atorvastatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperlipidaemic substances, HMG CoA reductase inhibitors 257 134523-00-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • CI-981
  • CI981
  • atorvastatin calcium hydrate
  • atorvastatin calcium anhydrous
  • atorvastatin
  • atorvastatin acid
  • cardyl
  • atorvastatin calcium
  • atorvastatin calcium trihydrate
A pyrrole and heptanoic acid derivative, HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITOR (statin), and ANTICHOLESTEREMIC AGENT that is used to reduce serum levels of LDL-CHOLESTEROL; APOLIPOPROTEIN B; and TRIGLYCERIDES. It is used to increase serum levels of HDL-CHOLESTEROL in the treatment of HYPERLIPIDEMIAS, and for the prevention of CARDIOVASCULAR DISEASES in patients with multiple risk factors.
  • Molecular weight: 558.65
  • Formula: C33H35FN2O5
  • CLOGP: 4.46
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 4
  • TPSA: 111.79
  • ALOGS: -5.95
  • ROTB: 12
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.05 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ
S (Water solubility) 0.02 mg/mL Hosey CM, Chan R, Benet LZ
EoM (Fraction excreted unchanged in urine) 1 % Hosey CM, Chan R, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Dec. 17, 1996 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 1222.57 9.95 2594 346120 129431 55813922
Maternal exposure during pregnancy 965.08 9.95 51 348663 189502 55753851
Pemphigus 914.90 9.95 11 348703 157201 55786152
Rhabdomyolysis 876.96 9.95 1168 347546 39490 55903863
Rheumatoid arthritis 810.67 9.95 708 348006 381896 55561457
Immune-mediated myositis 774.62 9.95 288 348426 904 55942449
Systemic lupus erythematosus 733.89 9.95 118 348596 179960 55763393
Hand deformity 717.93 9.95 26 348688 134466 55808887
Glossodynia 711.98 9.95 63 348651 152395 55790958
Drug ineffective 663.77 9.95 3191 345523 915798 55027555
Contraindicated product administered 637.20 9.95 182 348532 186104 55757249
Exposure during pregnancy 601.14 9.95 70 348644 136272 55807081
Anti-cyclic citrullinated peptide antibody positive 587.22 9.95 4 348710 98596 55844757
Acute kidney injury 580.80 9.95 2985 345729 237778 55705575
Synovitis 558.28 9.95 154 348560 161151 55782202
Cerebrovascular accident 489.89 9.95 1540 347174 97730 55845623
Treatment failure 482.20 9.95 226 348488 170166 55773187
Pericarditis 479.92 9.95 56 348658 108867 55834486
Therapeutic product effect decreased 457.98 9.95 239 348475 169213 55774140
Wound 453.93 9.95 147 348567 138657 55804696
Myocardial infarction 432.99 9.95 1413 347301 91457 55851896
Infusion related reaction 431.64 9.95 395 348319 208536 55734817
Myopathy 427.87 9.95 407 348307 9405 55933948
Rheumatoid factor positive 400.82 9.95 5 348709 69055 55874298
Blood creatine phosphokinase increased 380.65 9.95 648 348066 27304 55916049
Off label use 371.69 9.95 1980 346734 554200 55389153
Arthropathy 367.79 9.95 419 348295 199856 55743497
Duodenal ulcer perforation 358.50 9.95 15 348699 68327 55875026
Drug intolerance 350.74 9.95 694 348020 264124 55679229
Discomfort 332.66 9.95 236 348478 141525 55801828
Alopecia 320.03 9.95 854 347860 292604 55650749
Swelling 315.18 9.95 631 348083 239140 55704213
Helicobacter infection 296.04 9.95 49 348665 73219 55870134
Abdominal discomfort 293.23 9.95 819 347895 276455 55666898
Muscular weakness 290.60 9.95 1350 347364 103102 55840251
Product use issue 289.53 9.95 440 348274 185601 55757752
Hypersensitivity 284.19 9.95 740 347974 255668 55687685
Acute myocardial infarction 273.56 9.95 591 348123 29802 55913551
Folliculitis 266.89 9.95 19 348695 54960 55888393
Drug interaction 257.42 9.95 2197 346517 207558 55735795
Completed suicide 240.16 9.95 285 348429 133548 55809805
Joint swelling 239.11 9.95 954 347760 288846 55654507
Necrotising myositis 235.10 9.95 92 348622 345 55943008
Coronary artery disease 230.78 9.95 557 348157 30239 55913114
Pain 229.22 9.95 2821 345893 660363 55282990
Drug hypersensitivity 211.88 9.95 2620 346094 272585 55670768
Hypomagnesaemia 211.06 9.95 474 348240 24541 55918812
Fall 210.44 9.95 3244 345470 354266 55589087
Sleep disorder due to general medical condition, insomnia type 210.29 9.95 15 348699 43323 55900030
Irritable bowel syndrome 202.63 9.95 85 348629 68373 55874980
Muscle spasms 202.41 9.95 1501 347213 135870 55807483
Impaired healing 184.15 9.95 160 348554 86681 55856672
Stomatitis 178.12 9.95 296 348418 120514 55822839
Muscle injury 178 9.95 52 348662 52448 55890905
Lactic acidosis 176.61 9.95 551 348163 34795 55908558
Hepatic enzyme increased 170.94 9.95 520 348194 170864 55772489
Hyponatraemia 166.64 9.95 1144 347570 100995 55842358
Blood glucose increased 165.08 9.95 909 347805 74242 55869111
Rash 164.43 9.95 2112 346602 490935 55452418
Hypoglycaemia 163.00 9.95 732 347982 55083 55888270
Hyperkalaemia 153.00 9.95 673 348041 50192 55893161
Polymyositis 144.93 9.95 106 348608 1674 55941679
Infection 143.73 9.95 694 348020 199512 55743841
Pregnancy 142.93 9.95 18 348696 33015 55910338
Toxicity to various agents 142.45 9.95 812 347902 223752 55719601
Transient ischaemic attack 141.43 9.95 494 348220 33083 55910270
Swollen joint count increased 135.11 9.95 3 348711 24181 55919172
Hemiplegia 133.59 9.95 209 348505 8195 55935158
Atrial fibrillation 133.56 9.95 1141 347573 107756 55835597
Abortion spontaneous 133.25 9.95 52 348662 43701 55899652
Cholestasis 133.02 9.95 418 348296 26495 55916858
Rheumatic fever 131.55 9.95 13 348701 28814 55914539
Chest pain 131.15 9.95 1772 346942 188025 55755328
Angina pectoris 130.54 9.95 426 348288 27550 55915803
Foetal exposure during pregnancy 129.32 9.95 26 348688 33797 55909556
Cardiac failure congestive 124.32 9.95 950 347764 86770 55856583
Asthenia 123.99 9.95 2888 345826 340085 55603268
Device expulsion 123.78 9.95 20 348694 30429 55912924
Febrile neutropenia 122.64 9.95 297 348417 105248 55838105
Low density lipoprotein increased 122.36 9.95 166 348548 5708 55937645
Ill-defined disorder 120.73 9.95 148 348566 68395 55874958
Drug abuse 119.07 9.95 146 348568 67464 55875889
Intentional product use issue 117.98 9.95 278 348436 99455 55843898
Ischaemic stroke 113.93 9.95 293 348421 16549 55926804
Sinusitis 112.44 9.95 739 347975 196842 55746511
Autoimmune hepatitis 112.28 9.95 187 348527 7734 55935619
Blister 110.21 9.95 328 348386 108559 55834794
Neurologic neglect syndrome 109.05 9.95 98 348616 2100 55941253
Hypertensive emergency 106.97 9.95 85 348629 1528 55941825
Psoriatic arthropathy 106.59 9.95 184 348530 73824 55869529
Carotid artery thrombosis 105.36 9.95 97 348617 2147 55941206
Syncope 105.24 9.95 1079 347635 107120 55836233
Liver function test abnormal 104.02 9.95 558 348156 45113 55898240
Diabetic ketoacidosis 102.53 9.95 303 348411 18568 55924785
Gastrointestinal haemorrhage 102.33 9.95 813 347901 75138 55868215
Dizziness 98.51 9.95 3037 345677 373103 55570250
Anaemia 97.63 9.95 2256 346458 265255 55678098
Renal failure 97.23 9.95 1080 347634 109420 55833933
Angina unstable 96.64 9.95 161 348553 6660 55936693
Myositis 95.65 9.95 181 348533 8287 55935066
Premature delivery 95.09 9.95 25 348689 27035 55916318
Melaena 92.54 9.95 384 348330 27906 55915447
Macular degeneration 91.91 9.95 292 348422 18616 55924737
Live birth 91.71 9.95 8 348706 19597 55923756
Condition aggravated 90.24 9.95 1548 347166 343350 55600003
Coronary artery occlusion 89.54 9.95 167 348547 7562 55935791
Gastrointestinal disorder 89.00 9.95 377 348337 112325 55831028
Hepatocellular injury 86.81 9.95 360 348354 26154 55917199
C-reactive protein increased 84.78 9.95 230 348484 78454 55864899
Hip arthroplasty 84.50 9.95 69 348645 38554 55904799
Drug-induced liver injury 83.25 9.95 428 348286 34034 55909319
Adjustment disorder 82.15 9.95 86 348628 2237 55941116
Intentional overdose 82.05 9.95 188 348526 67929 55875424
Bradycardia 82.04 9.95 706 348008 66798 55876555
Premature baby 81.80 9.95 11 348703 19194 55924159
Pyrexia 81.70 9.95 1973 346741 416800 55526553
Hepatitis cholestatic 81.17 9.95 144 348570 6270 55937083
Caesarean section 79.73 9.95 5 348709 16086 55927267
Malignant neoplasm progression 79.36 9.95 215 348499 73372 55869981
Myocardial ischaemia 78.08 9.95 207 348507 11909 55931444
Rectal haemorrhage 77.67 9.95 481 348233 40986 55902367
Glycosylated haemoglobin increased 77.35 9.95 196 348518 10969 55932384
Product use in unapproved indication 75.45 9.95 536 348178 140286 55803067
Cerebral haemorrhage 75.28 9.95 364 348350 28242 55915111
Dysarthria 74.85 9.95 460 348254 39090 55904263
Neutropenia 73.53 9.95 626 348088 157541 55785812
Renal impairment 72.87 9.95 793 347921 79920 55863433
Labelled drug-drug interaction medication error 72.70 9.95 196 348518 11390 55931963
Acute coronary syndrome 72.44 9.95 176 348538 9592 55933761
Knee arthroplasty 71.36 9.95 102 348612 44157 55899196
Coronary artery stenosis 70.86 9.95 111 348603 4357 55938996
Mixed liver injury 69.64 9.95 103 348611 3841 55939512
Jaundice 69.46 9.95 344 348370 26950 55916403
Cardiac failure 69.31 9.95 796 347918 81297 55862056
Personality disorder 69.18 9.95 119 348595 5054 55938299
Pancreatitis acute 68.51 9.95 323 348391 24801 55918552
Haematochezia 68.49 9.95 485 348229 43233 55900120
Diabetes mellitus 67.50 9.95 558 348156 52177 55891176
Lower respiratory tract infection 66.44 9.95 427 348287 114367 55828986
Nasopharyngitis 66.00 9.95 967 347747 219992 55723361
Cardiac disorder 64.44 9.95 496 348218 45391 55897962
Musculoskeletal stiffness 64.06 9.95 637 348077 155370 55787983
Atrioventricular block 63.19 9.95 135 348579 6752 55936601
Pemphigoid 63.07 9.95 128 348586 6172 55937181
Decreased appetite 62.65 9.95 1790 346924 217441 55725912
Diabetes mellitus inadequate control 62.64 9.95 210 348504 13770 55929583
Dehydration 62.11 9.95 1353 347361 157472 55785881
Intentional self-injury 62.07 9.95 39 348675 24953 55918400
Chromaturia 61.55 9.95 222 348492 15103 55928250
Blood triglycerides increased 61.08 9.95 185 348529 11492 55931861
International normalised ratio increased 60.71 9.95 474 348240 43567 55899786
Bone erosion 60.50 9.95 10 348704 14964 55928389
Hepatitis acute 60.30 9.95 149 348565 8208 55935145
Pain in extremity 59.80 9.95 2330 346384 295101 55648252
Chronic kidney disease 58.73 9.95 454 348260 41602 55901751
Hyperlipidaemia 57.81 9.95 244 348470 17865 55925488
Incorrect dosage administered 57.51 9.95 63 348651 1728 55941625
Hemiparesis 56.94 9.95 274 348440 21216 55922137
Polymyalgia rheumatica 56.61 9.95 82 348632 3000 55940353
Fibromyalgia 56.43 9.95 185 348529 59418 55883935
Blood pressure increased 54.94 9.95 1231 347483 143945 55799408
Atrioventricular block complete 54.48 9.95 134 348580 7360 55935993
Dyspnoea 53.10 9.95 4309 344405 588268 55355085
Injection site reaction 51.99 9.95 163 348551 53084 55890269
Oedema peripheral 51.91 9.95 1409 347305 169845 55773508
Swollen tongue 51.40 9.95 343 348371 29981 55913372
Myelosuppression 51.11 9.95 22 348692 17433 55925920
Autoimmune myositis 51.11 9.95 20 348694 75 55943278
Hepatitis 50.27 9.95 384 348330 35057 55908296
Gastrointestinal toxicity 50.08 9.95 115 348599 6041 55937312
Sensory loss 50.01 9.95 145 348569 8790 55934563
Motor dysfunction 49.62 9.95 150 348564 9307 55934046
Weight decreased 49.60 9.95 1891 346823 238823 55704530
Hyperglycaemia 49.49 9.95 406 348308 37875 55905478
Carotid artery stenosis 49.44 9.95 100 348614 4810 55938543
Neurotoxicity 49.38 9.95 18 348696 15777 55927576
Mobility decreased 49.09 9.95 385 348329 98606 55844747
Carotid arteriosclerosis 48.46 9.95 44 348670 956 55942397
Haematoma 47.72 9.95 351 348363 31668 55911685
Chronic obstructive pulmonary disease 47.68 9.95 555 348159 56860 55886493
Aphasia 47.39 9.95 337 348377 30078 55913275
Suicide attempt 47.17 9.95 191 348523 57645 55885708
Labile blood pressure 46.63 9.95 55 348659 1638 55941715
Red blood cell sedimentation rate abnormal 46.56 9.95 29 348685 18644 55924709
Injection site erythema 46.39 9.95 285 348429 77163 55866190
Dementia 46.35 9.95 220 348494 16938 55926415
Therapeutic drug monitoring analysis not performed 46.33 9.95 43 348671 962 55942391
Premature labour 45.70 9.95 9 348705 11873 55931480
Haemorrhage intracranial 45.59 9.95 178 348536 12577 55930776
Eosinophilia 45.50 9.95 245 348469 19832 55923521
Cytomegalovirus infection 45.37 9.95 32 348682 19264 55924089
Drug resistance 44.56 9.95 37 348677 20505 55922848
Blood alkaline phosphatase increased 44.55 9.95 402 348312 38543 55904810
Blood glucose decreased 43.99 9.95 234 348480 18853 55924500
Hypocalcaemia 43.85 9.95 317 348397 28443 55914910
Blood cholesterol abnormal 43.73 9.95 65 348649 2435 55940918
Amnesia 43.60 9.95 459 348255 45863 55897490
Lichen planopilaris 43.22 9.95 15 348699 36 55943317
Blood loss anaemia 42.97 9.95 131 348583 8166 55935187
Leukopenia 42.00 9.95 262 348452 70678 55872675
Cholestatic liver injury 41.48 9.95 60 348654 2192 55941161
Therapeutic response decreased 41.31 9.95 177 348537 52581 55890772
Urinary tract discomfort 41.24 9.95 26 348688 317 55943036
Large intestine polyp 40.99 9.95 122 348592 7505 55935848
Device dislocation 40.66 9.95 48 348666 22558 55920795
Product monitoring error 40.39 9.95 75 348639 3384 55939969
Muscle necrosis 40.38 9.95 32 348682 573 55942780
Eating disorder 40.31 9.95 211 348503 16894 55926459
Muscle atrophy 39.60 9.95 109 348605 6412 55936941
Vascular stent stenosis 39.56 9.95 30 348684 502 55942851
Gait disturbance 39.54 9.95 1307 347407 162014 55781339
Haematemesis 39.35 9.95 309 348405 28449 55914904
Infective pulmonary exacerbation of cystic fibrosis 39.06 9.95 3 348711 8154 55935199
Hypokalaemia 38.99 9.95 811 347903 93626 55849727
Panniculitis 38.82 9.95 7 348707 9835 55933518
Hepatitis toxic 38.29 9.95 67 348647 2885 55940468
Pre-eclampsia 38.27 9.95 4 348710 8482 55934871
Injection site swelling 38.05 9.95 140 348574 43438 55899915
Subdural haematoma 37.87 9.95 175 348539 13324 55930029
Mucosal inflammation 37.08 9.95 138 348576 42672 55900681
Gamma-glutamyltransferase increased 36.99 9.95 323 348391 30682 55912671
Low density lipoprotein abnormal 36.81 9.95 19 348695 153 55943200
Affect lability 36.76 9.95 142 348572 9983 55933370
Pulmonary toxicity 36.73 9.95 120 348594 7763 55935590
Product substitution issue 36.43 9.95 183 348531 14416 55928937
Tenosynovitis 36.02 9.95 16 348698 12445 55930908
Upper gastrointestinal haemorrhage 35.90 9.95 204 348510 16850 55926503
Euglycaemic diabetic ketoacidosis 35.81 9.95 68 348646 3121 55940232
Cerebral infarction 35.44 9.95 250 348464 22255 55921098
Mitral valve incompetence 34.89 9.95 212 348502 17941 55925412
Accidental exposure to product 34.82 9.95 62 348652 24585 55918768
Arteriosclerosis 34.67 9.95 133 348581 9320 55934033
Body height decreased 34.32 9.95 130 348584 9055 55934298
Intestinal haemorrhage 34.26 9.95 71 348643 3475 55939878
Anuria 34.14 9.95 154 348560 11606 55931747
Abortion induced 33.72 9.95 9 348705 9636 55933717
Incorrect route of product administration 33.55 9.95 50 348664 21279 55922074
Myopathy toxic 33.26 9.95 26 348688 456 55942897
Rectal polyp 33.20 9.95 38 348676 1095 55942258
Rheumatoid nodule 33.18 9.95 26 348688 14831 55928522
Migraine 32.91 9.95 361 348353 86436 55856917
Respiratory depression 32.87 9.95 18 348696 12417 55930936
Ischaemic cardiomyopathy 32.60 9.95 55 348659 2299 55941054
Pancytopenia 32.44 9.95 372 348342 88343 55855010
Injection site pain 32.39 9.95 520 348194 116598 55826755
Flatulence 32.31 9.95 316 348398 30972 55912381
Blood creatine phosphokinase MB increased 32.24 9.95 38 348676 1131 55942222
Urinary tract infection 32.11 9.95 1809 346905 238704 55704649
Dysuria 32.05 9.95 311 348403 30418 55912935
Inappropriate antidiuretic hormone secretion 31.94 9.95 169 348545 13587 55929766
Peripheral artery stenosis 31.92 9.95 27 348687 532 55942821
Coma 31.47 9.95 228 348486 59427 55883926
Diabetic metabolic decompensation 31.11 9.95 43 348671 1505 55941848
Product prescribing error 31.10 9.95 248 348466 22938 55920415
Graft versus host disease 31.09 9.95 3 348711 6778 55936575
Grip strength decreased 30.89 9.95 33 348681 16223 55927130
Muscle disorder 30.83 9.95 80 348634 4543 55938810
Myoglobin blood increased 30.64 9.95 40 348674 1324 55942029
Arthralgia 30.55 9.95 2684 346030 498985 55444368
Arterial occlusive disease 30.47 9.95 88 348626 5322 55938031
Cerebral haematoma 30.33 9.95 65 348649 3258 55940095
Dysphagia 30.08 9.95 692 348022 81255 55862098
Head injury 29.83 9.95 261 348453 24805 55918548
High density lipoprotein decreased 29.66 9.95 45 348669 1717 55941636
Adverse event 29.52 9.95 211 348503 55165 55888188
Mouth swelling 29.51 9.95 73 348641 4024 55939329
Dysgeusia 29.43 9.95 385 348329 40530 55902823
Aortic stenosis 29.42 9.95 76 348638 4304 55939049
Enthesopathy 29.20 9.95 7 348707 8056 55935297
