colecalciferol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 2840 67-97-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Vitamin D3
  • cholecalciferol
  • arachitol
  • calciol
  • calcirol
  • colecalciferol
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24. Some experts recommend maintaining recommended levels of vitamin D intake during the COVID-19 pandemic to maintain bone and muscle health and avoid deficiency. Efficacy of vitamin D supplementation in the prevention or treatment of COVID-19 has not been established.
  • Molecular weight: 384.65
  • Formula: C27H44O
  • CLOGP: 9.48
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -6.01
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mcg O
10 mg O
5 mg O
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.10 mg/mL Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
May 18, 2000 FDA SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1331.08 10.40 126 572236 145794 45967906
Toxicity to various agents 976.61 10.40 704 571658 211062 45902638
Femur fracture 562.58 10.40 1337 571025 35660 46078040
Drug abuse 546.58 10.40 67 572295 63341 46050359
Death 540.67 10.40 2199 570163 333349 45780351
Intentional overdose 449.52 10.40 120 572242 64824 46048876
Drug hypersensitivity 431.03 10.40 1538 570824 242287 45871413
Pemphigus 342.52 10.40 1277 571085 43997 46069703
Overdose 331.85 10.40 459 571903 101520 46012180
Low turnover osteopathy 330.60 10.40 331 572031 3958 46109742
Drug interaction 303.12 10.40 1369 570993 201725 45911975
Suicide attempt 286.14 10.40 159 572203 54877 46058823
Systemic lupus erythematosus 275.85 10.40 1549 570813 63631 46050069
Intramedullary rod insertion 273.83 10.40 220 572142 1923 46111777
Cardiac arrest 273.46 10.40 428 571934 89971 46023729
Rheumatoid arthritis 235.50 10.40 4195 568167 236020 45877680
Glossodynia 231.63 10.40 1118 571244 43255 46070445
Cardio-respiratory arrest 228.16 10.40 238 572124 59631 46054069
Arthralgia 211.69 10.40 5908 566454 358695 45755005
Alopecia 209.94 10.40 2971 569391 159443 45954257
Osteoarthritis 192.57 10.40 1362 571000 60663 46053037
Respiratory arrest 187.20 10.40 90 572272 33726 46079974
Fall 184.59 10.40 5310 567052 323787 45789913
Febrile neutropenia 179.02 10.40 579 571783 94048 46019652
Depressed level of consciousness 173.60 10.40 196 572166 47373 46066327
Coma 165.48 10.40 288 572074 58061 46055639
Open reduction of fracture 163.94 10.40 127 572235 1047 46112653
Arthropathy 162.71 10.40 1671 570691 83029 46030671
Device expulsion 162.36 10.40 67 572295 27475 46086225
Abdominal discomfort 154.02 10.40 2657 569705 148508 45965192
Osteoporosis 146.05 10.40 925 571437 39683 46074017
Hand deformity 141.82 10.40 815 571547 33759 46079941
Vitamin D deficiency 136.50 10.40 371 571991 10763 46102937
Fatigue 134.49 10.40 8913 563449 599784 45513916
Osteonecrosis of jaw 129.57 10.40 793 571569 33609 46080091
Hypotension 129.23 10.40 2039 570323 230550 45883150
Off label use 125.31 10.40 5773 566589 374068 45739632
Wound 123.12 10.40 923 571439 41879 46071821
Renal failure 117.87 10.40 861 571501 112733 46000967
Anaemia postoperative 113.84 10.40 137 572225 2039 46111661
Nasopharyngitis 112.52 10.40 2575 569787 151423 45962277
Tooth disorder 110.86 10.40 572 571790 22731 46090969
Pain 110.18 10.40 7012 565350 469936 45643764
Intentional self-injury 108.98 10.40 82 572280 24084 46089616
Stress fracture 106.59 10.40 256 572106 6871 46106829
Fracture nonunion 104.53 10.40 138 572224 2266 46111434
Agitation 103.43 10.40 341 572021 55074 46058626
Anaphylactic reaction 102.49 10.40 322 572040 52790 46060910
Product quality issue 101.93 10.40 175 572187 35473 46078227
Foot fracture 101.16 10.40 492 571870 19090 46094610
Multiple organ dysfunction syndrome 100.85 10.40 312 572050 51398 46062302
Maternal exposure during pregnancy 99.54 10.40 1789 570573 100760 46012940
Joint swelling 95.12 10.40 2688 569674 163385 45950315
Pain in extremity 94.96 10.40 3976 568386 254704 45858996
Drug reaction with eosinophilia and systemic symptoms 94.04 10.40 135 572227 29413 46084287
Knee arthroplasty 93.25 10.40 552 571810 23113 46090587
Poisoning 92.83 10.40 28 572334 13966 46099734
Impaired healing 91.76 10.40 767 571595 35976 46077724
Cardiac failure 91.32 10.40 589 571773 79359 46034341
Hepatic function abnormal 91.26 10.40 177 572185 34244 46079456
Drug dependence 90.42 10.40 67 572295 19834 46093866
Drug resistance 89.07 10.40 51 572311 17317 46096383
Myocardial infarction 88.75 10.40 766 571596 96762 46016938
Hepatic failure 88.45 10.40 172 572190 33244 46080456
Fracture delayed union 88.38 10.40 121 572241 2061 46111639
Cardiac failure congestive 87.84 10.40 711 571651 91039 46022661
Lactic acidosis 87.64 10.40 177 572185 33732 46079968
Metabolic acidosis 86.73 10.40 219 572143 38561 46075139
Hip arthroplasty 85.06 10.40 443 571919 17669 46096031
Malignant neoplasm progression 83.84 10.40 460 571902 64466 46049234
Osteopenia 83.24 10.40 420 571942 16541 46097159
Emotional distress 83.07 10.40 156 572206 30551 46083149
Bone density decreased 83.03 10.40 286 572076 9466 46104234
Spinal osteoarthritis 83.00 10.40 369 571993 13782 46099918
Drug withdrawal syndrome 81.48 10.40 131 572231 27253 46086447
Rebound effect 81.34 10.40 131 572231 2596 46111104
Cytomegalovirus infection 81.26 10.40 62 572300 18082 46095618
Serotonin syndrome 78.73 10.40 109 572253 24111 46089589
Atypical femur fracture 78.54 10.40 183 572179 4814 46108886
Somnolence 77.43 10.40 1401 570961 155120 45958580
Sedation 76.60 10.40 101 572261 22809 46090891
Basal cell carcinoma 76.35 10.40 471 571891 20016 46093684
Injury 74.09 10.40 283 572079 43744 46069956
Acute kidney injury 73.25 10.40 2267 570095 233588 45880112
Drug ineffective 73.23 10.40 7239 565123 670599 45443101
Thoracic vertebral fracture 72.74 10.40 157 572205 3918 46109782
Spinal fracture 72.33 10.40 375 571987 14930 46098770
Rhabdomyolysis 72.08 10.40 267 572095 41642 46072058
Disease progression 71.98 10.40 743 571619 90557 46023143
Shock 71.32 10.40 98 572264 21747 46091953
Respiratory failure 70.16 10.40 783 571579 94033 46019667
Dyspnoea 69.56 10.40 5411 566951 510137 45603563
Tachycardia 69.33 10.40 834 571528 98788 46014912
Mydriasis 68.41 10.40 22 572340 10531 46103169
Fracture 68.01 10.40 389 571973 16082 46097618
Lumbar vertebral fracture 67.77 10.40 163 572199 4379 46109321
Respiratory depression 67.11 10.40 29 572333 11571 46102129
Bradycardia 65.65 10.40 509 571853 65789 46047911
Seizure 65.49 10.40 1087 571275 121967 45991733
Vomiting 64.41 10.40 4731 567631 448063 45665637
Sinusitis 63.92 10.40 2062 570300 127706 45985994
Infusion related reaction 63.25 10.40 1657 570705 99551 46014149
Injection site reaction 62.77 10.40 878 571484 46971 46066729
Intervertebral disc degeneration 62.14 10.40 324 572038 12928 46100772
Musculoskeletal stiffness 62.00 10.40 1607 570755 96386 46017314
Loss of consciousness 61.30 10.40 945 571417 107293 46006407
Body height decreased 59.13 10.40 255 572107 9397 46104303
Electrocardiogram QT prolonged 58.66 10.40 378 571984 50947 46062753
Tooth fracture 58.65 10.40 250 572112 9165 46104535
Arthritis 58.65 10.40 1300 571062 76016 46037684
Anti-cyclic citrullinated peptide antibody positive 58.56 10.40 419 571943 18726 46094974
Encephalopathy 58.41 10.40 213 572149 33376 46080324
No adverse event 58.27 10.40 219 572143 34012 46079688
Sickle cell anaemia with crisis 58.21 10.40 142 572220 3850 46109850
Red blood cell sedimentation rate abnormal 58.10 10.40 325 572037 13324 46100376
Mental status changes 57.73 10.40 255 572107 37833 46075867
Neuroleptic malignant syndrome 56.54 10.40 33 572329 11089 46102611
Blood creatine phosphokinase increased 56.40 10.40 164 572198 27560 46086140
Peripheral swelling 56.18 10.40 2422 569940 155649 45958051
Joint effusion 56.06 10.40 293 572069 11702 46101998
Neutropenia 54.86 10.40 1336 571026 141868 45971832
Bone loss 54.49 10.40 109 572253 2574 46111126
Product use in unapproved indication 54.28 10.40 779 571583 89494 46024206
Anaphylactic shock 53.96 10.40 104 572258 20170 46093530
Torsade de pointes 53.83 10.40 42 572320 12112 46101588
Ventricular tachycardia 53.52 10.40 78 572284 16889 46096811
Injection site pruritus 52.83 10.40 731 571631 39012 46074688
Scoliosis 52.76 10.40 182 572180 6028 46107672
Urinary tract infection 51.45 10.40 3243 569119 217023 45896677
Intentional product misuse 50.89 10.40 353 572009 46775 46066925
Injection site erythema 50.76 10.40 1233 571129 73194 46040506
Pericarditis 50.74 10.40 482 571880 23445 46090255
Anhedonia 50.68 10.40 32 572330 10303 46103397
Aspartate aminotransferase increased 50.58 10.40 670 571692 78030 46035670
Medical device removal 49.95 10.40 70 572292 1220 46112480
Sopor 49.13 10.40 106 572256 19722 46093978
Altered state of consciousness 49.05 10.40 136 572226 23212 46090488
