tegafur 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
uridine derivatives used as antiviral agents and as antineoplastics 4398 17902-23-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tegafur
  • ftorafur
  • FT-207
  • florafur
  • futraful
Congener of FLUOROURACIL with comparable antineoplastic action. It has been suggested especially for the treatment of breast neoplasms.
  • Molecular weight: 200.17
  • Formula: C8H9FN2O3
  • CLOGP: -0.06
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 58.64
  • ALOGS: -1.16
  • ROTB: 1

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.62 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.95 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8.69 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
March 14, 2011 EMA Nordic Group BV

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Bone marrow failure 72.16 45.30 20 261 47932 64450519

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01BC03 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Pyrimidine analogues
ATC L01BC53 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Pyrimidine analogues
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D009676 Noxae

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Malignant tumor of stomach indication 363349007 DOID:10534




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.81 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01244 KEGG_DRUG
N0000167181 NUI
C0016778 UMLSCUI
CHEBI:32188 CHEBI
S7W PDB_CHEM_ID
CHEMBL20883 ChEMBL_ID
DB09256 DRUGBANK_ID
10513 IUPHAR_LIGAND_ID
4415 INN_ID
1548R74NSZ UNII
5386 PUBCHEM_CID
4582 RXNORM
007248 NDDF
395897006 SNOMEDCT_US
421459003 SNOMEDCT_US
D005641 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None