alpha-tocopherol acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4195 58-95-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alpha-tocopherol acetate
  • Vitamin E acetate
  • (+)-alpha-tocopherol acetate
  • alfacol
  • contopheron
  • D-alpha-Tocopherol acetate
  • .alpha.-tocopherol acetate, dl-
  • .ALPHA.-TOCOPHEROL ACETATE, D-
  • .ALPHA.-TOCOPHEROL ACETATE
  • alpha-tocopherol acetate, dl-
  • tocopherol acetate
  • Molecular weight: 472.75
  • Formula: C31H52O3
  • CLOGP: 12
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 0
  • TPSA: 35.53
  • ALOGS: -8.21
  • ROTB: 14
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 18, 2000 FDA SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1544.08 9.89 3081 388811 117085 50096147
Systemic lupus erythematosus 1432.75 9.89 3281 388611 137341 50075891
Glossodynia 1233.03 9.89 2747 389145 112822 50100410
Rheumatoid arthritis 989.00 9.89 3629 388263 198921 50014311
Hand deformity 980.23 9.89 2302 389590 97897 50115335
Maternal exposure during pregnancy 885.84 9.89 2986 388906 156792 50056440
Arthropathy 866.56 9.89 2941 388951 154965 50058267
Alopecia 834.06 9.89 3930 387962 241117 49972115
Abdominal discomfort 818.44 9.89 3756 388136 227885 49985347
Wound 796.83 9.89 2202 389690 103592 50109640
Infusion related reaction 628.62 9.89 2790 389102 166767 50046465
Synovitis 623.64 9.89 2243 389649 121622 50091610
Pericarditis 608.32 9.89 1654 390238 77035 50136197
Anti-cyclic citrullinated peptide antibody positive 597.78 9.89 1535 390357 69052 50144180
Contraindicated product administered 584.06 9.89 2493 389399 146465 50066767
Discomfort 565.53 9.89 1986 389906 106394 50106838
Swelling 527.23 9.89 2998 388894 197874 50015358
Joint swelling 507.87 9.89 3444 388448 241842 49971390
Pain 480.25 9.89 6697 385195 572206 49641026
Product use issue 374.90 9.89 2205 389687 147270 50065962
Completed suicide 371.34 9.89 2007 389885 129882 50083350
Rheumatoid factor positive 364.32 9.89 1027 390865 48832 50164400
Duodenal ulcer perforation 344.57 9.89 951 390941 44660 50168572
Helicobacter infection 331.59 9.89 991 390901 48711 50164521
Arthralgia 308.29 9.89 4936 386956 433766 49779466
Hepatic enzyme increased 300.06 9.89 1956 389936 135424 50077808
Exposure during pregnancy 277.79 9.89 1745 390147 119270 50093962
Death 245.14 9.89 1496 390396 323883 49889349
Drug interaction 242.10 9.89 767 391125 198854 50014378
Febrile neutropenia 237.77 9.89 243 391649 97424 50115808
Hip arthroplasty 230.32 9.89 635 391257 29794 50183438
Musculoskeletal stiffness 216.56 9.89 1719 390173 126762 50086470
Drug intolerance 211.77 9.89 2610 389282 216494 49996738
Knee arthroplasty 210.63 9.89 684 391208 35162 50178070
Therapeutic product effect decreased 208.24 9.89 1781 390111 134269 50078963
Acute kidney injury 203.84 9.89 990 390902 227068 49986164
Treatment failure 201.40 9.89 1784 390108 135853 50077379
Diarrhoea 197.33 9.89 3290 388602 585186 49628046
Psoriatic arthropathy 175.40 9.89 776 391116 46256 50166976
Drug hypersensitivity 174.59 9.89 1182 390710 249828 49963404
Malignant neoplasm progression 174.46 9.89 162 391730 67962 50145270
Disease progression 170.82 9.89 300 391592 95566 50117666
Constipation 167.71 9.89 803 391089 184905 50028327
Nausea 166.39 9.89 4179 387713 701219 49512013
Nasopharyngitis 161.93 9.89 2240 389652 190687 50022545
Red blood cell sedimentation rate abnormal 157.88 9.89 374 391518 15969 50197263
Device expulsion 155.01 9.89 20 391872 28802 50184430
Neutropenia 147.89 9.89 616 391276 147349 50065883
Asthenia 146.63 9.89 1672 390220 317370 49895862
Dyspnoea 141.34 9.89 3199 388693 544409 49668823
C-reactive protein abnormal 140.86 9.89 505 391387 27304 50185928
Alcohol interaction 137.94 9.89 122 391770 2022 50211210
Bradycardia 133.51 9.89 182 391710 64244 50148988
Hypersensitivity 132.59 9.89 2372 389520 212789 50000443
Rheumatic fever 131.62 9.89 356 391536 16511 50196721
Hyponatraemia 129.78 9.89 351 391541 95788 50117444
Impaired healing 129.38 9.89 955 390937 68831 50144401
Swollen joint count increased 127.37 9.89 325 391567 14548 50198684
Sickle cell anaemia with crisis 126.75 9.89 166 391726 4377 50208855
Cardiac failure 123.97 9.89 251 391641 75789 50137443
Dizziness 118.76 9.89 1927 389965 344442 49868790
Anxiety 117.65 9.89 848 391044 176758 50036474
Tremor 116.88 9.89 475 391417 114428 50098804
Renal failure 108.34 9.89 441 391451 106192 50107040
Multiple sclerosis relapse 106.68 9.89 105 391787 42859 50170373
Pregnancy 104.26 9.89 480 391412 29097 50184135
Drug reaction with eosinophilia and systemic symptoms 100.59 9.89 47 391845 28377 50184855
Depressed level of consciousness 99.56 9.89 155 391737 51798 50161434
Drug ineffective 98.97 9.89 7488 384404 811845 49401387
Sedation 98.85 9.89 57 391835 30553 50182679
Vomiting 96.59 9.89 2774 389118 457984 49755248
Live birth 94.48 9.89 311 391581 16097 50197135
Neoplasm progression 93.16 9.89 55 391837 29102 50184130
Sleep disorder due to general medical condition, insomnia type 92.04 9.89 484 391408 30963 50182269
Anaemia 90.63 9.89 1392 390500 251064 49962168
Muscle injury 90.60 9.89 544 391348 36567 50176665
Lactic acidosis 90.60 9.89 75 391817 33280 50179952
Abortion spontaneous 89.35 9.89 592 391300 41180 50172052
Folliculitis 88.24 9.89 563 391329 38662 50174570
Neuropathy peripheral 86.89 9.89 419 391473 96338 50116894
Psoriasis 85.18 9.89 863 391029 68137 50145095
Insomnia 82.30 9.89 911 390981 173954 50039278
Arthritis 82.26 9.89 1030 390862 85691 50127541
Product quality issue 80.63 9.89 72 391820 30786 50182446
Lower respiratory tract infection 80.40 9.89 1107 390785 94094 50119138
Myalgia 79.67 9.89 599 391293 123720 50089512
Renal impairment 78.67 9.89 310 391582 75351 50137881
Hypotension 78.28 9.89 1317 390575 234152 49979080
Hyperhidrosis 76.99 9.89 393 391499 89033 50124199
Blister 75.31 9.89 1001 390891 84417 50128815
Osteoarthritis 74.84 9.89 837 391055 67769 50145463
Rash 74.06 9.89 4117 387775 433354 49779878
Syncope 74.00 9.89 480 391412 102522 50110710
Palmar-plantar erythrodysaesthesia syndrome 73.04 9.89 32 391860 20066 50193166
Fatigue 72.49 9.89 6388 385504 701213 49512019
Asthma 71.70 9.89 402 391490 88935 50124297
Thrombocytopenia 71.39 9.89 638 391254 127035 50086197
Cardiac failure congestive 70.30 9.89 375 391517 84007 50129225
Injection site erythema 69.34 9.89 886 391006 74050 50139182
Rhabdomyolysis 68.69 9.89 123 391769 38904 50174328
Respiratory failure 67.50 9.89 421 391471 90760 50122472
Hyperglycaemia 67.50 9.89 111 391781 36294 50176938
No adverse event 67.42 9.89 97 391795 33481 50179751
Muscle spasms 67.34 9.89 634 391258 124919 50088313
Electrocardiogram QT prolonged 66.61 9.89 194 391698 51692 50161540
Feeling abnormal 66.32 9.89 636 391256 124856 50088376
Blood pressure fluctuation 66.23 9.89 490 391402 35333 50177899
Joint effusion 64.69 9.89 235 391657 12786 50200446
Irritable bowel syndrome 64.26 9.89 645 391247 50796 50162436
Drug resistance 63.28 9.89 34 391858 18955 50194277
Pulmonary embolism 61.89 9.89 497 391395 101207 50112025
Caesarean section 61.31 9.89 262 391630 15377 50197855
Disability assessment scale score increased 60.94 9.89 83 391809 2275 50210957
Juvenile idiopathic arthritis 60.70 9.89 92 391800 2787 50210445
Injection site pruritus 60.66 9.89 527 391365 39884 50173348
Blood glucose increased 60.51 9.89 315 391577 71009 50142223
Fluid retention 60.31 9.89 196 391696 50453 50162779
Hepatic function abnormal 60.26 9.89 100 391792 32581 50180651
Alcohol poisoning 60.16 9.89 72 391820 1728 50211504
Urticaria 60.13 9.89 677 391215 128884 50084348
Cardio-respiratory arrest 59.46 9.89 659 391233 53233 50159999
Dehydration 59.37 9.89 827 391065 151622 50061610
Vision blurred 59.32 9.89 361 391531 78286 50134946
Cognitive disorder 58.83 9.89 162 391730 43961 50169271
Cholestasis 58.65 9.89 66 391826 25335 50187897
Decreased appetite 58.49 9.89 1150 390742 199773 50013459
Condition aggravated 57.94 9.89 2834 389058 294224 49919008
Hypoxia 57.35 9.89 203 391689 50920 50162312
Diabetic ketoacidosis 56.69 9.89 34 391858 17838 50195394
Suspected suicide 56.59 9.89 127 391765 5230 50208002
Basal cell carcinoma 56.13 9.89 341 391551 23015 50190217
Foetal exposure during pregnancy 55.67 9.89 383 391509 26976 50186256
Balance disorder 54.83 9.89 321 391571 70269 50142963
Orthostatic hypotension 54.55 9.89 90 391802 29391 50183841
Cytomegalovirus infection 54.45 9.89 36 391856 17926 50195306
White blood cell count decreased 54.13 9.89 610 391282 116112 50097120
Joint laxity 53.96 9.89 79 391813 2319 50210913
Chest discomfort 53.74 9.89 459 391433 92263 50120969
Red blood cell sedimentation rate increased 53.60 9.89 401 391491 29015 50184217
Neutrophil count decreased 53.50 9.89 180 391712 45846 50167386
Anaphylactic reaction 53.35 9.89 226 391666 53829 50159403
Hypoglycaemia 52.89 9.89 224 391668 53357 50159875
Muscle spasticity 52.69 9.89 34 391858 17150 50196082
Sedation complication 52.56 9.89 4 391888 8762 50204470
Alcohol use 51.22 9.89 70 391822 1925 50211307
Pulmonary arterial hypertension 51.20 9.89 49 391843 20270 50192962
Foot deformity 51.04 9.89 288 391604 18922 50194310
Respiratory disorder 50.76 9.89 103 391789 31084 50182148
Emotional distress 50.75 9.89 90 391802 28573 50184659
Product use in unapproved indication 50.71 9.89 613 391279 115206 50098026
Hyperkalaemia 50.64 9.89 196 391696 47893 50165339
Hospitalisation 50.11 9.89 314 391578 67623 50145609
Multiple organ dysfunction syndrome 49.96 9.89 210 391682 50127 50163105
Metastases to bone 49.44 9.89 40 391852 17955 50195277
Blood pressure diastolic abnormal 49.12 9.89 172 391720 9189 50204043
Dyspnoea exertional 48.85 9.89 217 391675 51016 50162216
Encephalopathy 48.60 9.89 119 391773 33592 50179640
Leukopenia 48.33 9.89 315 391577 67213 50146019
Serotonin syndrome 48.04 9.89 73 391819 24640 50188592
Ill-defined disorder 47.96 9.89 640 391252 54014 50159218
Osteonecrosis of jaw 47.53 9.89 114 391778 32412 50180820
Hepatocellular injury 47.28 9.89 80 391812 25867 50187365
Premature labour 47.12 9.89 195 391697 11281 50201951
Sinusitis 47.05 9.89 1688 390204 168870 50044362
Injection site swelling 46.62 9.89 512 391380 41261 50171971
Contusion 46.29 9.89 1167 390725 111016 50102216
Myocardial infarction 45.84 9.89 454 391438 88573 50124659
Injection site reaction 44.78 9.89 588 391304 49444 50163788
Hypokalaemia 44.77 9.89 450 391442 87542 50125690
Grip strength decreased 44.42 9.89 199 391693 11922 50201310
Gestational diabetes 44.33 9.89 143 391749 7322 50205910
Osteoporosis 44.24 9.89 537 391355 44342 50168890
Deep vein thrombosis 44.23 9.89 359 391533 72945 50140287
Platelet count decreased 44.14 9.89 533 391359 100193 50113039
Intentional product use issue 44.13 9.89 839 391053 76079 50137153
Angioedema 44.02 9.89 147 391745 37529 50175703
Blood cholesterol increased 43.76 9.89 635 391257 54580 50158652
Bone erosion 43.67 9.89 193 391699 11494 50201738
Drug abuse 43.45 9.89 678 391214 59168 50154064
Tachycardia 43.30 9.89 529 391363 99234 50113998
Fibromyalgia 42.96 9.89 535 391357 44443 50168789
Disturbance in attention 42.70 9.89 113 391779 31073 50182159
Maternal drugs affecting foetus 42.49 9.89 110 391782 4967 50208265
Type 2 diabetes mellitus 42.43 9.89 430 391462 33945 50179287
Pain in jaw 42.17 9.89 154 391738 38274 50174958
Blood pressure systolic abnormal 41.65 9.89 143 391749 7563 50205669
Creatinine renal clearance decreased 41.49 9.89 20 391872 11861 50201371
Neck deformity 41.41 9.89 63 391829 1915 50211317
Speech disorder 41.33 9.89 139 391753 35409 50177823
Cardiac arrest 41.24 9.89 431 391461 83220 50130012
Blood pressure systolic increased 41.19 9.89 438 391454 35011 50178221
Bone pain 40.95 9.89 207 391685 47022 50166210
Chest pain 40.76 9.89 1050 390842 175832 50037400
Hallucination 40.74 9.89 204 391688 46453 50166779
Multiple fractures 40.50 9.89 128 391764 6483 50206749
Hepatic failure 40.50 9.89 122 391770 32161 50181071
Injection site pain 40.36 9.89 1136 390756 109888 50103344
Agitation 40.27 9.89 245 391647 53139 50160093
Dysgeusia 40.09 9.89 160 391732 38756 50174476
Posterior reversible encephalopathy syndrome 40.00 9.89 34 391858 14894 50198338
Ascites 39.82 9.89 143 391749 35718 50177514
Depression 39.45 9.89 977 390915 164446 50048786
Cerebral haemorrhage 39.38 9.89 95 391797 26957 50186275
Palpitations 39.19 9.89 506 391386 94000 50119232
Vertigo 38.51 9.89 239 391653 51593 50161639
Memory impairment 38.27 9.89 411 391481 78949 50134283
Loss of personal independence in daily activities 38.12 9.89 758 391134 69292 50143940
Tuberculosis 38.05 9.89 167 391725 9916 50203316
Peripheral swelling 37.68 9.89 1953 389939 203983 50009249
Chronic kidney disease 37.59 9.89 169 391723 39602 50173630
Blood calcium decreased 37.58 9.89 64 391828 20642 50192590
Metastases to liver 37.54 9.89 61 391831 20043 50193189
Sopor 37.42 9.89 60 391832 19819 50193413
Somnolence 37.05 9.89 915 390977 154070 50059162
Infective pulmonary exacerbation of cystic fibrosis 36.97 9.89 8 391884 7901 50205331
Device dislocation 36.94 9.89 69 391823 21477 50191755