Ventricular fibrillation 48.10 10.40 42 572320 11454 46102246
Psychotic disorder 48.10 10.40 131 572231 22490 46091210
Hypoglycaemia 48.03 10.40 430 571932 53919 46059781
Bone marrow failure 47.19 10.40 195 572167 29474 46084226
Back pain 46.96 10.40 3081 569281 206958 45906742
Asthma 46.94 10.40 814 571548 90728 46022972
Product complaint 46.20 10.40 48 572314 12053 46101647
Hyperlipidaemia 45.75 10.40 386 571976 18153 46095547
Posterior reversible encephalopathy syndrome 45.45 10.40 72 572290 15069 46098631
Rheumatoid factor positive 45.30 10.40 416 571946 20045 46093655
Hypocalcaemia 45.16 10.40 515 571847 26270 46087430
Product use issue 44.55 10.40 1496 570866 93148 46020552
Neurotoxicity 44.31 10.40 62 572300 13655 46100045
Multiple sclerosis relapse 44.10 10.40 744 571618 41381 46072319
Cardiogenic shock 43.64 10.40 84 572278 16300 46097400
Injection site swelling 43.60 10.40 716 571646 39611 46074089
Alanine aminotransferase increased 43.30 10.40 793 571569 87658 46026042
Oropharyngeal pain 42.26 10.40 1200 571162 72968 46040732
Akathisia 41.98 10.40 21 572341 7693 46106007
Accidental exposure to product 41.94 10.40 126 572236 20955 46092745
Suicidal ideation 41.93 10.40 465 571897 55917 46057783
Pulmonary arterial hypertension 41.50 10.40 170 572192 25758 46087942
Vitamin D decreased 41.26 10.40 199 572163 7694 46106006
Aggression 41.03 10.40 142 572220 22602 46091098
Ascites 41.01 10.40 271 572091 36313 46077387
Pyrexia 40.99 10.40 3700 568662 345102 45768598
Thrombocytopenia 40.87 10.40 1210 571152 125371 45988329
Cerebrovascular accident 40.80 10.40 935 571427 100104 46013596
Influenza 40.74 10.40 1406 570956 87864 46025836
Venoocclusive liver disease 40.55 10.40 3 572359 4248 46109452
Synovial cyst 40.43 10.40 188 572174 7158 46106542
Spinal compression fracture 40.40 10.40 284 572078 12619 46101081
Coagulopathy 40.18 10.40 106 572256 18393 46095307
Bone graft 39.88 10.40 52 572310 843 46112857
Hyperkalaemia 39.81 10.40 413 571949 50296 46063404
Hypoxia 39.56 10.40 425 571937 51413 46062287
Ejection fraction decreased 39.56 10.40 102 572260 17835 46095865
Blood bilirubin increased 39.44 10.40 251 572111 33933 46079767
Musculoskeletal pain 39.23 10.40 1132 571230 68996 46044704
Transplant rejection 39.02 10.40 36 572326 9560 46104140
Psoriasis 38.93 10.40 1250 571112 77354 46036346
Unresponsive to stimuli 38.81 10.40 233 572129 31941 46081759
Disseminated intravascular coagulation 38.24 10.40 113 572249 18892 46094808
Product dose omission issue 38.19 10.40 2475 569887 166045 45947655
Skin cancer 38.16 10.40 211 572151 8612 46105088
Hypercholesterolaemia 38.00 10.40 257 572105 11273 46102427
Foot deformity 37.97 10.40 321 572041 15104 46098596
Lower respiratory tract infection 37.97 10.40 914 571448 54175 46059525
Acute hepatic failure 37.90 10.40 77 572285 14644 46099056
Septic shock 37.88 10.40 491 571871 57402 46056298
Infective pulmonary exacerbation of cystic fibrosis 37.50 10.40 244 572118 10563 46103137
Cataract 37.45 10.40 773 571589 44642 46069058
Graft versus host disease 37.28 10.40 17 572345 6571 46107129
Gastrooesophageal reflux disease 37.27 10.40 1184 571178 73160 46040540
Unintentional medical device removal 36.44 10.40 6 572356 4547 46109153
Renal injury 36.25 10.40 38 572324 9503 46104197
Bursitis 35.96 10.40 387 571975 19455 46094245
Cholecystitis chronic 35.39 10.40 46 572316 10453 46103247
Wrist fracture 35.32 10.40 252 572110 11251 46102449
Hyperglycaemia 35.30 10.40 268 572094 34803 46078897
Discomfort 35.15 10.40 784 571578 45886 46067814
Psoriatic arthropathy 35.03 10.40 634 571728 35745 46077955
Brain oedema 34.99 10.40 62 572300 12416 46101284
Swelling 34.93 10.40 1864 570498 122647 45991053
Contusion 34.83 10.40 1357 571005 86130 46027570
Renal impairment 34.78 10.40 672 571690 73700 46040000
Calcium deficiency 34.74 10.40 48 572314 825 46112875
Pulmonary oedema 34.71 10.40 430 571932 50675 46063025
Palmar-plantar erythrodysaesthesia syndrome 34.70 10.40 131 572231 20320 46093380
Hypomania 34.64 10.40 6 572356 4382 46109318
Substance abuse 34.47 10.40 5 572357 4162 46109538
Status epilepticus 34.41 10.40 75 572287 13904 46099796
Accidental overdose 34.39 10.40 128 572234 19938 46093762
Hepatotoxicity 34.05 10.40 174 572188 24835 46088865
Removal of internal fixation 33.93 10.40 18 572344 69 46113631
Dental implantation 33.78 10.40 39 572323 554 46113146
Acute respiratory distress syndrome 33.68 10.40 146 572216 21776 46091924
Haemodialysis 33.59 10.40 38 572324 9179 46104521
Cystitis 33.54 10.40 715 571647 41526 46072174
Post transplant lymphoproliferative disorder 33.40 10.40 4 572358 3852 46109848
Cerebral infarction 33.29 10.40 160 572202 23206 46090494
Wrong technique in product usage process 33.27 10.40 468 571894 53954 46059746
Abnormal behaviour 33.12 10.40 139 572223 20919 46092781
Dental caries 32.82 10.40 229 572133 10150 46103550
Bone disorder 32.80 10.40 383 571979 19650 46094050
Thrombotic microangiopathy 32.79 10.40 32 572330 8274 46105426
Blood pressure decreased 32.70 10.40 498 571864 56661 46057039
Drug level increased 32.69 10.40 116 572246 18325 46095375
Respiratory distress 32.55 10.40 243 572119 31673 46082027
Acute myeloid leukaemia 32.34 10.40 93 572269 15685 46098015
Lower respiratory tract infection viral 32.25 10.40 36 572326 492 46113208
Device use error 32.22 10.40 11 572351 5070 46108630
Bone density abnormal 32.20 10.40 97 572265 2987 46110713
International normalised ratio increased 31.64 10.40 395 571967 46488 46067212
Metastases to liver 31.60 10.40 128 572234 19457 46094243
Extrapyramidal disorder 31.59 10.40 56 572306 11212 46102488
Neck deformity 31.47 10.40 70 572292 1784 46111916
Injection site pain 31.44 10.40 1611 570751 105541 46008159
Blood pressure fluctuation 31.23 10.40 536 571826 29912 46083788
Muscle strain 31.11 10.40 166 572196 6683 46107017
Tibia fracture 30.96 10.40 123 572239 4366 46109334
Periprosthetic fracture 30.73 10.40 32 572330 402 46113298
Angioedema 30.64 10.40 321 572041 39021 46074679
Hallucination, auditory 30.56 10.40 53 572309 10703 46102997
Oedema 30.16 10.40 610 571752 66461 46047239
Disability assessment scale score increased 30.03 10.40 77 572285 2155 46111545
Carpal tunnel syndrome 30.00 10.40 312 572050 15547 46098153
Synovitis 29.91 10.40 970 571392 60105 46053595
Endodontic procedure 29.66 10.40 82 572280 2403 46111297
Pancreatitis 29.66 10.40 367 571995 43260 46070440
Stevens-Johnson syndrome 29.55 10.40 166 572196 23131 46090569
Kyphosis 29.54 10.40 78 572284 2223 46111477
Humerus fracture 29.54 10.40 176 572186 7386 46106314
Nausea 29.39 10.40 7739 564623 679715 45433985
Pulmonary embolism 29.11 10.40 1063 571299 107522 46006178
Malignant melanoma 29.02 10.40 220 572142 10014 46103686
Drug abuser 28.89 10.40 3 572359 3230 46110470
Multiple fractures 28.84 10.40 140 572222 5427 46108273
Blood cholesterol increased 28.83 10.40 668 571694 39345 46074355
Tonsillar ulcer 28.78 10.40 25 572337 246 46113454
Acute graft versus host disease 28.73 10.40 7 572355 4023 46109677
Dry eye 28.69 10.40 527 571835 29795 46083905
Cyanosis 28.62 10.40 100 572262 15871 46097829
Tonsillectomy 28.38 10.40 42 572320 771 46112929
Bronchospasm 28.38 10.40 98 572264 15609 46098091
Injection site bruising 28.22 10.40 603 571759 35033 46078667
Fibula fracture 28.15 10.40 91 572271 2913 46110787
Blood alkaline phosphatase increased 28.14 10.40 330 572032 39279 46074421
Osteoporotic fracture 28.13 10.40 91 572271 2914 46110786
Toxic epidermal necrolysis 28.11 10.40 159 572203 22119 46091581
Device difficult to use 28.09 10.40 34 572328 7970 46105730
Syncope 28.09 10.40 1026 571336 103777 46009923
Myoclonus 27.69 10.40 87 572275 14265 46099435
Exostosis 27.65 10.40 218 572144 10045 46103655
Lumbar spinal stenosis 27.61 10.40 117 572245 4278 46109422
Hypercalcaemia 27.52 10.40 386 571976 20660 46093040
Sepsis 27.38 10.40 1375 570987 134639 45979061
Rib fracture 26.98 10.40 353 572009 18601 46095099
C-reactive protein abnormal 26.96 10.40 388 571974 20882 46092818
Coronary artery disease 26.86 10.40 274 572088 33478 46080222
Asphyxia 26.80 10.40 16 572346 5310 46108390
Pathogen resistance 26.76 10.40 21 572341 6039 46107661
Restlessness 26.66 10.40 193 572169 25331 46088369
Fear 26.53 10.40 105 572257 16067 46097633
Pregnancy with contraceptive device 26.46 10.40 11 572351 4492 46109208
Dysarthria 26.42 10.40 313 572049 37185 46076515
Confusional state 26.39 10.40 1648 570714 158244 45955456
Intervertebral disc protrusion 26.18 10.40 373 571989 20032 46093668
Full blood count decreased 26.14 10.40 400 571962 21811 46091889
Bronchitis 26.11 10.40 1568 570794 104411 46009289
Weight decreased 26.10 10.40 2960 569402 207889 45905811
Polyarthritis 26.03 10.40 153 572209 6389 46107311
Spondylolisthesis 25.97 10.40 90 572272 2988 46110712