Diabetic retinopathy 29.11 9.95 51 348663 2198 55941155
Hepatic function abnormal 29.11 9.95 335 348379 34223 55909130
Myocardial necrosis marker increased 28.79 9.95 44 348670 1690 55941663
Loss of personal independence in daily activities 28.67 9.95 344 348370 81025 55862328
Coordination abnormal 28.59 9.95 154 348560 12467 55930886
Disease progression 28.41 9.95 469 348245 104704 55838649
Foetal death 28.21 9.95 9 348705 8578 55934775
Malaise 28.16 9.95 2645 346069 365215 55578138
Adverse drug reaction 27.95 9.95 263 348451 64869 55878484
Hypovolaemia 27.90 9.95 127 348587 9608 55933745
Presyncope 27.71 9.95 261 348453 25321 55918032
Renal disorder 27.69 9.95 293 348421 29312 55914041
Therapeutic product effect incomplete 27.60 9.95 476 348238 105555 55837798
Neutrophil count decreased 27.46 9.95 188 348526 49634 55893719
Febrile bone marrow aplasia 27.43 9.95 4 348710 6568 55936785
Alveolar osteitis 27.28 9.95 25 348689 550 55942803
Uterine perforation 27.06 9.95 4 348710 6501 55936852
Injury 26.84 9.95 239 348475 59612 55883741
Aldolase increased 26.75 9.95 15 348699 145 55943208
Oligohydramnios 26.59 9.95 3 348711 5991 55937362
Angiopathy 26.55 9.95 72 348642 4198 55939155
Acute myeloid leukaemia 26.49 9.95 40 348674 16932 55926421
Ear congestion 26.46 9.95 48 348666 2127 55941226
Embolic stroke 26.45 9.95 65 348649 3568 55939785
Joint range of motion decreased 25.94 9.95 76 348638 25289 55918064
Hepatic ischaemia 25.74 9.95 25 348689 593 55942760
Faeces discoloured 25.71 9.95 187 348527 16809 55926544
Duodenal ulcer 25.69 9.95 100 348614 7055 55936298
Glomerular filtration rate decreased 25.64 9.95 147 348567 12182 55931171
Red blood cell sedimentation rate increased 25.62 9.95 128 348586 36495 55906858
Cell death 25.49 9.95 49 348665 2270 55941083
Stillbirth 25.44 9.95 4 348710 6210 55937143
Ankylosing spondylitis 25.35 9.95 15 348699 9915 55933438
Amenorrhoea 25.26 9.95 12 348702 8974 55934379
Lip swelling 25.04 9.95 261 348453 26011 55917342
Traumatic coma 24.70 9.95 11 348703 61 55943292
Dyslipidaemia 24.64 9.95 91 348623 6262 55937091
Respiratory arrest 24.43 9.95 102 348612 30523 55912830
Haematuria 24.27 9.95 265 348449 26722 55916631
Stent placement 24.25 9.95 62 348652 3489 55939864
Angioedema 24.19 9.95 376 348338 41077 55902276
Post viral fatigue syndrome 24.15 9.95 18 348696 293 55943060
Poisoning deliberate 24.08 9.95 16 348698 9937 55933416
Alanine aminotransferase increased 23.80 9.95 754 347960 92908 55850445
Carotid artery occlusion 23.59 9.95 51 348663 2572 55940781
Inflammation 23.58 9.95 294 348420 68777 55874576
Spinal epidural haematoma 23.52 9.95 31 348683 1036 55942317
Hypovolaemic shock 23.44 9.95 80 348634 5293 55938060
Hypertensive cardiomyopathy 23.44 9.95 15 348699 188 55943165
Cardiotoxicity 23.44 9.95 9 348705 7641 55935712
Dermatomyositis 23.43 9.95 52 348662 2670 55940683
Subarachnoid haemorrhage 23.40 9.95 135 348579 11212 55932141
Epistaxis 23.38 9.95 562 348152 66461 55876892
Pollakiuria 23.37 9.95 249 348465 24953 55918400
Metastases to bone 23.35 9.95 54 348660 19454 55923899
Eructation 23.26 9.95 101 348613 7487 55935866
Thyroid disorder 23.22 9.95 157 348557 13781 55929572
Pallor 23.06 9.95 240 348474 23909 55919444
Creatinine renal clearance decreased 23.03 9.95 34 348680 14525 55928828
Dyspnoea exertional 23.00 9.95 471 348243 54218 55889135
Food allergy 22.99 9.95 13 348701 8811 55934542
Confusional state 22.99 9.95 1540 347174 206615 55736738
Haemorrhagic transformation stroke 22.94 9.95 32 348682 1130 55942223
Hepatic steatosis 22.93 9.95 256 348458 25958 55917395
Retinal artery occlusion 22.73 9.95 37 348677 1501 55941852
Device issue 22.49 9.95 62 348652 21044 55922309
Back pain 22.48 9.95 1733 346981 235437 55707916
Tunnel vision 22.48 9.95 27 348687 820 55942533
Hypotension 22.37 9.95 1822 346892 248686 55694667
Urinary tract obstruction 22.33 9.95 41 348673 1834 55941519
Hypoacusis 22.06 9.95 219 348495 21549 55921804
Polyuria 22.01 9.95 99 348615 7452 55935901
Blood creatine phosphokinase abnormal 21.97 9.95 15 348699 211 55943142
Sedation complication 21.84 9.95 24 348690 11648 55931705
Blood creatinine increased 21.83 9.95 651 348063 79540 55863813
Cardiac murmur 21.81 9.95 133 348581 11268 55932085
Electrocardiogram abnormal 21.69 9.95 104 348610 8040 55935313
Electrocardiogram QT prolonged 21.62 9.95 466 348248 54122 55889231
Interstitial lung disease 21.60 9.95 484 348230 56579 55886774
Arterial stenosis 21.59 9.95 22 348692 554 55942799
Sedation 21.53 9.95 127 348587 34727 55908626
Blood iron decreased 21.50 9.95 143 348571 12484 55930869
Maternal drugs affecting foetus 21.49 9.95 3 348711 5090 55938263
Blood pressure systolic increased 21.44 9.95 364 348350 40472 55902881
Urine output decreased 21.44 9.95 127 348587 10650 55932703
Antimitochondrial antibody positive 21.41 9.95 10 348704 63 55943290
Blood urea increased 21.41 9.95 239 348475 24234 55919119
Blood sodium decreased 21.34 9.95 222 348492 22112 55921241
Vertigo 21.33 9.95 465 348249 54107 55889246
Coronary artery thrombosis 21.32 9.95 30 348684 1068 55942285
Joint destruction 21.28 9.95 3 348711 5052 55938301
Aspartate aminotransferase increased 21.26 9.95 666 348048 81936 55861417
Weight increased 21.19 9.95 1185 347529 228518 55714835
Musculoskeletal chest pain 21.08 9.95 200 348514 19441 55923912
Haemophagocytic lymphohistiocytosis 21.06 9.95 17 348697 9555 55933798
Fibromatosis colli of infancy 21.03 9.95 7 348707 14 55943339
Acquired plagiocephaly 21.03 9.95 7 348707 14 55943339
Gastric ulcer 20.96 9.95 223 348491 22340 55921013
Ketoacidosis 20.79 9.95 64 348650 4011 55939342
Myoglobinuria 20.74 9.95 16 348698 275 55943078
Dysstasia 20.73 9.95 197 348517 19157 55924196
Hepatic cytolysis 20.72 9.95 127 348587 10779 55932574
Hepatorenal syndrome 20.68 9.95 39 348675 1781 55941572
Device related infection 20.64 9.95 68 348646 21812 55921541
Complication of device insertion 20.63 9.95 7 348707 6417 55936936
Pancreatitis 20.55 9.95 393 348321 44687 55898666
Unintentional medical device removal 20.51 9.95 5 348709 5689 55937664
Balance disorder 20.50 9.95 620 348094 75900 55867453
Diverticulum 20.49 9.95 128 348586 10938 55932415
Metastases to liver 20.43 9.95 67 348647 21519 55921834
Psychotic disorder 20.36 9.95 76 348638 23482 55919871
Cervix neoplasm 20.27 9.95 14 348700 201 55943152
Blood cholesterol increased 20.24 9.95 591 348123 71988 55871365
Pathogen resistance 20.23 9.95 6 348708 5994 55937359
Chest discomfort 20.17 9.95 776 347938 98081 55845272
Candida infection 20.16 9.95 86 348628 25581 55917772
Diarrhoea 20.07 9.95 4358 344356 634149 55309204
Chloropsia 20.05 9.95 8 348706 32 55943321
Diverticulum intestinal 19.96 9.95 86 348628 6354 55936999
Liver disorder 19.95 9.95 386 348328 43984 55899369
Immunodeficiency 19.93 9.95 44 348670 16113 55927240
Pulmonary renal syndrome 19.90 9.95 18 348696 389 55942964
Hypertensive crisis 19.86 9.95 152 348562 13884 55929469
Coronary artery restenosis 19.84 9.95 17 348697 341 55943012
Coronary artery bypass 19.82 9.95 44 348670 2259 55941094
Ocular myasthenia 19.78 9.95 12 348702 136 55943217
Juvenile idiopathic arthritis 19.70 9.95 3 348711 4770 55938583
Haematotoxicity 19.58 9.95 14 348700 8369 55934984
Peripheral nerve palsy 19.56 9.95 7 348707 19 55943334
Cystostomy 19.50 9.95 9 348705 55 55943298
Blood parathyroid hormone decreased 19.50 9.95 14 348700 8350 55935003
Memory impairment 19.49 9.95 687 348027 85870 55857483
Injection site pruritus 19.44 9.95 166 348548 41765 55901588
Onychomadesis 19.42 9.95 3 348711 4718 55938635
Cardiac failure acute 19.24 9.95 107 348607 8766 55934587
Left atrial enlargement 19.24 9.95 15 348699 262 55943091
Tuberculosis 19.22 9.95 24 348690 11005 55932348
Electrocardiogram Q wave abnormal 19.20 9.95 12 348702 144 55943209
Cataract 19.19 9.95 434 348280 50813 55892540
Sinus bradycardia 19.15 9.95 147 348567 13439 55929914
Disorientation 19.09 9.95 326 348388 36287 55907066
Maternal exposure timing unspecified 19.07 9.95 5 348709 5418 55937935
Diabetic nephropathy 19.06 9.95 32 348682 1332 55942021
Arteriovenous fistula occlusion 19.00 9.95 17 348697 362 55942991
Albuminuria 18.86 9.95 13 348701 186 55943167
Abnormal loss of weight 18.85 9.95 74 348640 5242 55938111
Lipids abnormal 18.72 9.95 15 348699 273 55943080
High density lipoprotein abnormal 18.72 9.95 10 348704 87 55943266
Palpitations 18.62 9.95 775 347939 98897 55844456
Calcium deficiency 18.59 9.95 27 348687 990 55942363
Ventricular hypertrophy 18.56 9.95 53 348661 3185 55940168
Acidosis 18.53 9.95 120 348594 10381 55932972
Periorbital haematoma 18.53 9.95 23 348691 723 55942630
Heavy menstrual bleeding 18.51 9.95 46 348668 16163 55927190
Hypophagia 18.44 9.95 266 348448 28610 55914743
Acne 18.39 9.95 68 348646 21068 55922285
Breast cancer metastatic 18.37 9.95 43 348671 15426 55927927
Hallucination, gustatory 18.37 9.95 9 348705 64 55943289
Transaminases increased 18.36 9.95 265 348449 28505 55914848
Mydriasis 18.36 9.95 25 348689 11046 55932307
Poisoning 18.31 9.95 32 348682 12781 55930572
Peripheral arterial occlusive disease 18.29 9.95 59 348655 3791 55939562
Deformity 18.20 9.95 22 348692 10233 55933120
Subacute cutaneous lupus erythematosus 18.14 9.95 43 348671 2306 55941047
Aspergillus infection 18.06 9.95 12 348702 7453 55935900
Epstein-Barr virus infection 18.05 9.95 12 348702 7451 55935902
Device adhesion issue 18.05 9.95 3 348711 4471 55938882
Transplant rejection 17.96 9.95 21 348693 9913 55933440
Tongue oedema 17.91 9.95 60 348654 3932 55939421
Hypertransaminasaemia 17.90 9.95 67 348647 4640 55938713
Vascular stent occlusion 17.87 9.95 8 348706 45 55943308
Muscle relaxant therapy 17.81 9.95 12 348702 165 55943188
Nausea 17.69 9.95 5146 343568 759032 55184321
Intermittent claudication 17.62 9.95 36 348678 1744 55941609
Electrolyte imbalance 17.59 9.95 180 348534 17853 55925500
Abnormal dreams 17.48 9.95 111 348603 9538 55933815
Suicidal ideation 17.45 9.95 252 348462 57490 55885863
Feeling abnormal 17.44 9.95 1003 347711 132599 55810754
Adjustment disorder with depressed mood 17.39 9.95 5 348709 5098 55938255
Seizure 17.38 9.95 617 348097 124502 55818851
Large intestinal haemorrhage 17.36 9.95 29 348685 1202 55942151
Neurosensory hypoacusis 17.32 9.95 13 348701 214 55943139
Multiple sclerosis relapse 17.32 9.95 186 348528 44717 55898636
Subchondral insufficiency fracture 17.32 9.95 8 348706 49 55943304
Skin haemorrhage 17.29 9.95 100 348614 8313 55935040
Dislocation of vertebra 17.22 9.95 6 348708 5409 55937944
Ligament sprain 17.21 9.95 126 348588 11349 55932004
Coronary artery surgery 17.18 9.95 8 348706 50 55943303
Oesophageal obstruction 17.05 9.95 18 348696 473 55942880
Menstrual disorder 17.04 9.95 4 348710 4671 55938682
Hypervolaemia 17 9.95 244 348470 26214 55917139
Bone marrow failure 16.98 9.95 104 348610 28182 55915171
Carotid artery disease 16.93 9.95 33 348681 1545 55941808
Blood pressure inadequately controlled 16.88 9.95 64 348650 4460 55938893
Hypercholesterolaemia 16.86 9.95 150 348564 14323 55929030
Intra-abdominal haematoma 16.74 9.95 34 348680 1640 55941713
Arterial insufficiency 16.72 9.95 11 348703 145 55943208
Metastases to central nervous system 16.72 9.95 31 348683 12105 55931248
Cerebral ischaemia 16.71 9.95 79 348635 6071 55937282
Fatigue 16.63 9.95 4490 344224 784062 55159291
Low birth weight baby 16.63 9.95 9 348705 6249 55937104
Spur cell anaemia 16.58 9.95 6 348708 17 55943336
Renal injury 16.58 9.95 103 348611 8784 55934569
Movement disorder 16.57 9.95 187 348527 19011 55924342
Overdose 16.56 9.95 514 348200 105316 55838037
Vascular device infection 16.44 9.95 7 348707 5583 55937770
Cholangiolitis 16.36 9.95 4 348710 0 55943353
Basal ganglia haemorrhage 16.34 9.95 19 348695 557 55942796
Blood electrolytes abnormal 16.34 9.95 25 348689 961 55942392
Ear infection 16.31 9.95 120 348594 31175 55912178
Rales 16.24 9.95 119 348595 10721 55932632
Hallucination 16.20 9.95 409 348305 48740 55894613
Device difficult to use 16.18 9.95 26 348688 10735 55932618
Urinary retention 16.13 9.95 254 348460 27820 55915533
Microcytic anaemia 16.06 9.95 50 348664 3152 55940201
Ageusia 16.06 9.95 132 348582 12319 55931034
Muscle fatigue 16.02 9.95 41 348673 2308 55941045
Aplastic anaemia 16.01 9.95 19 348695 8909 55934444
Lipoprotein (a) increased 15.99 9.95 7 348707 37 55943316
Menstruation irregular 15.86 9.95 10 348704 6386 55936967
Prothrombin consumption time prolonged 15.84 9.95 7 348707 38 55943315
Lower gastrointestinal haemorrhage 15.81 9.95 87 348627 7100 55936253
Blood potassium increased 15.75 9.95 170 348544 17091 55926262
Incision site haemorrhage 15.72 9.95 18 348696 519 55942834
Breast cancer stage II 15.71 9.95 8 348706 5750 55937603
Atrial flutter 15.71 9.95 104 348610 9065 55934288
Diabetic neuropathy 15.65 9.95 55 348659 3693 55939660
Tubulointerstitial nephritis 15.62 9.95 165 348549 16500 55926853
Cerebral microangiopathy 15.59 9.95 13 348701 251 55943102
Saliva altered 15.58 9.95 14 348700 300 55943053
Arteriosclerosis coronary artery 15.54 9.95 92 348622 7713 55935640
Blood lactic acid 15.46 9.95 9 348705 94 55943259
Hyperlactacidaemia 15.46 9.95 43 348671 2545 55940808
Flank pain 15.44 9.95 146 348568 14179 55929174
Blood cholesterol decreased 15.42 9.95 23 348691 864 55942489
Progressive multifocal leukoencephalopathy 15.41 9.95 32 348682 11981 55931372
Stevens-Johnson syndrome 15.40 9.95 80 348634 22583 55920770
Muscle enzyme increased 15.38 9.95 10 348704 129 55943224
International normalised ratio abnormal 15.31 9.95 47 348667 2941 55940412
X-ray abnormal 15.27 9.95 4 348710 4337 55939016
Macular oedema 15.27 9.95 55 348659 3739 55939614
Swelling face 15.21 9.95 455 348259 55614 55887739
Blood creatinine abnormal 15.19 9.95 45 348669 2761 55940592
Lymphocyte count decreased 15.11 9.95 106 348608 27833 55915520
Breast cancer stage I 15.09 9.95 10 348704 6220 55937133
Lipids increased 15 9.95 26 348688 1111 55942242
Orthostatic hypotension 14.99 9.95 289 348425 32910 55910443
Skin necrosis 14.97 9.95 34 348680 12327 55931026
Pulmonary oedema 14.96 9.95 419 348295 50724 55892629
Cardiac operation 14.92 9.95 46 348668 2885 55940468
Haemorrhagic cyst 14.87 9.95 11 348703 177 55943176
Bundle branch block left 14.66 9.95 78 348636 6284 55937069
Waist circumference increased 14.48 9.95 21 348693 769 55942584
Paradoxical drug reaction 14.47 9.95 3 348711 3817 55939536
Chest wall haematoma 14.46 9.95 11 348703 185 55943168
Parkinsonism 14.42 9.95 105 348609 9441 55933912
Tobacco abuse 14.37 9.95 19 348695 637 55942716
Injection site warmth 14.33 9.95 43 348671 14200 55929153
Joint injury 14.33 9.95 231 348483 25423 55917930
Blue toe syndrome 14.27 9.95 15 348699 392 55942961
Ventricular septal defect 14.20 9.95 4 348710 4134 55939219
Prolonged expiration 14.11 9.95 22 348692 860 55942493
Cardiac discomfort 14.09 9.95 22 348692 861 55942492
Renal tubular necrosis 14.08 9.95 115 348599 10713 55932640
Tumour lysis syndrome 14.06 9.95 17 348697 7906 55935447
Facial paralysis 14.02 9.95 135 348579 13176 55930177
Ecchymosis 14.01 9.95 111 348603 10245 55933108
Palmar-plantar erythrodysaesthesia syndrome 13.96 9.95 75 348639 20990 55922363
Colitis ischaemic 13.89 9.95 108 348606 9912 55933441
Eosinophilic fasciitis 13.88 9.95 10 348704 154 55943199
Bladder sphincter atony 13.83 9.95 10 348704 155 55943198
Hypocapnia 13.82 9.95 14 348700 350 55943003
Administration site discomfort 13.79 9.95 8 348706 83 55943270
Neutropenic sepsis 13.78 9.95 48 348666 15137 55928216
Cough 13.77 9.95 1825 346889 258136 55685217
Peripheral vascular disorder 13.75 9.95 71 348643 5654 55937699
Arrhythmia 13.73 9.95 299 348415 34784 55908569
Blood calcium increased 13.68 9.95 92 348622 8062 55935291
Jaundice cholestatic 13.64 9.95 69 348645 5450 55937903
Cardiac pacemaker insertion 13.63 9.95 53 348661 3737 55939616
Hypertensive angiopathy 13.62 9.95 8 348706 85 55943268
Copper metabolism disorder 13.61 9.95 4 348710 4 55943349
Vascular stenosis 13.61 9.95 13 348701 302 55943051
Serotonin syndrome 13.60 9.95 102 348612 26388 55916965
Sinus node dysfunction 13.58 9.95 59 348655 4375 55938978
Faeces pale 13.56 9.95 30 348684 1537 55941816
Jaundice hepatocellular 13.52 9.95 6 348708 33 55943320
Gouty arthritis 13.46 9.95 17 348697 544 55942809
Colitis ulcerative 13.46 9.95 92 348622 24299 55919054
N-terminal prohormone brain natriuretic peptide increased 13.46 9.95 33 348681 1809 55941544
Hyponatraemic seizure 13.45 9.95 15 348699 420 55942933
Schizophrenia 13.44 9.95 28 348686 10471 55932882
Eye haemorrhage 13.44 9.95 89 348625 7758 55935595
Cerebral mass effect 13.41 9.95 21 348693 824 55942529
Bronchopulmonary aspergillosis 13.36 9.95 19 348695 8245 55935108
Bladder pain 13.32 9.95 33 348681 1821 55941532
