gangrene 17.47 13.41 35 889381 4657 49711051
Renal artery stenosis 17.41 13.41 4 889412 1668 49714040
BK virus infection 17.39 13.41 15 889401 2866 49712842
Decreased interest 17.35 13.41 16 889400 2960 49712748
Stem cell transplant 17.35 13.41 4 889412 1664 49714044
Bite 17.34 13.41 27 889389 354 49715354
Prothrombin time shortened 17.33 13.41 4 889412 1663 49714045
Pulmonary mass 17.30 13.41 441 888975 18264 49697444
Eye inflammation 17.28 13.41 130 889286 4078 49711630
Discontinued product administered 17.25 13.41 10 889406 30 49715678
Mesenteritis 17.23 13.41 17 889399 134 49715574
Meningitis aseptic 17.21 13.41 29 889387 4123 49711585
Polyhydramnios 17.21 13.41 7 889409 2018 49713690
Red blood cell sedimentation rate 17.19 13.41 115 889301 3471 49712237
Pelvic inflammatory disease 17.19 13.41 3 889413 1519 49714189
Mean cell haemoglobin concentration decreased 17.12 13.41 15 889401 2844 49712864
Central venous catheterisation 17.09 13.41 8 889408 2122 49713586
Meniscus operation 17.09 13.41 15 889401 100 49715608
Polyp 17.08 13.41 46 889370 5516 49710192
Cutaneous T-cell lymphoma 17.08 13.41 55 889361 1209 49714499
Nasal polyps 17.06 13.41 12 889404 2542 49713166
Gastrointestinal stoma complication 17.00 13.41 3 889413 1507 49714201
Laryngeal disorder 16.96 13.41 44 889372 852 49714856
Tinea pedis 16.95 13.41 55 889361 1214 49714494
Cor pulmonale 16.91 13.41 6 889410 1881 49713827
Injection site hyperaesthesia 16.90 13.41 11 889405 43 49715665
Diabetic neuropathy 16.90 13.41 23 889393 3568 49712140
Hepatitis B virus test positive 16.88 13.41 20 889396 198 49715510
Dermatitis psoriasiform 16.86 13.41 67 889349 1639 49714069
Mood swings 16.85 13.41 189 889227 15765 49699943
Synovial disorder 16.83 13.41 44 889372 856 49714852
Device allergy 16.80 13.41 10 889406 32 49715676
Metastatic bronchial carcinoma 16.64 13.41 15 889401 104 49715604
Mole excision 16.61 13.41 16 889400 122 49715586
Rhonchi 16.55 13.41 10 889406 2297 49713411
Swelling of eyelid 16.52 13.41 6 889410 1854 49713854
Carbon dioxide decreased 16.48 13.41 6 889410 1851 49713857
Intracardiac thrombus 16.40 13.41 9 889407 2180 49713528
Bladder repair 16.35 13.41 13 889403 74 49715634
Pneumonia influenzal 16.33 13.41 3 889413 1464 49714244
Aphthous ulcer 16.29 13.41 114 889302 10483 49705225
Listless 16.27 13.41 11 889405 2379 49713329
Liver disorder 16.24 13.41 514 888902 36708 49679000
Spinal laminectomy 16.22 13.41 36 889380 628 49715080
Cellulitis 16.22 13.41 1049 888367 69749 49645959
Femur fracture 16.19 13.41 518 888898 36946 49678762
Quadriparesis 16.18 13.41 5 889411 1711 49713997
Blood creatinine decreased 16.17 13.41 40 889376 4936 49710772
Abdominal adhesions 16.15 13.41 15 889401 2765 49712943
Bacterial sepsis 16.14 13.41 24 889392 3588 49712120
Type IV hypersensitivity reaction 16.14 13.41 12 889404 2470 49713238
Extradural haematoma 16.13 13.41 4 889412 1583 49714125
Lower respiratory tract infection viral 16.11 13.41 36 889380 631 49715077
Psychogenic seizure 16.09 13.41 4 889412 1581 49714127
Pregnancy 16.09 13.41 396 889020 29181 49686527
Osteomyelitis 16.08 13.41 286 889130 22067 49693641
Ulcer 16.06 13.41 467 888949 19733 49695975
Catheterisation cardiac 16.04 13.41 29 889387 4011 49711697
Oesophageal ulcer 15.95 13.41 28 889388 3917 49711791
Intentional dose omission 15.93 13.41 147 889269 4903 49710805
Fatigue 15.89 13.41 13066 876350 694535 49021173
Dizziness postural 15.89 13.41 55 889361 6090 49709618
Red blood cell sedimentation rate decreased 15.88 13.41 17 889399 149 49715559
Influenza like illness 15.87 13.41 1194 888222 56265 49659443
Burning sensation 15.85 13.41 963 888453 44483 49671225
Anal haemorrhage 15.82 13.41 5 889411 1687 49714021
Peripheral motor neuropathy 15.77 13.41 3 889413 1428 49714280
Defaecation urgency 15.77 13.41 18 889398 3015 49712693
Facial paralysis 15.76 13.41 145 889271 12570 49703138
Multiple injuries 15.74 13.41 5 889411 1681 49714027
Acinetobacter infection 15.71 13.41 3 889413 1424 49714284
Bursa disorder 15.71 13.41 15 889401 113 49715595
Abdominal abscess 15.71 13.41 29 889387 3979 49711729
In vitro fertilisation 15.68 13.41 12 889404 64 49715644
Eructation 15.67 13.41 68 889348 7053 49708655
Intra-abdominal haematoma 15.67 13.41 4 889412 1553 49714155
Enteritis infectious 15.67 13.41 7 889409 1908 49713800
Ligament operation 15.65 13.41 8 889408 17 49715691
Coronavirus infection 15.64 13.41 17 889399 2912 49712796
Metastases to spine 15.60 13.41 16 889400 2815 49712893
Medical device discomfort 15.60 13.41 5 889411 1672 49714036
Needle issue 15.59 13.41 196 889220 7079 49708629
Emotional disorder 15.54 13.41 133 889283 11703 49704005
Anal fissure 15.53 13.41 19 889397 3086 49712622
Lymphadenopathy 15.52 13.41 729 888687 32770 49682938
Talipes 15.51 13.41 3 889413 1411 49714297
Apraxia 15.49 13.41 4 889412 1541 49714167
Craniocerebral injury 15.42 13.41 10 889406 2211 49713497
Mucosal disorder 15.39 13.41 7 889409 1888 49713820
Spinal fusion acquired 15.38 13.41 7 889409 10 49715698
False positive tuberculosis test 15.38 13.41 7 889409 10 49715698
Peripheral arterial occlusive disease 15.32 13.41 24 889392 3513 49712195
Infected bunion 15.29 13.41 5 889411 0 49715708
Smear cervix 15.29 13.41 5 889411 0 49715708
Trismus 15.20 13.41 22 889394 3326 49712382
Maternal exposure during breast feeding 15.15 13.41 21 889395 3233 49712475
Congenital anomaly 15.13 13.41 4 889412 1517 49714191
Device alarm issue 15.11 13.41 3 889413 1385 49714323
Exposure via skin contact 15.06 13.41 18 889398 180 49715528
Cerebral venous thrombosis 15.06 13.41 7 889409 1864 49713844
Liver abscess 15.05 13.41 14 889402 2579 49713129
Vascular pseudoaneurysm 15.05 13.41 3 889413 1381 49714327
Anticonvulsant drug level increased 15.05 13.41 3 889413 1381 49714327
Mean platelet volume decreased 15.04 13.41 63 889353 1579 49714129
Sputum increased 15.00 13.41 7 889409 1860 49713848
Nephrotic syndrome 14.99 13.41 39 889377 4731 49710977
Conjunctival hyperaemia 14.97 13.41 9 889407 2073 49713635
Bone sequestrum 14.95 13.41 3 889413 1375 49714333
Eyelid exfoliation 14.94 13.41 15 889401 121 49715587
Amyotrophic lateral sclerosis 14.94 13.41 47 889369 1020 49714688
Type I hypersensitivity 14.91 13.41 12 889404 2373 49713335
Asthmatic crisis 14.89 13.41 5 889411 1623 49714085
Product taste abnormal 14.88 13.41 6 889410 1739 49713969
Dyspareunia 14.87 13.41 10 889406 2169 49713539
Paresis 14.82 13.41 9 889407 2062 49713646
Lip ulceration 14.82 13.41 67 889349 1738 49713970
Hyporeflexia 14.81 13.41 6 889410 1734 49713974
Intentional underdose 14.80 13.41 5 889411 1617 49714091
Libido decreased 14.80 13.41 12 889404 2364 49713344
Alcoholism 14.78 13.41 5 889411 1615 49714093
Vitamin B12 deficiency 14.76 13.41 29 889387 3887 49711821
Premature rupture of membranes 14.74 13.41 37 889379 4543 49711165
Menstruation irregular 14.72 13.41 57 889359 6105 49709603
Mallory-Weiss syndrome 14.68 13.41 3 889413 1357 49714351
Enterocolitis haemorrhagic 14.63 13.41 3 889413 1354 49714354
Application site vesicles 14.60 13.41 3 889413 1352 49714356
Injection site scab 14.58 13.41 25 889391 357 49715351
Hyperparathyroidism secondary 14.52 13.41 3 889413 1347 49714361
Spinal meningioma benign 14.51 13.41 14 889402 107 49715601
Strabismus 14.49 13.41 7 889409 1823 49713885
Concomitant disease progression 14.48 13.41 9 889407 2036 49713672
Crystal urine present 14.43 13.41 4 889412 1470 49714238
Eye irritation 14.42 13.41 213 889203 16927 49698781
Staphylococcal sepsis 14.41 13.41 69 889347 6967 49708741
Localised oedema 14.39 13.41 41 889375 4826 49710882
Chorea 14.37 13.41 3 889413 1337 49714371
Hair colour changes 14.34 13.41 16 889400 2708 49713000
Cytomegalovirus colitis 14.32 13.41 8 889408 1919 49713789
Food allergy 14.32 13.41 84 889332 8053 49707655
Nephrogenic anaemia 14.32 13.41 6 889410 1699 49714009
Intervertebral disc compression 14.29 13.41 43 889373 910 49714798
Gingival injury 14.28 13.41 8 889408 22 49715686
Pelvic venous thrombosis 14.28 13.41 3 889413 1331 49714377
Suicidal behaviour 14.27 13.41 12 889404 2322 49713386
Musculoskeletal injury 14.22 13.41 14 889402 110 49715598
Nervous system disorder 14.21 13.41 200 889216 16023 49699685
Product use complaint 14.11 13.41 7 889409 1795 49713913
Mean cell haemoglobin increased 14.09 13.41 11 889405 2209 49713499
Peripheral vascular disorder 14.09 13.41 49 889367 5418 49710290
Therapy change 14.03 13.41 46 889370 5179 49710529
Expired product administered 14.03 13.41 48 889368 5334 49710374
Melkersson-Rosenthal syndrome 13.97 13.41 7 889409 14 49715694
Oral mucosal roughening 13.97 13.41 7 889409 14 49715694
Meningitis staphylococcal 13.97 13.41 7 889409 14 49715694
Blood urine present 13.96 13.41 151 889265 12682 49703026
Sternal fracture 13.92 13.41 9 889407 1993 49713715
Tonsillitis 13.90 13.41 140 889276 4783 49710925
Hypercoagulation 13.90 13.41 8 889408 1887 49713821
Vaginal operation 13.84 13.41 6 889410 7 49715701
Spinal disorder 13.75 13.41 213 889203 8057 49707651
Labelled drug-disease interaction medication error 13.72 13.41 15 889401 135 49715573
Product availability issue 13.70 13.41 10 889406 2078 49713630
Myoglobin blood increased 13.65 13.41 3 889413 1290 49714418
Jaw disorder 13.64 13.41 43 889373 4900 49710808
Blood urea decreased 13.61 13.41 11 889405 2171 49713537
Poor quality sleep 13.61 13.41 208 889208 16438 49699270
Toxoplasmosis 13.59 13.41 4 889412 1413 49714295
Mucosal erosion 13.56 13.41 3 889413 1284 49714424
Antibody test positive 13.51 13.41 78 889338 2233 49713475
Recurrent cancer 13.49 13.41 7 889409 1750 49713958
Metabolic surgery 13.49 13.41 44 889372 974 49714734
Vaginal discharge 13.48 13.41 47 889369 5193 49710515
Papilloma viral infection 13.46 13.41 52 889364 1255 49714453
Tendon disorder 13.45 13.41 148 889268 5174 49710534

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Injection site pain 11453.22 13.62 5373 220949 27073 29321132
Injection site erythema 7235.58 13.62 3031 223291 10925 29337280
Drug ineffective 4867.80 13.62 9348 216974 353822 28994383
Arthralgia 4851.62 13.62 5636 220686 133981 29214224
Injection site swelling 4478.53 13.62 1925 224397 7492 29340713
Injection site pruritus 3951.48 13.62 1538 224784 4311 29343894
Injection site reaction 3125.50 13.62 1583 224739 9605 29338600
Injection site bruising 2813.20 13.62 1303 225019 6277 29341928
Therapeutic product effect decreased 2680.03 13.62 2037 224285 27414 29320791
Injection site haemorrhage 2657.54 13.62 1293 225029 7093 29341112
Wrong technique in product usage process 2597.07 13.62 2053 224269 29375 29318830
Therapeutic product effect incomplete 2592.93 13.62 2253 224069 37052 29311153
Joint swelling 2587.54 13.62 2493 223829 47137 29301068
Nasopharyngitis 2470.30 13.62 2646 223676 57019 29291186
Pain in extremity 2171.67 13.62 3385 222937 107048 29241157
Pain 2140.13 13.62 4303 222019 167129 29181076
Product dose omission issue 2060.55 13.62 3072 223250 93311 29254894
Accidental exposure to product 2023.37 13.62 1171 225151 9582 29338623
Injection site warmth 1686.74 13.62 606 225716 1240 29346965
Musculoskeletal stiffness 1672.94 13.62 1731 224591 35727 29312478
Device issue 1556.55 13.62 882 225440 6898 29341307
Acute kidney injury 1484.08 13.62 155 226167 265112 29083093
Product storage error 1479.46 13.62 801 225521 5669 29342536
Injection site rash 1432.97 13.62 648 225674 2916 29345289
Mobility decreased 1292.87 13.62 1269 225053 24511 29323694
Therapeutic response decreased 1177.34 13.62 1183 225139 23528 29324677
Toxicity to various agents 1145.54 13.62 42 226280 173619 29174586
Drug interaction 1132.62 13.62 104 226218 197281 29150924
Sinusitis 1122.73 13.62 1349 224973 33001 29315204
Psoriasis 1120.04 13.62 1306 225016 30921 29317284
Joint stiffness 1038.68 13.62 734 225588 8739 29339466
Arthritis 992.07 13.62 1086 225236 23933 29324272
Hypotension 965.60 13.62 164 226158 194190 29154015
Underdose 946.32 13.62 760 225562 11109 29337096
Anaemia 870.79 13.62 232 226090 200719 29147486
Musculoskeletal pain 866.65 13.62 1088 225234 27865 29320340
Psoriatic arthropathy 834.60 13.62 775 225547 13916 29334289
Treatment failure 834 13.62 1210 225112 35729 29312476
Skin plaque 802.62 13.62 445 225877 3317 29344888
Death 797.35 13.62 869 225453 341215 29006990
Arthropathy 786.46 13.62 896 225426 20658 29327547
Injection site mass 758.98 13.62 490 225832 4965 29343240
Injection site discomfort 714.73 13.62 296 226026 1021 29347184
Febrile neutropenia 700.82 13.62 39 226283 112201 29236004
Swelling 678.93 13.62 1073 225249 34210 29313995
Knee arthroplasty 671.47 13.62 465 225857 5344 29342861
Injection site discolouration 669.80 13.62 282 226040 1025 29347180
Injection site urticaria 666.37 13.62 298 226024 1298 29346907
Synovitis 664.40 13.62 598 225724 10292 29337913
Completed suicide 593.78 13.62 22 226300 90224 29257981
Thrombocytopenia 592.29 13.62 151 226171 134672 29213533
Injection site induration 588.98 13.62 319 226003 2257 29345948
Drug abuse 569.43 13.62 8 226314 79875 29268330
Injection site extravasation 569.42 13.62 306 226016 2127 29346078
Diarrhoea 560.33 13.62 1062 225260 331636 29016569
Neutropenia 551.37 13.62 162 226160 131549 29216656
Confusional state 546.92 13.62 151 226171 127726 29220479
Malignant neoplasm progression 515.55 13.62 10 226312 73849 29274356
Influenza 511.74 13.62 1045 225277 40836 29307369
Contraindicated product administered 506.36 13.62 661 225661 17605 29330600
Peripheral swelling 499.51 13.62 1336 224986 62403 29285802
Dyspnoea 480.28 13.62 1126 225196 325606 29022599
Vomiting 479.12 13.62 552 225770 211708 29136497
Drug intolerance 461.63 13.62 1093 225229 47286 29300919
Dehydration 451.99 13.62 157 226165 114591 29233614
Surgery 445.42 13.62 499 225823 11280 29336925
Hyponatraemia 429.82 13.62 21 226301 67612 29280593
Hyperkalaemia 425.68 13.62 9 226313 61383 29286822
Rhabdomyolysis 421.29 13.62 9 226313 60799 29287406
Respiratory tract congestion 403.23 13.62 329 225993 4920 29343285
Bradycardia 402.73 13.62 25 226297 65604 29282601
Constipation 396.32 13.62 189 226133 113971 29234234
Therapy non-responder 381.89 13.62 775 225547 30136 29318069
Decreased appetite 374.18 13.62 337 225985 145005 29203200
Intentional product misuse 373.68 13.62 822 225500 33839 29314366
Respiratory failure 372.06 13.62 139 226183 96992 29251213
Gastrointestinal haemorrhage 368.96 13.62 79 226243 79454 29268751
Cardiac arrest 365.85 13.62 101 226221 85490 29262715
General physical health deterioration 355.90 13.62 171 226151 102686 29245519
Back pain 350.73 13.62 1631 224691 100653 29247552
Headache 349.73 13.62 2403 223919 171604 29176601
Injection site haematoma 349.05 13.62 189 226133 1336 29346869
Hip arthroplasty 345.75 13.62 262 226060 3496 29344709
Bone erosion 345.20 13.62 232 226090 2528 29345677
Blood creatinine increased 342.73 13.62 112 226210 84990 29263215
Overdose 337.77 13.62 96 226226 79723 29268482
Tachycardia 329.64 13.62 75 226247 72335 29275870
Condition aggravated 328.80 13.62 2078 224244 144217 29203988
Disease progression 322.57 13.62 112 226210 81804 29266401
Hypokalaemia 317.63 13.62 16 226306 50187 29298018
C-reactive protein abnormal 316.68 13.62 316 226006 6220 29341985
Haemoglobin decreased 314.26 13.62 223 226099 108152 29240053
Syncope 314.02 13.62 115 226207 81256 29266949
Seizure 312.81 13.62 161 226161 92962 29255243
Pancytopenia 306.96 13.62 126 226196 83042 29265163
Hypoglycaemia 300.88 13.62 17 226305 48329 29299876
Oropharyngeal pain 299.35 13.62 680 225642 28605 29319600
Apparent death 286.91 13.62 228 226094 3276 29344929
Cardio-respiratory arrest 285.96 13.62 28 226294 50573 29297632
Renal impairment 284.69 13.62 133 226189 81200 29267005
Platelet count decreased 283.49 13.62 231 226091 104441 29243764
Abdominal pain 281.81 13.62 374 225948 134983 29213222
International normalised ratio increased 278 13.62 15 226307 44357 29303848
Iritis 277.09 13.62 152 226170 1106 29347099
Pyrexia 271.70 13.62 1206 225116 286416 29061789
Disability 266.34 13.62 241 226081 4175 29344030
Neck pain 265.16 13.62 538 225784 20909 29327296
Atrial fibrillation 264.56 13.62 251 226071 105395 29242810
Unevaluable event 263.80 13.62 655 225667 29196 29319009
Hypoxia 260.57 13.62 29 226293 47350 29300855
Electrocardiogram QT prolonged 260.14 13.62 3 226319 36134 29312071
Incorrect dose administered by device 258.88 13.62 156 226166 1383 29346822
Agitation 257.01 13.62 42 226280 51262 29296943
Intentional overdose 254.62 13.62 9 226313 38519 29309686
Diverticulitis 250.36 13.62 470 225852 17234 29330971
Hand deformity 244.94 13.62 170 226152 1960 29346245
Neutrophil count decreased 243.85 13.62 25 226297 43542 29304663
Tuberculin test positive 242.85 13.62 132 226190 941 29347264
Metabolic acidosis 241.46 13.62 11 226311 37651 29310554
Infection 239.82 13.62 1192 225130 75559 29272646
Drug hypersensitivity 238.06 13.62 1096 225226 67310 29280895
Injection site vesicles 231.66 13.62 103 226219 441 29347764
Rhinorrhoea 230.33 13.62 509 225813 21010 29327195
Musculoskeletal disorder 229.61 13.62 240 226082 5000 29343205
Injection site irritation 225.35 13.62 125 226197 932 29347273
Hallucination 223.07 13.62 37 226285 44675 29303530
Delirium 219.48 13.62 23 226299 39374 29308831
Cardiac failure 218.34 13.62 172 226150 79115 29269090
Lactic acidosis 215.55 13.62 3 226319 30244 29317961
Multiple organ dysfunction syndrome 215.05 13.62 107 226215 63009 29285196
Fear of injection 213.81 13.62 111 226211 712 29347493
Grip strength decreased 212.58 13.62 161 226161 2146 29346059
Joint lock 209.38 13.62 122 226200 1010 29347195
Sepsis 208.47 13.62 492 225830 142190 29206015
Sinus congestion 207.05 13.62 214 226108 4398 29343807
Fall 206.92 13.62 681 225641 176497 29171708
Herpes zoster 206.61 13.62 601 225721 29451 29318754
Paranasal sinus hypersecretion 206.36 13.62 108 226214 706 29347499
Joint range of motion decreased 206.14 13.62 243 226079 5811 29342394
Foot deformity 205.44 13.62 200 226122 3815 29344390
Red blood cell sedimentation rate abnormal 204.02 13.62 157 226165 2146 29346059
Mental status changes 203.58 13.62 17 226305 34910 29313295
Suicide attempt 203.32 13.62 15 226307 34095 29314110
Blood pressure decreased 203.15 13.62 49 226273 45428 29302777
Melaena 200.20 13.62 9 226313 31167 29317038
Skin laceration 199.69 13.62 327 225995 10735 29337470
Rheumatoid arthritis 199.36 13.62 620 225702 31532 29316673
Foetal exposure during pregnancy 198.74 13.62 16 226306 33851 29314354
Nodule 197.41 13.62 219 226103 4893 29343312
Depressed level of consciousness 197.21 13.62 25 226297 36917 29311288
Somnolence 197.05 13.62 258 226064 93697 29254508
Coma 196.01 13.62 33 226289 39417 29308788
Finger deformity 195.49 13.62 117 226205 1023 29347182
Product use in unapproved indication 195.40 13.62 226 226096 86649 29261556
Septic shock 192.99 13.62 120 226202 62440 29285765
Feeling abnormal 192.10 13.62 876 225446 53569 29294636
Chondropathy 191.77 13.62 107 226215 808 29347397
Hypersensitivity 190.99 13.62 857 225465 52046 29296159
Injury associated with device 187.92 13.62 103 226219 748 29347457
Loss of personal independence in daily activities 185.80 13.62 520 225802 24920 29323285
Blood creatine phosphokinase increased 185.10 13.62 42 226280 40602 29307603
Cardiac failure congestive 184.65 13.62 188 226134 76393 29271812
Oxygen saturation decreased 184.62 13.62 57 226265 44880 29303325
Knee operation 182.33 13.62 123 226199 1349 29346856
Red blood cell sedimentation rate increased 182.30 13.62 254 226068 7207 29340998
Pneumonia aspiration 181.92 13.62 31 226291 36706 29311499
Loss of consciousness 181.76 13.62 179 226143 73877 29274328
Localised infection 180.86 13.62 355 225967 13461 29334744
Plasma cell myeloma 180.13 13.62 33 226289 37082 29311123
Inflammation 179.38 13.62 478 225844 22250 29325955
Aggression 178.20 13.62 29 226293 35512 29312693
Inappropriate schedule of product administration 177.03 13.62 742 225580 43730 29304475
Osteoarthritis 176.83 13.62 413 225909 17690 29330515
Hyperglycaemia 176.40 13.62 26 226296 34261 29313944
Uveitis 172.23 13.62 220 226102 5727 29342478
Mycobacterium tuberculosis complex test positive 171.92 13.62 104 226218 929 29347276
Injection site macule 171.00 13.62 47 226275 13 29348192
Impaired work ability 170.25 13.62 213 226109 5427 29342778
Acute myocardial infarction 169.74 13.62 79 226243 48359 29299846
Upper respiratory tract infection 169.19 13.62 527 225795 26822 29321383
Drug reaction with eosinophilia and systemic symptoms 167.72 13.62 12 226310 27980 29320225
Haematuria 167.48 13.62 64 226258 44075 29304130
Sarcoidosis 164.98 13.62 147 226175 2493 29345712
Limb discomfort 164.87 13.62 277 226045 9291 29338914
Sleep disorder due to general medical condition, insomnia type 163.60 13.62 109 226213 1169 29347036
Asthenia 162.99 13.62 973 225349 214277 29133928
Lymphoma 162.05 13.62 279 226043 9549 29338656
Spinal operation 162.05 13.62 140 226182 2274 29345931
Infusion related reaction 157.81 13.62 69 226253 43817 29304388
Respiratory distress 156.99 13.62 28 226294 32078 29316127
Unresponsive to stimuli 155.80 13.62 9 226313 25117 29323088
Spinal fusion surgery 155.71 13.62 91 226231 758 29347447
Blood bilirubin increased 154.38 13.62 35 226287 33858 29314347
Dysphagia 153.90 13.62 117 226205 54809 29293396
Therapeutic product effect delayed 150.99 13.62 98 226224 1002 29347203
Cerebral haemorrhage 150.24 13.62 29 226293 31397 29316808
Shoulder operation 149.39 13.62 88 226234 745 29347460
Urinary retention 149.23 13.62 31 226291 31867 29316338
Orthostatic hypotension 147.06 13.62 6 226316 22623 29325582
Nasal congestion 144.89 13.62 393 225929 18486 29329719
Skin haemorrhage 144.22 13.62 158 226164 3479 29344726
Injection site recall reaction 143.58 13.62 37 226285 0 29348205