Patellofemoral pain syndrome 25.81 10.40 32 572330 492 46113208
Hypercalciuria 25.52 10.40 20 572342 168 46113532
Drug screen positive 25.42 10.40 8 572354 3883 46109817
Bone giant cell tumour 25.40 10.40 14 572348 59 46113641
Joint injury 25.39 10.40 353 572009 18856 46094844
Recalled product 25.39 10.40 50 572312 1167 46112533
Febrile bone marrow aplasia 25.33 10.40 28 572334 6834 46106866
Pleural effusion 25.28 10.40 799 571563 82153 46031547
Tendonitis 25.20 10.40 277 572085 14000 46099700
Blood glucose increased 25.11 10.40 681 571681 71332 46042368
Upper limb fracture 25.10 10.40 299 572063 15414 46098286
Transplant dysfunction 25.10 10.40 13 572349 4669 46109031
Urticaria 25.06 10.40 1185 571177 116707 45996993
Joint laxity 24.85 10.40 69 572293 2027 46111673
Haematotoxicity 24.82 10.40 29 572333 6904 46106796
Internal fixation of fracture 24.81 10.40 38 572324 720 46112980
Pregnancy 24.76 10.40 469 571893 26668 46087032
Developmental hip dysplasia 24.72 10.40 51 572311 1232 46112468
Cytomegalovirus viraemia 24.65 10.40 12 572350 4466 46109234
Face oedema 24.55 10.40 136 572226 19017 46094683
Oral herpes 24.30 10.40 353 572009 19037 46094663
Pelvic fracture 24.24 10.40 232 572130 11307 46102393
Device dislocation 24.18 10.40 162 572200 21640 46092060
Gingival disorder 24.14 10.40 91 572271 3150 46110550
Sciatica 24.13 10.40 347 572015 18673 46095027
Bone metabolism disorder 24.08 10.40 25 572337 313 46113387
Limb asymmetry 24.03 10.40 39 572323 778 46112922
Femoral neck fracture 24.01 10.40 176 572186 7927 46105773
Blood creatinine increased 23.99 10.40 733 571629 75670 46038030
Disorientation 23.82 10.40 314 572048 36604 46077096
Localised infection 23.69 10.40 417 571945 23384 46090316
Gastrointestinal haemorrhage 23.64 10.40 745 571617 76628 46037072
Injection site rash 23.57 10.40 297 572065 15516 46098184
Exposure during pregnancy 23.54 10.40 1584 570778 106628 46007072
Aspergillus infection 23.42 10.40 30 572332 6860 46106840
Hysterectomy 23.38 10.40 170 572192 7636 46106064
Uterine perforation 23.32 10.40 33 572329 7234 46106466
Disease recurrence 23.22 10.40 132 572230 18339 46095361
Bronchopulmonary aspergillosis 23.12 10.40 35 572327 7461 46106239
Genital haemorrhage 22.93 10.40 28 572334 6538 46107162
Rotator cuff syndrome 22.92 10.40 230 572132 11353 46102347
Tooth infection 22.90 10.40 241 572121 12045 46101655
Abortion incomplete 22.63 10.40 6 572356 3258 46110442
Dystonia 22.60 10.40 67 572295 11190 46102510
Night sweats 22.52 10.40 464 571898 26786 46086914
Tardive dyskinesia 22.52 10.40 36 572326 7507 46106193
Invasive ductal breast carcinoma 22.47 10.40 141 572221 6027 46107673
Muscle spasms 22.34 10.40 1776 570586 121337 45992363
Angina pectoris 22.29 10.40 215 572147 26560 46087140
BK virus infection 22.26 10.40 4 572358 2845 46110855
Oral infection 22.19 10.40 105 572257 4027 46109673
Increased tendency to bruise 22.19 10.40 195 572167 9279 46104421
Tremor 22.13 10.40 1175 571187 114464 45999236
Cataract operation 21.85 10.40 104 572258 3999 46109701
Meniscus injury 21.80 10.40 137 572225 5859 46107841
Radius fracture 21.80 10.40 90 572272 3252 46110448
Helicobacter infection 21.78 10.40 230 572132 11506 46102194
Ankle fracture 21.72 10.40 288 572074 15223 46098477
Intraductal proliferative breast lesion 21.54 10.40 76 572286 2546 46111154
Talipes 21.54 10.40 51 572311 1356 46112344
Squamous cell carcinoma 21.41 10.40 167 572195 7669 46106031
Graft versus host disease in gastrointestinal tract 21.23 10.40 3 572359 2547 46111153
Metastases to lung 21.23 10.40 64 572298 10632 46103068
Cardiotoxicity 21.10 10.40 31 572331 6691 46107009
Delirium 21.07 10.40 325 572037 36903 46076797
Irritability 21.02 10.40 240 572122 28706 46084994
Duodenal ulcer perforation 20.96 10.40 177 572185 8325 46105375
Haemorrhage 20.96 10.40 512 571850 54357 46059343
Chronic graft versus host disease 20.92 10.40 4 572358 2721 46110979
Atrophic vulvovaginitis 20.85 10.40 53 572309 1475 46112225
Limb reduction defect 20.79 10.40 24 572338 341 46113359
Mania 20.74 10.40 66 572296 10780 46102920
Hypothermia 20.69 10.40 78 572284 12105 46101595
Surgery 20.56 10.40 480 571882 28305 46085395
Platelet count decreased 20.54 10.40 1009 571353 99015 46014685
Hyperhidrosis 20.53 10.40 890 571472 88418 46025282
Jaundice 20.23 10.40 241 572121 28604 46085096
Skin papilloma 20.20 10.40 103 572259 4073 46109627
Limb injury 20.19 10.40 339 572023 18835 46094865
Appendicectomy 20.13 10.40 72 572290 2429 46111271
Gamma-glutamyltransferase increased 20.10 10.40 271 572091 31469 46082231
Toxic skin eruption 19.96 10.40 81 572281 12306 46101394
Anaemia 19.91 10.40 2790 569572 252989 45860711
Smear cervix abnormal 19.88 10.40 72 572290 2444 46111256
Inappropriate antidiuretic hormone secretion 19.83 10.40 97 572265 14005 46099695
Hepatocellular injury 19.82 10.40 249 572113 29273 46084427
Metastases to bone 19.81 10.40 129 572233 17347 46096353
Gestational diabetes 19.81 10.40 154 572208 7065 46106635
Device failure 19.74 10.40 133 572229 5826 46107874
Cellulitis 19.65 10.40 1052 571310 69236 46044464
Fluid overload 19.50 10.40 226 572136 26959 46086741
Muscle rigidity 19.48 10.40 60 572302 9901 46103799
Weight increased 19.40 10.40 2302 570060 162171 45951529
Wheezing 19.36 10.40 502 571860 52884 46060816
Dermatitis exfoliative 19.31 10.40 25 572337 5691 46108009
Myopathy 19.20 10.40 51 572311 8830 46104870
Obstructive airways disorder 19.01 10.40 92 572270 13320 46100380
Acute myocardial infarction 18.99 10.40 276 572086 31648 46082052
Angina unstable 18.99 10.40 40 572322 7508 46106192
Deep vein thrombosis 18.96 10.40 792 571570 78981 46034719
Anuria 18.89 10.40 74 572288 11357 46102343
Acute generalised exanthematous pustulosis 18.86 10.40 56 572306 9349 46104351
Musculoskeletal discomfort 18.86 10.40 259 572103 13797 46099903
Toothache 18.83 10.40 297 572065 16295 46097405
Respiratory acidosis 18.68 10.40 29 572333 6119 46107581
Cardiomyopathy 18.55 10.40 118 572244 15955 46097745
Incorrect route of product administration 18.54 10.40 121 572241 16262 46097438
Electrocardiogram QRS complex prolonged 18.24 10.40 24 572338 5425 46108275
Dysmorphism 18.08 10.40 58 572304 1849 46111851
Ligament sprain 18.07 10.40 203 572159 10316 46103384
Synovial disorder 18.06 10.40 35 572327 807 46112893
Ligament rupture 18.04 10.40 72 572290 2561 46111139
Hyperaesthesia teeth 18.03 10.40 51 572311 1515 46112185
Juvenile idiopathic arthritis 17.99 10.40 99 572263 4033 46109667
Haemophagocytic lymphohistiocytosis 17.97 10.40 48 572314 8294 46105406
Essential hypertension 17.93 10.40 102 572260 4208 46109492
Lumbar radiculopathy 17.92 10.40 56 572306 1760 46111940
Cyst 17.92 10.40 227 572135 11873 46101827
Contraindicated product administered 17.87 10.40 1173 571189 78774 46034926
Hypervitaminosis D 17.86 10.40 12 572350 77 46113623
Ileus paralytic 17.84 10.40 16 572346 4307 46109393
Pulmonary hypertension 17.82 10.40 322 572040 35671 46078029
Milk-alkali syndrome 17.82 10.40 29 572333 580 46113120
Small for dates baby 17.80 10.40 90 572272 3547 46110153
Periodontal disease 17.79 10.40 53 572309 1622 46112078
Cyst removal 17.72 10.40 23 572339 371 46113329
Metastases to central nervous system 17.69 10.40 74 572288 11147 46102553
Oliguria 17.68 10.40 52 572310 8707 46104993
Hypoacusis 17.64 10.40 358 572004 20611 46093089
Wrong product administered 17.64 10.40 26 572336 5604 46108096
Hyperbilirubinaemia 17.62 10.40 67 572295 10371 46103329
Sinus tachycardia 17.53 10.40 175 572187 21474 46092226
Mouth ulceration 17.53 10.40 442 571920 26390 46087310
Gastroenteritis viral 17.52 10.40 316 572046 17803 46095897
Hip fracture 17.51 10.40 438 571924 26118 46087582
Adenoidal disorder 17.50 10.40 12 572350 80 46113620
Hyperprolactinaemia 17.49 10.40 7 572355 2925 46110775
Anxiety 17.47 10.40 1958 570404 179999 45933701
Pulse absent 17.45 10.40 21 572341 4935 46108765
Gait spastic 17.42 10.40 18 572344 224 46113476
Pulmonary congestion 17.41 10.40 108 572254 14691 46099009
Colitis ulcerative 17.41 10.40 310 572052 17422 46096278
Diabetes mellitus inadequate control 17.39 10.40 93 572269 13121 46100579
Rash maculo-papular 17.28 10.40 239 572123 27635 46086065
Adenotonsillectomy 17.09 10.40 11 572351 65 46113635
Myocarditis 17.07 10.40 44 572318 7695 46106005
Catheter site pain 17.05 10.40 13 572349 3793 46109907
Cerebral haemorrhage 16.98 10.40 245 572117 28126 46085574
Neutrophil count decreased 16.92 10.40 404 571958 43022 46070678
Proteinuria 16.89 10.40 126 572236 16427 46097273
Arthritis infective 16.87 10.40 114 572248 4999 46108701
Mitral valve prolapse 16.83 10.40 64 572298 2225 46111475
Ear infection 16.82 10.40 385 571977 22628 46091072
Catatonia 16.66 10.40 13 572349 3749 46109951
Bladder operation 16.59 10.40 33 572329 776 46112924