Product dose omission issue 13.29 9.95 1456 347258 203297 55740056
Multiple injuries 13.29 9.95 32 348682 1734 55941619
Multi-organ disorder 13.25 9.95 27 348687 1306 55942047
Ventricular internal diameter abnormal 13.23 9.95 6 348708 35 55943318
Polyarthritis 13.21 9.95 21 348693 8707 55934646
Urinary occult blood positive 13.19 9.95 7 348707 60 55943293
Bacteraemia 13.14 9.95 51 348663 15580 55927773
Muscle rupture 13.10 9.95 37 348677 2209 55941144
Cytokine release syndrome 13.10 9.95 30 348684 10845 55932508
Hypomania 13.10 9.95 7 348707 4895 55938458
Prevertebral soft tissue swelling of cervical space 13.09 9.95 6 348708 36 55943317
Wrong dose 13.08 9.95 23 348691 994 55942359
Heart sounds 13.03 9.95 20 348694 771 55942582
Gait deviation 13.00 9.95 7 348707 62 55943291
Nail bed inflammation 12.95 9.95 14 348700 378 55942975
Renovascular hypertension 12.93 9.95 5 348709 18 55943335
Cholelithiasis 12.89 9.95 328 348386 39136 55904217
Blood pressure decreased 12.88 9.95 467 348247 58583 55884770
Liver injury 12.87 9.95 182 348532 41666 55901687
Sinus disorder 12.84 9.95 190 348524 20544 55922809
Generalised tonic-clonic seizure 12.84 9.95 109 348605 27457 55915896
Xanthelasma 12.81 9.95 7 348707 64 55943289
Internal haemorrhage 12.80 9.95 61 348653 4703 55938650
Inclusion body myositis 12.73 9.95 4 348710 6 55943347
Parkinsonian rest tremor 12.73 9.95 8 348706 97 55943256
Myoglobinaemia 12.73 9.95 5 348709 19 55943334
Muscle haemorrhage 12.72 9.95 44 348670 2931 55940422
IIIrd nerve paresis 12.70 9.95 9 348705 135 55943218
Drug ineffective for unapproved indication 12.69 9.95 100 348614 25593 55917760
Low density lipoprotein decreased 12.66 9.95 11 348703 225 55943128
Iron deficiency anaemia 12.63 9.95 168 348546 17751 55925602
Injection site rash 12.60 9.95 58 348656 16900 55926453
Immune reconstitution inflammatory syndrome 12.58 9.95 10 348704 5664 55937689
Paresis 12.58 9.95 37 348677 2261 55941092
Acute left ventricular failure 12.58 9.95 22 348692 947 55942406
Exercise tolerance decreased 12.54 9.95 64 348650 5074 55938279
Mammogram abnormal 12.42 9.95 18 348696 659 55942694
Hypergammaglobulinaemia 12.40 9.95 15 348699 459 55942894
Cardiac failure chronic 12.36 9.95 54 348660 4013 55939340
Biliary fibrosis 12.36 9.95 4 348710 7 55943346
Eyelid retraction 12.33 9.95 6 348708 42 55943311
Diverticulum oesophageal 12.31 9.95 9 348705 142 55943211
Disability 12.31 9.95 53 348661 15727 55927626
Oral herpes 12.30 9.95 87 348627 22803 55920550
Blood magnesium decreased 12.29 9.95 120 348594 11754 55931599
Animal scratch 12.28 9.95 23 348691 1045 55942308
Adenovirus infection 12.26 9.95 3 348711 3405 55939948
Product complaint 12.25 9.95 119 348595 11641 55931712
Cardiac valve disease 12.21 9.95 53 348661 3928 55939425
Retroperitoneal haematoma 12.19 9.95 41 348673 2692 55940661
Neoplasm progression 12.19 9.95 133 348581 31883 55911470
Lipoma 12.19 9.95 36 348678 2205 55941148
Respiratory disorder 12.17 9.95 143 348571 33814 55909539
Diabetic foot 12.16 9.95 26 348688 1301 55942052
End stage renal disease 12.15 9.95 72 348642 6039 55937314
Nephrosclerosis 12.14 9.95 22 348692 974 55942379
Staphylococcal infection 12.14 9.95 162 348552 37456 55905897
Muscle contracture 12.13 9.95 25 348689 1219 55942134
Type V hyperlipidaemia 12.12 9.95 15 348699 470 55942883
Intracranial haematoma 12.12 9.95 13 348701 348 55943005
Gastric ulcer haemorrhage 12.09 9.95 59 348655 4594 55938759
Pneumocystis jirovecii pneumonia 12.09 9.95 53 348661 15648 55927705
Acute respiratory failure 12.08 9.95 264 348450 30730 55912623
Coeliac disease 12.07 9.95 29 348685 10310 55933043
Human herpesvirus 6 infection reactivation 12.05 9.95 9 348705 147 55943206
Sebaceous gland infection 12.05 9.95 9 348705 147 55943206
Lipohypertrophy 12.05 9.95 17 348697 607 55942746
Neuroglycopenia 12.03 9.95 14 348700 411 55942942
Post transplant lymphoproliferative disorder 12.01 9.95 7 348707 4665 55938688
Choluria 12.00 9.95 9 348705 148 55943205
Narrow anterior chamber angle 11.98 9.95 6 348708 45 55943308
Glucose urine present 11.98 9.95 18 348696 681 55942672
Urticaria 11.96 9.95 754 347960 143922 55799431
Dilatation atrial 11.96 9.95 32 348682 1851 55941502
Musculoskeletal pain 11.92 9.95 616 348098 80536 55862817
Genital haemorrhage 11.89 9.95 15 348699 6847 55936506
Anal polyp 11.87 9.95 6 348708 46 55943307
Crystal urine 11.87 9.95 6 348708 46 55943307
Vascular purpura 11.86 9.95 26 348688 1324 55942029
Gastroduodenal haemorrhage 11.79 9.95 7 348707 76 55943277
Cerebral artery stenosis 11.76 9.95 14 348700 421 55942932
Peripheral coldness 11.75 9.95 112 348602 10899 55932454
Cervicobrachial syndrome 11.75 9.95 20 348694 842 55942511
Lacunar stroke 11.75 9.95 8 348706 112 55943241
Neurofibrosarcoma 11.75 9.95 9 348705 153 55943200
Albumin urine present 11.75 9.95 11 348703 249 55943104
Hyperprolactinaemia 11.74 9.95 4 348710 3657 55939696
Metabolic acidosis 11.71 9.95 331 348383 40123 55903230
Posture abnormal 11.66 9.95 35 348679 2163 55941190
Blood calcitonin increased 11.65 9.95 5 348709 25 55943328
Haemorrhagic stroke 11.61 9.95 65 348649 5338 55938015
Soft tissue disorder 11.61 9.95 6 348708 4276 55939077
Lung hyperinflation 11.59 9.95 24 348690 1174 55942179
Nervousness 11.58 9.95 248 348466 28767 55914586
Device deployment issue 11.55 9.95 4 348710 3620 55939733
Fear of injection 11.54 9.95 14 348700 6501 55936852
Parapsoriasis 11.51 9.95 8 348706 116 55943237
Granulomatous dermatitis 11.51 9.95 8 348706 116 55943237
Lethargy 11.51 9.95 408 348306 51033 55892320
Gastritis 11.50 9.95 289 348425 34413 55908940
Carotid bruit 11.49 9.95 17 348697 634 55942719
Anisocytosis 11.49 9.95 17 348697 634 55942719
Lipase increased 11.48 9.95 95 348619 8884 55934469
Vascular graft 11.47 9.95 19 348695 782 55942571
Glomerular filtration rate abnormal 11.46 9.95 18 348696 708 55942645
Mitral valve disease 11.46 9.95 36 348678 2281 55941072
Myeloma cast nephropathy 11.46 9.95 8 348706 117 55943236
Neoplasm malignant 11.37 9.95 233 348481 26822 55916531
Aortic valve replacement 11.28 9.95 18 348696 718 55942635
Shock haemorrhagic 11.24 9.95 95 348619 8938 55934415
Depressed mood 11.24 9.95 300 348414 36059 55907294
Lymphomatoid papulosis 11.23 9.95 8 348706 121 55943232
Speech disorder 11.20 9.95 308 348406 37185 55906168
Bifascicular block 11.17 9.95 8 348706 122 55943231
Acute pulmonary oedema 11.16 9.95 83 348631 7514 55935839
Atrioventricular block first degree 11.15 9.95 76 348638 6689 55936664
Tenderness 11.13 9.95 76 348638 20079 55923274
Connective tissue inflammation 11.06 9.95 6 348708 54 55943299
Binocular eye movement disorder 11.05 9.95 5 348709 29 55943324
Fine motor skill dysfunction 11.04 9.95 7 348707 4458 55938895
Cardioactive drug level increased 11.03 9.95 33 348681 2036 55941317
Plasma cell myeloma 11.00 9.95 213 348501 46433 55896920
Percutaneous coronary intervention 10.99 9.95 10 348704 218 55943135
Gout 10.99 9.95 120 348594 12101 55931252
Product taste abnormal 10.91 9.95 31 348683 1857 55941496
Exercise tolerance increased 10.91 9.95 5 348709 30 55943323
Arterial disorder 10.90 9.95 23 348691 1140 55942213
Nasal obstruction 10.88 9.95 24 348690 1227 55942126
Cardiomyopathy 10.87 9.95 151 348563 16107 55927246
Cholecystitis chronic 10.87 9.95 28 348686 9720 55933633
Accelerated hypertension 10.84 9.95 13 348701 394 55942959
Primary biliary cholangitis 10.78 9.95 23 348691 1149 55942204
Haemoglobin decreased 10.76 9.95 968 347746 133169 55810184
Left ventricular hypertrophy 10.74 9.95 60 348654 4924 55938429
Tubulointerstitial nephritis and uveitis syndrome 10.73 9.95 10 348704 225 55943128
Dementia Alzheimer's type 10.72 9.95 22 348692 1069 55942284
Torsade de pointes 10.66 9.95 121 348593 12319 55931034
Ocular icterus 10.65 9.95 47 348667 3509 55939844
Therapy partial responder 10.62 9.95 20 348694 7765 55935588
Mixed anxiety and depressive disorder 10.62 9.95 10 348704 228 55943125
Acute cutaneous lupus erythematosus 10.60 9.95 11 348703 283 55943070
Colorectal cancer 10.56 9.95 4 348710 3425 55939928
Myelodysplastic syndrome 10.55 9.95 59 348655 16347 55927006
Furuncle 10.55 9.95 69 348645 5990 55937363
Noninfectious peritonitis 10.54 9.95 8 348706 134 55943219
Supraventricular extrasystoles 10.53 9.95 52 348662 4068 55939285
Alanine aminotransferase 10.53 9.95 6 348708 60 55943293
BRASH syndrome 10.51 9.95 11 348703 286 55943067
Drug tolerance 10.49 9.95 13 348701 5981 55937372
Malignant polyp 10.49 9.95 9 348705 181 55943172
Unintended pregnancy 10.48 9.95 10 348704 5181 55938172
Vaginal haemorrhage 10.45 9.95 105 348609 25568 55917785
Alpha hydroxybutyrate dehydrogenase increased 10.43 9.95 4 348710 14 55943339
Product administration error 10.43 9.95 185 348529 20744 55922609
Vascular graft occlusion 10.40 9.95 9 348705 183 55943170
Vitrectomy 10.39 9.95 8 348706 137 55943216
Scleritis 10.36 9.95 5 348709 3706 55939647
Cardio-respiratory arrest 10.36 9.95 262 348452 55059 55888294
Nightmare 10.35 9.95 154 348560 16672 55926681
Blood iron abnormal 10.30 9.95 4 348710 3373 55939980
Laryngotracheal oedema 10.27 9.95 5 348709 35 55943318
Ascites 10.27 9.95 167 348547 37377 55905976
Cardiogenic shock 10.27 9.95 150 348564 16175 55927178
Atrial pressure increased 10.22 9.95 4 348710 15 55943338
Amylase increased 10.22 9.95 66 348648 5705 55937648
Blindness transient 10.21 9.95 46 348668 3464 55939889
Autoimmune encephalopathy 10.21 9.95 3 348711 3 55943350
Abdominal wall mass 10.21 9.95 3 348711 3 55943350
Fructosamine increased 10.21 9.95 3 348711 3 55943350
Aortic aneurysm 10.18 9.95 45 348669 3361 55939992
Drug specific antibody present 10.17 9.95 5 348709 3667 55939686
Deafness 10.16 9.95 151 348563 16343 55927010
Blood glucose fluctuation 10.13 9.95 53 348661 4242 55939111
Leukocyturia 10.13 9.95 22 348692 1113 55942240
Flushing 10.12 9.95 344 348370 69756 55873597
Left ventricular end-diastolic pressure increased 10.08 9.95 12 348702 361 55942992
Cardiac amyloidosis 10.06 9.95 18 348696 789 55942564
Congenital bowing of long bones 10.04 9.95 6 348708 66 55943287
Transient acantholytic dermatosis 10.04 9.95 6 348708 66 55943287
Reversible cerebral vasoconstriction syndrome 10.03 9.95 35 348679 2342 55941011
Erythema marginatum 10.02 9.95 4 348710 16 55943337
Dialysis 10.02 9.95 98 348616 9604 55933749
Loss of consciousness 10.01 9.95 797 347917 108552 55834801
Collagen disorder 10.01 9.95 9 348705 193 55943160
Central nervous system lesion 10.00 9.95 30 348684 9908 55933445

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 1224.91 11.86 2618 337764 74640 31282322
Immune-mediated myositis 1220.30 11.86 527 339855 1325 31355637
Rhabdomyolysis 789.97 11.86 1958 338424 61623 31295339
Drug abuse 521.34 11.86 148 340234 87610 31269352
Blood creatine phosphokinase increased 509.82 11.86 1282 339100 40692 31316270
Toxicity to various agents 497.38 11.86 737 339645 180750 31176212
Off label use 468.92 11.86 2030 338352 345244 31011718
Febrile neutropenia 395.55 11.86 435 339947 121414 31235548
Myopathy 389.57 11.86 530 339852 10322 31346640
Foetal exposure during pregnancy 384.02 11.86 12 340370 40864 31316098
Necrotising myositis 353.38 11.86 155 340227 410 31356552
Myocardial infarction 350.17 11.86 2250 338132 111204 31245758
Drug ineffective 300.64 11.86 2761 337621 392812 30964150
Coronary artery disease 258.97 11.86 1081 339301 45006 31311956
Pyrexia 226.76 11.86 2129 338253 301711 31055251
Completed suicide 226.39 11.86 397 339985 91117 31265845
Neutropenia 224.97 11.86 764 339618 139600 31217362
Cerebrovascular accident 206.74 11.86 1512 338870 77972 31278990
Acute myocardial infarction 189.82 11.86 1060 339322 49763 31307199
Drug hypersensitivity 185.90 11.86 1376 339006 71223 31285739
Angina pectoris 182.98 11.86 716 339666 28925 31328037
Premature baby 167.20 11.86 6 340376 18060 31338902
Dizziness 165.84 11.86 3031 337351 196116 31160846
Acute kidney injury 160.36 11.86 4032 336350 275682 31081280
Blood cholesterol increased 157.07 11.86 468 339914 16425 31340537
Muscular weakness 148.94 11.86 1207 339175 64241 31292721
Chest pain 147.28 11.86 1910 338472 115047 31241915
Low density lipoprotein increased 145.71 11.86 199 340183 3889 31353073
Treatment failure 138.48 11.86 140 340242 40652 31316310
Drug resistance 138.32 11.86 40 340342 23413 31333549
Coronary artery stenosis 129.30 11.86 291 340091 8579 31348383
Mucosal inflammation 128.90 11.86 108 340274 34319 31322643
Polymyositis 124.94 11.86 111 340271 1304 31355658
Muscle rupture 120.59 11.86 132 340250 2031 31354931
Malignant neoplasm progression 118.40 11.86 442 339940 78556 31278406
Bone marrow failure 116.22 11.86 79 340303 27929 31329033
Muscle spasms 116.17 11.86 1183 339199 67135 31289827
Coronary artery occlusion 114.99 11.86 306 340076 10050 31346912
Cytomegalovirus infection 111.80 11.86 63 340319 24644 31332318
Product use in unapproved indication 104.50 11.86 630 339752 98541 31258421
Transient ischaemic attack 104.33 11.86 523 339859 23533 31333429
Death 101.81 11.86 3023 337359 357546 30999416
Autoimmune myositis 101.43 11.86 39 340343 63 31356899
High density lipoprotein decreased 99.89 11.86 145 340237 3005 31353957
Product monitoring error 99.36 11.86 148 340234 3142 31353820
Pancytopenia 98.80 11.86 542 339840 86774 31270188
Mitral valve incompetence 98.23 11.86 353 340029 13680 31343282
Platelet count decreased 96.73 11.86 741 339641 109694 31247268
Sepsis 95.95 11.86 1106 339276 150823 31206139
Angina unstable 95.53 11.86 301 340081 10894 31346068
Dyspnoea 95.12 11.86 4552 335830 338927 31018035
Syncope 93.62 11.86 1358 339024 83824 31273138
Acute coronary syndrome 88.92 11.86 321 340061 12468 31344494
Graft versus host disease 88.63 11.86 6 340376 10441 31346521
Pneumonia 88.53 11.86 2836 337546 332476 31024486
Leukopenia 87.64 11.86 322 340060 57506 31299456
White blood cell count decreased 87.51 11.86 564 339818 86834 31270128
Thrombocytopenia 87.48 11.86 1046 339336 141701 31215261
Drug dependence 85.54 11.86 70 340312 22509 31334453
Erectile dysfunction 85.40 11.86 421 339961 18814 31338148
Ischaemic stroke 85.25 11.86 385 339997 16586 31340376
Respiratory depression 85.10 11.86 25 340357 14485 31342477
Ascites 85.02 11.86 197 340185 40816 31316146
Neutrophil count decreased 84.48 11.86 238 340144 46156 31310806
Tendon rupture 84.22 11.86 204 340178 6315 31350647
Myelosuppression 79.98 11.86 30 340352 14890 31342072
Drug interaction 77.11 11.86 2850 337532 205693 31151269
Type 2 diabetes mellitus 76.98 11.86 339 340043 14445 31342517
Blood triglycerides increased 74.99 11.86 314 340068 13083 31343879
Pneumocystis jirovecii pneumonia 73.71 11.86 53 340329 18198 31338764
Stomatitis 72.78 11.86 201 340181 39237 31317725
Hypomagnesaemia 72.77 11.86 400 339982 18658 31338304
Exposure during pregnancy 72.76 11.86 5 340377 8593 31348369
Atrial fibrillation 71.77 11.86 1663 338719 112120 31244842
Suicide attempt 70.12 11.86 188 340194 37060 31319902
Infusion related reaction 69.94 11.86 272 340110 47783 31309179
Vascular stent thrombosis 69.81 11.86 115 340267 2670 31354292
Overdose 69.07 11.86 579 339803 84085 31272877
Disease progression 67.49 11.86 633 339749 89831 31267131
Plasma cell myeloma 67.21 11.86 345 340037 56186 31300776
Product use issue 67.13 11.86 347 340035 56412 31300550
Asthenia 67.04 11.86 3002 337380 221753 31135209
Low density lipoprotein decreased 66.73 11.86 69 340313 991 31355971
Amnesia 66.47 11.86 455 339927 22947 31334015
Cardiac failure 66.06 11.86 1293 339089 84660 31272302
Multiple organ dysfunction syndrome 65.30 11.86 446 339936 67757 31289205
Muscle disorder 64.58 11.86 101 340281 2241 31354721
Bronchopulmonary aspergillosis 64.26 11.86 33 340349 13601 31343361
Respiratory arrest 63.87 11.86 115 340267 26142 31330820
Haematuria 63.15 11.86 768 339614 45546 31311416
Myositis 62.86 11.86 261 340121 10833 31346129
Poisoning 62.61 11.86 17 340365 10374 31346588
Presyncope 62.39 11.86 358 340024 16970 31339992
Low birth weight baby 62.20 11.86 3 340379 6967 31349995
Rheumatoid arthritis 61.92 11.86 283 340099 47526 31309436
Oedema peripheral 61.04 11.86 1578 338804 108261 31248701
Disseminated intravascular coagulation 60.46 11.86 79 340303 20458 31336504
Fall 60.24 11.86 2507 337875 183582 31173380
Glycosylated haemoglobin increased 59.97 11.86 246 340136 10154 31346808
Muscle necrosis 59.48 11.86 59 340323 804 31356158
Intentional self-injury 58.74 11.86 35 340347 13280 31343682
Dyspnoea exertional 58.73 11.86 657 339725 38180 31318782
Haemophagocytic lymphohistiocytosis 58.51 11.86 26 340356 11652 31345310
Pain in extremity 58.46 11.86 1648 338734 114555 31242407
Intentional overdose 57.87 11.86 238 340144 41151 31315811
Myopathy toxic 57.22 11.86 46 340336 466 31356496
Inferior vena cava dilatation 57.06 11.86 52 340330 633 31356329
