favipiravir Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antivirals 4887 259793-96-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • favipiravir
  • avigan
  • T-705
A pyrazinecarboxamide derivative with activity against RNA viruses. Favipiravir is converted to the ribofuranosyltriphosphate derivative by host enzymes and selectively inhibits the influenza viral RNA-dependent RNA polymerase.
  • Molecular weight: 157.10
  • Formula: C5H4FN3O2
  • CLOGP: 0.72
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 89.10
  • ALOGS: -1.26
  • ROTB: 1

Drug dosage:

DoseUnitRoute
1.60 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 24, 2014 PMDA Toyama Chemical Co., Ltd.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC J05AX27 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Other antivirals
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000998 Antiviral Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Influenza indication 6142004 DOID:8469
Influenza caused by pandemic influenza virus indication 719865001
Coronavirus infection off-label use 186747009
Pregnancy, function contraindication 289908002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.57 acidic
pKa2 11.39 acidic
pKa3 1.24 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
H1N1 subtype Virus EC50 6.13 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
H2N2 subtype Virus EC50 6 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
H3N2 subtype Virus EC50 5.74 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
H1N5 subtype Virus EC50 5.35 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D09537 KEGG_DRUG
492405 PUBCHEM_CID
CHEBI:134722 CHEBI
CHEMBL221722 ChEMBL_ID
EW5GL2X7E0 UNII
8916 INN_ID
DB12466 DRUGBANK_ID
C462182 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None