desirudin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
hirudin derivatives 2990 120993-53-5

Description:

MoleculeDescription

Synonyms:

  • desirudin recombinant
  • desulfatohirudin
  • desulphatohirudin
  • IK-HIR02
  • desirudin
  • revasc
recombinant hirudin; has identical amino acid sequence as the natural hirudin variant 1 but lacks the sulphate group on Tyr(63)
  • Molecular weight: 6963.49
  • Formula: C287H440N80O110S6
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 3086.89
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
30 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 4, 2003 FDA MARATHON PHARMS LLC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AE01 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Direct thrombin inhibitors
FDA MoA N0000009963 Thrombin Inhibitors
FDA EPC N0000175518 Direct Thrombin Inhibitor
MeSH PA D000925 Anticoagulants
MeSH PA D002317 Cardiovascular Agents
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
FDA EPC N0000175980 Anti-coagulant
CHEBI has role CHEBI:50249 anticoagulants
CHEBI has role CHEBI:65232 thrombin inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Prevention of deep vein thrombosis indication 439993001
Intracranial hemorrhage contraindication 1386000
Diabetic retinopathy contraindication 4855003 DOID:8947
Retinal hemorrhage contraindication 28998008
Blood coagulation disorder contraindication 64779008 DOID:1247
Operation on brain contraindication 70586009
Gastrointestinal hemorrhage contraindication 74474003
Pulmonary hemorrhage contraindication 78144005
Hemophilia contraindication 90935002
Procedure on central nervous system contraindication 118679007
Impaired renal function disorder contraindication 197663003
Hemorrhagic cerebral infarction contraindication 230706003
Local anesthetic intrathecal block contraindication 231249005
Procedure on spine contraindication 238181003
Lumbar puncture contraindication 277762005
Bacterial endocarditis contraindication 301183007
Surgical procedure contraindication 387713003
Hypertensive urgency contraindication 443482000
Ocular Bleeding contraindication
Placement of Epidural Catheter contraindication
Significant Bleeding contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prothrombin Enzyme INHIBITOR Ki 12.70 IUPHAR DRUG LABEL

External reference:

IDSource
4032625 VUID
N0000188382 NUI
D03692 KEGG_DRUG
4032625 VANDF
C0378366 UMLSCUI
CHEBI:140427 CHEBI
CHEMBL1201662 ChEMBL_ID
DB11095 DRUGBANK_ID
C060225 MESH_SUPPLEMENTAL_RECORD_UI
6458 IUPHAR_LIGAND_ID
7193 INN_ID
U0JZ726775 UNII
16129703 PUBCHEM_CID
114934 RXNORM
17230 MMSL
d04865 MMSL
007722 NDDF
319718008 SNOMEDCT_US
407117009 SNOMEDCT_US

Pharmaceutical products:

None