sodium monofluorophosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4252 10163-15-2

Description:

MoleculeDescription

Synonyms:

  • sodium monofluorophosphate
  • sodium phosphorofluoridate
  • disodium fluorophosphate
  • disodium monofluorophosphate
  • sodium fluorophosphate
inhibits Phosphorylas phosphatase irreversibly; RN given refers to parent cpd
  • Molecular weight: 143.95
  • Formula: FNa2O3P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 63.19
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 6, 1986 FDA CHESEBROUGH PONDS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 27.28 23.85 19 788 145654 63342561

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Respiratory tract infection bacterial 122.50 30.64 23 797 1759 34954352
Respiratory tract infection viral 120.59 30.64 24 796 2493 34953618
Cytokine release syndrome 83.73 30.64 28 792 22849 34933262
Fibrin D dimer increased 75.85 30.64 18 802 4226 34951885
Respiratory tract infection 71.59 30.64 24 796 19688 34936423
Thrombocytopenia 35.05 30.64 29 791 156218 34799893
COVID-19 32.42 30.64 21 799 77529 34878582
Pulmonary embolism 31.98 30.64 22 798 89724 34866387
C-reactive protein increased 31.18 30.64 18 802 54080 34902031

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Respiratory tract infection bacterial 122.93 24.10 23 1542 2054 79740769
Respiratory tract infection viral 112.11 24.10 24 1541 4235 79738588
Cytokine release syndrome 91.04 24.10 32 1533 35966 79706857
Fibrin D dimer increased 66.21 24.10 18 1547 8636 79734187
Respiratory tract infection 57.75 24.10 25 1540 48664 79694159
Platelet count decreased 40.09 24.10 32 1533 194632 79548191
Pulmonary embolism 37.01 24.10 29 1536 171625 79571198
Hypotension 30.25 24.10 40 1525 440277 79302546
Thrombocytopenia 29.73 24.10 31 1534 265228 79477595
Pyrexia 25.95 24.10 47 1518 678662 79064161

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A01AA02 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Caries prophylactic agents
ATC A12CD02 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
OTHER MINERAL SUPPLEMENTS
Fluoride
MeSH PA D002327 Cariostatic Agents
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:33282 bactericides

