teprenone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2596 6809-52-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tetraprenylacetone
  • tetraprenyl acetone
  • teprenone
  • geranylgeranylacetone
  • selbex
; RN given refers to isomeric cpd without isomeric designation; mixture of (5E,9E,13E) & (5Z,9E,13E)-isomers
  • Molecular weight: 330.56
  • Formula: C23H38O
  • CLOGP: 7.92
  • LIPINSKI: None
  • HAC: 1
  • HDO: 0
  • TPSA: 17.07
  • ALOGS: -5.32
  • ROTB: 12

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 68.16 25.04 33 2485 32648 50569958
Interstitial lung disease 63.48 25.04 37 2481 53139 50549467
Platelet count decreased 46.26 25.04 39 2479 100687 50501919
Renal impairment 40.41 25.04 32 2486 75629 50526977
Upper respiratory tract inflammation 38.95 25.04 11 2507 2378 50600228
Anaemia 37.66 25.04 54 2464 252402 50350204
White blood cell count decreased 37.52 25.04 37 2481 116685 50485921
Cerebral haemorrhage 32.71 25.04 19 2499 27033 50575573
Pyrexia 25.08 25.04 57 2461 380146 50222460

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Platelet count decreased 55.20 23.36 51 2045 104621 29467810
Hepatic function abnormal 41.92 23.36 29 2067 39230 29533201
Anaemia 41.04 23.36 60 2036 200891 29371540
Liver disorder 30.79 23.36 21 2075 27728 29544703
Neutrophil count decreased 26.37 23.36 23 2073 43544 29528887
White blood cell count decreased 24.79 23.36 30 2066 83332 29489099
Decreased appetite 24.78 23.36 40 2056 145302 29427129

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 97.13 21.59 61 4933 64252 64429486
Platelet count decreased 92.02 21.59 87 4907 167624 64326114
Anaemia 66.76 21.59 111 4883 378569 64115169
Interstitial lung disease 63.89 21.59 56 4938 97676 64396062
White blood cell count decreased 57.82 21.59 66 4928 157771 64335967
Renal impairment 48.65 21.59 56 4938 134961 64358777
Upper respiratory tract inflammation 48.33 21.59 16 4978 3766 64489972
Liver disorder 46.17 21.59 36 4958 53315 64440423
Hyperuricaemia 39.11 21.59 18 4976 10173 64483565
Neutrophil count decreased 38.37 21.59 38 4956 77158 64416580
Drug eruption 34.81 21.59 26 4968 36110 64457628
Pyrexia 34.50 21.59 108 4886 558536 63935202
Enterocolitis 33.35 21.59 17 4977 12001 64481737
Cerebral haemorrhage 32.79 21.59 29 4965 51061 64442677
Fatigue 30.63 21.59 10 4984 748720 63745018
Cerebral infarction 29.79 21.59 25 4969 41019 64452719
Erythema multiforme 29.09 21.59 17 4977 15684 64478054
Disseminated intravascular coagulation 28.35 21.59 22 4972 32326 64461412
Drug ineffective 28.30 21.59 15 4979 840232 63653506
Decreased appetite 26.95 21.59 64 4930 281225 64212513
Malignant neoplasm progression 26.68 21.59 38 4956 112833 64380905
Gastric cancer 23.46 21.59 11 4983 6482 64487256
C-reactive protein increased 22.49 21.59 32 4962 94877 64398861
Gamma-glutamyltransferase increased 22.47 21.59 23 4971 48487 64445251

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D005765 Gastrointestinal Agents
CHEBI has role CHEBI:49201 anti-ulcer drugs
CHEBI has role CHEBI:62868 hepatoprotective agents
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:76595 nephroprotective agents
CHEBI has role CHEBI:77307 cardioprotective agents
CHEBI has role CHEBI:78606 heat shock protein 70 inducers

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01827 KEGG_DRUG
3796-63-2 SECONDARY_CAS_RN
C0061231 UMLSCUI
CHEBI:31649 CHEBI
CHEMBL79686 ChEMBL_ID
CHEMBL3989432 ChEMBL_ID
DB15955 DRUGBANK_ID
C031049 MESH_SUPPLEMENTAL_RECORD_UI
5282199 PUBCHEM_CID
5412 INN_ID
S8S8451A4O UNII
1362746 RXNORM

Pharmaceutical products:

None