Labelled drug-drug interaction medication error 56.94 11.86 286 340096 12877 31344085
Pathogen resistance 56.82 11.86 12 340370 8689 31348273
C-reactive protein abnormal 56.68 11.86 8 340374 7761 31349201
Cardiac failure chronic 56.57 11.86 190 340192 7113 31349849
Blood glucose increased 56.46 11.86 946 339436 60137 31296825
Diabetic ketoacidosis 56.18 11.86 342 340040 16563 31340399
Lactic acidosis 56.15 11.86 557 339825 31380 31325582
Immune reconstitution inflammatory syndrome 56.10 11.86 10 340372 8168 31348794
Serotonin syndrome 55.49 11.86 72 340310 18701 31338261
Cytokine release syndrome 55.46 11.86 58 340324 16584 31340378
Respiratory failure 55.20 11.86 762 339620 100687 31256275
Intentional product use issue 54.86 11.86 308 340074 49039 31307923
Aspergillus infection 54.19 11.86 28 340354 11500 31345462
Muscle atrophy 53.83 11.86 181 340201 6780 31350182
Rectal haemorrhage 53.02 11.86 610 339772 35694 31321268
Seizure 52.63 11.86 754 339628 99014 31257948
Bradycardia 52.61 11.86 1041 339341 68286 31288676
Neurotoxicity 52.46 11.86 58 340324 16168 31340794
N-terminal prohormone brain natriuretic peptide increased 51.83 11.86 88 340294 2096 31354866
Ischaemic cardiomyopathy 51.64 11.86 160 340222 5737 31351225
Septic shock 51.03 11.86 459 339923 65699 31291263
Muscle injury 50.93 11.86 67 340315 1261 31355701
Therapeutic product effect incomplete 50.62 11.86 269 340113 43427 31313535
Cardiac disorder 50.34 11.86 643 339739 38571 31318391
Posterior reversible encephalopathy syndrome 49.93 11.86 19 340363 9348 31347614
Acute myeloid leukaemia 49.84 11.86 77 340305 18595 31338367
Hyperkalaemia 49.07 11.86 967 339415 63384 31293578
Infection 48.74 11.86 604 339778 81327 31275635
Chromaturia 48.70 11.86 276 340106 13022 31343940
Upper gastrointestinal haemorrhage 48.13 11.86 419 339963 22764 31334198
Melaena 47.83 11.86 549 339833 32105 31324857
Myocardial necrosis marker increased 47.16 11.86 71 340311 1522 31355440
Ejection fraction decreased 46.59 11.86 334 340048 17100 31339862
Glomerular filtration rate decreased 45.94 11.86 250 340132 11615 31345347
Product prescribing error 45.58 11.86 364 340018 19278 31337684
Intentional product misuse 44.88 11.86 232 340150 37719 31319243
Faeces discoloured 44.61 11.86 277 340105 13509 31343453
Epstein-Barr virus infection 44.57 11.86 10 340372 6943 31350019
Low density lipoprotein abnormal 44.27 11.86 33 340349 296 31356666
Drug ineffective for unapproved indication 44.09 11.86 77 340305 17713 31339249
Troponin increased 43.74 11.86 218 340164 9784 31347178
Agitation 43.46 11.86 372 340010 53797 31303165
Hepatic encephalopathy 42.97 11.86 50 340332 13621 31343341
Post transplant lymphoproliferative disorder 42.63 11.86 7 340375 6069 31350893
Haematotoxicity 42.40 11.86 12 340370 7125 31349837
Product substitution issue 42.26 11.86 207 340175 9225 31347737
Condition aggravated 42.17 11.86 1391 338991 162618 31194344
Ventricular hypokinesia 41.72 11.86 130 340252 4676 31352286
Hypoglycaemia 41.37 11.86 773 339609 50173 31306789
Progressive multifocal leukoencephalopathy 40.95 11.86 24 340358 9189 31347773
Atrial septal defect 40.50 11.86 12 340370 6915 31350047
Muscle enzyme increased 40.44 11.86 28 340354 221 31356741
Myocardial ischaemia 40.40 11.86 312 340070 16355 31340607
Hypertensive emergency 40.10 11.86 51 340331 927 31356035
Dermatomyositis 40.10 11.86 57 340325 1158 31355804
Neuroleptic malignant syndrome 40.03 11.86 75 340307 16794 31340168
Cystitis haemorrhagic 39.65 11.86 5 340377 5284 31351678
Carotid artery stenosis 39.61 11.86 125 340257 4527 31352435
Tumour lysis syndrome 39.59 11.86 65 340317 15320 31341642
Amyotrophic lateral sclerosis 39.36 11.86 51 340331 945 31356017
Blood cholesterol decreased 39.36 11.86 51 340331 945 31356017
Arteriosclerosis coronary artery 39.33 11.86 230 340152 10978 31345984
Appendicitis 39.29 11.86 39 340343 11426 31345536
Hepatic cytolysis 39.22 11.86 224 340158 10599 31346363
Therapy partial responder 39.04 11.86 11 340371 6551 31350411
Hepatitis cholestatic 38.84 11.86 166 340216 6980 31349982
Myelodysplastic syndrome 38.66 11.86 94 340288 19157 31337805
Restlessness 38.12 11.86 126 340256 23235 31333727
Hypotension 37.84 11.86 2616 337766 202002 31154960
Palpitations 37.81 11.86 551 339831 34032 31322930
Exercise lack of 37.63 11.86 21 340361 107 31356855
Arteriosclerosis 37.17 11.86 220 340162 10547 31346415
Nocturia 36.71 11.86 196 340186 9039 31347923
Computerised tomogram coronary artery abnormal 36.65 11.86 25 340357 192 31356770
Coronary artery bypass 36.42 11.86 124 340258 4675 31352287
Neoplasm progression 36.15 11.86 105 340277 20167 31336795
Orthostatic hypotension 35.99 11.86 407 339975 23712 31333250
Hepatocellular carcinoma 35.92 11.86 25 340357 8731 31348231
Exercise tolerance decreased 35.92 11.86 121 340261 4537 31352425
Hepatitis C 35.48 11.86 37 340345 10593 31346369
Hepatocellular injury 35.12 11.86 370 340012 21174 31335788
Hyperlipidaemia 35.10 11.86 252 340130 12908 31344054
Polymyalgia rheumatica 35.01 11.86 57 340325 1310 31355652
Cardiac failure congestive 34.78 11.86 1107 339275 78280 31278682
Cerebral haemorrhage 34.78 11.86 520 339862 32292 31324670
Vomiting 34.45 11.86 2011 338371 221962 31135000
Bacteraemia 33.94 11.86 88 340294 17546 31339416
Pancreatitis acute 33.80 11.86 422 339960 25178 31331784
Akathisia 33.52 11.86 18 340364 7235 31349727
Tricuspid valve incompetence 33.49 11.86 185 340197 8644 31348318
Maternal exposure during pregnancy 33.49 11.86 5 340377 4651 31352311
Heart rate irregular 33.26 11.86 265 340117 14024 31342938
Cardio-respiratory arrest 33.18 11.86 375 340007 51351 31305611
Enterococcal infection 33.15 11.86 27 340355 8704 31348258
Lymphocyte count decreased 32.58 11.86 113 340269 20536 31336426
Blood cholesterol 32.57 11.86 23 340359 188 31356774
Diabetic nephropathy 32.52 11.86 69 340313 1952 31355010
Muscle fatigue 32.43 11.86 54 340328 1265 31355697
Coronary artery restenosis 31.99 11.86 47 340335 985 31355977
Coma 31.93 11.86 285 340097 40865 31316097
Drug use disorder 31.80 11.86 3 340379 3980 31352982
Febrile bone marrow aplasia 31.40 11.86 23 340359 7823 31349139
Substance abuse 31.32 11.86 19 340363 7139 31349823
Psychotic disorder 31.27 11.86 128 340254 22165 31334797
Haematoma 31.05 11.86 396 339986 23743 31333219
Genital swelling 30.81 11.86 20 340362 140 31356822
Cytopenia 30.75 11.86 44 340338 10966 31345996
Haemorrhagic stroke 30.70 11.86 138 340244 5932 31351030
Cytomegalovirus viraemia 30.63 11.86 17 340365 6708 31350254
Blood loss anaemia 30.13 11.86 163 340219 7556 31349406
Mixed liver injury 30.05 11.86 73 340309 2264 31354698
Drug withdrawal syndrome 30.00 11.86 102 340280 18648 31338314
Blood creatine phosphokinase MB increased 29.55 11.86 62 340320 1740 31355222
Aggression 29.50 11.86 257 340125 37034 31319928
Haematochezia 29.48 11.86 604 339778 39860 31317102
Status epilepticus 29.46 11.86 53 340329 12053 31344909
Myoglobin blood increased 29.35 11.86 75 340307 2402 31354560
Vascular stent stenosis 28.98 11.86 46 340336 1034 31355928
Intermittent claudication 28.78 11.86 68 340314 2071 31354891
Hypocalcaemia 28.46 11.86 361 340021 21617 31335345
Carotid artery occlusion 28.36 11.86 66 340316 1990 31354972
Liver function test abnormal 28.21 11.86 462 339920 29230 31327732
Type V hyperlipidaemia 28.14 11.86 37 340345 696 31356266
Blood cholesterol abnormal 27.92 11.86 57 340325 1568 31355394
Transplant rejection 27.91 11.86 38 340344 9670 31347292
Stent placement 27.88 11.86 113 340269 4638 31352324
Acute respiratory distress syndrome 27.35 11.86 153 340229 24387 31332575
Glycogen storage disease type V 27.29 11.86 12 340370 32 31356930
Hepatitis B reactivation 27.18 11.86 3 340379 3515 31353447
Depressed level of consciousness 27.11 11.86 274 340108 38327 31318635
Tendonitis 27.09 11.86 171 340211 8387 31348575
Diabetes mellitus inadequate control 26.82 11.86 231 340151 12510 31344452
Aplastic anaemia 26.48 11.86 36 340346 9167 31347795
Respiratory distress 26.20 11.86 232 340150 33321 31323641
Sedation 25.91 11.86 110 340272 18855 31338107
Pseudomonas infection 25.91 11.86 52 340330 11349 31345613
Type IIa hyperlipidaemia 25.77 11.86 22 340360 244 31356718
Ventricular enlargement 25.32 11.86 28 340354 436 31356526
Stenosis 25.29 11.86 46 340336 1159 31355803
Cholestasis 25.27 11.86 394 339988 24681 31332281
Blood urea abnormal 25.16 11.86 36 340346 736 31356226
Electrocardiogram abnormal 25.09 11.86 160 340222 7876 31349086
Candida infection 24.96 11.86 90 340292 16168 31340794
Balance disorder 24.81 11.86 551 339831 36871 31320091
Carotid artery disease 24.79 11.86 38 340344 828 31356134
Degenerative mitral valve disease 24.77 11.86 20 340362 204 31356758
Dystonia 24.67 11.86 45 340337 10180 31346782
Cardiac failure acute 24.53 11.86 184 340198 9557 31347405
Hypercholesterolaemia 24.53 11.86 159 340223 7871 31349091
Abdominal pain 24.51 11.86 1299 339083 144653 31212309
Pneumatosis intestinalis 24.47 11.86 5 340377 3706 31353256
Toxic epidermal necrolysis 24.42 11.86 117 340265 19407 31337555
Gastrointestinal haemorrhage 24.38 11.86 1102 339280 81447 31275515
Product odour abnormal 24.35 11.86 34 340348 679 31356283
Pruritus genital 24.02 11.86 30 340352 535 31356427
Patent ductus arteriosus 23.98 11.86 3 340379 3190 31353772
Nephropathy toxic 23.95 11.86 54 340328 11299 31345663
Muscle discomfort 23.80 11.86 13 340369 63 31356899
Lipids abnormal 23.80 11.86 24 340358 334 31356628
Musculoskeletal pain 23.66 11.86 451 339931 29377 31327585
Epilepsy 23.55 11.86 131 340251 20910 31336052
Hyperammonaemia 23.47 11.86 17 340365 5816 31351146
Foetal growth restriction 23.44 11.86 6 340376 3809 31353153
Paradoxical drug reaction 23.35 11.86 3 340379 3126 31353836
Ocular myasthenia 23.34 11.86 20 340362 223 31356739
Normocytic anaemia 23.21 11.86 61 340321 1988 31354974
Abnormal behaviour 23.20 11.86 155 340227 23673 31333289
Oropharyngeal pain 23.15 11.86 221 340161 31262 31325700
Klebsiella infection 22.98 11.86 30 340352 7773 31349189
Hepatic enzyme increased 22.95 11.86 526 339856 35382 31321580
Swollen tongue 22.93 11.86 225 340157 12637 31344325
Hypoalbuminaemia 22.82 11.86 53 340329 10975 31345987
Colitis 22.79 11.86 243 340139 33644 31323318
Eye injury 22.59 11.86 32 340350 648 31356314
Altered state of consciousness 22.52 11.86 133 340249 20918 31336044
Cardiac aneurysm 22.43 11.86 36 340346 817 31356145
Accidental exposure to product 22.40 11.86 57 340325 11438 31345524
Haemorrhagic transformation stroke 22.32 11.86 48 340334 1371 31355591
Chest discomfort 22.29 11.86 691 339691 48678 31308284
Peripheral vascular disorder 22.21 11.86 105 340277 4611 31352351
Ventricular septal defect 22.18 11.86 6 340376 3671 31353291
Quadriparesis 22.06 11.86 48 340334 1382 31355580
Fungal infection 22.04 11.86 81 340301 14470 31342492
C-reactive protein increased 21.82 11.86 379 340003 48271 31308691
Somnolence 21.76 11.86 860 339522 98585 31258377
Cerebral infarction 21.72 11.86 396 339986 25581 31331381
Apparent death 21.53 11.86 6 340376 3599 31353363
Miosis 21.32 11.86 37 340345 8533 31348429
Arterial occlusive disease 21.22 11.86 94 340288 4015 31352947
Pelvic mass 21.13 11.86 18 340364 199 31356763
Cardiotoxicity 21.09 11.86 14 340368 5013 31351949
Diabetes mellitus 20.93 11.86 602 339780 41954 31315008
Blood immunoglobulin E increased 20.91 11.86 62 340320 2169 31354793
Pulmonary haemorrhage 20.88 11.86 45 340337 9570 31347392
Colorectal cancer 20.87 11.86 13 340369 4816 31352146
Diffuse large B-cell lymphoma 20.87 11.86 38 340344 8603 31348359
Device related infection 20.78 11.86 97 340285 16202 31340760
Iliac artery stenosis 20.78 11.86 12 340370 66 31356896
Arterial stenosis 20.78 11.86 41 340341 1100 31355862
Enthesopathy 20.77 11.86 10 340372 4277 31352685
Catatonia 20.75 11.86 13 340369 4801 31352161
Pollakiuria 20.67 11.86 288 340094 17614 31339348
Nocardiosis 20.64 11.86 6 340376 3501 31353461
Loss of personal independence in daily activities 20.62 11.86 199 340183 28089 31328873
Ageusia 20.61 11.86 171 340211 9160 31347802
Pneumonia cytomegaloviral 20.58 11.86 3 340379 2841 31354121
Immunisation reaction 20.54 11.86 7 340375 6 31356956
Abnormal weight gain 20.15 11.86 37 340345 939 31356023
Essential hypertension 20.04 11.86 68 340314 2559 31354403
Hypogammaglobulinaemia 20.01 11.86 25 340357 6602 31350360
Therapeutic product effect decreased 19.98 11.86 230 340152 31392 31325570
Dyspnoea at rest 19.95 11.86 83 340299 3448 31353514
Potassium wasting nephropathy 19.91 11.86 13 340369 92 31356870
Lymph node calcification 19.90 11.86 15 340367 137 31356825
Sinusitis 19.80 11.86 276 340106 36420 31320542
Memory impairment 19.76 11.86 543 339839 37587 31319375
Radiculitis brachial 19.74 11.86 8 340374 16 31356946
Autoimmune hepatitis 19.73 11.86 89 340293 3831 31353131
Oesophageal carcinoma 19.70 11.86 35 340347 7998 31348964
Pulmonary valve incompetence 19.67 11.86 33 340349 778 31356184
Hepatitis B 19.43 11.86 20 340362 5761 31351201
Crohn's disease 19.38 11.86 10 340372 4111 31352851
Gastrointestinal angiodysplasia 19.37 11.86 28 340354 578 31356384
Lymphadenopathy 19.36 11.86 183 340199 25938 31331024
Hyperbilirubinaemia 19.34 11.86 95 340287 15655 31341307
Pruritus 19.34 11.86 1578 338804 123589 31233373
Cytomegalovirus infection reactivation 19.29 11.86 9 340373 3920 31353042
Tachycardia 19.15 11.86 648 339734 75559 31281403
Urinary retention 19.13 11.86 486 339896 33239 31323723
Ventricular dyskinesia 19.12 11.86 18 340364 229 31356733
Clostridium difficile infection 19.11 11.86 108 340274 17171 31339791
Hepatic failure 19.08 11.86 242 340140 32460 31324502
Weight decreased 19.05 11.86 1979 338403 157973 31198989
Acquired claw toe 19.03 11.86 9 340373 30 31356932
Obstructive pancreatitis 19.00 11.86 24 340358 433 31356529
Pneumonia fungal 18.99 11.86 24 340358 6305 31350657
Aldolase increased 18.98 11.86 11 340371 61 31356901
Venoocclusive disease 18.92 11.86 3 340379 2669 31354293
Synovitis 18.85 11.86 68 340314 12215 31344747
Shock 18.83 11.86 154 340228 22491 31334471
Nicotine dependence 18.83 11.86 25 340357 475 31356487
Pulmonary vascular disorder 18.81 11.86 28 340354 594 31356368
Atrial enlargement 18.69 11.86 21 340361 333 31356629
Cardiac valve disease 18.65 11.86 72 340310 2889 31354073
Left atrial dilatation 18.62 11.86 51 340331 1704 31355258
Shock haemorrhagic 18.62 11.86 179 340203 9998 31346964
Brain oedema 18.42 11.86 73 340309 12759 31344203
Muscle strain 18.42 11.86 84 340298 3633 31353329
Atrioventricular block second degree 18.38 11.86 79 340303 3330 31353632
Penile haemorrhage 18.37 11.86 28 340354 607 31356355
Blood pressure fluctuation 18.29 11.86 156 340226 22580 31334382
Penis injury 18.28 11.86 18 340364 243 31356719
Skin toxicity 18.25 11.86 11 340371 4148 31352814
Hepatitis acute 18.20 11.86 129 340253 6580 31350382
Scrotal pain 18.15 11.86 33 340349 831 31356131
Nipple pain 18.11 11.86 29 340353 657 31356305
Anti-neutrophil cytoplasmic antibody positive vasculitis 18.07 11.86 32 340350 789 31356173
Therapy non-responder 17.99 11.86 255 340127 33556 31323406
Encephalopathy 17.96 11.86 243 340139 32231 31324731
Post micturition dribble 17.95 11.86 7 340375 12 31356950
Epicondylitis 17.84 11.86 22 340360 387 31356575
Pneumonitis 17.82 11.86 227 340155 30425 31326537
Herpes simplex 17.79 11.86 18 340364 5227 31351735
Blood creatine increased 17.78 11.86 97 340285 4511 31352451
Ileus 17.77 11.86 93 340289 15076 31341886
Systemic candida 17.77 11.86 6 340376 3180 31353782
Diffuse large B-cell lymphoma recurrent 17.68 11.86 5 340377 2970 31353992
Palmar-plantar erythrodysaesthesia syndrome 17.55 11.86 96 340286 15387 31341575
Clonus 17.45 11.86 3 340379 2516 31354446
Transient global amnesia 17.43 11.86 20 340362 325 31356637
Tuberculosis 17.33 11.86 40 340342 8301 31348661
Blood creatine phosphokinase abnormal 17.28 11.86 16 340366 199 31356763
Avoidant personality disorder 17.17 11.86 6 340376 6 31356956
Occupational problem environmental 17.17 11.86 6 340376 6 31356956
Osteonecrosis of jaw 17.14 11.86 110 340272 16961 31340001
Pericardial haemorrhage 17.11 11.86 71 340311 2946 31354016
Immune effector cell-associated neurotoxicity syndrome 17.07 11.86 3 340379 2476 31354486
Blood glucose decreased 17.07 11.86 207 340175 12264 31344698
Gait disturbance 17.05 11.86 1006 339376 76489 31280473
Neutropenic colitis 17.00 11.86 4 340378 2688 31354274
Vertigo 16.94 11.86 345 340037 22740 31334222
Peripheral artery stenosis 16.92 11.86 32 340350 831 31356131
Ventricular arrhythmia 16.92 11.86 100 340282 4791 31352171
Drug level increased 16.92 11.86 137 340245 20049 31336913
Rheumatoid nodule 16.90 11.86 4 340378 2677 31354285
Hypercalcaemia 16.88 11.86 85 340297 13915 31343047
Hypertransaminasaemia 16.87 11.86 91 340291 4213 31352749
