dapoxetine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives 4381 119356-77-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dapoxetine
  • priligy
  • dapoxetine hydrochloride
  • LY-210448
selective serotonin reuptake inhibitor (SSRI) that was designed specifically for premature ejaculation
  • Molecular weight: 305.42
  • Formula: C21H23NO
  • CLOGP: 5.34
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 12.47
  • ALOGS: -5.56
  • ROTB: 6

Drug dosage:

DoseUnitRoute
30 mg O

ADMET properties:

PropertyValueReference
S (Water solubility) 25.64 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G04BX14 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
UROLOGICALS
Other urologicals

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Premature ejaculation indication 44001008 DOID:13709




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.52 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR IC50 8.95 IUPHAR IUPHAR

External reference:

IDSource
C0215087 UMLSCUI
CHEBI:135962 CHEBI
D03649 KEGG_DRUG
CHEMBL2110900 ChEMBL_ID
DB04884 DRUGBANK_ID
C080598 MESH_SUPPLEMENTAL_RECORD_UI
7901 IUPHAR_LIGAND_ID
6834 INN_ID
129938-20-1 SECONDARY_CAS_RN
GB2433A4M3 UNII
71353 PUBCHEM_CID
015051 NDDF
015052 NDDF
702794006 SNOMEDCT_US
734472002 SNOMEDCT_US
CHEMBL2106574 ChEMBL_ID

Pharmaceutical products:

None