Pleural effusion 142.14 13.62 206 226116 71702 29276503
Therapy cessation 141.31 13.62 330 225992 14132 29334073
Chronic kidney disease 139.49 13.62 52 226270 36364 29311841
Oedema 138.81 13.62 68 226254 40415 29307790
Ill-defined disorder 138.47 13.62 288 226034 11390 29336815
Weight decreased 137.66 13.62 640 225682 150265 29197940
Bone marrow failure 136.26 13.62 23 226299 27426 29320779
Ankylosing spondylitis 136.21 13.62 164 226158 4012 29344193
Prostate cancer 135.52 13.62 467 225855 25060 29323145
Impaired healing 135.36 13.62 312 226010 13246 29334959
Renal failure 134.75 13.62 461 225861 118138 29230067
Musculoskeletal discomfort 134.67 13.62 202 226120 6139 29342066
Haematemesis 133.06 13.62 16 226306 24610 29323595
Blood glucose increased 131.97 13.62 154 226168 58830 29289375
Coronary artery disease 131.84 13.62 88 226234 44102 29304103
Mucosal inflammation 131.72 13.62 39 226283 31556 29316649
Iridocyclitis 131.59 13.62 100 226222 1340 29346865
Joint noise 130.65 13.62 70 226252 483 29347722
Haemorrhage 130.16 13.62 93 226229 44979 29303226
Blood urea increased 130.11 13.62 28 226294 28084 29320121
Tooth infection 130.03 13.62 185 226137 5354 29342851
Arthropod bite 128.14 13.62 122 226200 2261 29345944
Hypoacusis 126.86 13.62 316 226006 14107 29334098
Joint destruction 126.45 13.62 56 226266 237 29347968
Encephalopathy 124.61 13.62 41 226281 31002 29317203
Haematocrit decreased 124.36 13.62 34 226288 28988 29319217
Neoplasm progression 124.18 13.62 4 226318 18608 29329597
Agranulocytosis 123.96 13.62 8 226314 20332 29327873
Nausea 123.65 13.62 1519 224803 287736 29060469
Drug dose omission by device 123.55 13.62 89 226233 1093 29347112
Mass 122.69 13.62 206 226116 6905 29341300
Drug level increased 122.02 13.62 5 226317 18782 29329423
Sneezing 121.12 13.62 159 226163 4255 29343950
Pulmonary oedema 121.04 13.62 90 226232 42645 29305560
Bronchitis 120.30 13.62 580 225742 36288 29311917
Hypervolaemia 119.90 13.62 3 226319 17542 29330663
Adverse event 119.03 13.62 320 226002 14971 29333234
Decreased immune responsiveness 118.59 13.62 94 226228 1345 29346860
Device malfunction 117.96 13.62 224 226098 8283 29339922
Pharyngitis streptococcal 117.37 13.62 109 226213 1955 29346250
Cholestasis 115.71 13.62 20 226302 23442 29324763
Abnormal behaviour 115.64 13.62 19 226303 23108 29325097
Joint effusion 115.25 13.62 151 226171 4033 29344172
Hepatic failure 114.14 13.62 49 226273 31463 29316742
Toxic epidermal necrolysis 114.10 13.62 6 226316 18147 29330058
Blood pressure increased 113.73 13.62 247 226075 73556 29274649
Dysarthria 113.68 13.62 47 226275 30864 29317341
Sinus disorder 112.87 13.62 180 226142 5775 29342430
Gait disturbance 112.05 13.62 951 225371 72398 29275807
Ear infection 111.96 13.62 213 226109 7887 29340318
Ascites 111.85 13.62 71 226251 36548 29311657
Sedation 111.82 13.62 5 226317 17400 29330805
Skin exfoliation 111.37 13.62 404 225918 22241 29325964
Furuncle 111.22 13.62 125 226197 2834 29345371
Respiratory arrest 111.19 13.62 30 226292 25803 29322402
Neuropathy peripheral 110.86 13.62 236 226086 70791 29277414
Adverse reaction 110.81 13.62 121 226201 2654 29345551
Extra dose administered 110.59 13.62 127 226195 2950 29345255
Leukopenia 110.20 13.62 157 226165 55046 29293159
Drug withdrawal syndrome 109.81 13.62 7 226315 17977 29330228
Blood alkaline phosphatase increased 109.74 13.62 40 226282 28366 29319839
Lymphocyte count decreased 107.96 13.62 11 226311 19260 29328945
Hypocalcaemia 107.86 13.62 15 226307 20650 29327555
Shoulder arthroplasty 107.26 13.62 57 226265 386 29347819
Injection site injury 107.19 13.62 45 226277 162 29348043
Rash maculo-papular 106.84 13.62 27 226295 24262 29323943
Erythema 106.53 13.62 963 225359 74643 29273562
Upper gastrointestinal haemorrhage 105.22 13.62 20 226302 21894 29326311
Cardiogenic shock 104.84 13.62 12 226310 19178 29329027
Demyelination 104.72 13.62 115 226207 2539 29345666
Tooth fracture 104.67 13.62 125 226197 3031 29345174
Hypoaesthesia 104.34 13.62 734 225588 52733 29295472
Shock 103.91 13.62 19 226303 21385 29326820
Suicidal ideation 103.73 13.62 69 226253 34647 29313558
Psychotic disorder 103.39 13.62 16 226306 20338 29327867
Heart rate increased 102.74 13.62 88 226234 38850 29309355
Anaphylactic reaction 101.27 13.62 42 226280 27531 29320674
Foot operation 100.91 13.62 62 226260 571 29347634
Cough 99.94 13.62 1441 224881 125286 29222919
Synovial cyst 99.88 13.62 96 226226 1801 29346404
Sinus headache 99.58 13.62 71 226251 857 29347348
White blood cell count decreased 99.47 13.62 317 226005 83045 29265160
Jaundice 99.23 13.62 50 226272 29246 29318959
Scratch 99.07 13.62 113 226209 2605 29345600
Disorientation 99.04 13.62 51 226271 29464 29318741
Device difficult to use 98.48 13.62 88 226234 1498 29346707
Dyspnoea exertional 98.08 13.62 81 226241 36409 29311796
Chest pain 97.30 13.62 483 225839 111490 29236715
Eosinophilia 96.77 13.62 25 226297 22136 29326069
Diabetic ketoacidosis 95.97 13.62 7 226315 16066 29332139
Palmar-plantar erythrodysaesthesia syndrome 95.61 13.62 4 226318 14755 29333450
Contusion 94.90 13.62 480 225842 30615 29317590
Rheumatoid factor negative 94.86 13.62 66 226256 764 29347441
Pancreatitis acute 94.77 13.62 34 226288 24351 29323854
Joint arthroplasty 94.69 13.62 61 226261 615 29347590
Circulatory collapse 94.12 13.62 15 226307 18658 29329547
Ventricular tachycardia 93.85 13.62 28 226294 22546 29325659
Bone cyst 93.59 13.62 57 226265 516 29347689
Drug-induced liver injury 93.48 13.62 25 226297 21630 29326575
Heart rate decreased 93.03 13.62 37 226285 24875 29323330
Therapy interrupted 92.70 13.62 201 226121 8185 29340020
Injection site papule 92.62 13.62 46 226276 265 29347940
Tumour lysis syndrome 92.57 13.62 3 226319 13881 29334324
Pneumonia 92.04 13.62 1813 224509 318359 29029846
Pneumonitis 91.83 13.62 50 226272 27994 29320211
Influenza like illness 91.71 13.62 401 225921 24069 29324136
Urticaria 91.69 13.62 724 225598 53936 29294269
Altered state of consciousness 91.65 13.62 20 226302 19869 29328336
Tubulointerstitial nephritis 91.62 13.62 13 226309 17630 29330575
Gamma-glutamyltransferase increased 91.51 13.62 45 226277 26692 29321513
Dyskinesia 90.78 13.62 21 226301 20040 29328165
Angioedema 90.64 13.62 67 226255 31848 29316357
Dizziness 90.27 13.62 972 225350 188712 29159493
Tuberculosis 89.48 13.62 181 226141 7015 29341190
Injection site inflammation 89.08 13.62 59 226263 626 29347579
Subdural haematoma 88.64 13.62 16 226306 18177 29330028
Haemoptysis 88.24 13.62 63 226259 30487 29317718
Acute respiratory failure 88.03 13.62 46 226276 26356 29321849
Arrhythmia 87.31 13.62 67 226255 31246 29316959
Onychoclasis 87.21 13.62 86 226236 1667 29346538
Tachypnoea 86.32 13.62 8 226314 15107 29333098
Aspartate aminotransferase increased 86.23 13.62 207 226115 59518 29288687
Sinus tachycardia 86.00 13.62 8 226314 15061 29333144
Restlessness 85.85 13.62 31 226291 22114 29326091
Hallucination, visual 85.61 13.62 8 226314 15007 29333198
Wheezing 85.43 13.62 77 226245 33163 29315042
Blood lactate dehydrogenase increased 85.17 13.62 21 226301 19188 29329017
Generalised tonic-clonic seizure 84.71 13.62 21 226301 19118 29329087
Nail disorder 84.34 13.62 86 226236 1738 29346467
Malaise 83.33 13.62 1698 224624 157904 29190301
Renal tubular necrosis 83.32 13.62 7 226315 14308 29333897
Nerve compression 83.29 13.62 104 226218 2644 29345561
Sensitivity to weather change 82.74 13.62 76 226246 1343 29346862
Joint warmth 82.30 13.62 41 226281 238 29347967
Myoclonus 81.80 13.62 5 226317 13304 29334901
Osteonecrosis of jaw 81.57 13.62 14 226308 16496 29331709
Acute respiratory distress syndrome 80.95 13.62 37 226285 22898 29325307
Exostosis 80.05 13.62 117 226205 3472 29344733
Hyperbilirubinaemia 79.95 13.62 10 226312 14924 29333281
Abdominal distension 79.89 13.62 143 226179 45768 29302437
Pulmonary hypertension 79.35 13.62 22 226300 18586 29329619
Cerebral infarction 79.34 13.62 45 226277 24630 29323575
Anti-cyclic citrullinated peptide antibody positive 79.24 13.62 59 226263 765 29347440
Dislocation of vertebra 79.13 13.62 45 226277 354 29347851
Cognitive disorder 78.26 13.62 41 226281 23458 29324747
Intervertebral disc space narrowing 78.25 13.62 57 226265 713 29347492
Leukocytosis 77.97 13.62 32 226290 21110 29327095
Acne cystic 77.50 13.62 48 226274 449 29347756
Haemorrhage intracranial 77.21 13.62 10 226312 14532 29333673
Rheumatoid nodule 76.96 13.62 88 226234 2034 29346171
Joint ankylosis 76.88 13.62 45 226277 376 29347829
Coagulopathy 74.82 13.62 22 226300 17885 29330320
Tenderness 74.75 13.62 147 226175 5580 29342625
Urinary tract infection 74.37 13.62 293 226029 72061 29276144
Enthesopathy 73.51 13.62 115 226207 3628 29344577
Urinary incontinence 73.10 13.62 18 226304 16463 29331742
Intentional self-injury 72.78 13.62 6 226316 12455 29335750
Injection site paraesthesia 72.75 13.62 30 226292 102 29348103
Circumstance or information capable of leading to medication error 72.56 13.62 73 226249 1451 29346754
Alanine aminotransferase increased 71.83 13.62 289 226033 70655 29277550
Ileus 71.62 13.62 12 226310 14390 29333815
Atlantoaxial instability 71.37 13.62 40 226282 305 29347900
Device use error 70.30 13.62 84 226238 2038 29346167
Limb operation 69.98 13.62 48 226274 542 29347663
Tremor 69.86 13.62 307 226015 73231 29274974
Spinal pain 69.82 13.62 130 226192 4734 29343471
Joint fluid drainage 69.72 13.62 27 226295 74 29348131
Chondrolysis 69.53 13.62 28 226294 88 29348117
Small intestinal obstruction 69.30 13.62 9 226313 13052 29335153
Accidental overdose 69.27 13.62 24 226298 17569 29330636
Spinal instability 69.26 13.62 40 226282 325 29347880
Rectal haemorrhage 69.19 13.62 98 226224 34451 29313754
Immune system disorder 69.13 13.62 121 226201 4196 29344009
Ventricular fibrillation 68.87 13.62 18 226304 15815 29332390
Therapeutic response delayed 68.83 13.62 43 226279 409 29347796
Drug eruption 68.66 13.62 282 226040 16459 29331746
Mineral metabolism disorder 68.56 13.62 40 226282 332 29347873
Pruritus 68.33 13.62 1265 225057 115584 29232621
Latent tuberculosis 68.23 13.62 60 226262 999 29347206
Full blood count decreased 68.01 13.62 19 226303 15973 29332232
Disseminated intravascular coagulation 67.81 13.62 34 226288 19946 29328259
Epilepsy 67.81 13.62 28 226294 18404 29329801
Wrist deformity 67.52 13.62 39 226283 317 29347888
Upper respiratory tract congestion 67.07 13.62 51 226271 684 29347521
Nephropathy toxic 66.23 13.62 4 226318 10752 29337453
Rotator cuff repair 65.84 13.62 36 226286 260 29347945
Stevens-Johnson syndrome 65.83 13.62 22 226300 16475 29331730
Neutrophil count increased 65.59 13.62 16 226306 14726 29333479
Joint injury 65.33 13.62 156 226166 6777 29341428
Pancreatitis 65.13 13.62 102 226220 34412 29313793
Corrective lens user 65.00 13.62 23 226299 44 29348161
Medication error 64.94 13.62 41 226281 21170 29327035
Neutropenic sepsis 64.90 13.62 7 226315 11720 29336485
Treatment noncompliance 64.83 13.62 54 226268 24173 29324032
Hepatic encephalopathy 64.52 13.62 11 226311 13024 29335181
Hypophagia 64.37 13.62 40 226282 20832 29327373
Cyanosis 64.25 13.62 6 226316 11261 29336944
Blood sodium decreased 63.82 13.62 17 226305 14750 29333455
Fluid retention 63.68 13.62 52 226270 23508 29324697
Myelosuppression 63.51 13.62 9 226313 12218 29335987
Haematoma 63.03 13.62 51 226271 23161 29325044
Throat irritation 62.57 13.62 178 226144 8607 29339598
Alanine aminotransferase abnormal 62.50 13.62 94 226228 2863 29345342
Hepatocellular injury 62.41 13.62 43 226279 21200 29327005
Tooth disorder 62.05 13.62 187 226135 9342 29338863
Cytomegalovirus infection 61.80 13.62 52 226270 23163 29325042
Skin fissures 61.67 13.62 109 226213 3810 29344395
Clostridium difficile colitis 61.46 13.62 13 226309 13199 29335006
Delusion 61.30 13.62 7 226315 11209 29336996
Hepatotoxicity 61.25 13.62 30 226292 17837 29330368
Skin discolouration 61.19 13.62 257 226065 15152 29333053
Pallor 61.18 13.62 43 226279 20981 29327224
Skin disorder 61.17 13.62 212 226110 11406 29336799
Intervertebral disc protrusion 61.10 13.62 175 226147 8495 29339710
Blood potassium decreased 61.03 13.62 22 226300 15712 29332493
Red blood cell count decreased 60.36 13.62 64 226258 25538 29322667
Tooth extraction 60.08 13.62 111 226211 4018 29344187
Atrial flutter 60.04 13.62 16 226306 13878 29334327
White blood cell count increased 59.90 13.62 123 226199 37393 29310812
Endodontic procedure 59.37 13.62 36 226286 323 29347882
Renal injury 59.34 13.62 5 226317 10197 29338008
Tenosynovitis 58.96 13.62 104 226218 3629 29344576
Angina pectoris 58.80 13.62 76 226246 27774 29320431
Oral surgery 58.35 13.62 42 226280 515 29347690
Malignant melanoma 57.89 13.62 152 226170 7009 29341196
Insurance issue 57.82 13.62 52 226270 893 29347312
Intentional product use issue 57.67 13.62 152 226170 42346 29305859
Aphasia 57.56 13.62 38 226284 19160 29329045
Speech disorder 57.46 13.62 57 226265 23459 29324746
Anuria 57.41 13.62 4 226318 9537 29338668
Increased tendency to bruise 57.25 13.62 100 226222 3462 29344743
Atelectasis 57.24 13.62 23 226299 15369 29332836
Brain oedema 56.89 13.62 12 226310 12208 29335997
Intestinal obstruction 56.66 13.62 39 226283 19238 29328967
Myocardial ischaemia 56.34 13.62 26 226296 16002 29332203
Palpitations 56.31 13.62 102 226220 32502 29315703
Ischaemic stroke 56.04 13.62 26 226296 15951 29332254
Cerebrovascular accident 55.74 13.62 352 225970 76559 29271646
Alopecia 55.71 13.62 291 226031 18793 29329412
Troponin increased 54.82 13.62 4 226318 9179 29339026
Electrolyte imbalance 54.74 13.62 10 226312 11264 29336941
Prostate infection 54.69 13.62 46 226276 719 29347486
Antibiotic therapy 54.68 13.62 20 226302 44 29348161
Blood potassium increased 54.31 13.62 22 226300 14629 29333576
Sudden death 54.27 13.62 20 226302 14090 29334115
Rheumatoid factor increased 54.15 13.62 40 226282 512 29347693
Muscle rigidity 53.69 13.62 5 226317 9406 29338799
Adrenal insufficiency 53.66 13.62 10 226312 11104 29337101
Acute coronary syndrome 53.63 13.62 14 226308 12311 29335894
Hypertension 53.61 13.62 602 225720 116012 29232193
Flushing 53.46 13.62 87 226235 28905 29319300
Anxiety 53.35 13.62 408 225914 84957 29263248
Feeling hot 52.93 13.62 247 226075 15241 29332964
Skin ulcer 52.76 13.62 284 226038 18556 29329649
Lyme disease 52.60 13.62 46 226276 760 29347445
Drug tolerance decreased 52.55 13.62 58 226264 1288 29346917
Hypothermia 52.47 13.62 5 226317 9234 29338971
Face oedema 52.41 13.62 8 226314 10275 29337930
Vein rupture 52.30 13.62 43 226279 650 29347555
Rheumatoid factor positive 52.13 13.62 42 226280 616 29347589
Skin mass 51.92 13.62 94 226228 3349 29344856
Nephrolithiasis 51.87 13.62 352 225970 24982 29323223
Cardiac operation 51.78 13.62 81 226241 2555 29345650
Prescribed overdose 51.22 13.62 4 226318 8679 29339526
Blood pressure systolic increased 50.96 13.62 33 226289 16812 29331393
Glomerular filtration rate decreased 50.56 13.62 12 226310 11254 29336951
Cardiomegaly 50.56 13.62 21 226301 13755 29334450
Rash papular 50.45 13.62 155 226167 7826 29340379
Rotator cuff syndrome 50.29 13.62 115 226207 4855 29343350
Acne 50.07 13.62 170 226152 9050 29339155
Pathogen resistance 50.03 13.62 3 226319 8113 29340092
Hallucination, auditory 49.97 13.62 7 226315 9586 29338619
Urine output decreased 49.90 13.62 6 226316 9232 29338973
Haemodynamic instability 49.71 13.62 3 226319 8070 29340135
Presyncope 49.39 13.62 31 226291 16058 29332147
Physical disability 48.89 13.62 54 226268 1200 29347005
Myocarditis 48.53 13.62 12 226310 10944 29337261
Back disorder 48.50 13.62 127 226195 5846 29342359
Malnutrition 48.43 13.62 12 226310 10929 29337276
Venous injury 48.13 13.62 29 226293 257 29347948
Haemodialysis 47.96 13.62 9 226313 9945 29338260
Anaphylactic shock 47.87 13.62 21 226301 13315 29334890
Bronchospasm 47.80 13.62 8 226314 9601 29338604
Blood pressure fluctuation 47.72 13.62 49 226273 19845 29328360
Neck surgery 47.35 13.62 31 226291 322 29347883
Transplant rejection 47.34 13.62 7 226315 9205 29339000
Irritability 47.23 13.62 60 226262 22092 29326113
Obstructive airways disorder 47.01 13.62 13 226309 11003 29337202
Ataxia 46.81 13.62 17 226305 12086 29336119
Meniscus injury 46.80 13.62 65 226257 1838 29346367
No adverse event 46.71 13.62 39 226283 17439 29330766
Drug specific antibody present 46.61 13.62 76 226246 2485 29345720
Scab 46.61 13.62 97 226225 3837 29344368
Fibromyalgia 46.47 13.62 77 226245 2552 29345653
Thrombotic microangiopathy 46.01 13.62 6 226316 8675 29339530
Rash pruritic 45.95 13.62 311 226011 22052 29326153
Hypercalcaemia 45.94 13.62 20 226302 12739 29335466
Mania 45.89 13.62 6 226316 8657 29339548
Pulmonary thrombosis 45.77 13.62 132 226190 6433 29341772
Balance disorder 45.63 13.62 134 226188 36036 29312169
Product quality issue 45.61 13.62 33 226289 15862 29332343
Right ventricular failure 45.53 13.62 4 226318 7886 29340319
Shock haemorrhagic 45.25 13.62 9 226313 9542 29338663
Cytopenia 45.25 13.62 10 226312 9849 29338356
Tooth loss 45.19 13.62 92 226230 3582 29344623
Post procedural infection 45.11 13.62 101 226221 4204 29344001
Pustular psoriasis 44.81 13.62 57 226265 1477 29346728
Cyst 44.73 13.62 96 226226 3881 29344324
Prothrombin time prolonged 44.72 13.62 7 226315 8825 29339380
Mitral valve incompetence 44.54 13.62 23 226299 13270 29334935
Burning sensation 44.45 13.62 240 226082 15698 29332507
Gastric disorder 44.44 13.62 181 226141 10523 29337682
Electrocardiogram abnormal 44.26 13.62 3 226319 7319 29340886
Tooth abscess 44.23 13.62 110 226212 4904 29343301
Tricuspid valve incompetence 44.02 13.62 6 226316 8388 29339817
Myopathy 43.90 13.62 13 226309 10520 29337685
Atrioventricular block complete 43.78 13.62 5 226317 8006 29340199
Emotional distress 43.73 13.62 26 226296 13869 29334336
Lipase increased 43.62 13.62 6 226316 8331 29339874
Ankle deformity 43.51 13.62 25 226297 201 29348004
Dental implantation 43.28 13.62 17 226305 49 29348156
Hypothyroidism 43.12 13.62 35 226287 15871 29332334
Lymphopenia 43.04 13.62 25 226297 13508 29334697
Eye operation 43.00 13.62 28 226294 288 29347917
Bacteraemia 42.91 13.62 37 226285 16286 29331919
Transaminases increased 42.73 13.62 67 226255 22595 29325610
Nightmare 42.55 13.62 17 226305 11400 29336805
Device failure 42.49 13.62 64 226258 1952 29346253
Toe operation 42.47 13.62 14 226308 19 29348186
Oesophagitis 42.44 13.62 19 226303 11904 29336301
Terminal state 42.39 13.62 87 226235 3407 29344798
Pulmonary arterial hypertension 42.38 13.62 4 226318 7445 29340760
Oliguria 42.12 13.62 4 226318 7408 29340797
Neoplasm malignant 42.00 13.62 247 226075 16678 29331527
Injection site nodule 41.96 13.62 54 226268 1416 29346789
Activated partial thromboplastin time prolonged 41.89 13.62 5 226317 7737 29340468
Respiratory rate increased 41.69 13.62 8 226314 8700 29339505
Incorrect disposal of product 41.68 13.62 27 226295 275 29347930
Cytology abnormal 41.54 13.62 30 226292 370 29347835
Paranasal sinus discomfort 41.44 13.62 38 226284 670 29347535
Nail pitting 41.25 13.62 24 226298 198 29348007
Body temperature decreased 41.21 13.62 15 226307 10649 29337556
Chills 41.21 13.62 348 225974 70952 29277253
Duodenal ulcer 41.15 13.62 10 226312 9228 29338977
Purpura 41.11 13.62 10 226312 9222 29338983
Left ventricular dysfunction 40.91 13.62 9 226313 8893 29339312
Elbow operation 40.87 13.62 20 226302 111 29348094
Blood calcium decreased 40.78 13.62 10 226312 9172 29339033
Clostridium difficile infection 40.74 13.62 38 226284 16103 29332102
Hip surgery 40.67 13.62 41 226281 817 29347388
Hernia repair 40.65 13.62 46 226276 1051 29347154
Anhedonia 40.61 13.62 4 226318 7196 29341009
Hepatitis 40.58 13.62 60 226262 20723 29327482
Haematochezia 40.42 13.62 146 226176 36837 29311368
Substance abuse 40.39 13.62 3 226319 6784 29341421
Spondylitis 40.32 13.62 45 226277 1012 29347193
COVID-19 40.14 13.62 141 226181 35873 29312332
Proteinuria 40.14 13.62 37 226285 15767 29332438
Urosepsis 40.05 13.62 16 226306 10730 29337475
Macule 40.04 13.62 44 226278 972 29347233
Transient ischaemic attack 40.00 13.62 73 226249 23197 29325008
Aspiration 39.88 13.62 14 226308 10166 29338039
Prescribed underdose 39.82 13.62 6 226316 7780 29340425
Rash erythematous 39.71 13.62 292 226030 21270 29326935
Sacroiliitis 39.63 13.62 46 226276 1081 29347124
Discomfort 39.62 13.62 220 226102 14543 29333662
Liver injury 39.58 13.62 24 226298 12666 29335539
Device related infection 39.24 13.62 37 226285 15599 29332606
Angina unstable 39.17 13.62 17 226305 10848 29337357
Rash macular 39.17 13.62 171 226151 10254 29337951
Failure to thrive 39.11 13.62 6 226316 7678 29340527
Hypoalbuminaemia 38.98 13.62 15 226307 10290 29337915
Exposure during pregnancy 38.61 13.62 9 226313 8545 29339660
Hepatitis cholestatic 38.44 13.62 4 226318 6889 29341316
Hyperuricaemia 38.41 13.62 4 226318 6885 29341320
Full blood count abnormal 38.30 13.62 35 226287 14978 29333227
Muscle spasms 38.13 13.62 705 225617 64377 29283828
Osteosclerosis 37.94 13.62 45 226277 1083 29347122
Arthrodesis 37.92 13.62 30 226292 428 29347777
Viral upper respiratory tract infection 37.92 13.62 69 226253 2468 29345737
Arthropod sting 37.80 13.62 26 226296 295 29347910
Chronic obstructive pulmonary disease 37.65 13.62 173 226149 40782 29307423
Pulmonary haemorrhage 37.62 13.62 12 226310 9258 29338947
Ankle operation 37.60 13.62 23 226299 210 29347995
Gastritis 37.47 13.62 57 226265 19460 29328745
Toxic skin eruption 37.24 13.62 14 226308 9743 29338462
Myelodysplastic syndrome 37.11 13.62 49 226273 17745 29330460
Acute myeloid leukaemia 37.03 13.62 43 226279 16470 29331735
Eye disorder 37.02 13.62 138 226184 7696 29340509
Subarachnoid haemorrhage 36.84 13.62 14 226308 9678 29338527
Klebsiella infection 36.82 13.62 6 226316 7343 29340862
Dental operation 36.72 13.62 27 226295 343 29347862
