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hydroquinone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3282	123-31-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: 1,4-Benzenediol hydroquinone benzene-1,4-diol idrochinone	skin depigmentation agent Molecular weight: 110.11 Formula: C6H6O2 CLOGP: 0.81 LIPINSKI: 0 HAC: 2 HDO: 2 TPSA: 40.46 ALOGS: -0.06 ROTB: 0 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

1,4-Benzenediol
hydroquinone
benzene-1,4-diol
idrochinone

skin depigmentation agent

Molecular weight: 110.11
Formula: C6H6O2
CLOGP: 0.81
LIPINSKI: 0
HAC: 2
HDO: 2
TPSA: 40.46
ALOGS: -0.06
ROTB: 0

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Jan. 18, 2002	FDA	GALDERMA LABS LP

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Squamous cell carcinoma of skin	192.84	34.10	35	523	6097	63482367
Skin atrophy	109.40	34.10	21	537	4885	63483579
Neoplasm skin	83.18	34.10	14	544	1547	63486917
Ochronosis	61.21	34.10	7	551	40	63488424
Product use in unapproved indication	40.68	34.10	23	535	179057	63309407

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Squamous cell carcinoma of skin	176.95	39.20	35	450	13998	79729905
Skin atrophy	113.97	39.20	21	464	5697	79738206
Neoplasm skin	87.92	39.20	14	471	1597	79742306
Ochronosis	81.52	39.20	9	476	55	79743848
Product use in unapproved indication	41.45	39.20	23	462	250336	79493567

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D11AX11	DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals
MeSH PA	D000975	Antioxidants
MeSH PA	D009153	Mutagens
MeSH PA	D009676	Noxae
MeSH PA	D020011	Protective Agents
MeSH PA	D011837	Radiation-Protective Agents
FDA MoA	N0000175850	Melanin Synthesis Inhibitors
FDA PE	N0000175851	Depigmenting Activity
FDA EPC	N0000175854	Melanin Synthesis Inhibitor
CHEBI has role	CHEBI:22586	antioxidants
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:50903	carcinogen
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:76967	human xenobiotic metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:85046	skin lightening agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Discoloration of skin	indication	3253007
Chloasma	indication	36209000
Facial Hyperpigmentation	indication
Sunburn	contraindication	23346002
Eczema	contraindication	43116000
Telangiectasia disorder	contraindication	247479008
Pregnancy, function	contraindication	289908002
Adrenal cortical hypofunction	contraindication	386584007	DOID:10493
Atrophoderma	contraindication	399979006
Peripheral vascular disease	contraindication	400047006
Breastfeeding (mother)	contraindication	413712001
Denuded skin	contraindication	418242004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.26	acidic
pKa2	11.59	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN	Ki	7.05	CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN	Ki	4.97	CHEMBL
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN	Ki	4.97	CHEMBL
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN	Ki	4.49	CHEMBL
Carbonic anhydrase 12	Enzyme	O43570	CAH12_HUMAN	Ki	5.11	CHEMBL
Carbonic anhydrase 5A, mitochondrial	Enzyme	P35218	CAH5A_HUMAN	Ki	4.85	CHEMBL
Carbonic anhydrase 5B, mitochondrial	Enzyme	Q9Y2D0	CAH5B_HUMAN	Ki	4.90	CHEMBL
Carbonic anhydrase 3	Enzyme	P07451	CAH3_HUMAN	Ki	5.09	CHEMBL
Carbonic anhydrase 14	Enzyme	Q9ULX7	CAH14_HUMAN	Ki	4.38	CHEMBL
Carbonic anhydrase 13	Enzyme		CAH13_MOUSE	Ki	4.13	CHEMBL
Acetylcholinesterase	Enzyme		ACES_ELEEL	Ki	8.91	CHEMBL
Polyphenol oxidase 2	Enzyme		PPO2_AGABI	IC50	5.01	CHEMBL
Carbonic anhydrase 15	Enzyme		CAH15_MOUSE	Ki	4.97	CHEMBL
Carbonic anhydrase	Enzyme		Q2PCB5_DICLA	Ki	5.23	CHEMBL

External reference:

ID	Source
XV74C1N1AE	UNII
4018886	VUID
N0000147180	NUI
D00073	KEGG_DRUG
4018886	VANDF
C0020306	UMLSCUI
CHEBI:17594	CHEBI
HQE	PDB_CHEM_ID
CHEMBL537	ChEMBL_ID
785	PUBCHEM_CID
DB09526	DRUGBANK_ID
C031927	MESH_SUPPLEMENTAL_RECORD_UI
5509	RXNORM
1507	MMSL
4849	MMSL
002019	NDDF
387422001	SNOMEDCT_US
74583006	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Differin Dark Spot Correcting Serum	HUMAN OTC DRUG LABEL	1	0299-4608	SOLUTION	2 g	TOPICAL	OTC monograph not final	9 sections
TRI-LUMA	HUMAN PRESCRIPTION DRUG LABEL	3	0299-5950	CREAM	40 mg	TOPICAL	NDA	24 sections
TRI-LUMA	HUMAN PRESCRIPTION DRUG LABEL	3	0299-5950	CREAM	40 mg	TOPICAL	NDA	24 sections
TRI-LUMA	HUMAN PRESCRIPTION DRUG LABEL	3	0299-5950	CREAM	40 mg	TOPICAL	NDA	24 sections
hydroquinone	HUMAN PRESCRIPTION DRUG LABEL	1	10135-724	CREAM	40 mg	TOPICAL	unapproved drug other	19 sections
hydroquinone	HUMAN PRESCRIPTION DRUG LABEL	1	10135-724	CREAM	40 mg	TOPICAL	unapproved drug other	19 sections
Proactiv Advanced Dark Spot Correcting Serum	HUMAN OTC DRUG LABEL	1	11410-045	LIQUID	20 mg	TOPICAL	OTC MONOGRAPH NOT FINAL	13 sections
Proactiv Advanced Dark Spot Correcting Serum	HUMAN OTC DRUG LABEL	1	11410-045	LIQUID	20 mg	TOPICAL	OTC MONOGRAPH NOT FINAL	13 sections
Skin LighteningRodan Fields	HUMAN OTC DRUG LABEL	1	14222-1615	LIQUID	2 mL	TOPICAL	OTC monograph not final	8 sections
Skin Beautifying Milk	HUMAN OTC DRUG LABEL	1	16708-001	CREAM	0.02 g	TOPICAL	OTC monograph not final	11 sections
Medicated Fade Creme with Sunscreen	HUMAN OTC DRUG LABEL	2	16708-002	CREAM	0.02 g	TOPICAL	OTC monograph not final	10 sections
Advanced Lightning	HUMAN OTC DRUG LABEL	2	24623-042	CREAM	0.02 g	TOPICAL	OTC MONOGRAPH NOT FINAL	11 sections
Hydroquinone cream	HUMAN PRESCRIPTION DRUG LABEL	1	24689-101	CREAM	40 mg	TOPICAL	unapproved drug other	11 sections
Hydroquinone	HUMAN PRESCRIPTION DRUG LABEL	1	24979-141	CREAM	40 mg	TOPICAL	Unapproved drug other	21 sections
hydroquinone time release	HUMAN PRESCRIPTION DRUG LABEL	1	24979-144	CREAM	40 mg	TOPICAL	Unapproved drug other	21 sections
Hydro-Q	HUMAN PRESCRIPTION DRUG LABEL	1	30815-0040	GEL	40 mg	TOPICAL	UNAPPROVED DRUG OTHER	17 sections
Hydro-Q	HUMAN PRESCRIPTION DRUG LABEL	1	30815-0040	GEL	40 mg	TOPICAL	UNAPPROVED DRUG OTHER	17 sections
HYDROQUINONE 4%	HUMAN PRESCRIPTION DRUG LABEL	1	42192-151	CREAM	40 mg	TOPICAL	unapproved drug other	21 sections
Hydroquinone	HUMAN PRESCRIPTION DRUG LABEL	1	42582-700	CREAM	40 mg	TOPICAL	UNAPPROVED DRUG OTHER	22 sections
MELAMIN Skin Bleaching and Correcting	HUMAN PRESCRIPTION DRUG LABEL	1	42851-030	CREAM	0.04 g	TOPICAL	UNAPPROVED DRUG OTHER	9 sections
MELAMIX Skin Lightener and Blending	HUMAN PRESCRIPTION DRUG LABEL	1	42851-031	CREAM	0.04 g	TOPICAL	UNAPPROVED DRUG OTHER	13 sections
MELAMIN Skin Bleaching and Correcting Hydroquinone	HUMAN PRESCRIPTION DRUG LABEL	1	42851-032	CREAM	0.04 g	TOPICAL	UNAPPROVED DRUG OTHER	10 sections
MELAMIX Skin Lightener and Blending	HUMAN PRESCRIPTION DRUG LABEL	1	42851-033	CREAM	0.04 g	TOPICAL	UNAPPROVED DRUG OTHER	7 sections
ZO MEDICAL MELAMIN-C Skin Bleaching and Correcting with Vitamin C Hydroquinone	HUMAN PRESCRIPTION DRUG LABEL	1	42851-034	CREAM	0.04 g	TOPICAL	Export only	18 sections
ZO Skin Health Pigment Control plus Brightening Creme Hydroquinone plus Vitamin C	HUMAN PRESCRIPTION DRUG LABEL	1	42851-035	EMULSION	0.04 mg	TOPICAL	UNAPPROVED DRUG OTHER	5 sections
ZO Skin Health Pigment Control plus Brightening Creme Hydroquinone plus Vitamin C	HUMAN PRESCRIPTION DRUG LABEL	1	42851-035	EMULSION	0.04 mg	TOPICAL	UNAPPROVED DRUG OTHER	5 sections
ZO Skin Health Pigment Control plus Blending Creme Hydroquinone	HUMAN PRESCRIPTION DRUG LABEL	1	42851-036	EMULSION	0.04 g	TOPICAL	UNAPPROVED DRUG OTHER	5 sections
ZO Skin Health Pigment Control plus Blending Creme Hydroquinone	HUMAN PRESCRIPTION DRUG LABEL	1	42851-036	EMULSION	0.04 g	TOPICAL	UNAPPROVED DRUG OTHER	5 sections
ZO Skin Health Pigment Control Creme Hydroquinone	HUMAN PRESCRIPTION DRUG LABEL	1	42851-037	EMULSION	40 mg	TOPICAL	Unapproved drug other	5 sections
ZO Skin Health Pigment Control Creme Hydroquinone	HUMAN PRESCRIPTION DRUG LABEL	1	42851-037	EMULSION	40 mg	TOPICAL	Unapproved drug other	5 sections