Vascular graft 16.76 11.86 44 340338 1433 31355529
Orthopnoea 16.70 11.86 98 340284 4683 31352279
Therapeutic response decreased 16.67 11.86 193 340189 26316 31330646
Pneumonia aspiration 16.63 11.86 304 340078 38422 31318540
Product administered to patient of inappropriate age 16.61 11.86 5 340377 2852 31354110
Withdrawal syndrome 16.61 11.86 67 340315 11650 31345312
Mydriasis 16.56 11.86 28 340354 6524 31350438
Deep vein thrombosis 16.56 11.86 511 339871 60225 31296737
Heart valve incompetence 16.52 11.86 41 340341 1289 31355673
Left atrial enlargement 16.51 11.86 30 340352 755 31356207
Neuromyopathy 16.37 11.86 34 340348 947 31356015
Herbal interaction 16.34 11.86 20 340362 349 31356613
Musculoskeletal stiffness 16.34 11.86 329 340053 40996 31315966
Urine flow decreased 16.32 11.86 37 340345 1096 31355866
Aortic valve replacement 16.32 11.86 29 340353 717 31356245
Nausea 16.25 11.86 2986 337396 304961 31052001
Bacterial infection 16.23 11.86 84 340298 13655 31343307
Peripheral paralysis 16.21 11.86 8 340374 30 31356932
Drug abuser 16.02 11.86 11 340371 3869 31353093
Vitreous detachment 15.95 11.86 31 340351 822 31356140
Haemorrhage intracranial 15.94 11.86 239 340143 14849 31342113
Mastitis 15.93 11.86 14 340368 162 31356800
Haematoma muscle 15.84 11.86 38 340344 1169 31355793
Left ventricular dilatation 15.82 11.86 28 340354 690 31356272
Acute lymphocytic leukaemia 15.77 11.86 9 340373 3497 31353465
Rhinovirus infection 15.76 11.86 9 340373 3496 31353466
Dyskinesia 15.70 11.86 146 340236 20764 31336198
Toe amputation 15.67 11.86 56 340326 2164 31354798
Aortic aneurysm 15.65 11.86 121 340261 6344 31350618
Transplant failure 15.60 11.86 7 340375 3119 31353843
Cardiomyopathy 15.47 11.86 241 340141 15092 31341870
Chronic kidney disease 15.45 11.86 525 339857 37450 31319512
Dyspnoea paroxysmal nocturnal 15.38 11.86 42 340340 1401 31355561
Anticoagulation drug level increased 15.28 11.86 23 340359 493 31356469
Cardiovascular disorder 15.25 11.86 161 340221 9217 31347745
Lip swelling 15.24 11.86 214 340168 13109 31343853
Osteonecrosis 15.24 11.86 87 340295 13797 31343165
Lipodystrophy acquired 15.23 11.86 8 340374 3256 31353706
Hepatic cirrhosis 15.23 11.86 102 340280 15572 31341390
Thrombocytopenic purpura 15.19 11.86 35 340347 1048 31355914
Bilirubin conjugated abnormal 15.18 11.86 11 340371 94 31356868
Cytomegalovirus test positive 15.18 11.86 10 340372 3595 31353367
Brain natriuretic peptide increased 15.17 11.86 97 340285 4779 31352183
Dysmorphism 15.14 11.86 7 340375 3065 31353897
Peripheral ischaemia 15.02 11.86 103 340279 5197 31351765
Neutropenic sepsis 15.01 11.86 75 340307 12304 31344658
Lacunar infarction 14.99 11.86 67 340315 2873 31354089
Wound haematoma 14.97 11.86 9 340373 54 31356908
Staphylococcal infection 14.93 11.86 235 340147 30397 31326565
Microcytic anaemia 14.91 11.86 53 340329 2042 31354920
Autoimmune disorder 14.83 11.86 45 340337 1595 31355367
Oscillopsia 14.77 11.86 8 340374 38 31356924
Discoloured vomit 14.77 11.86 22 340360 467 31356495
Burning feet syndrome 14.73 11.86 11 340371 99 31356863
Lipids increased 14.70 11.86 30 340352 825 31356137
Hyponatraemic syndrome 14.69 11.86 14 340368 181 31356781
Intraventricular haemorrhage 14.65 11.86 69 340313 3025 31353937
Idiopathic pulmonary fibrosis 14.65 11.86 85 340297 4045 31352917
Adrenal insufficiency 14.62 11.86 78 340304 12581 31344381
BK virus infection 14.59 11.86 20 340362 5075 31351887
Gout 14.48 11.86 275 340107 17899 31339063
Blood electrolytes abnormal 14.47 11.86 31 340351 883 31356079
Ataxia 14.44 11.86 80 340302 12783 31344179
Hepatic vein dilatation 14.42 11.86 15 340367 217 31356745
Herpes zoster 14.42 11.86 249 340133 31744 31325218
Clostridium difficile colitis 14.41 11.86 90 340292 13966 31342996
Central obesity 14.36 11.86 22 340360 479 31356483
Angiocardiogram 14.33 11.86 14 340368 187 31356775
Bundle branch block left 14.33 11.86 105 340277 5413 31351549
Chronic coronary syndrome 14.29 11.86 11 340371 104 31356858
Abscess 14.22 11.86 61 340321 10426 31346536
Autoimmune myocarditis 14.22 11.86 14 340368 189 31356773
Flatulence 14.18 11.86 284 340098 18664 31338298
Cells in urine 14.18 11.86 4 340378 0 31356962
Arterial repair 14.18 11.86 4 340378 0 31356962
Eructation 14.17 11.86 85 340297 4094 31352868
Hypernatraemia 14.17 11.86 39 340343 7624 31349338
Ventricular hypertrophy 14.14 11.86 87 340295 4229 31352733
Skin discomfort 14.14 11.86 10 340372 82 31356880
Right ventricular enlargement 14.10 11.86 14 340368 191 31356771
Mitochondrial toxicity 14.08 11.86 5 340377 2568 31354394
Cardiac stress test abnormal 14.08 11.86 18 340364 329 31356633
Alcohol abuse 14.01 11.86 17 340365 4547 31352415
Hepatosplenomegaly 13.99 11.86 13 340369 3930 31353032
Psychomotor hyperactivity 13.92 11.86 48 340334 8739 31348223
AST/ALT ratio abnormal 13.91 11.86 6 340376 15 31356947
Atrioventricular block complete 13.91 11.86 147 340235 8418 31348544
Congestive cardiomyopathy 13.87 11.86 125 340257 6857 31350105
Subarachnoid haemorrhage 13.85 11.86 170 340212 10101 31346861
Glycosylated haemoglobin abnormal 13.85 11.86 12 340370 136 31356826
Product contamination physical 13.85 11.86 7 340375 28 31356934
Congenital diaphragmatic anomaly 13.85 11.86 7 340375 28 31356934
Peripheral swelling 13.81 11.86 875 339507 66990 31289972
Sinus bradycardia 13.77 11.86 194 340188 11893 31345069
Suicidal ideation 13.75 11.86 292 340090 36114 31320848
Infective exacerbation of chronic obstructive airways disease 13.73 11.86 45 340337 1663 31355299
Lipoprotein (a) increased 13.71 11.86 8 340374 45 31356917
Sleep disorder due to a general medical condition 13.69 11.86 13 340369 3889 31353073
Urticaria chronic 13.66 11.86 10 340372 87 31356875
Pseudohyponatraemia 13.64 11.86 9 340373 65 31356897
Escherichia infection 13.64 11.86 37 340345 7267 31349695
Pneumothorax 13.61 11.86 116 340266 16794 31340168
Splenomegaly 13.60 11.86 89 340293 13660 31343302
Colitis microscopic 13.59 11.86 50 340332 1960 31355002
Upper respiratory tract infection 13.58 11.86 228 340154 29194 31327768
Peripheral arterial occlusive disease 13.58 11.86 101 340281 5232 31351730
Inflammation 13.56 11.86 190 340192 25051 31331911
Drug level decreased 13.55 11.86 34 340348 6856 31350106
Portal hypertension 13.55 11.86 12 340370 3713 31353249
Thrombotic microangiopathy 13.55 11.86 53 340329 9298 31347664
Atrial flutter 13.54 11.86 227 340155 14428 31342534
Paraesthesia 13.52 11.86 734 339648 55337 31301625
Non-cardiac chest pain 13.51 11.86 83 340299 4032 31352930
Lipid metabolism disorder 13.45 11.86 17 340365 307 31356655
Speech disorder developmental 13.42 11.86 3 340379 2088 31354874
Encephalitis toxic 13.39 11.86 16 340366 272 31356690
Drug screen positive 13.32 11.86 13 340369 3839 31353123
Peripheral artery occlusion 13.32 11.86 41 340341 1465 31355497
Large intestine polyp 13.30 11.86 124 340258 6868 31350094
Blood pressure increased 13.28 11.86 1010 339372 78623 31278339
Brain stem haematoma 13.25 11.86 11 340371 117 31356845
Electrocardiogram ST-T change 13.22 11.86 22 340360 515 31356447
Ankylosing spondylitis 13.21 11.86 27 340355 5854 31351108
Liver palpable 13.17 11.86 16 340366 277 31356685
Inclusion body myositis 13.14 11.86 6 340376 18 31356944
Arrhythmia 13.13 11.86 456 339926 32621 31324341
Hemianaesthesia 13.12 11.86 10 340372 93 31356869
Cold sweat 13.11 11.86 154 340228 9055 31347907
Staphylococcal sepsis 13.11 11.86 52 340330 9085 31347877
Atrioventricular block 13.05 11.86 128 340254 7187 31349775
Gait inability 13.04 11.86 283 340099 18861 31338101
Angioedema 12.98 11.86 462 339920 33156 31323806
Generalised tonic-clonic seizure 12.97 11.86 144 340238 19787 31337175
Fibrous histiocytoma 12.92 11.86 12 340370 150 31356812
Mycobacterial infection 12.91 11.86 4 340378 2239 31354723
Blood triglycerides decreased 12.87 11.86 10 340372 96 31356866
Euglycaemic diabetic ketoacidosis 12.82 11.86 63 340319 2811 31354151
Renal cancer 12.82 11.86 41 340341 7638 31349324
Subdural haematoma 12.78 11.86 280 340102 18691 31338271
Electrocardiogram ST segment depression 12.76 11.86 53 340329 2200 31354762
Liver transplant 12.74 11.86 5 340377 2414 31354548
Lymphoproliferative disorder 12.74 11.86 6 340376 2599 31354363
Duodenal ulcer haemorrhage 12.72 11.86 91 340291 4655 31352307
Adenocarcinoma gastric 12.71 11.86 35 340347 1173 31355789
Spinal stenosis 12.71 11.86 91 340291 4657 31352305
Carcinoid tumour of the gastrointestinal tract 12.68 11.86 8 340374 53 31356909
Conjunctival hyperaemia 12.66 11.86 4 340378 2212 31354750
Coronary artery surgery 12.62 11.86 10 340372 99 31356863
Impatience 12.57 11.86 17 340365 329 31356633
Spur cell anaemia 12.56 11.86 8 340374 54 31356908
Diabetic metabolic decompensation 12.55 11.86 43 340339 1626 31355336
International normalised ratio increased 12.54 11.86 600 339782 44623 31312339
Behaviour disorder 12.51 11.86 17 340365 4330 31352632
Macroglossia 12.47 11.86 18 340364 371 31356591
Vision blurred 12.46 11.86 560 339822 41355 31315607
Hepatojugular reflux 12.44 11.86 22 340360 542 31356420
Gamma-glutamyltransferase abnormal 12.41 11.86 14 340368 223 31356739
Diabetic foot 12.40 11.86 55 340327 2350 31354612
Peritonitis 12.40 11.86 105 340277 15222 31341740
Food interaction 12.38 11.86 29 340353 878 31356084
Hepatic fibrosis 12.36 11.86 14 340368 3860 31353102
Incorrect route of product administration 12.35 11.86 74 340308 11599 31345363
Sopor 12.35 11.86 73 340309 11479 31345483
Smooth muscle antibody positive 12.34 11.86 5 340377 10 31356952
Acute myeloid leukaemia recurrent 12.33 11.86 3 340379 1971 31354991
Carotid endarterectomy 12.32 11.86 8 340374 56 31356906
Drug dispensed to wrong patient 12.30 11.86 20 340362 459 31356503
Pneumonia klebsiella 12.30 11.86 8 340374 2896 31354066
Mouth swelling 12.30 11.86 43 340339 1643 31355319
Tongue discomfort 12.29 11.86 22 340360 547 31356415
Cystic fibrosis 12.26 11.86 3 340379 1963 31354999
Vascular graft occlusion 12.24 11.86 22 340360 549 31356413
Prostatomegaly 12.20 11.86 93 340289 4854 31352108
Injection site erythema 12.19 11.86 98 340284 14364 31342598
Human herpesvirus 6 infection 12.18 11.86 3 340379 1954 31355008
Aortic valve calcification 12.15 11.86 17 340365 340 31356622
Ventricular tachycardia 12.13 11.86 337 340045 23364 31333598
Staphylococcal bacteraemia 12.11 11.86 41 340341 7507 31349455
Basal ganglia haemorrhage 12.10 11.86 27 340355 791 31356171
Agonal rhythm 12.10 11.86 8 340374 58 31356904
Rales 12.09 11.86 144 340238 8495 31348467
Brain abscess 12.07 11.86 8 340374 2867 31354095
Normal tension glaucoma 12.06 11.86 6 340376 23 31356939
Pulmonary tuberculosis 12.03 11.86 20 340362 4691 31352271
Streptococcal infection 12.03 11.86 19 340363 4548 31352414
Drug specific antibody present 11.99 11.86 8 340374 2857 31354105
Erythema 11.95 11.86 724 339658 79681 31277281
Abnormal loss of weight 11.93 11.86 76 340306 3739 31353223
Gastric ulcer haemorrhage 11.91 11.86 95 340287 5028 31351934
Delirium 11.90 11.86 346 340036 41075 31315887
Myoglobin urine present 11.90 11.86 12 340370 167 31356795
Primary hypoparathyroidism 11.87 11.86 6 340376 24 31356938

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Immune-mediated myositis 1984.73 10.47 800 578179 2316 70347149
Myalgia 1719.46 10.47 4054 574925 163838 70185627
Rhabdomyolysis 1674.41 10.47 2890 576089 92870 70256595
Drug ineffective 872.23 10.47 4334 574645 935418 69414047
Acute kidney injury 799.32 10.47 6605 572374 468019 69881446
Maternal exposure during pregnancy 782.27 10.47 38 578941 115307 70234158
Blood creatine phosphokinase increased 759.58 10.47 1598 577381 59665 70289800
Myocardial infarction 750.35 10.47 3081 575898 168564 70180901
Myopathy 741.90 10.47 836 578143 17776 70331689
Rheumatoid arthritis 733.41 10.47 780 578199 291025 70058440
Off label use 680.52 10.47 3440 575539 739620 69609845
Cerebrovascular accident 620.32 10.47 2567 576412 140903 70208562
Necrotising myositis 589.34 10.47 246 578733 800 70348665
Toxicity to various agents 589.26 10.47 1414 577565 380758 69968707
Hand deformity 575.33 10.47 32 578947 86450 70263015
Pemphigus 542.42 10.47 34 578945 83002 70266463
Synovitis 534.71 10.47 193 578786 129035 70220430
Coronary artery disease 525.81 10.47 1405 577574 61331 70288134
Completed suicide 524.02 10.47 650 578329 226485 70122980
Exposure during pregnancy 520.25 10.47 55 578924 87662 70261803
Acute myocardial infarction 512.73 10.47 1532 577447 71355 70278110
Drug abuse 511.90 10.47 282 578697 146974 70202491
Treatment failure 472.79 10.47 296 578683 143846 70205619
Systemic lupus erythematosus 448.13 10.47 137 578842 101765 70247700
Infusion related reaction 432.19 10.47 588 578391 196946 70152519
Glossodynia 426.83 10.47 92 578887 86395 70263070
Contraindicated product administered 404.74 10.47 304 578675 134308 70215157
Therapeutic product effect decreased 392.79 10.47 353 578626 142665 70206800
Pericarditis 390.72 10.47 104 578875 84601 70264864
Febrile neutropenia 377.68 10.47 681 578298 203637 70145828
Drug interaction 373.84 10.47 4754 574225 376687 69972778
Muscular weakness 358.16 10.47 2140 576839 136196 70213269
Rheumatoid factor positive 352.17 10.47 9 578970 48391 70301074
Angina pectoris 329.87 10.47 1006 577973 47377 70302088
Drug intolerance 328.69 10.47 859 578120 224828 70124637
Arthropathy 327.82 10.47 447 578532 149610 70199855
Duodenal ulcer perforation 300.62 10.47 33 578946 51079 70298386
Drug hypersensitivity 280.08 10.47 3325 575654 259134 70090331
Hypomagnesaemia 267.12 10.47 836 578143 39928 70309537
Chest pain 265.83 10.47 3178 575801 248082 70101383
Alopecia 265.55 10.47 787 578192 197703 70151762
Helicobacter infection 265.01 10.47 64 578915 55592 70293873
Stomatitis 257.03 10.47 407 578572 128104 70221361
Product use issue 255.76 10.47 693 578286 179244 70170221
Wound 250.92 10.47 261 578718 98471 70250994
Polymyositis 244.48 10.47 200 578779 2801 70346664
Hyperkalaemia 241.56 10.47 1594 577385 104997 70244468
Joint swelling 239.90 10.47 1156 577823 252055 70097410
Hypersensitivity 226.62 10.47 1034 577945 228778 70120687
Coronary artery stenosis 222.57 10.47 366 578613 11278 70338187
Lactic acidosis 221.09 10.47 1084 577895 63940 70285525
Syncope 219.44 10.47 2192 576787 163517 70185948
Discomfort 216.49 10.47 328 578651 105108 70244357
Pyrexia 214.18 10.47 3576 575403 603376 69746089
Neutropenia 213.41 10.47 1228 577751 255928 70093537
Sleep disorder due to general medical condition, insomnia type 212.88 10.47 22 578957 35710 70313755
Atrial fibrillation 212.43 10.47 2371 576608 181977 70167488
Transient ischaemic attack 210.97 10.47 838 578141 45106 70304359
Angina unstable 209.12 10.47 425 578554 15468 70333997
Folliculitis 204.55 10.47 48 578931 42522 70306943
Irritable bowel syndrome 196.97 10.47 84 578895 50766 70298699
Infection 195.73 10.47 969 578010 209816 70139649
Sinusitis 194.45 10.47 717 578262 168478 70180987
Coronary artery occlusion 193.99 10.47 388 578591 13957 70335508
Hypoglycaemia 190.03 10.47 1371 577608 92993 70256472
Ischaemic stroke 190.01 10.47 619 578360 30201 70319264
Swelling 189.01 10.47 843 578136 187696 70161769
Muscle spasms 188.85 10.47 2006 576973 152040 70197425
Dizziness 188.68 10.47 5041 573938 459100 69890365
Fall 187.35 10.47 4847 574132 439249 69910216
Acute coronary syndrome 179.71 10.47 461 578518 19618 70329847
Pain 177.38 10.47 3849 575130 624967 69724498
Bradycardia 173.02 10.47 1665 577314 122950 70226515
Impaired healing 170.10 10.47 214 578765 74160 70275305
Blood glucose increased 168.54 10.47 1426 577553 101556 70247909
Asthenia 167.57 10.47 4905 574074 452761 69896704
Melaena 165.55 10.47 902 578077 55453 70294012
Product use in unapproved indication 161.42 10.47 1011 577968 206467 70142998
Cardiac failure 161.14 10.47 1837 577142 141704 70207761
Diabetic ketoacidosis 159.62 10.47 593 578386 30919 70318546
Cholestasis 154.89 10.47 787 578192 47085 70302380
Abdominal discomfort 154.38 10.47 1071 577908 213587 70135878
Gastrointestinal haemorrhage 151.32 10.47 1752 577227 135656 70213809
Rectal haemorrhage 150.63 10.47 987 577992 64844 70284621
Dyspnoea 149.86 10.47 7699 571280 762361 69587104
Intentional product use issue 149.53 10.47 492 578487 119650 70229815
Low density lipoprotein increased 148.11 10.47 249 578730 7816 70341649
Autoimmune myositis 146.90 10.47 58 578921 156 70349309
Drug resistance 146.46 10.47 64 578915 38126 70311339
Pregnancy 143.34 10.47 14 578965 23767 70325698
Product monitoring error 141.85 10.47 222 578757 6554 70342911
Myositis 138.77 10.47 384 578595 17105 70332360
Mitral valve incompetence 138.75 10.47 507 578472 26221 70323244
Labelled drug-drug interaction medication error 138.44 10.47 473 578506 23654 70325811