Gastroenteritis viral 36.39 13.62 112 226210 5660 29342545
Paranoia 36.34 13.62 15 226307 9862 29338343
Pulmonary sarcoidosis 36.26 13.62 31 226291 496 29347709
Pericardial effusion 36.04 13.62 67 226255 21141 29327064
Staphylococcal infection 35.95 13.62 362 225960 28878 29319327
Hepatic enzyme increased 35.75 13.62 406 225916 33393 29314812
Nail psoriasis 35.52 13.62 15 226307 55 29348150
Cardiac failure chronic 35.43 13.62 4 226318 6463 29341742
Hypovolaemic shock 35.25 13.62 3 226319 6069 29342136
Basal cell carcinoma 35.24 13.62 236 226086 16674 29331531
Hyperthermia 35.21 13.62 14 226308 9416 29338789
Hyperthyroidism 35.19 13.62 11 226311 8597 29339608
Product prescribing error 34.99 13.62 52 226270 17924 29330281
Bundle branch block right 34.76 13.62 5 226317 6712 29341493
Polyuria 34.75 13.62 7 226315 7355 29340850
Second primary malignancy 34.67 13.62 5 226317 6700 29341505
Injection site coldness 34.66 13.62 11 226311 12 29348193
Gallbladder operation 34.60 13.62 29 226293 451 29347754
Intestinal ischaemia 34.58 13.62 5 226317 6687 29341518
Gastric haemorrhage 34.39 13.62 14 226308 9283 29338922
Injection site hypoaesthesia 34.33 13.62 15 226307 61 29348144
Toothache 34.32 13.62 108 226214 5524 29342681
Parkinsonism 34.18 13.62 7 226315 7271 29340934
COVID-19 pneumonia 34.17 13.62 15 226307 9507 29338698
Meniscus operation 34.15 13.62 10 226312 6 29348199
Progressive multifocal leukoencephalopathy 34.14 13.62 12 226310 8707 29339498
Withdrawal syndrome 33.99 13.62 21 226301 10971 29337234
Myocardial infarction 33.83 13.62 617 225705 109679 29238526
Haemorrhagic stroke 33.71 13.62 3 226319 5853 29342352
Bronchopulmonary aspergillosis 33.66 13.62 27 226295 12317 29335888
Intestinal polyp 33.45 13.62 38 226284 872 29347333
Arteriosclerosis coronary artery 33.15 13.62 20 226302 10585 29337620
Coordination abnormal 33.09 13.62 7 226315 7107 29341098
Apnoea 32.87 13.62 4 226318 6098 29342107
Rheumatoid lung 32.80 13.62 26 226296 372 29347833
End stage renal disease 32.79 13.62 9 226313 7655 29340550
Injection site hypersensitivity 32.78 13.62 22 226300 239 29347966
Neck mass 32.62 13.62 48 226274 1433 29346772
Hyperlipidaemia 32.54 13.62 29 226293 12561 29335644
Nail bed disorder 32.45 13.62 10 226312 9 29348196
Oral herpes 32.44 13.62 92 226230 4440 29343765
Polyarthritis 32.16 13.62 84 226238 3861 29344344
Product use issue 32.06 13.62 246 226076 51198 29297007
Cataract operation 31.89 13.62 41 226281 1074 29347131
Pseudomonas infection 31.83 13.62 22 226300 10830 29337375
Acute generalised exanthematous pustulosis 31.76 13.62 3 226319 5580 29342625
Hiccups 31.68 13.62 14 226308 8839 29339366
Gait inability 31.67 13.62 245 226077 18130 29330075
Ventricular extrasystoles 31.65 13.62 21 226301 10561 29337644
Oedema peripheral 31.54 13.62 580 225742 102977 29245228
Hypogammaglobulinaemia 31.51 13.62 4 226318 5903 29342302
Hemiparesis 31.13 13.62 39 226283 14447 29333758
Ear congestion 31.08 13.62 27 226295 442 29347763
Atrial septal defect 30.93 13.62 7 226315 6782 29341423
Lupus-like syndrome 30.66 13.62 59 226263 2203 29346002
Blood pressure diastolic decreased 30.50 13.62 8 226314 7014 29341191
Peritonitis bacterial 30.46 13.62 4 226318 5752 29342453
Viral infection 30.45 13.62 206 226116 14604 29333601
Gastritis erosive 30.41 13.62 3 226319 5390 29342815
Lethargy 30.40 13.62 166 226156 37414 29310791
Disturbance in attention 30.31 13.62 75 226247 21349 29326856
Blood loss anaemia 30.22 13.62 9 226313 7257 29340948
Skin injury 30.08 13.62 40 226282 1084 29347121
Carpal tunnel syndrome 29.92 13.62 84 226238 4030 29344175
Low birth weight baby 29.73 13.62 7 226315 6601 29341604
Lung neoplasm malignant 29.69 13.62 200 226122 14157 29334048
Candida infection 29.68 13.62 44 226278 15181 29333024
Ingrown hair 29.67 13.62 16 226306 112 29348093
Artificial crown procedure 29.37 13.62 10 226312 16 29348189
Arthritis infective 29.30 13.62 66 226256 2758 29345447
Drug dependence 29.26 13.62 74 226248 20907 29327298
Rubber sensitivity 29.10 13.62 16 226306 117 29348088
Peritonitis 28.74 13.62 43 226279 14781 29333424
Pemphigoid 28.73 13.62 11 226311 7570 29340635
Transfusion 28.65 13.62 10 226312 7288 29340917
Hepatic enzyme abnormal 28.60 13.62 57 226265 2185 29346020
Petechiae 28.47 13.62 15 226307 8556 29339649
Carpal tunnel decompression 28.46 13.62 17 226305 148 29348057
Left ventricular hypertrophy 28.43 13.62 8 226314 6695 29341510
Rales 28.29 13.62 11 226311 7499 29340706
Gastroenteritis 28.13 13.62 33 226289 12583 29335622
Pulmonary fibrosis 28.11 13.62 210 226112 15372 29332833
Paraesthesia 28.05 13.62 573 225749 53272 29294933
Hydronephrosis 27.95 13.62 16 226306 8714 29339491
Psychomotor hyperactivity 27.83 13.62 14 226308 8199 29340006
Rocky mountain spotted fever 27.82 13.62 9 226313 11 29348194
Depression 27.47 13.62 472 225850 84675 29263530
Heart rate irregular 27.47 13.62 36 226286 13081 29335124
Prostatic operation 27.46 13.62 22 226300 320 29347885
Stress 27.36 13.62 268 226054 21222 29326983
Arthritis bacterial 27.24 13.62 85 226237 4328 29343877
Nocturia 27.24 13.62 15 226307 8347 29339858
Limb deformity 27.21 13.62 26 226296 484 29347721
Trigger finger 27.18 13.62 30 226292 666 29347539
Head injury 27.15 13.62 51 226271 16030 29332175
Ependymoma malignant 26.98 13.62 9 226313 13 29348192
Limb injury 26.85 13.62 142 226180 9213 29338992
Cholangitis 26.84 13.62 12 226310 7525 29340680
Secretion discharge 26.83 13.62 82 226240 4128 29344077
Memory impairment 26.82 13.62 410 225912 36060 29312145
Dermatitis contact 26.77 13.62 66 226256 2926 29345279
Limb crushing injury 26.73 13.62 13 226309 71 29348134
Systemic lupus erythematosus 26.66 13.62 60 226262 2506 29345699
Breast feeding 26.61 13.62 8 226314 6 29348199
Increased upper airway secretion 26.53 13.62 45 226277 1521 29346684
Supraventricular tachycardia 26.48 13.62 22 226300 9862 29338343
Intestinal sepsis 26.41 13.62 24 226298 418 29347787
Medical device implantation 26.38 13.62 27 226295 548 29347657
Aplasia pure red cell 26.38 13.62 5 226317 5486 29342719
Hepatitis B virus test positive 26.31 13.62 20 226302 268 29347937
Hypotonia 26.18 13.62 10 226312 6892 29341313
Adverse drug reaction 26.07 13.62 290 226032 23730 29324475
Lung infiltration 26.06 13.62 31 226291 11748 29336457
Schizophrenia 25.77 13.62 9 226313 6556 29341649
Walking aid user 25.76 13.62 43 226279 1434 29346771
Squamous cell carcinoma 25.69 13.62 150 226172 10101 29338104
Interstitial lung disease 25.69 13.62 300 226022 57418 29290787
Intervertebral disc operation 25.68 13.62 18 226304 211 29347994
Accident at work 25.64 13.62 28 226294 614 29347591
Asphyxia 25.20 13.62 5 226317 5310 29342895
Cardiac failure acute 25.20 13.62 20 226302 9172 29339033
Hepatitis acute 25.12 13.62 9 226313 6453 29341752
Device occlusion 25.11 13.62 6 226316 5602 29342603
Graft versus host disease 25.09 13.62 22 226300 9606 29338599
Meningitis viral 25.01 13.62 31 226291 782 29347423
Ejection fraction decreased 24.98 13.62 53 226269 15925 29332280
Chromaturia 24.95 13.62 37 226285 12765 29335440
Drug resistance 24.90 13.62 83 226239 21457 29326748
Cardiomyopathy 24.87 13.62 47 226275 14740 29333465
Onychomadesis 24.84 13.62 25 226297 497 29347708
Obsessive-compulsive disorder 24.65 13.62 3 226319 4573 29343632
Dialysis 24.64 13.62 25 226297 10183 29338022
Bladder cancer 24.62 13.62 147 226175 9980 29338225
Acute graft versus host disease 24.61 13.62 7 226315 5817 29342388
Ventricular hypokinesia 24.57 13.62 3 226319 4562 29343643
Anal incontinence 24.41 13.62 10 226312 6605 29341600
Blood glucose decreased 24.39 13.62 34 226288 12035 29336170
Hepatic cytolysis 24.38 13.62 17 226305 8330 29339875
C-reactive protein increased 24.38 13.62 475 225847 43788 29304417
Wrong product administered 24.33 13.62 3 226319 4528 29343677
Body temperature increased 24.31 13.62 46 226276 14419 29333786
Liver function test increased 24.24 13.62 165 226157 11720 29336485
Ligament operation 24.03 13.62 7 226315 4 29348201
Haemophagocytic lymphohistiocytosis 23.93 13.62 27 226295 10477 29337728
Iron deficiency anaemia 23.83 13.62 20 226302 8922 29339283
Acute pulmonary oedema 23.82 13.62 11 226311 6768 29341437
Product complaint 23.78 13.62 6 226316 5399 29342806
Diabetes mellitus inadequate control 23.71 13.62 35 226287 12099 29336106
Guttate psoriasis 23.64 13.62 15 226307 147 29348058
Injection site hyperaesthesia 23.43 13.62 7 226315 5 29348200
Premature baby 23.29 13.62 62 226260 17218 29330987
Tendon sheath incision 23.28 13.62 6 226316 0 29348205
Tonsil cancer 23.20 13.62 32 226290 899 29347306
Weight increased 23.14 13.62 430 225892 76237 29271968
Ligament rupture 23.07 13.62 31 226291 849 29347356
Exposure to communicable disease 23.05 13.62 14 226308 126 29348079
Amylase increased 22.97 13.62 6 226316 5274 29342931
Bundle branch block left 22.95 13.62 6 226316 5271 29342934
Eosinophil count increased 22.89 13.62 14 226308 7355 29340850
Colitis ischaemic 22.83 13.62 8 226314 5815 29342390
Muscle swelling 22.79 13.62 20 226302 332 29347873
Hyperaesthesia teeth 22.79 13.62 23 226299 459 29347746
Infected bite 22.74 13.62 20 226302 333 29347872
Cerebral haematoma 22.70 13.62 3 226319 4293 29343912
Arteriosclerosis 22.68 13.62 27 226295 10229 29337976
Dental caries 22.63 13.62 77 226245 4103 29344102
Ageusia 22.61 13.62 21 226301 8917 29339288
Ileus paralytic 22.59 13.62 6 226316 5217 29342988
Toxic encephalopathy 22.59 13.62 4 226318 4608 29343597
Gastric ulcer haemorrhage 22.52 13.62 5 226317 4909 29343296
Erectile dysfunction 22.51 13.62 67 226255 17942 29330263
Ventricular hypertrophy 22.47 13.62 3 226319 4261 29343944
Head discomfort 22.42 13.62 65 226257 3177 29345028
Ecchymosis 22.36 13.62 10 226312 6270 29341935
Ischaemia 22.11 13.62 3 226319 4209 29343996
Gastrointestinal disorder 21.99 13.62 325 225997 28381 29319824
International normalised ratio decreased 21.96 13.62 3 226319 4187 29344018
Herpes ophthalmic 21.96 13.62 22 226300 435 29347770
Euphoric mood 21.93 13.62 5 226317 4820 29343385
Cutaneous sarcoidosis 21.91 13.62 14 226308 139 29348066
Haemolysis 21.91 13.62 13 226309 6943 29341262
Blood magnesium decreased 21.86 13.62 7 226315 5387 29342818
Retinal haemorrhage 21.85 13.62 4 226318 4500 29343705
Myositis 21.76 13.62 28 226294 10255 29337950
Pulseless electrical activity 21.75 13.62 11 226311 6423 29341782
Glycosylated haemoglobin increased 21.73 13.62 24 226298 9402 29338803
Haemolytic anaemia 21.69 13.62 24 226298 9395 29338810
Ischaemic cardiomyopathy 21.67 13.62 8 226314 5630 29342575
Sunburn 21.65 13.62 42 226280 1578 29346627
Nail infection 21.65 13.62 16 226306 205 29348000
Blood albumin decreased 21.64 13.62 35 226287 11660 29336545
Mouth haemorrhage 21.63 13.62 5 226317 4775 29343430
Frustration tolerance decreased 21.57 13.62 51 226271 2201 29346004
Embolism 21.56 13.62 13 226309 6883 29341322
Soft tissue swelling 21.48 13.62 19 226303 319 29347886
Pulmonary alveolar haemorrhage 21.43 13.62 11 226311 6369 29341836
Lung consolidation 21.43 13.62 6 226316 5037 29343168
Immune reconstitution inflammatory syndrome 21.35 13.62 17 226305 7785 29340420
Pain of skin 21.30 13.62 71 226251 3744 29344461
Amyotrophic lateral sclerosis 21.27 13.62 30 226292 861 29347344
Cachexia 21.25 13.62 11 226311 6338 29341867
Chest discomfort 21.24 13.62 237 226085 45746 29302459
Decubitus ulcer 21.21 13.62 15 226307 7296 29340909
Red cell distribution width increased 21.15 13.62 5 226317 4702 29343503
Gynaecomastia 21.15 13.62 19 226303 8198 29340007
Lower gastrointestinal haemorrhage 21.13 13.62 19 226303 8194 29340011
Lower respiratory tract infection 21.08 13.62 302 226020 26200 29322005
Post procedural haemorrhage 20.91 13.62 16 226306 7475 29340730
Metastases to bone 20.90 13.62 27 226295 9871 29338334
Brain injury 20.88 13.62 8 226314 5504 29342701
Occupational exposure to product 20.80 13.62 18 226304 293 29347912
Benign prostatic hyperplasia 20.79 13.62 36 226286 11674 29336531
Atrioventricular block 20.68 13.62 14 226308 6968 29341237
Papule 20.68 13.62 63 226259 3166 29345039
Plantar fasciitis 20.63 13.62 36 226286 1245 29346960
Product distribution issue 20.63 13.62 19 226303 337 29347868
Colitis 20.62 13.62 147 226175 31101 29317104
Complication associated with device 20.58 13.62 7 226315 5184 29343021
Wrist surgery 20.52 13.62 13 226309 127 29348078
Fine motor skill dysfunction 20.47 13.62 40 226282 1511 29346694
Blood culture positive 20.30 13.62 5 226317 4572 29343633
Faeces discoloured 20.28 13.62 45 226277 13306 29334899
False positive tuberculosis test 20.25 13.62 6 226316 4 29348201
Systemic lupus erythematosus rash 20.22 13.62 10 226312 57 29348148
Limb mass 20.22 13.62 25 226297 629 29347576
Osteolysis 20.22 13.62 40 226282 1525 29346680
Injection site laceration 20.14 13.62 8 226314 24 29348181
Pulse absent 20.08 13.62 7 226315 5106 29343099
Multiple sclerosis 20.03 13.62 90 226232 5464 29342741
Stomatitis 20.00 13.62 397 225925 36716 29311489
Tooth impacted 19.94 13.62 10 226312 59 29348146
Bradyphrenia 19.90 13.62 4 226318 4210 29343995
Productive cough 19.85 13.62 343 225979 30916 29317289
Cervical vertebral fracture 19.81 13.62 42 226280 1683 29346522
Device dispensing error 19.80 13.62 9 226313 41 29348164
Protein total decreased 19.80 13.62 5 226317 4497 29343708
Road traffic accident 19.78 13.62 194 226128 15367 29332838
Skin irritation 19.77 13.62 77 226245 4384 29343821
Cartilage injury 19.77 13.62 22 226300 493 29347712
Dementia 19.66 13.62 37 226285 11621 29336584
Duodenal ulcer haemorrhage 19.65 13.62 5 226317 4474 29343731
Pathological fracture 19.65 13.62 3 226319 3852 29344353
Injection site anaesthesia 19.58 13.62 7 226315 14 29348191
Incontinence 19.58 13.62 7 226315 5025 29343180
Coronary artery stenosis 19.57 13.62 22 226300 8551 29339654
Intervertebral disc disorder 19.48 13.62 42 226280 1703 29346502
Hangnail 19.40 13.62 5 226317 0 29348205
Tuberculin test 19.40 13.62 5 226317 0 29348205
Bunion operation 19.40 13.62 5 226317 0 29348205
Propionibacterium infection 19.40 13.62 16 226306 243 29347962
Polychondritis 19.39 13.62 13 226309 141 29348064
Lymphadenopathy 19.35 13.62 284 226038 24765 29323440
Nephropathy 19.35 13.62 8 226314 5255 29342950
Neonatal respiratory distress syndrome 19.34 13.62 3 226319 3807 29344398
Dysuria 19.33 13.62 97 226225 22343 29325862
Immunosuppression 19.32 13.62 86 226236 5200 29343005
Gastric ulcer 19.29 13.62 50 226272 14011 29334194
Cardiovascular disorder 19.25 13.62 24 226298 8911 29339294
Hypertensive crisis 19.20 13.62 19 226303 7829 29340376
Device defective 19.18 13.62 21 226301 462 29347743
Animal bite 19.18 13.62 21 226301 462 29347743
Intentional dose omission 18.94 13.62 46 226276 2020 29346185
Cerebral ischaemia 18.91 13.62 10 226312 5693 29342512
Tendon operation 18.81 13.62 8 226314 30 29348175
Haemorrhoids 18.78 13.62 38 226284 11619 29336586
Body temperature abnormal 18.76 13.62 21 226301 474 29347731
Foetal heart rate decreased 18.68 13.62 9 226313 48 29348157
Pulmonary embolism 18.48 13.62 445 225877 76089 29272116
General symptom 18.48 13.62 27 226295 801 29347404
Migraine 18.33 13.62 160 226162 12270 29335935
Rheumatoid factor 18.31 13.62 10 226312 72 29348133
Respiratory syncytial virus infection 18.30 13.62 3 226319 3656 29344549
Mental impairment 18.22 13.62 26 226296 9115 29339090
Immune thrombocytopenia 18.22 13.62 20 226302 7857 29340348
Hospice care 18.16 13.62 8 226314 5060 29343145
Skin cancer 18.14 13.62 119 226203 8349 29339856
Brain herniation 18.12 13.62 3 226319 3630 29344575
Oral candidiasis 18.10 13.62 34 226288 10688 29337517
Blood triglycerides increased 18.10 13.62 45 226277 12789 29335416
Cyst removal 18.04 13.62 8 226314 34 29348171
Taste disorder 17.98 13.62 7 226315 4769 29343436
Wisdom teeth removal 17.98 13.62 10 226312 75 29348130
Whipple's disease 17.85 13.62 6 226316 9 29348196
Partial seizures 17.83 13.62 4 226318 3899 29344306
Thyroid cancer 17.82 13.62 35 226287 1327 29346878
Obesity 17.80 13.62 30 226292 9833 29338372
Injury 17.77 13.62 80 226242 18966 29329239
Maternal drugs affecting foetus 17.76 13.62 4 226318 3889 29344316
Prostatic specific antigen increased 17.76 13.62 44 226278 12520 29335685
Ligament disorder 17.75 13.62 11 226311 103 29348102
Nail discolouration 17.63 13.62 26 226296 778 29347427
HLA-B*27 positive 17.62 13.62 7 226315 21 29348184
Seronegative arthritis 17.61 13.62 28 226294 896 29347309
Mononucleosis syndrome 17.56 13.62 9 226313 56 29348149
Dactylitis 17.51 13.62 24 226298 670 29347535
Miller Fisher syndrome 17.51 13.62 8 226314 37 29348168
Spinal laminectomy 17.49 13.62 15 226307 241 29347964
Generalised oedema 17.48 13.62 37 226285 11128 29337077
Injection site pustule 17.47 13.62 6 226316 10 29348195
Spinal disorder 17.38 13.62 65 226257 3630 29344575
Infected cyst 17.36 13.62 20 226302 466 29347739
Product administration error 17.34 13.62 54 226268 14256 29333949
Nasal cavity cancer 17.31 13.62 12 226310 138 29348067
Hypertriglyceridaemia 17.27 13.62 19 226303 7456 29340749
Stent placement 17.23 13.62 72 226250 4234 29343971
Tendon pain 17.17 13.62 50 226272 2450 29345755
Malignant melanoma stage I 17.14 13.62 10 226312 83 29348122
Weight fluctuation 17.10 13.62 5 226317 4081 29344124
Joint surgery 17.08 13.62 5 226317 3 29348202
Ankle fracture 17.07 13.62 62 226260 3414 29344791
Renal tubular disorder 17.02 13.62 6 226316 4346 29343859
Enterococcal infection 17.00 13.62 23 226299 8245 29339960
C-reactive protein decreased 16.94 13.62 37 226285 1514 29346691
Peripheral ischaemia 16.94 13.62 9 226313 5110 29343095
Manufacturing product shipping issue 16.93 13.62 7 226315 24 29348181
Contraindication to medical treatment 16.89 13.62 19 226303 431 29347774
Ammonia increased 16.75 13.62 5 226317 4026 29344179
Carbuncle 16.72 13.62 7 226315 25 29348180
Sinus node dysfunction 16.71 13.62 4 226318 3730 29344475
Injection site oedema 16.69 13.62 13 226309 181 29348024
Cholecystitis 16.58 13.62 28 226294 9169 29339036
Axial spondyloarthritis 16.57 13.62 15 226307 260 29347945
Pneumocystis jirovecii pneumonia 16.56 13.62 69 226253 16710 29331495
Affect lability 16.55 13.62 3 226319 3399 29344806
Appendicitis 16.50 13.62 26 226296 8753 29339452
Skin swelling 16.50 13.62 29 226293 1009 29347196
Cholelithiasis 16.50 13.62 80 226242 18592 29329613
Nasal discharge discolouration 16.48 13.62 14 226308 222 29347983
Metabolic disorder 16.46 13.62 4 226318 3691 29344514
Device dislocation 16.45 13.62 7 226315 4520 29343685
Injection site discharge 16.38 13.62 10 226312 91 29348114
Aplastic anaemia 16.36 13.62 20 226302 7490 29340715
Dysgeusia 16.29 13.62 104 226218 22570 29325635
Muscle haemorrhage 16.28 13.62 3 226319 3359 29344846
Jaundice cholestatic 16.23 13.62 6 226316 4220 29343985
Peripheral sensory neuropathy 16.18 13.62 13 226309 5926 29342279
Lower limb fracture 16.16 13.62 63 226259 3589 29344616
Flatulence 16.16 13.62 75 226247 17634 29330571
Eating disorder 16.11 13.62 19 226303 7228 29340977
Carotid artery stenosis 16.10 13.62 7 226315 4462 29343743
Stress at work 16.09 13.62 12 226310 156 29348049
Hemiplegia 16.09 13.62 16 226306 6578 29341627
Therapeutic response shortened 16.07 13.62 76 226246 4715 29343490
Gingival discolouration 15.97 13.62 5 226317 5 29348200
Adenovirus infection 15.96 13.62 7 226315 4440 29343765
Ear neoplasm 15.91 13.62 9 226313 70 29348135
Intervertebral disc injury 15.88 13.62 6 226316 15 29348190
Pulmonary function test decreased 15.84 13.62 6 226316 4157 29344048
Septic arthritis staphylococcal 15.80 13.62 19 226303 464 29347741
Aspergillus infection 15.80 13.62 36 226286 10545 29337660
Swollen tongue 15.79 13.62 45 226277 12221 29335984
Spinal fusion acquired 15.74 13.62 7 226315 30 29348175
Periarthritis 15.53 13.62 26 226296 869 29347336
Myelitis 15.52 13.62 23 226299 691 29347514
Anticipatory anxiety 15.52 13.62 4 226318 0 29348205
Cast application 15.52 13.62 4 226318 0 29348205
Serum ferritin increased 15.52 13.62 12 226310 5576 29342629
Secondary amyloidosis 15.50 13.62 9 226313 74 29348131
Lip and/or oral cavity cancer 15.49 13.62 15 226307 284 29347921
Muscle tightness 15.42 13.62 70 226252 4268 29343937
Asthma 15.42 13.62 175 226147 33674 29314531
Scar 15.38 13.62 82 226240 5337 29342868
Sudden cardiac death 15.34 13.62 3 226319 3219 29344986
Erythema multiforme 15.34 13.62 22 226300 7695 29340510
Skin lesion 15.31 13.62 213 226109 18359 29329846
Cholecystitis acute 15.31 13.62 11 226311 5308 29342897
Drug screen positive 15.28 13.62 5 226317 3796 29344409
Thrombotic thrombocytopenic purpura 15.23 13.62 3 226319 3203 29345002
Intestinal perforation 15.15 13.62 24 226298 8062 29340143
Upper-airway cough syndrome 15.12 13.62 54 226268 2949 29345256
Intracranial pressure increased 15.08 13.62 4 226318 3481 29344724
Gastrointestinal perforation 15.07 13.62 4 226318 3479 29344726
Papillary cystadenoma lymphomatosum 15.05 13.62 7 226315 34 29348171
Mixed connective tissue disease 15.05 13.62 7 226315 34 29348171
Necrosis 15.02 13.62 10 226312 5020 29343185
Abdominal operation 15.01 13.62 9 226313 79 29348126
Seminoma 15.00 13.62 13 226309 212 29347993
Pneumatosis intestinalis 14.98 13.62 3 226319 3166 29345039
Device leakage 14.85 13.62 71 226251 4424 29343781
Precancerous skin lesion 14.76 13.62 20 226302 552 29347653
Tendonitis 14.76 13.62 108 226214 7853 29340352
Antiphospholipid syndrome 14.73 13.62 17 226305 397 29347808
Anger 14.73 13.62 39 226283 10851 29337354
Eye infection 14.65 13.62 52 226270 2831 29345374
Axillary mass 14.57 13.62 10 226312 113 29348092
Non-cardiac chest pain 14.57 13.62 6 226316 3951 29344254
Renal cancer 14.57 13.62 70 226252 4371 29343834
Metabolic encephalopathy 14.56 13.62 5 226317 3682 29344523
Blood thyroid stimulating hormone increased 14.55 13.62 3 226319 3102 29345103
