belotecan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastics, topoisomerase I inhibitors 296 256411-32-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • belotecan
  • camtobell
  • belotecan hydrochloride
  • CKD602
  • CKD-602
  • Molecular weight: 433.51
  • Formula: C25H27N3O4
  • CLOGP: 1.47
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 91.76
  • ALOGS: -3.75
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 10, 2003 Korean Food and Drug Administration (KFDA) Chong Kun Dang

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01CE04 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Topoisomerase 1 (TOP1) inhibitors
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059004 Topoisomerase I Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Non-small cell lung cancer indication 254637007 DOID:3908
Malignant tumor of ovary indication 363443007 DOID:2394




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.72 acidic
pKa2 10.12 Basic
pKa3 2.85 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
DNA topoisomerase 1 Enzyme INHIBITOR IC50 6.56 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
C0762737 UMLSCUI
CHEBI:135702 CHEBI
D03225 KEGG_DRUG
CHEMBL2111084 ChEMBL_ID
DB12459 DRUGBANK_ID
C116963 MESH_SUPPLEMENTAL_RECORD_UI
6456014 PUBCHEM_CID
8483 INN_ID
213819-48-8 SECONDARY_CAS_RN
27Z82M2G1N UNII
CHEMBL2107315 ChEMBL_ID

Pharmaceutical products:

None