Glycosylated haemoglobin increased 138.14 10.47 382 578597 17009 70332456
Hypertensive emergency 136.52 10.47 132 578847 2331 70347134
Cardiac failure congestive 135.96 10.47 1697 577282 133760 70215705
Cytomegalovirus infection 135.39 10.47 78 578901 39680 70309785
Haematuria 133.99 10.47 934 578045 62639 70286826
Cerebral haemorrhage 133.38 10.47 824 578155 53040 70296425
Myocardial ischaemia 131.54 10.47 466 578513 23734 70325731
Condition aggravated 130.55 10.47 2583 576396 425052 69924413
Mucosal inflammation 123.58 10.47 228 578751 67622 70281843
Haematochezia 123.29 10.47 1019 577960 72062 70277403
Device expulsion 122.01 10.47 18 578961 22228 70327237
Hepatocellular injury 121.70 10.47 717 578262 45374 70304091
Hepatitis cholestatic 121.13 10.47 298 578681 12352 70337113
Myelosuppression 119.65 10.47 48 578931 30097 70319368
Intentional overdose 119.14 10.47 408 578571 98027 70251438
Musculoskeletal stiffness 118.00 10.47 714 578265 147046 70202419
Liver function test abnormal 117.70 10.47 879 578100 60267 70289198
Premature delivery 117.39 10.47 17 578962 21287 70328178
Malignant neoplasm progression 115.61 10.47 555 578424 121184 70228281
Ill-defined disorder 114.57 10.47 168 578811 54573 70294892
Hyponatraemia 112.67 10.47 1885 577094 158202 70191263
Erectile dysfunction 109.81 10.47 300 578679 13262 70336203
Respiratory depression 108.02 10.47 34 578945 24797 70324668
Autoimmune hepatitis 107.45 10.47 258 578721 10528 70338937
Muscle injury 106.82 10.47 94 578885 38400 70311065
Intentional self-injury 106.48 10.47 63 578916 31587 70317878
Nasopharyngitis 106.36 10.47 1230 577749 220976 70128489
Upper gastrointestinal haemorrhage 105.48 10.47 593 578386 36884 70312581
Chromaturia 105.48 10.47 426 578553 23102 70326363
Blood triglycerides increased 105.46 10.47 377 578602 19287 70330178
Bone marrow failure 104.94 10.47 148 578831 48862 70300603
Renal failure 104.76 10.47 2145 576834 186925 70162540
Rash 104.68 10.47 3272 575707 507290 69842175
Cardiac disorder 103.21 10.47 834 578145 58581 70290884
Abortion spontaneous 102.13 10.47 44 578935 26435 70323030
Pancreatitis acute 99.79 10.47 672 578307 44552 70304913
Ischaemic cardiomyopathy 99.49 10.47 195 578784 6909 70342556
Psoriatic arthropathy 99.23 10.47 240 578739 64531 70284934
Gastrointestinal disorder 98.73 10.47 483 578496 104944 70244521
Oedema peripheral 98.70 10.47 2499 576480 225592 70123873
Muscle rupture 97.76 10.47 130 578849 3295 70346170
C-reactive protein increased 94.68 10.47 522 578457 109995 70239470
Blister 93.87 10.47 461 578518 100065 70249400
Rheumatic fever 93.00 10.47 16 578963 17644 70331821
Pancytopenia 91.21 10.47 791 578188 150316 70199149
Muscle necrosis 90.67 10.47 81 578898 1287 70348178
High density lipoprotein decreased 90.50 10.47 138 578841 3981 70345484
Injection site erythema 90.46 10.47 299 578680 72625 70276840
Presyncope 90.35 10.47 569 578410 36869 70312596
Graft versus host disease 90.13 10.47 9 578970 15014 70334451
Neurologic neglect syndrome 89.88 10.47 104 578875 2277 70347188
Fibromyalgia 89.76 10.47 158 578821 47716 70301749
Mixed liver injury 89.30 10.47 173 578806 6076 70343389
Neutrophil count decreased 88.94 10.47 365 578614 83191 70266274
Anaemia 88.29 10.47 4082 574897 399341 69950124
Carotid artery thrombosis 87.50 10.47 106 578873 2440 70347025
Neurotoxicity 87.49 10.47 69 578910 29757 70319708
Product prescribing error 87.26 10.47 581 578398 38371 70311094
Myopathy toxic 87.06 10.47 69 578910 921 70348544
Hepatic enzyme increased 86.44 10.47 841 578138 156149 70193316
Hyperlipidaemia 85.54 10.47 404 578575 23459 70326006
Vascular stent thrombosis 84.52 10.47 123 578856 3400 70346065
Carotid artery stenosis 84.20 10.47 199 578780 8037 70341428
Haematoma 83.74 10.47 679 578300 47739 70301726
Leukopenia 83.45 10.47 518 578461 106042 70243423
Swollen joint count increased 82.74 10.47 8 578971 13692 70335773
Renal impairment 82.70 10.47 1642 577337 142295 70207170
Arteriosclerosis 82.51 10.47 311 578668 16327 70333138
Cardiac failure chronic 81.99 10.47 226 578753 10043 70339422
Caesarean section 81.40 10.47 3 578976 11604 70337861
Faeces discoloured 81.36 10.47 433 578546 26376 70323089
Suicide attempt 81.12 10.47 353 578626 79157 70270308
Myocardial necrosis marker increased 81.08 10.47 111 578868 2895 70346570
Dyspnoea exertional 80.99 10.47 988 577991 77442 70272023
Diabetes mellitus inadequate control 80.90 10.47 383 578596 22262 70327203
Respiratory arrest 80.15 10.47 203 578776 53730 70295735
Red blood cell sedimentation rate abnormal 79.50 10.47 29 578950 19274 70330191
Glomerular filtration rate decreased 79.28 10.47 358 578621 20398 70329067
White blood cell count decreased 79.00 10.47 948 578031 169193 70180272
Blood loss anaemia 76.70 10.47 276 578703 14165 70335300
Hepatic cytolysis 76.30 10.47 335 578644 18857 70330608
Hypocalcaemia 75.92 10.47 626 578353 44233 70305232
Tendon rupture 74.94 10.47 231 578748 10938 70338527
Hip arthroplasty 74.80 10.47 71 578908 27969 70321496
Poisoning 74.74 10.47 46 578933 22576 70326889
Hepatitis acute 74.29 10.47 267 578712 13695 70335770
Injection site pain 73.07 10.47 611 578368 117008 70232457
C-reactive protein abnormal 72.62 10.47 127 578852 38452 70311013
Therapeutic product effect incomplete 72.57 10.47 627 578352 119255 70230210
Pneumocystis jirovecii pneumonia 72.55 10.47 83 578896 29999 70319466
Myoglobin blood increased 72.55 10.47 106 578873 2941 70346524
International normalised ratio increased 72.44 10.47 991 577988 79735 70269730
Chronic kidney disease 72.37 10.47 790 578189 60267 70289198
Injection site reaction 72.27 10.47 190 578789 49662 70299803
Haemophagocytic lymphohistiocytosis 71.89 10.47 35 578944 19577 70329888
Bronchopulmonary aspergillosis 71.80 10.47 41 578938 20961 70328504
Product substitution issue 71.23 10.47 320 578659 18193 70331272
Knee arthroplasty 69.14 10.47 108 578871 34193 70315272
Hypotension 67.23 10.47 3987 574992 400394 69949071
Inferior vena cava dilatation 67.21 10.47 54 578925 736 70348729
Atrioventricular block complete 66.74 10.47 273 578706 14890 70334575
Rheumatoid nodule 66.67 10.47 20 578959 15047 70334418
Polymyalgia rheumatica 66.13 10.47 116 578863 3770 70345695
Haemorrhage intracranial 65.76 10.47 386 578593 24391 70325074
Pathogen resistance 65.75 10.47 14 578965 13265 70336200
Platelet count decreased 65.54 10.47 1041 577938 177181 70172284
Vascular stent stenosis 65.52 10.47 68 578911 1312 70348153
Serotonin syndrome 65.34 10.47 155 578824 41959 70307506
Arteriosclerosis coronary artery 65.20 10.47 284 578695 15931 70333534
Therapeutic response decreased 64.95 10.47 251 578728 58202 70291263
Acute myeloid leukaemia 64.69 10.47 95 578884 30845 70318620
Atrioventricular block 64.44 10.47 239 578740 12449 70337016
Chronic obstructive pulmonary disease 64.00 10.47 939 578040 76702 70272763
Aspergillus infection 63.82 10.47 33 578946 17835 70331630
Hemiplegia 63.41 10.47 253 578726 13642 70335823
Blood creatine phosphokinase MB increased 63.02 10.47 93 578886 2604 70346861
Muscle atrophy 62.76 10.47 207 578772 10163 70339302
Lower respiratory tract infection 62.65 10.47 597 578382 111316 70238149
Ascites 62.34 10.47 311 578668 67236 70282229
Jaundice 61.55 10.47 653 578326 49455 70300010
Drug-induced liver injury 61.50 10.47 715 578264 55398 70294067
Troponin increased 60.81 10.47 283 578696 16331 70333134
Low density lipoprotein abnormal 60.22 10.47 38 578941 343 70349122
Arthralgia 60.08 10.47 3429 575550 499961 69849504
Epstein-Barr virus infection 59.35 10.47 17 578962 13181 70336284
Subdural haematoma 59.13 10.47 426 578553 28872 70320593
Swollen tongue 58.99 10.47 510 578469 36536 70312929
N-terminal prohormone brain natriuretic peptide increased 58.99 10.47 111 578868 3813 70345652
Diabetes mellitus 58.94 10.47 868 578111 70956 70278509
Cerebral infarction 58.82 10.47 573 578406 42436 70307029
Plasma cell myeloma 58.26 10.47 354 578625 72847 70276618
Drug ineffective for unapproved indication 58.08 10.47 144 578835 38394 70311071
Low density lipoprotein decreased 57.87 10.47 58 578921 1072 70348393
Venoocclusive liver disease 57.73 10.47 9 578970 10669 70338796
Pemphigoid 57.46 10.47 247 578732 13775 70335690
Coma 56.64 10.47 478 578501 91366 70258099
Migraine 56.11 10.47 352 578627 71886 70277579
Hemiparesis 55.88 10.47 444 578535 31025 70318440
Coronary artery restenosis 55.84 10.47 61 578918 1251 70348214
Bone erosion 55.74 10.47 27 578952 15146 70334319
Panniculitis 55.50 10.47 10 578969 10666 70338799
Weight decreased 54.77 10.47 3078 575901 307410 70042055
Sedation complication 53.80 10.47 21 578958 13389 70336076
Overdose 53.57 10.47 1019 577960 168726 70180739
Urinary retention 53.52 10.47 660 578319 51860 70297605
Injection site swelling 53.48 10.47 177 578802 42980 70306485
Inflammation 53.33 10.47 399 578580 78266 70271199
Red blood cell sedimentation rate increased 53.22 10.47 151 578828 38491 70310974
Electrocardiogram abnormal 53.10 10.47 249 578730 14415 70335050
Premature labour 53.07 10.47 3 578976 7997 70341468
Immune reconstitution inflammatory syndrome 52.68 10.47 20 578959 12970 70336495
Loss of personal independence in daily activities 52.32 10.47 442 578537 84468 70264997
Haematotoxicity 52.30 10.47 23 578956 13651 70335814
Transplant rejection 52.09 10.47 43 578936 18128 70331337
Amnesia 51.68 10.47 652 578327 51503 70297962
Drug use disorder 51.29 10.47 4 578975 8147 70341318
Adenovirus infection 51.26 10.47 3 578976 7765 70341700
Cytokine release syndrome 50.84 10.47 86 578893 26381 70323084
Dysarthria 50.71 10.47 752 578227 61561 70287904
Injection site pruritus 50.55 10.47 158 578821 39052 70310413
Sedation 50.43 10.47 203 578776 46528 70302937
Nocturia 50.03 10.47 215 578764 11989 70337476
Hyperglycaemia 49.37 10.47 772 578207 63900 70285565
Mobility decreased 49.28 10.47 570 578409 102429 70247036
Blood glucose decreased 49.17 10.47 352 578627 23807 70325658
Eosinophilia 48.85 10.47 524 578455 39795 70309670
Haemorrhagic stroke 48.77 10.47 189 578790 10053 70339412
Accidental exposure to product 48.68 10.47 97 578882 27954 70321511
Progressive multifocal leukoencephalopathy 48.56 10.47 51 578928 19163 70330302
Large intestine polyp 48.45 10.47 204 578775 11272 70338193
Cardiotoxicity 48.43 10.47 15 578964 11055 70338410
Dermatomyositis 48.20 10.47 95 578884 3380 70346085
Multiple-drug resistance 48.05 10.47 3 578976 7352 70342113
Dehydration 48.03 10.47 2282 576697 223860 70125605
Pallor 48.02 10.47 529 578450 40445 70309020
Coronary artery bypass 47.97 10.47 131 578848 5789 70343676
Personality disorder 47.20 10.47 125 578854 5423 70344042
Enthesopathy 47.07 10.47 15 578964 10854 70338611
Cardiac failure acute 46.78 10.47 273 578706 17214 70332251
Orthostatic hypotension 46.74 10.47 636 578343 51107 70298358
Ejection fraction decreased 46.66 10.47 419 578560 30343 70319122
Hepatitis 46.66 10.47 618 578361 49362 70300103
Post transplant lymphoproliferative disorder 46.66 10.47 14 578965 10531 70338934
Lymphocyte count decreased 46.44 10.47 190 578789 43349 70306116
Disease progression 46.27 10.47 951 578028 155721 70193744
Adjustment disorder 46.11 10.47 88 578891 3056 70346409
Haemorrhagic transformation stroke 46.06 10.47 78 578901 2463 70347002
Tricuspid valve incompetence 45.63 10.47 275 578704 17542 70331923
Type V hyperlipidaemia 45.52 10.47 48 578931 944 70348521
Haematemesis 45.40 10.47 603 578376 48194 70301271
Intentional product misuse 45.23 10.47 423 578556 79172 70270293
Candida infection 45.09 10.47 138 578841 34335 70315130
Muscle enzyme increased 44.44 10.47 31 578948 336 70349129
Ocular myasthenia 44.16 10.47 32 578947 370 70349095
Cholestatic liver injury 44.02 10.47 102 578877 4066 70345399
Euglycaemic diabetic ketoacidosis 43.86 10.47 128 578851 5879 70343586
Muscle disorder 43.72 10.47 117 578862 5108 70344357
Confusional state 43.65 10.47 2785 576194 281613 70067852
Drug tolerance decreased 43.60 10.47 13 578966 9820 70339645
Adverse drug reaction 43.49 10.47 256 578723 53088 70296377
Computerised tomogram coronary artery abnormal 42.95 10.47 25 578954 192 70349273
Myelodysplastic syndrome 42.80 10.47 114 578865 29671 70319794
Diabetic nephropathy 42.38 10.47 79 578900 2694 70346771
Angioedema 42.04 10.47 771 578208 65839 70283626
Psychotic disorder 41.81 10.47 162 578817 37539 70311926
Cardio-respiratory arrest 41.51 10.47 575 578404 100102 70249363
Tenosynovitis 41.41 10.47 32 578947 13944 70335521
Dysuria 41.41 10.47 563 578416 45231 70304234
Cerebral haematoma 40.89 10.47 143 578836 7235 70342230
Unintentional medical device removal 40.89 10.47 5 578974 7119 70342346
Exercise lack of 40.82 10.47 32 578947 420 70349045
Cardiac murmur 39.87 10.47 201 578778 11985 70337480
Device dislocation 39.77 10.47 77 578902 22430 70327035
Disseminated intravascular coagulation 39.46 10.47 141 578838 33457 70316008
Aplastic anaemia 39.36 10.47 47 578932 16669 70332796
Hypercholesterolaemia 39.24 10.47 268 578711 17849 70331616
Lichen planopilaris 39.18 10.47 15 578964 36 70349429
Tumour lysis syndrome 38.69 10.47 72 578907 21288 70328177
Headache 38.64 10.47 4148 574831 576257 69773208
Pre-eclampsia 38.61 10.47 4 578975 6481 70342984
Neoplasm progression 38.51 10.47 214 578765 45014 70304451
Arterial stenosis 38.42 10.47 52 578927 1341 70348124
Appendicitis 38.40 10.47 48 578931 16685 70332780
Blood cholesterol abnormal 38.32 10.47 80 578899 2968 70346497
Exercise tolerance decreased 38.30 10.47 151 578828 8097 70341368
Gamma-glutamyltransferase increased 38.29 10.47 604 578375 50081 70299384
Peripheral artery stenosis 37.87 10.47 49 578930 1208 70348257
Lip swelling 37.79 10.47 435 578544 33619 70315846
Carotid artery occlusion 37.74 10.47 96 578883 4063 70345402
Hypertensive crisis 37.68 10.47 278 578701 18984 70330481
Disability 37.61 10.47 40 578939 14943 70334522
Aphasia 37.60 10.47 528 578451 42721 70306744
Febrile bone marrow aplasia 37.42 10.47 26 578953 11965 70337500
Thrombocytopenia 37.39 10.47 1583 577396 237527 70111938
Paradoxical drug reaction 37.26 10.47 5 578974 6631 70342834
Blood cholesterol decreased 37.24 10.47 56 578923 1595 70347870
Hypertransaminasaemia 37.00 10.47 158 578821 8785 70340680
Shock haemorrhagic 36.96 10.47 264 578715 17842 70331623
Ventricular hypertrophy 36.83 10.47 128 578851 6456 70343009
Fungal infection 36.61 10.47 169 578810 37298 70312167
Therapy partial responder 36.41 10.47 29 578950 12445 70337020
Ventricular hypokinesia 36.26 10.47 148 578831 8064 70341401
Seizure 36.21 10.47 1141 577838 176821 70172644
Subarachnoid haemorrhage 36.18 10.47 278 578701 19226 70330239
Blood cholesterol increased 36.08 10.47 734 578245 63870 70285595
Juvenile idiopathic arthritis 36.07 10.47 3 578976 5797 70343668
Device related infection 35.89 10.47 138 578841 32047 70317418
Device adhesion issue 35.43 10.47 4 578975 6059 70343406
Incorrect route of product administration 35.40 10.47 105 578874 26387 70323078
Device issue 35.25 10.47 91 578888 23934 70325531
Sensory loss 35.03 10.47 185 578794 11234 70338231
Pancreatitis 35.00 10.47 712 578267 61956 70287509
Hypovolaemic shock 34.93 10.47 178 578801 10659 70338806
Dyslipidaemia 34.66 10.47 166 578813 9694 70339771
Pain in extremity 34.62 10.47 3119 575860 324963 70024502
Left atrial enlargement 34.40 10.47 43 578936 1023 70348442
Mouth swelling 34.39 10.47 109 578870 5240 70344225
Mydriasis 34.36 10.47 49 578930 16104 70333361
Enterococcal infection 34.34 10.47 41 578938 14541 70334924
Drug dependence 34.34 10.47 172 578807 37149 70312316
Uterine perforation 34.14 10.47 4 578975 5887 70343578
Muscle discomfort 34.11 10.47 20 578959 156 70349309
Arterial occlusive disease 33.76 10.47 139 578840 7603 70341862
Immunodeficiency 33.76 10.47 57 578922 17498 70331967
Cardiac aneurysm 33.55 10.47 49 578930 1359 70348106
Atrial flutter 33.50 10.47 282 578697 20045 70329420
Peripheral vascular disorder 33.27 10.47 137 578842 7495 70341970
Sepsis 33.18 10.47 1644 577335 242901 70106564
Bacteraemia 33.11 10.47 125 578854 29184 70320281
Aortic stenosis 33.08 10.47 124 578855 6492 70342973
Duodenal ulcer 33.07 10.47 226 578753 15054 70334411
Microcytic anaemia 33.02 10.47 100 578879 4689 70344776
Pneumonia 32.94 10.47 4314 574665 591918 69757547
Therapeutic drug monitoring analysis not performed 32.90 10.47 51 578928 1493 70347972
Blood urea abnormal 32.83 10.47 46 578933 1227 70348238
Abortion induced 32.77 10.47 7 578972 6618 70342847
Head injury 32.63 10.47 424 578555 33717 70315748
Epistaxis 32.63 10.47 1082 577897 101545 70247920
Hepatitis toxic 32.62 10.47 97 578882 4502 70344963
Posterior reversible encephalopathy syndrome 32.40 10.47 97 578882 24305 70325160
Multiple sclerosis relapse 32.18 10.47 212 578767 42805 70306660
Heart rate irregular 32.15 10.47 378 578601 29365 70320100
Cardiomyopathy 32.06 10.47 343 578636 26030 70323435