BK virus infection 14.54 13.62 9 226313 4698 29343507
Bacterial sepsis 14.52 13.62 9 226313 4694 29343511
Oesophageal infection 14.51 13.62 14 226308 264 29347941
Nasal discomfort 14.49 13.62 30 226292 1182 29347023
Abnormal dreams 14.48 13.62 19 226303 6901 29341304
Protein urine present 14.47 13.62 9 226313 4685 29343520
Pyelonephritis 14.45 13.62 12 226310 5381 29342824
Alcohol poisoning 14.45 13.62 3 226319 3086 29345119
Fibrin D dimer increased 14.44 13.62 3 226319 3085 29345120
Tongue disorder 14.44 13.62 72 226250 4564 29343641
Neutrophilia 14.43 13.62 5 226317 3661 29344544
Arthroscopy 14.37 13.62 9 226313 86 29348119
X-ray abnormal 14.34 13.62 18 226304 460 29347745
Odynophagia 14.33 13.62 9 226313 4661 29343544
Drug use disorder 14.31 13.62 58 226264 3364 29344841
Cytomegalovirus infection reactivation 14.30 13.62 4 226318 3360 29344845
Muscle spasticity 14.19 13.62 10 226312 4873 29343332
Nail bed bleeding 14.14 13.62 7 226315 40 29348165
Gastric operation 14.14 13.62 7 226315 40 29348165
Colonoscopy 14.11 13.62 22 226300 692 29347513
Sinus polyp 14.07 13.62 11 226311 154 29348051
Diaphragmatic injury 14.07 13.62 10 226312 120 29348085
Oral infection 14.07 13.62 38 226284 1782 29346423
Systemic inflammatory response syndrome 14.04 13.62 15 226307 5966 29342239
Vascular graft 14.04 13.62 32 226290 1348 29346857
Benign neoplasm of thyroid gland 14.01 13.62 6 226316 23 29348182
Drooling 13.99 13.62 3 226319 3018 29345187
Extradural abscess 13.97 13.62 20 226302 582 29347623
Lupus nephritis 13.96 13.62 13 226309 234 29347971
Dental discomfort 13.96 13.62 8 226314 64 29348141
Portal vein thrombosis 13.94 13.62 4 226318 3305 29344900
Tinea infection 13.93 13.62 12 226310 194 29348011
Granuloma 13.88 13.62 46 226276 2418 29345787
Hypertonia 13.79 13.62 6 226316 3823 29344382
Dental care 13.78 13.62 12 226310 197 29348008
Pneumonia bacterial 13.78 13.62 32 226290 9311 29338894
Dermatitis acneiform 13.77 13.62 13 226309 5478 29342727
Retroperitoneal fibrosis 13.77 13.62 14 226308 282 29347923
Spinal stenosis 13.76 13.62 68 226254 4295 29343910
Tendon disorder 13.73 13.62 46 226276 2432 29345773
Intraocular pressure increased 13.66 13.62 10 226312 4779 29343426
Dermatitis bullous 13.65 13.62 15 226307 5891 29342314
Tachyarrhythmia 13.65 13.62 3 226319 2966 29345239

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Injection site pain 49774.43 13.74 26120 863017 85288 63524307
Injection site erythema 47284.38 13.74 21847 867290 48953 63560642
Injection site pruritus 25986.39 13.74 11923 877214 25903 63583692
Injection site swelling 25814.33 13.74 12198 876939 29155 63580440
Injection site reaction 18577.86 13.74 10162 878975 36502 63573093
Injection site bruising 16545.93 13.74 8658 880479 27715 63581880
Injection site warmth 13456.68 13.74 5534 883603 7928 63601667
Arthralgia 10888.48 13.74 20754 868383 421506 63188089
Drug ineffective 9143.13 13.74 28755 860382 811492 62798103
Wrong technique in product usage process 8543.25 13.74 7113 882024 57861 63551734
Injection site rash 8030.68 13.74 4051 885086 11691 63597904
Injection site haemorrhage 7860.30 13.74 4623 884514 19655 63589940
Injection site urticaria 6234.26 13.74 3057 886080 8124 63601471
Joint swelling 5858.24 13.74 10574 878563 204808 63404787
Pain in extremity 5711.43 13.74 12765 876372 290320 63319275
Pain 4896.79 13.74 17718 871419 535793 63073802
Nasopharyngitis 4796.80 13.74 9201 879936 186872 63422723
Acute kidney injury 4713.26 13.74 401 888736 448839 63160756
Product dose omission issue 4385.44 13.74 8827 880310 185920 63423675
Injection site discolouration 4302.74 13.74 2035 887102 4840 63604755
Sinusitis 4170.22 13.74 7326 881811 138602 63470993
Product storage error 4147.10 13.74 2474 886663 10844 63598751
Therapeutic product effect incomplete 4115.21 13.74 6040 883097 97442 63512153
Therapeutic product effect decreased 4049.48 13.74 6353 882784 108998 63500597
Toxicity to various agents 3907.37 13.74 290 888847 363223 63246372
Injection site induration 3820.85 13.74 2043 887094 6889 63602706
Drug interaction 3793.68 13.74 324 888813 361759 63247836
Device issue 3766.10 13.74 2849 886288 19799 63589796
Accidental exposure to product 3494.12 13.74 2902 886235 23462 63586133
Musculoskeletal stiffness 3406.15 13.74 6098 883039 117108 63492487
Hypotension 3397.44 13.74 584 888553 380390 63229205
Completed suicide 2953.48 13.74 25 889112 224389 63385206
Mobility decreased 2940.92 13.74 4677 884460 81163 63528432
Injection site mass 2932.24 13.74 2200 886937 15070 63594525
Anaemia 2827.32 13.74 856 888281 377824 63231771
Death 2681.32 13.74 1676 887461 481029 63128566
Swelling 2500.52 13.74 6280 882857 153938 63455657
Febrile neutropenia 2275.06 13.74 68 889069 187589 63422006
Therapeutic response decreased 2233.24 13.74 3156 885981 49032 63560563
Joint stiffness 2131.24 13.74 2355 886782 28049 63581546
Neutropenia 2115.05 13.74 376 888761 239248 63370347
Musculoskeletal pain 2088.53 13.74 3900 885237 77394 63532201
Treatment failure 2015.91 13.74 4761 884376 112055 63497540
Underdose 1998.64 13.74 2108 887029 23721 63585874
Dyspnoea 1987.66 13.74 4358 884779 714316 62895279
Thrombocytopenia 1975.46 13.74 351 888786 223450 63386145
Arthritis 1953.11 13.74 3858 885279 79956 63529639
Injection site discomfort 1819.18 13.74 972 888165 3269 63606326
Hyponatraemia 1796.89 13.74 54 889083 148285 63461310
Drug abuse 1690.11 13.74 26 889111 132348 63477247
Arthropathy 1649.26 13.74 4510 884627 116457 63493138
Cardiac arrest 1578.47 13.74 150 888987 153914 63455681
Peripheral swelling 1538.56 13.74 6331 882806 202822 63406773
Malignant neoplasm progression 1496.84 13.74 10 889127 112861 63496734
Dehydration 1490.42 13.74 562 888575 216201 63393394
Psoriasis 1479.24 13.74 3139 885998 68564 63541031
Injection site haematoma 1458.61 13.74 819 888318 3117 63606478
Constipation 1432.32 13.74 685 888452 228652 63380943
Bradycardia 1424.58 13.74 45 889092 118174 63491421
Diarrhoea 1417.67 13.74 5165 883972 717539 62892056
Injection site extravasation 1401.23 13.74 1043 888094 7043 63602552
Abdominal pain 1376.68 13.74 1366 887771 311009 63298586
Drug intolerance 1371.66 13.74 5677 883460 182315 63427280
Vomiting 1359.43 13.74 3545 885592 547572 63062023
Respiratory failure 1355.84 13.74 284 888853 160899 63448696
Respiratory tract congestion 1327.14 13.74 1362 887775 14803 63594792
Synovitis 1316.19 13.74 3660 885477 95430 63514165
Tachycardia 1299.10 13.74 244 888893 149335 63460260
Contraindicated product administered 1287.38 13.74 3833 885304 103996 63505599
Hyperkalaemia 1286.05 13.74 21 889116 101108 63508487
Haemoglobin decreased 1275.11 13.74 546 888591 194517 63415078
Pancytopenia 1254.81 13.74 229 888908 143080 63466515
Gastrointestinal haemorrhage 1254.48 13.74 169 888968 132143 63477452
Knee arthroplasty 1247.85 13.74 1695 887442 25304 63584291
Confusional state 1247.59 13.74 1060 888077 260084 63349511
Skin plaque 1229.87 13.74 1006 888131 7934 63601661
Hypokalaemia 1216.56 13.74 131 889006 121772 63487823
Seizure 1215.23 13.74 393 888744 166499 63443096
Disease progression 1203.23 13.74 244 888893 141436 63468159
Overdose 1184.57 13.74 363 888774 159203 63450392
Rhabdomyolysis 1162.41 13.74 20 889117 91706 63517889
Cardio-respiratory arrest 1139.02 13.74 51 889086 98342 63511253
Intentional overdose 1126.03 13.74 23 889114 89921 63519674
Platelet count decreased 1104.71 13.74 464 888673 167247 63442348
Renal failure 1103.41 13.74 563 888574 181125 63428470
Syncope 1067.75 13.74 418 888719 157217 63452378
Oropharyngeal pain 1057.73 13.74 3156 885981 85711 63523884
Musculoskeletal disorder 1047.91 13.74 1264 887873 16642 63592953
Electrocardiogram QT prolonged 1038.92 13.74 10 889127 79438 63530157
Sepsis 1033.05 13.74 991 888146 229350 63380245
Surgery 1030.17 13.74 1584 887553 26629 63582966
Atrial fibrillation 1011.09 13.74 549 888588 170540 63439055
Decreased appetite 997.78 13.74 1457 887680 279832 63329763
Hypoglycaemia 989.29 13.74 63 889074 89829 63519766
Hypoxia 975.42 13.74 60 889077 88089 63521506
Oxygen saturation decreased 947.35 13.74 167 888970 107009 63502586
International normalised ratio increased 947.03 13.74 32 889105 79135 63530460
Influenza 946.91 13.74 3426 885711 103105 63506490
Depressed level of consciousness 927.13 13.74 47 889090 81389 63528206
Blood creatinine increased 919.61 13.74 360 888777 135422 63474173
Injection site macule 893.64 13.74 319 888818 210 63609385
Somnolence 888.96 13.74 897 888240 202748 63406847
Cardiac failure 884.95 13.74 358 888779 132015 63477580
Agitation 871.39 13.74 99 889038 88268 63521327
Cardiac failure congestive 868.31 13.74 356 888781 130224 63479371
Bronchitis 868.31 13.74 3379 885758 105364 63504231
Injection site recall reaction 866.12 13.74 288 888849 99 63609496
Product use in unapproved indication 861.38 13.74 702 888435 175916 63433679
Finger deformity 854.28 13.74 649 888488 4537 63605058
Psoriatic arthropathy 850.11 13.74 1858 887279 41423 63568172
Multiple organ dysfunction syndrome 849.88 13.74 180 888957 101233 63508362
Metabolic acidosis 844.15 13.74 30 889107 70928 63538667
Coma 834.91 13.74 110 889027 87505 63522090
Lactic acidosis 821.54 13.74 4 889133 61406 63548189
Incorrect dose administered by device 792.80 13.74 565 888572 3532 63606063
Nodule 780.11 13.74 1094 888043 16853 63592742
Pulmonary embolism 778.99 13.74 531 888606 145825 63463770
Suicide attempt 768.88 13.74 54 889083 70953 63538642
Neutrophil count decreased 767.43 13.74 84 889053 77112 63532483
Injection site vesicles 745.98 13.74 461 888676 2179 63607416
Pleural effusion 740.47 13.74 411 888726 126148 63483447
Headache 723.36 13.74 10764 878373 518703 63090892
Blood pressure decreased 722.26 13.74 153 888984 86046 63523549
Infection 717.26 13.74 4683 884454 180197 63429398
Injury associated with device 713.15 13.74 461 888676 2392 63607203
Unevaluable event 710.94 13.74 1906 887231 48583 63561012
Therapy non-responder 704.65 13.74 2255 886882 63644 63545951
Renal impairment 701.16 13.74 503 888634 134514 63475081
General physical health deterioration 700.12 13.74 1084 888053 203341 63406254
C-reactive protein abnormal 685.57 13.74 1345 887792 27702 63581893
Mental status changes 657.93 13.74 48 889089 61114 63548481
Asthenia 655.65 13.74 3354 885783 424690 63184905
Fear of injection 655.61 13.74 588 888549 5324 63604271
Condition aggravated 651.32 13.74 7919 881218 364507 63245088
Foot deformity 644.20 13.74 956 888181 15548 63594047
Hallucination 644.09 13.74 113 889024 72675 63536920
Deep vein thrombosis 641.15 13.74 324 888813 104858 63504737
White blood cell count decreased 638.90 13.74 740 888397 157097 63452498
Rhinorrhoea 638.36 13.74 2049 887088 57920 63551675
Acute myocardial infarction 637.48 13.74 99 889038 69619 63539976
Injection site irritation 636.60 13.74 451 888686 2789 63606806
Drug reaction with eosinophilia and systemic symptoms 634.37 13.74 26 889111 54191 63555404
Red blood cell sedimentation rate abnormal 631.40 13.74 941 888196 15365 63594230
Paranasal sinus hypersecretion 624.65 13.74 438 888699 2658 63606937
Pulmonary oedema 622.67 13.74 158 888979 78516 63531079
Hyperglycaemia 622.43 13.74 60 889077 60908 63548687
Pneumonia aspiration 605.97 13.74 58 889079 59213 63550382
Loss of consciousness 605.46 13.74 691 888446 147674 63461921
Ear infection 601.90 13.74 1124 888013 22280 63587315
Blood bilirubin increased 599.99 13.74 52 889085 57501 63552094
Melaena 596.75 13.74 35 889102 53513 63556082
Blood creatine phosphokinase increased 594.21 13.74 59 889078 58499 63551096
Inflammation 591.82 13.74 2114 887023 63186 63546409
Hypersensitivity 591.55 13.74 4682 884455 191770 63417825
Grip strength decreased 584.56 13.74 764 888373 10960 63598635
Injection site inflammation 581.73 13.74 426 888711 2795 63606800
Respiratory arrest 577.41 13.74 39 889098 52946 63556649
Weight decreased 576.77 13.74 2013 887124 283726 63325869
Septic shock 575.17 13.74 372 888765 105065 63504530
Ascites 571.55 13.74 86 889051 61915 63547680
Unresponsive to stimuli 570.67 13.74 30 889107 50363 63559232
Alanine aminotransferase increased 563.55 13.74 651 888486 138380 63471215
Encephalopathy 557.60 13.74 75 889062 58744 63550851
Pyrexia 551.72 13.74 4986 884151 553658 63055937
Drug hypersensitivity 549.49 13.74 5347 883790 232468 63377127
Delirium 543.68 13.74 141 888996 69053 63540542
Coronary artery disease 540.90 13.74 91 889046 60342 63549253
Alopecia 533.82 13.74 4012 885125 161678 63447917
Blood alkaline phosphatase increased 525.87 13.74 75 889062 56204 63553391
Multiple sclerosis relapse 525.15 13.74 8 889129 41127 63568468
Orthostatic hypotension 522.50 13.74 30 889107 46708 63562887
Drug dose omission by device 522.27 13.74 411 888726 3046 63606549
Dysarthria 521.75 13.74 94 889043 59312 63550283
Mucosal inflammation 518.33 13.74 114 889023 62470 63547125
Nausea 517.81 13.74 7677 881460 778123 62831472
Hand deformity 513.41 13.74 1966 887171 60805 63548790
Neck pain 512.99 13.74 1939 887198 59594 63550001
Respiratory distress 512.44 13.74 60 889077 52271 63557324
Neoplasm progression 510.55 13.74 11 889126 40953 63568642
Upper respiratory tract infection 507.23 13.74 2169 886968 70616 63538979
Sedation 505.81 13.74 14 889123 41448 63568147
Blood pressure increased 505.44 13.74 1009 888128 171543 63438052
Pharyngitis streptococcal 504.06 13.74 610 888527 8058 63601537
Hip arthroplasty 503.05 13.74 988 888149 20363 63589232
Aspartate aminotransferase increased 499.53 13.74 548 888589 119240 63490355
Herpes zoster 496.84 13.74 2287 886850 76900 63532695
Serotonin syndrome 495.80 13.74 9 889128 39273 63570322
Tremor 495.01 13.74 799 888338 147431 63462164
Gait disturbance 488.34 13.74 4048 885089 168107 63441488
Bone marrow failure 487.36 13.74 48 889089 47904 63561691
Contusion 483.33 13.74 2954 886183 111011 63498584
Therapy interrupted 475.51 13.74 930 888207 19106 63590489
Sinus congestion 473.64 13.74 801 888336 14638 63594957
Leukopenia 473.03 13.74 419 888718 100823 63508772
Pneumonia 472.38 13.74 5186 883951 554390 63055205
Haematuria 471.71 13.74 125 889012 60346 63549249
Gamma-glutamyltransferase increased 471.59 13.74 57 889080 48453 63561142
Hepatic failure 468.80 13.74 96 889041 55298 63554297
Haematemesis 462.41 13.74 53 889084 46946 63562649
Hypomagnesaemia 462.07 13.74 11 889126 37365 63572230
Dyspnoea exertional 460.07 13.74 220 888917 73510 63536085
Fall 458.83 13.74 3614 885523 413212 63196383
Aggression 452.71 13.74 53 889084 46179 63563416
Chest pain 452.48 13.74 1698 887439 234282 63375313
Urinary retention 451.77 13.74 69 889068 49132 63560463
Blood urea increased 449.25 13.74 44 889093 44109 63565486
Feeling abnormal 445.53 13.74 3262 885875 130340 63479255
Heart rate increased 443.67 13.74 423 888714 98252 63511343
Disorientation 441.99 13.74 112 889025 55716 63553879
Cholestasis 440.48 13.74 51 889086 44821 63564774
Oedema 438.59 13.74 373 888764 91562 63518033
Cerebrovascular accident 435.95 13.74 767 888370 136816 63472779
Jaundice 434.26 13.74 73 889064 48439 63561156
Acute respiratory failure 434.24 13.74 81 889056 49853 63559742
Joint range of motion decreased 432.80 13.74 876 888261 18467 63591128
Lymphocyte count decreased 431.89 13.74 34 889103 40665 63568930
Cerebral haemorrhage 431.40 13.74 89 889048 51001 63558594
Bone erosion 427.42 13.74 654 888483 10941 63598654
Drug level increased 426.90 13.74 9 889128 34187 63575408
Loss of personal independence in daily activities 425.62 13.74 2053 887084 70401 63539194
Hypervolaemia 423.64 13.74 26 889111 38259 63571336
Red blood cell sedimentation rate increased 421.47 13.74 1161 887976 30074 63579521
Toxic epidermal necrolysis 415.02 13.74 24 889113 37142 63572453
Back pain 414.81 13.74 5269 883868 244902 63364693
Agranulocytosis 414.04 13.74 29 889108 38200 63571395
Sinus headache 413.22 13.74 391 888746 3816 63605779
Chronic kidney disease 413.20 13.74 141 888996 57778 63551817
Plasma cell myeloma 413.18 13.74 69 889068 46006 63563589
Dizziness 412.07 13.74 3867 885270 426296 63183299
Suicidal ideation 411.45 13.74 201 888936 66341 63543254
Shock 411.30 13.74 30 889107 38210 63571385
Cough 410.48 13.74 6141 882996 296007 63313588
Myocardial infarction 405.26 13.74 1069 888068 164752 63444843
Hepatocellular injury 400.66 13.74 70 889067 45165 63564430
Dysphagia 399.34 13.74 532 888605 106280 63503315
Adverse event 398.35 13.74 1325 887812 38164 63571431
Hypertension 397.08 13.74 2030 887107 257231 63352364
Impaired healing 391.56 13.74 1763 887374 58710 63550885
Knee operation 386.80 13.74 391 888746 4166 63605429
Angioedema 380.33 13.74 188 888949 61633 63547962
Upper gastrointestinal haemorrhage 374.92 13.74 29 889108 35191 63574404
Altered state of consciousness 374.74 13.74 42 889095 37860 63571735
Eosinophilia 374.44 13.74 43 889094 38033 63571562
Heart rate decreased 374.29 13.74 145 888992 54922 63554673
Haematocrit decreased 371.35 13.74 144 888993 54511 63555084
Hypocalcaemia 366.79 13.74 66 889071 41687 63567908
Ventricular tachycardia 365.35 13.74 28 889109 34237 63575358
Rash maculo-papular 365.29 13.74 98 889039 46928 63562667
Pancreatitis acute 365.28 13.74 73 889064 42782 63566813
Psychotic disorder 363.81 13.74 30 889107 34548 63575047
Cardiogenic shock 361.90 13.74 21 889116 32406 63577189
Generalised tonic-clonic seizure 361.17 13.74 58 889079 39799 63569796
Rectal haemorrhage 359.62 13.74 202 888935 61615 63547980
Malaise 358.82 13.74 7551 881586 388696 63220899
Injection site hypersensitivity 358.60 13.74 246 888891 1433 63608162
Circulatory collapse 358.44 13.74 28 889109 33704 63575891
Drug withdrawal syndrome 356.28 13.74 18 889119 31273 63578322
Exposure during pregnancy 356.21 13.74 327 888810 77348 63532247
Blood glucose increased 353.04 13.74 502 888635 97571 63512024
Disability 353.02 13.74 616 888521 11556 63598039
Neuropathy peripheral 352.01 13.74 678 888459 116847 63492748
Osteonecrosis of jaw 349.74 13.74 63 889074 39762 63569833
Pulmonary hypertension 348.39 13.74 83 889054 43056 63566539
Joint destruction 347.76 13.74 333 888804 3303 63606292
Sneezing 347.55 13.74 696 888441 14555 63595040
Injection site nodule 345.86 13.74 315 888822 2915 63606680
Nasal congestion 345.74 13.74 1684 887453 57974 63551621
Foot operation 344.25 13.74 355 888782 3880 63605715
Haemorrhage 343.07 13.74 352 888785 78999 63530596
Flushing 342.17 13.74 347 888790 78301 63531294
Transplant dysfunction 340.44 13.74 441 888696 6267 63603328
Arrhythmia 339.56 13.74 152 888985 52792 63556803
Cerebral infarction 337.37 13.74 76 889061 40968 63568627
Accidental overdose 337.35 13.74 35 889102 33522 63576073
Haematochezia 336.99 13.74 253 888884 66120 63543475
Blood pressure systolic increased 336.48 13.74 130 889007 49323 63560272
Stevens-Johnson syndrome 335.99 13.74 39 889098 34210 63575385
Sinus tachycardia 335.71 13.74 29 889108 32159 63577436
Intentional self-injury 329.76 13.74 17 889120 29027 63580568
Blood lactate dehydrogenase increased 328.69 13.74 36 889101 33042 63576553
Rheumatoid factor positive 328.43 13.74 1145 887992 33793 63575802
Neuroleptic malignant syndrome 327.41 13.74 3 889134 24993 63584602
Leukocytosis 326.49 13.74 62 889075 37678 63571917
Osteoarthritis 323.79 13.74 1726 887411 61610 63547985
Spinal operation 323.52 13.74 411 888726 5722 63603873
Therapeutic product effect delayed 322.98 13.74 274 888863 2285 63607310
Diabetic ketoacidosis 322.17 13.74 23 889114 29822 63579773
Sinus disorder 319.65 13.74 715 888422 16193 63593402
Increased tendency to bruise 316.06 13.74 504 888633 8751 63600844
Myoclonus 315.99 13.74 6 889131 25112 63584483
Therapy cessation 314.33 13.74 1075 888062 31414 63578181
Acute hepatic failure 310.66 13.74 11 889126 26101 63583494
Arthropod bite 310.53 13.74 422 888715 6299 63603296
Adverse reaction 305.34 13.74 449 888688 7238 63602357
Acute respiratory distress syndrome 304.57 13.74 80 889057 38855 63570740
Abnormal behaviour 304.49 13.74 49 889088 33573 63576022
Intentional product misuse 303.89 13.74 1870 887267 70425 63539170
Cognitive disorder 303.57 13.74 192 888945 54895 63554700
Anxiety 303.23 13.74 1599 887538 201050 63408545
Tooth infection 302.88 13.74 641 888496 13960 63595635
Adverse drug reaction 302.25 13.74 1336 887801 44128 63565467
Oedema peripheral 298.50 13.74 1689 887448 208628 63400967
Injection site injury 297.54 13.74 156 888981 499 63609096
Acne 295.74 13.74 842 888295 22239 63587356
Haematoma 293.14 13.74 135 889002 46115 63563480
Fibromyalgia 292.00 13.74 1119 888018 34612 63574983
Tachypnoea 291.14 13.74 19 889118 26552 63583043
Subdural haematoma 290.62 13.74 26 889111 28028 63581567
Inappropriate antidiuretic hormone secretion 290.43 13.74 3 889134 22286 63587309
Pulmonary arterial hypertension 287.52 13.74 15 889122 25352 63584243
Posterior reversible encephalopathy syndrome 286.58 13.74 6 889131 22940 63586655
Aphasia 285.91 13.74 103 889034 40803 63568792
Ejection fraction decreased 285.86 13.74 31 889106 28676 63580919
Haemorrhage intracranial 284.36 13.74 10 889127 23874 63585721
Labelled drug-drug interaction medication error 282.86 13.74 4 889133 22058 63587537
Hallucination, visual 282.48 13.74 28 889109 27806 63581789
Limb discomfort 282.28 13.74 921 888216 26254 63583341
Coagulopathy 279.21 13.74 51 889086 31869 63577726
Fluid retention 277.99 13.74 247 888890 59359 63550236
Localised infection 277.93 13.74 982 888155 29179 63580416
Epilepsy 275.77 13.74 62 889075 33469 63576126
Renal tubular necrosis 275.28 13.74 6 889131 22104 63587491
Device expulsion 274.69 13.74 3 889134 21133 63588462
Drug-induced liver injury 272.38 13.74 159 888978 47484 63562111
Poisoning 272.15 13.74 6 889131 21873 63587722
Sleep disorder due to general medical condition, insomnia type 271.68 13.74 889 888248 25381 63584214
