tonzonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4605 553-08-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tonzonium
  • thonzonium bromide
  • tonzonium bromide
  • thonzide
  • thonzonium
a surfactant with antifungal activity; also inhibits osteoclast formation
  • Molecular weight: 511.82
  • Formula: C32H55N4O
  • CLOGP: 6.43
  • LIPINSKI: 2
  • HAC: 5
  • HDO: 0
  • TPSA: 38.25
  • ALOGS: -7.48
  • ROTB: 22

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 17, 1962 FDA PAR STERILE PRODUCTS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009
Mastoidectomy Cavity Infections indication
Chronic purulent otitis media off-label use 38394007 DOID:14247
Herpes zoster auricularis contraindication 21954000 DOID:9210
Bullous myringitis contraindication 33528003 DOID:13791
Perforation of tympanic membrane contraindication 60442001
Herpes simplex contraindication 88594005 DOID:8566
Tuberculosis of ear contraindication 186269001
Viral ear infection contraindication 312137007
Fungal ear infection contraindication 312148000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.47 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Insulin-degrading enzyme Enzyme EC50 4.27 CHEMBL
Dual specificity tyrosine-phosphorylation-regulated kinase 1A Kinase AC50 5.03 CHEMBL

External reference:

IDSource
D02140 KEGG_DRUG
4018647 VUID
N0000146960 NUI
25466-36-8 SECONDARY_CAS_RN
4018647 VANDF
C0772395 UMLSCUI
CHEBI:94514 CHEBI
5456 PUBCHEM_CID
DB09552 DRUGBANK_ID
CHEMBL1200883 ChEMBL_ID
CHEMBL1201322 ChEMBL_ID
C000609116 MESH_SUPPLEMENTAL_RECORD_UI
221171 RXNORM
5576 MMSL
007523 NDDF
007524 NDDF
1559 INN_ID
JI2B19CR0R UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cortisporin-TC HUMAN PRESCRIPTION DRUG LABEL 4 54868-0564 SUSPENSION 0.50 mg AURICULAR (OTIC) NDA 22 sections
Cortisporin TC HUMAN PRESCRIPTION DRUG LABEL 4 63481-529 SUSPENSION 0.50 mg AURICULAR (OTIC) NDA 22 sections