iodine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
radiopharmaceuticals, iodine-contained 4446 7553-56-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • iodine
A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
  • Molecular weight: 253.81
  • Formula: I2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 0
  • HDO: 0
  • TPSA:
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1349.71 14.95 660 6405 310027 63171930
Iodine allergy 82.92 14.95 19 7046 785 63481172
Lipoedema 41.47 14.95 9 7056 289 63481668
Fistula discharge 29.86 14.95 9 7056 1084 63480873
Spinal cord disorder 28.46 14.95 9 7056 1272 63480685
Oesophagitis 26.48 14.95 18 7047 14990 63466967
Vascular injury 26.24 14.95 8 7057 1002 63480955
Bladder spasm 25.51 14.95 9 7056 1779 63480178
Lymphoedema 25.47 14.95 16 7049 11676 63470281
Myelopathy 24.92 14.95 10 7055 2816 63479141
Drug ineffective 24.39 14.95 50 7015 1044715 62437242
Relapsing multiple sclerosis 22.30 14.95 5 7060 187 63481770
Urinary tract infection enterococcal 21.86 14.95 9 7056 2704 63479253
Infected lymphocele 21.40 14.95 5 7060 225 63481732
Endometrial cancer 20.36 14.95 9 7056 3216 63478741
Off label use 19.60 14.95 28 7037 674434 62807523
Vulval cancer 19.45 14.95 6 7059 781 63481176
Premature delivery 19.01 14.95 20 7045 30261 63451696
Venous angioma of brain 18.94 14.95 3 7062 15 63481942
Obstructive pancreatitis 18.38 14.95 5 7060 418 63481539
Incorrect product formulation administered 18.18 14.95 4 7061 137 63481820
Infusion related reaction 17.74 14.95 3 7062 245518 63236439
General physical health deterioration 16.86 14.95 55 7010 201347 63280610
Polyhydramnios 16.51 14.95 7 7058 2264 63479693
Urinary tract discomfort 16.18 14.95 5 7060 655 63481302
Procedural complication 15.90 14.95 9 7056 5430 63476527
Placental insufficiency 15.90 14.95 6 7059 1435 63480522
Allergy to metals 15.65 14.95 5 7060 730 63481227
Hypophagia 15.08 14.95 18 7047 31241 63450716
Gastric mucosa erythema 14.97 14.95 4 7061 312 63481645

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 261.47 21.23 122 2327 80407 34874075
Foetal exposure during pregnancy 47.85 21.23 31 2418 38070 34916412
Epispadias 37.87 21.23 7 2442 158 34954324
Dysmorphism 36.18 21.23 12 2437 3144 34951338
Iodine allergy 23.58 21.23 4 2445 54 34954428
Gastric bypass 22.44 21.23 5 2444 292 34954190
Drug tolerance 21.65 21.23 8 2441 2874 34951608
Dehydration 21.37 21.23 35 2414 129934 34824548

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1427.39 15.07 621 6039 298295 79439433
Iodine allergy 59.52 15.07 13 6647 578 79737150
Lipoedema 28.70 15.07 6 6654 216 79737512
Premature delivery 28.44 15.07 20 6640 23447 79714281
Vascular injury 27.68 15.07 8 6652 1113 79736615
Relapsing multiple sclerosis 25.23 15.07 5 6655 137 79737591
Vulval cancer 23.37 15.07 6 6654 536 79737192
Infected lymphocele 22.54 15.07 5 6655 239 79737489
Preternatural anus 20.50 15.07 4 6656 101 79737627
Maternal exposure during pregnancy 20.42 15.07 39 6621 136499 79601229
Polyhydramnios 20.35 15.07 7 6653 1713 79736015
Syndactyly 19.41 15.07 4 6656 134 79737594
Incorrect product formulation administered 19.21 15.07 4 6656 141 79737587
Placental insufficiency 19.05 15.07 6 6654 1117 79736611
Hyperchromic anaemia 18.42 15.07 4 6656 173 79737555
Diabetic foetopathy 18.17 15.07 3 6657 28 79737700
Fistula discharge 17.88 15.07 6 6654 1362 79736366
Contrast media allergy 17.74 15.07 7 6653 2515 79735213
Urinary tract discomfort 17.02 15.07 5 6655 736 79736992
Venous angioma of brain 16.74 15.07 3 6657 47 79737681
Spinal cord disorder 16.16 15.07 6 6654 1829 79735899
Endometrial cancer 15.39 15.07 6 6654 2088 79735640

