gentamicin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
aminoglycosides, antibiotics obtained from various Micromonospora 4265 1405-41-0

Description:

MoleculeDescription

Synonyms:

  • gentamicin sulfate
  • gentamicin
  • alcomicin
  • gentacin
  • gentamicine sulfate
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
  • Molecular weight: 1390.73
  • Formula: C60H123N15O21
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.24 g P

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 6.28 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.33 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 19, 1970 FDA SCHERING

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 583.40 14.27 542 17122 227516 50359944
Drug reaction with eosinophilia and systemic symptoms 243.63 14.27 141 17523 28283 50559177
Renal tubular necrosis 160.56 14.27 76 17588 10092 50577368
Multiple organ dysfunction syndrome 154.16 14.27 133 17531 50204 50537256
Toxic epidermal necrolysis 148.31 14.27 92 17572 20900 50566560
Peritonitis bacterial 112.77 14.27 47 17617 4614 50582846
Renal failure 108.06 14.27 158 17506 106475 50480985
Pathogen resistance 103.76 14.27 47 17617 5642 50581818
Septic shock 96.24 14.27 109 17555 57066 50530394
Ototoxicity 87.59 14.27 27 17637 1100 50586360
Anaphylactic reaction 85.82 14.27 100 17564 53955 50533505
Sepsis 82.36 14.27 158 17506 132767 50454693
Bartter's syndrome 82.00 14.27 13 17651 12 50587448
Peritonitis 80.40 14.27 56 17608 15430 50572030
Eosinophilia 75.43 14.27 58 17606 18594 50568866
Toxic skin eruption 73.64 14.27 47 17617 11204 50576256
Nephropathy toxic 71.85 14.27 41 17623 7988 50579472
Pyrexia 68.54 14.27 288 17376 379915 50207545
Shock haemorrhagic 62.55 14.27 38 17626 8306 50579154
Antibiotic level above therapeutic 61.71 14.27 15 17649 245 50587215
Abdominal discomfort 59.41 14.27 6 17658 231635 50355825
Tubulointerstitial nephritis 56.53 14.27 45 17619 15166 50572294
Drug resistance 53.71 14.27 48 17616 18941 50568519
Mucosal inflammation 51.93 14.27 67 17597 40075 50547385
Stevens-Johnson syndrome 51.89 14.27 50 17614 21702 50565758
Neutropenic sepsis 50.76 14.27 41 17623 14106 50573354
Drug intolerance 50.55 14.27 8 17656 219096 50368364
Joint swelling 50.19 14.27 12 17652 245274 50342186
Oliguria 48.08 14.27 32 17632 8184 50579276
Rheumatoid arthritis 47.63 14.27 7 17657 202543 50384917
Oropharyngeal oedema 46.89 14.27 12 17652 244 50587216
Endocarditis 45.48 14.27 26 17638 5081 50582379
Vestibular disorder 45.46 14.27 17 17647 1252 50586208
Headache 45.14 14.27 67 17597 506468 50080992
Fall 44.97 14.27 31 17633 334901 50252559
Metabolic alkalosis 44.91 14.27 21 17643 2710 50584750
Candida infection 43.25 14.27 47 17617 23476 50563984
Linear IgA disease 42.03 14.27 16 17648 1238 50586222
Intraventricular haemorrhage neonatal 41.81 14.27 10 17654 152 50587308
Arthritis bacterial 40.57 14.27 25 17639 5604 50581856
Nasopharyngitis 40.33 14.27 9 17655 192918 50394542
Systemic lupus erythematosus 37.76 14.27 3 17661 140619 50446841
Umbilical erythema 37.29 14.27 8 17656 72 50587388
Anuria 37.01 14.27 31 17633 11213 50576247
Abscess neck 36.68 14.27 12 17652 594 50586866
Drug interaction 36.43 14.27 152 17512 199469 50387991
Product dose omission issue 35.66 14.27 10 17654 183828 50403632
Mental status changes postoperative 35.60 14.27 9 17655 174 50587286
Renal injury 35.30 14.27 27 17637 8584 50578876
Fatigue 35.26 14.27 128 17536 707473 49879987
Excessive eye blinking 35.08 14.27 13 17651 933 50586527
Confusion postoperative 34.67 14.27 9 17655 194 50587266
Neutropenia 33.80 14.27 121 17543 147844 50439616
Liver abscess 33.77 14.27 17 17647 2576 50584884
Death neonatal 33.48 14.27 9 17655 223 50587237
Sepsis syndrome 33.22 14.27 12 17652 801 50586659
Disseminated intravascular coagulation 32.84 14.27 35 17629 17100 50570360
Pancytopenia 32.75 14.27 83 17581 83947 50503513
Noninfectious peritonitis 32.72 14.27 8 17656 134 50587326
Haemodynamic instability 32.54 14.27 25 17639 7999 50579461
Hyperchlorhydria 32.29 14.27 14 17650 1514 50585946
Renal impairment 31.88 14.27 77 17587 75584 50511876
Skin test positive 31.84 14.27 11 17653 644 50586816
Renal tubular disorder 31.81 14.27 16 17648 2421 50585039
Acute respiratory distress syndrome 31.75 14.27 38 17626 21061 50566399
Tendon necrosis 31.34 14.27 5 17659 5 50587455
Enterococcal infection 31.33 14.27 23 17641 6875 50580585
Contraindicated product administered 31.02 14.27 7 17657 148951 50438509
Deafness neurosensory 29.94 14.27 19 17645 4482 50582978
Arthropathy 29.87 14.27 9 17655 157897 50429563
Escherichia infection 29.64 14.27 27 17637 10914 50576546
Crystalluria 28.88 14.27 9 17655 380 50587080
Rash erythematous 28.72 14.27 47 17617 34805 50552655
Weight increased 27.98 14.27 18 17646 201873 50385587
Rash maculo-papular 27.68 14.27 40 17624 26601 50560859
Cholestasis 27.66 14.27 39 17625 25362 50562098
Procedural hypertension 27.37 14.27 8 17656 271 50587189
Therapeutic product effect decreased 27.13 14.27 7 17657 136043 50451417
Thrombocytopenia 27.12 14.27 102 17562 127571 50459889
Retinal infarction 27.05 14.27 6 17658 64 50587396
Lactic acidosis 26.17 14.27 44 17620 33311 50554149
Folate deficiency 26.00 14.27 13 17651 1942 50585518
Application site scab 25.61 14.27 7 17657 185 50587275
Blood phosphorus decreased 25.22 14.27 16 17648 3773 50583687
Lemierre syndrome 25.10 14.27 6 17658 91 50587369
Toxic shock syndrome streptococcal 24.86 14.27 6 17658 95 50587365
Premature baby 24.32 14.27 31 17633 18306 50569154
Pain 24.21 14.27 112 17552 578791 50008669
Puerperal pyrexia 24.18 14.27 5 17659 37 50587423
Peripheral swelling 23.91 14.27 22 17642 205914 50381546
Premature delivery 23.82 14.27 35 17629 23628 50563832
Injection site pain 23.55 14.27 5 17659 111019 50476441
Musculoskeletal stiffness 23.10 14.27 8 17656 128473 50458987
Agranulocytosis 22.02 14.27 32 17632 21389 50566071
Drug level increased 21.60 14.27 30 17634 19238 50568222
Morganella infection 21.55 14.27 8 17656 577 50586883
