oxedrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetics 3577 94-07-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • p-synephrine
  • oxedrine hydrochloride
  • oxedrine tartrate
  • analeptin
  • DL-Synephrine
  • oxedrine
  • parasympatol
  • simpatol
  • sympaethamin
  • sympaethamine
  • synthenate
  • synephrine
  • oxedrine HCl
Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.
  • Molecular weight: 167.21
  • Formula: C9H13NO2
  • CLOGP: -0.09
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 52.49
  • ALOGS: -0.95
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.20 g O
0.20 g P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01CA08 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Adrenergic and dopaminergic agents
ATC S01GA06 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Sympathomimetics used as decongestants
ATC S01GA56 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Sympathomimetics used as decongestants
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014663 Nasal Decongestants
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D013566 Sympathomimetics
MeSH PA D014662 Vasoconstrictor Agents
CHEBI has role CHEBI:35569 alpha-adrenergic agonists
CHEBI has role CHEBI:76924 plant metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Eustachian Tube Congestion indication
Priapism off-label use 6273006 DOID:9286
Low blood pressure off-label use 45007003
Myocardial infarction contraindication 22298006 DOID:5844
Ventricular tachycardia contraindication 25569003
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Acidosis contraindication 51387008
Heart disease contraindication 56265001 DOID:114
Arterial thrombosis contraindication 65198009
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Arterial aneurysm contraindication 233981004
Benign prostatic hyperplasia contraindication 266569009
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Disorder of coronary artery contraindication 414024009
Hypertensive urgency contraindication 443482000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.17 acidic
pKa2 9.11 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 1A GPCR Ki 4.20 CHEMBL
Neuromedin-U receptor 2 GPCR EC50 5.18 CHEMBL

External reference:

IDSource
PEG5DP7434 UNII
N0000166809 NUI
D07148 KEGG_DRUG
5985-28-4 SECONDARY_CAS_RN
16589-24-5 SECONDARY_CAS_RN
C0795712 UMLSCUI
CHEBI:29081 CHEBI
CHEMBL33720 ChEMBL_ID
7172 PUBCHEM_CID
DB09203 DRUGBANK_ID
D013578 MESH_DESCRIPTOR_UI
10288 RXNORM
005725 NDDF
419339003 SNOMEDCT_US
420192008 SNOMEDCT_US

Pharmaceutical products:

None