tolonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quaternary ammonium compounds 2701 92-31-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tolonium
  • dimethyltoluthionine chloride
  • tolazul
  • tolonium chloride
  • toluidine blue
A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery.
  • Molecular weight: 270.37
  • Formula: C15H16N3S
  • CLOGP: -2.55
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 42.15
  • ALOGS: -2.99
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003029 Coagulants
MeSH PA D004396 Coloring Agents
MeSH PA D006401 Hematologic Agents
MeSH PA D006490 Hemostatics
MeSH PA D006494 Heparin Antagonists
CHEBI has role CHEBI:33295 diagnostic aid
CHEBI has role CHEBI:51217 fluorochromes
CHEBI has role CHEBI:77178 biological stain

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.51 Basic
pKa2 3.89 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Microtubule-associated protein tau Structural Ki 7.16 CHEMBL
Zinc finger protein mex-5 Cytosolic other EC50 4.45 CHEMBL

External reference:

IDSource
N0000167280 NUI
3209-30-1 SECONDARY_CAS_RN
4040795 VANDF
C0040380 UMLSCUI
CHEBI:87647 CHEBI
CHEMBL1197206 ChEMBL_ID
CHEMBL1622638 ChEMBL_ID
CHEMBL1790006 ChEMBL_ID
7084 PUBCHEM_CID
P3Y6XJA2D1 UNII
10638 RXNORM
NOCODE MMSL
002095 NDDF
29522004 SNOMEDCT_US
417083005 SNOMEDCT_US
D014048 MESH_DESCRIPTOR_UI
231 INN_ID
56109-24-1 SECONDARY_CAS_RN

Pharmaceutical products:

None