Guillain-Barre syndrome 21.45 14.27 14 17650 3463 50583997
Endocarditis bacterial 21.41 14.27 8 17656 588 50586872
Arthralgia 21.34 14.27 80 17584 438622 50148838
Foetal exposure during pregnancy 21.34 14.27 36 17628 27323 50560137
Macroglossia 20.88 14.27 8 17656 630 50586830
Blood creatinine increased 20.65 14.27 66 17598 76094 50511366
Tachycardia 20.59 14.27 79 17585 99684 50487776
Purpura 20.34 14.27 21 17643 9890 50577570
Kussmaul respiration 19.86 14.27 6 17658 228 50587232
Pain in extremity 19.77 14.27 41 17623 272824 50314636
Neurotoxicity 19.68 14.27 25 17639 14715 50572745
Therapeutic product effect incomplete 19.66 14.27 4 17660 91511 50495949
Inflammatory marker increased 19.51 14.27 16 17648 5618 50581842
Gastrointestinal haemorrhage 19.38 14.27 63 17601 73258 50514202
Hypoglossal nerve paresis 19.30 14.27 5 17659 107 50587353
Peritoneal dialysis complication 19.17 14.27 9 17655 1172 50586288
Anaphylactic shock 19.12 14.27 29 17635 20126 50567334
Discomfort 19.05 14.27 7 17657 108373 50479087
Septic embolus 18.98 14.27 8 17656 807 50586653
Tonsillitis bacterial 18.75 14.27 5 17659 120 50587340
Anal ulcer 18.58 14.27 7 17657 526 50586934
Infusion site necrosis 18.55 14.27 4 17660 37 50587423
Spinal subdural haematoma 18.52 14.27 5 17659 126 50587334
Nausea 18.35 14.27 158 17506 705240 49882220
Pancreatitis haemorrhagic 18.34 14.27 6 17658 297 50587163
Foetal heart rate decreased 17.95 14.27 5 17659 142 50587318
Haemolytic anaemia 17.84 14.27 19 17645 9273 50578187
Feeling abnormal 17.63 14.27 11 17653 125481 50461979
Exfoliative rash 17.63 14.27 11 17653 2519 50584941
Therapeutic drug monitoring analysis incorrectly performed 17.62 14.27 5 17659 152 50587308
Hydrops foetalis 17.57 14.27 6 17658 339 50587121
Necrosis 17.57 14.27 14 17650 4722 50582738
Human herpesvirus 6 infection 17.33 14.27 11 17653 2595 50584865
Shock 17.22 14.27 28 17636 20622 50566838
Urogenital disorder 17.17 14.27 4 17660 54 50587406
Drug eruption 17.02 14.27 30 17634 23576 50563884
Alopecia 16.77 14.27 38 17626 245009 50342451
Hypocalcaemia 16.71 14.27 32 17632 26784 50560676
Insomnia 16.63 14.27 22 17642 174843 50412617
Dermatitis exfoliative 16.56 14.27 14 17650 5128 50582332
Umbilical cord around neck 16.48 14.27 5 17659 193 50587267
Infusion related reaction 16.47 14.27 21 17643 169536 50417924
Staphylococcal sepsis 16.45 14.27 16 17648 7020 50580440
Neonatal cardiac failure 16.27 14.27 3 17661 11 50587449
Pyroglutamic acidosis 16.11 14.27 6 17658 437 50587023
Systemic infection 16.10 14.27 10 17654 2273 50585187
Haemodialysis 15.88 14.27 17 17647 8345 50579115
Hyperleukocytosis 15.84 14.27 6 17658 458 50587002
Staphylococcal infection 15.80 14.27 37 17627 35579 50551881
Device related infection 15.80 14.27 27 17637 20708 50566752
Geotrichum infection 15.76 14.27 6 17658 464 50586996
Bacterial disease carrier 15.74 14.27 7 17657 804 50586656
Immune reconstitution inflammatory syndrome 15.71 14.27 14 17650 5502 50581958
Sinusitis 15.67 14.27 22 17642 170536 50416924
Toxic shock syndrome 15.49 14.27 6 17658 486 50586974
Bronchopulmonary aspergillosis 15.42 14.27 16 17648 7576 50579884
Meconium in amniotic fluid 15.33 14.27 5 17659 245 50587215
Candida test positive 15.32 14.27 7 17657 857 50586603
Hypoperfusion 15.24 14.27 8 17656 1322 50586138
Muscle spasms 15.05 14.27 13 17651 125540 50461920
Sudden visual loss 14.91 14.27 3 17661 19 50587441
Renal cortical necrosis 14.81 14.27 4 17660 101 50587359
Epstein-Barr virus test positive 14.73 14.27 6 17658 555 50586905
Neonatal disorder 14.72 14.27 6 17658 556 50586904
Neuromuscular blockade 14.60 14.27 5 17659 285 50587175
Weight decreased 14.58 14.27 35 17629 221210 50366250
Hepatic cytolysis 14.56 14.27 16 17648 8087 50579373
Nephrocalcinosis 14.52 14.27 7 17657 967 50586493
Hypotonia neonatal 14.36 14.27 7 17657 990 50586470
Pulmonary necrosis 14.28 14.27 4 17660 116 50587344

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 468.92 14.20 693 17885 264574 29291375
Drug reaction with eosinophilia and systemic symptoms 211.44 14.20 160 18418 27832 29528117
Pathogen resistance 185.26 14.20 94 18484 8022 29547927
Renal tubular necrosis 164.76 14.20 106 18472 14209 29541740
Eosinophilia 113.28 14.20 101 18477 22060 29533889
Rash maculo-papular 96.00 14.20 96 18482 24193 29531756
Drug resistance 92.33 14.20 89 18489 21451 29534498
Crystalluria 89.36 14.20 25 18553 390 29555559
Endocarditis 80.10 14.20 48 18530 5668 29550281
Ototoxicity 76.99 14.20 31 18547 1534 29554415
Nephropathy toxic 75.68 14.20 59 18519 10697 29545252
Tubulointerstitial nephritis 68.35 14.20 69 18509 17574 29538375
Anaphylactic reaction 66.07 14.20 84 18494 27489 29528460
Spinal muscular atrophy 65.05 14.20 18 18560 269 29555680
Multiple organ dysfunction syndrome 64.24 14.20 130 18448 62986 29492963
Fatigue 61.77 14.20 65 18513 316756 29239193
Peritonitis bacterial 59.79 14.20 40 18538 5716 29550233
Pyrexia 59.57 14.20 345 18233 287277 29268672
Pneumococcal sepsis 56.28 14.20 21 18557 845 29555104
Klebsiella infection 51.02 14.20 40 18538 7309 29548640
Renal impairment 50.42 14.20 138 18440 81195 29474754
Septic shock 50.11 14.20 117 18461 62443 29493506
Vestibular disorder 48.83 14.20 20 18558 1034 29554915
Linear IgA disease 48.71 14.20 22 18556 1447 29554502
Renal failure 48.36 14.20 174 18404 118425 29437524
Toxic epidermal necrolysis 46.18 14.20 57 18521 18096 29537853
Respiratory tract infection bacterial 44.02 14.20 16 18562 597 29555352
Fall 43.48 14.20 29 18549 177149 29378800
Toxic skin eruption 43.08 14.20 41 18537 9716 29546233
Purpura 43.08 14.20 40 18538 9192 29546757
Antimicrobial susceptibility test resistant 43.03 14.20 13 18565 269 29555680
Death 42.74 14.20 95 18483 341989 29213960
Increased bronchial secretion 41.06 14.20 20 18558 1561 29554388
Cardiac valve vegetation 40.36 14.20 14 18564 455 29555494
Asthenia 39.83 14.20 46 18532 215204 29340745
Neonatal disorder 39.82 14.20 16 18562 787 29555162
Deafness neurosensory 39.66 14.20 23 18555 2555 29553394