Pancreatitis 270.85 13.74 253 888884 59354 63550241
Blood pressure fluctuation 270.76 13.74 192 888945 51679 63557916
Status epilepticus 269.24 13.74 6 889131 21657 63587938
Joint lock 268.34 13.74 258 888879 2573 63607022
Small intestinal obstruction 266.99 13.74 14 889123 23559 63586036
Device malfunction 266.84 13.74 684 888453 16949 63592646
Restlessness 266.69 13.74 107 889030 39678 63569917
Extra dose administered 266.28 13.74 393 888744 6357 63603238
Chondrolysis 265.12 13.74 117 889020 220 63609375
Hepatic function abnormal 264.96 13.74 297 888840 64016 63545579
Tubulointerstitial nephritis 264.79 13.74 52 889085 30857 63578738
Haemoptysis 264.75 13.74 175 888962 48873 63560722
Sinus bradycardia 264.41 13.74 12 889125 22881 63586714
Systemic lupus erythematosus 263.74 13.74 1904 887233 75708 63533887
Neutropenic sepsis 263.02 13.74 14 889123 23258 63586337
Iritis 261.99 13.74 266 888871 2850 63606745
Electrolyte imbalance 259.86 13.74 24 889113 25219 63584376
Skin haemorrhage 258.82 13.74 442 888695 8143 63601452
Pericardial effusion 257.58 13.74 109 889028 39145 63570450
Ischaemic stroke 256.98 13.74 45 889092 28990 63580605
Clostridium difficile colitis 254.95 13.74 36 889101 27187 63582408
Hepatic encephalopathy 253.71 13.74 8 889129 21058 63588537
Shoulder arthroplasty 253.23 13.74 245 888892 2464 63607131
Angina pectoris 252.73 13.74 154 888983 44927 63564668
Mycobacterium tuberculosis complex test positive 251.86 13.74 216 888921 1831 63607764
Palpitations 251.84 13.74 678 888459 103810 63505785
Dyskinesia 251.14 13.74 114 889023 39274 63570321
Ventricular fibrillation 250.20 13.74 21 889116 23839 63585756
Cytomegalovirus infection 249.43 13.74 100 889037 37099 63572496
Rheumatoid nodule 244.80 13.74 540 888597 12111 63597484
Myelosuppression 244.40 13.74 23 889114 23807 63585788
Hyperbilirubinaemia 242.05 13.74 12 889125 21193 63588402
Pneumonitis 241.81 13.74 203 888934 50162 63559433
Disseminated intravascular coagulation 240.90 13.74 73 889064 32275 63577320
Right ventricular failure 239.31 13.74 14 889123 21457 63588138
Decreased immune responsiveness 239.26 13.74 301 888836 4147 63605448
Corrective lens user 238.98 13.74 98 889039 138 63609457
Spinal fusion surgery 238.96 13.74 273 888864 3378 63606217
Transaminases increased 236.81 13.74 162 888975 44432 63565163
Medication error 236.70 13.74 204 888933 49762 63559833
Lethargy 235.97 13.74 398 888739 72196 63537399
Blood calcium decreased 234.22 13.74 36 889101 25518 63584077
Chondropathy 233.93 13.74 220 888917 2129 63607466
Abdominal distension 232.01 13.74 622 888515 95372 63514223
Extrapyramidal disorder 229.97 13.74 9 889128 19543 63590052
Joint noise 228.84 13.74 251 888886 2960 63606635
Urinary incontinence 228.37 13.74 106 889031 36045 63573550
Shoulder operation 227.94 13.74 208 888929 1930 63607665
Hypothermia 227.40 13.74 11 889126 19845 63589750
Joint arthroplasty 226.40 13.74 203 888934 1837 63607758
Anuria 225.57 13.74 8 889129 18956 63590639
Hemiparesis 224.50 13.74 66 889071 29761 63579834
Cyanosis 222.98 13.74 23 889114 22132 63587463
Colitis 221.53 13.74 290 888847 58384 63551211
Ovarian cyst 220.82 13.74 477 888660 10541 63599054
Withdrawal syndrome 220.16 13.74 31 889106 23461 63586134
Ileus 218.32 13.74 29 889108 22937 63586658
Rubber sensitivity 217.86 13.74 166 888971 1166 63608429
Blood pressure diastolic decreased 217.25 13.74 26 889111 22275 63587320
Acidosis 217.08 13.74 6 889131 17789 63591806
Ear pain 216.83 13.74 801 888336 24335 63585260
Rash pruritic 215.47 13.74 1443 887694 55961 63553634
Presyncope 215.37 13.74 107 889030 34982 63574613
Hypophagia 215.35 13.74 140 888997 39447 63570148
Limb operation 214.63 13.74 228 888909 2586 63607009
Brain oedema 214.40 13.74 26 889111 22049 63587546
Dystonia 214.30 13.74 11 889126 18854 63590741
Joint effusion 212.60 13.74 531 888606 12942 63596653
Bacteraemia 211.05 13.74 55 889082 26856 63582739
Stress 210.25 13.74 1493 887644 59041 63550554
Impaired work ability 209.58 13.74 570 888567 14649 63594946
Gastritis 209.28 13.74 168 888969 42450 63567145
Cardiomegaly 208.97 13.74 37 889100 23647 63585948
Obstructive airways disorder 207.25 13.74 35 889102 23150 63586445
Face oedema 207.25 13.74 44 889093 24717 63584878
Tumour lysis syndrome 206.93 13.74 16 889121 19424 63590171
Skin discolouration 206.25 13.74 998 888139 34257 63575338
Lymphopenia 205.92 13.74 50 889087 25607 63583988
Pruritus 205.25 13.74 5699 883438 306701 63302894
Blood potassium decreased 205.05 13.74 154 888983 40245 63569350
Breast cancer 204.79 13.74 871 888266 28277 63581318
Emotional distress 203.57 13.74 122 889015 35916 63573679
Balance disorder 199.66 13.74 548 888589 83378 63526217
Intentional product use issue 199.39 13.74 661 888476 94703 63514892
Gastrooesophageal reflux disease 198.46 13.74 542 888595 82601 63526994
Tuberculin test positive 198.43 13.74 228 888909 2840 63606755
Joint warmth 198.24 13.74 161 888976 1255 63608340
Myelodysplastic syndrome 196.93 13.74 67 889070 27512 63582083
Joint injury 196.89 13.74 730 888407 22217 63587378
Injection site papule 196.81 13.74 130 889007 704 63608891
Transient ischaemic attack 195.51 13.74 192 888945 43990 63565605
Intestinal obstruction 195.12 13.74 130 889007 36156 63573439
White blood cell count increased 193.99 13.74 385 888752 65629 63543966
Myalgia 191.32 13.74 1339 887798 157278 63452317
Shock haemorrhagic 190.08 13.74 10 889127 16781 63592814
Ill-defined disorder 189.85 13.74 1147 887990 42905 63566690
Blood sodium decreased 188.48 13.74 85 889052 29397 63580198
Circumstance or information capable of leading to medication error 187.63 13.74 231 888906 3109 63606486
Ataxia 187.40 13.74 38 889099 22046 63587549
Chest discomfort 186.17 13.74 894 888243 115212 63494383
Myocardial ischaemia 185.27 13.74 46 889091 23205 63586390
Hepatic enzyme increased 185.03 13.74 2664 886473 127279 63482316
Acute coronary syndrome 184.48 13.74 24 889113 19286 63590309
Muscle rigidity 184.26 13.74 15 889122 17458 63592137
Red blood cell count decreased 183.85 13.74 238 888899 48148 63561447
Product prescribing error 183.47 13.74 131 889006 35138 63574457
Rash 183.26 13.74 7897 881240 450652 63158943
Furuncle 183.22 13.74 323 888814 6110 63603485
Abdominal discomfort 183 13.74 3530 885607 178792 63430803
Device dislocation 182.74 13.74 35 889102 21143 63588452
Sudden death 182.62 13.74 29 889108 20067 63589528
Scratch 182.48 13.74 324 888813 6165 63603430
Nephropathy toxic 182.04 13.74 16 889121 17498 63592097
Haemodialysis 181.93 13.74 14 889123 17063 63592532
Erythema 181.72 13.74 3604 885533 183466 63426129
Wheezing 180.78 13.74 541 888596 80038 63529557
Atrial flutter 180.62 13.74 26 889111 19354 63590241
Left ventricular dysfunction 180.33 13.74 14 889123 16940 63592655
Walking aid user 179.71 13.74 316 888821 5965 63603630
Respiratory rate increased 179.49 13.74 21 889116 18310 63591285
Treatment noncompliance 178.88 13.74 201 888936 43281 63566314
Antibiotic therapy 178.36 13.74 118 889019 641 63608954
Device failure 178.15 13.74 298 888839 5394 63604201
Mania 177.39 13.74 12 889125 16274 63593321
Product quality issue 176.75 13.74 95 889042 29704 63579891
Neutrophil count increased 176.58 13.74 63 889074 25111 63584484
Thrombotic microangiopathy 176.46 13.74 14 889123 16641 63592954
Troponin increased 174.86 13.74 9 889128 15390 63594205
Speech disorder 174.23 13.74 248 888889 48193 63561402
Oliguria 173.89 13.74 6 889131 14570 63595025
Malnutrition 172.89 13.74 28 889109 19097 63590498
Acute myeloid leukaemia 172.74 13.74 81 889056 27382 63582213
Renal injury 172.14 13.74 10 889127 15419 63594176
Haemodynamic instability 171.62 13.74 8 889129 14904 63594691
Hypoalbuminaemia 171.20 13.74 21 889116 17653 63591942
Anaphylactic shock 170.84 13.74 103 889034 30225 63579370
Toxic skin eruption 170.42 13.74 30 889107 19254 63590341
Skin laceration 170.27 13.74 728 888409 23689 63585906
Anhedonia 169.54 13.74 4 889133 13702 63595893
Pallor 168.77 13.74 171 888966 38610 63570985
Device related infection 168.38 13.74 107 889030 30519 63579076
Mydriasis 167.61 13.74 11 889126 15301 63594294
Mitral valve incompetence 167.42 13.74 71 889066 25467 63584128
Anti-cyclic citrullinated peptide antibody positive 167.25 13.74 1214 887923 48348 63561247
Delusion 165.96 13.74 25 889112 17989 63591606
Supraventricular tachycardia 165.81 13.74 30 889107 18877 63590718
Myocarditis 165.70 13.74 20 889117 17023 63592572
Tricuspid valve incompetence 165.19 13.74 20 889117 16983 63592612
Drug dependence 163.96 13.74 131 889006 33181 63576414
Secretion discharge 163.65 13.74 447 888690 11517 63598078
Acute generalised exanthematous pustulosis 163.57 13.74 7 889130 14051 63595544
Transfusion 163.44 13.74 26 889111 17968 63591627
Immune system disorder 163.29 13.74 378 888759 8763 63600832
Exostosis 163.14 13.74 434 888703 11004 63598591
Prothrombin time prolonged 161.94 13.74 15 889122 15726 63593869
Gastroenteritis 161.71 13.74 105 889032 29606 63579989
Parkinsonism 161.33 13.74 9 889128 14364 63595231
Atelectasis 160.15 13.74 88 889049 27178 63582417
Hepatotoxicity 159.77 13.74 189 888948 39773 63569822
Myopathy 159.57 13.74 26 889111 17654 63591941
Musculoskeletal discomfort 159.55 13.74 541 888596 15736 63593859
Joint fluid drainage 158.65 13.74 80 889057 230 63609365
Cholelithiasis 157.77 13.74 239 888898 45267 63564328
Bronchospasm 157.75 13.74 51 889086 21631 63587964
Body temperature decreased 157.72 13.74 80 889057 25848 63583747
Glomerular filtration rate decreased 157.35 13.74 38 889099 19534 63590061
Urine output decreased 156.35 13.74 21 889116 16471 63593124
Atrioventricular block complete 155.94 13.74 11 889126 14407 63595188
Full blood count decreased 155.88 13.74 58 889079 22524 63587071
Chronic obstructive pulmonary disease 155.11 13.74 483 888654 70565 63539030
Hallucination, auditory 154.93 13.74 24 889113 16915 63592680
Osteonecrosis 154.68 13.74 99 889038 28130 63581465
Demyelination 154.66 13.74 311 888826 6523 63603072
Eye disorder 154.21 13.74 591 888546 18278 63591317
Anaphylactic reaction 154.03 13.74 461 888676 68203 63541392
Oesophagitis 153.66 13.74 53 889084 21577 63588018
Hypovolaemia 153.49 13.74 17 889120 15469 63594126
Klebsiella infection 153.25 13.74 7 889130 13274 63596321
Angina unstable 153.25 13.74 17 889120 15450 63594145
Inappropriate schedule of product administration 153.14 13.74 1945 887192 90341 63519254
Cytopenia 150.80 13.74 18 889119 15453 63594142
Spinal pain 149.76 13.74 448 888689 12173 63597422
Diverticulitis 149.28 13.74 978 888159 37640 63571955
Feeling hot 148.66 13.74 1109 888028 44554 63565041
Hepatitis cholestatic 148.64 13.74 4 889133 12151 63597444
Bronchopulmonary aspergillosis 147.78 13.74 40 889097 19045 63590550
Cardiac failure acute 147.58 13.74 24 889113 16320 63593275
Drug ineffective for unapproved indication 147.58 13.74 127 889010 31006 63578589
Injection site paraesthesia 147.40 13.74 92 889045 444 63609151
Discomfort 145.62 13.74 1731 887406 79147 63530448
Hypothyroidism 145.62 13.74 207 888930 40250 63569345
Aspiration 145.49 13.74 28 889109 16857 63592738
Hypernatraemia 145.47 13.74 5 889132 12184 63597411
Lipase increased 144.81 13.74 15 889122 14387 63595208
Drug resistance 144.68 13.74 162 888975 34940 63574655
Pemphigus 143.84 13.74 1373 887764 59328 63550267
Epistaxis 142.92 13.74 781 888356 97350 63512245
Hyperthermia 142.30 13.74 22 889115 15528 63594067
Haematotoxicity 141.94 13.74 9 889128 12887 63596708
Blood loss anaemia 140.90 13.74 14 889123 13878 63595717
Blood albumin decreased 140.70 13.74 57 889080 21016 63588579
Proteinuria 140.28 13.74 106 889031 27617 63581978
Blood potassium increased 139.79 13.74 93 889044 25887 63583708
COVID-19 pneumonia 138.80 13.74 29 889108 16475 63593120
Toothache 138.73 13.74 542 888595 16917 63592678
Subarachnoid haemorrhage 138.40 13.74 41 889096 18397 63591198
Depression 137.61 13.74 1741 887396 181550 63428045
Disturbance in attention 137.37 13.74 221 888916 40853 63568742
Paranoia 136.97 13.74 29 889108 16323 63593272
Peritonitis 136.77 13.74 88 889049 24935 63584660
Back disorder 136.40 13.74 373 888764 9617 63599978
Diabetes mellitus inadequate control 135.47 13.74 62 889075 21259 63588336
Blood pressure diastolic abnormal 135.20 13.74 7 889130 11910 63597685
Cardiomyopathy 134.77 13.74 92 889045 25264 63584331
Second primary malignancy 134.63 13.74 9 889128 12328 63597267
Pulseless electrical activity 134.15 13.74 11 889126 12728 63596867
Device use error 132.95 13.74 283 888854 6188 63603407
Interstitial lung disease 132.56 13.74 796 888341 96936 63512659
Increased upper airway secretion 131.49 13.74 200 888937 3327 63606268
Activated partial thromboplastin time prolonged 129.96 13.74 13 889124 12818 63596777
Gastroenteritis viral 129.77 13.74 578 888559 19151 63590444
Hypoaesthesia 129.70 13.74 2664 886473 136444 63473151
Lower gastrointestinal haemorrhage 129.21 13.74 19 889118 13920 63595675
Urosepsis 128.76 13.74 72 889065 22022 63587573
Ventricular extrasystoles 127.94 13.74 41 889096 17488 63592107
No adverse event 127.66 13.74 123 889014 28438 63581157
Enterocolitis 127.61 13.74 10 889127 12008 63597587
Heart rate irregular 127.32 13.74 114 889023 27299 63582296
Cytomegalovirus viraemia 127.30 13.74 5 889132 10823 63598772
Clostridium difficile infection 127.24 13.74 188 888949 35975 63573620
Drug level decreased 126.69 13.74 8 889129 11495 63598100
Hepatic cytolysis 126.03 13.74 21 889116 14028 63595567
Uveitis 125.99 13.74 424 888713 12284 63597311
Liver injury 125.72 13.74 136 889001 29796 63579799
Rash erythematous 125.29 13.74 1120 888017 47513 63562082
Mass 125.27 13.74 479 888658 14797 63594798
Failure to thrive 125.12 13.74 4 889133 10400 63599195
Metastases to bone 124.37 13.74 63 889074 20372 63589223
Blood magnesium decreased 124.26 13.74 21 889116 13884 63595711
Enterococcal infection 123.79 13.74 21 889116 13845 63595750
Haemolytic anaemia 123.63 13.74 34 889103 16019 63593576
Duodenal ulcer 122.15 13.74 25 889112 14410 63595185
Throat irritation 121.96 13.74 821 888316 31890 63577705
Full blood count abnormal 121.91 13.74 138 888999 29619 63579976
Infusion site pain 121.56 13.74 5 889132 10392 63599203
Nightmare 121.50 13.74 69 889068 20924 63588671
Respiratory acidosis 121.43 13.74 3 889134 9852 63599743
Dialysis 120.99 13.74 41 889096 16879 63592716
Hepatitis acute 120.14 13.74 20 889117 13369 63596226
Aplastic anaemia 120.12 13.74 23 889114 13897 63595698
Complication associated with device 119.83 13.74 30 889107 15050 63594545
Infusion related reaction 119.82 13.74 1572 887565 162895 63446700
Faeces discoloured 119.49 13.74 107 889030 25622 63583973
Arteriosclerosis coronary artery 119.39 13.74 33 889104 15496 63594099
Injection site laceration 119.35 13.74 50 889087 77 63609518
Rash papular 119.14 13.74 510 888627 16603 63592992
Ankylosing spondylitis 119.03 13.74 314 888823 7920 63601675
Pseudomonas infection 118.38 13.74 49 889088 17834 63591761
Blood lactic acid increased 118.35 13.74 6 889131 10395 63599200
Salivary hypersecretion 118.29 13.74 14 889123 12099 63597496
Rales 117.76 13.74 32 889105 15197 63594398
Macule 117.69 13.74 156 888981 2270 63607325
Wrist surgery 116.92 13.74 90 889047 643 63608952
Therapeutic response delayed 116.60 13.74 97 889040 785 63608810
Fine motor skill dysfunction 116.23 13.74 222 888915 4477 63605118
Granulocytopenia 115.77 13.74 7 889130 10433 63599162
Acute pulmonary oedema 115.23 13.74 19 889118 12790 63596805
Pathogen resistance 114.20 13.74 18 889119 12525 63597070
Meniscus injury 114.13 13.74 252 888885 5655 63603940
Anal incontinence 113.68 13.74 34 889103 15162 63594433
Bundle branch block right 113.52 13.74 7 889130 10262 63599333
Hepatitis 113.42 13.74 291 888846 45291 63564304
Tardive dyskinesia 112.31 13.74 3 889134 9175 63600420
Rheumatoid factor increased 112.04 13.74 117 889020 1299 63608296
Flatulence 111.82 13.74 200 888937 35466 63574129
Tooth disorder 111.39 13.74 606 888531 21796 63587799
Hyperthyroidism 110.71 13.74 56 889081 18123 63591472
Erythema multiforme 110.62 13.74 39 889098 15662 63593933
Toxic encephalopathy 110.62 13.74 6 889131 9809 63599786
Hydronephrosis 110.51 13.74 29 889108 14096 63595499
Substance abuse 110.24 13.74 4 889133 9288 63600307
Incorrect disposal of product 109.97 13.74 92 889045 751 63608844
Hypoacusis 109.84 13.74 671 888466 25196 63584399
Arthrodesis 109.78 13.74 139 888998 1928 63607667
Fatigue 109.16 13.74 11849 877288 736881 62872714
Pustular psoriasis 108.91 13.74 202 888935 3981 63605614
Cyst 108.57 13.74 389 888748 11638 63597957
Hypovolaemic shock 107.73 13.74 9 889128 10257 63599338
Ecchymosis 107.42 13.74 30 889107 13992 63595603
Glossodynia 107.08 13.74 1363 887774 63333 63546262
Lung infiltration 106.81 13.74 79 889058 20810 63588785
Polyuria 106.77 13.74 22 889115 12621 63596974
Laryngitis 106.68 13.74 365 888772 10666 63598929
Aspergillus infection 106.62 13.74 46 889091 16333 63593262
Kidney infection 106.52 13.74 508 888629 17330 63592265
Pulmonary haemorrhage 106.28 13.74 25 889112 13084 63596511
Urticaria 106.15 13.74 2721 886416 144596 63464999
Abdominal pain lower 106.01 13.74 125 889012 26344 63583251
End stage renal disease 105.09 13.74 11 889126 10464 63599131
Graft versus host disease 104.99 13.74 30 889107 13783 63595812
Ankle operation 104.89 13.74 97 889040 917 63608678
Injury 104.46 13.74 407 888730 55585 63554010
Apnoea 104.42 13.74 11 889126 10411 63599184
Pneumothorax 103.62 13.74 109 889028 24189 63585406
Influenza like illness 103.43 13.74 1303 887834 60399 63549196
Upper respiratory tract congestion 103.14 13.74 141 888996 2117 63607478
Irritability 103.12 13.74 220 888917 36526 63573069
Hypertensive crisis 102.74 13.74 62 889075 18186 63591409
Arteriosclerosis 102.71 13.74 45 889092 15832 63593763
Hyperlipidaemia 102.63 13.74 99 889038 22877 63586718
Cataract operation 101.87 13.74 186 888951 3620 63605975
Hyperuricaemia 101.48 13.74 11 889126 10180 63599415
Asphyxia 101.46 13.74 8 889129 9558 63600037
Eosinophil count increased 101.25 13.74 34 889103 14078 63595517
Faecaloma 100.80 13.74 9 889128 9719 63599876
Hip surgery 100.47 13.74 146 888991 2327 63607268
Chromaturia 100.33 13.74 98 889039 22513 63587082
Metastases to liver 100.31 13.74 109 889028 23832 63585763
Intestinal ischaemia 99.83 13.74 19 889118 11530 63598065
Skin mass 99.70 13.74 268 888869 6838 63602757
Hepatic necrosis 99.31 13.74 4 889133 8469 63601126
Viral upper respiratory tract infection 98.79 13.74 293 888844 7922 63601673
Colitis ischaemic 98.57 13.74 31 889106 13383 63596212
Cholecystitis 98.17 13.74 76 889061 19560 63590035
Thrombosis 98.09 13.74 571 888566 70071 63539524
Hypertriglyceridaemia 97.78 13.74 18 889119 11187 63598408
Gait inability 97.74 13.74 953 888184 41415 63568180
Gallbladder operation 97.52 13.74 119 889018 1586 63608009
Nail disorder 97.52 13.74 301 888836 8323 63601272
Pemphigoid 97.24 13.74 29 889108 12957 63596638
Immune thrombocytopenia 96.99 13.74 43 889094 15023 63594572
Wound 96.83 13.74 1537 887600 74940 63534655
Neck surgery 96.27 13.74 111 889026 1388 63608207
Pulse absent 96.25 13.74 7 889130 8939 63600656
Carpal tunnel decompression 96.23 13.74 69 889068 436 63609159
Haemophagocytic lymphohistiocytosis 96.14 13.74 62 889075 17547 63592048
Haemorrhagic stroke 95.95 13.74 12 889125 9939 63599656
Polyneuropathy 95.71 13.74 80 889057 19814 63589781
Peripheral sensory neuropathy 95.67 13.74 20 889117 11358 63598237
Diastolic dysfunction 95.33 13.74 7 889130 8868 63600727
Skin fissures 95.32 13.74 336 888801 9970 63599625
Cholecystitis chronic 95.14 13.74 9 889128 9278 63600317
Amylase increased 95.06 13.74 11 889126 9674 63599921
Psychomotor hyperactivity 95.01 13.74 40 889097 14411 63595184
Animal bite 94.93 13.74 133 889004 2046 63607549
Peritonitis bacterial 94.70 13.74 8 889129 9035 63600560
Tooth abscess 94.68 13.74 410 888727 13416 63596179
Electrocardiogram abnormal 94.10 13.74 34 889103 13447 63596148
Onychomycosis 94.06 13.74 216 888921 4980 63604615
Ventricular hypokinesia 93.38 13.74 3 889134 7766 63601829
Atrioventricular block 93.37 13.74 25 889112 11990 63597605
Schizophrenia 93.15 13.74 20 889117 11148 63598447
Tooth extraction 92.25 13.74 317 888820 9284 63600311
Ankle deformity 92.21 13.74 75 889062 586 63609009
Iridocyclitis 92.09 13.74 157 888980 2888 63606707
Device difficult to use 91.96 13.74 321 888816 9477 63600118
Blood triglycerides increased 91.83 13.74 75 889062 18791 63590804
Cholecystitis acute 91.43 13.74 22 889115 11338 63598257
Rotator cuff repair 91.27 13.74 108 889029 1391 63608204
Petechiae 90.72 13.74 74 889063 18552 63591043
Sarcoidosis 90.50 13.74 236 888901 5910 63603685
Tooth fracture 90.40 13.74 322 888815 9605 63599990
Hepatomegaly 90.06 13.74 61 889076 16821 63592774
Acute graft versus host disease 89.96 13.74 10 889127 9074 63600521
Insurance issue 89.84 13.74 149 888988 2677 63606918
Intervertebral disc protrusion 89.71 13.74 530 888607 19661 63589934
Limb deformity 89.64 13.74 164 888973 3197 63606398
Haemolysis 89.60 13.74 21 889116 11018 63598577
Hemiplegia 89.47 13.74 32 889105 12736 63596859
Taste disorder 89.45 13.74 12 889125 9421 63600174
Bone disorder 89.24 13.74 462 888675 16297 63593298
Haemorrhoids 89.18 13.74 120 889017 23881 63585714
Cerebral ischaemia 89.12 13.74 15 889122 9947 63599648
Drug level below therapeutic 88.22 13.74 3 889134 7381 63602214
Asthma 87.43 13.74 864 888273 94361 63515234
Jaundice cholestatic 87.25 13.74 9 889128 8661 63600934
Metabolic encephalopathy 87.15 13.74 6 889131 8019 63601576
Cardiac failure chronic 86.94 13.74 11 889126 9030 63600565
COVID-19 86.51 13.74 534 888603 64606 63544989
Memory impairment 86.22 13.74 1660 887477 84022 63525573
Elbow operation 86.22 13.74 51 889086 219 63609376
Oral surgery 85.95 13.74 85 889052 880 63608715