Haemorrhage 36.87 9.89 252 391640 53189 50160043
Ejection fraction decreased 36.68 9.89 54 391838 18466 50194766
Rheumatoid nodule 36.57 9.89 195 391697 12540 50200692
Mental status changes 36.19 9.89 151 391741 36121 50177111
Flushing 36.08 9.89 338 391554 66677 50146555
Blood pressure decreased 35.97 9.89 269 391623 55640 50157592
Blood alkaline phosphatase increased 35.74 9.89 159 391733 37367 50175865
Drug ineffective for unapproved indication 35.74 9.89 69 391823 21212 50192020
Toxicity to various agents 35.45 9.89 1998 389894 210501 50002731
Ventricular septal defect 35.32 9.89 89 391803 3952 50209280
Cerebrovascular accident 34.94 9.89 519 391373 94161 50119071
Pre-eclampsia 34.87 9.89 139 391753 7905 50205327
Back pain 34.80 9.89 1372 390520 218658 49994574
Dysphagia 34.80 9.89 408 391484 77110 50136122
Pyrexia 34.47 9.89 2507 389385 377696 49835536
Wrong technique in product usage process 34.34 9.89 270 391622 55240 50157992
Altered state of consciousness 34.28 9.89 74 391818 21836 50191396
Disseminated intravascular coagulation 33.90 9.89 50 391842 17085 50196147
Blood bilirubin increased 33.46 9.89 131 391761 31907 50181325
Disorientation 33.40 9.89 151 391741 35333 50177899
Enthesopathy 33.38 9.89 127 391765 7066 50206166
Anaphylactic shock 33.29 9.89 66 391826 20089 50193143
Maternal exposure before pregnancy 33.04 9.89 107 391785 5490 50207742
Polyarthritis 32.78 9.89 135 391757 7792 50205440
Diabetes mellitus inadequate control 32.77 9.89 32 391860 13113 50200119
Inappropriate antidiuretic hormone secretion 32.76 9.89 32 391860 13111 50200121
Headache 32.63 9.89 3430 388462 503105 49710127
Extrapyramidal disorder 32.54 9.89 26 391866 11744 50201488
Sepsis 32.52 9.89 782 391110 132143 50081089
Gastrointestinal haemorrhage 32.49 9.89 387 391505 72934 50140298
Infection 32.40 9.89 1644 390248 171310 50041922
Pleural effusion 32.35 9.89 440 391452 81014 50132218
Alcohol abuse 32.22 9.89 55 391837 1846 50211386
Product dose omission issue 32.04 9.89 1133 390759 182705 50030527
Blood pressure diastolic decreased 31.85 9.89 231 391661 16550 50196682
Aspartate aminotransferase increased 31.82 9.89 419 391473 77579 50135653
Gamma-glutamyltransferase increased 31.66 9.89 120 391772 29503 50183729
Limb deformity 31.35 9.89 81 391811 3653 50209579
Localised infection 31.07 9.89 318 391574 25167 50188065
Joint destruction 30.90 9.89 83 391809 3833 50209399
Atrial fibrillation 30.59 9.89 579 391313 101166 50112066
Nodule 30.53 9.89 231 391661 16772 50196460
Joint stiffness 30.46 9.89 364 391528 29944 50183288
Metabolic acidosis 30.44 9.89 176 391716 38649 50174583
Small for dates baby 30.43 9.89 77 391815 3428 50209804
Premature rupture of membranes 30.22 9.89 91 391801 4489 50208743
Hypomagnesaemia 30.14 9.89 86 391806 23070 50190162
International normalised ratio increased 30.01 9.89 203 391689 42949 50170283
Drug withdrawal syndrome 29.89 9.89 97 391795 24984 50188248
Heart rate decreased 29.82 9.89 422 391470 36075 50177157
Pulmonary hypertension 29.81 9.89 145 391747 33272 50179960
Oedema peripheral 29.74 9.89 964 390928 156997 50056235
Injection site rash 29.74 9.89 221 391671 15956 50197276
Device difficult to use 29.72 9.89 20 391872 9866 50203366
Torsade de pointes 29.29 9.89 29 391863 11806 50201426
Off label use 29.28 9.89 3222 388670 471204 49742028
Premature delivery 29.20 9.89 296 391596 23367 50189865
Respiratory distress 29.15 9.89 129 391763 30360 50182872
Muscular weakness 29.09 9.89 539 391353 94474 50118758
Alanine aminotransferase increased 28.71 9.89 496 391396 87863 50125369
Melaena 28.60 9.89 109 391783 26755 50186477
Polyneuropathy 28.58 9.89 31 391861 12100 50201132
Weight increased 28.56 9.89 1871 390021 200020 50013212
Abdominal distension 28.52 9.89 395 391497 72508 50140724
Toxic skin eruption 28.50 9.89 27 391865 11224 50202008
Tenosynovitis stenosans 28.44 9.89 57 391835 2167 50211065
Dyskinesia 28.41 9.89 115 391777 27746 50185486
Eosinophilia 28.36 9.89 64 391828 18588 50194644
Tenderness 28.32 9.89 243 391649 18322 50194910
Ischaemic stroke 28.30 9.89 50 391842 15898 50197334
Abdominal pain 28.27 9.89 1518 390374 234710 49978522
Cytokine release syndrome 27.99 9.89 16 391876 8618 50204614
Pulmonary fibrosis 27.95 9.89 301 391591 24136 50189096
Disability 27.88 9.89 182 391710 12593 50200639
Neuroleptic malignant syndrome 27.86 9.89 27 391865 11103 50202129
Parkinsonism 27.82 9.89 17 391875 8830 50204402
C-reactive protein increased 27.55 9.89 692 391200 65782 50147450
Metastases to central nervous system 27.51 9.89 28 391864 11254 50201978
Atrioventricular block complete 27.25 9.89 11 391881 7244 50205988
Blood creatinine increased 27.23 9.89 420 391472 75740 50137492
Hypothermia 26.90 9.89 32 391860 11984 50201248
Restlessness 26.89 9.89 102 391790 25071 50188161
Bronchospasm 26.88 9.89 46 391846 14808 50198424
Injection site bruising 26.85 9.89 417 391475 36351 50176881
Transplant rejection 26.85 9.89 21 391871 9588 50203644
Smear cervix abnormal 26.77 9.89 63 391829 2678 50210554
Delirium 26.39 9.89 180 391712 38012 50175220
Neurotoxicity 26.35 9.89 46 391846 14694 50198538
Synovial cyst 26.21 9.89 129 391763 8037 50205195
Thrombotic microangiopathy 26.14 9.89 18 391874 8773 50204459
COVID-19 26.13 9.89 233 391659 46429 50166803
Obstructive airways disorder 26.07 9.89 51 391841 15601 50197631
Inflammation 25.86 9.89 600 391292 56312 50156920
Latent tuberculosis 25.76 9.89 55 391837 2188 50211044
Jaundice 25.76 9.89 111 391781 26318 50186914
Acute generalised exanthematous pustulosis 25.66 9.89 19 391873 8919 50204313
Blood pressure diastolic increased 25.64 9.89 120 391772 7323 50205909
Arrhythmia 25.54 9.89 151 391741 32981 50180251
Blood alcohol increased 25.46 9.89 27 391865 565 50212667
Developmental hip dysplasia 25.46 9.89 40 391852 1251 50211981
Agranulocytosis 25.42 9.89 83 391809 21338 50191894
Bradyphrenia 25.37 9.89 8 391884 6144 50207088
Acute myeloid leukaemia 25.21 9.89 49 391843 15025 50198207
Femur fracture 25.15 9.89 419 391473 37045 50176187
Second primary malignancy 25.14 9.89 11 391881 6903 50206329
Intentional self-injury 25.11 9.89 93 391799 23019 50190213
Haematotoxicity 25.07 9.89 15 391877 7880 50205352
Joint range of motion decreased 25.01 9.89 236 391656 18276 50194956
Schizophrenia 25.01 9.89 13 391879 7384 50205848
Hypervolaemia 24.91 9.89 107 391785 25392 50187840
Dysmorphism 24.73 9.89 53 391839 2114 50211118
Febrile bone marrow aplasia 24.65 9.89 9 391883 6302 50206930
Tenosynovitis 24.60 9.89 153 391739 10412 50202820
Laryngitis 24.47 9.89 157 391735 10799 50202433
Acute respiratory failure 24.47 9.89 127 391765 28655 50184577
Musculoskeletal pain 24.43 9.89 732 391160 71445 50141787
Pancreatitis 24.21 9.89 212 391680 42402 50170830
Psychotic disorder 24.20 9.89 87 391805 21725 50191507
Unevaluable event 24.09 9.89 234 391658 45832 50167400
Wheelchair user 24.08 9.89 89 391803 4883 50208349
Graft versus host disease 23.73 9.89 9 391883 6157 50207075
Stress cardiomyopathy 23.65 9.89 16 391876 7871 50205361
Seizure 23.48 9.89 714 391178 117160 50096072
Skin papilloma 23.32 9.89 79 391813 4150 50209082
Pancreatitis acute 23.22 9.89 100 391792 23712 50189520
Arthritis infective 23.16 9.89 95 391797 5474 50207758
Immune reconstitution inflammatory syndrome 23.06 9.89 7 391885 5509 50207723
Rash maculo-papular 22.96 9.89 117 391775 26524 50186708
Complication of device insertion 22.95 9.89 9 391883 6032 50207200
Product administration error 22.91 9.89 77 391815 19622 50193610
Hemiparesis 22.89 9.89 79 391813 19969 50193263
Tardive dyskinesia 22.87 9.89 14 391878 7265 50205967
Acute hepatic failure 22.86 9.89 55 391837 15622 50197610
Drug tolerance decreased 22.81 9.89 135 391757 9025 50204207
Complication associated with device 22.51 9.89 50 391842 14605 50198627
Malaise 22.51 9.89 2265 389627 333267 49879965
Plasma cell myeloma 22.46 9.89 146 391746 31176 50182056
Placental disorder 22.45 9.89 40 391852 1390 50211842
Dystonia 22.44 9.89 36 391856 11890 50201342
Neck mass 22.38 9.89 67 391825 3294 50209938
Disease recurrence 22.34 9.89 80 391812 20001 50193231
Tumour lysis syndrome 22.32 9.89 15 391877 7406 50205826
Cytopenia 22.30 9.89 21 391871 8754 50204478
Postmortem blood drug level abnormal 22.29 9.89 20 391872 338 50212894
Crying 22.28 9.89 82 391810 20334 50192898
Irritability 22.20 9.89 129 391763 28297 50184935
Synovial fluid analysis 22.18 9.89 43 391849 1595 50211637
Malignant melanoma 22.06 9.89 144 391748 9964 50203268
Blood creatine phosphokinase increased 22.05 9.89 117 391775 26250 50186982
Stevens-Johnson syndrome 22.04 9.89 90 391802 21662 50191570
Liver injury 21.97 9.89 291 391601 24515 50188717
Metastases to lung 21.96 9.89 32 391860 10988 50202244
Glycosylated haemoglobin increased 21.92 9.89 30 391862 10576 50202656
Dementia 21.87 9.89 58 391834 15939 50197293
Drug dependence 21.80 9.89 79 391813 19680 50193552
Blood potassium decreased 21.79 9.89 182 391710 36763 50176469
Dysarthria 21.73 9.89 185 391707 37218 50176014
Paralysis 21.70 9.89 21 391871 8643 50204589
Genital haemorrhage 21.57 9.89 12 391880 6562 50206670
Urinary retention 21.46 9.89 117 391775 26073 50187159
Erythema multiforme 21.46 9.89 23 391869 9027 50204205
Mania 21.45 9.89 32 391860 10884 50202348
Device use error 21.45 9.89 7 391885 5259 50207973
Polyhydramnios 21.38 9.89 48 391844 1977 50211255
Wheezing 21.23 9.89 345 391547 61702 50151530
Atrial septal defect 20.95 9.89 101 391791 6240 50206992
Skin ulcer 20.85 9.89 387 391505 34931 50178301
Rotator cuff repair 20.78 9.89 43 391849 1673 50211559
Nightmare 20.75 9.89 60 391832 16026 50197206
Acute graft versus host disease 20.68 9.89 3 391889 3955 50209277
Cardiac failure acute 20.66 9.89 20 391872 8230 50205002
Anhedonia 20.65 9.89 26 391866 9498 50203734
Loose body in joint 20.64 9.89 35 391857 1168 50212064
Uterine perforation 20.63 9.89 12 391880 6403 50206829
Pemphigoid 20.54 9.89 10 391882 5897 50207335
Coagulopathy 20.29 9.89 71 391821 17873 50195359
Panic attack 20.25 9.89 79 391813 19263 50193969
Skin exfoliation 20.09 9.89 165 391727 33447 50179785
Haemorrhage intracranial 20.02 9.89 41 391851 12333 50200899
Shock haemorrhagic 20.02 9.89 21 391871 8323 50204909
Brain oedema 20.00 9.89 41 391851 12329 50200903
Haematoma 20.00 9.89 146 391746 30364 50182868
Hyperlipidaemia 19.91 9.89 69 391823 17421 50195811
Proteinuria 19.91 9.89 64 391828 16533 50196699
Infusion site pain 19.90 9.89 41 391851 12305 50200927
Unresponsive to stimuli 19.81 9.89 147 391745 30462 50182770
Infusion site erythema 19.80 9.89 23 391869 8704 50204528
Fear 19.70 9.89 53 391839 14496 50198736
Lymphocyte count decreased 19.70 9.89 121 391771 26186 50187046
Oedema 19.69 9.89 404 391488 69777 50143455
Device related infection 19.66 9.89 88 391804 20647 50192585
Abdominal pain upper 19.55 9.89 1021 390871 158288 50054944
Confusional state 19.48 9.89 1210 390682 184718 50028514
Pulmonary tuberculosis 19.46 9.89 75 391817 4198 50209034
Spinal stenosis 19.45 9.89 175 391717 13375 50199857
Product adhesion issue 19.43 9.89 5 391887 4387 50208845
Diabetes mellitus 19.41 9.89 265 391627 48768 50164464
Shock 19.36 9.89 88 391804 20562 50192670
Sleep apnoea syndrome 19.35 9.89 107 391785 23761 50189471
Cholecystitis chronic 19.34 9.89 28 391864 9641 50203591
Body temperature decreased 19.24 9.89 203 391689 16192 50197040
Withdrawal syndrome 18.96 9.89 71 391821 17519 50195713
Accidental exposure to product 18.90 9.89 103 391789 22954 50190278
Clostridium difficile colitis 18.88 9.89 72 391820 17670 50195562
Angina pectoris 18.81 9.89 122 391770 26066 50187166
Drug level increased 18.73 9.89 81 391811 19187 50194045
Bone marrow failure 18.69 9.89 131 391761 27493 50185739
Postoperative wound infection 18.66 9.89 121 391771 8354 50204878
Myoclonus 18.64 9.89 54 391838 14416 50198816
Paradoxical drug reaction 18.52 9.89 3 391889 3644 50209588
Multiple allergies 18.46 9.89 23 391869 8440 50204792
Haemoptysis 18.44 9.89 119 391773 25454 50187778
Subdural haematoma 18.43 9.89 46 391846 12901 50200331
Tachypnoea 18.34 9.89 55 391837 14522 50198710
Acute chest syndrome 18.32 9.89 24 391868 633 50212599
Haemophagocytic lymphohistiocytosis 18.27 9.89 24 391868 8609 50204623
Body height below normal 18.17 9.89 44 391848 1905 50211327
Oropharyngeal pain 18.11 9.89 756 391136 77045 50136187
Cardiomyopathy 18.08 9.89 61 391831 15525 50197707
Dry skin 17.99 9.89 231 391661 42960 50170272
Face oedema 17.96 9.89 74 391818 17765 50195467
Complication of device removal 17.93 9.89 5 391887 4159 50209073
Generalised oedema 17.87 9.89 51 391841 13680 50199552
Accidental overdose 17.86 9.89 84 391808 19449 50193783
Myopathy 17.76 9.89 27 391865 9112 50204120
Maternal exposure timing unspecified 17.70 9.89 65 391827 3555 50209677
Foetal anticonvulsant syndrome 17.69 9.89 22 391870 550 50212682
Respiratory depression 17.62 9.89 42 391850 11968 50201264
Labelled drug-drug interaction medication error 17.57 9.89 34 391858 10443 50202789
Joint dislocation 17.55 9.89 159 391733 12174 50201058
Hypophagia 17.55 9.89 134 391758 27594 50185638