Product dose omission issue 38.52 14.20 7 18571 96376 29459573
Auditory neuropathy spectrum disorder 38.24 14.20 6 18572 0 29555949
Sputum increased 37.31 14.20 20 18558 1907 29554042
Antibiotic level above therapeutic 37.29 14.20 11 18567 209 29555740
Acute generalised exanthematous pustulosis 35.79 14.20 29 18549 5554 29550395
Agranulocytosis 35.22 14.20 53 18525 20287 29535662
Sepsis 33.97 14.20 178 18400 142504 29413445
Cerebral ischaemia 33.17 14.20 28 18550 5675 29550274
Cholestasis 30.90 14.20 54 18524 23408 29532541
Peritonitis 30.61 14.20 42 18536 14782 29541167
Dizziness 30.48 14.20 45 18533 189639 29366310
Pulmonary haemorrhage 30.09 14.20 33 18545 9237 29546712
Ischaemic cerebral infarction 30.02 14.20 14 18564 991 29554958
Nausea 29.41 14.20 89 18489 289166 29266783
Chest X-ray abnormal 29.29 14.20 22 18556 3772 29552177
Infective aneurysm 28.37 14.20 11 18567 492 29555457
Disease complication 28.25 14.20 18 18560 2368 29553581
Motor neurone disease 28.04 14.20 10 18568 353 29555596
Hypoprothrombinaemia 27.70 14.20 10 18568 366 29555583
Metabolic disorder 27.58 14.20 21 18557 3674 29552275
Resuscitation 27.53 14.20 14 18564 1198 29554751
Mucormycosis 27.31 14.20 24 18554 5134 29550815
Necrotising colitis 26.92 14.20 13 18565 995 29554954
Haemodynamic instability 26.65 14.20 29 18549 8044 29547905
Nutritional condition abnormal 26.62 14.20 10 18568 410 29555539
Insomnia 25.38 14.20 12 18566 88749 29467200
Lower respiratory tract infection bacterial 25.17 14.20 9 18569 320 29555629
Listeriosis 25.01 14.20 12 18566 906 29555043
Infusion site induration 24.97 14.20 8 18570 202 29555747
Bradycardia neonatal 24.74 14.20 12 18566 928 29555021
Fungaemia 24.70 14.20 16 18562 2165 29553784
Stoma closure 24.68 14.20 7 18571 115 29555834
Headache 24.48 14.20 45 18533 173962 29381987
Thrombocytopenia 24.12 14.20 156 18422 134667 29421282
Brain injury 24.02 14.20 23 18555 5489 29550460
Sepsis neonatal 23.64 14.20 8 18570 241 29555708
Petechiae 23.56 14.20 28 18550 8543 29547406
Nosocomial infection 23.39 14.20 12 18566 1046 29554903
Hepatocellular injury 23.07 14.20 45 18533 21198 29534751
Bronchial disorder 22.34 14.20 12 18566 1149 29554800
ADAMTS13 activity decreased 22.25 14.20 6 18572 81 29555868
Pseudomembranous colitis 22.17 14.20 16 18562 2581 29553368
Lung consolidation 21.90 14.20 21 18557 5022 29550927
Lymphocyte morphology abnormal 21.85 14.20 9 18569 472 29555477
Acinetobacter infection 20.90 14.20 11 18567 1011 29554938
Arthralgia 20.63 14.20 35 18543 139582 29416367
Staphylococcal infection 20.51 14.20 52 18526 29188 29526761
Bacillus infection 20.34 14.20 7 18571 222 29555727
Intestinal ischaemia 20.30 14.20 23 18555 6669 29549280
Neonatal hypoxia 20.28 14.20 8 18570 375 29555574
Haemodialysis 20.24 14.20 28 18550 9926 29546023
Jarisch-Herxheimer reaction 20.17 14.20 8 18570 380 29555569
Aortic valve disease 20.04 14.20 11 18567 1099 29554850
Oliguria 20.02 14.20 24 18554 7388 29548561
Red blood cell schistocytes present 19.96 14.20 7 18571 235 29555714
Lymphadenectomy 19.96 14.20 7 18571 235 29555714
Intraventricular haemorrhage neonatal 19.74 14.20 7 18571 243 29555706
Clostridium difficile colitis 19.50 14.20 32 18546 13180 29542769
Blood alkaline phosphatase increased 19.39 14.20 50 18528 28356 29527593
Herpes zoster reactivation 19.21 14.20 7 18571 263 29555686
Stenotrophomonas test positive 19.14 14.20 7 18571 266 29555683
Drug ineffective 19.13 14.20 327 18251 362843 29193106
Haemorrhage neonatal 19.12 14.20 3 18575 0 29555949
Endocarditis candida 19.08 14.20 5 18573 60 29555889
Motor dysfunction 19.05 14.20 21 18557 5909 29550040
Hypotension 19.02 14.20 196 18382 194158 29361791
Hypersensitivity vasculitis 18.96 14.20 16 18562 3241 29552708
Antineutrophil cytoplasmic antibody 18.87 14.20 4 18574 17 29555932
Mast cell degranulation present 18.86 14.20 5 18573 63 29555886
Application site scab 18.71 14.20 5 18573 65 29555884
Eosinophilic pneumonia acute 18.61 14.20 8 18570 467 29555482
Chondrocalcinosis 18.59 14.20 7 18571 289 29555660
Respiratory distress 18.41 14.20 53 18525 32053 29523896
Aortic valve incompetence 18.31 14.20 19 18559 4994 29550955
Rash morbilliform 18.24 14.20 14 18564 2479 29553470
Premature baby 18.03 14.20 36 18542 17244 29538705
Condition aggravated 18.03 14.20 155 18423 146140 29409809
Rash erythematous 17.98 14.20 41 18537 21521 29534428
Cardiac valve abscess 17.87 14.20 4 18574 23 29555926
Haemophagocytic lymphohistiocytosis 17.65 14.20 27 18551 10477 29545472
Staphylococcal bacteraemia 17.63 14.20 22 18556 7057 29548892
Scrotal pain 17.52 14.20 9 18569 787 29555162
Aspergillus infection 17.50 14.20 27 18551 10554 29545395
Localised oedema 17.34 14.20 15 18563 3141 29552808
Cardiac arrest neonatal 17.19 14.20 4 18574 28 29555921
Nasopharyngitis 17.15 14.20 8 18570 59657 29496292
Stupor 17.05 14.20 14 18564 2730 29553219
Depression 17.04 14.20 17 18561 85130 29470819
Neuropathy peripheral 16.89 14.20 12 18566 71015 29484934
CD4 lymphocytes increased 16.76 14.20 6 18572 214 29555735
Injury 16.75 14.20 37 18541 19009 29536940
Cough 16.74 14.20 34 18544 126693 29429256
Dry gangrene 16.70 14.20 7 18571 384 29555565
Hyperaldosteronism 16.61 14.20 5 18573 102 29555847
Fixed eruption 16.59 14.20 10 18568 1192 29554757
Pain 16.49 14.20 54 18524 171378 29384571
Weight decreased 16.34 14.20 45 18533 150860 29405089
Trichosporon infection 16.33 14.20 8 18570 632 29555317
Blood creatinine increased 16.14 14.20 100 18478 85002 29470947
Cross sensitivity reaction 16.14 14.20 10 18568 1252 29554697
Coronary artery disease 16.03 14.20 4 18574 44186 29511763
Dermatitis contact 16.00 14.20 14 18564 2978 29552971
Extravasation 15.89 14.20 11 18567 1661 29554288
Arthritis reactive 15.86 14.20 6 18572 251 29555698
Application site erythema 15.82 14.20 12 18566 2087 29553862
Weight increased 15.69 14.20 15 18563 76652 29479297
Hypertransaminasaemia 15.63 14.20 15 18563 3591 29552358
Disseminated intravascular coagulation 15.57 14.20 37 18541 19943 29536006
Reticulocytosis 15.50 14.20 6 18572 267 29555682