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AG01 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Iodine products
ATC D08AG03 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Iodine products
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D018977 Micronutrients
MeSH PA D014131 Trace Elements
CHEBI has role CHEBI:33284 nutrients
CHEBI has role CHEBI:27027 trace elements
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Provision of therapeutic radionuclide indication 74385000
CD20 Positive Non-Hodgkin's Lymphoma indication
Neonatal thyrotoxicosis off-label use 13795004 DOID:12573
Thyrotoxic crisis off-label use 29028009 DOID:12837
Hyperthyroidism off-label use 34486009 DOID:7998
Lymphocutaneous sporotrichosis off-label use 87603003
Iodine deficiency off-label use 238121000
Thyroid Surgery off-label use
Thyroid Gland Radiation Protection off-label use
Bacterial septicemia contraindication 10001005 DOID:0040085
Hashimoto thyroiditis contraindication 21983002
Shock contraindication 27942005
Bronchitis contraindication 32398004 DOID:6132
Hypothyroidism contraindication 40930008 DOID:1459
Decreased respiratory function contraindication 80954004
Kidney disease contraindication 90708001 DOID:557
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Pulmonary tuberculosis contraindication 154283005 DOID:2957
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Hypocomplementemic urticarial vasculitis contraindication 239945009
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Breastfeeding (mother) contraindication 413712001
Denuded skin contraindication 418242004
Human Anti-Mouse Antibody (HAMA) Positive contraindication
Severe Bone Marrow Depression contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D00108 KEGG_DRUG
4017659 VUID
N0000146037 NUI
4017659 VANDF
C0021968 UMLSCUI
CHEBI:24859 CHEBI
CHEMBL1201225 ChEMBL_ID
DB05382 DRUGBANK_ID
9679TC07X4 UNII
807 PUBCHEM_CID
5933 RXNORM
4900 MMSL
d05776 MMSL
000852 NDDF
003150 NDDF
007599 NDDF
44588005 SNOMEDCT_US
767115003 SNOMEDCT_US
D007455 MESH_DESCRIPTOR_UI
I2I PDB_CHEM_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Iodine HUMAN OTC DRUG LABEL 3 0363-0088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
Iodine HUMAN OTC DRUG LABEL 3 0363-0088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 0395-1213 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 0395-1213 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
Humco Strong Iodine HUMAN PRESCRIPTION DRUG LABEL 2 0395-2775 LIQUID 50 mg ORAL unapproved drug other 12 sections
Humco Strong Iodine HUMAN PRESCRIPTION DRUG LABEL 2 0395-2775 LIQUID 50 mg ORAL unapproved drug other 12 sections
Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 0395-9118 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 0.15 mg ORAL unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 200 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 150 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 150 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 0.15 mg ORAL unapproved drug other 7 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 150 ug ORAL UNAPPROVED DRUG OTHER 6 sections
Iodine HUMAN OTC DRUG LABEL 3 0869-0088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
Iodine HUMAN OTC DRUG LABEL 3 0869-0088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
Iodine HUMAN OTC DRUG LABEL 3 0869-0088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
LUGOLS SOLUTION HUMAN PRESCRIPTION DRUG LABEL 1 10481-0111 LIQUID 0.40 g TOPICAL unapproved drug other 5 sections
Iodine HUMAN OTC DRUG LABEL 3 11344-088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
IODIUM HUMAN OTC DRUG LABEL 1 15631-0236 PELLET 3 [hp_X] ORAL unapproved homeopathic 13 sections
IODINE HUMAN OTC DRUG LABEL 2 16638-166 SOLUTION 0.50 g TOPICAL OTC monograph not final 9 sections
De La Cruz Tincture of Iodine HUMAN OTC DRUG LABEL 3 24286-1528 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
De La Cruz Tincture of Iodine HUMAN OTC DRUG LABEL 3 24286-1528 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
GNP Idoinde Tincture 2% Mild HUMAN OTC DRUG LABEL 3 24385-213 LIQUID 20 mg TOPICAL OTC monograph not final 14 sections
GNP Idoinde Tincture 2% Mild HUMAN OTC DRUG LABEL 3 24385-213 LIQUID 20 mg TOPICAL OTC monograph not final 14 sections
Iodine Tincture HUMAN OTC DRUG LABEL 2 30142-088 SOLUTION/ DROPS 20 mg TOPICAL OTC monograph not final 13 sections
Iodine Tincture HUMAN OTC DRUG LABEL 2 30142-088 SOLUTION/ DROPS 20 mg TOPICAL OTC monograph not final 13 sections
LEADER Mild Iodine HUMAN OTC DRUG LABEL 3 37205-022 TINCTURE 2 mg TOPICAL OTC monograph not final 11 sections
Iodine HUMAN OTC DRUG LABEL 3 41163-088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
Iodine HUMAN OTC DRUG LABEL 3 41163-088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections
Iodine HUMAN OTC DRUG LABEL 3 41163-088 LIQUID 20 mg TOPICAL OTC monograph not final 12 sections