ornithine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3401 70-26-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ornithine
  • L-Ornithine
  • (S)-2,5-Diaminopentanoic acid
  • (S)-Ornithine
An amino acid produced in the urea cycle by the splitting off of urea from arginine.
  • Molecular weight: 132.16
  • Formula: C5H12N2O2
  • CLOGP: -2.85
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 89.34
  • ALOGS: 0.11
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:62868 hepatoprotective agents
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:84735 algal metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:83056 Daphnia magna metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Female Facial Hirsutism indication
Eruption of skin contraindication 271807003 DOID:0050486
Skin irritation contraindication 367466007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.85 acidic
pKa2 10.19 Basic
pKa3 9.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
G-protein coupled receptor family C group 6 member A GPCR AGONIST EC50 4 IUPHAR

External reference:

IDSource
N0000006781 NUI
D08302 KEGG_DRUG
4020565 VANDF
C0029277 UMLSCUI
CHEBI:18257 CHEBI
ORN PDB_CHEM_ID
CHEMBL446143 ChEMBL_ID
6262 PUBCHEM_CID
DB00129 DRUGBANK_ID
D009952 MESH_DESCRIPTOR_UI
6167 INN_ID
725 IUPHAR_LIGAND_ID
E524N2IXA3 UNII
314709 RXNORM
003541 NDDF
8514004 SNOMEDCT_US

Pharmaceutical products:

None