Forced expiratory volume decreased 16.56 10.40 23 572339 5081 46108619
Bone pain 16.52 10.40 718 571644 46172 46067528
Diverticulitis 16.50 10.40 526 571836 32513 46081187
Schizophrenia 16.48 10.40 52 572310 8516 46105184
Agranulocytosis 16.48 10.40 183 572179 22002 46091698
Cold type haemolytic anaemia 16.46 10.40 16 572346 184 46113516
Nephrolithiasis 16.46 10.40 526 571836 32525 46081175
Anaemia of chronic disease 16.44 10.40 57 572305 1893 46111807
Joint noise 16.40 10.40 80 572282 3107 46110593
Anger 16.39 10.40 82 572280 11770 46101930
Pulseless electrical activity 16.39 10.40 40 572322 7127 46106573
Frequent bowel movements 16.24 10.40 231 572131 12401 46101299
Drug eruption 16.22 10.40 175 572187 21154 46092546
Miosis 16.15 10.40 36 572326 6621 46107079
Upper respiratory tract infection 16.15 10.40 943 571419 62613 46051087
Catheter site erythema 16.13 10.40 15 572347 3968 46109732
Alcohol interaction 16.02 10.40 5 572357 2440 46111260
Blood loss anaemia 16.02 10.40 168 572194 8389 46105311
Abortion spontaneous 15.98 10.40 671 571691 42975 46070725
Tonsillitis 15.97 10.40 110 572252 4854 46108846
Blood iron increased 15.96 10.40 44 572318 1287 46112413
Generalised oedema 15.96 10.40 107 572255 14292 46099408
Herpes zoster 15.93 10.40 1000 571362 66872 46046828
Erythema multiforme 15.92 10.40 63 572299 9641 46104059
Fibrocystic breast disease 15.89 10.40 41 572321 1152 46112548
Edentulous 15.85 10.40 18 572344 251 46113449
Blood parathyroid hormone increased 15.84 10.40 76 572286 2932 46110768
Gingival recession 15.83 10.40 43 572319 1247 46112453
Temporomandibular joint syndrome 15.80 10.40 85 572277 3433 46110267
Limb deformity 15.79 10.40 86 572276 3490 46110210
Loose tooth 15.68 10.40 80 572282 3164 46110536
Electrocardiogram PR shortened 15.67 10.40 15 572347 169 46113531
Scapula fracture 15.63 10.40 22 572340 385 46113315
Osteopetrosis 15.62 10.40 8 572354 28 46113672
Parathyroid tumour benign 15.59 10.40 28 572334 608 46113092
Drug use disorder 15.57 10.40 7 572355 2728 46110972
Hyperlactacidaemia 15.50 10.40 4 572358 2211 46111489
Cholestasis 15.48 10.40 234 572128 26659 46087041
Micturition frequency decreased 15.40 10.40 25 572337 499 46113201
Myelosuppression 15.35 10.40 46 572316 7657 46106043
Pathological fracture 15.32 10.40 157 572205 7793 46105907
Tumour lysis syndrome 15.31 10.40 42 572320 7194 46106506
Fracture displacement 15.29 10.40 42 572320 1226 46112474
Plantar fasciitis 15.15 10.40 70 572292 2658 46111042
Arthroscopy 15.13 10.40 29 572333 663 46113037
Post procedural hypothyroidism 15.12 10.40 13 572349 126 46113574
Neck mass 15.09 10.40 80 572282 3213 46110487
Tooth extraction 15.00 10.40 191 572171 10002 46103698
Nephrogenic systemic fibrosis 14.99 10.40 22 572340 4750 46108950
Adenovirus infection 14.96 10.40 8 572354 2822 46110878
Jaw disorder 14.95 10.40 111 572251 5019 46108681
Tooth loss 14.94 10.40 136 572226 6537 46107163
Bradyphrenia 14.86 10.40 34 572328 6196 46107504
Caesarean section 14.82 10.40 286 572076 16317 46097383
Rotator cuff repair 14.81 10.40 46 572316 1441 46112259
Hyperparathyroidism 14.81 10.40 65 572297 2414 46111286
Hepatitis fulminant 14.76 10.40 12 572350 3390 46110310
Tachypnoea 14.76 10.40 109 572253 14242 46099458
Breast conserving surgery 14.72 10.40 31 572331 760 46112940
Abscess oral 14.72 10.40 45 572317 1397 46112303
Prothrombin time prolonged 14.69 10.40 64 572298 9532 46104168
Latent tuberculosis 14.57 10.40 55 572307 1905 46111795
Dysphoria 14.57 10.40 21 572341 4568 46109132
Ventricular septal defect 14.56 10.40 92 572270 3942 46109758
Hyperammonaemia 14.56 10.40 22 572340 4694 46109006
Prescribed underdose 14.54 10.40 218 572144 11835 46101865
Live birth 14.54 10.40 192 572170 10138 46103562
Limb discomfort 14.53 10.40 374 571988 22402 46091298
Blood pH decreased 14.52 10.40 7 572355 2620 46111080
Interstitial lung disease 14.48 10.40 528 571834 53421 46060279
Hyperthermia 14.48 10.40 50 572312 7964 46105736
Biopsy breast 14.41 10.40 18 572344 279 46113421
Treatment noncompliance 14.40 10.40 267 572095 29464 46084236
Complication of device insertion 14.38 10.40 24 572338 4920 46108780
Oral disorder 14.38 10.40 153 572209 7669 46106031
Complication of device removal 14.30 10.40 13 572349 3477 46110223
Post procedural infection 14.30 10.40 148 572214 7365 46106335
Tooth abscess 14.29 10.40 226 572136 12407 46101293
Osteonecrosis of external auditory canal 14.27 10.40 11 572351 90 46113610
Groin pain 14.26 10.40 172 572190 8893 46104807
Unintended pregnancy 14.24 10.40 30 572332 5630 46108070
Squamous cell carcinoma of skin 14.24 10.40 110 572252 5037 46108663
Cardiac failure acute 14.19 10.40 51 572311 8027 46105673
Arrhythmia 14.17 10.40 322 572040 34519 46079181
Ulna fracture 14.13 10.40 37 572325 1049 46112651
Bradypnoea 14.11 10.40 10 572352 3029 46110671
Hand fracture 14.10 10.40 99 572263 4397 46109303
Dental prosthesis placement 14.09 10.40 10 572352 71 46113629
Liver transplant 14.05 10.40 6 572356 2411 46111289
Uterine prolapse 14.05 10.40 38 572324 1099 46112601
Clavicle fracture 14.00 10.40 72 572290 2857 46110843
Dehydration 14.00 10.40 1727 570635 157813 45955887
Closed fracture manipulation 13.99 10.40 7 572355 23 46113677
Tonsillar disorder 13.93 10.40 34 572328 922 46112778
Laryngitis 13.89 10.40 175 572187 9141 46104559
Limb hypoplasia congenital 13.88 10.40 14 572348 169 46113531
Eye infection 13.87 10.40 172 572190 8951 46104749
Knee operation 13.82 10.40 103 572259 4663 46109037
Stress cardiomyopathy 13.77 10.40 49 572313 7735 46105965
Seasonal allergy 13.77 10.40 235 572127 13099 46100601
Blood lactate dehydrogenase increased 13.72 10.40 173 572189 20327 46093373
Osteomalacia 13.71 10.40 27 572335 630 46113070
Ketoacidosis 13.67 10.40 17 572345 3938 46109762
Hormone replacement therapy 13.66 10.40 5 572357 5 46113695
Precancerous condition 13.66 10.40 4 572358 0 46113700
Gastroenteritis astroviral 13.66 10.40 4 572358 0 46113700
Radial nerve injury 13.66 10.40 4 572358 0 46113700
Vascular calcification 13.61 10.40 28 572334 675 46113025
Fluid retention 13.61 10.40 500 571862 50546 46063154
Chondropathy 13.60 10.40 54 572308 1916 46111784
Gait disturbance 13.59 10.40 2005 570357 143258 45970442
Pulmonary haemorrhage 13.58 10.40 38 572324 6467 46107233
Clear cell renal cell carcinoma 13.55 10.40 35 572327 984 46112716
Inadequate analgesia 13.50 10.40 9 572353 2815 46110885
Intestinal stenosis 13.49 10.40 64 572298 2457 46111243
Vitamin D increased 13.48 10.40 20 572342 368 46113332
Type IIa hyperlipidaemia 13.45 10.40 10 572352 77 46113623
Toxic encephalopathy 13.44 10.40 26 572336 5036 46108664
Heparin-induced thrombocytopenia 13.40 10.40 20 572342 4289 46109411
Speech disorder 13.40 10.40 339 572023 35828 46077872
Spinal disorder 13.40 10.40 154 572208 7870 46105830
Seborrhoeic keratosis 13.33 10.40 52 572310 1830 46111870
Periodontal operation 13.31 10.40 8 572354 41 46113659
Ear pain 13.29 10.40 360 572002 21732 46091968
Pulmonary alveolar haemorrhage 13.26 10.40 19 572343 4143 46109557
Cytokine release syndrome 13.26 10.40 36 572326 6187 46107513
Temperature regulation disorder 13.20 10.40 13 572349 3347 46110353
Polyhydramnios 13.17 10.40 54 572308 1945 46111755
Hypothyroidism 13.16 10.40 489 571873 30849 46082851
Tenosynovitis stenosans 13.12 10.40 53 572309 1896 46111804
Biliary dyskinesia 13.04 10.40 9 572353 2764 46110936
Hepatic necrosis 13.02 10.40 31 572331 5570 46108130
Hypoaesthesia 13.00 10.40 1656 570706 117213 45996487
Neck pain 13.00 10.40 815 571547 54491 46059209
Generalised tonic-clonic seizure 13.00 10.40 244 572118 26878 46086822
Muscle rupture 12.99 10.40 55 572307 2010 46111690
Renal tubular necrosis 12.93 10.40 78 572284 10681 46103019
Kidney transplant rejection 12.92 10.40 19 572343 4099 46109601
Congenital oral malformation 12.90 10.40 14 572348 185 46113515
Hysterosalpingo-oophorectomy 12.88 10.40 8 572354 44 46113656
Cartilage injury 12.87 10.40 46 572316 1551 46112149
Dialysis 12.87 10.40 72 572290 10044 46103656
Enthesopathy 12.84 10.40 100 572262 4590 46109110
Blood urea increased 12.80 10.40 226 572136 25126 46088574
Haemodynamic instability 12.77 10.40 50 572312 7675 46106025
Nodule 12.66 10.40 265 572097 15340 46098360
Right ventricular failure 12.66 10.40 131 572231 15962 46097738
Maternal drugs affecting foetus 12.63 10.40 113 572249 5405 46108295
Joint dislocation 12.61 10.40 200 572162 10986 46102714
Folate deficiency 12.60 10.40 48 572314 1670 46112030
Dairy intolerance 12.60 10.40 8 572354 46 46113654
Micturition urgency 12.59 10.40 149 572213 7668 46106032
Thyroid mass 12.58 10.40 76 572286 3205 46110495
Hypoglycaemic coma 12.58 10.40 8 572354 2566 46111134
Oedema peripheral 12.53 10.40 1741 570621 157965 45955735
Acute lymphocytic leukaemia recurrent 12.50 10.40 5 572357 2090 46111610