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Constipation contraindication 14760008 DOID:2089
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Osteolysis contraindication 203522001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D05864 KEGG_DRUG
C0142890 UMLSCUI
CHEBI:86431 CHEBI
CHEMBL1908359 ChEMBL_ID
DB09484 DRUGBANK_ID
C012980 MESH_SUPPLEMENTAL_RECORD_UI
C810JCZ56Q UNII
24266 PUBCHEM_CID
56501 RXNORM
41604 MMSL
NOCODE MMSL
004405 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
biotene HUMAN OTC DRUG LABEL 1 0135-0577 PASTE 1.40 mg ORAL OTC monograph final 12 sections
AquafreshKids Cavity Protection HUMAN OTC DRUG LABEL 1 0135-0619 PASTE 1.10 mg DENTAL OTC monograph final 11 sections
AquafreshKids Cavity Protection HUMAN OTC DRUG LABEL 1 0135-0619 PASTE 1.10 mg DENTAL OTC monograph final 11 sections
Ology Fluoride HUMAN OTC DRUG LABEL 1 0363-2008 PASTE 7.60 mg DENTAL OTC monograph final 8 sections
Truly Radiant Clean and Fresh HUMAN OTC DRUG LABEL 1 10237-668 PASTE, DENTIFRICE 0.83 mg DENTAL OTC monograph final 9 sections
Truly Radiant Clean and Fresh HUMAN OTC DRUG LABEL 1 10237-668 PASTE, DENTIFRICE 0.83 mg DENTAL OTC monograph final 9 sections
Dude Perfect Fluoride Toothpastes and Spinbrush Combo Pack HUMAN OTC DRUG LABEL 1 10237-673 PASTE, DENTIFRICE 1.10 mg DENTAL OTC monograph final 9 sections
Dude Perfect Fluoride Toothpastes and Spinbrush Combo Pack HUMAN OTC DRUG LABEL 1 10237-673 PASTE, DENTIFRICE 1.10 mg DENTAL OTC monograph final 9 sections
Rite Aid Brilliant White HUMAN OTC DRUG LABEL 1 11822-6032 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 9 sections
DENBLAN WHITENING FORMULA ANTI CAVITY FLUORIDE HUMAN OTC DRUG LABEL 1 16555-996 PASTE, DENTIFRICE 0.76 mL DENTAL OTC MONOGRAPH FINAL 10 sections
Lucky Super SoftAnti Cavity with Free Toothbrush HUMAN OTC DRUG LABEL 1 20276-551 PASTE, DENTIFRICE 7.60 mg DENTAL OTC monograph final 8 sections
Lucky Super SoftWhitening Anti Cavity with Free Toothbrush HUMAN OTC DRUG LABEL 1 20276-552 PASTE, DENTIFRICE 7.60 mg DENTAL OTC monograph final 8 sections
Lucky Super SoftWhitening Anti Cavity HUMAN OTC DRUG LABEL 1 20276-553 PASTE, DENTIFRICE 7.60 mg DENTAL OTC monograph final 8 sections
Lucky Super SoftAnti Cavity HUMAN OTC DRUG LABEL 1 20276-554 PASTE, DENTIFRICE 7.60 mg DENTAL OTC monograph final 8 sections
Kids Strawberry FTP HUMAN OTC DRUG LABEL 1 21130-417 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 8 sections
Kids Strawberry FTP HUMAN OTC DRUG LABEL 1 21130-417 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 8 sections
NBF Gingival HUMAN OTC DRUG LABEL 1 23636-1001 GEL 0.40 g DENTAL unapproved drug other 8 sections
ADVANCED FLUORIDE ANTICAVITY HUMAN OTC DRUG LABEL 1 29500-0819 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 9 sections
Advanced Whitening Anticavity Fluoride HUMAN OTC DRUG LABEL 1 29500-2238 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 9 sections
ADVANCED FLUORIDE ANTICAVITY HUMAN OTC DRUG LABEL 1 29500-9181 PASTE, DENTIFRICE 1000 mg DENTAL OTC monograph final 8 sections
Advanced Whitening Anticavity Fluoride HUMAN OTC DRUG LABEL 1 29500-9223 PASTE, DENTIFRICE 1000 mg DENTAL OTC monograph final 8 sections
Simple Truth Kids Flouride HUMAN OTC DRUG LABEL 1 30142-146 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 10 sections
Simple Truth Kids Flouride HUMAN OTC DRUG LABEL 1 30142-146 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 10 sections
Natural Adult Fluoride HUMAN OTC DRUG LABEL 1 30142-223 PASTE 0.76 g DENTAL OTC monograph final 8 sections
Natural Adult Fluoride HUMAN OTC DRUG LABEL 1 30142-223 PASTE 0.76 g DENTAL OTC monograph final 8 sections
Kroger CompanyRadiant White HUMAN OTC DRUG LABEL 1 30142-621 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 9 sections
Kroger CompanyRadiant White HUMAN OTC DRUG LABEL 1 30142-621 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 9 sections
Kroger CompanyRadiant White HUMAN OTC DRUG LABEL 1 30142-621 PASTE, DENTIFRICE 0.76 g DENTAL OTC monograph final 9 sections
CO Oh So Dazzling Sweet Mint HUMAN OTC DRUG LABEL 1 35000-135 PASTE, DENTIFRICE 1.50 mg DENTAL OTC MONOGRAPH FINAL 10 sections
COLGATE Great Regular Flavor HUMAN OTC DRUG LABEL 1 35000-257 PASTE, DENTIFRICE 1 mg DENTAL OTC MONOGRAPH FINAL 10 sections