Rheumatoid factor negative 85.93 13.74 90 889047 1003 63608592
Endodontic procedure 85.57 13.74 131 889006 2192 63607403
Frequent bowel movements 85.16 13.74 76 889061 18229 63591366
Blood pressure systolic abnormal 84.58 13.74 17 889120 9925 63599670
Metastases to central nervous system 84.50 13.74 43 889094 13869 63595726
Blood pressure systolic decreased 84.16 13.74 11 889126 8809 63600786
Ileus paralytic 84.00 13.74 9 889128 8406 63601189
Product complaint 83.70 13.74 30 889107 11924 63597671
Bundle branch block left 83.62 13.74 18 889119 10016 63599579
Left ventricular hypertrophy 83.54 13.74 15 889122 9491 63600104
Azotaemia 83.28 13.74 5 889132 7497 63602098
Rotator cuff syndrome 82.89 13.74 359 888778 11748 63597847
Dysgeusia 82.72 13.74 350 888787 46697 63562898
Toe operation 82.62 13.74 63 889074 443 63609152
Prescribed underdose 82.37 13.74 76 889061 17939 63591656
Injection site hypoaesthesia 82.32 13.74 58 889079 355 63609240
Bradyphrenia 82.32 13.74 15 889122 9391 63600204
Hypertransaminasaemia 82.30 13.74 4 889133 7187 63602408
Purpura 82.17 13.74 70 889067 17176 63592419
Burning sensation 82.05 13.74 1046 888091 48618 63560977
Systemic inflammatory response syndrome 82.03 13.74 20 889117 10215 63599380
Decubitus ulcer 81.79 13.74 41 889096 13338 63596257
Hypoxic-ischaemic encephalopathy 81.78 13.74 4 889133 7148 63602447
Infusion site erythema 81.39 13.74 3 889134 6870 63602725
Dental operation 81.38 13.74 82 889055 870 63608725
Forced expiratory volume decreased 81.31 13.74 3 889134 6864 63602731
Ketoacidosis 81.26 13.74 3 889134 6860 63602735
Coma scale abnormal 81.07 13.74 7 889130 7767 63601828
Head injury 80.68 13.74 211 888926 32631 63576964
Stress cardiomyopathy 80.50 13.74 15 889122 9242 63600353
Pulmonary alveolar haemorrhage 80.08 13.74 18 889119 9720 63599875
Hypercapnia 80.04 13.74 7 889130 7687 63601908
Gastric ulcer 79.94 13.74 187 888950 30047 63579548
Carpal tunnel syndrome 79.93 13.74 430 888707 15398 63594197
Scab 79.90 13.74 290 888847 8732 63600863
Bronchitis chronic 79.68 13.74 171 888966 3761 63605834
Hyperhidrosis 79.65 13.74 1226 887911 123694 63485901
Eye operation 79.57 13.74 110 889027 1670 63607925
Eye infection 79.40 13.74 295 888842 8986 63600609
Prescribed overdose 79.31 13.74 98 889039 20233 63589362
Cerebral haematoma 79.12 13.74 5 889132 7180 63602415
Skin exfoliation 78.73 13.74 956 888181 43929 63565666
Chills 78.66 13.74 1374 887763 135890 63473705
Skin ulcer 78.61 13.74 940 888197 43034 63566561
Vulvovaginal mycotic infection 78.42 13.74 162 888975 3466 63606129
Gastritis erosive 78.38 13.74 18 889119 9577 63600018
Cystitis haemorrhagic 78.18 13.74 9 889128 7947 63601648
Pyelonephritis 77.58 13.74 74 889063 17192 63592403
Myositis 77.39 13.74 67 889070 16310 63593285
Apathy 77.27 13.74 29 889108 11203 63598392
Apparent death 77.04 13.74 135 889002 2541 63607054
Enteritis 76.91 13.74 35 889102 12042 63597553
Skin disorder 76.78 13.74 648 888489 27032 63582563
Dermatitis bullous 76.66 13.74 35 889102 12019 63597576
Cardiac disorder 76.51 13.74 453 888684 55363 63554232
Device occlusion 76.33 13.74 21 889116 9892 63599703
Ageusia 76.28 13.74 48 889089 13765 63595830
Pneumocystis jirovecii pneumonia 76.25 13.74 167 888970 27467 63582128
Mental disorder 76.16 13.74 156 888981 26289 63583306
Surgical failure 76.08 13.74 73 889064 726 63608869
Poor venous access 75.99 13.74 38 889099 12379 63597216
Cachexia 75.87 13.74 17 889120 9200 63600395
Coronary artery stenosis 75.79 13.74 30 889107 11218 63598377
Gastric haemorrhage 75.62 13.74 46 889091 13435 63596160
Lower respiratory tract infection 75.44 13.74 1772 887365 92842 63516753
Hypogammaglobulinaemia 75.32 13.74 24 889113 10275 63599320
Partial seizures 75.07 13.74 7 889130 7300 63602295
International normalised ratio decreased 74.64 13.74 8 889129 7470 63602125
Device dispensing error 74.61 13.74 35 889102 81 63609514
Infusion site extravasation 74.57 13.74 5 889132 6832 63602763
Elbow deformity 74.46 13.74 90 889047 1187 63608408
Paranasal sinus discomfort 74.31 13.74 146 888991 3009 63606586
Concomitant disease aggravated 74.21 13.74 33 889104 11509 63598086
Latent tuberculosis 74.13 13.74 135 889002 2622 63606973
Aplasia pure red cell 74.02 13.74 6 889131 7008 63602587
Injection site exfoliation 73.96 13.74 37 889100 104 63609491
Metastases to lung 73.90 13.74 61 889076 15203 63594392
Incontinence 73.89 13.74 37 889100 12044 63597551
Drug tolerance decreased 73.41 13.74 238 888899 6760 63602835
Lung consolidation 73.26 13.74 10 889127 7748 63601847
Nocturia 73.25 13.74 31 889106 11134 63598461
Hyperreflexia 73.03 13.74 7 889130 7141 63602454
Rheumatoid arthritis 73.03 13.74 2863 886274 161431 63448164
Upper-airway cough syndrome 72.74 13.74 276 888861 8494 63601101
Injection site dryness 72.46 13.74 43 889094 186 63609409
Tenderness 71.88 13.74 490 888647 19112 63590483
Weight increased 71.69 13.74 2317 886820 211031 63398564
General symptom 71.54 13.74 118 889019 2110 63607485
Oral mucosal exfoliation 71.24 13.74 92 889045 1303 63608292
Iron deficiency anaemia 71.11 13.74 120 889017 21769 63587826
Premature delivery 71.06 13.74 91 889046 18498 63591097
Cholangitis 70.85 13.74 30 889107 10772 63598823
Protein urine present 70.81 13.74 18 889119 8938 63600657
Immune reconstitution inflammatory syndrome 70.72 13.74 42 889095 12428 63597167
Physical disability 70.67 13.74 119 889018 2166 63607429
Hypotonia 70.62 13.74 33 889104 11179 63598416
Lymphoma 70.58 13.74 379 888758 13562 63596033
Dry eye 70.53 13.74 660 888477 28359 63581236
Swollen tongue 70.50 13.74 246 888891 34708 63574887
Hallucinations, mixed 70.46 13.74 3 889134 6049 63603546
Sciatica 70.45 13.74 500 888637 19764 63589831
Wrist deformity 69.85 13.74 104 889033 1696 63607899
Nerve compression 69.65 13.74 244 888893 7217 63602378
Cardiac tamponade 69.37 13.74 14 889123 8150 63601445
Sleep apnoea syndrome 69.28 13.74 197 888940 29635 63579960
Ischaemic cardiomyopathy 69.07 13.74 7 889130 6831 63602764
Blood chloride decreased 68.99 13.74 10 889127 7406 63602189
Vascular device infection 68.96 13.74 4 889133 6176 63603419
Product substitution issue 68.73 13.74 87 889050 17774 63591821
Synovial cyst 68.48 13.74 248 888889 7459 63602136
Arthropod sting 68.28 13.74 74 889063 860 63608735
Lip swelling 68.16 13.74 219 888918 31688 63577907
Pneumonia fungal 67.99 13.74 19 889118 8858 63600737
Nephropathy 67.97 13.74 16 889121 8370 63601225
Dyspnoea at rest 67.96 13.74 5 889132 6324 63603271
Injection site coldness 67.94 13.74 32 889105 75 63609520
Blood culture positive 67.89 13.74 13 889124 7855 63601740
Injection site oedema 67.73 13.74 79 889058 1001 63608594
Clonus 67.48 13.74 4 889133 6063 63603532
Hepatitis fulminant 67.24 13.74 5 889132 6269 63603326
Tachyarrhythmia 66.94 13.74 4 889133 6022 63603573
Hypoventilation 66.68 13.74 4 889133 6002 63603593
Splenomegaly 66.53 13.74 90 889047 17871 63591724
Oral herpes 65.97 13.74 527 888610 21625 63587970
Vertigo 65.88 13.74 509 888628 58502 63551093
Irritable bowel syndrome 65.57 13.74 796 888341 36573 63573022
Embolism 65.55 13.74 44 889093 12191 63597404
Dysuria 65.54 13.74 327 888810 41730 63567865
Hypertonia 65.14 13.74 6 889131 6319 63603276
Vision blurred 65.09 13.74 865 888272 89451 63520144
Ischaemia 65.02 13.74 11 889126 7267 63602328
Deformity 65.01 13.74 213 888924 6084 63603511
Ventricular hypertrophy 64.97 13.74 7 889130 6509 63603086
Hospice care 64.95 13.74 13 889124 7612 63601983
Dental implantation 64.90 13.74 51 889086 377 63609218
Brain injury 64.84 13.74 28 889109 9937 63599658
Muscular weakness 64.48 13.74 1302 887835 126036 63483559
BK virus infection 64.48 13.74 12 889125 7400 63602195
Erectile dysfunction 64.24 13.74 48 889089 12579 63597016
Diplopia 64.20 13.74 174 888963 26591 63583004
Orthopnoea 63.82 13.74 23 889114 9111 63600484
Panniculitis 63.66 13.74 267 888870 8612 63600983
Post procedural haemorrhage 63.57 13.74 47 889090 12384 63597211
Device power source issue 63.53 13.74 66 889071 728 63608867
Renal tubular disorder 63.52 13.74 5 889132 5982 63603613
Muscle haemorrhage 63.36 13.74 4 889133 5749 63603846
Wheelchair user 63.34 13.74 174 888963 4498 63605097
Nystagmus 63.08 13.74 23 889114 9045 63600550
Intestinal perforation 62.74 13.74 71 889066 15242 63594353
Ear congestion 62.59 13.74 109 889028 2041 63607554
Joint surgery 62.39 13.74 42 889095 236 63609359
SLE arthritis 62.27 13.74 55 889082 487 63609108
Peripheral ischaemia 62.21 13.74 19 889118 8359 63601236
Muscle injury 62.12 13.74 597 888540 25840 63583755
Non-cardiac chest pain 62.12 13.74 21 889116 8659 63600936
Wrong product administered 62.04 13.74 15 889122 7705 63601890
Dyspepsia 62.04 13.74 758 888379 79554 63530041
Metabolic disorder 61.77 13.74 15 889122 7682 63601913
Bone swelling 61.74 13.74 80 889057 1137 63608458
Tuberculosis 61.68 13.74 348 888789 12690 63596905
Post procedural infection 61.49 13.74 279 888858 9318 63600277
Blood pressure diastolic increased 61.28 13.74 36 889101 10716 63598879
Guttate psoriasis 61.28 13.74 48 889089 353 63609242
Aplasia 61.04 13.74 11 889126 6942 63602653
Brain natriuretic peptide increased 61.01 13.74 15 889122 7618 63601977
Left ventricular failure 60.87 13.74 20 889117 8397 63601198
Cytomegalovirus infection reactivation 60.53 13.74 5 889132 5751 63603844
Granuloma skin 60.51 13.74 203 888934 5871 63603724
Infection susceptibility increased 60.43 13.74 123 889014 2603 63606992
Blood parathyroid hormone decreased 60.42 13.74 231 888906 7135 63602460
Hiccups 60.41 13.74 20 889117 8356 63601239
Nail pitting 60.39 13.74 42 889095 251 63609344
Joint dislocation 60.31 13.74 315 888822 11150 63598445
Enthesopathy 60.12 13.74 278 888859 9360 63600235
Progressive multifocal leukoencephalopathy 60.11 13.74 99 889038 18133 63591462
Duodenal ulcer haemorrhage 60.09 13.74 8 889129 6317 63603278
Dermatitis exfoliative 59.94 13.74 34 889103 10318 63599277
Blood phosphorus decreased 59.87 13.74 5 889132 5700 63603895
Occult blood positive 59.61 13.74 8 889129 6279 63603316
Pneumatosis intestinalis 59.55 13.74 3 889134 5226 63604369
Ammonia increased 59.21 13.74 12 889125 6965 63602630
Nerve injury 58.98 13.74 236 888901 7449 63602146
Portal hypertension 58.76 13.74 8 889129 6211 63603384
Induration 58.73 13.74 92 889045 1572 63608023
Fungal infection 58.54 13.74 726 888411 33525 63576070
Cardiovascular disorder 58.40 13.74 80 889057 15801 63593794
Endophthalmitis 58.29 13.74 4 889133 5361 63604234
Odynophagia 58.26 13.74 30 889107 9611 63599984
Pneumonia bacterial 58.10 13.74 73 889064 14962 63594633
Sensitivity to weather change 57.93 13.74 214 888923 6500 63603095
Sickle cell anaemia with crisis 57.86 13.74 4 889133 5328 63604267
Large intestine perforation 57.83 13.74 53 889084 12551 63597044
Platelet count increased 57.57 13.74 106 889031 18590 63591005
Red cell distribution width increased 57.38 13.74 51 889086 12258 63597337
Protein total decreased 57.14 13.74 19 889118 7917 63601678
Musculoskeletal deformity 57.13 13.74 57 889080 597 63608998
Middle insomnia 56.92 13.74 56 889081 12821 63596774
Orthosis user 56.90 13.74 24 889113 38 63609557
Infusion site swelling 56.78 13.74 5 889132 5460 63604135
Glycosylated haemoglobin increased 56.62 13.74 83 889054 15936 63593659
Dental care 56.45 13.74 60 889077 681 63608914
Injection site scar 56.36 13.74 59 889078 657 63608938
Knee deformity 56.25 13.74 66 889071 842 63608753
Venous thrombosis 56.22 13.74 10 889127 6371 63603224
Aortic valve incompetence 56.16 13.74 22 889115 8279 63601316
Escherichia bacteraemia 55.98 13.74 5 889132 5398 63604197
Ligament rupture 55.71 13.74 114 889023 2422 63607173
Candida infection 55.69 13.74 233 888904 31186 63578409
Onychomadesis 55.68 13.74 123 889014 2761 63606834
Appendicitis 55.50 13.74 63 889074 13506 63596089
Intracranial pressure increased 55.35 13.74 14 889123 6975 63602620
Tendon operation 55.32 13.74 39 889098 239 63609356
Incorrect product administration duration 55.15 13.74 33 889104 9725 63599870
Electrocardiogram T wave inversion 55.13 13.74 3 889134 4891 63604704
Nasal discharge discolouration 55.12 13.74 92 889045 1662 63607933
Cerebral atrophy 55.04 13.74 16 889121 7269 63602326
Systemic candida 55.03 13.74 5 889132 5324 63604271
Respiratory syncytial virus infection 54.84 13.74 16 889121 7252 63602343
Bunion operation 54.80 13.74 61 889076 732 63608863
Hiatus hernia 54.74 13.74 121 889016 19836 63589759
Gastrointestinal disorder 54.70 13.74 1622 887515 88087 63521508
Catheter site infection 54.56 13.74 7 889130 5686 63603909
Hyperlactacidaemia 54.47 13.74 3 889134 4841 63604754
Thrombosis in device 54.47 13.74 4 889133 5067 63604528
Gastric ulcer haemorrhage 54.41 13.74 22 889115 8121 63601474
Dyslipidaemia 54.02 13.74 30 889107 9212 63600383
Embolic stroke 54.01 13.74 13 889124 6698 63602897
Device defective 53.96 13.74 77 889060 1206 63608389
Blood chloride increased 53.93 13.74 3 889134 4800 63604795
Folliculitis 53.79 13.74 643 888494 29434 63580161
Aortic arteriosclerosis 53.66 13.74 18 889119 7458 63602137
Papule 53.62 13.74 201 888936 6149 63603446
Normal newborn 53.61 13.74 7 889130 5610 63603985
Sinus node dysfunction 53.45 13.74 14 889123 6814 63602781
Electroencephalogram abnormal 53.41 13.74 5 889132 5198 63604397
Hysterectomy 53.39 13.74 173 888964 4912 63604683
Hydrocephalus 53.23 13.74 19 889118 7572 63602023
Benign prostatic hyperplasia 53.21 13.74 30 889107 9135 63600460
Serum ferritin increased 53.21 13.74 25 889112 8443 63601152
Body temperature abnormal 53.16 13.74 86 889051 1512 63608083
Intervertebral disc operation 53.13 13.74 58 889079 680 63608915
Necrosis 53.10 13.74 23 889114 8148 63601447
Pulmonary function test decreased 53.02 13.74 12 889125 6449 63603146
Pseudomonal sepsis 53.01 13.74 5 889132 5167 63604428
Foetal death 52.89 13.74 9 889128 5921 63603674
Retinal haemorrhage 52.77 13.74 18 889119 7380 63602215
Supraventricular extrasystoles 52.71 13.74 9 889128 5906 63603689
Euphoric mood 52.59 13.74 13 889124 6578 63603017
Genital haemorrhage 52.42 13.74 7 889130 5515 63604080
Pericarditis 52.35 13.74 1179 887958 61337 63548258
Rash macular 52.31 13.74 528 888609 23157 63586438
Blood thyroid stimulating hormone increased 52.26 13.74 20 889117 7634 63601961
Abortion induced 52.15 13.74 12 889125 6376 63603219
Mucormycosis 52.12 13.74 18 889119 7323 63602272
Stridor 51.91 13.74 4 889133 4870 63604725
Staphylococcal bacteraemia 51.87 13.74 40 889097 10315 63599280
Mental impairment 51.81 13.74 91 889046 16252 63593343
Malignant melanoma 51.73 13.74 331 888806 12633 63596962
Product administered at inappropriate site 51.64 13.74 125 889012 2985 63606610
Alcohol abuse 51.62 13.74 4 889133 4848 63604747
Dementia 51.33 13.74 133 889004 20633 63588962
Diverticulum intestinal 51.31 13.74 19 889118 7401 63602194
Dislocation of vertebra 51.27 13.74 125 889012 2999 63606596
Proctalgia 51.20 13.74 20 889117 7539 63602056
Scleritis 51.17 13.74 121 889016 2845 63606750
Eye movement disorder 50.88 13.74 17 889120 7062 63602533
Chronic graft versus host disease 50.82 13.74 12 889125 6264 63603331
Lip oedema 50.66 13.74 6 889131 5183 63604412
Neoplasm malignant 50.57 13.74 542 888595 24146 63585449
Nocardiosis 50.52 13.74 4 889133 4763 63604832
Drug screen positive 50.43 13.74 9 889128 5720 63603875
Stress at work 50.16 13.74 65 889072 924 63608671
Breath sounds abnormal 50.14 13.74 52 889085 11617 63597978
Helicobacter infection 50.06 13.74 775 888362 37587 63572008
Neutrophilia 50.03 13.74 15 889122 6679 63602916
Nervousness 49.88 13.74 625 888512 28931 63580664
Fistula 49.79 13.74 37 889100 9724 63599871
Foetal exposure during pregnancy 49.63 13.74 3 889134 4473 63605122
Laryngeal oedema 49.55 13.74 18 889119 7095 63602500
Catheter site pain 49.45 13.74 3 889134 4459 63605136
Sleep disorder 49.35 13.74 1124 888013 58585 63551010
Thrombotic thrombocytopenic purpura 49.33 13.74 11 889126 5973 63603622
Lower limb fracture 49.31 13.74 338 888799 13207 63596388
Major depression 49.23 13.74 23 889114 7793 63601802
Neutrophil percentage increased 49.23 13.74 3 889134 4442 63605153
Product administration error 48.99 13.74 205 888932 27438 63582157
Gastrointestinal perforation 48.89 13.74 8 889129 5416 63604179
Pulmonary fibrosis 48.80 13.74 628 888509 29250 63580345
Anaemia macrocytic 48.61 13.74 3 889134 4395 63605200
Affect lability 48.61 13.74 32 889105 8958 63600637
Breast cancer female 48.60 13.74 168 888969 4935 63604660
Colitis ulcerative 48.53 13.74 159 888978 22869 63586726
Escherichia infection 48.50 13.74 84 889053 15084 63594511
Oxygen consumption increased 48.12 13.74 4 889133 4577 63605018
Oesophageal ulcer 48.11 13.74 13 889124 6197 63603398
Eosinophilic pneumonia 48.06 13.74 4 889133 4573 63605022
Methaemoglobinaemia 47.96 13.74 3 889134 4345 63605250
Incoherent 47.93 13.74 19 889118 7099 63602496
Cystitis 47.88 13.74 841 888296 41834 63567761
Gynaecomastia 47.74 13.74 12 889125 6004 63603591
Coordination abnormal 47.73 13.74 83 889054 14881 63594714
Cytomegalovirus test positive 47.71 13.74 7 889130 5137 63604458
Injection site pustule 47.70 13.74 23 889114 58 63609537
Drooling 47.60 13.74 8 889129 5311 63604284
Blood phosphorus increased 47.60 13.74 6 889131 4940 63604655
Carotid artery stenosis 47.55 13.74 25 889112 7916 63601679
Central nervous system lesion 47.40 13.74 56 889081 11793 63597802
Abdominal wall haematoma 47.39 13.74 3 889134 4302 63605293
Injection site discharge 47.37 13.74 43 889094 396 63609199
Diabetes insipidus 47.34 13.74 4 889133 4517 63605078
Blood creatine increased 47.30 13.74 27 889110 8165 63601430
Cytomegalovirus chorioretinitis 47.18 13.74 6 889131 4906 63604689
Product distribution issue 47.14 13.74 58 889079 780 63608815
Transplant rejection 47.01 13.74 405 888732 16996 63592599
Animal scratch 46.86 13.74 63 889074 930 63608665
Application site erythema 46.85 13.74 5 889132 4684 63604911
Skin swelling 46.81 13.74 112 889025 2654 63606941
Hangnail 46.78 13.74 15 889122 3 63609592
Alcohol poisoning 46.74 13.74 3 889134 4252 63605343
Head discomfort 46.52 13.74 301 888836 11533 63598062
Spinal stenosis 46.27 13.74 340 888797 13591 63596004
Blister 46.17 13.74 1452 887685 79515 63530080
Joint laxity 46.16 13.74 100 889037 2214 63607381
Obsessive-compulsive disorder 46.00 13.74 6 889131 4812 63604783
Femoral neck fracture 45.90 13.74 32 889105 8692 63600903
Portal vein thrombosis 45.81 13.74 7 889130 4984 63604611
Blood glucose decreased 45.78 13.74 164 888973 22959 63586636
Migraine 45.78 13.74 1160 887977 61517 63548078
Laryngeal pain 45.57 13.74 11 889126 5657 63603938
Atlantoaxial instability 45.51 13.74 36 889101 269 63609326
Glaucoma 45.49 13.74 383 888754 15965 63593630
Iron deficiency 45.39 13.74 21 889116 7156 63602439
Bone cyst 45.04 13.74 96 889041 2101 63607494
Acute graft versus host disease in skin 45.02 13.74 19 889118 6836 63602759
Escherichia urinary tract infection 44.91 13.74 60 889077 11977 63597618
Periorbital oedema 44.90 13.74 23 889114 7391 63602204
Ventricular dysfunction 44.86 13.74 9 889128 5261 63604334
Normochromic normocytic anaemia 44.82 13.74 18 889119 6672 63602923
Tenosynovitis 44.71 13.74 298 888839 11535 63598060
Personality disorder 44.65 13.74 6 889131 4705 63604890
Hyperpyrexia 44.64 13.74 8 889129 5069 63604526
Congestive cardiomyopathy 44.56 13.74 46 889091 10298 63599297
Lupus-like syndrome 44.51 13.74 239 888898 8552 63601043
Atypical femur fracture 44.49 13.74 6 889131 4692 63604903
Limb injury 44.47 13.74 508 888629 22997 63586598
Depressive symptom 44.39 13.74 5 889132 4491 63605104
Lyme disease 44.39 13.74 101 889036 2314 63607281
Multiple-drug resistance 44.37 13.74 17 889120 6485 63603110
Thyroid neoplasm 44.34 13.74 107 889030 2550 63607045
Logorrhoea 44.18 13.74 3 889134 4056 63605539
Blood pressure inadequately controlled 44.18 13.74 10 889127 5374 63604221
Hypoglycaemic coma 44.16 13.74 4 889133 4270 63605325
Petit mal epilepsy 44.09 13.74 8 889129 5024 63604571
Bedridden 44.04 13.74 264 888873 9845 63599750
Fibrin D dimer increased 44.03 13.74 19 889118 6746 63602849
Performance status decreased 43.94 13.74 10 889127 5354 63604241
Lymphocyte percentage decreased 43.88 13.74 6 889131 4643 63604952
Neurological decompensation 43.63 13.74 5 889132 4431 63605164
Renal cyst 43.58 13.74 66 889071 12504 63597091
International normalised ratio abnormal 43.55 13.74 8 889129 4980 63604615
Off label use 43.49 13.74 7871 881266 624935 62984660
Nephrolithiasis 43.48 13.74 845 888292 42838 63566757
Colonoscopy 43.41 13.74 81 889056 1604 63607991
Scar 43.37 13.74 325 888812 13073 63596522
Skin injury 43.36 13.74 92 889045 2007 63607588
Renal disorder 43.35 13.74 297 888840 35068 63574527
Osteoporosis 43.25 13.74 818 888319 41262 63568333
Breast cancer stage III 43.24 13.74 112 889025 2793 63606802
Bacterial test positive 43.21 13.74 19 889118 6671 63602924
Hernia repair 43.18 13.74 83 889054 1682 63607913
Hyperphosphataemia 43.16 13.74 3 889134 3978 63605617
Exposure to communicable disease 42.91 13.74 43 889094 453 63609142
Human antichimeric antibody positive 42.81 13.74 73 889064 1343 63608252
Persecutory delusion 42.67 13.74 4 889133 4154 63605441
Culture urine positive 42.58 13.74 4 889133 4147 63605448
Mineral metabolism disorder 42.58 13.74 35 889102 278 63609317
Spider vein 42.53 13.74 30 889107 184 63609411
Bone graft 42.50 13.74 48 889089 586 63609009
Pneumonia cytomegaloviral 42.41 13.74 5 889132 4334 63605261
Burn infection 42.39 13.74 16 889121 15 63609580
Autonomic nervous system imbalance 42.34 13.74 4 889133 4128 63605467
Cardiopulmonary failure 42.33 13.74 16 889121 6154 63603441
Exercise tolerance decreased 42.29 13.74 27 889110 7683 63601912
Duodenitis 42.21 13.74 20 889117 6721 63602874
Rhinovirus infection 42.17 13.74 16 889121 6140 63603455