Multiple-drug resistance 12.50 10.40 8 572354 2557 46111143
Blood pressure diastolic abnormal 12.46 10.40 125 572237 6169 46107531
Diabetic ketoacidosis 12.44 10.40 153 572209 18057 46095643
Activated partial thromboplastin time prolonged 12.43 10.40 43 572319 6846 46106854
Complication associated with device 12.43 10.40 125 572237 15316 46098384
Gingivitis 12.41 10.40 144 572218 7376 46106324
Hepatitis C 12.40 10.40 38 572324 6280 46107420
Blood calcium increased 12.39 10.40 145 572217 7442 46106258
Enterococcal infection 12.35 10.40 44 572318 6943 46106757
Drug ineffective for unapproved indication 12.34 10.40 135 572227 16278 46097422
Appendix disorder 12.31 10.40 39 572323 1235 46112465
Rectocele 12.30 10.40 31 572331 858 46112842
Dry mouth 12.29 10.40 806 571556 54120 46059580
Incorrect product administration duration 12.27 10.40 68 572294 9509 46104191
Neutropenic colitis 12.26 10.40 6 572356 2226 46111474
Acute coronary syndrome 12.25 10.40 74 572288 10130 46103570
Pupil fixed 12.24 10.40 3 572359 1717 46111983
Capillary leak syndrome 12.22 10.40 4 572358 1893 46111807
Atrioventricular block complete 12.21 10.40 50 572312 7577 46106123
Knee deformity 12.20 10.40 29 572333 773 46112927
Scleritis 12.17 10.40 69 572293 2843 46110857
Cystocele 12.16 10.40 37 572325 1146 46112554
Steroid therapy 12.13 10.40 9 572353 69 46113631
Virologic failure 12.11 10.40 5 572357 2050 46111650
Paraesthesia 12.08 10.40 1630 570732 115807 45997893
Graft versus host disease in skin 12.07 10.40 7 572355 2360 46111340
Arthropod bite 12.05 10.40 117 572245 5724 46107976
Chest pain 12.04 10.40 1938 570424 174386 45939314
Basosquamous carcinoma 12.03 10.40 5 572357 9 46113691
Acute graft versus host disease in intestine 11.97 10.40 3 572359 1692 46112008
Product substitution issue 11.97 10.40 122 572240 14909 46098791
Urinary bladder suspension 11.93 10.40 17 572345 301 46113399
Oophorectomy 11.89 10.40 21 572341 450 46113250
Spinal stenosis 11.86 10.40 218 572144 12325 46101375
Pollakiuria 11.79 10.40 385 571977 23876 46089824
Therapeutic product effect incomplete 11.78 10.40 812 571550 77341 46036359
Isosthenuria 11.77 10.40 11 572351 120 46113580
Carpal tunnel decompression 11.71 10.40 29 572333 794 46112906
Bladder hypertrophy 11.65 10.40 14 572348 208 46113492
Meniscus removal 11.63 10.40 7 572355 36 46113664
Accidental death 11.59 10.40 4 572358 1831 46111869
Purpura 11.55 10.40 73 572289 9885 46103815
Breast disorder 11.54 10.40 51 572311 1900 46111800
Joint warmth 11.53 10.40 38 572324 1229 46112471
Erysipelas 11.51 10.40 133 572229 6805 46106895
Inflammatory bowel disease 11.51 10.40 73 572289 3132 46110568
Diverticulum intestinal 11.50 10.40 119 572243 5922 46107778
Congenital arterial malformation 11.46 10.40 18 572344 349 46113351
Posterior tibial tendon dysfunction 11.45 10.40 4 572358 3 46113697
Radical mastectomy 11.45 10.40 4 572358 3 46113697
Heart rate increased 11.45 10.40 776 571586 74015 46039685
Oestrogen deficiency 11.45 10.40 12 572350 152 46113548
Cystic fibrosis 11.44 10.40 81 572281 3607 46110093
Pre-eclampsia 11.43 10.40 149 572213 7845 46105855
Parathyroidectomy 11.42 10.40 15 572347 245 46113455
Vertebral wedging 11.39 10.40 5 572357 11 46113689
Acute chest syndrome 11.39 10.40 23 572339 547 46113153
Hospitalisation 11.39 10.40 648 571714 62737 46050963
Actinic keratosis 11.38 10.40 56 572306 2183 46111517
Sudden death 11.37 10.40 69 572293 9435 46104265
Muscle discomfort 11.35 10.40 9 572353 77 46113623
Injection site urticaria 11.32 10.40 208 572154 11759 46101941
Melanocytic naevus 11.29 10.40 84 572278 3801 46109899
Second primary malignancy 11.28 10.40 42 572320 6542 46107158
Pulpitis dental 11.25 10.40 28 572334 769 46112931
Immunosuppression 11.23 10.40 141 572221 7359 46106341
Hiatus hernia 11.23 10.40 299 572063 18003 46095697
Lower limb fracture 11.21 10.40 214 572148 12184 46101516
Visual acuity reduced 11.21 10.40 197 572165 21916 46091784
Breast feeding 11.19 10.40 30 572332 863 46112837
Exostosis of jaw 11.18 10.40 37 572325 1199 46112501
Epstein-Barr virus infection 11.16 10.40 44 572318 6740 46106960
Pseudarthrosis 11.16 10.40 19 572343 395 46113305
Alcohol poisoning 11.15 10.40 7 572355 2261 46111439
Pneumothorax 11.13 10.40 120 572242 14509 46099191
Varicose vein operation 11.12 10.40 6 572356 24 46113676
Cervical incompetence 11.12 10.40 24 572338 599 46113101
Kyphoscoliosis 11.12 10.40 20 572342 435 46113265
Nerve compression 11.10 10.40 131 572231 6737 46106963
Animal bite 11.10 10.40 57 572305 2260 46111440
Klebsiella infection 11.09 10.40 43 572319 6619 46107081
Withdrawal syndrome 11.06 10.40 156 572206 17978 46095722
Haematochezia 11.05 10.40 564 571798 36929 46076771
Gingival pain 11.04 10.40 119 572243 5984 46107716
Decreased immune responsiveness 10.99 10.40 79 572283 3536 46110164
Trigger finger 10.91 10.40 76 572286 3366 46110334
Back disorder 10.90 10.40 165 572197 8976 46104724
Pulmonary toxicity 10.88 10.40 26 572336 4667 46109033
Dermatitis allergic 10.88 10.40 216 572146 12387 46101313
Sinus disorder 10.86 10.40 273 572089 16290 46097410
Gastrointestinal toxicity 10.86 10.40 23 572339 4308 46109392
Disturbance in attention 10.85 10.40 299 572063 31261 46082439
Blood calcium abnormal 10.84 10.40 29 572333 833 46112867
Tendon disorder 10.78 10.40 101 572261 4894 46108806
Catheter management 10.77 10.40 11 572351 2784 46110916
Pseudomembranous colitis 10.77 10.40 14 572348 3181 46110519
Otospondylomegaepiphyseal dysplasia 10.74 10.40 9 572353 84 46113616
Drug intolerance 10.73 10.40 1610 570752 145439 45968261
Red blood cell count decreased 10.72 10.40 496 571866 32127 46081573
Ingrown hair 10.71 10.40 20 572342 448 46113252
Cleft palate 10.69 10.40 30 572332 887 46112813
Joint lock 10.67 10.40 52 572310 2019 46111681
Goitre 10.62 10.40 106 572256 5225 46108475
Perineurial cyst 10.59 10.40 6 572356 27 46113673
Mean cell haemoglobin concentration abnormal 10.57 10.40 5 572357 14 46113686
Oesophageal discomfort 10.53 10.40 12 572350 168 46113532
Bowel movement irregularity 10.50 10.40 75 572287 3350 46110350
Spinal operation 10.48 10.40 109 572253 5431 46108269
Pyelitis 10.47 10.40 12 572350 169 46113531
Spinal pain 10.46 10.40 175 572187 9717 46103983
Dental necrosis 10.45 10.40 11 572351 140 46113560
Joint stiffness 10.43 10.40 419 571943 26689 46087011
Endophthalmitis 10.41 10.40 15 572347 3263 46110437
Renal cyst 10.40 10.40 158 572204 8601 46105099
Decreased appetite 10.40 10.40 2158 570204 191678 45922022

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 499.32 10.46 42 239356 82030 29631050
Toxicity to various agents 475.67 10.46 430 238968 176753 29536327
Completed suicide 451.12 10.46 119 239279 99373 29613707
Rheumatoid arthritis 219.79 10.46 777 238621 40420 29672660
Intentional overdose 159.16 10.46 66 239332 41415 29671665
Drug interaction 141.44 10.46 974 238424 198594 29514486
Arthralgia 136.59 10.46 1672 237726 134119 29578961
Overdose 132.31 10.46 299 239099 84038 29629042
Suicide attempt 108.17 10.46 81 239317 36616 29676464
Osteonecrosis of jaw 100.82 10.46 353 239045 18265 29694815
Fatigue 100.26 10.46 3308 236090 317365 29395715
Foetal exposure during pregnancy 96.30 10.46 563 238835 36308 29676772
Death 94.46 10.46 2157 237241 355126 29357954
Hepatic function abnormal 94.13 10.46 118 239280 41827 29671253
Cardiac arrest 89.67 10.46 409 238989 92441 29620639
Infective pulmonary exacerbation of cystic fibrosis 87.14 10.46 204 239194 8368 29704712
Respiratory arrest 83.16 10.46 67 239331 29191 29683889
Fall 82.71 10.46 1969 237429 179903 29533177
Coma 79.59 10.46 125 239273 40324 29672756
Drug resistance 77.27 10.46 32 239366 20101 29692979
Nasopharyngitis 75.68 10.46 761 238637 58088 29654992
Psoriatic arthropathy 74.53 10.46 286 239112 15475 29697605
Drug reaction with eosinophilia and systemic symptoms 72.85 10.46 72 239326 28416 29684664
Multiple sclerosis relapse 70.49 10.46 219 239179 10643 29702437
Multiple organ dysfunction syndrome 61.65 10.46 279 239119 63208 29649872
Renal failure 59.73 10.46 701 238697 128265 29584815
Intentional product misuse 59.26 10.46 117 239281 34550 29678530
Sickle cell anaemia with crisis 59.19 10.46 84 239314 2318 29710762
Peripheral swelling 58.68 10.46 746 238652 60328 29652752
Rhabdomyolysis 57.30 10.46 287 239111 63293 29649787
Cardio-respiratory arrest 53.77 10.46 255 239143 57051 29656029
Cytomegalovirus infection 51.66 10.46 68 239330 23606 29689474
Basal cell carcinoma 51.15 10.46 259 239139 15809 29697271
Joint swelling 51.00 10.46 587 238811 46359 29666721
Drug withdrawal syndrome 49.58 10.46 51 239347 19758 29693322
Serotonin syndrome 49.56 10.46 42 239356 17849 29695231
Lactic acidosis 48.62 10.46 111 239287 31102 29681978
Vitamin D deficiency 48.21 10.46 119 239279 5051 29708029
Poisoning 47.18 10.46 16 239382 11366 29701714