Muscle spasms 15.47 14.20 11 18567 65071 29490878
Cerebellar atrophy 15.21 14.20 7 18571 481 29555468
Metabolic acidosis 15.08 14.20 55 18523 37607 29518342
Leukocyturia 15.03 14.20 7 18571 494 29555455
Renal tubular disorder 15.01 14.20 16 18562 4336 29551613
Pulmonary valve disease 14.99 14.20 6 18572 292 29555657
HIV associated nephropathy 14.99 14.20 6 18572 292 29555657
Cardio-respiratory arrest neonatal 14.97 14.20 3 18575 9 29555940
Clostridium difficile infection 14.93 14.20 32 18546 16109 29539840
Abdominal pain upper 14.90 14.20 10 18568 60983 29494966
Myeloma cast nephropathy 14.90 14.20 4 18574 53 29555896
Scoliosis 14.85 14.20 12 18566 2288 29553661
Diarrhoea 14.71 14.20 136 18442 332562 29223387
Arthritis infective 14.67 14.20 13 18565 2811 29553138
Arteritis 14.65 14.20 6 18572 310 29555639
Application site vesicles 14.51 14.20 7 18571 535 29555414
Malignant neoplasm progression 14.49 14.20 15 18563 73844 29482105
Fungal skin infection 14.41 14.20 12 18566 2386 29553563
Neonatal candida infection 14.30 14.20 3 18575 12 29555937
Chronic obstructive pulmonary disease 14.30 14.20 4 18574 40951 29514998
Neonatal tachypnoea 14.25 14.20 5 18573 168 29555781

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 1004.90 12.68 1146 29596 448094 64019896
Drug reaction with eosinophilia and systemic symptoms 428.49 12.68 286 30456 53931 64414059
Renal tubular necrosis 286.13 12.68 160 30582 21950 64446040
Pathogen resistance 246.11 12.68 120 30622 12423 64455567
Eosinophilia 189.49 12.68 152 30590 37924 64430066
Ototoxicity 163.73 12.68 58 30684 2665 64465325
Multiple organ dysfunction syndrome 160.70 12.68 219 30523 101194 64366796
Toxic epidermal necrolysis 155.08 12.68 134 30608 37032 64430958
Peritonitis bacterial 135.11 12.68 72 30670 8971 64459019
Anaphylactic reaction 131.71 12.68 163 30579 68501 64399489
Nephropathy toxic 130.09 12.68 89 30653 17425 64450565
Rash maculo-papular 122.89 12.68 131 30611 46895 64421095
Antibiotic level above therapeutic 118.59 12.68 32 30710 581 64467409
Crystalluria 117.52 12.68 34 30708 804 64467186
Septic shock 117.29 12.68 193 30549 105244 64362746
Pyrexia 116.57 12.68 550 30192 558094 63909896
Renal failure 115.15 12.68 262 30480 181426 64286564
Tubulointerstitial nephritis 112.16 12.68 103 30639 30806 64437184
Endocarditis 110.87 12.68 64 30678 9314 64458676
Drug resistance 104.71 12.68 105 30637 34997 64432993
Toxic skin eruption 102.37 12.68 80 30662 19204 64448786
Vestibular disorder 101.53 12.68 39 30703 2254 64465736
Completed suicide 93.42 12.68 3 30739 224411 64243579
Linear IgA disease 87.61 12.68 37 30705 2737 64465253
Bartter's syndrome 84.43 12.68 14 30728 12 64467978
Fall 81.45 12.68 49 30693 416777 64051213
Fatigue 78.44 12.68 149 30593 748581 63719409
Renal impairment 78.15 12.68 188 30554 134829 64333161
Sepsis 76.93 12.68 263 30479 230078 64237912
Peritonitis 76.74 12.68 76 30666 24947 64443043
Product dose omission issue 67.85 12.68 7 30735 194740 64273250
Headache 66.94 12.68 93 30649 529374 63938616
Purpura 65.55 12.68 59 30683 17187 64450803
Spinal muscular atrophy 64.72 12.68 17 30725 277 64467713
Drug intolerance 62.38 12.68 8 30734 187984 64280006
Deafness neurosensory 58.55 12.68 37 30705 6337 64461653
Rheumatoid arthritis 56.98 12.68 6 30736 164288 64303702
Joint swelling 53.44 12.68 18 30724 215364 64252626
Nasopharyngitis 52.98 12.68 14 30728 196059 64271931
Stevens-Johnson syndrome 52.72 12.68 73 30669 34176 64433814
Clostridium difficile infection 51.11 12.68 74 30668 36089 64431901
Drug abuse 51.01 12.68 3 30739 132371 64335619
Haemodynamic instability 50.82 12.68 48 30694 14864 64453126
Cardiac valve vegetation 50.64 12.68 18 30724 835 64467155
Cholestasis 49.65 12.68 82 30660 44790 64423200
Agranulocytosis 49.39 12.68 75 30667 38154 64429836
Weight increased 49.27 12.68 20 30722 213328 64254662
Pain 48.84 12.68 121 30621 553390 63914600
Pneumococcal sepsis 46.61 12.68 19 30723 1285 64466705
Renal injury 45.72 12.68 46 30696 15383 64452607
Noninfectious peritonitis 43.52 12.68 12 30730 237 64467753
Oropharyngeal oedema 43.23 12.68 12 30730 243 64467747
Shock haemorrhagic 42.47 12.68 46 30696 16745 64451245
Antimicrobial susceptibility test resistant 42.00 12.68 12 30730 271 64467719
Klebsiella infection 41.95 12.68 41 30701 13240 64454750
Metabolic alkalosis 41.68 12.68 25 30717 3903 64464087
Respiratory tract infection bacterial 40.05 12.68 15 30727 808 64467182
Acute generalised exanthematous pustulosis 39.99 12.68 41 30701 14017 64453973
Abdominal discomfort 39.09 12.68 19 30723 182303 64285687
Nausea 38.96 12.68 218 30524 785582 63682408
Renal tubular disorder 38.81 12.68 28 30714 5959 64462031
Arthralgia 37.94 12.68 98 30644 442162 64025828
Asthenia 37.37 12.68 94 30648 427950 64040040
Oliguria 36.99 12.68 40 30702 14536 64453454
Arthritis bacterial 36.24 12.68 30 30712 7809 64460181
Petechiae 35.33 12.68 44 30698 18582 64449408
Blood creatinine increased 34.40 12.68 142 30600 135640 64332350
Sepsis syndrome 33.64 12.68 15 30727 1266 64466724
Haemodialysis 33.45 12.68 41 30701 17036 64450954
Rash erythematous 32.82 12.68 72 30670 48561 64419429
Abdominal pain upper 32.16 12.68 22 30720 175008 64292982
Infective aneurysm 32.09 12.68 13 30729 865 64467125
Arthropathy 31.98 12.68 9 30733 120958 64347032
Pain in extremity 31.86 12.68 60 30682 303025 64164965
Anaphylactic shock 31.65 12.68 54 30688 30274 64437716
Therapeutic product effect decreased 31.60 12.68 8 30734 115343 64352647
Peripheral swelling 31.40 12.68 32 30710 209121 64258869
Aortic valve incompetence 30.76 12.68 28 30714 8273 64459717
Therapeutic product effect incomplete 30.71 12.68 6 30736 103476 64364514
Hypotension 30.44 12.68 296 30446 380678 64087312
Candida infection 30.26 12.68 54 30688 31365 64436625
Tachycardia 30.04 12.68 146 30596 149433 64318557
Enterococcal infection 29.96 12.68 35 30707 13831 64454159
Increased bronchial secretion 29.92 12.68 18 30724 2824 64465166
Tendon necrosis 29.78 12.68 5 30737 5 64467985
