ethacridine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
acridine derivatives 3194 442-16-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ethacridine
  • etakridin
  • ethacridine lactate
A topically applied anti-infective agent.
  • Molecular weight: 253.31
  • Formula: C15H15N3O
  • CLOGP: 3.37
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 74.16
  • ALOGS: -3.58
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B05CA08 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Antiinfectives
ATC D08AA01 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Acridine derivatives
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.96 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Telomerase reverse transcriptase Enzyme IC50 5.09 CHEMBL
Reverse transcriptase/RNaseH Enzyme IC50 4.70 CHEMBL
Reverse transcriptase Enzyme IC50 4.70 CHEMBL

External reference:

IDSource
N0000167269 NUI
D07924 KEGG_DRUG
6402-23-9 SECONDARY_CAS_RN
C0014960 UMLSCUI
CHEBI:135032 CHEBI
CHEMBL94007 ChEMBL_ID
DB13190 DRUGBANK_ID
CHEMBL2355915 ChEMBL_ID
CHEMBL582355 ChEMBL_ID
D004975 MESH_DESCRIPTOR_UI
2017 PUBCHEM_CID
1783 INN_ID
WIX85M1A6R UNII
4106 RXNORM
005540 NDDF
005541 NDDF
711320003 SNOMEDCT_US
715469007 SNOMEDCT_US

Pharmaceutical products:

None