flumetasone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 4548 2135-17-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • flumetasone
  • flucorticin
  • flumethason
  • fluorodexamethazone
  • flumethasone
An anti-inflammatory glucocorticoid used in veterinary practice.
  • Molecular weight: 410.46
  • Formula: C22H28F2O5
  • CLOGP: 1.83
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.68
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AB03 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC D07BB01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, moderately potent, combinations with antiseptics
ATC D07CB05 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, moderately potent, combinations with antibiotics
ATC D07XB01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, moderately potent, other combinations
ATC S02CA02 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
CHEBI has role CHEBI:35472 anti-inflammatory drugs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Lichen simplex chronicus indication 53891004
Granuloma annulare indication 65508009 DOID:3777
Pruritus ani indication 90446007
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Scalp psoriasis indication 238608008
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Primary cutaneous T-cell lymphoma indication 400122007
Hypopituitarism contraindication 74728003 DOID:9406
Skin striae contraindication 201066002
Telangiectasia disorder contraindication 247479008
Atrophoderma contraindication 399979006




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Pregnancy contraindication
Horses Pregnancy contraindication
Dogs Pregnancy contraindication
Dogs Otitis externa in conjunction with topical medication Indication
Dogs Allergic states Indication
Cats Acute and chronic dermatoses of varying etiology Indication
Horse Musculoskeletal conditions caused by inflammation, where permanent structural changes do not exist Indication
Horse Allergic states Indication
Dogs Shock and shock-like states Indication
Dogs Musculoskeletal conditions caused by inflammation of muscles or joints and accessory structures where permanent structural changes do not exist Indication
Dogs Acute and chronic dermatoses of varying etiology Indication

🐶 Veterinary products

ProductApplicantIngredients
Flucort Solution Zoetis Inc. 1
Flucort Tablets Zoetis Inc. 1
Anaprime Suspension Zoetis Inc. 1
Anaprime Ophthalmic Solution Zoetis Inc. 3
Anaprime Opthakote Ophthalmic Zoetis Inc. 3

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.06 acidic
pKa2 12.45 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D04208 KEGG_DRUG
N0000167461 NUI
CHEBI:34764 CHEBI
CHEMBL1201392 ChEMBL_ID
DB00663 DRUGBANK_ID
16490 PUBCHEM_CID
4458 RXNORM
004949 NDDF
116598007 SNOMEDCT_US
3037004 SNOMEDCT_US
D005443 MESH_DESCRIPTOR_UI
C0016294 UMLSCUI
1355 INN_ID
LR3CD8SX89 UNII

Pharmaceutical products:

None