diflorasone diacetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4485 33564-31-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dermaflor
  • diacort
  • diflorasone diacetate
topical corticosteroid has anti-inflammatory, anti-pruritic, and vasoconstrictive actions
  • Molecular weight: 494.53
  • Formula: C26H32F2O7
  • CLOGP: 2.90
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 106.97
  • ALOGS: -4.63
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 14, 1977 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AC10 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
CHEBI has role CHEBI:35472 anti-inflammatory drugs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Lichen simplex chronicus indication 53891004
Granuloma annulare indication 65508009 DOID:3777
Pruritus ani indication 90446007
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Scalp psoriasis indication 238608008
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Primary cutaneous T-cell lymphoma indication 400122007
Telangiectasia disorder contraindication 247479008
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.48 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST Ki 8.54 DRUG MATRIX CHEMBL
Progesterone receptor Transcription factor Ki 7.82 DRUG MATRIX

External reference:

IDSource
D01327 KEGG_DRUG
4018081 VUID
N0000179106 NUI
4018081 VANDF
4019719 VANDF
CHEBI:59750 CHEBI
CHEMBL1200545 ChEMBL_ID
C014477 MESH_SUPPLEMENTAL_RECORD_UI
7068 IUPHAR_LIGAND_ID
2557-49-5 SECONDARY_CAS_RN
7W2J09SCWX UNII
71414 PUBCHEM_CID
71415 PUBCHEM_CID
DB00223 DRUGBANK_ID
23033 RXNORM
11711 MMSL
4594 MMSL
002201 NDDF
004950 NDDF
38446009 SNOMEDCT_US
772931004 SNOMEDCT_US
7924004 SNOMEDCT_US
C0057992 UMLSCUI
C0304612 UMLSCUI
3314 INN_ID
T2DHJ9645W UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0243 OINTMENT 0.50 mg TOPICAL ANDA 20 sections
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0353 CREAM 0.50 mg TOPICAL ANDA 21 sections
ApexiCon E HUMAN PRESCRIPTION DRUG LABEL 1 10337-395 CREAM 0.50 mg TOPICAL ANDA 19 sections
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 51672-1295 OINTMENT 0.50 mg TOPICAL ANDA 21 sections
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 51672-1296 CREAM 0.50 mg TOPICAL ANDA 21 sections
psorcon HUMAN PRESCRIPTION DRUG LABEL 1 51672-5292 CREAM 5 mg TOPICAL ANDA 21 sections
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 52565-063 OINTMENT 0.50 mg TOPICAL ANDA 22 sections
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 61748-350 OINTMENT 0.50 mg TOPICAL ANDA 18 sections
Diflorasone Diacetate Human Prescription Drug Label 1 64980-124 OINTMENT 0.50 mg TOPICAL ANDA 17 sections
Diflorasone Diacetate Oint HUMAN PRESCRIPTION DRUG LABEL 1 70512-031 OINTMENT 0.50 mg TOPICAL ANDA 11 sections
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 71800-009 OINTMENT 0.50 mg TOPICAL ANDA 20 sections
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 72919-549 CREAM 0.50 mg TOPICAL ANDA 21 sections