Hypocalcaemia 46.78 10.46 312 239086 21064 29692016
Toxic epidermal necrolysis 46.26 10.46 45 239353 17895 29695185
Back pain 44.49 10.46 1104 238294 101492 29611588
Blood pressure fluctuation 44.22 10.46 265 239133 17238 29695842
Product dose omission issue 43.68 10.46 999 238399 90632 29622448
Myocardial infarction 41.84 10.46 729 238669 124896 29588184
Intentional self-injury 41.00 10.46 29 239369 13503 29699577
Shock 40.07 10.46 76 239322 22783 29690297
Acute kidney injury 39.90 10.46 1786 237612 272056 29441024
Disseminated intravascular coagulation 39.49 10.46 73 239325 22098 29690982
Tenosynovitis 39.44 10.46 87 239311 3428 29709652
Sinusitis 39.43 10.46 424 238974 32921 29680159
Altered state of consciousness 38.76 10.46 62 239336 19857 29693223
Neonatal respiratory distress syndrome 38.10 10.46 93 239305 3919 29709161
Drug dependence 38.03 10.46 70 239328 21225 29691855
Hepatic failure 37.14 10.46 143 239255 33900 29679180
Pathogen resistance 36.31 10.46 11 239387 8399 29704681
Enthesopathy 36.15 10.46 75 239323 2831 29710249
Musculoskeletal stiffness 36.04 10.46 442 238956 35439 29677641
Febrile neutropenia 35.88 10.46 618 238780 106075 29607005
Stevens-Johnson syndrome 35.73 10.46 53 239345 17503 29695577
Angioedema 35.26 10.46 148 239250 34236 29678844
Osteoarthritis 34.99 10.46 259 239139 18090 29694990
Psoriasis 34.58 10.46 504 238894 42002 29671078
Hypotension 34.08 10.46 1285 238113 199280 29513800
Depressed level of consciousness 33.03 10.46 175 239223 38047 29675033
Substance abuse 32.67 10.46 8 239390 7032 29706048
Atrial septal defect 32.01 10.46 122 239276 6579 29706501
Neurotoxicity 31.80 10.46 35 239363 13147 29699933
Vitamin D decreased 31.57 10.46 67 239331 2570 29710510
Arthritis 31.56 10.46 316 239082 24085 29688995
Suicidal ideation 30.84 10.46 166 239232 35948 29677132
Agitation 30.70 10.46 280 239118 53793 29659287
Pain 30.70 10.46 1680 237718 170961 29542119
Maternal exposure during breast feeding 30.23 10.46 50 239348 1582 29711498
Blood creatine phosphokinase increased 29.96 10.46 216 239182 43632 29669448
Maternal exposure during pregnancy 29.85 10.46 83 239315 3788 29709292
Premature baby 29.80 10.46 232 239166 16459 29696621
Influenza 29.75 10.46 500 238898 42898 29670182
Wound 29.58 10.46 185 239213 12217 29700863
Weight decreased 29.52 10.46 1482 237916 149439 29563641
Bone giant cell tumour 29.19 10.46 13 239385 53 29713027
Spinal fracture 29.12 10.46 119 239279 6629 29706451
Sopor 29.00 10.46 27 239371 10964 29702116
Colitis ulcerative 28.82 10.46 206 239192 14228 29698852
Cardiac failure 28.75 10.46 481 238917 82937 29630143
Hypoglycaemia neonatal 28.66 10.46 48 239350 1535 29711545
Cataract 28.35 10.46 283 239115 21552 29691528
Immune reconstitution inflammatory syndrome 28.24 10.46 19 239379 9082 29703998
Exposure during pregnancy 27.89 10.46 147 239251 9114 29703966
Hypospadias 27.49 10.46 64 239334 2615 29710465
Skin cancer 27.24 10.46 131 239267 7830 29705250
Musculoskeletal pain 27.22 10.46 372 239026 30568 29682512
Pneumonia 27.22 10.46 3060 236338 331246 29381834
Neuroleptic malignant syndrome 26.99 10.46 56 239342 16239 29696841
Poisoning deliberate 26.83 10.46 7 239391 5897 29707183
Maternal drugs affecting foetus 26.66 10.46 85 239313 4188 29708892
Osteoporosis 26.65 10.46 161 239237 10502 29702578
Small for dates baby 25.95 10.46 70 239328 3138 29709942
Coronary artery disease 25.85 10.46 263 239135 49449 29663631
Blood iron decreased 25.79 10.46 81 239317 3959 29709121
Urinary tract infection 25.22 10.46 769 238629 72890 29640190
Prostate cancer 24.87 10.46 297 239101 23660 29689420
Femur fracture 24.81 10.46 120 239278 7189 29705891
Renal impairment 24.75 10.46 499 238899 83685 29629395
Pulmonary fibrosis 24.68 10.46 214 239184 15676 29697404
Venoocclusive liver disease 24.59 10.46 11 239387 6602 29706478
Mucormycosis 24.42 10.46 6 239392 5262 29707818
Nephrolithiasis 24.21 10.46 304 239094 24506 29688574
Acute respiratory distress syndrome 24.08 10.46 101 239297 23371 29689709
Product use in unapproved indication 24.07 10.46 429 238969 73264 29639816
Foetal malformation 23.92 10.46 15 239383 137 29712943
Dysmorphism 23.86 10.46 51 239347 1966 29711114
Anaphylactic shock 23.25 10.46 48 239350 13945 29699135
Syndactyly 23.09 10.46 29 239369 709 29712371
General physical health deterioration 23.08 10.46 998 238400 98946 29614134
Vomiting 23.06 10.46 1481 237917 218337 29494743
Full blood count decreased 23.03 10.46 209 239189 15508 29697572
Cryptorchism 22.91 10.46 45 239353 1632 29711448
Post transplant lymphoproliferative disorder 22.80 10.46 7 239391 5299 29707781
Atypical fracture 22.62 10.46 12 239386 77 29713003
Sedation 22.56 10.46 62 239336 16311 29696769
Frequent bowel movements 22.35 10.46 129 239269 8276 29704804
Balance disorder 22.00 10.46 412 238986 36081 29676999
Status epilepticus 21.98 10.46 34 239364 11038 29702042
Hepatotoxicity 21.93 10.46 73 239325 18072 29695008
Eosinophilia 21.73 10.46 97 239301 22063 29691017
Metabolic acidosis 21.68 10.46 193 239205 37268 29675812
Red cell distribution width increased 21.62 10.46 77 239321 4017 29709063
Acute graft versus host disease 21.42 10.46 10 239388 5854 29707226
Fracture 21.40 10.46 100 239298 5906 29707174
Urosepsis 21.33 10.46 153 239245 10579 29702501
Squamous cell carcinoma of skin 21.27 10.46 135 239263 8960 29704120
Body height decreased 21.26 10.46 72 239326 3662 29709418
Low turnover osteopathy 20.98 10.46 12 239386 91 29712989
Blood creatinine increased 20.89 10.46 563 238835 90812 29622268
Drug eruption 20.84 10.46 71 239327 17455 29695625
Large for dates baby 20.81 10.46 30 239368 840 29712240
Respiratory failure 20.50 10.46 630 238768 100012 29613068
Prostatic specific antigen increased 20.41 10.46 165 239233 11839 29701241
Amino acid level increased 20.25 10.46 20 239378 371 29712709
Brain oedema 20.20 10.46 43 239355 12355 29700725
Asthenia 20.12 10.46 2041 237357 219249 29493831
Low birth weight baby 20.08 10.46 99 239299 5977 29707103
Emotional distress 20.04 10.46 62 239336 15703 29697377
Poor venous access 19.94 10.46 54 239344 2426 29710654
Upper respiratory tract infection 19.73 10.46 319 239079 27157 29685923
Electrocardiogram QT prolonged 19.71 10.46 187 239211 35648 29677432
Hypoglycaemia 19.56 10.46 288 239110 50693 29662387
Hyperkalaemia 19.48 10.46 391 239007 65619 29647461
Cystitis haemorrhagic 19.37 10.46 7 239391 4780 29708300
Tongue disorder 19.27 10.46 77 239321 4245 29708835
Pain in extremity 19.24 10.46 1071 238327 109150 29603930
Malignant melanoma 19.23 10.46 113 239285 7298 29705782
Ventricular septal defect 19.18 10.46 67 239331 3462 29709618
Hyperthermia 19.12 10.46 32 239366 10067 29703013
Bradycardia 19.08 10.46 389 239009 65137 29647943
Injury 19.05 10.46 99 239299 21632 29691448
Multiple sclerosis 18.98 10.46 111 239287 7156 29705924
Nephropathy toxic 18.97 10.46 35 239363 10604 29702476
Melanoderma 18.95 10.46 14 239384 171 29712909
Hypercalcaemia 18.74 10.46 167 239231 12328 29700752
Tendonitis 18.62 10.46 119 239279 7917 29705163
Chronic graft versus host disease 18.50 10.46 5 239393 4114 29708966
Neutropenia 18.31 10.46 840 238558 127700 29585380
Fear 18.10 10.46 37 239361 10788 29702292
Bronchopulmonary aspergillosis 18.08 10.46 45 239353 12239 29700841
Ventricular tachycardia 18.07 10.46 114 239284 23748 29689332
Rib fracture 18.06 10.46 168 239230 12552 29700528
Gastrointestinal stoma complication 18.05 10.46 35 239363 1257 29711823
Pancreatic failure 18.04 10.46 26 239372 728 29712352
Rash maculo-papular 17.95 10.46 124 239274 25294 29687786
Aspergillus infection 17.86 10.46 34 239364 10180 29702900
Psychotic disorder 17.76 10.46 100 239298 21415 29691665
Exposure via breast milk 17.74 10.46 39 239359 1533 29711547
Tachycardia 17.73 10.46 451 238947 73288 29639792
Cough 17.68 10.46 1198 238200 124444 29588636
Kidney infection 17.63 10.46 78 239320 4500 29708580
Trisomy 18 17.61 10.46 15 239383 228 29712852
Red blood cell count decreased 17.58 10.46 302 239096 26019 29687061
Foetal anticonvulsant syndrome 17.52 10.46 26 239372 748 29712332
Asphyxia 17.27 10.46 11 239387 5414 29707666
Alanine aminotransferase abnormal 17.17 10.46 53 239345 2566 29710514
Tooth fracture 16.93 10.46 61 239337 3201 29709879
Drug abuser 16.88 10.46 7 239391 4394 29708686
Alcohol abuse 16.85 10.46 11 239387 5342 29707738
Hypochromasia 16.76 10.46 17 239381 326 29712754
Lipodystrophy acquired 16.61 10.46 4 239394 3556 29709524
Psychomotor hyperactivity 16.57 10.46 25 239373 8199 29704881
Dystonia 16.47 10.46 33 239365 9694 29703386
Drug intolerance 16.35 10.46 476 238922 44815 29668265
Virologic failure 16.28 10.46 3 239395 3216 29709864
Lower respiratory tract infection 16.24 10.46 302 239096 26412 29686668
Intramedullary rod insertion 16.21 10.46 7 239391 26 29713054
Oesophageal adenocarcinoma 16.20 10.46 27 239371 860 29712220