Foetal death 17.53 9.89 116 391776 8064 50205168
Haemorrhage in pregnancy 17.48 9.89 40 391852 1669 50211563
Congenital arterial malformation 17.47 9.89 17 391875 320 50212912
Lip swelling 17.38 9.89 116 391776 24620 50188612
Akathisia 17.29 9.89 23 391869 8206 50205026
Red blood cell sedimentation rate 17.21 9.89 64 391828 3522 50209710
Hypophosphataemia 17.19 9.89 24 391868 8390 50204842
Rash erythematous 16.99 9.89 180 391712 34672 50178560
Aphasia 16.97 9.89 140 391752 28354 50184878
Injection site warmth 16.89 9.89 173 391719 13693 50199539
Gastroenteritis viral 16.89 9.89 221 391671 18565 50194667
Visual impairment 16.87 9.89 401 391491 67874 50145358
Coronary artery disease 16.83 9.89 148 391744 29578 50183654
Crohn's disease 16.81 9.89 77 391815 4656 50208576
Clear cell renal cell carcinoma 16.80 9.89 32 391860 1171 50212061
Pulmonary oedema 16.78 9.89 272 391620 48666 50164566
Hypomania 16.65 9.89 7 391885 4498 50208734
Hyperprolactinaemia 16.57 9.89 3 391889 3362 50209870
Temperature regulation disorder 16.56 9.89 6 391886 4221 50209011
Aspergillus infection 16.55 9.89 17 391875 6804 50206428
Toxic epidermal necrolysis 16.54 9.89 95 391797 20897 50192335
Synovial disorder 16.54 9.89 27 391865 873 50212359
Therapeutic response decreased 16.52 9.89 481 391411 46750 50166482
Salivary hypersecretion 16.48 9.89 16 391876 6575 50206657
Pathogen resistance 16.45 9.89 12 391880 5677 50207555
Nervousness 16.40 9.89 136 391756 27515 50185717
Muscle rigidity 16.39 9.89 32 391860 9797 50203435
Joint noise 16.37 9.89 63 391829 3524 50209708
Cerebral infarction 16.37 9.89 99 391793 21505 50191727
Breast feeding 16.34 9.89 26 391866 822 50212410
Pseudomonas infection 16.34 9.89 30 391862 9400 50203832
Stillbirth 16.32 9.89 90 391802 5862 50207370
Dactylitis 16.28 9.89 41 391851 1820 50211412
Hypertransaminasaemia 16.19 9.89 4 391888 3607 50209625
Infusion site swelling 16.18 9.89 19 391873 7157 50206075
Ketoacidosis 16.18 9.89 5 391887 3890 50209342
Bronchopulmonary aspergillosis 16.18 9.89 21 391871 7571 50205661
Gestational hypertension 16.09 9.89 45 391847 2128 50211104
Colitis 16.07 9.89 206 391686 38323 50174909
Antinuclear antibody positive 15.98 9.89 93 391799 6179 50207053
Right ventricular failure 15.95 9.89 66 391826 15827 50197405
Neonatal respiratory distress syndrome 15.90 9.89 51 391841 2603 50210629
Vascular device infection 15.90 9.89 7 391885 4377 50208855
Fear of injection 15.88 9.89 91 391801 6012 50207220
Status epilepticus 15.87 9.89 52 391840 13354 50199878
Scleritis 15.83 9.89 58 391834 3169 50210063
Lethargy 15.57 9.89 279 391613 49153 50164079
Alcoholism 15.56 9.89 37 391855 1583 50211649
Joint injury 15.48 9.89 246 391646 21543 50191689
Suicidal ideation 15.48 9.89 319 391573 55066 50158166
Ulcer 15.48 9.89 231 391661 19969 50193263
Talipes 15.47 9.89 34 391858 1380 50211852
Abnormal behaviour 15.47 9.89 89 391803 19569 50193663
Paraesthesia 15.44 9.89 767 391125 119476 50093756
Product prescribing error 15.39 9.89 97 391795 20864 50192368
Hallucination, auditory 15.36 9.89 38 391854 10690 50202542
Cushingoid 15.32 9.89 96 391796 6549 50206683
Acute myocardial infarction 15.17 9.89 149 391743 29124 50184108
Swollen tongue 15.15 9.89 145 391747 28485 50184747
Device breakage 15.14 9.89 32 391860 9515 50203717
Fall 15.08 9.89 2320 389572 332612 49880620
Colitis microscopic 14.99 9.89 17 391875 6503 50206729
Product substitution issue 14.98 9.89 57 391835 14000 50199232
Hot flush 14.97 9.89 246 391646 43923 50169309
Myelosuppression 14.94 9.89 54 391838 13463 50199769
Affective disorder 14.89 9.89 11 391881 5170 50208062
Visual acuity reduced 14.88 9.89 93 391799 20046 50193186
Lupus-like syndrome 14.88 9.89 125 391767 9366 50203866
Skin cancer 14.88 9.89 124 391768 9270 50203962
Stomatitis 14.82 9.89 942 390950 100402 50112830
Dysuria 14.81 9.89 145 391747 28359 50184873
Fracture delayed union 14.81 9.89 45 391847 2231 50211001
Dislocation of vertebra 14.73 9.89 55 391837 3032 50210200
Cardiac disorder 14.69 9.89 239 391653 42740 50170492
Anuria 14.46 9.89 42 391850 11202 50202030
Respiration abnormal 14.45 9.89 11 391881 5091 50208141
Urinary incontinence 14.45 9.89 144 391748 28064 50185168
Renal injury 14.39 9.89 28 391864 8583 50204649
Oral herpes 14.36 9.89 233 391659 20492 50192740
Leukocytosis 14.35 9.89 109 391783 22470 50190762
Pharyngitis streptococcal 14.34 9.89 117 391775 8691 50204541
Muscle twitching 14.32 9.89 66 391826 15365 50197867
Human antichimeric antibody positive 14.30 9.89 34 391858 1455 50211777
Purpura 14.27 9.89 35 391857 9876 50203356
Klebsiella infection 14.22 9.89 21 391871 7173 50206059
Tumour marker increased 14.13 9.89 6 391886 3834 50209398
Blood glucose decreased 14.03 9.89 83 391809 18128 50195104
Syndactyly 13.99 9.89 15 391877 318 50212914
Product complaint 13.90 9.89 44 391848 11422 50201810
Ventricular fibrillation 13.90 9.89 39 391853 10520 50202712
Fracture 13.89 9.89 195 391697 16638 50196594
Therapy change 13.88 9.89 12 391880 5213 50208019
Polyuria 13.87 9.89 21 391871 7100 50206132
Hereditary angioedema 13.86 9.89 13 391879 5429 50207803
Chills 13.76 9.89 610 391282 96077 50117155
Speech disorder developmental 13.71 9.89 20 391872 585 50212647
Herpes zoster 13.68 9.89 675 391217 70111 50143121
Pain in extremity 13.64 9.89 2357 389535 270508 49942724
Injection site haematoma 13.63 9.89 87 391805 5973 50207259
Hallucination, visual 13.63 9.89 74 391818 16508 50196724
Exomphalos 13.59 9.89 19 391873 534 50212698
Mood altered 13.48 9.89 52 391840 12721 50200511
Antibody test positive 13.48 9.89 44 391848 2267 50210965
Presyncope 13.47 9.89 121 391771 24077 50189155
Renal disorder 13.43 9.89 142 391750 27363 50185869
Dermatitis exfoliative 13.43 9.89 12 391880 5130 50208102
Transplant dysfunction 13.39 9.89 10 391882 4674 50208558
Lymphoedema 13.30 9.89 32 391860 9090 50204142
Cholestasis of pregnancy 13.30 9.89 28 391864 1103 50212129
Epstein-Barr virus infection 13.28 9.89 21 391871 6976 50206256
Hyperthyroidism 13.22 9.89 49 391843 12126 50201106
Mouth ulceration 13.21 9.89 297 391595 27727 50185505
Infusion site pruritus 13.19 9.89 7 391885 3930 50209302
Immunodeficiency 13.15 9.89 174 391718 14654 50198578
Blood loss anaemia 13.14 9.89 27 391865 8112 50205120
Sinus bradycardia 13.07 9.89 55 391837 13128 50200104
Tubulointerstitial nephritis 12.99 9.89 67 391825 15144 50198088
Hepatic cytolysis 12.98 9.89 27 391865 8076 50205156
Congenital umbilical hernia 12.98 9.89 14 391878 299 50212933
Trigeminal neuralgia 12.94 9.89 4 391888 3111 50210121
Blood iron increased 12.88 9.89 31 391861 1337 50211895
Hypertelorism 12.84 9.89 16 391876 401 50212831
Autism spectrum disorder 12.79 9.89 21 391871 682 50212550
Patent ductus arteriosus 12.73 9.89 61 391831 3759 50209473
Atrioventricular block 12.72 9.89 19 391873 6459 50206773
Acute pulmonary oedema 12.70 9.89 23 391869 7244 50205988
Mental disorder 12.67 9.89 109 391783 21882 50191350
Joint lock 12.67 9.89 40 391852 2025 50211207
Rectal haemorrhage 12.66 9.89 216 391676 38342 50174890
Amylase increased 12.65 9.89 14 391878 5416 50207816
Pregnancy with contraceptive device 12.60 9.89 8 391884 4071 50209161
Poor venous access 12.59 9.89 129 391763 10211 50203021
Foetal distress syndrome 12.58 9.89 29 391863 1216 50212016
Pericardial effusion 12.54 9.89 132 391760 25457 50187775
Pneumonia viral 12.51 9.89 21 391871 6813 50206419
Bundle branch block left 12.50 9.89 18 391874 6212 50207020
Bone lesion 12.42 9.89 13 391879 5157 50208075
Device issue 12.41 9.89 97 391795 19875 50193357
Induced labour 12.38 9.89 24 391868 890 50212342
Loss of consciousness 12.38 9.89 671 391221 103682 50109550
Cervical incompetence 12.36 9.89 19 391873 583 50212649
Sexual dysfunction 12.35 9.89 5 391887 3287 50209945
Peripheral sensory neuropathy 12.31 9.89 20 391872 6571 50206661
Food allergy 12.30 9.89 28 391864 8109 50205123
Taste disorder 12.30 9.89 29 391863 8295 50204937
Immunosuppression 12.29 9.89 99 391793 7327 50205905
Squamous cell carcinoma 12.17 9.89 102 391790 7637 50205595
Arthritis bacterial 12.17 9.89 80 391812 5549 50207683
Catheter site pain 12.15 9.89 7 391885 3755 50209477
Eosinophil count increased 12.08 9.89 32 391860 8798 50204434
Hypocalcaemia 12.08 9.89 141 391751 26675 50186557
Injection site irritation 12.08 9.89 66 391826 4284 50208948
Occult blood 12.07 9.89 28 391864 1179 50212053
Acute coronary syndrome 12.06 9.89 35 391857 9339 50203893
Catatonia 12.00 9.89 7 391885 3729 50209503
Bundle branch block right 11.94 9.89 11 391881 4634 50208598
Catheter site erythema 11.93 9.89 8 391884 3954 50209278
Abortion missed 11.87 9.89 33 391859 1555 50211677
Malignant mediastinal neoplasm 11.86 9.89 18 391874 546 50212686
Body temperature increased 11.83 9.89 171 391721 31170 50182062
Bradykinesia 11.82 9.89 8 391884 3935 50209297
Lymphatic fistula 11.80 9.89 21 391871 729 50212503
Systemic inflammatory response syndrome 11.79 9.89 13 391879 5036 50208196
Psychomotor hyperactivity 11.77 9.89 35 391857 9266 50203966
Joint warmth 11.67 9.89 30 391862 1349 50211883
Product preparation error 11.66 9.89 10 391882 4362 50208870
Coronary arterial stent insertion 11.65 9.89 3 391889 2631 50210601
Tendonitis 11.64 9.89 188 391704 16517 50196715
Human anti-human antibody test 11.61 9.89 15 391877 390 50212842
Hypothyroidism 11.59 9.89 190 391702 33935 50179297
Femoral hernia incarcerated 11.58 9.89 21 391871 740 50212492
Rhinitis allergic 11.53 9.89 24 391868 7176 50206056
Eating disorder 11.47 9.89 71 391821 15338 50197894
Product physical issue 11.44 9.89 10 391882 4322 50208910
Hallucinations, mixed 11.42 9.89 9 391883 4094 50209138
Head injury 11.33 9.89 125 391767 23895 50189337
Abortion incomplete 11.32 9.89 5 391887 3121 50210111
Full blood count abnormal 11.32 9.89 121 391771 23267 50189965
Polydipsia 11.31 9.89 5 391887 3119 50210113
Serum ferritin increased 11.29 9.89 74 391818 5128 50208104
Bone disorder 11.25 9.89 206 391686 18546 50194686
Embedded device 11.16 9.89 4 391888 2833 50210399
Tendon disorder 11.12 9.89 75 391817 5247 50207985
Wound infection pseudomonas 11.09 9.89 28 391864 1245 50211987
Metabolic encephalopathy 11.08 9.89 14 391878 5107 50208125
Lung transplant 11.08 9.89 4 391888 2821 50210411
Threatened labour 11.07 9.89 21 391871 766 50212466
Ageusia 11.07 9.89 49 391843 11534 50201698
Retrognathia 11.07 9.89 15 391877 409 50212823
Breast cancer metastatic 11.06 9.89 42 391850 10322 50202910
Ankylosing spondylitis 11.04 9.89 94 391798 7071 50206161
Depressed mood 11.04 9.89 191 391701 33832 50179400
Intracranial pressure increased 11.01 9.89 10 391882 4242 50208990
Toxic encephalopathy 11.00 9.89 16 391876 5499 50207733
Hyperuricaemia 10.98 9.89 12 391880 4668 50208564
Abortion threatened 10.95 9.89 17 391875 526 50212706
Multiple-drug resistance 10.95 9.89 6 391886 3308 50209924
Surgery 10.94 9.89 309 391583 29896 50183336
Restless legs syndrome 10.94 9.89 75 391817 15822 50197410
Intellectual disability 10.94 9.89 21 391871 773 50212459
Anterior chamber cleavage syndrome 10.91 9.89 10 391882 174 50213058
Maternal exposure during breast feeding 10.87 9.89 52 391840 3202 50210030
Ingrown hair 10.84 9.89 16 391876 473 50212759
Oxygen consumption increased 10.84 9.89 7 391885 3529 50209703
Anger 10.80 9.89 48 391844 11285 50201947
Tongue disorder 10.76 9.89 114 391778 9102 50204130
Endodontic procedure 10.76 9.89 46 391846 2700 50210532
Ventricular tachycardia 10.71 9.89 75 391817 15746 50197486
Drug-induced liver injury 10.71 9.89 153 391739 27942 50185290
Epistaxis 10.70 9.89 396 391496 63558 50149674
Myofascial pain syndrome 10.69 9.89 38 391854 2045 50211187
Troponin increased 10.67 9.89 30 391862 8088 50205144
Placenta praevia haemorrhage 10.64 9.89 8 391884 104 50213128
Chemical submission 10.64 9.89 10 391882 180 50213052
Learning disorder 10.63 9.89 18 391874 600 50212632
Blood urea increased 10.63 9.89 124 391768 23461 50189771
Crystal nephropathy 10.56 9.89 21 391871 794 50212438
Wound infection 10.54 9.89 142 391750 12006 50201226
Catheter management 10.54 9.89 4 391888 2735 50210497
Embolism 10.52 9.89 24 391868 6944 50206288
Forceps delivery 10.50 9.89 10 391882 183 50213049
Pneumonia 10.48 9.89 2687 389205 375714 49837518
Bone density abnormal 10.42 9.89 49 391843 2996 50210236
Knee operation 10.38 9.89 69 391823 4804 50208428
Inflammatory marker increased 10.37 9.89 77 391815 5557 50207675
Atrial flutter 10.37 9.89 34 391858 8729 50204503
Lung adenocarcinoma 10.34 9.89 61 391831 4073 50209159
Oliguria 10.34 9.89 31 391861 8185 50205047
Hyperlactacidaemia 10.33 9.89 3 391889 2430 50210802
Septic shock 10.26 9.89 351 391541 56824 50156408
Post procedural haemorrhage 10.21 9.89 26 391866 7244 50205988
Protein C increased 10.21 9.89 8 391884 111 50213121
Rheumatoid lung 10.21 9.89 42 391850 2423 50210809
Lipase increased 10.20 9.89 33 391859 8508 50204724
Hypernatraemia 10.18 9.89 21 391871 6300 50206932
Foot fracture 10.13 9.89 215 391677 19876 50193356
Hepatitis cholestatic 10.13 9.89 20 391872 6097 50207135
Middle insomnia 10.08 9.89 41 391851 9880 50203352
Victim of sexual abuse 10.08 9.89 16 391876 505 50212727