Tenoplasty 42.12 13.74 18 889119 30 63609565
Clostridium test positive 42.12 13.74 4 889133 4111 63605484
Lacunar infarction 42.07 13.74 12 889125 5520 63604075
Refusal of treatment by patient 42.04 13.74 32 889105 8307 63601288
Personality change 42.02 13.74 34 889103 8559 63601036
Rhinitis allergic 42.02 13.74 30 889107 8048 63601547
Fluid intake reduced 41.99 13.74 10 889127 5190 63604405
Haemothorax 41.78 13.74 8 889129 4834 63604761
Red blood cells urine positive 41.75 13.74 6 889131 4472 63605123
Blood uric acid increased 41.57 13.74 31 889106 8132 63601463
Gastrointestinal necrosis 41.51 13.74 9 889128 4983 63604612
Spinal instability 41.51 13.74 37 889100 332 63609263
Weight fluctuation 41.47 13.74 32 889105 8250 63601345
Subileus 41.33 13.74 9 889128 4968 63604627
Arteriospasm coronary 41.29 13.74 12 889125 5453 63604142
Rash morbilliform 41.29 13.74 10 889127 5131 63604464
Somnambulism 41.29 13.74 10 889127 5131 63604464
Bilirubin conjugated increased 41.22 13.74 9 889128 4959 63604636
Thirst 41.05 13.74 83 889054 14054 63595541
Lipodystrophy acquired 40.99 13.74 4 889133 4023 63605572
Haemolytic uraemic syndrome 40.92 13.74 4 889133 4017 63605578
Paraesthesia oral 40.83 13.74 74 889063 13057 63596538
Intervertebral disc space narrowing 40.82 13.74 70 889067 1294 63608301
C-reactive protein increased 40.77 13.74 1648 887489 93261 63516334
Spinal disorder 40.73 13.74 232 888905 8490 63601105
Prostate infection 40.73 13.74 42 889095 459 63609136
Respiration abnormal 40.69 13.74 18 889119 6297 63603298
Pseudomembranous colitis 40.60 13.74 9 889128 4907 63604688
Inadequate analgesia 40.37 13.74 4 889133 3974 63605621
Cardiac operation 40.37 13.74 139 888998 4075 63605520
Leukoencephalopathy 40.17 13.74 23 889114 6944 63602651
Nasal ulcer 40.12 13.74 74 889063 1452 63608143
Hepatorenal syndrome 40.10 13.74 3 889134 3743 63605852
Intraventricular haemorrhage 40.06 13.74 5 889132 4148 63605447
Pathological fracture 39.99 13.74 39 889098 8966 63600629
Self-medication 39.96 13.74 5 889132 4140 63605455
Conjunctival haemorrhage 39.87 13.74 10 889127 5011 63604584
Staphylococcus test positive 39.81 13.74 14 889123 5631 63603964
Systemic infection 39.80 13.74 6 889131 4315 63605280
Spinal laminectomy 39.78 13.74 44 889093 524 63609071
Sacroiliitis 39.67 13.74 111 889026 2901 63606694
Night sweats 39.59 13.74 708 888429 35338 63574257
Depressed mood 39.37 13.74 368 888769 40644 63568951
Eye pruritus 39.25 13.74 304 888833 12355 63597240
Injection site anaesthesia 39.23 13.74 16 889121 22 63609573
Cyst removal 39.11 13.74 37 889100 361 63609234
Staphylococcal sepsis 38.95 13.74 74 889063 12825 63596770
Prostatic specific antigen increased 38.83 13.74 38 889099 8722 63600873
Faecal calprotectin increased 38.73 13.74 3 889134 3637 63605958
Sudden cardiac death 38.70 13.74 8 889129 4579 63605016
Compartment syndrome 38.69 13.74 6 889131 4226 63605369
Skin hyperpigmentation 38.68 13.74 21 889116 6530 63603065
Systemic lupus erythematosus rash 38.60 13.74 70 889067 1355 63608240
Haemarthrosis 38.57 13.74 12 889125 5217 63604378
Bacterial sepsis 38.39 13.74 28 889109 7429 63602166
Paralysis 38.19 13.74 63 889074 11532 63598063
Dermatitis acneiform 38.15 13.74 36 889101 8407 63601188
Accident 38.04 13.74 191 888946 6655 63602940
Infected bite 38.02 13.74 67 889070 1267 63608328
Cerebellar syndrome 37.93 13.74 11 889126 5005 63604590
Foot fracture 37.83 13.74 400 888737 17757 63591838
Areflexia 37.82 13.74 11 889126 4996 63604599
Menopause 37.78 13.74 77 889060 1631 63607964
Atrial tachycardia 37.68 13.74 3 889134 3556 63606039
Adenovirus infection 37.66 13.74 27 889110 7228 63602367
Duodenal ulcer perforation 37.65 13.74 679 888458 33946 63575649
Blood sodium increased 37.64 13.74 7 889130 4319 63605276
Phlebitis 37.64 13.74 31 889106 7735 63601860
Bradyarrhythmia 37.56 13.74 4 889133 3754 63605841
Retching 37.48 13.74 98 889039 15158 63594437
Nephrotic syndrome 37.44 13.74 46 889091 9521 63600074
Ligament operation 37.37 13.74 13 889124 7 63609588
Tinnitus 37.35 13.74 296 888841 33837 63575758
Neoplasm recurrence 37.32 13.74 4 889133 3735 63605860
Microcytic anaemia 37.29 13.74 9 889128 4629 63604966
Pulmonary arterial pressure increased 37.26 13.74 6 889131 4110 63605485
Lung transplant 37.16 13.74 6 889131 4102 63605493
Ovarian neoplasm 37.16 13.74 43 889094 540 63609055
Ocular icterus 37.07 13.74 12 889125 5086 63604509
Cardiac murmur 37.00 13.74 64 889073 11499 63598096
Frustration tolerance decreased 36.98 13.74 175 888962 5950 63603645
Tumour haemorrhage 36.83 13.74 3 889134 3490 63606105
Rebound effect 36.78 13.74 11 889126 4906 63604689
Body height below normal 36.76 13.74 79 889058 1739 63607856
Visual impairment 36.76 13.74 1307 887830 72770 63536825
Disturbance in social behaviour 36.73 13.74 5 889132 3882 63605713
Dermatitis atopic 36.59 13.74 5 889132 3871 63605724
Mean cell volume increased 36.48 13.74 12 889125 5034 63604561
Pain of skin 36.41 13.74 241 888896 9306 63600289
Encephalitis 36.33 13.74 74 889063 12497 63597098
Rheumatoid lung 36.31 13.74 95 889042 2384 63607211
Hyperventilation 36.11 13.74 25 889112 6815 63602780
Meniscus operation 36.08 13.74 23 889114 116 63609479
Flank pain 36.07 13.74 109 889028 16080 63593515
Mass excision 35.85 13.74 31 889106 266 63609329
Loose body in joint 35.78 13.74 62 889075 1156 63608439
Injection site hyperaesthesia 35.77 13.74 17 889120 41 63609554
Urine leukocyte esterase positive 35.66 13.74 3 889134 3400 63606195
Extrasystoles 35.59 13.74 24 889113 6634 63602961
Fungaemia 35.45 13.74 5 889132 3780 63605815
Hyperaesthesia teeth 35.40 13.74 71 889066 1486 63608109
Visual field defect 35.35 13.74 36 889101 8110 63601485
Aortic stenosis 35.31 13.74 22 889115 6343 63603252
High density lipoprotein decreased 35.17 13.74 6 889131 3940 63605655
Blood thyroid stimulating hormone decreased 35.15 13.74 14 889123 5216 63604379
Thrombophlebitis 35.06 13.74 17 889120 5637 63603958
JC virus infection 35.05 13.74 3 889134 3352 63606243
Eyelid ptosis 35.01 13.74 48 889089 9477 63600118
Low density lipoprotein increased 34.98 13.74 33 889104 7707 63601888
Urinary bladder suspension 34.84 13.74 21 889116 94 63609501
Epstein-Barr virus infection 34.84 13.74 75 889062 12413 63597182
Hospitalisation 34.84 13.74 780 888357 74427 63535168
Reaction to preservatives 34.76 13.74 23 889114 125 63609470
Viral infection 34.59 13.74 695 888442 35445 63574150
Upper limb fracture 34.58 13.74 335 888802 14531 63595064
Blood calcium increased 34.57 13.74 40 889097 8502 63601093
Vaginal haemorrhage 34.56 13.74 143 888994 19201 63590394
Communication disorder 34.47 13.74 5 889132 3701 63605894
Cell death 34.35 13.74 7 889130 4047 63605548
Multiple allergies 34.29 13.74 165 888972 5649 63603946
Dilatation ventricular 34.24 13.74 6 889131 3864 63605731
Ulcer 34.15 13.74 475 888662 22515 63587080
Thrombocytosis 34.15 13.74 29 889108 7127 63602468
Neck mass 34.14 13.74 128 889009 3916 63605679
Pyelonephritis acute 34.09 13.74 14 889123 5120 63604475
Trigger finger 34.02 13.74 117 889020 3428 63606167
Bursitis 34.00 13.74 449 888688 21036 63588559
Lack of injection site rotation 33.92 13.74 32 889105 311 63609284
Pulmonary sarcoidosis 33.79 13.74 58 889079 1073 63608522
Generalised oedema 33.73 13.74 160 888977 20693 63588902
Sexual dysfunction 33.70 13.74 24 889113 6447 63603148
Hypercalcaemia 33.66 13.74 274 888863 31142 63578453
Dilatation atrial 33.66 13.74 4 889133 3446 63606149
Troponin I increased 33.64 13.74 6 889131 3815 63605780
Oral candidiasis 33.63 13.74 185 888952 23027 63586568
Mouth haemorrhage 33.62 13.74 52 889085 9767 63599828
Spinal column injury 33.54 13.74 77 889060 1775 63607820
Abnormal dreams 33.43 13.74 57 889080 10299 63599296
Contrast media allergy 33.38 13.74 84 889053 2057 63607538
Spinal compression fracture 33.26 13.74 99 889038 14676 63594919
Hepatosplenomegaly 33.23 13.74 16 889121 5327 63604268
Post transplant lymphoproliferative disorder 33.20 13.74 50 889087 9494 63600101
Urine analysis abnormal 33.19 13.74 19 889118 5737 63603858
Skin papilloma 33.14 13.74 151 888986 5052 63604543
Lung opacity 33.04 13.74 3 889134 3196 63606399
Injection site plaque 32.95 13.74 18 889119 64 63609531
Sunburn 32.88 13.74 111 889026 3221 63606374
Polyarthritis 32.78 13.74 238 888899 9477 63600118
Haemoperitoneum 32.67 13.74 7 889130 3908 63605687
Social avoidant behaviour 32.66 13.74 11 889126 4546 63605049
Dysaesthesia 32.56 13.74 14 889123 4981 63604614
Peripheral arterial occlusive disease 32.51 13.74 29 889108 6958 63602637
Gout 32.50 13.74 168 888969 21245 63588350
Epicondylitis 32.47 13.74 76 889061 1775 63607820
Lymph node pain 32.37 13.74 63 889074 1289 63608306
Diffuse large B-cell lymphoma recurrent 32.36 13.74 3 889134 3143 63606452
Diverticulum 32.26 13.74 85 889052 13113 63596482
Enterobacter infection 32.12 13.74 6 889131 3690 63605905
Injection site infection 32.09 13.74 76 889061 1789 63607806
Nephrogenic anaemia 32.08 13.74 4 889133 3321 63606274
Paraparesis 31.94 13.74 5 889132 3497 63606098
Craniocerebral injury 31.87 13.74 9 889128 4167 63605428
Escherichia sepsis 31.85 13.74 31 889106 7134 63602461
Rocky mountain spotted fever 31.82 13.74 13 889124 18 63609577
Blood immunoglobulin E increased 31.82 13.74 7 889130 3837 63605758
Exposed bone in jaw 31.75 13.74 5 889132 3482 63606113
Ingrown hair 31.74 13.74 40 889097 552 63609043
Jugular vein thrombosis 31.67 13.74 7 889130 3824 63605771
Focal dyscognitive seizures 31.64 13.74 4 889133 3286 63606309
Anger 31.59 13.74 111 889026 15630 63593965
Premature labour 31.58 13.74 35 889102 7585 63602010
Vitreous haemorrhage 31.57 13.74 3 889134 3082 63606513
Megacolon 31.54 13.74 3 889134 3079 63606516
Stenotrophomonas infection 31.51 13.74 3 889134 3077 63606518
Pharyngitis 31.44 13.74 401 888736 18638 63590957
Oesophageal varices haemorrhage 31.30 13.74 6 889131 3623 63605972
Seronegative arthritis 31.26 13.74 96 889041 2647 63606948
Laryngospasm 31.24 13.74 5 889132 3440 63606155
Venous injury 31.21 13.74 40 889097 562 63609033
Autoimmune hepatitis 31.20 13.74 57 889080 10027 63599568
Seasonal allergy 31.20 13.74 272 888865 11454 63598141
Gangrene 31.19 13.74 33 889104 7305 63602290
Obstruction 31.11 13.74 4 889133 3244 63606351
Intracardiac thrombus 31.07 13.74 7 889130 3774 63605821
Acute graft versus host disease in intestine 31.06 13.74 6 889131 3603 63605992
Arthroscopic surgery 31.04 13.74 13 889124 20 63609575
Eczema 31.03 13.74 261 888876 29459 63580136
Injection related reaction 31.00 13.74 42 889095 625 63608970
Ear disorder 30.94 13.74 105 889032 3055 63606540
Malabsorption 30.91 13.74 11 889126 4392 63605203
Liver transplant 30.89 13.74 9 889128 4083 63605512
Diarrhoea haemorrhagic 30.85 13.74 68 889069 11159 63598436
Urinary tract infection 30.84 13.74 2760 886377 228836 63380759
Clostridial infection 30.83 13.74 16 889121 5103 63604492
Sputum culture positive 30.82 13.74 3 889134 3023 63606572
Acute psychosis 30.72 13.74 7 889130 3745 63605850
Mammoplasty 30.72 13.74 26 889111 216 63609379
Needle issue 30.63 13.74 226 888911 9046 63600549
Hearing aid user 30.53 13.74 15 889122 40 63609555
Conjunctival hyperaemia 30.51 13.74 8 889129 3891 63605704
Ear discomfort 30.37 13.74 188 888949 7092 63602503
Wound dehiscence 30.31 13.74 22 889115 5852 63603743
Arthritis infective 30.25 13.74 183 888954 6847 63602748
Gastric disorder 30.15 13.74 568 888569 28629 63580966
Throat tightness 30.15 13.74 191 888946 22969 63586626
Abdominal tenderness 30.15 13.74 52 889085 9353 63600242
Injection site scab 29.95 13.74 29 889108 292 63609303
Artificial crown procedure 29.90 13.74 26 889111 225 63609370
Epidural injection 29.68 13.74 9 889128 0 63609595
False positive tuberculosis test 29.63 13.74 12 889125 16 63609579
Herpes simplex 29.62 13.74 63 889074 10473 63599122
Muscle swelling 29.51 13.74 43 889094 687 63608908
Adrenal insufficiency 29.51 13.74 185 888952 22302 63587293
Eye inflammation 29.49 13.74 139 888998 4718 63604877
White blood cells urine positive 29.48 13.74 19 889118 5379 63604216
Multiple injuries 29.44 13.74 5 889132 3294 63606301
Urinary tract infection bacterial 29.39 13.74 17 889120 5104 63604491
Gastrointestinal sounds abnormal 29.37 13.74 15 889122 4828 63604767
Anal fistula 29.36 13.74 18 889119 5235 63604360
Cast application 29.30 13.74 11 889126 10 63609585
Bicytopenia 29.18 13.74 7 889130 3615 63605980
Neurogenic bladder 29.14 13.74 7 889130 3612 63605983
Endocarditis 29.02 13.74 53 889084 9325 63600270
Type IV hypersensitivity reaction 28.80 13.74 6 889131 3416 63606179
Blood iron abnormal 28.77 13.74 55 889082 1110 63608485
Injection site erosion 28.75 13.74 19 889118 103 63609492
Diffuse alveolar damage 28.66 13.74 5 889132 3230 63606365
Thyroid cancer 28.60 13.74 120 889017 3871 63605724
Prothrombin time shortened 28.56 13.74 3 889134 2846 63606749
Device breakage 28.44 13.74 48 889089 8707 63600888
Hepatocellular carcinoma 28.29 13.74 45 889092 8358 63601237
Product administered to patient of inappropriate age 28.28 13.74 14 889123 4587 63605008
Anaphylactoid reaction 28.25 13.74 15 889122 4723 63604872
Periodontitis 28.17 13.74 11 889126 4148 63605447
Intentional dose omission 28.17 13.74 153 888984 5499 63604096
Macular oedema 28.16 13.74 16 889121 4851 63604744
Facial paralysis 28.12 13.74 150 888987 18816 63590779
Skin reaction 28.07 13.74 277 888860 12075 63597520
Psychiatric symptom 28.05 13.74 27 889110 6246 63603349
Spondylitis 28.01 13.74 100 889037 2986 63606609
Extravasation 27.98 13.74 5 889132 3175 63606420
Coronary artery occlusion 27.85 13.74 98 889039 13793 63595802
Body height decreased 27.83 13.74 38 889099 7516 63602079
Anal haemorrhage 27.82 13.74 6 889131 3334 63606261
Pulmonary function test abnormal 27.79 13.74 5 889132 3159 63606436
Hepatitis toxic 27.63 13.74 13 889124 4387 63605208
Miliaria 27.61 13.74 56 889081 1182 63608413
Application site pain 27.54 13.74 12 889125 4236 63605359
Weight bearing difficulty 27.52 13.74 91 889046 2612 63606983
Fracture 27.43 13.74 149 888988 18606 63590989
Sputum increased 27.43 13.74 8 889129 3627 63605968
Local reaction 27.43 13.74 34 889103 461 63609134
Upper respiratory tract inflammation 27.33 13.74 9 889128 3773 63605822
Pollakiuria 27.31 13.74 290 888847 31240 63578355
Rhonchi 27.30 13.74 7 889130 3456 63606139
Restless legs syndrome 27.29 13.74 132 889005 16984 63592611
Adjustment disorder 27.24 13.74 3 889134 2742 63606853
Panic attack 27.17 13.74 173 888964 20780 63588815
Product physical issue 27.14 13.74 7 889130 3442 63606153
Hepatic enzyme abnormal 27.06 13.74 155 888982 5684 63603911
Kidney fibrosis 27.02 13.74 5 889132 3096 63606499
Deafness transitory 26.98 13.74 44 889093 779 63608816
Rib fracture 26.98 13.74 207 888930 23831 63585764
Secondary immunodeficiency 26.97 13.74 3 889134 2721 63606874
Large intestinal ulcer 26.94 13.74 12 889125 4181 63605414
Neurological symptom 26.86 13.74 33 889104 6831 63602764
Tonsillectomy 26.83 13.74 34 889103 472 63609123
Pneumonia klebsiella 26.82 13.74 11 889126 4026 63605569
Investigation abnormal 26.72 13.74 58 889079 1286 63608309
Eating disorder 26.56 13.74 130 889007 16675 63592920
Gastric bypass 26.46 13.74 50 889087 1000 63608595
Monocyte count decreased 26.24 13.74 4 889133 2853 63606742
Enteritis infectious 26.13 13.74 5 889132 3023 63606572
Plantar fasciitis 26.13 13.74 92 889045 2728 63606867
Self-injurious ideation 26.11 13.74 6 889131 3191 63606404
Procedural haemorrhage 26.04 13.74 13 889124 4239 63605356
Urinary hesitation 25.99 13.74 8 889129 3502 63606093
Wisdom teeth removal 25.93 13.74 29 889108 350 63609245
Meningitis cryptococcal 25.90 13.74 5 889132 3004 63606591
Internal haemorrhage 25.87 13.74 41 889096 7626 63601969
Movement disorder 25.86 13.74 187 888950 21813 63587782
Escherichia test positive 25.84 13.74 4 889133 2821 63606774
Acute abdomen 25.83 13.74 4 889133 2820 63606775
Butterfly rash 25.81 13.74 53 889084 1129 63608466
Tendonitis 25.80 13.74 408 888729 19874 63589721
Infected cyst 25.77 13.74 48 889089 949 63608646
Lymphadenopathy 25.76 13.74 834 888303 45852 63563743
Middle ear effusion 25.68 13.74 73 889064 1926 63607669
Liver disorder 25.66 13.74 550 888587 52801 63556794
Precancerous cells present 25.64 13.74 48 889089 953 63608642
Stillbirth 25.64 13.74 9 889128 3624 63605971
Cold sweat 25.60 13.74 128 889009 16327 63593268
Calciphylaxis 25.53 13.74 7 889130 3305 63606290
Bone lesion 25.53 13.74 20 889117 5117 63604478
Dry skin 25.46 13.74 903 888234 50258 63559337
Peripheral motor neuropathy 25.43 13.74 5 889132 2965 63606630
Metabolic surgery 25.42 13.74 45 889092 854 63608741
Conduction disorder 25.41 13.74 5 889132 2963 63606632
Malignant pleural effusion 25.39 13.74 5 889132 2962 63606633
Ligament disorder 25.36 13.74 27 889110 307 63609288
Blood parathyroid hormone increased 25.36 13.74 6 889131 3128 63606467
Fibrosis 25.33 13.74 17 889120 4711 63604884
Nail discolouration 25.30 13.74 84 889053 2416 63607179
Faeces soft 25.26 13.74 26 889111 5829 63603766
Vascular pseudoaneurysm 25.24 13.74 6 889131 3118 63606477
Abdominal operation 25.21 13.74 32 889105 445 63609150
Linear IgA disease 25.21 13.74 4 889133 2770 63606825
Tonsillar ulcer 25.20 13.74 30 889107 389 63609206
Amnesia 25.18 13.74 491 888646 47778 63561817
Focal segmental glomerulosclerosis 25.12 13.74 5 889132 2939 63606656
Injection site cellulitis 25.11 13.74 61 889076 1460 63608135
Urinary tract obstruction 25.03 13.74 12 889125 4005 63605590
Abdominal abscess 25.00 13.74 30 889107 6274 63603321
Product use issue 24.98 13.74 1777 887360 149938 63459657
Prosthesis user 24.91 13.74 15 889122 67 63609528
Myoglobin blood increased 24.88 13.74 4 889133 2743 63606852
Tendon disorder 24.85 13.74 161 888976 6171 63603424
Vascular purpura 24.85 13.74 3 889134 2553 63607042
Intestinal sepsis 24.78 13.74 37 889100 605 63608990
Pneumonia staphylococcal 24.76 13.74 15 889122 4391 63605204
Hypokinesia 24.75 13.74 131 889006 16465 63593130
Tonsillitis 24.72 13.74 151 888986 5669 63603926
Cartilage injury 24.61 13.74 56 889081 1283 63608312
Ototoxicity 24.58 13.74 4 889133 2719 63606876
Streptococcal bacteraemia 24.57 13.74 6 889131 3061 63606534
Disability assessment scale score increased 24.52 13.74 3 889134 2527 63607068
Pneumonia pseudomonal 24.48 13.74 19 889118 4884 63604711
Lacrimation increased 24.46 13.74 372 888765 17974 63591621
PO2 decreased 24.46 13.74 4 889133 2709 63606886
Dizziness postural 24.45 13.74 62 889075 9690 63599905
Hypertensive heart disease 24.26 13.74 11 889126 3793 63605802
Wrong technique in device usage process 24.15 13.74 91 889046 2791 63606804
Blood immunoglobulin G decreased 24.09 13.74 4 889133 2679 63606916
Cytomegalovirus colitis 24.07 13.74 12 889125 3916 63605679
Haemorrhoidal haemorrhage 24.00 13.74 26 889111 5693 63603902
Arthroscopy 23.97 13.74 32 889105 469 63609126
Rheumatic fever 23.91 13.74 214 888923 9080 63600515
Ankle arthroplasty 23.90 13.74 44 889093 862 63608733
Eyelid exfoliation 23.88 13.74 17 889120 106 63609489
Diabetic retinopathy 23.85 13.74 5 889132 2834 63606761
Brain abscess 23.83 13.74 14 889123 4167 63605428
Basal cell carcinoma 23.79 13.74 575 888562 30263 63579332
Angle closure glaucoma 23.77 13.74 4 889133 2653 63606942
Bursa disorder 23.68 13.74 21 889116 187 63609408
Psychiatric decompensation 23.68 13.74 3 889134 2460 63607135
Dysphonia 23.67 13.74 821 888316 45561 63564034
Pharyngeal swelling 23.63 13.74 25 889112 5534 63604061
Hyperthermia malignant 23.62 13.74 3 889134 2456 63607139
Metastases to meninges 23.56 13.74 5 889132 2810 63606785
Arterial occlusive disease 23.36 13.74 38 889099 6995 63602600
Blood creatine phosphokinase MB increased 23.33 13.74 4 889133 2617 63606978
Concomitant disease progression 23.24 13.74 8 889129 3261 63606334
Hepatitis B virus test positive 23.22 13.74 30 889107 425 63609170
Alcoholism 23.21 13.74 9 889128 3408 63606187
Cardiac dysfunction 23.14 13.74 7 889130 3099 63606496
Livedo reticularis 23.10 13.74 11 889126 3686 63605909
Mycobacterium tuberculosis complex test 23.09 13.74 7 889130 0 63609595
Prescription drug used without a prescription 23.07 13.74 4 889133 2596 63606999
Eyelid oedema 23.06 13.74 89 889048 12190 63597405
Metastases to peritoneum 23.03 13.74 10 889127 3537 63606058
Optic ischaemic neuropathy 22.89 13.74 4 889133 2581 63607014
Mallory-Weiss syndrome 22.86 13.74 4 889133 2579 63607016
Paresis 22.86 13.74 10 889127 3522 63606073
Pulmonary sepsis 22.78 13.74 7 889130 3068 63606527
Polydipsia 22.77 13.74 28 889109 5793 63603802
Alcohol use 22.77 13.74 18 889119 4584 63605011
Gastric perforation 22.76 13.74 10 889127 3513 63606082
Spinal cord compression 22.76 13.74 27 889110 5676 63603919
Mole excision 22.70 13.74 16 889121 98 63609497
Accident at work 22.69 13.74 45 889092 934 63608661
Mucosal disorder 22.63 13.74 7 889130 3055 63606540
Limb mass 22.57 13.74 92 889045 2929 63606666
Haemoglobin increased 22.55 13.74 23 889114 5178 63604417
Bone deformity 22.54 13.74 23 889114 248 63609347
Biliary dyskinesia 22.53 13.74 3 889134 2369 63607226
Synovial disorder 22.48 13.74 44 889093 904 63608691
Scar excision 22.48 13.74 11 889126 29 63609566
Anion gap increased 22.43 13.74 7 889130 3037 63606558
Hypopnoea 22.39 13.74 8 889129 3186 63606409
Paradoxical drug reaction 22.33 13.74 31 889106 6089 63603506
Lichenoid keratosis 22.29 13.74 9 889128 3325 63606270
Blindness 22.26 13.74 195 888942 21824 63587771
Ependymoma malignant 22.22 13.74 9 889128 12 63609583
Cataract 22.21 13.74 891 888246 50371 63559224
Manufacturing product shipping issue 22.18 13.74 15 889122 85 63609510
Bladder operation 22.15 13.74 39 889098 737 63608858
Therapy partial responder 22.12 13.74 70 889067 10178 63599417
Pneumonia influenzal 22.12 13.74 4 889133 2518 63607077
