umifenovir 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antivirals 4868 131707-25-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • arbidole
  • umifenovir
  • arbidol
an antiviral agent. Although data is limited, in vitro activity against SARS-CoV-1 and SARS-CoV-2 has been reported. The drug has been included in COVID-19 treatment guidelines used in China and Russia.
  • Molecular weight: 477.42
  • Formula: C22H25BrN2O3S
  • CLOGP: 5.50
  • LIPINSKI: 1
  • HAC: 5
  • HDO: 1
  • TPSA: 54.70
  • ALOGS: -4.85
  • ROTB: 8

Drug dosage:

DoseUnitRoute
0.80 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 213.89 174.78 62 40 674400 62814520

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 271.78 120.12 79 42 419445 34537365

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 452.52 164.91 136 96 907079 78837077

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J05AX13 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Other antivirals

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Influenza indication 6142004 DOID:8469
Coronavirus infection off-label use 186747009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.81 acidic
pKa2 10.04 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain] Unclassified Kd 4.96 CHEMBL

External reference:

IDSource
93M09WW4RU UNII
D10558 KEGG_DRUG
C0254211 UMLSCUI
CHEBI:134730 CHEBI
75U PDB_CHEM_ID
CHEMBL1214598 ChEMBL_ID
131411 PUBCHEM_CID
DB13609 DRUGBANK_ID
9271 INN_ID
C086979 MESH_SUPPLEMENTAL_RECORD_UI
11089 IUPHAR_LIGAND_ID

Pharmaceutical products:

None