Cytomegalovirus viraemia 10.06 9.89 13 391879 4696 50208536
Hepatitis acute 10.04 9.89 30 391862 7931 50205301
Vacuum extractor delivery 10.04 9.89 9 391883 152 50213080
Ankyloglossia congenital 10.03 9.89 10 391882 194 50213038
Plasma cell myeloma recurrent 10.03 9.89 4 391888 2654 50210578
Persecutory delusion 10.03 9.89 3 391889 2384 50210848
Nail injury 10.03 9.89 15 391877 449 50212783
Placental insufficiency 9.96 9.89 27 391865 1254 50211978
Electrolyte imbalance 9.93 9.89 85 391807 17084 50196148
Delusion 9.93 9.89 45 391847 10524 50202708
Multiple sclerosis 9.92 9.89 106 391786 20387 50192845

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 1073.43 9.95 1675 153047 78208 29341597
Completed suicide 866.19 9.95 1630 153092 88616 29331189
Toxicity to various agents 519.56 9.95 2036 152686 171625 29248180
Rheumatoid arthritis 454.44 9.95 691 154031 31461 29388344
Foetal exposure during pregnancy 271.37 9.95 568 154154 33299 29386506
Alcohol interaction 216.08 9.95 149 154573 2554 29417251
Alcohol abuse 211.57 9.95 178 154544 4155 29415650
Cardio-respiratory arrest 184.88 9.95 634 154088 49967 29369838
Arthralgia 145.41 9.95 1236 153486 138381 29281424
Psoriatic arthropathy 132.62 9.95 259 154463 14432 29405373
Suspected suicide 127.87 9.95 130 154592 3890 29415915
Dysmorphism 122.79 9.95 111 154611 2860 29416945
Alcohol poisoning 121.02 9.95 112 154610 2977 29416828
Intentional overdose 116.42 9.95 454 154268 38074 29381731
Sickle cell anaemia with crisis 97.25 9.95 92 154630 2516 29417289
Premature baby 90.74 9.95 246 154476 17034 29402771
Acute kidney injury 89.46 9.95 922 153800 264345 29155460
Exposure during pregnancy 86.11 9.95 158 154564 8396 29411409
Enthesopathy 77.81 9.95 97 154625 3646 29416159
Joint swelling 75.99 9.95 482 154240 49148 29370657
Speech disorder developmental 72.50 9.95 68 154654 1839 29417966
Drug reaction with eosinophilia and systemic symptoms 72.16 9.95 28 154694 27964 29391841
Febrile neutropenia 70.77 9.95 324 154398 111916 29307889
Psoriasis 68.59 9.95 342 154380 31885 29387920
Product use in unapproved indication 68.00 9.95 230 154492 86645 29333160
Intentional product misuse 67.63 9.95 359 154363 34302 29385503
Substance abuse 66.60 9.95 124 154598 6663 29413142
Neonatal respiratory distress syndrome 65.62 9.95 90 154632 3720 29416085
Alcohol use 64.84 9.95 81 154641 3051 29416754
Tenosynovitis 64.02 9.95 88 154634 3645 29416160
Atrial septal defect 61.64 9.95 120 154602 6669 29413136
Suicide attempt 60.32 9.95 344 154378 33766 29386039
Foetal anticonvulsant syndrome 59.27 9.95 49 154673 1115 29418690
Hypospadias 57.98 9.95 75 154647 2927 29416878
Off label use 57.70 9.95 1169 153553 299631 29120174
Drug resistance 56.43 9.95 21 154701 21519 29398286
Blood pressure fluctuation 55.71 9.95 229 154493 19665 29400140
Autism spectrum disorder 52.75 9.95 59 154663 1973 29417832
Maternal drugs affecting foetus 52.59 9.95 82 154640 3811 29415994
Palmar-plantar erythrodysaesthesia syndrome 51.09 9.95 8 154714 14751 29405054
Hepatic function abnormal 50.96 9.95 79 154643 39180 29380625
Maternal exposure during pregnancy 50.43 9.95 83 154639 4040 29415765
Overdose 49.74 9.95 637 154085 79182 29340623
Musculoskeletal stiffness 49.04 9.95 350 154372 37108 29382697
Synovitis 47.45 9.95 145 154577 10745 29409060
Constipation 47.41 9.95 376 154346 113784 29306021
Pyrexia 46.78 9.95 1147 153575 286475 29133330
Blood alcohol increased 46.36 9.95 35 154687 695 29419110
Low birth weight baby 46.24 9.95 105 154617 6503 29413302
Disease progression 46.11 9.95 246 154476 81670 29338135
Renal failure 45.91 9.95 398 154324 118201 29301604
Learning disorder 45.85 9.95 40 154682 982 29418823
Small for dates baby 45.06 9.95 73 154649 3506 29416299
Cryptorchism 44.71 9.95 53 154669 1889 29417916
Hypoglycaemia neonatal 44.66 9.95 50 154672 1674 29418131
Angioedema 43.58 9.95 62 154660 31853 29387952
C-reactive protein abnormal 42.60 9.95 101 154621 6435 29413370
Cardiac failure 42.49 9.95 242 154480 79045 29340760
Tongue disorder 42.15 9.95 82 154640 4554 29415251
Drug interaction 42.09 9.95 753 153969 196632 29223173
Exposure to toxic agent 40.15 9.95 58 154664 2517 29417288
Maternal exposure during breast feeding 40.05 9.95 44 154678 1442 29418363
Cytomegalovirus infection 39.32 9.95 38 154684 23177 29396628
Ventricular septal defect 39.13 9.95 68 154654 3461 29416344
Syndactyly 38.17 9.95 32 154690 743 29419062
Nasopharyngitis 37.51 9.95 477 154245 59188 29360617
Urticaria 36.71 9.95 154 154568 54506 29365299
Alcohol withdrawal syndrome 35.87 9.95 40 154682 1333 29418472
Developmental delay 35.36 9.95 54 154668 2464 29417341
Foot deformity 35.28 9.95 70 154652 3945 29415860
Arthritis 34.64 9.95 237 154485 24782 29395023
Rheumatoid nodule 33.38 9.95 48 154674 2074 29417731
Renal impairment 32.77 9.95 270 154452 81063 29338742
Bradycardia 32.17 9.95 206 154516 65423 29354382
Joint laxity 32.05 9.95 22 154700 374 29419431
Talipes 31.87 9.95 43 154679 1749 29418056
Exposure via breast milk 31.86 9.95 42 154680 1670 29418135
Behaviour disorder 31.72 9.95 63 154659 3553 29416252
Congenital hand malformation 30.72 9.95 25 154697 556 29419249
Basal cell carcinoma 29.53 9.95 170 154552 16740 29403065
Asphyxia 29.24 9.95 77 154645 5238 29414567
Hypermobility syndrome 29.24 9.95 20 154702 338 29419467
Osteoarthritis 29.05 9.95 178 154544 17925 29401880
Alanine aminotransferase abnormal 28.98 9.95 54 154668 2903 29416902
Pulmonary fibrosis 28.76 9.95 159 154563 15423 29404382
Multiple organ dysfunction syndrome 28.49 9.95 203 154519 62913 29356892
Jaundice neonatal 28.46 9.95 34 154688 1222 29418583
Pain 28.38 9.95 1131 153591 170301 29249504
Drug dependence 28.01 9.95 197 154525 20784 29399021
Decreased appetite 28 9.95 564 154158 144778 29275027
Intellectual disability 27.80 9.95 32 154690 1105 29418700
Blood pressure systolic abnormal 27.10 9.95 44 154678 2117 29417688
Rash maculo-papular 26.88 9.95 54 154668 24235 29395570
Arthropathy 26.82 9.95 199 154523 21355 29398450
Hyperglycaemia 26.65 9.95 91 154631 34196 29385609
Lower respiratory tract infection 26.63 9.95 233 154489 26269 29393536
Neutropenia 26.30 9.95 508 154214 131203 29288602
Language disorder 26.10 9.95 41 154681 1918 29417887
Blood pressure systolic increased 26.01 9.95 164 154558 16681 29403124
Tendonitis 25.83 9.95 96 154626 7865 29411940
Foetal growth restriction 25.42 9.95 59 154663 3707 29416098
Plagiocephaly 25.29 9.95 21 154701 481 29419324
Large for dates baby 25.19 9.95 27 154695 860 29418945
Intentional product use issue 25.12 9.95 336 154386 42162 29377643
Malignant neoplasm progression 25.06 9.95 256 154466 73603 29346202
Toxic epidermal necrolysis 25.04 9.95 35 154687 18118 29401687
Pathogen resistance 24.72 9.95 6 154716 8110 29411695
Diarrhoea 24.19 9.95 1460 153262 331238 29088567
Hyperbilirubinaemia neonatal 23.61 9.95 24 154698 718 29419087
Hypoglycaemia 23.56 9.95 152 154570 48194 29371611
Joint effusion 23.41 9.95 61 154661 4123 29415682
Knee deformity 23.26 9.95 21 154701 540 29419265
Astigmatism 23.07 9.95 27 154695 949 29418856
Serum ferritin increased 23.04 9.95 73 154649 5515 29414290
Alcoholism 22.91 9.95 46 154676 2615 29417190
Polyarthritis 22.57 9.95 58 154664 3887 29415918
Attention deficit hyperactivity disorder 22.37 9.95 41 154681 2176 29417629
Hand deformity 22.27 9.95 40 154682 2090 29417715
Motor developmental delay 22.19 9.95 22 154700 638 29419167
Drug intolerance 21.77 9.95 365 154357 48014 29371791
Respiratory depression 21.71 9.95 133 154589 13390 29406415
Drug withdrawal syndrome neonatal 21.63 9.95 52 154670 3343 29416462
Neurotoxicity 21.36 9.95 27 154695 14586 29405219
Proteinuria 21.28 9.95 31 154691 15773 29404032
Caesarean section 21.25 9.95 37 154685 1886 29417919
Ex-drug abuser 21.22 9.95 12 154710 142 29419663
Selective eating disorder 21.05 9.95 34 154688 1629 29418176
Blood pressure increased 20.98 9.95 520 154202 73283 29346522
Dysgraphia 20.96 9.95 38 154684 2000 29417805
Hydrocele 20.83 9.95 37 154685 1916 29417889
Infective pulmonary exacerbation of cystic fibrosis 20.23 9.95 4 154718 6232 29413573
Diabetic ketoacidosis 20.23 9.95 33 154689 16040 29403765
Serotonin syndrome 20.18 9.95 38 154684 17474 29402331
Emphysema 19.86 9.95 94 154628 8577 29411228
Knee arthroplasty 19.64 9.95 71 154651 5738 29414067
Road traffic accident 19.55 9.95 144 154578 15417 29404388
Neuroleptic malignant syndrome 19.54 9.95 34 154688 16114 29403691
Skin cancer 19.54 9.95 92 154630 8376 29411429
Hypotonia neonatal 19.45 9.95 28 154694 1211 29418594
Strabismus 19.37 9.95 30 154692 1386 29418419
Delirium 19.12 9.95 124 154598 39273 29380532
Otitis media 19.08 9.95 42 154680 2547 29417258
Dyslexia 19.08 9.95 15 154707 317 29419488
Medical device implantation 19.03 9.95 19 154703 556 29419249
Cerebral haemorrhage 19.01 9.95 92 154630 31334 29388471
Infusion related reaction 18.98 9.95 329 154393 43557 29376248
Alcohol intolerance 18.82 9.95 16 154706 379 29419426
Blood creatinine increased 18.61 9.95 323 154399 84779 29335026
Dyspraxia 18.61 9.95 16 154706 385 29419420
Arthritis bacterial 18.52 9.95 58 154664 4355 29415450
Blood pressure diastolic abnormal 18.37 9.95 41 154681 2510 29417295
Wound 18.34 9.95 117 154605 11946 29407859
Agitation neonatal 18.27 9.95 25 154697 1031 29418774
Polydactyly 18.25 9.95 26 154696 1114 29418691
Sedation 18.16 9.95 40 154682 17365 29402440
Anaphylactic shock 18.11 9.95 26 154696 13310 29406495
Pruritus 18.09 9.95 469 154253 116380 29303425
Osteonecrosis of jaw 18.01 9.95 37 154685 16473 29403332
Status epilepticus 17.90 9.95 18 154704 10776 29409029
Respiratory failure 17.77 9.95 380 154342 96751 29323054
Dysgeusia 17.74 9.95 60 154662 22614 29397191
Venoocclusive liver disease 17.69 9.95 7 154715 6910 29412895
Poisoning deliberate 17.67 9.95 68 154654 5663 29414142
Foetal disorder 17.42 9.95 21 154701 762 29419043
Lacrimal disorder 17.29 9.95 14 154708 309 29419496
Psychomotor retardation 17.28 9.95 44 154678 2932 29416873
Body temperature decreased 17.20 9.95 105 154617 10559 29409246
Cleft lip 17.18 9.95 14 154708 312 29419493
Stevens-Johnson syndrome 17.14 9.95 38 154684 16459 29403346
Congenital bladder anomaly 17.14 9.95 13 154709 260 29419545
Drug ineffective for unapproved indication 17.14 9.95 30 154692 14184 29405621
Limb reduction defect 17.10 9.95 13 154709 261 29419544
Aggression 17.05 9.95 271 154451 35270 29384535
Product quality issue 17.02 9.95 36 154686 15859 29403946
Crohn's disease 16.97 9.95 44 154678 2965 29416840
Juvenile idiopathic arthritis 16.96 9.95 28 154694 1366 29418439
Weight decrease neonatal 16.92 9.95 14 154708 319 29419486
Patent ductus arteriosus 16.86 9.95 45 154677 3086 29416719
Blood pressure diastolic decreased 16.73 9.95 77 154645 6945 29412860
Renal aplasia 16.71 9.95 19 154703 647 29419158
Congenital foot malformation 16.61 9.95 15 154707 386 29419419
Congenital anomaly 16.60 9.95 27 154695 1301 29418504
Anal fistula 16.57 9.95 54 154668 4141 29415664
Neuropathy peripheral 16.37 9.95 267 154455 70760 29349045
Progressive multifocal leukoencephalopathy 16.30 9.95 13 154709 8706 29411099
Ankyloglossia congenital 16.17 9.95 13 154709 284 29419521
Aspergillus infection 16.04 9.95 19 154703 10562 29409243
Pancytopenia 15.97 9.95 558 154164 82610 29337195
Lactic acidosis 15.82 9.95 93 154629 30154 29389651
Loss of personal independence in daily activities 15.81 9.95 203 154519 25237 29394568
Vitamin D deficiency 15.76 9.95 64 154658 5465 29414340
Tuberculosis 15.75 9.95 77 154645 7119 29412686
Death 15.72 9.95 1559 153163 340525 29079280
Haemoglobin decreased 15.64 9.95 705 154017 107670 29312135
Haemangioma congenital 15.62 9.95 16 154706 483 29419322
Rhabdomyolysis 15.57 9.95 224 154498 60584 29359221
Dextrocardia 15.52 9.95 9 154713 112 29419693
Nausea 15.48 9.95 1303 153419 287952 29131853
Thrombocytopenia 15.28 9.95 564 154158 134259 29285546
Second primary malignancy 15.26 9.95 8 154714 6697 29413108
Bronchiolitis 15.25 9.95 40 154682 2715 29417090
Respiratory disorder neonatal 15.20 9.95 27 154695 1398 29418407
Diaphragmatic disorder 15.14 9.95 22 154700 960 29418845
Musculoskeletal pain 15.13 9.95 224 154498 28729 29391076
Agranulocytosis 15.12 9.95 55 154667 20285 29399520
Congenital diaphragmatic hernia 15.09 9.95 12 154710 258 29419547
Blood pressure diastolic increased 15.06 9.95 48 154674 3638 29416167
Rash 15.00 9.95 826 153896 188993 29230812
Multiple congenital abnormalities 14.97 9.95 16 154706 508 29419297
Arthrodesis 14.91 9.95 15 154707 443 29419362
Microcephaly 14.90 9.95 19 154703 731 29419074
Lipase increased 14.88 9.95 13 154709 8324 29411481
Post procedural infection 14.88 9.95 53 154669 4252 29415553
Nasal disorder 14.88 9.95 27 154695 1422 29418383
Pectus excavatum 14.85 9.95 11 154711 212 29419593
Cytokine release syndrome 14.66 9.95 29 154693 13090 29406715
Vascular insufficiency 14.44 9.95 13 154709 333 29419472
Scoliosis 14.41 9.95 35 154687 2265 29417540
Bradycardia neonatal 14.40 9.95 21 154701 919 29418886
Heart rate decreased 14.32 9.95 196 154526 24716 29395089
Oesophageal fibrosis 14.27 9.95 10 154712 176 29419629