Hepatic cytolysis 29.59 12.68 35 30707 14014 64453976
Mental status changes postoperative 29.01 12.68 8 30734 158 64467832
Motor neurone disease 28.88 12.68 10 30732 429 64467561
Insomnia 28.87 12.68 31 30711 197805 64270185
Sinusitis 28.65 12.68 17 30725 145911 64322079
Anuria 28.55 12.68 40 30702 18924 64449066
Injection site pain 28.16 12.68 9 30733 111399 64356591
Blood alkaline phosphatase increased 27.95 12.68 74 30668 56205 64411785
Retinal infarction 27.58 12.68 8 30734 191 64467799
Device related infection 27.42 12.68 51 30691 30575 64437415
Intentional product use issue 27.33 12.68 6 30736 95358 64372632
Confusion postoperative 27.30 12.68 8 30734 198 64467792
Endocarditis bacterial 26.79 12.68 13 30729 1330 64466660
Disseminated intravascular coagulation 26.66 12.68 52 30690 32296 64435694
Skin test positive 26.60 12.68 12 30730 1041 64466949
Abscess neck 26.53 12.68 12 30730 1047 64466943
Lung consolidation 26.48 12.68 25 30717 7733 64460257
Septic embolus 26.23 12.68 14 30728 1748 64466242
Hyperaldosteronism 26.20 12.68 9 30733 377 64467613
Sputum increased 25.87 12.68 18 30724 3617 64464373
Stoma closure 25.79 12.68 7 30735 130 64467860
Staphylococcal infection 25.54 12.68 67 30675 50611 64417379
Asthma 25.33 12.68 7 30735 95218 64372772
Corneal oedema 25.08 12.68 15 30727 2328 64465662
Myeloma cast nephropathy 24.89 12.68 7 30735 149 64467841
Thrombocytopenia 24.75 12.68 187 30555 223614 64244376
Procedural hypertension 24.58 12.68 8 30734 283 64467707
Excessive eye blinking 24.54 12.68 12 30730 1248 64466742
Rash morbilliform 24.45 12.68 20 30722 5121 64462869
Face oedema 24.41 12.68 43 30699 24718 64443272
Hypoprothrombinaemia 24.08 12.68 10 30732 709 64467281
Hepatocellular injury 24.03 12.68 61 30681 45174 64422816
Pyroglutamic acidosis 23.85 12.68 10 30732 726 64467264
Oscillopsia 23.75 12.68 7 30735 177 64467813
Bacillus infection 23.72 12.68 10 30732 736 64467254
Endophthalmitis 23.70 12.68 20 30722 5345 64462645
Drug level increased 23.50 12.68 51 30691 34145 64433845
Endocarditis candida 23.43 12.68 6 30736 88 64467902
Disease complication 23.33 12.68 18 30724 4237 64463753
Hyperchlorhydria 23.20 12.68 13 30729 1786 64466204
Puerperal pyrexia 22.99 12.68 5 30737 34 64467956
Cerebral ischaemia 22.96 12.68 26 30716 9936 64458054
Fungaemia 22.94 12.68 17 30725 3768 64464222
Intervertebral discitis 22.66 12.68 17 30725 3840 64464150
Dizziness 22.52 12.68 117 30625 430046 64037944
Neutropenic sepsis 22.41 12.68 40 30702 23232 64444758
Depression 22.28 12.68 33 30709 183258 64284732
Acute respiratory distress syndrome 22.26 12.68 54 30688 38881 64429109
Lymphocyte morphology abnormal 22.22 12.68 10 30732 862 64467128
Lemierre syndrome 22.03 12.68 6 30736 113 64467877
Aortic valve disease 21.89 12.68 12 30730 1581 64466409
Muscle spasms 21.82 12.68 21 30721 141002 64326988
Resuscitation 21.62 12.68 13 30729 2038 64465952
Ischaemic cerebral infarction 21.50 12.68 13 30729 2059 64465931
Lower respiratory tract infection bacterial 21.32 12.68 9 30733 665 64467325
Suicide attempt 21.32 12.68 4 30738 71003 64396987
Brain injury 21.28 12.68 25 30717 9940 64458050
Nutritional condition abnormal 21.24 12.68 10 30732 956 64467034
Pseudomembranous colitis 21.05 12.68 18 30724 4898 64463092
Glossodynia 20.86 12.68 3 30739 64693 64403297
Chest discomfort 20.78 12.68 15 30727 116091 64351899
Blood culture positive 20.68 12.68 22 30720 7846 64460144
Musculoskeletal stiffness 20.68 12.68 17 30725 123189 64344801
Peritoneal dialysis complication 20.63 12.68 13 30729 2215 64465775
Haemophagocytic lymphohistiocytosis 20.58 12.68 33 30709 17576 64450414
Staphylococcal bacteraemia 20.50 12.68 25 30717 10330 64457660
Weight decreased 20.35 12.68 69 30673 285670 64182320
Macroglossia 20.25 12.68 10 30732 1062 64466928
ADAMTS13 activity decreased 20.23 12.68 6 30736 155 64467835
Mast cell degranulation present 20.23 12.68 5 30737 63 64467927
Influenza 20.09 12.68 13 30729 106518 64361472
Blood pressure increased 20.08 12.68 32 30710 172520 64295470
Neutropenia 20.00 12.68 188 30554 239436 64228554
Chest X-ray abnormal 19.94 12.68 20 30722 6661 64461329
Escherichia infection 19.93 12.68 30 30712 15138 64452852
Hepatitis 19.73 12.68 57 30685 45525 64422465
Learning disorder 19.67 12.68 8 30734 538 64467452
Acinetobacter infection 19.60 12.68 13 30729 2416 64465574
Psoriasis 19.58 12.68 5 30737 71698 64396292
Listeriosis 19.52 12.68 12 30730 1958 64466032
Suicidal ideation 19.45 12.68 4 30738 66538 64401452
Haematochezia 19.38 12.68 4 30738 66369 64401621
Chronic obstructive pulmonary disease 19.31 12.68 5 30737 71043 64396947
Premature delivery 19.26 12.68 33 30709 18556 64449434
Stenotrophomonas test positive 19.15 12.68 7 30735 352 64467638
Trichosporon infection 18.90 12.68 9 30733 883 64467107
Cough 18.88 12.68 77 30665 302071 64165919
Wrong technique in product usage process 18.79 12.68 4 30738 64970 64403020
Bronchial disorder 18.73 12.68 12 30730 2103 64465887
Geotrichum infection 18.65 12.68 9 30733 909 64467081
Feeling abnormal 18.33 12.68 22 30720 133580 64334410
Rash macular 18.22 12.68 37 30705 23648 64444342
Folate deficiency 18.09 12.68 13 30729 2750 64465240
Clostridium difficile colitis 18.02 12.68 40 30702 27183 64440807
Hypersensitivity vasculitis 17.94 12.68 19 30723 6742 64461248
Migraine 17.84 12.68 4 30738 62673 64405317
Mycobacterium abscessus infection 17.80 12.68 9 30733 1005 64466985
Metabolic acidosis 17.79 12.68 74 30668 70884 64397106
Infusion related reaction 17.75 12.68 32 30710 164435 64303555
Type IV hypersensitivity reaction 17.73 12.68 14 30728 3408 64464582
Hypopyon 17.68 12.68 9 30733 1020 64466970
Hypoglossal nerve paresis 17.62 12.68 5 30737 110 64467880
Metabolic disorder 17.59 12.68 20 30722 7677 64460313
Antineutrophil cytoplasmic antibody 17.51 12.68 4 30738 35 64467955
Pulmonary valve disease 17.34 12.68 6 30736 257 64467733
Dyspnoea 17.33 12.68 240 30502 718434 63749556
Exfoliative rash 17.29 12.68 14 30728 3532 64464458
Motor dysfunction 17.13 12.68 24 30718 11349 64456641