Hyperparathyroidism secondary 22.01 13.74 3 889134 2327 63607268
Proctitis 21.99 13.74 8 889129 3151 63606444
Joint injection 21.99 13.74 8 889129 6 63609589
Hyporeflexia 21.95 13.74 9 889128 3295 63606300
Biliary colic 21.90 13.74 10 889127 3434 63606161
Varices oesophageal 21.89 13.74 23 889114 5107 63604488
Type I hypersensitivity 21.78 13.74 11 889126 3563 63606032
Hepatic lesion 21.76 13.74 29 889108 5795 63603800
Procalcitonin increased 21.74 13.74 4 889133 2487 63607108
Drug effective for unapproved indication 21.73 13.74 12 889125 3696 63605899
Venous thrombosis limb 21.65 13.74 13 889124 3824 63605771
Electric shock 21.63 13.74 48 889089 1081 63608514
X-ray abnormal 21.60 13.74 57 889080 1438 63608157
Urine abnormality 21.56 13.74 43 889094 7319 63602276
Sensory disturbance 21.56 13.74 101 889036 13107 63596488
Thinking abnormal 21.55 13.74 84 889053 11472 63598123
Epstein-Barr virus associated lymphoproliferative disorder 21.54 13.74 8 889129 3111 63606484
Disease recurrence 21.54 13.74 305 888832 31205 63578390
Enterocolitis infectious 21.41 13.74 4 889133 2460 63607135
Hypertensive emergency 21.33 13.74 3 889134 2273 63607322
Skin irritation 21.29 13.74 207 888930 8987 63600608
Nail operation 21.22 13.74 22 889115 242 63609353
Squamous cell carcinoma of skin 21.09 13.74 88 889049 11788 63597807
Large intestinal stenosis 21.08 13.74 4 889133 2433 63607162
Ankle fracture 21.07 13.74 302 888835 14408 63595187
Liver abscess 21.07 13.74 25 889112 5255 63604340
CD4 lymphocytes decreased 21.06 13.74 4 889133 2431 63607164
Autoimmune haemolytic anaemia 21.01 13.74 41 889096 7035 63602560
Folate deficiency 21 13.74 6 889131 2757 63606838
Acinetobacter infection 20.99 13.74 4 889133 2425 63607170
Ovarian cancer 20.90 13.74 96 889041 3223 63606372
Musculoskeletal injury 20.86 13.74 18 889119 154 63609441
Human herpesvirus 6 infection 20.85 13.74 20 889117 4634 63604961
Thyroiditis 20.84 13.74 12 889125 3612 63605983
Staphylococcal infection 20.84 13.74 876 888261 49802 63559793
Pneumomediastinum 20.78 13.74 7 889130 2893 63606702
Non-small cell lung cancer 20.78 13.74 22 889115 4868 63604727
Peptic ulcer 20.76 13.74 26 889111 5337 63604258
Spinal nerve stimulator implantation 20.75 13.74 14 889123 79 63609516
Exposure to toxic agent 20.72 13.74 33 889104 6126 63603469
Bursa removal 20.71 13.74 9 889128 16 63609579
Angiopathy 20.67 13.74 34 889103 6231 63603364
Extremity necrosis 20.66 13.74 6 889131 2728 63606867
Alanine aminotransferase abnormal 20.58 13.74 164 888973 6724 63602871
Product dose omission in error 20.51 13.74 5 889132 2554 63607041
Gastric infection 20.49 13.74 94 889043 3154 63606441
Hostility 20.48 13.74 3 889134 2204 63607391
Tumour marker increased 20.46 13.74 11 889126 3439 63606156
Right ventricular dysfunction 20.43 13.74 3 889134 2200 63607395
Road traffic accident 20.42 13.74 562 888575 30183 63579412
Dactylitis 20.41 13.74 66 889071 1872 63607723
Pre-eclampsia 20.39 13.74 34 889103 6197 63603398
Hyperaemia 20.37 13.74 6 889131 2703 63606892
Dissociation 20.34 13.74 8 889129 3003 63606592
Quadriparesis 20.29 13.74 7 889130 2850 63606745
Swelling of eyelid 20.29 13.74 3 889134 2189 63607406
Oesophageal candidiasis 20.08 13.74 51 889086 7966 63601629
Infiltration anaesthesia 20.02 13.74 17 889120 142 63609453
Oligohydramnios 19.98 13.74 9 889128 3115 63606480
Incorrect dose administered 19.97 13.74 1027 888110 59738 63549857
Device related sepsis 19.95 13.74 25 889112 5130 63604465
Gastrointestinal oedema 19.91 13.74 4 889133 2336 63607259
Fixed eruption 19.88 13.74 3 889134 2156 63607439
Skin atrophy 19.87 13.74 126 889011 4794 63604801
Scarlet fever 19.83 13.74 14 889123 86 63609509
Trismus 19.78 13.74 23 889114 4878 63604717
Malignant neoplasm of conjunctiva 19.76 13.74 11 889126 41 63609554
Aphonia 19.75 13.74 195 888942 8502 63601093
Hypoproteinaemia 19.74 13.74 11 889126 3371 63606224
Cerebrovascular disorder 19.71 13.74 12 889125 3503 63606092
Hepatitis B reactivation 19.67 13.74 23 889114 4866 63604729
Psychotic symptom 19.62 13.74 3 889134 2135 63607460
Dermatitis exfoliative generalised 19.62 13.74 32 889105 5884 63603711
Initial insomnia 19.62 13.74 31 889106 5773 63603822
Oesophageal operation 19.62 13.74 8 889129 11 63609584
Pulmonary infarction 19.51 13.74 10 889127 3212 63606383
Pulmonary mass 19.50 13.74 451 888686 23565 63586030
Dysphoria 19.49 13.74 19 889118 4369 63605226
Galactorrhoea 19.48 13.74 10 889127 3209 63606386
Bile duct stone 19.41 13.74 24 889113 4954 63604641
Post procedural haematoma 19.40 13.74 4 889133 2294 63607301
Choking 19.39 13.74 77 889060 10461 63599134
Tic 19.34 13.74 6 889131 2613 63606982
Acute lymphocytic leukaemia 19.33 13.74 19 889118 4352 63605243
Essential hypertension 19.26 13.74 26 889111 5168 63604427
Bone density abnormal 19.26 13.74 82 889055 2663 63606932
Breast cancer metastatic 19.23 13.74 44 889093 7125 63602470
Whipple's disease 19.22 13.74 8 889129 12 63609583
Nail psoriasis 19.21 13.74 25 889112 357 63609238
Exposure via skin contact 19.20 13.74 17 889120 151 63609444
Procedural complication 19.15 13.74 45 889092 7220 63602375
Gastrointestinal motility disorder 19.13 13.74 26 889111 5153 63604442
Abdominoplasty 19.07 13.74 10 889127 32 63609563
Aortic dissection 19.06 13.74 12 889125 3440 63606155
Ingrowing nail 19.04 13.74 70 889067 2121 63607474
Precancerous skin lesion 19.04 13.74 46 889091 1097 63608498
Idiopathic intracranial hypertension 19.04 13.74 6 889131 2587 63607008
Tendon injury 19.02 13.74 60 889077 1679 63607916
Central venous catheterisation 18.98 13.74 7 889130 2734 63606861
Temperature regulation disorder 18.97 13.74 18 889119 4193 63605402
Prostatic operation 18.97 13.74 19 889118 200 63609395
Suicidal behaviour 18.96 13.74 8 889129 2879 63606716
Subacute cutaneous lupus erythematosus 18.90 13.74 9 889128 3016 63606579
Tinea pedis 18.89 13.74 67 889070 1994 63607601
Muscle twitching 18.87 13.74 169 888968 18829 63590766
Skin sensitisation 18.82 13.74 37 889100 763 63608832
Ischaemic cerebral infarction 18.80 13.74 3 889134 2069 63607526
Mean cell haemoglobin concentration decreased 18.75 13.74 14 889123 3670 63605925
Loss of libido 18.68 13.74 5 889132 2399 63607196
Hepatic cyst 18.67 13.74 27 889110 5213 63604382
Bladder repair 18.64 13.74 11 889126 47 63609548
Urinary sediment present 18.63 13.74 4 889133 2230 63607365
Product container seal issue 18.60 13.74 12 889125 62 63609533
Gastrointestinal stoma complication 18.54 13.74 4 889133 2222 63607373
Bipolar disorder 18.54 13.74 41 889096 6720 63602875
Uterine dilation and curettage 18.53 13.74 28 889109 463 63609132
Metastases to lymph nodes 18.50 13.74 60 889077 8657 63600938
Amenorrhoea 18.47 13.74 39 889098 6500 63603095
Bite 18.46 13.74 26 889111 402 63609193
Single functional kidney 18.41 13.74 14 889123 98 63609497
Hyperleukocytosis 18.41 13.74 3 889134 2037 63607558
Mechanical ventilation 18.38 13.74 5 889132 2373 63607222
Bronchial obstruction 18.33 13.74 5 889132 2369 63607226
Intervertebral disc compression 18.27 13.74 42 889095 969 63608626
Hypochromic anaemia 18.26 13.74 5 889132 2363 63607232
Varicella zoster virus infection 18.26 13.74 16 889121 3872 63605723
Organ failure 18.24 13.74 14 889123 3619 63605976
Disease susceptibility 18.22 13.74 20 889117 236 63609359
Tendon sheath incision 18.22 13.74 10 889127 36 63609559
Nasal polyps 18.20 13.74 14 889123 3615 63605980
Hepatic cirrhosis 18.17 13.74 254 888883 26044 63583551
Bruxism 18.15 13.74 14 889123 3610 63605985
Blood glucose fluctuation 18.12 13.74 34 889103 5921 63603674
Amyotrophic lateral sclerosis 18.11 13.74 57 889080 1593 63608002
Hypoaesthesia oral 18.06 13.74 90 889047 11490 63598105
Viraemia 18.04 13.74 5 889132 2344 63607251
Laryngeal disorder 18.02 13.74 39 889098 863 63608732
Needle track marks 18.01 13.74 10 889127 37 63609558
Pancreatitis necrotising 18.01 13.74 11 889126 3206 63606389
Cytology abnormal 18.01 13.74 23 889114 322 63609273
Eosinophil count decreased 17.99 13.74 7 889130 2645 63606950
Red blood cell sedimentation rate decreased 17.99 13.74 19 889118 214 63609381
Haematocrit increased 17.96 13.74 12 889125 3333 63606262
Apraxia 17.92 13.74 6 889131 2489 63607106
Urinary bladder haemorrhage 17.91 13.74 5 889132 2333 63607262
Enuresis 17.90 13.74 8 889129 2782 63606813
Myelopathy 17.89 13.74 17 889120 3957 63605638
Oral infection 17.86 13.74 120 889017 4657 63604938
Mean cell haemoglobin increased 17.86 13.74 11 889126 3191 63606404
Mesenteritis 17.79 13.74 18 889119 192 63609403
Klebsiella sepsis 17.77 13.74 7 889130 2625 63606970
Laboratory test abnormal 17.76 13.74 446 888691 23617 63585978
Serum sickness 17.72 13.74 11 889126 3178 63606417
Allergic sinusitis 17.67 13.74 27 889110 451 63609144
Hypercoagulation 17.67 13.74 7 889130 2616 63606979
Skin cancer 17.62 13.74 247 888890 11727 63597868
Peripheral vascular disorder 17.57 13.74 47 889090 7214 63602381
Carbon dioxide decreased 17.53 13.74 10 889127 3025 63606570
Cryptococcosis 17.52 13.74 8 889129 2747 63606848
Retinal toxicity 17.50 13.74 49 889088 1281 63608314
In vitro fertilisation 17.48 13.74 11 889126 54 63609541
Limb crushing injury 17.43 13.74 18 889119 197 63609398
Pharyngeal operation 17.40 13.74 6 889131 3 63609592
Body tinea 17.38 13.74 48 889089 1245 63608350
Nervous system disorder 17.37 13.74 219 888918 22859 63586736
Hepatitis B 17.36 13.74 52 889085 7693 63601902
Application site rash 17.35 13.74 3 889134 1951 63607644
Coronavirus infection 17.34 13.74 31 889106 5499 63604096
Toxoplasmosis 17.34 13.74 6 889131 2438 63607157
Continuous haemodiafiltration 17.30 13.74 3 889134 1947 63607648
Breast mass 17.30 13.74 129 889008 5181 63604414
Optic neuropathy 17.28 13.74 10 889127 3001 63606594
Swollen joint count increased 17.26 13.74 172 888965 7517 63602078
Mononucleosis syndrome 17.25 13.74 14 889123 109 63609486
Peripheral sensorimotor neuropathy 17.24 13.74 7 889130 2578 63607017
Cholecystectomy 17.23 13.74 178 888959 7854 63601741
Coronary artery thrombosis 17.23 13.74 9 889128 2860 63606735
Premature baby 17.22 13.74 12 889125 3260 63606335
Neuroma 17.20 13.74 19 889118 226 63609369
Meningitis aseptic 17.19 13.74 33 889104 5697 63603898
Immunosuppression 17.18 13.74 225 888912 10521 63599074
Paraplegia 17.14 13.74 22 889115 4468 63605127
Oesophageal pain 17.13 13.74 12 889125 3251 63606344
Intra-abdominal fluid collection 17.11 13.74 8 889129 2709 63606886
Injection site streaking 17.07 13.74 10 889127 42 63609553
Actinic keratosis 17.07 13.74 28 889109 5137 63604458
Superinfection 17.06 13.74 17 889120 3869 63605726
Colitis microscopic 17.05 13.74 167 888970 7265 63602330
Hyperparathyroidism 17.05 13.74 9 889128 2843 63606752
Diabetic neuropathy 17.03 13.74 32 889105 5569 63604026
Hereditary angioedema 16.96 13.74 17 889120 3859 63605736
Nasal discomfort 16.96 13.74 110 889027 4218 63605377
Dyschezia 16.95 13.74 6 889131 2404 63607191
Increased appetite 16.91 13.74 77 889060 10069 63599526
Nail bed disorder 16.89 13.74 18 889119 205 63609390
Vitamin B12 deficiency 16.87 13.74 31 889106 5441 63604154
Biliary obstruction 16.85 13.74 17 889120 3847 63605748
Large intestinal haemorrhage 16.82 13.74 7 889130 2540 63607055
Hypersensitivity pneumonitis 16.81 13.74 12 889125 3220 63606375
Staphylococcal skin infection 16.78 13.74 47 889090 1229 63608366
Blood creatinine decreased 16.78 13.74 46 889091 7004 63602591
Vaginal operation 16.78 13.74 6 889131 4 63609591
Libido decreased 16.70 13.74 25 889112 4759 63604836
Intervertebral disc disorder 16.69 13.74 112 889025 4345 63605250
Peritoneal dialysis complication 16.64 13.74 5 889132 2223 63607372
Laser therapy 16.64 13.74 8 889129 20 63609575
Transaminases abnormal 16.63 13.74 34 889103 722 63608873
Device alarm issue 16.57 13.74 3 889134 1887 63607708
Pancreatitis chronic 16.55 13.74 15 889122 3571 63606024
Gastrointestinal toxicity 16.54 13.74 30 889107 5292 63604303
Intervertebral disc injury 16.54 13.74 15 889122 138 63609457
Rheumatoid nodule removal 16.49 13.74 5 889132 0 63609595
Blood test 16.49 13.74 5 889132 0 63609595
Neurectomy 16.49 13.74 5 889132 0 63609595
Differentiation syndrome 16.49 13.74 4 889133 2050 63607545
Rheumatoid factor 16.48 13.74 14 889123 117 63609478
Tonic convulsion 16.46 13.74 3 889134 1878 63607717
Micturition urgency 16.45 13.74 80 889057 10279 63599316
Periorbital swelling 16.40 13.74 3 889134 1873 63607722
Cerebellar infarction 16.40 13.74 13 889124 3306 63606289
Live birth 16.39 13.74 89 889048 11115 63598480
Discontinued product administered 16.39 13.74 10 889127 46 63609549
Lower respiratory tract inflammation 16.35 13.74 13 889124 98 63609497
Intervertebral discitis 16.34 13.74 100 889037 3757 63605838
Chorioretinopathy 16.28 13.74 5 889132 2192 63607403
Idiopathic pulmonary fibrosis 16.25 13.74 17 889120 3783 63605812
Immobile 16.25 13.74 140 888997 5875 63603720
Peripheral coldness 16.19 13.74 115 889022 13469 63596126
Hair disorder 16.19 13.74 38 889099 889 63608706
Reversible cerebral vasoconstriction syndrome 16.19 13.74 6 889131 2336 63607259
Red blood cell sedimentation rate 16.18 13.74 97 889040 3617 63605978
Flat affect 16.17 13.74 3 889134 1854 63607741
Streptococcal infection 16.17 13.74 166 888971 7313 63602282
Cardiovascular insufficiency 16.10 13.74 8 889129 2616 63606979
Neutrophil count abnormal 16.08 13.74 10 889127 2886 63606709
Neck deformity 15.99 13.74 56 889081 1656 63607939
Cold-stimulus headache 15.92 13.74 7 889130 13 63609582
Erosive oesophagitis 15.91 13.74 8 889129 2598 63606997
Limb reconstructive surgery 15.91 13.74 10 889127 49 63609546
Gingival injury 15.86 13.74 8 889129 23 63609572
Unintended pregnancy 15.83 13.74 12 889125 3122 63606473
Allergic oedema 15.82 13.74 33 889104 711 63608884
Sciatic nerve neuropathy 15.82 13.74 21 889116 306 63609289
Facial paresis 15.72 13.74 27 889110 4865 63604730
Spondyloarthropathy 15.72 13.74 34 889103 752 63608843
Coagulation time prolonged 15.70 13.74 5 889132 2141 63607454
Abnormal faeces 15.68 13.74 36 889101 5823 63603772
Vestibular disorder 15.64 13.74 6 889131 2287 63607308
Drug eruption 15.63 13.74 628 888509 35508 63574087
Anaesthetic complication 15.62 13.74 8 889129 2571 63607024
Osteoporosis postmenopausal 15.59 13.74 7 889130 14 63609581
Melkersson-Rosenthal syndrome 15.59 13.74 7 889130 14 63609581
Pneumoperitoneum 15.56 13.74 9 889128 2702 63606893
Stem cell transplant 15.54 13.74 15 889122 3466 63606129
Cutaneous T-cell lymphoma 15.54 13.74 69 889068 2283 63607312
Multiple fractures 15.50 13.74 139 888998 5901 63603694
Pulmonary toxicity 15.47 13.74 63 889074 8498 63601097
Adrenocortical insufficiency acute 15.47 13.74 8 889129 2557 63607038
Ureteric obstruction 15.45 13.74 7 889130 2415 63607180
Overwork 15.45 13.74 10 889127 52 63609543
Acute sinusitis 15.30 13.74 21 889116 4145 63605450
Bronchiectasis 15.30 13.74 123 889014 14017 63595578
Regurgitation 15.27 13.74 5 889132 2104 63607491
Inflammatory marker increased 15.25 13.74 181 888956 8270 63601325
Prolonged labour 15.20 13.74 24 889113 413 63609182
Haemoglobin abnormal 15.19 13.74 38 889099 5966 63603629
Fallopian tube cancer 15.17 13.74 8 889129 26 63609569
Pelvic venous thrombosis 15.15 13.74 3 889134 1770 63607825
Traumatic haematoma 15.14 13.74 4 889133 1936 63607659
Breast operation 15.14 13.74 18 889119 233 63609362
Joint ankylosis 15.08 13.74 33 889104 736 63608859
Insomnia 15.07 13.74 2446 886691 195390 63414205
Tumour pain 15.06 13.74 4 889133 1929 63607666
Gastric operation 15.03 13.74 18 889119 235 63609360
Septic embolus 15.02 13.74 3 889134 1759 63607836
Abnormal loss of weight 14.97 13.74 52 889085 7348 63602247
Pruritus allergic 14.97 13.74 36 889101 856 63608739
Labile blood pressure 14.94 13.74 5 889132 2075 63607520
Bronchial hyperreactivity 14.91 13.74 8 889129 2504 63607091
Chest X-ray abnormal 14.87 13.74 45 889092 6636 63602959
Oral pain 14.85 13.74 278 888859 27215 63582380
Uterine cancer 14.82 13.74 79 889058 2819 63606776
Gingival bleeding 14.81 13.74 132 889005 14722 63594873
Blood urea decreased 14.80 13.74 10 889127 2761 63606834
Abdominal pain upper 14.79 13.74 2151 886986 172879 63436716
Synovial rupture 14.74 13.74 20 889117 298 63609297
Spinal meningioma benign 14.73 13.74 12 889125 94 63609501
Crying 14.72 13.74 372 888765 19718 63589877
Troponin T increased 14.70 13.74 7 889130 2346 63607249
Intentional underdose 14.69 13.74 5 889132 2053 63607542
Fear of disease 14.63 13.74 36 889101 869 63608726
Foaming at mouth 14.62 13.74 3 889134 1726 63607869
Polychondritis 14.60 13.74 24 889113 428 63609167
Splenic infarction 14.58 13.74 14 889123 3243 63606352
Muscle atrophy 14.56 13.74 77 889060 9681 63599914
Guillain-Barre syndrome 14.56 13.74 55 889082 7580 63602015
Synovectomy 14.48 13.74 17 889120 217 63609378
Septic arthritis staphylococcal 14.47 13.74 31 889106 681 63608914
Metastatic bronchial carcinoma 14.42 13.74 17 889120 218 63609377
Oesophageal stenosis 14.42 13.74 19 889118 3815 63605780
Lung carcinoma cell type unspecified stage 0 14.33 13.74 9 889128 44 63609551
Body temperature increased 14.33 13.74 390 888747 36276 63573319
Anal fissure 14.31 13.74 29 889108 4907 63604688
Skin candida 14.31 13.74 3 889134 1700 63607895
Large intestine polyp 14.30 13.74 89 889048 10748 63598847
HLA marker study positive 14.30 13.74 13 889124 120 63609475
Dry throat 14.28 13.74 140 888997 6092 63603503
Small intestinal perforation 14.20 13.74 9 889128 2571 63607024
Thrombocytopenic purpura 14.19 13.74 6 889131 2156 63607439
Papilloma excision 14.18 13.74 5 889132 3 63609592
Oral mucosal roughening 14.16 13.74 7 889130 19 63609576
Cerebral venous thrombosis 14.16 13.74 8 889129 2433 63607162
Disease complication 14.13 13.74 23 889114 4232 63605363
Intermenstrual bleeding 14.12 13.74 31 889106 5094 63604501
Labour complication 14.09 13.74 10 889127 62 63609533
Product taste abnormal 14.07 13.74 5 889132 1998 63607597
Chorea 14.03 13.74 5 889132 1995 63607600
Monocyte percentage increased 14.03 13.74 5 889132 1995 63607600
Labelled drug-disease interaction medication error 14.01 13.74 19 889118 283 63609312
Blood creatinine abnormal 13.99 13.74 22 889115 4105 63605490
Dysstasia 13.94 13.74 419 888718 22796 63586799
Renal stone removal 13.93 13.74 14 889123 148 63609447
Infectious mononucleosis 13.93 13.74 54 889083 1679 63607916
Monoparesis 13.87 13.74 12 889125 2922 63606673
Hypertonic bladder 13.84 13.74 16 889121 3402 63606193
Nasal septal operation 13.82 13.74 11 889126 83 63609512
Dermatitis infected 13.82 13.74 16 889121 201 63609394
Enterocolitis haemorrhagic 13.81 13.74 5 889132 1975 63607620
Papilloedema 13.80 13.74 35 889102 5470 63604125
Sebaceous gland infection 13.79 13.74 12 889125 104 63609491
Sinus operation 13.77 13.74 53 889084 1642 63607953

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AB01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Tumor necrosis factor alpha (TNF-alpha) inhibitors
FDA MoA N0000175451 Tumor Necrosis Factor Receptor Blocking Activity
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
FDA EPC N0000175610 Tumor Necrosis Factor Blocker

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Psoriasis with arthropathy indication 33339001
Rheumatoid arthritis indication 69896004 DOID:7148
Plaque psoriasis indication 200965009
Juvenile idiopathic arthritis indication 410502007
Sepsis contraindication 91302008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tumor necrosis factor Cytokine INHIBITOR DRUG LABEL DRUG LABEL

External reference:

IDSource
OP401G7OJC UNII
D00742 KEGG_DRUG
4021136 VUID
N0000148590 NUI
4021136 VANDF
C0717758 UMLSCUI
CHEBI:4875 CHEBI
CHEMBL1201572 ChEMBL_ID
DB00005 DRUGBANK_ID
D000068800 MESH_DESCRIPTOR_UI
7783 INN_ID
6789 IUPHAR_LIGAND_ID
2103480 RXNORM
13915 MMSL
33391 MMSL
7788 MMSL
d04365 MMSL
118259007 SNOMEDCT_US
387045004 SNOMEDCT_US
007673 NDDF
016975 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 50090-3531 SOLUTION 50 mg SUBCUTANEOUS BLA 32 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 50090-4490 SOLUTION 50 mg SUBCUTANEOUS BLA 29 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 50090-4590 SOLUTION 50 mg SUBCUTANEOUS BLA 32 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-010 SOLUTION 25 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-010 SOLUTION 25 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-021 SOLUTION 50 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-021 SOLUTION 50 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-032 SOLUTION 50 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-032 SOLUTION 50 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-044 SOLUTION 50 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-044 SOLUTION 50 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-055 SOLUTION 25 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-055 SOLUTION 25 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-435 SOLUTION 50 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-435 SOLUTION 50 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-445 SOLUTION 50 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-445 SOLUTION 50 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-446 SOLUTION 50 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-446 SOLUTION 50 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-455 SOLUTION 25 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-455 SOLUTION 25 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-456 SOLUTION 50 mg SUBCUTANEOUS BLA 33 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-456 SOLUTION 50 mg SUBCUTANEOUS BLA 33 sections
Eticovo HUMAN PRESCRIPTION DRUG LABEL 1 71202-003 INJECTION, SOLUTION 50 mg SUBCUTANEOUS BLA 29 sections
Eticovo HUMAN PRESCRIPTION DRUG LABEL 1 71202-004 INJECTION, SOLUTION 25 mg SUBCUTANEOUS BLA 29 sections