Septic arthritis staphylococcal 14.24 9.95 15 154707 468 29419337
Dyspnoea 14.19 9.95 1495 153227 325237 29094568
Spina bifida 14.19 9.95 13 154709 341 29419464
Hypertelorism 14.12 9.95 16 154706 543 29419262
Foetal alcohol syndrome 14.02 9.95 9 154713 136 29419669
Hypocalcaemia 14.00 9.95 58 154664 20607 29399198
Hepatic fibrosis 13.89 9.95 43 154679 3209 29416596
Oedema 13.85 9.95 140 154582 40343 29379462
Maternal exposure timing unspecified 13.58 9.95 13 154709 361 29419444
C-reactive protein decreased 13.58 9.95 27 154695 1524 29418281
Vomiting 13.57 9.95 942 153780 211318 29208487
Cleft palate 13.55 9.95 16 154706 568 29419237
Ear disorder 13.41 9.95 24 154698 1250 29418555
Joint range of motion decreased 13.41 9.95 65 154657 5989 29413816
Altered state of consciousness 13.37 9.95 56 154666 19833 29399972
Arnold-Chiari malformation 13.31 9.95 12 154710 308 29419497
Grip strength decreased 13.29 9.95 34 154688 2273 29417532
Joint stiffness 13.26 9.95 90 154632 9383 29410422
Melaena 13.23 9.95 102 154620 31074 29388731
Neck mass 13.23 9.95 26 154696 1455 29418350
Spinal disorder 13.21 9.95 46 154676 3649 29416156
Bronchopulmonary aspergillosis 13.18 9.95 28 154694 12316 29407489
Malignant melanoma 13.17 9.95 73 154649 7088 29412717
Back disorder 13.13 9.95 64 154658 5909 29413896
Hernia pain 13.13 9.95 11 154711 255 29419550
Haemangioma 13.08 9.95 28 154694 1666 29418139
Impaired driving ability 13.06 9.95 34 154688 2297 29417508
Hypertriglyceridaemia 12.93 9.95 12 154710 7463 29412342
Umbilical hernia 12.93 9.95 46 154676 3689 29416116
Blood creatine phosphokinase increased 12.92 9.95 143 154579 40501 29379304
Myalgia 12.84 9.95 292 154430 73727 29346078
Vitamin B12 deficiency 12.83 9.95 42 154680 3229 29416576
Oesophageal adenocarcinoma 12.71 9.95 18 154704 767 29419038
Colitis ulcerative 12.69 9.95 112 154610 12657 29407148
Arthritis infective 12.68 9.95 38 154684 2786 29417019
Sensorimotor disorder 12.60 9.95 13 154709 396 29419409
Hypothyroidism 12.50 9.95 42 154680 15864 29403941
End stage renal disease 12.46 9.95 13 154709 7651 29412154
Tooth malformation 12.44 9.95 9 154713 167 29419638
Alcoholic liver disease 12.43 9.95 15 154707 545 29419260
Pulmonary artery stenosis congenital 12.43 9.95 14 154708 472 29419333
Hepatocellular injury 12.38 9.95 63 154659 21180 29398625
Anal atresia 12.38 9.95 11 154711 277 29419528
Foetal heart rate deceleration abnormality 12.36 9.95 14 154708 475 29419330
Respiratory rate increased 12.35 9.95 83 154639 8625 29411180
Wrong technique in product usage process 12.34 9.95 105 154617 31323 29388482
Contraindicated product administered 12.31 9.95 148 154574 18118 29401687
Radiation inflammation 12.30 9.95 10 154712 222 29419583
Chronic graft versus host disease 12.23 9.95 3 154719 4026 29415779
Cystitis haemorrhagic 12.22 9.95 5 154717 4837 29414968
Gun shot wound 12.15 9.95 21 154701 1064 29418741
Blood insulin increased 12.13 9.95 12 154710 347 29419458
Peripheral swelling 12.07 9.95 427 154295 63312 29356493
Foetal distress syndrome 12.07 9.95 20 154702 979 29418826
Blood parathyroid hormone decreased 12.04 9.95 18 154704 806 29418999
Developmental coordination disorder 12.04 9.95 9 154713 176 29419629
Poor venous access 11.87 9.95 40 154682 3121 29416684
Nephropathy toxic 11.82 9.95 24 154698 10732 29409073
Muscle spasms 11.79 9.95 255 154467 64827 29354978
Acute graft versus host disease 11.77 9.95 8 154714 5816 29413989
Ear malformation 11.71 9.95 11 154711 298 29419507
Haemorrhage intracranial 11.70 9.95 38 154684 14504 29405301
Neutrophil count decreased 11.68 9.95 159 154563 43408 29376397
BK virus infection 11.66 9.95 5 154717 4702 29415103
Ankylosing spondylitis 11.63 9.95 48 154674 4128 29415677
Palindromic rheumatism 11.62 9.95 9 154713 186 29419619
Opiates positive 11.61 9.95 14 154708 508 29419297
COVID-19 pneumonia 11.57 9.95 20 154702 9502 29410303
Immunodeficiency 11.56 9.95 50 154672 4390 29415415
Finger deformity 11.40 9.95 21 154701 1119 29418686
Pain in extremity 11.40 9.95 696 154026 109737 29310068
Pleural fibrosis 11.40 9.95 23 154699 1312 29418493
Gangrene neonatal 11.37 9.95 9 154713 192 29419613
Steatorrhoea 11.36 9.95 16 154706 678 29419127
Hallucination 11.34 9.95 165 154557 44547 29375258
No adverse event 11.26 9.95 50 154672 17428 29402377
Congenital hydronephrosis 11.20 9.95 16 154706 687 29419118
Psychomotor skills impaired 11.19 9.95 35 154687 2626 29417179
Inflammation 11.16 9.95 174 154548 22554 29397251
Red blood cell sedimentation rate increased 11.12 9.95 72 154650 7389 29412416
Obsessive-compulsive disorder 11.11 9.95 5 154717 4571 29415234
Excessive cerumen production 11.05 9.95 10 154712 258 29419547
Red blood cell sedimentation rate 10.95 9.95 14 154708 540 29419265
Peripheral artery thrombosis 10.93 9.95 30 154692 2092 29417713
Lung neoplasm malignant 10.88 9.95 119 154603 14238 29405567
C-reactive protein increased 10.87 9.95 306 154416 43957 29375848
Incorrect route of product administration 10.87 9.95 95 154627 10706 29409099
Gastrointestinal haemorrhage 10.82 9.95 325 154397 79208 29340597
Neonatal seizure 10.80 9.95 13 154709 471 29419334
Prescribed underdose 10.75 9.95 15 154707 7771 29412034
Meningeal disorder 10.74 9.95 11 154711 332 29419473
Neonatal infection 10.74 9.95 12 154710 401 29419404
Bezoar 10.71 9.95 17 154705 802 29419003
Non-Hodgkin's lymphoma 10.71 9.95 24 154698 1473 29418332
Therapy partial responder 10.70 9.95 7 154715 5192 29414613
Hyperkalaemia 10.70 9.95 242 154480 61150 29358655
Hyperbilirubinaemia 10.70 9.95 41 154681 14893 29404912
Hypoxia 10.62 9.95 179 154543 47200 29372605
Transplant rejection 10.61 9.95 20 154702 9192 29410613
Adenovirus infection 10.58 9.95 5 154717 4442 29415363
Diverticular perforation 10.54 9.95 37 154685 2947 29416858
Dermatitis acneiform 10.50 9.95 8 154714 5483 29414322
Ventricular tachycardia 10.48 9.95 72 154650 22502 29397303
Glycosylated haemoglobin increased 10.39 9.95 21 154701 9405 29410400
Haemolysis 10.29 9.95 67 154655 6889 29412916
Lip swelling 10.29 9.95 32 154690 12378 29407427
Haematocrit decreased 10.28 9.95 211 154511 28811 29390994
Pulmonary valve stenosis 10.27 9.95 11 154711 350 29419455
Alcoholic seizure 10.25 9.95 3 154719 4 29419801
Inguinal hernia 10.25 9.95 65 154657 6623 29413182
Fatty liver alcoholic 10.19 9.95 6 154716 77 29419728
Low set ears 10.18 9.95 12 154710 425 29419380
Dyslipidaemia 10.17 9.95 10 154712 6051 29413754
Pulmonary alveolar haemorrhage 10.17 9.95 11 154711 6369 29413436
Fine motor skill dysfunction 10.14 9.95 24 154698 1527 29418278
Drug eruption 10.13 9.95 49 154673 16692 29403113
Chronic kidney disease 10.09 9.95 132 154590 36284 29383521
Gastric haemorrhage 10.00 9.95 21 154701 9276 29410529
Hepatic failure 9.96 9.95 111 154611 31401 29388404

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1154.62 9.93 2958 410434 161336 63924004
Completed suicide 1137.61 9.93 3590 409802 220824 63864516
Drug abuse 786.45 9.93 2241 411151 130133 63955207
Pemphigus 751.16 9.93 1375 412017 59326 64026014
Systemic lupus erythematosus 721.84 9.93 1560 411832 76052 64009288
Arthropathy 718.61 9.93 2048 411344 118919 63966421
Hand deformity 693.81 9.93 1355 412037 61416 64023924
Joint swelling 674.43 9.93 2951 410441 212431 63872909
Synovitis 658.36 9.93 1748 411644 97342 63987998
Glossodynia 626.45 9.93 1322 412070 63374 64021966
Maternal exposure during pregnancy 581.65 9.93 1636 411756 94248 63991092
Arthralgia 541.25 9.93 4750 408642 437510 63647830
Infusion related reaction 532.57 9.93 2277 411115 162190 63923150
Anti-cyclic citrullinated peptide antibody positive 520.07 9.93 1047 412345 48515 64036825
Wound 506.74 9.93 1348 412044 75129 64010211
Pericarditis 483.01 9.93 1168 412224 61348 64023992
Toxicity to various agents 417.40 9.93 3852 409540 359661 63725679
Abdominal discomfort 382.32 9.93 2232 411160 180090 63905250
Pain 374.50 9.93 5289 408103 548222 63537118
Contraindicated product administered 355.06 9.93 1501 411891 106328 63979012
Alopecia 354.90 9.93 2040 411352 163650 63921690
Therapeutic product effect decreased 339.78 9.93 1553 411839 113798 63971542
Discomfort 335.50 9.93 1211 412181 79667 64005673
Swelling 332.97 9.93 1957 411435 158261 63927079
Nasopharyngitis 320.74 9.93 2254 411138 193819 63891521
Rheumatoid factor positive 309.57 9.93 689 412703 34249 64051091
Exposure during pregnancy 305.33 9.93 1143 412249 76532 64008808
Duodenal ulcer perforation 299.15 9.93 676 412716 33949 64051391
Helicobacter infection 296.52 9.93 717 412675 37645 64047695
Acute kidney injury 293.25 9.93 1685 411707 447555 63637785
Alcohol interaction 283.01 9.93 231 413161 4170 64081170
Febrile neutropenia 281.55 9.93 481 412911 187176 63898164
Drug intolerance 269.17 9.93 2094 411298 185898 63899442
Hepatic enzyme increased 261.41 9.93 1574 411818 128369 63956971
Musculoskeletal stiffness 253.98 9.93 1502 411890 121704 63963636
Drug interaction 238.29 9.93 1354 412038 360729 63724611
Cardio-respiratory arrest 223.44 9.93 1231 412161 97162 63988178
Psoriatic arthropathy 219.10 9.93 693 412699 42588 64042752
C-reactive protein abnormal 216.07 9.93 535 412857 28512 64056828
Impaired healing 187.57 9.93 827 412565 59646 64025694
Product use issue 180.81 9.93 1622 411770 150093 63935247
Sinusitis 179.51 9.93 1571 411821 144357 63940983
Red blood cell sedimentation rate abnormal 177.61 9.93 350 413042 15956 64069384
Lower respiratory tract infection 169.60 9.93 1113 412279 93501 63991839
Drug reaction with eosinophilia and systemic symptoms 165.43 9.93 70 413322 54147 64031193
Suspected suicide 162.70 9.93 237 413155 8417 64076923
Muscle injury 160.05 9.93 451 412941 25986 64059354
Sickle cell anaemia with crisis 159.96 9.93 184 413208 5148 64080192
Alcohol abuse 153.30 9.93 172 413220 4680 64080660
Cardiac failure 153.23 9.93 393 412999 131980 63953360
Blood pressure fluctuation 152.33 9.93 698 412694 51173 64034167
Bradycardia 151.97 9.93 332 413060 117887 63967453
Renal failure 148.43 9.93 629 412763 181059 63904281
Disease progression 146.65 9.93 444 412948 141236 63944104
Treatment failure 146.45 9.93 1263 412129 115553 63969787
Constipation 144.58 9.93 869 412523 228468 63856872
Peripheral swelling 144.45 9.93 2008 411384 207145 63878195
Folliculitis 143.53 9.93 472 412920 29605 64055735
Malignant neoplasm progression 143.42 9.93 319 413073 112552 63972788
Hypersensitivity 141.36 9.93 1900 411492 194552 63890788
Arthritis 140.04 9.93 969 412423 82845 64002495
Hip arthroplasty 139.94 9.93 375 413017 20976 64064364
Sleep disorder due to general medical condition, insomnia type 139.75 9.93 428 412964 25842 64059498
Neutropenia 138.24 9.93 933 412459 238691 63846649
Knee arthroplasty 137.27 9.93 433 412959 26566 64058774
Irritable bowel syndrome 136.19 9.93 537 412855 36832 64048508
Alcohol poisoning 134.72 9.93 151 413241 4104 64081236
Pregnancy 130.29 9.93 360 413032 20505 64064835
Hepatic function abnormal 126.60 9.93 135 413257 64178 64021162
Abortion spontaneous 118.57 9.93 393 412999 24750 64060590
Psoriasis 117.44 9.93 825 412567 70878 64014462
Drug resistance 109.22 9.93 44 413348 35058 64050282
Osteoarthritis 109.21 9.93 738 412654 62598 64022742
Death 108.21 9.93 2315 411077 480390 63604950
Hyponatraemia 107.77 9.93 536 412856 147803 63937537
Renal impairment 107.44 9.93 472 412920 134545 63950795
Cytomegalovirus infection 107.28 9.93 52 413340 37147 64048193
Product use in unapproved indication 106.71 9.93 678 412714 175940 63909400
Blister 105.45 9.93 883 412509 80084 64005256
Respiratory failure 104.05 9.93 606 412786 160577 63924763
Weight increased 103.57 9.93 1932 411460 211416 63873924
Injection site erythema 97.51 9.93 782 412610 70018 64015322
Enthesopathy 95.59 9.93 199 413193 9439 64075901
Anaemia 94.72 9.93 1783 411609 376897 63708443
Sedation 94.65 9.93 76 413316 41386 64043954
Ill-defined disorder 92.59 9.93 540 412852 43512 64041828
Multiple organ dysfunction syndrome 91.08 9.93 338 413054 101075 63984265
Alcohol use 90.86 9.93 129 413263 4473 64080867
Red blood cell sedimentation rate increased 89.98 9.93 418 412974 30817 64054523
Diarrhoea 88.29 9.93 3762 409630 718942 63366398
Lactic acidosis 86.96 9.93 163 413229 61247 64024093
Dyspnoea 86.33 9.93 3748 409644 714926 63370414
Drug ineffective 85.82 9.93 6368 407024 833879 63251461
Hyperglycaemia 85.31 9.93 163 413229 60805 64024535
Blood pressure systolic increased 85.11 9.93 576 412816 48877 64036463
Palmar-plantar erythrodysaesthesia syndrome 85.08 9.93 39 413353 28780 64056560
Infection 84.50 9.93 1659 411733 183221 63902119
Juvenile idiopathic arthritis 84.48 9.93 114 413278 3765 64081575
Contusion 84.28 9.93 1108 412284 112857 63972483
Live birth 83.98 9.93 207 413185 10997 64074343
Thrombocytopenia 82.86 9.93 976 412416 222825 63862515
Joint effusion 82.68 9.93 231 413161 13242 64072098
Injection site pruritus 82.31 9.93 468 412924 37358 64047982
Blood pressure diastolic abnormal 80.83 9.93 212 413180 11705 64073635
Cardiac failure congestive 79.50 9.93 500 412892 130080 63955260
Neoplasm progression 79.49 9.93 87 413305 40877 64044463