Serratia infection 17.02 12.68 10 30732 1503 64466487
CD4 lymphocytes increased 16.95 12.68 6 30736 275 64467715
Reticulocytosis 16.90 12.68 7 30735 493 64467497
Dyspnoea exertional 16.86 12.68 7 30735 73723 64394267
Systemic infection 16.85 12.68 15 30727 4306 64463684
Contraindicated product administered 16.74 12.68 16 30726 107813 64360177
Shock 16.72 12.68 48 30694 38192 64429798
Fluid retention 16.58 12.68 4 30738 59602 64408388
HIV associated nephropathy 16.55 12.68 6 30736 295 64467695
Infusion site necrosis 16.52 12.68 4 30738 46 64467944
Contusion 16.46 12.68 18 30724 113947 64354043
Infusion site induration 16.42 12.68 8 30734 825 64467165
Loss of personal independence in daily activities 16.37 12.68 7 30735 72447 64395543
Tonsillitis bacterial 16.28 12.68 5 30737 146 64467844
Toxicity to various agents 16.26 12.68 104 30638 363409 64104581
Red blood cell schistocytes present 16.26 12.68 7 30735 543 64467447
Staphylococcal sepsis 16.22 12.68 25 30717 12874 64455116
Respiratory alkalosis 16.14 12.68 14 30728 3883 64464107
Arthritis 16.11 12.68 10 30732 83804 64384186
Toxic shock syndrome 15.96 12.68 8 30734 878 64467112
Eosinophilic pneumonia acute 15.95 12.68 8 30734 879 64467111
Constipation 15.90 12.68 56 30686 229281 64238709
Dermatitis exfoliative 15.83 12.68 22 30720 10330 64457660
VIIIth nerve injury 15.79 12.68 3 30739 9 64467981
Deafness 15.72 12.68 30 30712 18329 64449661
Aspergillus infection 15.58 12.68 28 30714 16351 64451639
Pseudo-Bartter syndrome 15.54 12.68 4 30738 60 64467930
Arthritis reactive 15.52 12.68 6 30736 353 64467637
Drug eruption 15.45 12.68 45 30697 36091 64431899
Circulatory collapse 15.39 12.68 43 30699 33689 64434301
Cardiac failure congestive 15.39 12.68 24 30718 130556 64337434
Myalgia 15.28 12.68 33 30709 158584 64309406
Haematuria 15.11 12.68 63 30679 60408 64407582
Therapeutic drug monitoring analysis incorrectly performed 15.10 12.68 5 30737 187 64467803
Blood phosphorus decreased 15.08 12.68 16 30726 5689 64462301
Pseudomonas infection 15.04 12.68 29 30713 17854 64450136
Urogenital disorder 15.01 12.68 4 30738 69 64467921
Drug interaction 14.96 12.68 249 30493 361834 64106156
Kussmaul respiration 14.93 12.68 6 30736 391 64467599
Gait disturbance 14.83 12.68 38 30704 172117 64295873
Death 14.75 12.68 153 30589 482552 63985438
Haemolysis 14.74 12.68 22 30720 11017 64456973
Alopecia 14.72 12.68 36 30706 165654 64302336
Antibiotic level below therapeutic 14.70 12.68 4 30738 75 64467915
Status epilepticus 14.53 12.68 32 30710 21631 64446359
Nosocomial infection 14.50 12.68 11 30731 2526 64465464
Spinal subdural haematoma 14.45 12.68 5 30737 214 64467776
Chondrocalcinosis 14.36 12.68 7 30735 723 64467267
Pancytopenia 14.31 12.68 117 30625 143192 64324798
Swelling 14.09 12.68 35 30707 160183 64307807
Inappropriate schedule of product administration 13.97 12.68 14 30728 92272 64375718
Bronchitis 13.78 12.68 19 30723 108724 64359266
Fixed eruption 13.77 12.68 10 30732 2149 64465841
Dialysis 13.70 12.68 27 30715 16893 64451097
COVID-19 13.63 12.68 7 30735 65133 64402857
Clostridium test positive 13.55 12.68 13 30729 4102 64463888
Wound 13.53 12.68 10 30732 76467 64391523
Necrosis 13.45 12.68 18 30724 8153 64459837
Dry mouth 13.39 12.68 6 30736 60412 64407578
Hypocalcaemia 13.30 12.68 47 30695 41706 64426284
Auditory neuropathy spectrum disorder 13.15 12.68 3 30739 26 64467964
Back pain 13.09 12.68 68 30674 250103 64217887
Nephropathy 13.09 12.68 18 30724 8368 64459622
Hypoperfusion 13.03 12.68 10 30732 2336 64465654
Wound dehiscence 12.98 12.68 15 30727 5859 64462131
Hypokalaemia 12.98 12.68 101 30641 121802 64346188
Memory impairment 12.97 12.68 13 30729 85669 64382321
Bacteraemia 12.97 12.68 35 30707 26876 64441114
Osteoarthritis 12.97 12.68 7 30735 63329 64404661
Retinal toxicity 12.92 12.68 8 30734 1322 64466668
Clostridial infection 12.90 12.68 14 30728 5105 64462885
Enterobacter infection 12.79 12.68 12 30730 3684 64464306
Arterial angioplasty 12.77 12.68 3 30739 30 64467960
Immune reconstitution inflammatory syndrome 12.74 12.68 22 30720 12448 64455542
Blood cholesterol increased 12.73 12.68 4 30738 50062 64417928
Pancreatitis haemorrhagic 12.69 12.68 6 30736 579 64467411

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal exposure during pregnancy 55.70 26.62 8 565 11403 72702
Drug ineffective 30.73 26.62 34 539 883 83222
Blister 28.06 26.62 7 566 0 84105

Pharmacologic Action:

SourceCodeDescription
ATC D06AX07 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
ANTIBIOTICS FOR TOPICAL USE
Other antibiotics for topical use
ATC J01GB03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
AMINOGLYCOSIDE ANTIBACTERIALS
Other aminoglycosides
ATC S01AA11 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
ATC S02AA14 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
ATC S03AA06 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
ANTIINFECTIVES
Antiinfectives
FDA CS M0000946 Aminoglycosides
FDA EPC N0000175477 Aminoglycoside Antibacterial
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011500 Protein Synthesis Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Septicemia due to Escherichia coli indication 9323009
Bacterial septicemia indication 10001005 DOID:0040085
Infection due to Pseudomonas aeruginosa indication 11218009
Folliculitis indication 13600006 DOID:4409
Infection of skin AND/OR subcutaneous tissue indication 19824006
Pneumonia due to Pseudomonas indication 41381004
Peritonitis indication 48661000
Pneumonia due to Escherichia coli indication 51530003
Bacterial pneumonia indication 53084003 DOID:874
Blepharoconjunctivitis indication 68659002 DOID:2456
Infection due to Escherichia coli indication 71057007
Bacterial infection due to Serratia indication 71120004
Paronychia indication 71906005 DOID:13117
Rhinoscleroma indication 72409005 DOID:11336
Septicemia due to Serratia indication 82091000
Cholangitis indication 82403002 DOID:9446
Dacryocystitis indication 85777005 DOID:9938
Bacterial meningitis indication 95883001 DOID:9470
