potassium hydrogencarbonate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4520 298-14-6

Description:

MoleculeDescription

Synonyms:

  • potassium bicarbonate
  • carbonic acid monopotassium salt
  • monopotassium carbonate
  • potassium hydrogen carbonate
  • potassium hydrogencarbonate
Approved by EMA in combination with potassium citrate.
  • Molecular weight: 100.11
  • Formula: CHKO3
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 60.36
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
4 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 30, 2021 EMA Advicenne S.A.
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Burkholderia test positive 50.36 35.22 8 157 991 29573371

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Disease progression 30.78 28.90 18 576 141662 64356476

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A12BA04 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
POTASSIUM
Potassium
CHEBI has role CHEBI:35225 buffer compounds
CHEBI has role CHEBI:64049 pH control agents
CHEBI has role CHEBI:77971 food raising agent
CHEBI has role CHEBI:86328 anti-fungal agrichemical

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Heartburn indication 16331000
Hypokalemia indication 43339004
Indigestion indication 162031009
Gastroesophageal reflux disease indication 235595009 DOID:8534
Hypokalemia Prevention indication
Gastric Hypersecretory Conditions indication
Hiatal Hernia with Reflux Esophagitis indication
Multiple endocrine adenomas off-label use 60549007
Systemic mast cell disease off-label use 397016004 DOID:349
Stress-Related GI Mucosal Bleeding Prevention off-label use
Anuria contraindication 2472002 DOID:2983
Hyperkalemia contraindication 14140009
Complete atrioventricular block contraindication 27885002
Gastrointestinal ulcer contraindication 40845000
Chronic heart failure contraindication 48447003
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Hyperchloremia contraindication 74450001
Third degree burn injury contraindication 80247002
Oliguria contraindication 83128009
Hyporeninemic hypoaldosteronism contraindication 236464008
Edema contraindication 267038008
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02077 KEGG_DRUG
4017518 VUID
N0000145903 NUI
4017518 VANDF
CHEBI:81862 CHEBI
CHEMBL2106975 ChEMBL_ID
C026329 MESH_SUPPLEMENTAL_RECORD_UI
DB11098 DRUGBANK_ID
516893 PUBCHEM_CID
34296 RXNORM
1810 MMSL
5324 MMSL
d03600 MMSL
000745 NDDF
000765 NDDF
419980002 SNOMEDCT_US
77849004 SNOMEDCT_US
C0071751 UMLSCUI
HM5Z15LEBN UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
KLOR-Con/EF HUMAN PRESCRIPTION DRUG LABEL 1 0245-5326 TABLET, EFFERVESCENT 978 mg ORAL UNAPPROVED DRUG OTHER 20 sections
Alka-Seltzer Gold HUMAN OTC DRUG LABEL 3 0280-4100 TABLET, EFFERVESCENT 344 mg ORAL OTC monograph final 16 sections
K-EFFERVESCENT HUMAN PRESCRIPTION DRUG LABEL 1 0603-4170 TABLET, EFFERVESCENT 25 meq ORAL unapproved drug other 16 sections
TowerX Effervescent Potassium HUMAN PRESCRIPTION DRUG LABEL 1 50201-2400 TABLET, EFFERVESCENT 25 meq ORAL unapproved drug other 17 sections
Effer-K Orange HUMAN PRESCRIPTION DRUG LABEL 1 51801-001 TABLET, EFFERVESCENT 977.50 mg ORAL UNAPPROVED DRUG OTHER 21 sections
Effer-K Lemon Citrus HUMAN PRESCRIPTION DRUG LABEL 1 51801-005 TABLET, EFFERVESCENT 977.50 mg ORAL UNAPPROVED DRUG OTHER 21 sections
Effer-K Cherry Berry HUMAN PRESCRIPTION DRUG LABEL 1 51801-006 TABLET, EFFERVESCENT 977.50 mg ORAL UNAPPROVED DRUG OTHER 21 sections
Effer-K Unflavored HUMAN PRESCRIPTION DRUG LABEL 1 51801-007 TABLET, EFFERVESCENT 977.50 mg ORAL UNAPPROVED DRUG OTHER 21 sections
Effer-K 20 mEq Unflavored HUMAN PRESCRIPTION DRUG LABEL 1 51801-011 TABLET, EFFERVESCENT 782 mg ORAL UNAPPROVED DRUG OTHER 20 sections
Effer-K 20 mEq Orange Cream HUMAN PRESCRIPTION DRUG LABEL 1 51801-012 TABLET, EFFERVESCENT 782 mg ORAL UNAPPROVED DRUG OTHER 20 sections
Effer-K 10 mEq Unflavored HUMAN PRESCRIPTION DRUG LABEL 1 51801-013 TABLET, EFFERVESCENT 391 mg ORAL UNAPPROVED DRUG OTHER 20 sections
Effer-K 10 mEq Cherry Vanilla HUMAN PRESCRIPTION DRUG LABEL 1 51801-014 TABLET, EFFERVESCENT 391 mg ORAL UNAPPROVED DRUG OTHER 20 sections
Pleo Alkala Antacid HUMAN OTC DRUG LABEL 3 60681-6001 POWDER 117 g ORAL OTC monograph final 13 sections
Relief OTC antacid HUMAN OTC DRUG LABEL 3 69016-001 LIQUID 905 mg ORAL OTC monograph final 14 sections