Device expulsion 79.16 9.93 19 413373 21117 64064223
Intentional product use issue 79.00 9.93 947 412445 94417 63990923
Rhabdomyolysis 78.32 9.93 312 413080 91414 63993926
Blood pressure systolic abnormal 78.06 9.93 187 413205 9755 64075585
Disability assessment scale score increased 77.06 9.93 88 413304 2442 64082898
Rheumatic fever 76.44 9.93 178 413214 9116 64076224
Hypoglycaemia 75.97 9.93 307 413085 89585 63995755
Rheumatoid nodule 73.82 9.93 213 413179 12438 64072902
Asthenia 73.81 9.93 2134 411258 425910 63659430
Injection site pain 71.40 9.93 1056 412336 110352 63974988
Swollen joint count increased 70.76 9.93 154 413238 7535 64077805
Angioedema 70.38 9.93 185 413207 61636 64023704
Depressed level of consciousness 70.16 9.93 276 413116 81160 64004180
Caesarean section 69.87 9.93 194 413198 11080 64074260
Tenosynovitis 69.80 9.93 200 413192 11633 64073707
Osteoporosis 68.78 9.93 484 412908 41596 64043744
Grip strength decreased 68.03 9.93 197 413195 11527 64073813
Neuropathy peripheral 67.49 9.93 458 412934 117067 63968273
Injection site reaction 66.21 9.93 519 412873 46145 64039195
Nausea 66.14 9.93 4247 409145 781553 63303787
Syncope 66.09 9.93 668 412724 156967 63928373
Injection site swelling 65.48 9.93 472 412920 40881 64044459
Blood pressure diastolic decreased 65.38 9.93 300 413092 22001 64063339
Joint laxity 64.66 9.93 77 413315 2237 64083103
Decreased appetite 64.06 9.93 1345 412047 279944 63805396
Fibromyalgia 63.78 9.93 420 412972 35311 64050029
Intentional overdose 63.40 9.93 867 412525 89077 63996263
Heart rate decreased 62.61 9.93 583 412809 54484 64030856
Foot deformity 62.43 9.93 240 413152 16264 64069076
Cerebral haemorrhage 61.96 9.93 148 413244 50942 64034398
Disseminated intravascular coagulation 61.34 9.93 70 413322 32278 64053062
Immune reconstitution inflammatory syndrome 61.07 9.93 5 413387 12465 64072875
Hypotension 60.54 9.93 1920 411472 379054 63706286
Cholestasis 60.16 9.93 123 413269 44749 64040591
Serotonin syndrome 59.46 9.93 100 413292 39182 64046158
Hepatic failure 59.15 9.93 171 413221 55223 64030117
Hyperkalaemia 59.12 9.93 392 413000 100737 63984603
Dizziness 59.08 9.93 2208 411184 427955 63657385
Musculoskeletal pain 58.69 9.93 787 412605 80507 64004833
Diabetic ketoacidosis 58.34 9.93 63 413329 29782 64055558
Hypoxia 58.14 9.93 329 413063 87820 63997520
Blood alcohol increased 57.68 9.93 53 413339 1129 64084211
Myocardial infarction 57.24 9.93 734 412658 165087 63920253
Dehydration 56.80 9.93 1012 412380 215751 63869589
Gestational diabetes 56.12 9.93 116 413276 5474 64079866
Myalgia 55.91 9.93 699 412693 157918 63927422
Joint stiffness 55.86 9.93 360 413032 30044 64055296
Hepatocellular injury 54.89 9.93 131 413261 45104 64040236
Leukopenia 54.48 9.93 402 412990 100840 63984500
Bone erosion 53.56 9.93 180 413212 11415 64073925
Localised infection 53.51 9.93 354 413038 29807 64055533
Pyrexia 53.32 9.93 2983 410409 555661 63529679
Pulmonary embolism 53.08 9.93 641 412751 145715 63939625
Polyarthritis 52.34 9.93 159 413233 9556 64075784
Encephalopathy 52.17 9.93 197 413195 58622 64026718
Neutrophil count decreased 51.52 9.93 287 413105 76909 64008431
Tongue disorder 50.14 9.93 181 413211 11899 64073441
Vomiting 50.02 9.93 2957 410435 548160 63537180
Condition aggravated 49.74 9.93 2889 410503 369537 63715803
Neuroleptic malignant syndrome 49.71 9.93 52 413340 24944 64060396
C-reactive protein increased 49.69 9.93 870 412522 94039 63991301
Infective pulmonary exacerbation of cystic fibrosis 49.64 9.93 8 413384 11788 64073552
Basal cell carcinoma 49.41 9.93 353 413039 30485 64054855
Multiple sclerosis relapse 49.22 9.93 120 413272 41015 64044325
Injection site bruising 49.11 9.93 400 412992 35973 64049367
Blood pressure diastolic increased 48.86 9.93 166 413226 10586 64074754
Blood pressure increased 48.84 9.93 1450 411942 171102 63914238
Blood glucose increased 48.75 9.93 398 412994 97675 63987665
Sedation complication 48.44 9.93 5 413387 10349 64074991
Inflammation 48.31 9.93 635 412757 64665 64020675
Pain in extremity 48.01 9.93 2389 411003 300696 63784644
Orthostatic hypotension 47.94 9.93 147 413245 46591 64038749
Urticaria 47.24 9.93 662 412730 146655 63938685
Sepsis 47.11 9.93 1120 412272 229221 63856119
Tremor 46.16 9.93 670 412722 147560 63937780
Pulmonary arterial hypertension 45.85 9.93 57 413335 25310 64060030
Gastrointestinal disorder 45.78 9.93 819 412573 88890 63996450
Fluid retention 45.22 9.93 212 413180 59394 64025946
Anaphylactic shock 45.18 9.93 78 413314 30250 64055090
Off label use 45.09 9.93 3469 409923 629337 63456003
Fatigue 45.04 9.93 5467 407925 743263 63342077
Asthma 44.83 9.93 392 413000 94833 63990507
Femur fracture 44.81 9.93 373 413019 33762 64051578
Blood creatinine increased 44.67 9.93 607 412785 135175 63950165
Respiratory distress 44.66 9.93 178 413214 52153 64033187
Loss of personal independence in daily activities 44.55 9.93 682 412710 71772 64013568
Anxiety 44.35 9.93 975 412417 201674 63883666
Neurotoxicity 44.08 9.93 67 413325 27337 64058003
Rash maculo-papular 44.02 9.93 154 413238 46872 64038468
Venoocclusive liver disease 43.97 9.93 6 413386 10009 64075331
Melaena 43.91 9.93 185 413207 53363 64031977
Gastrointestinal haemorrhage 43.70 9.93 591 412801 131721 63953619
Body temperature decreased 43.42 9.93 300 413092 25628 64059712
Exposure to toxic agent 43.24 9.93 111 413281 6048 64079292
Posterior reversible encephalopathy syndrome 43.14 9.93 50 413342 22896 64062444
Premature delivery 43.11 9.93 234 413158 18355 64066985
Cytokine release syndrome 42.94 9.93 42 413350 20787 64064553
Tendonitis 42.85 9.93 249 413143 20033 64065307
Delirium 42.58 9.93 264 413128 68930 64016410
Atrial fibrillation 42.54 9.93 806 412586 170283 63915057
Pre-eclampsia 42.41 9.93 111 413281 6120 64079220
Drug hypersensitivity 42.32 9.93 1180 412212 236635 63848705
Ascites 42.20 9.93 229 413163 61772 64023568
Joint destruction 41.98 9.93 80 413312 3556 64081784
Altered state of consciousness 41.95 9.93 115 413277 37787 64047553
Maternal exposure before pregnancy 41.91 9.93 78 413314 3405 64081935
Hypokalaemia 41.90 9.93 540 412852 121363 63963977
Hyperhidrosis 41.61 9.93 557 412835 124363 63960977
Neck deformity 41.44 9.93 53 413339 1659 64083681
Product quality issue 41.39 9.93 80 413312 29719 64055621
Synovial cyst 41.39 9.93 126 413266 7581 64077759
Rash 41.25 9.93 3443 409949 455106 63630234
Injection site rash 41.24 9.93 205 413187 15537 64069803
Agranulocytosis 40.82 9.93 118 413274 38111 64047229
Proteinuria 40.66 9.93 72 413320 27651 64057689
White blood cell count decreased 40.34 9.93 740 412652 157097 63928243
Nodule 40.33 9.93 224 413168 17723 64067617
Cerebral infarction 40.06 9.93 132 413260 40912 64044428
Cognitive disorder 40 9.93 199 413193 54888 64030452
Aspergillus infection 39.98 9.93 28 413364 16351 64068989
Vision blurred 39.82 9.93 378 413014 89938 63995402
Oropharyngeal pain 39.73 9.93 795 412597 88072 63997268
Inappropriate antidiuretic hormone secretion 39.34 9.93 51 413341 22238 64063102
Second primary malignancy 39.14 9.93 15 413377 12322 64073018
Fracture 38.81 9.93 229 413163 18526 64066814
Speech disorder 38.71 9.93 169 413223 48272 64037068
Cerebrovascular accident 38.71 9.93 634 412758 136949 63948391
Drug ineffective for unapproved indication 38.70 9.93 89 413303 31044 64054296
Pathogen resistance 38.57 9.93 16 413376 12527 64072813
Pulmonary fibrosis 38.43 9.93 325 413067 29553 64055787
Red blood cell sedimentation rate 38.38 9.93 78 413314 3636 64081704
Electrocardiogram QT prolonged 37.87 9.93 326 413066 79122 64006218
Alanine aminotransferase abnormal 37.36 9.93 113 413279 6775 64078565
Muscle spasms 37.36 9.93 657 412735 140366 63944974
Blood creatine phosphokinase increased 37.30 9.93 221 413171 58337 64027003
Anaphylactic reaction 37.24 9.93 272 413120 68392 64016948
Deep vein thrombosis 37.24 9.93 463 412929 104719 63980621
Platelet count decreased 37.23 9.93 805 412587 166906 63918434
Tenderness 37.18 9.93 234 413158 19368 64065972
Transplant rejection 37.15 9.93 34 413358 17367 64067973
Premature rupture of membranes 36.77 9.93 77 413315 3667 64081673
Premature labour 36.72 9.93 120 413272 7500 64077840
Disability 36.62 9.93 165 413227 12007 64073333
Bronchopulmonary aspergillosis 36.51 9.93 41 413351 19044 64066296
Limb deformity 36.43 9.93 72 413320 3289 64082051
Chronic kidney disease 36.15 9.93 220 413172 57699 64027641
Ischaemic stroke 36.09 9.93 83 413309 28952 64056388
Pleural effusion 35.67 9.93 583 412809 125976 63959364
Haemoptysis 35.15 9.93 178 413214 48870 64036470
Laryngitis 35.05 9.93 152 413240 10879 64074461
Hallucination 34.99 9.93 298 413094 72490 64012850
Neck mass 34.97 9.93 79 413313 3965 64081375
Osteonecrosis of jaw 34.92 9.93 134 413258 39691 64045649
Joint range of motion decreased 34.90 9.93 228 413164 19115 64066225
Smear cervix abnormal 34.83 9.93 58 413334 2316 64083024
Eosinophilia 34.77 9.93 126 413266 37950 64047390
Stomatitis 34.32 9.93 933 412459 108672 63976668
Haematotoxicity 34.28 9.93 20 413372 12876 64072464
Status epilepticus 33.86 9.93 54 413338 21609 64063731
Mental status changes 33.79 9.93 241 413151 60921 64024419
Joint injury 33.53 9.93 257 413135 22690 64062650
Substance abuse 33.42 9.93 133 413259 9159 64076181
Intentional product misuse 33.41 9.93 650 412742 71645 64013695
Ejection fraction decreased 33.36 9.93 85 413307 28622 64056718
Toxic epidermal necrolysis 33.27 9.93 124 413268 37042 64048298
Extrapyramidal disorder 33.22 9.93 46 413346 19506 64065834
Emotional distress 33.07 9.93 119 413273 35919 64049421
Dysgeusia 33.00 9.93 172 413220 46875 64038465
Coronary artery disease 32.97 9.93 239 413153 60194 64025146
Tuberculosis 32.90 9.93 168 413224 12870 64072470
Poor venous access 32.74 9.93 162 413230 12255 64073085
Torsade de pointes 32.46 9.93 38 413354 17325 64068015
Acute graft versus host disease 32.42 9.93 9 413383 9075 64076265
Arthritis infective 32.35 9.93 109 413283 6921 64078419
Latent tuberculosis 32.25 9.93 61 413331 2696 64082644
Unintentional medical device removal 32.16 9.93 3 413389 6731 64078609
Clostridium difficile colitis 32.11 9.93 80 413312 27143 64058197
Multiple fractures 31.74 9.93 98 413294 5942 64079398
Thrombotic microangiopathy 31.62 9.93 36 413356 16619 64068721
Ventricular tachycardia 31.54 9.93 113 413279 34152 64051188
BK virus infection 31.25 9.93 5 413387 7407 64077933
Subdural haematoma 31.13 9.93 85 413307 27969 64057371
Haemorrhage 30.91 9.93 342 413050 79009 64006331
Erythema multiforme 30.84 9.93 33 413359 15668 64069672
Tumour lysis syndrome 30.82 9.93 48 413344 19392 64065948
Haemorrhage intracranial 30.73 9.93 67 413325 23817 64061523
Graft versus host disease 30.68 9.93 26 413366 13787 64071553
Balance disorder 30.63 9.93 367 413025 83559 64001781
Sopor 30.62 9.93 93 413299 29568 64055772
No adverse event 30.61 9.93 88 413304 28473 64056867
Forced expiratory volume decreased 30.42 9.93 4 413388 6863 64078477
Tenosynovitis stenosans 30.26 9.93 49 413343 1911 64083429
Fear of injection 30.21 9.93 95 413297 5817 64079523
Skin ulcer 30.21 9.93 422 412970 43552 64041788
Herpes zoster 30.11 9.93 692 412700 78495 64006845
Chest pain 29.97 9.93 1222 412170 234758 63850582
Oral herpes 29.58 9.93 243 413149 21909 64063431
Wheelchair user 29.55 9.93 81 413311 4591 64080749
Ulcer 29.53 9.93 250 413142 22740 64062600
Disturbance in attention 29.46 9.93 149 413243 40925 64044415
Dyspnoea exertional 29.42 9.93 316 413076 73414 64011926
Stevens-Johnson syndrome 28.91 9.93 117 413275 34132 64051208
Respiratory disorder 28.84 9.93 126 413266 35985 64049355
Spinal stenosis 28.76 9.93 170 413222 13761 64071579
Bone disorder 28.70 9.93 195 413197 16564 64068776
Creatinine renal clearance decreased 28.68 9.93 30 413362 14391 64070949
Skin cancer 28.63 9.93 152 413240 11822 64073518
Irritability 28.28 9.93 130 413262 36616 64048724
Blood alkaline phosphatase increased 28.14 9.93 228 413164 56051 64029289
Arrhythmia 28.10 9.93 211 413181 52733 64032607
Shock haemorrhagic 28.04 9.93 40 413352 16751 64068589
Skin papilloma 27.88 9.93 85 413307 5118 64080222
Immunodeficiency 27.85 9.93 188 413204 15936 64069404
Toxic skin eruption 27.46 9.93 51 413341 19233 64066107
Jaundice 27.36 9.93 190 413202 48322 64037018
Myoclonus 27.21 9.93 77 413315 25041 64060299
Acute generalised exanthematous pustulosis 27.11 9.93 30 413362 14028 64071312
Joint noise 26.96 9.93 62 413330 3149 64082191
Vertigo 26.86 9.93 245 413147 58766 64026574
Mouth ulceration 26.77 9.93 322 413070 32122 64053218
Chest discomfort 26.72 9.93 554 412838 115552 63969788
Septic shock 26.72 9.93 495 412897 104942 63980398
Synovial fluid analysis 26.68 9.93 41 413351 1528 64083812
Rotator cuff repair 26.66 9.93 40 413352 1459 64083881
Alcohol withdrawal syndrome 26.39 9.93 44 413348 1759 64083581
Acute myeloid leukaemia 26.33 9.93 89 413303 27374 64057966
Hyperbilirubinaemia 26.05 9.93 61 413331 21144 64064196
Acute respiratory failure 26.03 9.93 200 413192 49734 64035606
Hypertransaminasaemia 25.90 9.93 7 413385 7184 64078156
Postmortem blood drug level abnormal 25.88 9.93 26 413366 621 64084719