Infection of bone indication 111253001
Furunculosis indication 112650006
Infectious disease of abdomen indication 128070006
Bacterial conjunctivitis indication 128350005 DOID:9700
Bacterial infection of skin indication 128936008
Infection due to Enterobacteriaceae indication 128945009
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Proteus pneumonia indication 195888009
Sepsis of the newborn indication 206376005
Neonatal pneumonia indication 233619008
Neonatal meningitis indication 276674008
Proteus septicemia indication 300986008
Meibomianitis indication 309779001
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Infectious disorder of joint indication 363162000
Sepsis due to Pseudomonas indication 448813005
Sepsis due to Gram negative bacteria indication 449082003
Skin and Skin Structure Serratia Infection indication
Synergy for Escherichia Coli Meningitis indication
Synergy for Staphylococcal Infections indication
Pseudomonas Aeruginosa Meningitis indication
Synergy for Skin and Skin Structure Pseudomonas Aeruginosa Infection indication
Skin and Skin Structure Pseudomonas Aeruginosa Infection indication
Synergy for Staphylococcus Aureus Pneumonia indication
Gram-Negative Aerobic Bacillary Pneumonia indication
Enterobacter Pneumonia indication
Synergy for Klebsiella Meningitis indication
Burn Wound Infections indication
Complicated UTI with Pseudomonas Aeruginosa indication
Pseudomonas Aeruginosa Osteomyelitis indication
Synergy for Proteus Meningitis indication
Synergy for Group B Streptococcal Septicemia indication
Citrobacter Pneumonia indication
Synergy for Staphylococcal Endocarditis indication
Synergy for Pseudomonas Aeruginosa Joint Infection indication
Synergy for Pseudomonas Aeruginosa Osteomyelitis indication
Synergy for Neonatal Meningitis indication
Skin and Skin Structure Proteus Infection indication
Synergy for Staphylococcal Joint Infection indication
Citrobacter Septicemia indication
Pseudomonas Aeruginosa Joint Infection indication
Pseudomonas Aeruginosa Biliary Tract Infection indication
Skin and Skin Structure Citrobacter Infection indication
Synergy for Pseudomonas Aeruginosa Pneumonia indication
Synergy for Bacterial Meningitis indication
Synergy for Staphylococcus Skin and Skin Structure Infection indication
Complicated Urinary Tract Infections indication
Synergy for Pseudomonas Aeruginosa Meningitis indication
Synergy for Staphylococcal Septicemia indication
Complicated Bacterial Peritonitis indication
Synergy for Pseudomonas Aeruginosa Septicemia indication
Synergy for Citrobacter Meningitis indication
Synergy for Serratia Meningitis indication
Synergy for Enterobacter Meningitis indication
Klebsiella Septicemia indication
Necrotizing enterocolitis in fetus OR newborn off-label use 2707005
Pyrexia of unknown origin off-label use 7520000
Ecthyma gangrenosum off-label use 17732003
Enteric campylobacteriosis off-label use 18081009
Pseudotuberculosis off-label use 36753006
Plague off-label use 58750007 DOID:3482
Infection by Yersinia enterocolitica off-label use 80960004
Infection by Campylobacter fetus off-label use 111835002
Prevention of Perioperative Infection off-label use
Pseudomonas Respiratory Tract Infection in Cystic Fibrosis off-label use
Synergy for Prevention of Enterococcal Endocarditis off-label use
Listeria Monocytogenes Septicemia off-label use
Synergy for Enterococcal Endocarditis off-label use
Synergy for Listeria Monocytogenes Septicemia off-label use
Synergy for Enterococcal Infections off-label use
Synergy for Streptococcal Endocarditis off-label use
Ocular hypertension contraindication 4210003 DOID:9282
Hypocalcemia contraindication 5291005
Herpes simplex keratitis contraindication 9389005
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Parkinsonism contraindication 32798002
Dehydration contraindication 34095006
Severe myopia contraindication 34187009
Tuberculosis of eye contraindication 49107007
Tinnitus contraindication 60862001
Diabetes mellitus contraindication 73211009 DOID:9351
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Eye infection contraindication 128351009
Bacterial infection of eye contraindication 128984004
Pregnancy, function contraindication 289908002
Viral eye infection contraindication 312132001
Vaccinia keratitis contraindication 397552005
Vertigo contraindication 399153001
Denuded skin contraindication 418242004
Gentamicin Toxicity contraindication
Infant Botulism contraindication
Disorder of the 8th Cranial Nerve contraindication




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Cats Urinary tract infections Indication
Cats Respiratory tract infections Indication
Cats Skin and soft tissue infections Indication
Cats Supportive therapy for secondary bacterial infections associated with panleucopenia Indication
Cats Conjunctivitis Indication
Cattle Infectious bovine keratoconjunctivitis associated with Moraxella bovis Indication
Chickens Prevention of early mortality caused by Escherichia coli Indication
Chickens Prevention of early mortality caused by Salmonella typhimurium Indication
Chickens Prevention of early mortality caused by Pseudomonas aeruginosa Indication
Dogs External eye infections Indication
Dogs Acute and chronic otitis externa caused by bacteria Indication
Dogs Urinary tract infections Indication
Dogs Respiratory tract infections Indication
Dogs Skin and soft tissue infections Indication
Horses Uterus infections Indication
Horses Improving conception in mares with uterine infections Indication
Swine Dysentery associated with Brachyspira hyodysenteriae Indication
Swine PorcinEscherichia colibacillosis caused by Escherichia coli Indication
Turkeys Prevention of early mortality caused by Arizona paracolon infections Indication
Turkeys Reduction or elimination of Arizona hinshawii Indication
Turkeys Reduction or elimination of Salmonella st paul Indication
Turkeys Reduction or elimination of Mycoplasma meleagris Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Gentocin Durafilm Intervet Inc. 2