Serum ferritin increased 16.16 10.46 86 239312 5351 29707729
Diverticular perforation 16.14 10.46 59 239339 3118 29709962
Memory impairment 16.08 10.46 400 238998 36774 29676306
Acute graft versus host disease in skin 16.04 10.46 8 239390 4508 29708572
Back disorder 15.94 10.46 92 239306 5902 29707178
Suspected suicide 15.87 10.46 3 239395 3158 29709922
Extrapyramidal disorder 15.87 10.46 39 239359 10654 29702426
Pyrexia 15.87 10.46 2087 237311 292402 29420678
Palmar-plantar erythrodysaesthesia syndrome 15.87 10.46 63 239335 14807 29698273
Hepatitis 15.82 10.46 109 239289 22247 29690833
Renal injury 15.72 10.46 45 239353 11684 29701396
Congenital hand malformation 15.69 10.46 19 239379 447 29712633
Immunodeficiency 15.67 10.46 72 239326 4222 29708858
Rhinorrhoea 15.67 10.46 243 239155 20511 29692569
Ventricular fibrillation 15.61 10.46 65 239333 15073 29698007
Sexual dysfunction 15.53 10.46 15 239383 5986 29707094
Phospholipidosis 15.51 10.46 8 239390 48 29713032
Juvenile idiopathic arthritis 15.49 10.46 29 239369 1014 29712066
Blood pressure systolic abnormal 15.46 10.46 36 239362 1471 29711609
Tumour lysis syndrome 15.46 10.46 52 239346 12833 29700247
Arthropathy 15.39 10.46 242 239156 20485 29692595
Left atrial enlargement 15.33 10.46 19 239379 458 29712622
Pulmonary alveolar haemorrhage 15.30 10.46 18 239380 6563 29706517
Clostridium difficile infection 15.23 10.46 193 239205 15590 29697490
Haemodialysis 15.20 10.46 42 239356 11031 29702049
Mydriasis 15.16 10.46 16 239382 6127 29706953
Medical device implantation 15.13 10.46 20 239378 515 29712565
Cellulitis 15.10 10.46 485 238913 46299 29666781
Cerebral haemorrhage 15.09 10.46 179 239219 32708 29680372
Graft versus host disease 15.08 10.46 37 239361 10113 29702967
Aggression 15.04 10.46 206 239192 36701 29676379
C-reactive protein abnormal 14.98 10.46 86 239312 5507 29707573
Complications of transplanted kidney 14.97 10.46 7 239391 4094 29708986
Drug-induced liver injury 14.92 10.46 104 239294 21170 29691910
Tonsil cancer 14.86 10.46 24 239374 744 29712336
Relapsing-remitting multiple sclerosis 14.83 10.46 14 239384 245 29712835
Cerebral infarction 14.77 10.46 137 239261 26236 29686844
Post procedural infection 14.76 10.46 74 239324 4498 29708582
Liver disorder 14.73 10.46 159 239239 29563 29683517
Haemodynamic instability 14.62 10.46 26 239372 7989 29705091
Cytomegalovirus chorioretinitis 14.62 10.46 4 239394 3264 29709816
Hypophosphatasia 14.61 10.46 6 239392 19 29713061
Angina pectoris 14.59 10.46 158 239240 29360 29683720
Periodontitis 14.57 10.46 38 239360 1669 29711411
Electrocardiogram QRS complex prolonged 14.57 10.46 8 239390 4269 29708811
Joint effusion 14.56 10.46 63 239335 3600 29709480
Impaired healing 14.54 10.46 177 239221 14163 29698917
Anhedonia 14.51 10.46 28 239370 8341 29704739
Somnolence 14.45 10.46 629 238769 96134 29616946
Viral acanthoma 14.39 10.46 6 239392 20 29713060
Ileal stenosis 14.36 10.46 30 239368 1138 29711942
Asthma 14.35 10.46 203 239195 35971 29677109
Torsade de pointes 14.35 10.46 22 239376 7168 29705912
Grip strength decreased 14.33 10.46 44 239354 2124 29710956
Drug level increased 14.25 10.46 87 239311 18267 29694813
Mitral valve thickening 14.17 10.46 13 239385 219 29712861
Febrile bone marrow aplasia 14.12 10.46 27 239371 8070 29705010
Delirium 14.08 10.46 234 239164 40397 29672683
Thrombocytopenia 14.05 10.46 925 238473 136119 29576961
Oropharyngeal pain 13.97 10.46 312 239086 28184 29684896
Contusion 13.95 10.46 338 239060 30942 29682138
Drug screen positive 13.94 10.46 9 239389 4398 29708682
Urticaria 13.93 10.46 331 239067 54275 29658805
Arthrodesis 13.84 10.46 17 239381 406 29712674
Acute generalised exanthematous pustulosis 13.84 10.46 17 239381 6081 29706999
Abdominal adhesions 13.83 10.46 32 239366 1302 29711778
Rheumatoid nodule 13.79 10.46 37 239361 1653 29711427
Withdrawal syndrome 13.77 10.46 45 239353 11205 29701875
Urine calcium/creatinine ratio increased 13.75 10.46 6 239392 23 29713057
Cystitis escherichia 13.74 10.46 12 239386 189 29712891
Coagulopathy 13.65 10.46 89 239309 18398 29694682
Inguinal hernia 13.64 10.46 101 239297 7054 29706026
Lacrimal disorder 13.64 10.46 15 239383 317 29712763
Hypertransaminasaemia 13.62 10.46 7 239391 3878 29709202
Cardiac failure congestive 13.59 10.46 544 238854 83863 29629217
Medication error 13.52 10.46 105 239293 20867 29692213
Cholelithiasis 13.48 10.46 232 239166 19993 29693087
Hyperglycaemia 13.45 10.46 199 239199 35001 29678079
Seasonal allergy 13.33 10.46 74 239324 4679 29708401
Jaundice neonatal 13.28 10.46 28 239370 1069 29712011
Graft versus host disease in gastrointestinal tract 13.28 10.46 4 239394 3065 29710015
Anal fistula 13.21 10.46 65 239333 3921 29709159
Mean cell volume increased 13.19 10.46 42 239356 2068 29711012
Haematotoxicity 13.18 10.46 18 239380 6152 29706928
Right atrial enlargement 13.17 10.46 13 239385 241 29712839
Tarsal tunnel syndrome 13.16 10.46 5 239393 12 29713068
Umbilical hernia 13.08 10.46 61 239337 3600 29709480
Disease progression 13.03 10.46 514 238884 79360 29633720
Arthropod bite 13.01 10.46 45 239353 2313 29710767
Hyperammonaemia 12.94 10.46 15 239383 5505 29707575
Hip fracture 12.94 10.46 141 239257 10983 29702097
Intestinal stenosis 12.91 10.46 39 239359 1866 29711214
Congenital hydronephrosis 12.89 10.46 21 239377 656 29712424
Selective eating disorder 12.88 10.46 36 239362 1648 29711432
Localised infection 12.84 10.46 167 239231 13570 29699510
Middle ear effusion 12.84 10.46 18 239380 491 29712589
Anuria 12.81 10.46 41 239357 10275 29702805
Synovitis 12.80 10.46 127 239271 9656 29703424
Blood 25-hydroxycholecalciferol decreased 12.70 10.46 7 239391 49 29713031
Hepatitis B 12.68 10.46 18 239380 6054 29707026
Fistula 12.59 10.46 77 239321 5045 29708035
Fibula fracture 12.58 10.46 22 239376 729 29712351
Injection site bruising 12.55 10.46 101 239297 7237 29705843
Distal intestinal obstruction syndrome 12.48 10.46 15 239383 350 29712730
Blood lactic acid increased 12.46 10.46 17 239381 5813 29707267
Lenticular opacities 12.44 10.46 12 239386 216 29712864
Haemangioma congenital 12.38 10.46 18 239380 508 29712572
Laboratory test abnormal 12.33 10.46 202 239196 17240 29695840
Wrong technique in product usage process 12.30 10.46 175 239223 30980 29682100
Ventricular hyperkinesia 12.26 10.46 12 239386 220 29712860
Loss of personal independence in daily activities 12.25 10.46 241 239157 21294 29691786
Mastitis 12.25 10.46 11 239387 180 29712900
Mobility decreased 12.22 10.46 283 239115 25716 29687364
Interstitial lung disease 12.21 10.46 377 239021 59820 29653260
Second primary malignancy 12.16 10.46 20 239378 6336 29706744
Monocyte percentage increased 12.11 10.46 24 239374 876 29712204
Acute hepatic failure 12.06 10.46 51 239347 11776 29701304
Hypersomnia 12.06 10.46 141 239257 11175 29701905
Unresponsive to stimuli 12.05 10.46 144 239254 26275 29686805
Talipes 12.02 10.46 35 239363 1640 29711440
Epstein-Barr virus infection 12.01 10.46 22 239376 6684 29706396
Squamous cell carcinoma 11.96 10.46 130 239268 10120 29702960
Phlebitis infective 11.96 10.46 10 239388 148 29712932
Cytomegalovirus viraemia 11.95 10.46 17 239381 5712 29707368
Venoocclusive disease 11.91 10.46 3 239395 2587 29710493
Exposed bone in jaw 11.85 10.46 37 239361 1803 29711277
Akathisia 11.84 10.46 18 239380 5886 29707194
Bradycardia neonatal 11.82 10.46 24 239374 892 29712188
Diabetic ketoacidosis 11.78 10.46 77 239321 15909 29697171
Weight decrease neonatal 11.77 10.46 14 239384 323 29712757
Lip ulceration 11.72 10.46 22 239376 771 29712309
Intervertebral disc degeneration 11.70 10.46 77 239321 5174 29707906
Bone density decreased 11.67 10.46 36 239362 1742 29711338
Hypermobility syndrome 11.67 10.46 12 239386 234 29712846
Mania 11.64 10.46 36 239362 9118 29703962
Diarrhoea 11.64 10.46 2922 236476 331181 29381899
Knee arthroplasty 11.62 10.46 81 239317 5549 29707531
Cardiogenic shock 11.54 10.46 83 239315 16778 29696302
Arthritis bacterial 11.54 10.46 68 239330 4396 29708684
Renal aplasia 11.54 10.46 20 239378 658 29712422
Apparent death 11.53 10.46 7 239391 3535 29709545
Hungry bone syndrome 11.53 10.46 7 239391 60 29713020
Excessive skin 11.51 10.46 3 239395 0 29713080
External ear inflammation 11.51 10.46 3 239395 0 29713080
Menopausal symptoms 11.51 10.46 3 239395 0 29713080
Hypnopompic hallucination 11.51 10.46 3 239395 0 29713080
Cardiotoxicity 11.46 10.46 11 239387 4403 29708677
Hepatitis cholestatic 11.46 10.46 29 239369 7843 29705237
Agranulocytosis 11.44 10.46 116 239282 21826 29691254
Incorrect route of product administration 11.41 10.46 49 239349 11266 29701814
Atypical fibroxanthoma 11.40 10.46 11 239387 198 29712882
Toxic encephalopathy 11.38 10.46 12 239386 4597 29708483
Product complaint 11.36 10.46 18 239380 5788 29707292
