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favipiravir Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antivirals	4887	259793-96-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: favipiravir avigan T-705	A pyrazinecarboxamide derivative with activity against RNA viruses. Favipiravir is converted to the ribofuranosyltriphosphate derivative by host enzymes and selectively inhibits the influenza viral RNA-dependent RNA polymerase. Molecular weight: 157.10 Formula: C5H4FN3O2 CLOGP: 0.72 LIPINSKI: 0 HAC: 5 HDO: 2 TPSA: 89.10 ALOGS: -1.26 ROTB: 1

Molecule

Description

Molfile Inchi Smiles

Synonyms:

favipiravir
avigan
T-705

A pyrazinecarboxamide derivative with activity against RNA viruses. Favipiravir is converted to the ribofuranosyltriphosphate derivative by host enzymes and selectively inhibits the influenza viral RNA-dependent RNA polymerase.

Molecular weight: 157.10
Formula: C5H4FN3O2
CLOGP: 0.72
LIPINSKI: 0
HAC: 5
HDO: 2
TPSA: 89.10
ALOGS: -1.26
ROTB: 1

Drug dosage:

Dose	Unit	Route
1.60	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
March 24, 2014	PMDA	Toyama Chemical Co., Ltd.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

Source	Code	Description
ATC	J05AX27	ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Other antivirals
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000998	Antiviral Agents

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Influenza	indication	6142004	DOID:8469
Influenza caused by pandemic influenza virus	indication	719865001
Coronavirus infection	off-label use	186747009
Pregnancy, function	contraindication	289908002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.57	acidic
pKa2	11.39	acidic
pKa3	1.24	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Type	Activity value (-log[M])	Bioact source	MoA source
H1N1 subtype	Virus	EC50	6.13	SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
H2N2 subtype	Virus	EC50	6	SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
H3N2 subtype	Virus	EC50	5.74	SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
H1N5 subtype	Virus	EC50	5.35	SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
D09537	KEGG_DRUG
492405	PUBCHEM_CID
CHEBI:134722	CHEBI
CHEMBL221722	ChEMBL_ID
EW5GL2X7E0	UNII
8916	INN_ID
DB12466	DRUGBANK_ID
C462182	MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None