Gentocin Solution Intervet Inc. 1
Gentocin Solution Intervet Inc. 1
Gentocin Otic Solution Intervet Inc. 2
Garacin Intervet Inc. 1
Garasol Solution Intervet Inc. 1
Gentocin Ophthalmic Ointment Intervet Inc. 1
Gentocin Ophthalmic Solution Intervet Inc. 1
Garasol Injection Intervet Inc. 1
Garacin Piglet Injection Intervet Inc. 1
Topagen Ointment Intervet Inc. 2
Gentocin (Garacin) Pig Pump Oral Solution Intervet Inc. 1
Gentocin Pink Eye Spray Intervet Inc. 1
Gentocin Topical Spray Intervet Inc. 2
Garacin Soluble Powder Intervet Inc. 1
Gentamicin Sulfate Inj. Sol. Cronus Pharma Specialities India Private Limited 1
Otomax Intervet Inc. 3
Mometamax Otic Suspension Intervet Inc. 3
Easotic Virbac AH Inc. 3
Gentamicin Sulfate Solution 100 mg/ml Cronus Pharma Specialities India Private Limited 1
Gentamicin Sulfate Solution, Legacy Sterile Solution Huvepharma EOOD 1
Gentaglyde Solution Zoetis Inc. 1
Gentamex 100 Bimeda Animal Health Limited 1
GentaMax 100 Elanco US Inc. 1
Genta-Ject, Gentamicin Sulfate Injection Huvepharma EOOD 1
Gentamicin Sulfate Pig Pump Oral Solution Huvepharma EOOD 1
VET BETA-GEN Med-Pharmex Inc. 2
GEN-GARD Huvepharma EOOD 1
Betagen Topical Spray Med-Pharmex Inc. 2
GENTORAL Med-Pharmex Inc. 1
Gentasol Med-Pharmex Inc. 1
Tri-Otic Ointment Med-Pharmex Inc. 3
Vetro-Gen Veterinary Ophthalmic Ointment Dechra Veterinary Products LLC 1
Vetro-Max Fougera Pharmaceuticals Inc. 3
GBC Ointment Cronus Pharma Specialities India Private Limited 3
GB Topical Spray Dechra Veterinary Products LLC 2
Gentamicin Piglet Injection Sparhawk Laboratories Inc. 1
Gentamicin Sulfate Solution Sparhawk Laboratories Inc. 1
Gentamicin Sulfate Topical Spray First Priority Inc. 2
Gentamicin Topical Spray Sparhawk Laboratories Inc. 2
GentaMed-P for Poultry Injection Bimeda Animal Health Limited 1
GentaMed Bimeda Animal Health Limited 1
Mometavet Med-Pharmex Inc. 3
Gentamicin Sulfate Ophthalmic Solution Akorn Animal Health Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dihydrofolate reductase Enzyme IC50 4.74 CHEMBL
Dihydrofolate reductase Enzyme IC50 4.60 CHEMBL
Transient receptor potential cation channel subfamily A member 1 Ion channel GATING INHIBITOR IC50 5.20 IUPHAR

External reference:

IDSource
4019765 VUID
N0000179542 NUI
D01063 KEGG_DRUG
4018210 VANDF
4019765 VANDF
C3854019 UMLSCUI
CHEBI:17833 CHEBI
CHEMBL3039597 ChEMBL_ID
CHEMBL463809 ChEMBL_ID
CHEMBL3039594 ChEMBL_ID
D005839 MESH_DESCRIPTOR_UI
DB00798 DRUGBANK_ID
2427 IUPHAR_LIGAND_ID
1617 INN_ID
T6Z9V48IKG UNII
3467 PUBCHEM_CID
1596450 RXNORM
228599 MMSL
4779 MMSL
d00014 MMSL
002778 NDDF
004898 NDDF
2249001 SNOMEDCT_US
387321007 SNOMEDCT_US
57752001 SNOMEDCT_US
1403-66-3 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PRED-G HUMAN PRESCRIPTION DRUG LABEL 2 0023-0066 OINTMENT 3 mg OPHTHALMIC NDA 17 sections
PRED-G HUMAN PRESCRIPTION DRUG LABEL 2 0023-0106 SUSPENSION/ DROPS 3 mg OPHTHALMIC NDA 18 sections
Gentamicin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9128 INJECTION, SOLUTION 40 mg INTRAMUSCULAR ANDA 16 sections
Gentamicin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9129 INJECTION, SOLUTION 40 mg INTRAMUSCULAR ANDA 16 sections
Gentamicin sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0078 OINTMENT 1 mg TOPICAL ANDA 10 sections
Gentamicin Sulfate in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0338-0503 INJECTION, SOLUTION 80 mg INTRAVENOUS ANDA 23 sections
Gentamicin Sulfate in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0338-0505 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 23 sections
Gentamicin Sulfate in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0338-0507 INJECTION, SOLUTION 60 mg INTRAVENOUS ANDA 23 sections
Gentamicin Sulfate in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0338-0509 INJECTION, SOLUTION 80 mg INTRAVENOUS ANDA 23 sections
Gentamicin Sulfate in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0338-0511 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 23 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9865 INJECTION, SOLUTION 40 mg INTRAMUSCULAR ANDA 12 sections
Gentamicin HUMAN PRESCRIPTION DRUG LABEL 1 0404-9866 INJECTION, SOLUTION 40 mg INTRAMUSCULAR ANDA 13 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0409-1207 INJECTION, SOLUTION 40 mg INTRAMUSCULAR ANDA 17 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0409-1207 INJECTION, SOLUTION 40 mg INTRAMUSCULAR ANDA 17 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0682 OINTMENT 1 mg TOPICAL ANDA 9 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0682 OINTMENT 1 mg TOPICAL ANDA 9 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0683 CREAM 1 mg TOPICAL ANDA 9 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0683 CREAM 1 mg TOPICAL ANDA 9 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 13985-603 OINTMENT 3 mg OPHTHALMIC ANDA 18 sections
GENTAMICIN SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 16590-107 CREAM 1 mg TOPICAL ANDA 10 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 17478-283 SOLUTION/ DROPS 3 mg OPHTHALMIC ANDA 18 sections
Gentak HUMAN PRESCRIPTION DRUG LABEL 1 17478-284 OINTMENT 3 mg OPHTHALMIC ANDA 18 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 17478-826 SOLUTION/ DROPS 3 mg OPHTHALMIC ANDA 17 sections
Gentak HUMAN PRESCRIPTION DRUG LABEL 1 17478-827 OINTMENT 3 mg OPHTHALMIC ANDA 17 sections
GENTAMICIN SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 21695-187 SOLUTION 3 mg OPHTHALMIC ANDA 15 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 24208-580 SOLUTION/ DROPS 3 mg OPHTHALMIC ANDA 15 sections
GENTAMICIN SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 33261-604 SOLUTION/ DROPS 3 mg OPHTHALMIC ANDA 17 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 45802-046 OINTMENT 1 mg TOPICAL ANDA 11 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 45802-056 CREAM 1 mg TOPICAL ANDA 11 sections
Gentamicin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 45865-672 SOLUTION/ DROPS 3 mg OPHTHALMIC ANDA 15 sections