butenafine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
squalene monooxygenase inhibitors, antifungals 444 101828-21-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • KP-363
  • KP 363
  • butenafine
  • butenafine hydrochloride
  • butenafine HCl
studied on experimental dermatophytosis
  • Molecular weight: 317.48
  • Formula: C23H27N
  • CLOGP: 6.74
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -6.62
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 18, 1996 FDA MYLAN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AE23 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Other antifungals for topical use
FDA CS M0002392 Benzylamines
CHEBI has role CHEBI:59285 squalene monooxygenase inhibitors
CHEBI has role CHEBI:86327 pharmaceutical fungicide
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
FDA EPC N0000175875 Benzylamine Antifungal

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tinea pedis indication 6020002 DOID:12403
Pityriasis versicolor indication 56454009 DOID:9060
Tinea corporis indication 84849002
Tinea cruris indication 399029005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 5.78 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 6.13 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.41 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 6.52 DRUG MATRIX
Acetylcholinesterase Enzyme IC50 5.16 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR Ki 5.86 DRUG MATRIX
Squalene epoxidase Enzyme INHIBITOR CHEMBL CHEMBL
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 6.81 DRUG MATRIX
Enoyl-[acyl-carrier-protein] reductase [NADH] Enzyme IC50 4.12 CHEMBL
Squalene monooxygenase Enzyme IC50 7.35 WOMBAT-PK

External reference:

IDSource
4024054 VUID
N0000022059 NUI
D01093 KEGG_DRUG
101827-46-7 SECONDARY_CAS_RN
236558 RXNORM
CHEBI:3238 CHEBI
CHEMBL990 ChEMBL_ID
CHEMBL1200397 ChEMBL_ID
C067594 MESH_SUPPLEMENTAL_RECORD_UI
6550 INN_ID
DB01091 DRUGBANK_ID
91Y494NL0X UNII
14815 MMSL
266673 MMSL
4313 MMSL
108923003 SNOMEDCT_US
108924009 SNOMEDCT_US
373449007 SNOMEDCT_US
C0107497 UMLSCUI
4021015 VANDF
4024054 VANDF
2484 PUBCHEM_CID
006293 NDDF
006294 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Athletes Foot HUMAN OTC DRUG LABEL 1 0363-2100 CREAM 10 mg TOPICAL ANDA 14 sections
Jock Itch HUMAN OTC DRUG LABEL 1 0363-2101 CREAM 10 mg TOPICAL ANDA 14 sections
MENTAX HUMAN PRESCRIPTION DRUG LABEL 1 0378-6151 CREAM 10 mg TOPICAL NDA 17 sections
Lotrimin Ultra HUMAN OTC DRUG LABEL 1 11523-0082 CREAM 1 g TOPICAL NDA 14 sections
Lotrimin Ultra HUMAN OTC DRUG LABEL 1 11523-0082 CREAM 1 g TOPICAL NDA 14 sections
Lotrimin UltraAthletes Foot HUMAN OTC DRUG LABEL 1 11523-4338 CREAM 1 g TOPICAL NDA 13 sections
Lotrimin UltraAthletes Foot HUMAN OTC DRUG LABEL 1 11523-4338 CREAM 1 g TOPICAL NDA 13 sections
Lotrimin UltraAthletes Foot HUMAN OTC DRUG LABEL 1 11523-4338 CREAM 1 g TOPICAL NDA 13 sections
Lotrimin UltraJock Itch HUMAN OTC DRUG LABEL 1 11523-4339 CREAM 1 g TOPICAL NDA 13 sections
Lotrimin UltraJock Itch HUMAN OTC DRUG LABEL 1 11523-4339 CREAM 1 g TOPICAL NDA 13 sections
Lotrimin UltraAntifungal HUMAN OTC DRUG LABEL 1 11523-7154 CREAM 10 mg TOPICAL NDA 14 sections
Lotrimin Ultra Jock ItchAntifungal HUMAN OTC DRUG LABEL 1 11523-7155 CREAM 10 mg TOPICAL NDA 14 sections
Athletes Foot HUMAN OTC DRUG LABEL 1 11673-016 CREAM 10 mg TOPICAL ANDA 14 sections
Athletes Foot HUMAN OTC DRUG LABEL 1 11822-2100 CREAM 10 mg TOPICAL ANDA 14 sections
Butenafine Hydrochloride HUMAN OTC DRUG LABEL 1 21130-965 CREAM 10 mg TOPICAL ANDA 14 sections
Butenafine Hydrochloride Athletes Foot HUMAN OTC DRUG LABEL 1 30142-210 CREAM 10 mg TOPICAL ANDA 14 sections
Athletes Foot HUMAN OTC DRUG LABEL 1 36800-049 CREAM 10 mg TOPICAL ANDA 14 sections
Athletes Foot Ultra HUMAN OTC DRUG LABEL 1 37808-013 CREAM 10 mg TOPICAL ANDA 14 sections
Butenafine Hydrochloride Jock Itch HUMAN OTC DRUG LABEL 1 49035-178 CREAM 10 mg TOPICAL ANDA 14 sections
Athletes Foot Ultra HUMAN OTC DRUG LABEL 1 49035-225 CREAM 10 mg TOPICAL ANDA 14 sections
Athletes Foot HUMAN OTC DRUG LABEL 1 51672-2100 CREAM 10 mg TOPICAL ANDA 14 sections
Jock Itch HUMAN OTC DRUG LABEL 1 51672-2101 CREAM 10 mg TOPICAL ANDA 14 sections
Athletes Foot HUMAN OTC DRUG LABEL 1 69842-986 CREAM 10 mg TOPICAL ANDA 14 sections
Athletes Foot HUMAN OTC DRUG LABEL 1 69842-986 CREAM 10 mg TOPICAL ANDA 14 sections
Butenafine Hydrochloride 1% HUMAN OTC DRUG LABEL 1 69842-989 CREAM 10 mg TOPICAL ANDA 14 sections
Butenafine Hydrochloride 1% HUMAN OTC DRUG LABEL 1 69842-989 CREAM 10 mg TOPICAL ANDA 14 sections