Haematochezia 11.36 10.46 356 239042 33866 29679214
Folate deficiency 11.35 10.46 25 239373 984 29712096
Hydrocele 11.27 10.46 39 239359 2005 29711075
Pharyngitis bacterial 11.25 10.46 6 239392 39 29713041
Hepatitis fulminant 11.23 10.46 9 239389 3932 29709148
Exostosis 11.21 10.46 56 239342 3399 29709681
Product quality issue 11.18 10.46 96 239302 18678 29694402
Congenital bladder anomaly 11.16 10.46 13 239385 293 29712787
Chronic gastrointestinal bleeding 11.16 10.46 12 239386 247 29712833
Limb discomfort 11.13 10.46 116 239282 8934 29704146
Mental status changes 11.12 10.46 219 239179 36860 29676220
Weight gain poor 11.11 10.46 23 239375 867 29712213
Narcolepsy 11.10 10.46 16 239382 448 29712632
Hypoaesthesia 11.09 10.46 535 238863 53695 29659385
Agitation neonatal 11.09 10.46 25 239373 1000 29712080
Accessory spleen 11.02 10.46 10 239388 166 29712914
Bone density abnormal 10.98 10.46 7 239391 66 29713014
Steatorrhoea 10.95 10.46 20 239378 686 29712394
Bone metabolism disorder 10.82 10.46 12 239386 256 29712824
Blood bilirubin increased 10.81 10.46 217 239181 36419 29676661
Restlessness 10.76 10.46 122 239276 22477 29690603
Respiratory distress 10.74 10.46 192 239206 32780 29680300
Bronchitis 10.71 10.46 398 239000 38727 29674353
Gait disturbance 10.68 10.46 714 238684 74063 29639017
Maternal exposure before pregnancy 10.67 10.46 14 239384 358 29712722
Thyroid mass 10.67 10.46 14 239384 358 29712722
Drug ineffective 10.62 10.46 2485 236913 337902 29375178
Tooth disorder 10.60 10.46 116 239282 9045 29704035
Adverse drug reaction 10.59 10.46 251 239147 22894 29690186
Periorbital inflammation 10.59 10.46 5 239393 24 29713056
Haemoglobin decreased 10.57 10.46 1054 238344 113044 29600036
Hepatitis C 10.56 10.46 62 239336 13143 29699937
Night sweats 10.55 10.46 169 239229 14359 29698721
Posterior reversible encephalopathy syndrome 10.54 10.46 35 239363 8672 29704408
Blood test abnormal 10.54 10.46 78 239320 5447 29707633
Stress fracture 10.52 10.46 22 239376 835 29712245
Sinus operation 10.50 10.46 19 239379 647 29712433

Pharmacologic Action:

SourceCodeDescription
ATC A11CC05 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC A11CC55 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC M05BB03 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB05 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB07 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB08 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB09 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BX53 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Other drugs affecting bone structure and mineralization
FDA CS M0022797 Vitamin D
MeSH PA D050071 Bone Density Conservation Agents
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins
FDA EPC N0000175952 Vitamin D
CHEBI has role CHEBI:77746 h. sapiens metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Osteomalacia indication 4598005 DOID:10573
Hypocalcemia indication 5291005
Vitamin D deficiency indication 34713006
Hypoparathyroidism indication 36976004 DOID:11199
Rickets indication 41345002 DOID:10609
Osteoporosis indication 64859006 DOID:11476
Vitamin deficiency indication 85670002
Postmenopausal osteoporosis indication 102447009
Prevention of dental caries indication 426482000
Glucocorticoid Induced Osteoporosis indication
Hypogonadal Osteoporosis in Males indication
Vitamin D Dependent Rickets indication
Renal osteodystrophy off-label use 16726004 DOID:13068
Anticonvulsant-induced Osteomalacia off-label use
Gastritis contraindication 4556007 DOID:4029
Poisoning by digitalis glycoside contraindication 12876009
Constipation contraindication 14760008 DOID:2089
Esophagitis contraindication 16761005 DOID:11963
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Dental fluorosis contraindication 30265004
Ulcer of esophagus contraindication 30811009
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Atrial fibrillation contraindication 49436004 DOID:0060224
Vitamin E deficiency contraindication 54137008
Hyperlipidemia contraindication 55822004 DOID:1168
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Stricture of esophagus contraindication 63305008
Hypervitaminosis A contraindication 64559002 DOID:9972
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Fracture of femur contraindication 71620000
Hypercalciuria contraindication 71938000
Duodenitis contraindication 72007001 DOID:8643
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Neoplasm of endometrium contraindication 123844007 DOID:1380
Neoplasm of prostate contraindication 126906006 DOID:10283
Hb SS disease contraindication 127040003 DOID:10923
Bed-ridden contraindication 160685001
Acute peptic ulcer contraindication 196682000
Osteolysis contraindication 203522001
Disease of liver contraindication 235856003 DOID:409
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Malignant tumor of cervix contraindication 363354003 DOID:4362
Hemochromatosis contraindication 399187006 DOID:2352
Central nervous system depression contraindication 418072004
Aseptic necrosis of bone of jaw contraindication 441809006
Carcinoma of female breast contraindication 447782002
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication
Malabsorption States contraindication
High Grade Dysplasia associated with Barrett's Esophagus contraindication
Esophageal Obstruction contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST EC50 9.68 CHEMBL CHEMBL
Sterol 26-hydroxylase, mitochondrial Enzyme WOMBAT-PK
Vitamin D 25-hydroxylase Enzyme WOMBAT-PK
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Enzyme WOMBAT-PK
Glycine receptor subunit alpha-1 Ion channel EC50 6.40 CHEMBL

External reference:

IDSource
D00188 KEGG_DRUG
4017667 VANDF
C0008318 UMLSCUI
CHEBI:28940 CHEBI
VD3 PDB_CHEM_ID
CHEMBL1042 ChEMBL_ID
DB00169 DRUGBANK_ID
D002762 MESH_DESCRIPTOR_UI
5280795 PUBCHEM_CID
1497 INN_ID
1C6V77QF41 UNII
2747 IUPHAR_LIGAND_ID
1244014 RXNORM
15676 MMSL
199274 MMSL
4434 MMSL
4868 MMSL
4871 MMSL
d03129 MMSL
001014 NDDF
108943009 SNOMEDCT_US
18414002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0270 TABLET 5600 [iU] ORAL NDA 27 sections
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0710 TABLET 2800 [iU] ORAL NDA 27 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 400 [iU] ORAL Unapproved drug other 12 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 400 [iU] ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 400 [iU] ORAL UNULLPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 400 [iU] ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 400 [iU] ORAL Unapproved drug other 11 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 200 [iU] ORAL unapproved drug other 10 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 400 [iU] ORAL UNULLPPROVED DRUG OTHER 14 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 25 ug ORAL UNULLPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 25 ug ORAL UNULLPPROVED DRUG OTHER 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 400 [iU] ORAL UNULLPPROVED DRUG OTHER 13 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 1000 [iU] ORAL UNULLPPROVED DRUG OTHER 14 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 4 0642-7468 STRIP 1000 [iU] ORAL Unapproved drug other 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 25 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 400 [iU] ORAL UNULLPPROVED DRUG OTHER 4 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 400 [iU] ORAL UNULLPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 2000 [iU] ORAL Unapproved drug other 7 sections
PRENULLTAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 400 [iU] ORAL unapproved drug other 8 sections
PRENULLTAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 400 [iU] ORAL UNULLPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 400 [iU] ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 400 [iU] ORAL unapproved drug other 16 sections
PRENULLTAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 15338-522 TABLET, FILM COATED 400 [iU] ORAL unapproved drug other 8 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 400 [iU] ORAL UNULLPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 400 [iU] ORAL UNULLPPROVED DRUG OTHER 11 sections
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 14 15370-102 LIQUID 400 [iU] ORAL UNULLPPROVED DRUG OTHER 11 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-103 TABLET, CHEWABLE 400 [iU] ORAL UNULLPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-104 TABLET, CHEWABLE 400 [iU] ORAL UNULLPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-105 TABLET, CHEWABLE 400 [iU] ORAL UNULLPPROVED DRUG OTHER 12 sections
TriStart DHA HUMAN PRESCRIPTION DRUG LABEL 15 15370-250 CAPSULE, LIQUID FILLED 1000 [iU] ORAL UNULLPPROVED DRUG OTHER 12 sections