Cystitis haemorrhagic 32.01 10.47 15 578964 8578 70340887
Urinary tract discomfort 31.96 10.47 28 578951 433 70349032
Sinus bradycardia 31.94 10.47 314 578665 23309 70326156
Cytomegalovirus viraemia 31.86 10.47 29 578950 11656 70337809
Type IIa hyperlipidaemia 31.71 10.47 25 578954 331 70349134
Amyotrophic lateral sclerosis 31.55 10.47 54 578925 1720 70347745
Flatulence 31.15 10.47 461 578518 37720 70311745
Scrotal pain 31.07 10.47 29 578950 489 70348976
Stent placement 31.05 10.47 115 578864 5986 70343479
Abnormal loss of weight 31.04 10.47 136 578843 7648 70341817
Amenorrhoea 31.03 10.47 9 578970 6921 70342544
Grip strength decreased 31.03 10.47 50 578929 15635 70333830
Aortic aneurysm 30.97 10.47 137 578842 7736 70341729
Ventricular enlargement 30.69 10.47 29 578950 497 70348968
Rales 30.55 10.47 242 578737 16893 70332572
Blood parathyroid hormone decreased 30.30 10.47 18 578961 9006 70340459
Dystonia 30.19 10.47 73 578906 19633 70329832
Intermittent claudication 30.17 10.47 76 578903 3197 70346268
Gait disturbance 30.10 10.47 1822 577157 183284 70166181
Foetal death 30.04 10.47 7 578972 6232 70343233
Cytomegalovirus infection reactivation 30.01 10.47 9 578970 6772 70342693
Blood creatine phosphokinase abnormal 30.00 10.47 26 578953 396 70349069
Basal ganglia haemorrhage 29.94 10.47 48 578931 1447 70348018
Urinary tract obstruction 29.89 10.47 90 578889 4207 70345258
Blood pressure increased 29.80 10.47 1851 577128 186666 70162799
Gout 29.76 10.47 303 578676 22703 70326762
Colorectal cancer 29.73 10.47 16 578963 8454 70341011
Tuberculosis 29.68 10.47 47 578932 14801 70334664
Idiopathic pulmonary fibrosis 29.51 10.47 97 578882 4754 70344711
Chest discomfort 29.40 10.47 1269 577710 123112 70226353
Exposure via ingestion 29.34 10.47 3 578976 4912 70344553
Labile blood pressure 29.22 10.47 58 578921 2074 70347391
Breast cancer stage I 29.08 10.47 7 578972 6095 70343370
Urticaria 29.05 10.47 1063 577916 161986 70187479
Peripheral arterial occlusive disease 29.04 10.47 130 578849 7379 70342086
Human herpesvirus 6 infection 28.92 10.47 3 578976 4856 70344609
Arrhythmia 28.79 10.47 630 578349 55513 70293952
Dementia 28.66 10.47 294 578685 22071 70327394
Palmar-plantar erythrodysaesthesia syndrome 28.63 10.47 138 578841 30109 70319356
Acne 28.60 10.47 106 578873 24883 70324582
Incorrect dosage administered 28.45 10.47 61 578918 2306 70347159
Diabetic metabolic decompensation 28.27 10.47 71 578908 2981 70346484
Alveolar osteitis 28.17 10.47 29 578950 554 70348911
Joint range of motion decreased 28.12 10.47 113 578866 25913 70323552
Quadriparesis 28.10 10.47 72 578907 3061 70346404
Carotid artery disease 28.09 10.47 58 578921 2135 70347330
Herpes zoster 28.01 10.47 508 578471 84727 70264738
Erythema 27.97 10.47 1337 577642 198226 70151239
Angiopathy 27.93 10.47 117 578862 6450 70343015
Breast cancer stage II 27.81 10.47 5 578974 5341 70344124
Spur cell anaemia 27.71 10.47 14 578965 78 70349387
Pneumatosis intestinalis 27.57 10.47 7 578972 5880 70343585
Flushing 27.56 10.47 488 578491 81684 70267781
Joint destruction 27.56 10.47 3 578976 4675 70344790
Ketoacidosis 27.48 10.47 125 578854 7144 70342321
Pericardial haemorrhage 27.46 10.47 87 578892 4181 70345284
Substance abuse 27.32 10.47 24 578955 9813 70339652
Food allergy 27.25 10.47 18 578961 8506 70340959
Degenerative mitral valve disease 27.19 10.47 20 578959 237 70349228
Eructation 27.17 10.47 154 578825 9606 70339859
Acute respiratory distress syndrome 27.13 10.47 211 578768 41043 70308422
Ventricular tachycardia 27.12 10.47 433 578546 35990 70313475
Ageusia 27.10 10.47 211 578768 14651 70334814
Therapy non-responder 27.01 10.47 453 578526 76462 70273003
Weight increased 26.99 10.47 1661 577318 240670 70108795
Motor dysfunction 26.93 10.47 191 578788 12879 70336586
Pollakiuria 26.90 10.47 403 578576 33058 70316407
Lower gastrointestinal haemorrhage 26.85 10.47 209 578770 14511 70334954
Cardiac valve disease 26.85 10.47 101 578878 5297 70344168
Acute lymphocytic leukaemia recurrent 26.82 10.47 4 578975 4900 70344565
Neuroleptic malignant syndrome 26.80 10.47 115 578864 25892 70323573
Clostridium difficile infection 26.72 10.47 196 578783 38620 70310845
Eating disorder 26.70 10.47 250 578729 18315 70331150
Stenosis 26.61 10.47 55 578924 2026 70347439
Injection site warmth 26.48 10.47 45 578934 13780 70335685
Nocardiosis 26.24 10.47 5 578974 5124 70344341
Diabetic foot 26.20 10.47 71 578908 3123 70346342
Status epilepticus 26.17 10.47 107 578872 24419 70325046
Oral herpes 26.14 10.47 105 578874 24081 70325384
Creatinine renal clearance decreased 26.13 10.47 64 578915 17136 70332329
Polyuria 25.94 10.47 193 578786 13213 70336252
Foetal exposure during pregnancy 25.89 10.47 7 578972 5638 70343827
Prostatomegaly 25.85 10.47 71 578908 3148 70346317
Genital swelling 25.73 10.47 21 578958 293 70349172
Bundle branch block left 25.68 10.47 159 578820 10240 70339225
Complication of device insertion 25.64 10.47 6 578973 5326 70344139
Balance disorder 25.60 10.47 938 578041 89190 70260275
Cell death 25.56 10.47 84 578895 4116 70345349
Breast cancer metastatic 25.56 10.47 27 578952 10119 70339346
Gynaecomastia 25.55 10.47 117 578862 6706 70342759
Adverse event 25.53 10.47 269 578710 49192 70300273
Vertigo 25.49 10.47 681 578298 61962 70287503
Oropharyngeal pain 25.43 10.47 595 578384 95715 70253750
Heavy menstrual bleeding 25.40 10.47 40 578939 12625 70336840
Interstitial lung disease 25.40 10.47 1071 577908 103614 70245851
Inappropriate antidiuretic hormone secretion 25.24 10.47 296 578683 22980 70326485
Hypokalaemia 25.16 10.47 1311 577668 129877 70219588
Intraventricular haemorrhage 25.00 10.47 86 578893 4315 70345150
Herpes simplex 24.97 10.47 33 578946 11199 70338266
Rectal polyp 24.95 10.47 44 578935 1436 70348029
Penile haemorrhage 24.87 10.47 26 578953 506 70348959
Retinal artery occlusion 24.84 10.47 67 578912 2939 70346526
Hepatocellular carcinoma 24.79 10.47 28 578951 10180 70339285
Lacunar infarction 24.63 10.47 102 578877 5594 70343871
Inclusion body myositis 24.57 10.47 8 578971 9 70349456
Depressed level of consciousness 24.54 10.47 535 578444 86896 70262569
Menstruation irregular 24.51 10.47 4 578975 4584 70344881
Atrioventricular block second degree 24.47 10.47 115 578864 6663 70342802
Blood electrolytes abnormal 24.45 10.47 49 578930 1765 70347700
Diabetic retinopathy 24.37 10.47 65 578914 2832 70346633
Dyspnoea at rest 24.11 10.47 115 578864 6704 70342761
Neutropenic colitis 24.11 10.47 6 578973 5108 70344357
Agitation 24.06 10.47 579 578400 92796 70256669
Tongue oedema 23.93 10.47 108 578871 6151 70343314
Adrenal insufficiency 23.82 10.47 115 578864 25080 70324385
Ear infection 23.62 10.47 135 578844 28201 70321264
Blood creatine increased 23.56 10.47 137 578842 8627 70340838
Gastritis erosive 23.47 10.47 152 578827 9943 70339522
Post viral fatigue syndrome 23.38 10.47 20 578959 299 70349166
Aldolase increased 23.29 10.47 18 578961 231 70349234
Poisoning deliberate 23.24 10.47 67 578912 16993 70332472
Pruritus genital 23.17 10.47 36 578943 1056 70348409
Ankylosing spondylitis 23.15 10.47 37 578942 11609 70337856
Anuria 23.15 10.47 254 578725 19399 70330066
Affect lability 23.12 10.47 152 578827 9994 70339471
Diabetic neuropathy 23.09 10.47 102 578877 5756 70343709
Vascular stent occlusion 23.08 10.47 17 578962 202 70349263
Electrolyte imbalance 22.97 10.47 327 578652 26534 70322931
Blood creatinine increased 22.94 10.47 1406 577573 141595 70207870
Palpitations 22.93 10.47 1115 577864 109638 70239827
Benign prostatic hyperplasia 22.92 10.47 155 578824 10288 70339177
Muscle haemorrhage 22.85 10.47 102 578877 5782 70343683
Ovarian cyst 22.84 10.47 38 578941 11734 70337731
Coeliac disease 22.80 10.47 24 578955 9009 70340456
Multiple organ dysfunction syndrome 22.73 10.47 693 578286 107822 70241643
Metabolic acidosis 22.66 10.47 780 578199 73566 70275899
Akathisia 22.65 10.47 41 578938 12252 70337213
Drug withdrawal syndrome 22.61 10.47 165 578814 32550 70316915
Diverticulum 22.58 10.47 190 578789 13503 70335962
Vascular purpura 22.49 10.47 61 578918 2685 70346780
Metastases to bone 22.42 10.47 100 578879 22276 70327189
Penis injury 22.31 10.47 14 578965 125 70349340
Blood sodium decreased 22.14 10.47 366 578613 30632 70318833
Hepatitis B reactivation 22.13 10.47 8 578971 5347 70344118
Hypercalcaemia 22.08 10.47 177 578802 34208 70315257
Arterial insufficiency 22.07 10.47 20 578959 324 70349141
Hepatic encephalopathy 22.07 10.47 99 578880 22019 70327446
Drug tolerance 22.02 10.47 17 578962 7411 70342054
Product complaint 21.95 10.47 173 578806 12058 70337407
Aortic valve incompetence 21.90 10.47 136 578843 8768 70340697
Klebsiella infection 21.85 10.47 53 578926 14239 70335226
Vascular device infection 21.81 10.47 20 578959 8010 70341455
Septic shock 21.80 10.47 724 578255 111534 70237931
Death 21.72 10.47 3747 575232 506314 69843151
Hypogammaglobulinaemia 21.70 10.47 38 578941 11500 70337965
Agitated depression 21.68 10.47 19 578960 294 70349171
Aggression 21.68 10.47 272 578707 48174 70301291
Suicidal ideation 21.57 10.47 419 578560 69177 70280288
Blood pressure fluctuation 21.57 10.47 345 578634 58667 70290798
Drug specific antibody present 21.53 10.47 10 578969 5748 70343717
Cytopenia 21.49 10.47 71 578908 17252 70332213
Orthopnoea 21.47 10.47 141 578838 9267 70340198
Ear congestion 21.42 10.47 54 578925 2273 70347192
Virologic failure 21.38 10.47 3 578976 3847 70345618
Temperature regulation disorder 21.37 10.47 5 578974 4439 70345026
Oesophageal carcinoma 21.35 10.47 27 578952 9339 70340126
Neuropathy peripheral 21.34 10.47 833 578146 126063 70223402
Ventricular internal diameter abnormal 21.32 10.47 15 578964 165 70349300
Injection site rash 21.24 10.47 66 578913 16344 70333121
Gastrointestinal angiodysplasia 21.24 10.47 33 578946 968 70348497
Hyperprolactinaemia 21.15 10.47 5 578974 4408 70345057
Transaminases increased 21.14 10.47 518 578461 46500 70302965
Stillbirth 21.05 10.47 3 578976 3802 70345663
Anti-neutrophil cytoplasmic antibody positive vasculitis 21.02 10.47 67 578912 3230 70346235
Pulmonary vascular disorder 21.01 10.47 32 578947 922 70348543
Maternal exposure timing unspecified 21.00 10.47 5 578974 4386 70345079
Acquired claw toe 20.85 10.47 12 578967 90 70349375
Lipoprotein (a) increased 20.85 10.47 11 578968 68 70349397
Dislocation of vertebra 20.80 10.47 7 578972 4893 70344572
Intracranial haematoma 20.75 10.47 30 578949 824 70348641
Skin necrosis 20.75 10.47 66 578913 16225 70333240
Pulmonary valve incompetence 20.75 10.47 45 578934 1715 70347750
Abnormal weight gain 20.69 10.47 53 578926 2253 70347212
Traumatic coma 20.65 10.47 10 578969 50 70349415
Dysstasia 20.53 10.47 304 578675 24875 70324590
Metastases to central nervous system 20.51 10.47 59 578920 14975 70334490
Coronary artery surgery 20.45 10.47 15 578964 177 70349288
Neutropenic sepsis 20.32 10.47 119 578860 24711 70324754
Neuromyopathy 20.26 10.47 40 578939 1425 70348040
Aortic valve replacement 20.22 10.47 36 578943 1184 70348281
Metastases to liver 20.14 10.47 126 578853 25752 70323713
Generalised tonic-clonic seizure 20.14 10.47 230 578749 41431 70308034
Left atrial dilatation 20.12 10.47 60 578919 2789 70346676
Cardiogenic shock 20.10 10.47 412 578567 35895 70313570
Atrial thrombosis 20.08 10.47 65 578914 3160 70346305
Asthma 20.08 10.47 794 578185 119999 70229466
Decreased appetite 19.98 10.47 2809 576170 301971 70047494
Infarction 19.97 10.47 78 578901 4164 70345301
Injection site bruising 19.97 10.47 206 578773 37826 70311639
Gastritis 19.97 10.47 491 578488 44100 70305365
Crying 19.90 10.47 97 578882 21102 70328363
Brain oedema 19.83 10.47 111 578868 23307 70326158
Chest wall haematoma 19.81 10.47 20 578959 373 70349092
Circulatory collapse 19.79 10.47 403 578576 35071 70314394
Blood iron decreased 19.79 10.47 180 578799 13081 70336384
Lipids increased 19.69 10.47 40 578939 1455 70348010
Bradyarrhythmia 19.69 10.47 74 578905 3879 70345586
Embolic stroke 19.63 10.47 114 578865 7175 70342290
Pulmonary tuberculosis 19.63 10.47 21 578958 7824 70341641
Macroglossia 19.56 10.47 34 578945 1097 70348368
Nodule 19.55 10.47 90 578889 19879 70329586
Intestinal haemorrhage 19.49 10.47 99 578880 5921 70343544
Cardiovascular disorder 19.43 10.47 215 578764 16455 70333010
Peripheral artery occlusion 19.43 10.47 51 578928 2201 70347264
Staphylococcal infection 19.25 10.47 313 578666 53091 70296374
Narrow anterior chamber angle 19.24 10.47 14 578965 163 70349302
Myoglobinaemia 19.23 10.47 12 578967 106 70349359
Fibromatosis colli of infancy 19.14 10.47 7 578972 14 70349451
Acquired plagiocephaly 19.14 10.47 7 578972 14 70349451
Essential hypertension 19.04 10.47 92 578887 5392 70344073
Gastric ulcer 19.03 10.47 365 578614 31425 70318040
Deafness 18.99 10.47 241 578738 19062 70330403
Onychomadesis 18.97 10.47 5 578974 4096 70345369
Carotid arteriosclerosis 18.97 10.47 53 578926 2374 70347091
Pseudomonas infection 18.96 10.47 85 578894 18909 70330556
Renal injury 18.95 10.47 208 578771 15886 70333579
Central obesity 18.91 10.47 41 578938 1562 70347903
Muscle fatigue 18.88 10.47 64 578915 3187 70346278
AST/ALT ratio abnormal 18.82 10.47 7 578972 15 70349450
Vascular graft occlusion 18.79 10.47 26 578953 685 70348780
Occupational problem environmental 18.79 10.47 6 578973 6 70349459
Avoidant personality disorder 18.79 10.47 6 578973 6 70349459
Spinal epidural haematoma 18.78 10.47 37 578942 1316 70348149
Blood glucose abnormal 18.73 10.47 138 578841 9419 70340046
Cold sweat 18.72 10.47 217 578762 16799 70332666
Acute lymphocytic leukaemia 18.70 10.47 11 578968 5534 70343931
Upper respiratory tract infection 18.69 10.47 498 578481 78776 70270689
Hallucination, gustatory 18.67 10.47 10 578969 64 70349401
Diverticulum intestinal 18.65 10.47 121 578858 7920 70341545
Peripheral ischaemia 18.64 10.47 129 578850 8629 70340836
Obstructive pancreatitis 18.60 10.47 26 578953 692 70348773
Blood potassium increased 18.55 10.47 320 578659 27006 70322459
Penile pain 18.53 10.47 30 578949 912 70348553
Osteoporosis 18.52 10.47 284 578695 48623 70300842
Injection site haemorrhage 18.50 10.47 127 578852 25400 70324065
Gastric ulcer haemorrhage 18.44 10.47 126 578853 8392 70341073
Anticoagulation drug level increased 18.43 10.47 26 578953 698 70348767
Cervix neoplasm 18.35 10.47 14 578965 176 70349289
Sopor 18.26 10.47 165 578814 31102 70318363
Disorientation 18.23 10.47 610 578369 57313 70292152
International normalised ratio abnormal 18.20 10.47 88 578891 5159 70344306
Acute left ventricular failure 18.14 10.47 41 578938 1607 70347858
Bacterial infection 18.12 10.47 134 578845 26358 70323107
Immune effector cell-associated neurotoxicity syndrome 18.12 10.47 5 578974 3973 70345492
Glycogen storage disease type V 18.11 10.47 8 578971 31 70349434
Troponin T increased 18.04 10.47 54 578925 2516 70346949
Hypoacusis 18.03 10.47 318 578661 26951 70322514
Left ventricular dysfunction 18.00 10.47 225 578754 17732 70331733
Body height decreased 17.98 10.47 117 578862 7666 70341799
Atrial enlargement 17.98 10.47 25 578954 662 70348803
Catatonia 17.97 10.47 24 578955 8109 70341356
Blood cholesterol 17.90 10.47 23 578956 563 70348902
Transplant dysfunction 17.84 10.47 18 578961 6891 70342574
Peripheral coldness 17.82 10.47 189 578790 14311 70335154
Memory impairment 17.80 10.47 926 578053 91715 70257750
Myoglobinuria 17.75 10.47 31 578948 1004 70348461
Ventricular extrasystoles 17.69 10.47 227 578752 17999 70331466
Fear of injection 17.67 10.47 17 578962 6655 70342810
Periorbital haematoma 17.60 10.47 29 578950 895 70348570
Blood alkaline phosphatase increased 17.59 10.47 613 578366 57908 70291557
Device difficult to use 17.58 10.47 39 578940 10810 70338655
Cholecystitis chronic 17.52 10.47 31 578948 9345 70340120
Breast cancer 17.50 10.47 182 578797 33367 70316098
ECG signs of myocardial ischaemia 17.48 10.47 18 578961 344 70349121
Potassium wasting nephropathy 17.47 10.47 13 578966 157 70349308
Iliac artery stenosis 17.44 10.47 12 578967 127 70349338
Ventricular dyskinesia 17.42 10.47 19 578960 389 70349076
Myasthenia gravis 17.37 10.47 111 578868 7228 70342237
Primary biliary cholangitis 17.36 10.47 32 578947 1082 70348383
Angiocardiogram 17.28 10.47 15 578964 229 70349236
Leukocyturia 17.22 10.47 40 578939 1597 70347868
Hepatojugular reflux 17.12 10.47 23 578956 589 70348876
Blood lactic acid 17.10 10.47 20 578959 443 70349022
Occult blood positive 17.08 10.47 100 578879 6313 70343152
Hepatic vein dilatation 17.07 10.47 15 578964 233 70349232
Lacunar stroke 17.06 10.47 17 578962 312 70349153
Gastroduodenal haemorrhage 17.04 10.47 16 578963 272 70349193
Chronic coronary syndrome 17.01 10.47 11 578968 104 70349361
Coronary artery thrombosis 17.01 10.47 58 578921 2897 70346568
