clocortolone pivalate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids not used as glucocorticosteroids 4606 34097-16-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clocortolone pivalate
  • clocortolone trimethylacetate
topical, anti-inflammatory glucocorticoid; structure
  • Molecular weight: 495.03
  • Formula: C27H36ClFO5
  • CLOGP: 4.57
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 80.67
  • ALOGS: -5.68
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 22, 1977 FDA PROMIUS PHARMA LLC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AB21 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:59683 antipruritic drugs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Lichen simplex chronicus indication 53891004
Granuloma annulare indication 65508009 DOID:3777
Pruritus ani indication 90446007
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Scalp psoriasis indication 238608008
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Primary cutaneous T-cell lymphoma indication 400122007
Telangiectasia disorder contraindication 247479008
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.07 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
D02287 KEGG_DRUG
4018552 VUID
N0000146872 NUI
4018552 VANDF
4019685 VANDF
CHEBI:59582 CHEBI
CHEMBL1200975 ChEMBL_ID
C007088 MESH_SUPPLEMENTAL_RECORD_UI
C004686 MESH_SUPPLEMENTAL_RECORD_UI
4828-27-7 SECONDARY_CAS_RN
QBL8IZH14X UNII
5282493 PUBCHEM_CID
146158995 PUBCHEM_CID
DB00838 DRUGBANK_ID
21249 RXNORM
213051 MMSL
4472 MMSL
002182 NDDF
004948 NDDF
17503004 SNOMEDCT_US
35406002 SNOMEDCT_US
413870009 SNOMEDCT_US
C0055900 UMLSCUI
C0055899 UMLSCUI
CHEMBL2106011 ChEMBL_ID
2113 INN_ID
N8ZUB7XE0H UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
clocortolone pivalate HUMAN PRESCRIPTION DRUG LABEL 1 43598-341 CREAM 0.00 g TOPICAL NDA authorized generic 11 sections
Clocortolone Pivalate HUMAN PRESCRIPTION DRUG LABEL 1 51672-4166 CREAM 0.00 g TOPICAL ANDA 21 sections
Clocortolone Pivalate HUMAN PRESCRIPTION DRUG LABEL 1 51672-4166 CREAM 0.00 g TOPICAL ANDA 21 sections
Clocortolone Pivalate Cream HUMAN PRESCRIPTION DRUG LABEL 1 66993-947 CREAM 1 mg TOPICAL NDA AUTHORIZED GENERIC 20 sections
Cloderm HUMAN PRESCRIPTION DRUG LABEL 1 67857-804 CREAM 0.00 g TOPICAL NDA 20 sections
Cloderm HUMAN PRESCRIPTION DRUG LABEL 1 71403-804 CREAM 1 mg TOPICAL NDA 20 sections