Angina pectoris 25.71 9.93 176 413216 44905 64040435
Hypomagnesaemia 25.46 9.93 138 413254 37238 64048102
Loose body in joint 25.32 9.93 35 413357 1183 64084157
Febrile bone marrow aplasia 25.23 9.93 21 413371 11234 64074106
Ear infection 25.21 9.93 245 413147 23159 64062181
Bone pain 25.06 9.93 190 413202 47382 64037958
Glycosylated haemoglobin increased 24.97 9.93 40 413352 15979 64069361
Tachypnoea 24.88 9.93 87 413305 26484 64058856
Acute chest syndrome 24.81 9.93 30 413362 886 64084454
Pulmonary hypertension 24.81 9.93 168 413224 42971 64042369
Malignant melanoma 24.74 9.93 155 413237 12809 64072531
Foetal death 24.74 9.93 89 413303 5841 64079499
Pemphigoid 24.73 9.93 28 413364 12958 64072382
Foot fracture 24.68 9.93 200 413192 17957 64067383
Maternal exposure timing unspecified 24.66 9.93 54 413338 2653 64082687
Surgery 24.60 9.93 283 413109 27930 64057410
Wrong technique in product usage process 24.53 9.93 282 413110 64692 64020648
Injection site warmth 24.48 9.93 159 413233 13303 64072037
Blood bilirubin increased 24.47 9.93 243 413149 57310 64028030
Bradyphrenia 24.42 9.93 15 413377 9391 64075949
Interstitial lung disease 24.40 9.93 460 412932 97272 63988068
Pain in jaw 24.30 9.93 157 413235 40598 64044742
Tachycardia 24.13 9.93 752 412640 148827 63936513
Acute graft versus host disease in skin 24.08 9.93 7 413385 6848 64078492
Gamma-glutamyltransferase increased 24.04 9.93 197 413195 48313 64037027
Therapeutic response decreased 24.03 9.93 469 412923 51719 64033621
Gastroenteritis viral 24.01 9.93 212 413180 19517 64065823
Fear 24.01 9.93 59 413333 20112 64065228
Bronchospasm 23.83 9.93 66 413326 21616 64063724
Polyneuropathy 23.82 9.93 58 413334 19836 64065504
Ventricular fibrillation 23.79 9.93 76 413316 23784 64061556
Blood parathyroid hormone decreased 23.79 9.93 102 413290 7264 64078076
Hypothermia 23.69 9.93 58 413334 19798 64065542
Bronchitis 23.63 9.93 886 412506 107857 63977483
Lipase increased 23.37 9.93 35 413357 14367 64070973
Metastases to bone 23.37 9.93 61 413331 20374 64064966
Leukocytosis 23.21 9.93 144 413248 37596 64047744
Pancreatitis 23.17 9.93 257 413135 59350 64025990
Blood cholesterol increased 23.08 9.93 450 412942 49616 64035724
Haemophagocytic lymphohistiocytosis 22.98 9.93 49 413343 17560 64067780
Klebsiella infection 22.81 9.93 31 413361 13250 64072090
Polyhydramnios 22.72 9.93 37 413355 1450 64083890
Abdominal distension 22.69 9.93 456 412936 95538 63989802
Influenza 22.68 9.93 866 412526 105665 63979675
Dystonia 22.59 9.93 55 413337 18810 64066530
Cardiac failure acute 22.59 9.93 44 413348 16300 64069040
Dermatitis acneiform 22.58 9.93 13 413379 8430 64076910
Face oedema 22.56 9.93 82 413310 24679 64060661
Muscle rigidity 22.49 9.93 49 413343 17424 64067916
Fracture delayed union 22.09 9.93 43 413349 1942 64083398
Urinary retention 22.08 9.93 205 413187 48996 64036344
Tardive dyskinesia 22.00 9.93 16 413376 9162 64076178
Disorientation 21.98 9.93 240 413152 55588 64029752
Cytopenia 21.95 9.93 41 413351 15430 64069910
Dyskinesia 21.85 9.93 155 413237 39233 64046107
Endophthalmitis 21.78 9.93 4 413388 5361 64079979
Psychotic disorder 21.76 9.93 131 413261 34447 64050893
Acute myocardial infarction 21.73 9.93 315 413077 69403 64015937
Dysphagia 21.63 9.93 520 412872 106292 63979048
Flushing 21.59 9.93 364 413028 78284 64007056
Cardiac arrest 21.48 9.93 789 412603 153275 63932065
Muscular weakness 21.32 9.93 637 412755 126701 63958639
Antinuclear antibody positive 21.32 9.93 88 413304 6162 64079178
International normalised ratio increased 21.22 9.93 368 413024 78799 64006541
Adenovirus infection 21.13 9.93 10 413382 7245 64078095
Stress cardiomyopathy 21.09 9.93 17 413375 9240 64076100
Post procedural infection 21.05 9.93 119 413273 9478 64075862
Stillbirth 21.03 9.93 61 413331 3572 64081768
Cytomegalovirus viraemia 21.00 9.93 23 413369 10805 64074535
Chronic graft versus host disease 20.99 9.93 7 413385 6269 64079071
Psychomotor hyperactivity 20.77 9.93 38 413354 14413 64070927
Nocardiosis 20.59 9.93 3 413389 4764 64080576
Hyperthermia 20.52 9.93 43 413349 15507 64069833
Agitation 20.52 9.93 421 412971 87946 63997394
Hyperuricaemia 20.49 9.93 21 413371 10170 64075170
Alcoholism 20.39 9.93 58 413334 3359 64081981
Scleritis 20.35 9.93 53 413339 2913 64082427
Acute coronary syndrome 20.33 9.93 60 413332 19250 64066090
Metastases to lung 20.32 9.93 42 413350 15222 64070118
Granuloma skin 20.31 9.93 85 413307 5989 64079351
Cystitis haemorrhagic 20.23 9.93 13 413379 7943 64077397
Haematoma 20.20 9.93 194 413198 46056 64039284
Labelled drug-drug interaction medication error 20.14 9.93 73 413319 21989 64063351
Aspartate aminotransferase increased 20.11 9.93 599 412793 119189 63966151
Rhinorrhoea 20.06 9.93 515 412877 59454 64025886
Coagulopathy 20.05 9.93 121 413271 31799 64053541
Postoperative wound infection 19.99 9.93 124 413268 10212 64075128
Device difficult to use 19.92 9.93 20 413372 9778 64075562
Feeling abnormal 19.81 9.93 679 412713 132923 63952417
Plasma cell myeloma 19.81 9.93 194 413198 45881 64039459
Somnolence 19.78 9.93 1085 412307 202560 63882780
Palpitations 19.72 9.93 514 412878 103974 63981366
Pulmonary alveolar haemorrhage 19.66 9.93 20 413372 9718 64075622
Hypervolaemia 19.65 9.93 154 413238 38131 64047209
Epstein-Barr virus infection 19.64 9.93 31 413361 12457 64072883
Seizure 19.55 9.93 872 412520 166020 63919320
Tubulointerstitial nephritis 19.50 9.93 117 413275 30792 64054548
Disease recurrence 19.50 9.93 120 413272 31390 64053950
Lip swelling 19.49 9.93 122 413270 31785 64053555
Metastases to liver 19.45 9.93 83 413309 23858 64061482
Aphasia 19.42 9.93 168 413224 40738 64044602
Panniculitis 19.41 9.93 110 413282 8769 64076571
Synovial disorder 19.35 9.93 27 413365 921 64084419
Cardiomyopathy 19.34 9.93 90 413302 25266 64060074
Cardiogenic shock 19.29 9.93 125 413267 32302 64053038
Dactylitis 19.20 9.93 40 413352 1898 64083442
Diabetes insipidus 19.17 9.93 3 413389 4518 64080822
Breast feeding 19.16 9.93 23 413369 674 64084666
Hypocalcaemia 19.15 9.93 173 413219 41580 64043760
Acute hepatic failure 19.14 9.93 94 413298 26018 64059322
Hospitalisation 19.08 9.93 353 413039 74854 64010486
Insomnia 19.04 9.93 1055 412337 196781 63888559
Presyncope 19.02 9.93 139 413253 34950 64050390
Pneumatosis intestinalis 19.00 9.93 5 413387 5224 64080116
Lymphocyte count decreased 18.94 9.93 168 413224 40531 64044809
Cardiac failure chronic 18.90 9.93 18 413374 9023 64076317
Muscle spasticity 18.88 9.93 50 413342 16619 64068721
Anhedonia 18.86 9.93 37 413355 13669 64071671
Nephropathy toxic 18.74 9.93 54 413338 17460 64067880
Device use error 18.73 9.93 9 413383 6462 64078878
Pharyngitis streptococcal 18.69 9.93 107 413285 8561 64076779
Endodontic procedure 18.57 9.93 44 413348 2279 64083061
Hypoalbuminaemia 18.54 9.93 55 413337 17619 64067721
Bacteraemia 18.53 9.93 99 413293 26812 64058528
Oedema 18.49 9.93 448 412944 91487 63993853
Haemorrhage in pregnancy 18.42 9.93 31 413361 1249 64084091
Hypophosphataemia 18.36 9.93 42 413350 14678 64070662
Oxygen saturation decreased 18.23 9.93 851 412541 106325 63979015
Peripheral sensory neuropathy 18.13 9.93 28 413364 11350 64073990
Atrioventricular block complete 18.09 9.93 41 413351 14377 64070963
Product prescribing error 18.04 9.93 142 413250 35127 64050213
Gastric haemorrhage 18.03 9.93 37 413355 13444 64071896
Acute respiratory distress syndrome 18.00 9.93 161 413231 38774 64046566
Respiration abnormal 17.95 9.93 9 413383 6306 64079034
Coronary arterial stent insertion 17.93 9.93 7 413385 5685 64079655
Obstructive airways disorder 17.85 9.93 82 413310 23103 64062237
Oedema peripheral 17.85 9.93 1135 412257 209182 63876158
Pseudomonas infection 17.80 9.93 57 413335 17826 64067514
Foetal distress syndrome 17.78 9.93 18 413374 434 64084906
Shock 17.73 9.93 158 413234 38082 64047258
Right ventricular failure 17.71 9.93 74 413318 21397 64063943
Joint dislocation 17.65 9.93 130 413262 11335 64074005
Blood pressure decreased 17.63 9.93 419 412973 85780 63999560
Normal newborn 17.54 9.93 77 413315 5540 64079800
Visual acuity reduced 17.51 9.93 102 413290 27039 64058301
Human antichimeric antibody positive 17.40 9.93 32 413360 1384 64083956
Pancreatitis acute 17.37 9.93 183 413209 42672 64042668
Hyperammonaemia 17.13 9.93 23 413369 9881 64075459
Induced labour 17.12 9.93 24 413368 822 64084518
Arthritis bacterial 17.06 9.93 97 413295 7742 64077598
Ingrown hair 17.04 9.93 20 413372 572 64084768
Pneumothorax 16.94 9.93 89 413303 24209 64061131
Restlessness 16.90 9.93 168 413224 39617 64045723
Pancytopenia 16.89 9.93 1100 412292 142209 63943131
Hyperthyroidism 16.70 9.93 60 413332 18119 64067221
Pulmonary tuberculosis 16.67 9.93 91 413301 7153 64078187
Placental disorder 16.61 9.93 24 413368 846 64084494
Lacrimal disorder 16.54 9.93 18 413374 473 64084867
Blood calcium decreased 16.51 9.93 96 413296 25458 64059882
Skin exfoliation 16.48 9.93 196 413196 44689 64040651
Myopathy 16.48 9.93 58 413334 17622 64067718
End stage renal disease 16.48 9.93 26 413366 10449 64074891
Dyslipidaemia 16.46 9.93 21 413371 9221 64076119
Depression 16.45 9.93 984 412408 182307 63903033
Sinus bradycardia 16.45 9.93 83 413309 22810 64062530
Affective disorder 16.39 9.93 11 413381 6569 64078771
Hepatitis fulminant 16.30 9.93 10 413382 6264 64079076
Hemiplegia 16.27 9.93 36 413356 12732 64072608
Blood loss anaemia 16.25 9.93 41 413351 13851 64071489
Myelosuppression 16.22 9.93 88 413304 23742 64061598
Cyanosis 16.10 9.93 80 413312 22075 64063265
Exostosis 16.10 9.93 127 413265 11311 64074029
Cyst 16.09 9.93 132 413260 11895 64073445
Mobility decreased 16.00 9.93 688 412704 85152 64000188
Anuria 15.87 9.93 65 413327 18899 64066441
Purpura 15.79 9.93 57 413335 17189 64068151
Road traffic accident 15.78 9.93 281 413111 30464 64054876
Hepatitis cholestatic 15.72 9.93 34 413358 12121 64073219
Pneumonia bacterial 15.62 9.93 47 413345 14988 64070352
Metastases to central nervous system 15.55 9.93 42 413350 13870 64071470
Cytomegalovirus chorioretinitis 15.54 9.93 6 413386 4906 64080434
Drug withdrawal syndrome 15.54 9.93 127 413265 31164 64054176
Bursitis 15.50 9.93 208 413184 21277 64064063
Renal injury 15.49 9.93 49 413343 15380 64069960
Lupus-like syndrome 15.48 9.93 103 413289 8688 64076652
Rash erythematous 15.41 9.93 219 413173 48414 64036926
Temperature regulation disorder 15.35 9.93 4 413388 4207 64081133
Device related infection 15.34 9.93 124 413268 30502 64054838
Metabolic acidosis 15.33 9.93 342 413050 70616 64014724
Generalised oedema 15.33 9.93 75 413317 20778 64064562
Adverse event 15.29 9.93 346 413046 39143 64046197
Taste disorder 15.23 9.93 23 413369 9410 64075930
Enterocolitis 15.22 9.93 34 413358 11984 64073356
Cushingoid 15.20 9.93 92 413300 7511 64077829
Body height below normal 15.15 9.93 35 413357 1783 64083557
Abnormal behaviour 15.12 9.93 140 413252 33482 64051858
Placental insufficiency 15.07 9.93 25 413367 995 64084345
Hepatocellular carcinoma 15.06 9.93 19 413373 8384 64076956
Potentiating drug interaction 14.88 9.93 17 413375 7835 64077505
Dislocation of vertebra 14.88 9.93 49 413343 3075 64082265
Bone density abnormal 14.86 9.93 45 413347 2700 64082640
Toxic encephalopathy 14.84 9.93 25 413367 9790 64075550
COVID-19 pneumonia 14.81 9.93 55 413337 16449 64068891
Lung transplant 14.79 9.93 4 413388 4104 64081236
Eosinophil count increased 14.75 9.93 44 413348 14068 64071272
Gestational hypertension 14.71 9.93 33 413359 1648 64083692
COVID-19 14.63 9.93 312 413080 64828 64020512
Graft versus host disease in skin 14.63 9.93 8 413384 5339 64080001
Lymphatic fistula 14.60 9.93 21 413371 737 64084603
Hyperprolactinaemia 14.56 9.93 4 413388 4061 64081279
Femoral hernia incarcerated 14.54 9.93 21 413371 740 64084600
Foetal exposure during pregnancy 14.47 9.93 62 413330 4414 64080926
Dry eye 14.46 9.93 264 413128 28755 64056585
Ileus 14.45 9.93 87 413305 22879 64062461
Wound infection pseudomonas 14.45 9.93 31 413361 1502 64083838
Transplant dysfunction 14.45 9.93 13 413379 6695 64078645
Diabetes mellitus inadequate control 14.37 9.93 79 413313 21242 64064098
Haematuria 14.37 9.93 287 413105 60184 64025156
Tooth infection 14.36 9.93 150 413242 14451 64070889
Heparin-induced thrombocytopenia 14.35 9.93 20 413372 8459 64076881
Amylase increased 14.34 9.93 25 413367 9660 64075680
Cervical incompetence 14.25 9.93 17 413375 495 64084845
Akathisia 14.23 9.93 33 413359 11477 64073863
Polydipsia 14.14 9.93 10 413382 5811 64079529
Mass 14.12 9.93 155 413237 15121 64070219
Ileus paralytic 14.10 9.93 20 413372 8395 64076945
Unevaluable event 14.08 9.93 233 413159 50256 64035084
Spinal disorder 14.06 9.93 100 413292 8622 64076718
Hypothyroidism 13.97 9.93 179 413213 40278 64045062
Hemiparesis 13.94 9.93 123 413269 29704 64055636
Renal disorder 13.93 9.93 152 413240 35213 64050127
Unresponsive to stimuli 13.90 9.93 233 413159 50160 64035180
Nephrotic syndrome 13.89 9.93 25 413367 9542 64075798
Iodine allergy 13.82 9.93 17 413375 511 64084829
Maternal exposure during breast feeding 13.81 9.93 36 413356 1980 64083360
Hepatitis acute 13.81 9.93 42 413350 13347 64071993
