clocortolone pivalate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids not used as glucocorticosteroids 4606 34097-16-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clocortolone pivalate
  • clocortolone trimethylacetate
topical, anti-inflammatory glucocorticoid; structure
  • Molecular weight: 495.03
  • Formula: C27H36ClFO5
  • CLOGP: 4.57
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 80.67
  • ALOGS: -5.68
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 22, 1977 FDA PROMIUS PHARMA LLC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AB21 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
FDA EPC N0000175576 Corticosteroid
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Lichen simplex chronicus indication 53891004
Granuloma annulare indication 65508009 DOID:3777
Pruritus ani indication 90446007
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Scalp psoriasis indication 238608008
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Primary cutaneous T-cell lymphoma indication 400122007
Telangiectasia disorder contraindication 247479008
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.07 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
D02287 KEGG_DRUG
4018552 VUID
N0000146872 NUI
C0055900 UMLSCUI
N8ZUB7XE0H UNII
2113 INN_ID
4828-27-7 SECONDARY_CAS_RN
CHEMBL1200975 ChEMBL_ID
C004686 MESH_SUPPLEMENTAL_RECORD_UI
DB00838 DRUGBANK_ID
CHEMBL2106011 ChEMBL_ID
5282493 PUBCHEM_CID
C007088 MESH_SUPPLEMENTAL_RECORD_UI
17503004 SNOMEDCT_US
4018552 VANDF
4472 MMSL
21250 RXNORM
213051 MMSL
002182 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
clocortolone pivalate HUMAN PRESCRIPTION DRUG LABEL 1 43598-341 CREAM 0.00 g TOPICAL NDA authorized generic 11 sections
Clocortolone Pivalate HUMAN PRESCRIPTION DRUG LABEL 1 51672-4166 CREAM 0.00 g TOPICAL ANDA 11 sections
Clocortolone Pivalate Cream HUMAN PRESCRIPTION DRUG LABEL 1 66993-947 CREAM 1 mg TOPICAL NDA AUTHORIZED GENERIC 11 sections
Cloderm HUMAN PRESCRIPTION DRUG LABEL 1 67857-804 CREAM 0.00 g TOPICAL NDA 12 sections
Cloderm HUMAN PRESCRIPTION DRUG LABEL 1 71403-804 CREAM 1 mg TOPICAL NDA 11 sections