alclometasone dipropionate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4493 66734-13-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alclometasone dipropionate
  • aclovate
  • Molecular weight: 521.05
  • Formula: C28H37ClO7
  • CLOGP: 3.91
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 1
  • TPSA: 106.97
  • ALOGS: -5.27
  • ROTB: 8

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 14, 1982 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AB10 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC S01BA10 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:59683 antipruritic drugs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Lichen simplex chronicus indication 53891004
Granuloma annulare indication 65508009 DOID:3777
Pruritus ani indication 90446007
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Scalp psoriasis indication 238608008
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Primary cutaneous T-cell lymphoma indication 400122007
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Skin striae contraindication 201066002
Telangiectasia disorder contraindication 247479008
Atrophoderma contraindication 399979006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.17 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
D01820 KEGG_DRUG
4019596 VUID
N0000147692 NUI
4018899 VANDF
4019596 VANDF
CHEBI:31184 CHEBI
CHEBI:53776 CHEBI
CHEMBL1200989 ChEMBL_ID
C021137 MESH_SUPPLEMENTAL_RECORD_UI
67452-97-5 SECONDARY_CAS_RN
S56PQL4N1V UNII
636374 PUBCHEM_CID
5311000 PUBCHEM_CID
DB00240 DRUGBANK_ID
108088 RXNORM
4129 MMSL
59682 MMSL
902 MMSL
002204 NDDF
004951 NDDF
116570009 SNOMEDCT_US
38684009 SNOMEDCT_US
395956000 SNOMEDCT_US
C0051113 UMLSCUI
C0360534 UMLSCUI
4616 INN_ID
136H45TB7B UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Alclometasone Dipropionate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0263 CREAM 0.50 mg TOPICAL ANDA 20 sections
Alclometasone Dipropionate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0264 OINTMENT 0.50 mg TOPICAL ANDA 20 sections
Alclometasone dipropionate HUMAN PRESCRIPTION DRUG LABEL 1 51672-1306 CREAM 0.50 mg TOPICAL ANDA 22 sections
Alclometasone Dipropionate HUMAN PRESCRIPTION DRUG LABEL 1 51672-1316 OINTMENT 0.50 mg TOPICAL ANDA 22 sections
Alclometasone Dipropionate HUMAN PRESCRIPTION DRUG LABEL 1 54868-2861 CREAM 0.50 mg TOPICAL ANDA 22 sections
Alclometasone Dipropionate HUMAN PRESCRIPTION DRUG LABEL 1 68462-299 OINTMENT 0.50 mg TOPICAL ANDA 22 sections
Alclometasone Dipropionate HUMAN PRESCRIPTION DRUG LABEL 1 68462-300 CREAM 0.50 mg TOPICAL ANDA 22 sections