fluorometholone acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4647 3801-06-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fluorometholone acetate
  • oxylone acetate
  • eflone
  • Molecular weight: 418.51
  • Formula: C24H31FO5
  • CLOGP: 2.65
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 80.67
  • ALOGS: -4.82
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 11, 1986 FDA ALCON

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D018926 Anti-Allergic Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
CHEBI has role CHEBI:35472 anti-inflammatory drugs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Cyclitis indication 17657000
Iritis indication 65074000 DOID:1406
Iridocyclitis indication 77971008
Corneal abrasion indication 85848002
Corneal ulcer indication 91514001 DOID:8463
Uveitis indication 128473001 DOID:13141
Punctate keratopathy indication 246936005
Herpes zoster keratitis indication 397573005
Rosacea indication 398909004 DOID:8881
Allergic conjunctivitis indication 473460002 DOID:11204
Post-Op Ocular Inflammation indication
Otitis externa off-label use 3135009
Allergic otitis externa off-label use 405821001
Otitis Externa Eczema off-label use
Otitis Externa Seborrhea off-label use
Ocular hypertension contraindication 4210003 DOID:9282
Herpes simplex keratitis contraindication 9389005
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Severe myopia contraindication 34187009
Tuberculosis of eye contraindication 49107007
Diabetes mellitus contraindication 73211009 DOID:9351
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Eye infection contraindication 128351009
Bacterial infection of eye contraindication 128984004
Viral eye infection contraindication 312132001
Vaccinia keratitis contraindication 397552005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.48 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST Ki 8.35 WOMBAT-PK CHEMBL

External reference:

IDSource
D04221 KEGG_DRUG
4020951 VUID
N0000148429 NUI
4018212 VANDF
4020951 VANDF
CHEBI:31625 CHEBI
CHEMBL1201064 ChEMBL_ID
9I50C3I3OK UNII
240767 PUBCHEM_CID
9878 PUBCHEM_CID
DB00324 DRUGBANK_ID
216866 RXNORM
4120 MMSL
4743 MMSL
4744 MMSL
6193 MMSL
7403 MMSL
7420 MMSL
002194 NDDF
003646 NDDF
108851006 SNOMEDCT_US
2925007 SNOMEDCT_US
703087006 SNOMEDCT_US
C0724587 UMLSCUI
C0016351 UMLSCUI
D005469 MESH_DESCRIPTOR_UI
803 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Flarex HUMAN PRESCRIPTION DRUG LABEL 1 0065-0096 SUSPENSION/ DROPS 1 mg OPHTHALMIC NDA 18 sections
Flarex HUMAN PRESCRIPTION DRUG LABEL 1 71776-100 SUSPENSION/ DROPS 1 mg OPHTHALMIC NDA 18 sections