Pleuritic pain 13.74 9.93 94 413298 8002 64077338
Hepatic encephalopathy 13.68 9.93 79 413313 20987 64064353
Malignant mediastinal neoplasm 13.67 9.93 17 413375 517 64084823
Abortion threatened 13.67 9.93 15 413377 398 64084942
Hyperlactacidaemia 13.62 9.93 7 413385 4837 64080503
Tuberculin test positive 13.62 9.93 47 413345 3021 64082319
Sickle cell anaemia 13.58 9.93 18 413374 584 64084756
Prostatic specific antigen increased 13.54 9.93 22 413370 8738 64076602
Injection site urticaria 13.53 9.93 120 413272 11061 64074279
Frequent bowel movements 13.53 9.93 178 413214 18127 64067213
Polyuria 13.52 9.93 39 413353 12604 64072736
Glomerular filtration rate decreased 13.47 9.93 72 413320 19500 64065840
Hypernatraemia 13.47 9.93 37 413355 12152 64073188
Dementia 13.42 9.93 78 413314 20688 64064652
Diabetes mellitus 13.35 9.93 324 413068 66150 64019190
Persecutory delusion 13.28 9.93 5 413387 4153 64081187
Hypercapnia 13.17 9.93 18 413374 7676 64077664
Joint lock 13.12 9.93 44 413348 2787 64082553
Colitis microscopic 13.12 9.93 17 413375 7415 64077925
Ankle arthroplasty 13.11 9.93 22 413370 884 64084456
Colitis ulcerative 13.10 9.93 214 413178 22814 64062526
Drug level increased 13.07 9.93 148 413244 34048 64051292
Clear cell renal cell carcinoma 13.02 9.93 37 413355 2142 64083198
Complication of device insertion 13.00 9.93 8 413384 5004 64080336
Hypophagia 12.99 9.93 177 413215 39410 64045930
Blood ethanol 12.94 9.93 9 413383 126 64085214
Small for dates baby 12.92 9.93 15 413377 424 64084916
Threatened labour 12.91 9.93 17 413375 548 64084792
Hallucination, visual 12.91 9.93 115 413277 27719 64057621
Blood urea increased 12.90 9.93 202 413190 43951 64041389
Atrioventricular block 12.89 9.93 37 413355 11978 64073362
Uterine perforation 12.87 9.93 11 413381 5809 64079531
Immunosuppression 12.83 9.93 115 413277 10631 64074709
Rheumatoid lung 12.82 9.93 40 413352 2439 64082901
Intestinal ischaemia 12.81 9.93 35 413357 11514 64073826
Kidney transplant rejection 12.81 9.93 26 413366 9485 64075855
Cholestasis of pregnancy 12.78 9.93 22 413370 903 64084437
Musculoskeletal disorder 12.77 9.93 173 413219 17733 64067607
Genital haemorrhage 12.75 9.93 10 413382 5512 64079828
Palindromic rheumatism 12.72 9.93 13 413379 317 64085023
Alanine aminotransferase increased 12.72 9.93 745 412647 138286 63947054
Human anti-human antibody test 12.68 9.93 14 413378 374 64084966
Brain oedema 12.67 9.93 86 413306 21989 64063351
Tooth abscess 12.65 9.93 140 413252 13686 64071654
Joint warmth 12.62 9.93 28 413364 1388 64083952
Arthropod bite 12.60 9.93 80 413312 6641 64078699
Antibody test positive 12.60 9.93 39 413353 2368 64082972
Abortion missed 12.57 9.93 25 413367 1147 64084193
Delusion 12.55 9.93 66 413326 17948 64067392
Device leakage 12.55 9.93 21 413371 8245 64077095
Rebound effect 12.55 9.93 8 413384 4909 64080431
Cholangitis 12.54 9.93 32 413360 10770 64074570
Heart rate irregular 12.50 9.93 246 413146 27167 64058173
Oesophageal fibrosis 12.46 9.93 10 413382 176 64085164
Pneumonia 12.46 9.93 3293 410099 556283 63529057
Haematemesis 12.42 9.93 219 413173 46780 64038560
Device dislocation 12.41 9.93 82 413310 21096 64064244
Hallucination, auditory 12.40 9.93 61 413331 16878 64068462
Hypertriglyceridaemia 12.39 9.93 34 413358 11171 64074169
Immune thrombocytopenia 12.38 9.93 52 413340 15014 64070326
Type 1 diabetes mellitus 12.35 9.93 11 413381 5694 64079646
Blood ethanol increased 12.34 9.93 18 413374 640 64084700
Chills 12.29 9.93 737 412655 136527 63948813
Sexual dysfunction 12.27 9.93 14 413378 6457 64078883
Epistaxis 12.26 9.93 509 412883 97622 63987718
Breast abscess 12.25 9.93 24 413368 1089 64084251
Paralysis 12.23 9.93 36 413356 11559 64073781
Bone marrow failure 12.18 9.93 225 413167 47727 64037613
Injection site haemorrhage 12.15 9.93 221 413171 24057 64061283
Vascular device infection 12.13 9.93 13 413379 6167 64079173
Delivery 12.12 9.93 16 413376 517 64084823
Adjustment disorder with depressed mood 12.12 9.93 39 413353 2418 64082922
Dry skin 12.10 9.93 243 413149 50918 64034422
Drug specific antibody 11.96 9.93 35 413357 2060 64083280
Opiates positive 11.94 9.93 21 413371 877 64084463
Muscle twitching 11.94 9.93 72 413320 18926 64066414
Catatonia 11.90 9.93 19 413373 7601 64077739
Hydrocephalus 11.79 9.93 19 413373 7572 64077768
Injection site discolouration 11.78 9.93 80 413312 6795 64078545
Skin laceration 11.78 9.93 221 413171 24196 64061144
Kidney infection 11.78 9.93 170 413222 17668 64067672
Toothache 11.77 9.93 167 413225 17292 64068048
C-reactive protein decreased 11.75 9.93 35 413357 2081 64083259
Angina unstable 11.73 9.93 55 413337 15412 64069928
Blood folate increased 11.72 9.93 15 413377 470 64084870
Stress at work 11.72 9.93 22 413370 967 64084373
Knee operation 11.69 9.93 59 413333 4498 64080842
Coronary artery bypass 11.67 9.93 12 413380 5803 64079537
Tendon disorder 11.64 9.93 75 413317 6257 64079083
Candida infection 11.61 9.93 137 413255 31282 64054058
Bradykinesia 11.59 9.93 15 413377 6545 64078795
Troponin increased 11.54 9.93 55 413337 15344 64069996
Hyperlipidaemia 11.52 9.93 93 413299 22883 64062457
Progressive multifocal leukoencephalopathy 11.51 9.93 69 413323 18163 64067177
Injection site extravasation 11.50 9.93 90 413302 7996 64077344
Skin ulcer haemorrhage 11.50 9.93 15 413377 479 64084861
Aphthous ulcer 11.49 9.93 130 413262 12776 64072564
Lymphopenia 11.47 9.93 107 413285 25550 64059790
Post procedural haemorrhage 11.44 9.93 41 413351 12390 64072950
Pancreatic steatosis 11.42 9.93 22 413370 986 64084354
Sciatica 11.41 9.93 188 413204 20076 64065264
Serum ferritin increased 11.36 9.93 93 413299 8375 64076965
Virologic failure 11.36 9.93 4 413388 3462 64081878
Vascular insufficiency 11.36 9.93 15 413377 485 64084855
Mean cell volume increased 11.35 9.93 63 413329 4983 64080357
Renal tubular disorder 11.30 9.93 13 413379 5974 64079366
Overdose 11.26 9.93 1178 412214 158388 63926952
Laryngospasm 11.25 9.93 4 413388 3441 64081899
Tooth disorder 11.23 9.93 204 413188 22198 64063142
Eyelid ptosis 11.23 9.93 28 413364 9497 64075843
Myofascial pain syndrome 11.20 9.93 31 413361 1767 64083573
Wound infection 11.18 9.93 145 413247 14719 64070621
Finger deformity 11.17 9.93 64 413328 5122 64080218
Maternal drugs affecting foetus 11.17 9.93 29 413363 1591 64083749
Complications of transplanted kidney 11.16 9.93 11 413381 5424 64079916
Postpartum haemorrhage 11.13 9.93 27 413365 1420 64083920
Retinitis 11.12 9.93 34 413358 2051 64083289
Acute lymphocytic leukaemia recurrent 11.05 9.93 6 413386 4020 64081320
Brain natriuretic peptide increased 11.03 9.93 20 413372 7613 64077727
Pericardial effusion 10.99 9.93 181 413211 39073 64046267
Osteoporotic fracture 10.99 9.93 49 413343 3549 64081791
Abortion incomplete 10.99 9.93 3 413389 3058 64082282
Foot operation 10.99 9.93 55 413337 4180 64081160
Oxygen consumption increased 10.96 9.93 8 413384 4573 64080767
Eye infection 10.92 9.93 99 413293 9182 64076158
Atrial flutter 10.88 9.93 76 413316 19304 64066036
Vacuum extractor delivery 10.87 9.93 8 413384 123 64085217
Skin neoplasm excision 10.86 9.93 20 413372 866 64084474
Haematocrit decreased 10.85 9.93 441 412951 54214 64031126
Myocardial ischaemia 10.81 9.93 96 413296 23155 64062185
Fine motor skill dysfunction 10.79 9.93 59 413333 4640 64080700
Cirrhosis alcoholic 10.78 9.93 21 413371 949 64084391
Skin graft failure 10.77 9.93 10 413382 216 64085124
Erectile dysfunction 10.74 9.93 43 413349 12584 64072756
Chemical submission 10.69 9.93 10 413382 218 64085122
Peritoneal dialysis complication 10.66 9.93 35 413357 2193 64083147
Drooling 10.65 9.93 11 413381 5308 64080032
Systemic inflammatory response syndrome 10.63 9.93 32 413360 10203 64075137
Mania 10.62 9.93 61 413331 16225 64069115
Mesothelioma 10.59 9.93 12 413380 330 64085010
Radiation inflammation 10.55 9.93 10 413382 222 64085118
Respiratory syncytial virus infection 10.55 9.93 19 413373 7249 64078091
Full blood count abnormal 10.52 9.93 131 413261 29626 64055714
Swollen joint count 10.50 9.93 16 413376 592 64084748
Capillary leak syndrome 10.47 9.93 4 413388 3293 64082047
Acute graft versus host disease in intestine 10.47 9.93 5 413387 3604 64081736
Type 2 diabetes mellitus 10.47 9.93 289 413103 33731 64051609
Osteonecrosis 10.47 9.93 123 413269 28106 64057234
Nail injury 10.45 9.93 14 413378 459 64084881
Chondropathy 10.44 9.93 36 413356 2313 64083027
Medical device site joint infection 10.44 9.93 10 413382 225 64085115
Macrocytosis 10.40 9.93 37 413355 2415 64082925
Intracranial pressure increased 10.39 9.93 18 413374 6971 64078369
Lip blister 10.37 9.93 35 413357 2224 64083116
Multiple-drug resistance 10.36 9.93 16 413376 6486 64078854
Lower gastrointestinal haemorrhage 10.32 9.93 50 413342 13889 64071451
Anti-neutrophil cytoplasmic antibody positive vasculitis 10.31 9.93 3 413389 2933 64082407
Pancreatic duct stenosis 10.29 9.93 10 413382 229 64085111
Plasmacytoma 10.29 9.93 6 413386 3864 64081476
Dermatitis bullous 10.28 9.93 41 413351 12013 64073327
Aplasia 10.25 9.93 18 413374 6935 64078405
Amphetamines positive 10.22 9.93 10 413382 231 64085109
Hernia 10.22 9.93 132 413260 13386 64071954
Failed induction of labour 10.19 9.93 10 413382 232 64085108
Benign ovarian tumour 10.17 9.93 11 413381 287 64085053
Anal fistula 10.14 9.93 63 413329 5190 64080150
Electrolyte imbalance 10.14 9.93 108 413284 25135 64060205
Motor dysfunction 10.14 9.93 38 413354 11335 64074005
Complication associated with device 10.09 9.93 56 413336 15024 64070316
Therapy change 10.09 9.93 16 413376 6418 64078922
Metastasis 10.08 9.93 13 413379 5682 64079658
Speech disorder developmental 10.06 9.93 15 413377 544 64084796
Pseudomembranous colitis 10.03 9.93 10 413382 4906 64080434
Alcoholic 9.99 9.93 5 413387 36 64085304
Physical assault 9.97 9.93 27 413365 1519 64083821
Drug tolerance 9.95 9.93 70 413322 6015 64079325
Haemorrhage subcutaneous 9.94 9.93 8 413384 4353 64080987

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000975 Antioxidants
MeSH PA D018977 Micronutrients
MeSH PA D020011 Protective Agents
MeSH PA D014815 Vitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017691 VUID
N0000179281 NUI
D01735 KEGG_DRUG
52225-20-4 SECONDARY_CAS_RN
7695-91-2 SECONDARY_CAS_RN
4017635 VANDF
4017691 VANDF
4017773 VANDF
4020803 VANDF
C1999896 UMLSCUI
CHEBI:32321 CHEBI
CHEMBL3989859 ChEMBL_ID
D024502 MESH_DESCRIPTOR_UI
DB14003 DRUGBANK_ID
86472 PUBCHEM_CID
DB14002 DRUGBANK_ID
DB11635 DRUGBANK_ID
1046243 RXNORM
7433 MMSL
001021 NDDF
007607 NDDF
009945 NDDF
395830006 SNOMEDCT_US
C0606070 UMLSCUI
CHEMBL1047 ChEMBL_ID
WR1WPI7EW8 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 11 [iU] ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 30 [iU] ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 30 [iU] ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 30 [iU] ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 30 [iU] ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 30 [iU] ORAL Unapproved drug other 11 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 30 [iU] ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 9 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 30 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 9 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 30 [iU] ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 30 [iU] ORAL UNAPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 30 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 22 mg ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 22 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 30 mg ORAL unapproved drug other 15 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 30 mg ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 30 [iU] ORAL unapproved drug other 16 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 15338-522 TABLET, FILM COATED 22 mg ORAL unapproved drug other 8 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 5 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 12 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 14 15370-102 LIQUID 5 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
TriStart DHA HUMAN PRESCRIPTION DRUG LABEL 15 15370-250 CAPSULE, LIQUID FILLED 15 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 17856-0668 TABLET, FILM COATED 22 mg ORAL UNAPPROVED DRUG OTHER 6 sections
SimmyungSaengMoSuHair tonic HUMAN OTC DRUG LABEL 3 32819-1001 LIQUID 3 mL TOPICAL unapproved drug other 8 sections
Prenatal Plus Vitamins HUMAN PRESCRIPTION DRUG LABEL 15 39328-106 TABLET 10 mg ORAL UNAPPROVED DRUG OTHER 7 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 18 42192-320 TABLET, FILM COATED 10 [iU] ORAL unapproved drug other 10 sections
PNV-DHA HUMAN PRESCRIPTION DRUG LABEL 10 42192-321 CAPSULE, GELATIN COATED 10 [iU] ORAL unapproved drug other 11 sections
PNV-DHA HUMAN PRESCRIPTION DRUG LABEL 8 42192-323 CAPSULE, GELATIN COATED 30 [iU] ORAL unapproved drug other 11 sections
Prenaissance Plus HUMAN PRESCRIPTION DRUG LABEL 8 42192-343 CAPSULE, LIQUID FILLED 30 [iU] ORAL UNAPPROVED DRUG OTHER 10 sections