Heart valve incompetence 17.00 10.47 58 578921 2898 70346567
Pneumonia cytomegaloviral 16.93 10.47 8 578971 4553 70344912
Oligohydramnios 16.92 10.47 3 578976 3237 70346228
Pelvic mass 16.91 10.47 32 578947 1104 70348361
Rhinovirus infection 16.87 10.47 18 578961 6715 70342750
Hepatosplenomegaly 16.78 10.47 13 578966 5657 70343808
Blood pressure inadequately controlled 16.75 10.47 90 578889 5502 70343963
Conjunctivitis 16.71 10.47 112 578867 22524 70326941
Sinus node dysfunction 16.70 10.47 108 578871 7061 70342404
Lipids abnormal 16.65 10.47 22 578957 554 70348911
Dyspnoea paroxysmal nocturnal 16.65 10.47 46 578933 2047 70347418
Tubulointerstitial nephritis 16.59 10.47 370 578609 32706 70316759
Diffuse large B-cell lymphoma recurrent 16.54 10.47 4 578975 3472 70345993
Arthritis 16.51 10.47 643 578336 97337 70252128
Cardiac pacemaker insertion 16.46 10.47 87 578892 5285 70344180
Vaginal haemorrhage 16.41 10.47 98 578881 20254 70329211
Hepatic ischaemia 16.38 10.47 30 578949 1009 70348456
Foot deformity 16.37 10.47 100 578879 20555 70328910
Lichenoid keratosis 16.36 10.47 65 578914 3498 70345967
Escherichia infection 16.35 10.47 73 578906 16258 70333207
Iron deficiency anaemia 16.32 10.47 272 578707 22800 70326665
Adjustment disorder with depressed mood 16.31 10.47 7 578972 4216 70345249
Hypovolaemia 16.30 10.47 201 578778 15792 70333673
Electrocardiogram QT prolonged 16.29 10.47 836 578143 82681 70266784
Product odour abnormal 16.29 10.47 33 578946 1198 70348267
Encephalopathy 16.26 10.47 381 578598 61280 70288185
Hepatitis C 16.23 10.47 52 578927 12755 70336710
Atrioventricular block first degree 16.19 10.47 156 578823 11517 70337948
Duodenal ulcer haemorrhage 16.14 10.47 102 578877 6616 70342849
Multiple injuries 16.08 10.47 63 578916 3368 70346097
Prolonged expiration 16.07 10.47 29 578950 964 70348501
Burning feet syndrome 16.01 10.47 13 578966 180 70349285
Dysgeusia 16.01 10.47 523 578456 48979 70300486
Hepatitis B 15.92 10.47 26 578953 8088 70341377
Deformity 15.90 10.47 27 578952 8270 70341195
Non-cardiac chest pain 15.90 10.47 127 578852 8888 70340577
Ventricular arrhythmia 15.88 10.47 114 578865 7716 70341749
Parainfluenzae virus infection 15.87 10.47 11 578968 5069 70344396
Vascular graft 15.73 10.47 43 578936 1901 70347564
Radiculitis brachial 15.69 10.47 9 578970 67 70349398
Cerebral microangiopathy 15.69 10.47 15 578964 261 70349204
Lymphadenopathy 15.65 10.47 292 578687 48499 70300966
Peripheral nerve palsy 15.63 10.47 8 578971 46 70349419
Nodular rash 15.61 10.47 16 578963 304 70349161
Ludwig angina 15.59 10.47 14 578965 224 70349241
Prostate cancer recurrent 15.59 10.47 25 578954 754 70348711
Device use error 15.58 10.47 19 578960 6677 70342788
Bilirubin conjugated abnormal 15.51 10.47 10 578969 94 70349371
Diffuse large B-cell lymphoma 15.50 10.47 56 578923 13246 70336219
Mitral valve calcification 15.49 10.47 35 578944 1372 70348093
Brain natriuretic peptide increased 15.45 10.47 117 578862 8054 70341411
Clonus 15.44 10.47 17 578962 6251 70343214
Agonal rhythm 15.37 10.47 9 578970 70 70349395
Blood magnesium decreased 15.33 10.47 187 578792 14654 70334811
Drug screen positive 15.33 10.47 15 578964 5825 70343640
Dilatation atrial 15.27 10.47 63 578916 3449 70346016
Tachycardia 15.23 10.47 1101 577878 157445 70192020
Eye injury 15.19 10.47 39 578940 1660 70347805
Nipple swelling 15.17 10.47 10 578969 98 70349367
Restlessness 15.16 10.47 247 578732 41881 70307584
Fibrous histiocytoma 15.15 10.47 22 578957 607 70348858
Tunnel vision 15.12 10.47 32 578947 1199 70348266
Infective exacerbation of chronic obstructive airways disease 15.09 10.47 50 578929 2461 70347004
Drug dispensed to wrong patient 15.07 10.47 21 578958 557 70348908
Respiratory failure 15.06 10.47 1179 577800 167556 70181909
Schizophrenia 15.01 10.47 78 578901 16690 70332775
Ecchymosis 14.98 10.47 181 578798 14151 70335314
Glomerular filtration rate abnormal 14.98 10.47 36 578943 1470 70347995
Subdural haemorrhage 14.94 10.47 86 578893 5395 70344070
Encephalitis toxic 14.93 10.47 15 578964 278 70349187
Nail disorder 14.90 10.47 40 578939 10384 70339081
Nightmare 14.88 10.47 259 578720 21897 70327568
Abnormal dreams 14.86 10.47 142 578837 10461 70339004
Muscle relaxant therapy 14.85 10.47 12 578967 165 70349300
Pelvic cyst 14.84 10.47 8 578971 52 70349413
Haematoma muscle 14.82 10.47 47 578932 2260 70347205
Device malfunction 14.81 10.47 93 578886 18991 70330474
Lymphoproliferative disorder 14.80 10.47 13 578966 5316 70344149
Glycosylated haemoglobin abnormal 14.79 10.47 12 578967 166 70349299
Urinary occult blood positive 14.73 10.47 12 578967 167 70349298
Aortic valve thickening 14.73 10.47 6 578973 18 70349447
Toe amputation 14.69 10.47 63 578916 3510 70345955
Urosepsis 14.69 10.47 276 578703 23673 70325792
Calculus urinary 14.65 10.47 43 578936 1981 70347484
Haemorrhage 14.56 10.47 830 578149 82985 70266480
Blood creatinine abnormal 14.53 10.47 73 578906 4346 70345119
Peroneal nerve injury 14.47 10.47 8 578971 55 70349410
Hypertension 14.46 10.47 2685 576294 293348 70056117
Benign gastrointestinal neoplasm 14.44 10.47 11 578968 138 70349327
Liver palpable 14.42 10.47 16 578963 334 70349131
BK virus infection 14.41 10.47 27 578952 7962 70341503
Pulmonary haemorrhage 14.37 10.47 60 578919 13613 70335852
Anosognosia 14.37 10.47 3 578976 2882 70346583
Collagen disorder 14.35 10.47 14 578965 250 70349215
Tobacco abuse 14.35 10.47 26 578953 867 70348598
Blood glucose fluctuation 14.35 10.47 94 578885 6173 70343292
Blood pressure decreased 14.34 10.47 898 578081 90617 70258848
Coordination abnormal 14.31 10.47 197 578782 15869 70333596
Calcium deficiency 14.30 10.47 24 578955 752 70348713
Furuncle 14.26 10.47 102 578877 6896 70342569
Subacute cutaneous lupus erythematosus 14.26 10.47 58 578921 3155 70346310
Prostatic operation 14.03 10.47 13 578966 217 70349248
Subchondral insufficiency fracture 14.01 10.47 8 578971 59 70349406
Blood cholinesterase decreased 14 10.47 14 578965 258 70349207
Scleritis 14.00 10.47 6 578973 3616 70345849
Brain stem haematoma 13.99 10.47 10 578969 113 70349352
Prothrombin consumption time prolonged 13.85 10.47 7 578972 39 70349426
Accelerated hypertension 13.84 10.47 21 578958 603 70348862
Thrombotic microangiopathy 13.84 10.47 87 578892 17761 70331704
Hallucinations, mixed 13.83 10.47 19 578960 6343 70343122
Coronary angioplasty 13.80 10.47 16 578963 351 70349114
Nicotine dependence 13.79 10.47 25 578954 834 70348631
Anaphylactic reaction 13.75 10.47 487 578492 74487 70274978
Thrombotic thrombocytopenic purpura 13.75 10.47 92 578887 6085 70343380
Cystic fibrosis 13.74 10.47 9 578970 4272 70345193
Mood swings 13.74 10.47 90 578889 18196 70331269
Cystostomy 13.68 10.47 8 578971 62 70349403
Cough decreased 13.67 10.47 5 578974 10 70349455
Aortic valve stenosis 13.64 10.47 78 578901 4881 70344584
Acute myeloid leukaemia recurrent 13.61 10.47 4 578975 3050 70346415
Erythema nodosum 13.61 10.47 10 578969 4471 70344994
Device related sepsis 13.60 10.47 16 578963 5712 70343753
Sarcopenia 13.55 10.47 17 578962 406 70349059
Systemic infection 13.55 10.47 97 578882 6560 70342905
Drug level decreased 13.52 10.47 55 578924 12569 70336896
Hiatus hernia 13.46 10.47 245 578734 20889 70328576
Decreased gait velocity 13.45 10.47 11 578968 154 70349311
Epstein-Barr virus associated lymphoproliferative disorder 13.44 10.47 5 578974 3284 70346181
Nipple pain 13.44 10.47 21 578958 619 70348846
Bladder sphincter atony 13.43 10.47 10 578969 121 70349344
Pulmonary renal syndrome 13.40 10.47 20 578959 566 70348899
Diverticulum intestinal haemorrhagic 13.39 10.47 60 578919 3407 70346058
Pulmonary oedema 13.38 10.47 810 578169 81468 70267997
Right ventricular enlargement 13.36 10.47 19 578960 514 70348951
Wound haematoma 13.33 10.47 11 578968 156 70349309
Tongue disorder 13.32 10.47 59 578920 13168 70336297
Bronchial secretion retention 13.31 10.47 4 578975 3006 70346459
Tic 13.29 10.47 3 578976 2730 70346735
Cholelithiasis 13.27 10.47 492 578487 46848 70302617
Quadrantanopia 13.26 10.47 12 578967 194 70349271
Benign pancreatic neoplasm 13.17 10.47 7 578972 44 70349421
Laryngeal haematoma 13.16 10.47 11 578968 159 70349306
Consciousness fluctuating 13.12 10.47 38 578941 1738 70347727
Duodenitis 13.10 10.47 100 578879 6902 70342563
Blood urea increased 13.08 10.47 478 578501 45431 70304034
Intra-abdominal haematoma 13.08 10.47 50 578929 2642 70346823
Femoral bruit 13.06 10.47 5 578974 12 70349453
Internal haemorrhage 13.06 10.47 112 578867 8004 70341461
Post stroke seizure 13.05 10.47 4 578975 3 70349462
Penile discharge 13.04 10.47 7 578972 45 70349420
Xyphoid retraction 12.99 10.47 11 578968 162 70349303
Thyroid disorder 12.96 10.47 161 578818 12671 70336794
Kidney transplant rejection 12.94 10.47 40 578939 9921 70339544
Arteriovenous fistula occlusion 12.93 10.47 19 578960 530 70348935
Renal disorder 12.93 10.47 404 578575 37605 70311860
Photophobia 12.92 10.47 94 578885 18556 70330909
Primary hypoparathyroidism 12.89 10.47 6 578973 27 70349438
Pain in jaw 12.88 10.47 258 578721 42411 70307054
Incision site haemorrhage 12.87 10.47 27 578952 1005 70348460
Hepatic cirrhosis 12.84 10.47 175 578804 30556 70318909
Colitis ulcerative 12.84 10.47 197 578782 33726 70315739
Discoloured vomit 12.83 10.47 31 578948 1270 70348195
Musculoskeletal chest pain 12.78 10.47 260 578719 22621 70326844
Paresis 12.78 10.47 64 578915 3806 70345659
Pneumonia aspiration 12.74 10.47 399 578580 61890 70287575
Device breakage 12.74 10.47 37 578942 9361 70340104
Device deployment issue 12.72 10.47 4 578975 2920 70346545
Haemoglobin increased 12.72 10.47 84 578895 5531 70343934
Dizziness postural 12.69 10.47 134 578845 10134 70339331
Polyp 12.64 10.47 101 578878 7069 70342396
Mitochondrial toxicity 12.63 10.47 4 578975 2906 70346559
Systemic candida 12.62 10.47 18 578961 5916 70343549
Testicular pain 12.58 10.47 39 578940 1852 70347613
Cardiac flutter 12.58 10.47 71 578908 4422 70345043
Toxic anterior segment syndrome 12.57 10.47 3 578976 2627 70346838
Copper metabolism disorder 12.53 10.47 4 578975 4 70349461
Secondary immunodeficiency 12.49 10.47 4 578975 2885 70346580
Urine flow decreased 12.48 10.47 27 578952 1027 70348438
Hypoalbuminaemia 12.48 10.47 98 578881 19024 70330441
Neurosensory hypoacusis 12.41 10.47 12 578967 212 70349253
Lipid metabolism disorder 12.41 10.47 14 578965 298 70349167
Soft tissue disorder 12.40 10.47 6 578973 3368 70346097
Skin toxicity 12.39 10.47 25 578954 7173 70342292
Muscle strain 12.38 10.47 117 578862 8593 70340872
Autoimmune myocarditis 12.36 10.47 15 578964 346 70349119
Aortic arteriosclerosis 12.35 10.47 108 578871 7761 70341704
Phimosis 12.34 10.47 17 578962 446 70349019
Actinic keratosis 12.29 10.47 83 578896 5507 70343958
Hyponatraemic seizure 12.20 10.47 18 578961 504 70348961
Ventricular dysfunction 12.19 10.47 83 578896 5521 70343944
Respiratory acidosis 12.17 10.47 43 578936 10238 70339227
Drug eruption 12.17 10.47 238 578741 39258 70310207
Blood testosterone decreased 12.11 10.47 44 578935 2269 70347196
Heat stroke 12.08 10.47 34 578945 1529 70347936
Product administered to patient of inappropriate age 12.08 10.47 13 578966 4830 70344635
Ligament sprain 12.04 10.47 150 578829 11813 70337652
Portosplenomesenteric venous thrombosis 12.04 10.47 5 578974 16 70349449
Carcinoid tumour of the gastrointestinal tract 12.00 10.47 8 578971 80 70349385
Patient dissatisfaction with treatment 12.00 10.47 10 578969 144 70349321
Cholangiocarcinoma 11.97 10.47 45 578934 2359 70347106
Helicobacter test positive 11.97 10.47 29 578950 1190 70348275
Mucous stools 11.93 10.47 9 578970 3970 70345495
Flank pain 11.90 10.47 205 578774 17297 70332168
Epilepsy 11.86 10.47 234 578745 38550 70310915
Swelling face 11.86 10.47 630 578349 62534 70286931
Movement disorder 11.81 10.47 269 578710 23860 70325605
End stage renal disease 11.81 10.47 141 578838 10992 70338473
Systemic mycosis 11.81 10.47 3 578976 2519 70346946
Overlap syndrome 11.81 10.47 22 578957 750 70348715
Alanine aminotransferase increased 11.79 10.47 1376 577603 146104 70203361
Acute pulmonary oedema 11.76 10.47 164 578815 13248 70336217
Unintended pregnancy 11.76 10.47 6 578973 3267 70346198
Hyperglycaemic hyperosmolar nonketotic syndrome 11.73 10.47 38 578941 1848 70347617
Leukaemia recurrent 11.72 10.47 4 578975 2771 70346694
Renal function test abnormal 11.71 10.47 66 578913 4108 70345357
Food interaction 11.68 10.47 34 578945 1559 70347906
Lymph node calcification 11.68 10.47 15 578964 367 70349098
Brain abscess 11.67 10.47 12 578967 4554 70344911
Aortic aneurysm rupture 11.66 10.47 29 578950 1210 70348255
Nuchal rigidity 11.66 10.47 26 578953 1010 70348455
Drop attacks 11.66 10.47 26 578953 1010 70348455
Blood calcitonin increased 11.65 10.47 6 578973 35 70349430
Cardiac discomfort 11.65 10.47 28 578951 1143 70348322
Mycobacterial infection 11.65 10.47 7 578972 3481 70345984
Eye haemorrhage 11.64 10.47 118 578861 8831 70340634
Renal cyst 11.63 10.47 163 578816 13182 70336283
Linear IgA disease 11.59 10.47 51 578928 2873 70346592
Platelet aggregation test 11.59 10.47 7 578972 58 70349407
Vision blurred 11.57 10.47 913 578066 94071 70255394
Hyperlactacidaemia 11.57 10.47 76 578903 4996 70344469
Peripheral paralysis 11.55 10.47 10 578969 152 70349313
Pneumonia fungal 11.54 10.47 42 578937 9911 70339554
Second primary malignancy 11.52 10.47 61 578918 12990 70336475
Prevertebral soft tissue swelling of cervical space 11.52 10.47 6 578973 36 70349429
Eyelid retraction 11.52 10.47 6 578973 36 70349429
Haemarthrosis 11.51 10.47 80 578899 5359 70344106
Total cholesterol/HDL ratio increased 11.46 10.47 12 578967 234 70349231
Hypervolaemia 11.46 10.47 414 578565 39292 70310173
Aortitis salmonella 11.45 10.47 3 578976 0 70349465
Foreign travel 11.45 10.47 3 578976 0 70349465
Red blood cell acanthocytes present 11.45 10.47 3 578976 0 70349465
Wrong dosage form 11.45 10.47 3 578976 0 70349465
Leukocyte alkaline phosphatase increased 11.45 10.47 3 578976 0 70349465
Implantable cardiac monitor insertion 11.45 10.47 3 578976 0 70349465
Progressive muscular atrophy 11.45 10.47 3 578976 0 70349465
Injection site extravasation 11.44 10.47 35 578944 8711 70340754
Transplant failure 11.43 10.47 10 578969 4097 70345368
Amputation 11.42 10.47 19 578960 591 70348874
Granuloma 11.40 10.47 29 578950 7666 70341799
Disseminated tuberculosis 11.39 10.47 10 578969 4090 70345375
Carotid endarterectomy 11.34 10.47 10 578969 156 70349309
Compartment syndrome 11.33 10.47 69 578910 4417 70345048
Subcutaneous abscess 11.31 10.47 27 578952 7295 70342170
Gait deviation 11.30 10.47 7 578972 61 70349404
Biliary fibrosis 11.28 10.47 4 578975 7 70349458
Oesophageal adenocarcinoma stage 0 11.28 10.47 4 578975 7 70349458
Normocytic anaemia 11.27 10.47 59 578920 3571 70345894
Mean cell haemoglobin concentration 11.25 10.47 6 578973 38 70349427
Bladder pain 11.24 10.47 39 578940 1965 70347500
Left ventricular hypertrophy 11.18 10.47 130 578849 10072 70339393
Stevens-Johnson syndrome 11.18 10.47 216 578763 35691 70313774
Encephalitis 11.17 10.47 65 578914 13520 70335945
Shock 11.16 10.47 248 578731 40177 70309288
Hepatic steatosis 11.13 10.47 358 578621 33455 70316010
Intracranial aneurysm 11.11 10.47 64 578915 4016 70345449
Wound haemorrhage 11.09 10.47 60 578919 3677 70345788
Pyonephrosis 11.08 10.47 8 578971 92 70349373
Extrapyramidal disorder 11.05 10.47 112 578867 20638 70328827
Dry eye 11.05 10.47 191 578788 32091 70317374
Biopsy colon abnormal 11.00 10.47 8 578971 93 70349372
Vitreous haemorrhage 10.97 10.47 56 578923 3356 70346109
Jaundice cholestatic 10.96 10.47 119 578860 9065 70340400
Blood triglycerides decreased 10.95 10.47 11 578968 204 70349261
Haemorrhage urinary tract 10.94 10.47 43 578936 2302 70347163
Anal polyp 10.93 10.47 7 578972 65 70349400
Type 2 diabetes mellitus 10.92 10.47 452 578527 43628 70305837
Pseudohyponatraemia 10.89 10.47 9 578970 128 70349337
Antimitochondrial antibody positive 10.86 10.47 8 578971 95 70349370
Pharyngitis streptococcal 10.86 10.47 40 578939 9408 70340057
Carotid bruit 10.85 10.47 20 578959 676 70348789
Coronary artery embolism 10.84 10.47 13 578966 296 70349169
Acute respiratory failure 10.84 10.47 539 578440 53126 70296339
Skin haemorrhage 10.83 10.47 129 578850 10051 70339414
Embedded device 10.83 10.47 5 578974 2884 70346581
Adenocarcinoma gastric 10.82 10.47 35 578944 1701 70347764
Pelvic pain 10.79 10.47 53 578926 11507 70337958
IIIrd nerve paresis 10.79 10.47 10 578969 167 70349298
Potentiating drug interaction 10.79 10.47 108 578871 8056 70341409
Optic discs blurred 10.75 10.47 7 578972 67 70349398
Smooth muscle antibody positive 10.74 10.47 10 578969 168 70349297
Bone cyst 10.73 10.47 5 578974 2869 70346596
Mycobacterium chelonae infection 10.71 10.47 3 578976 2361 70347104
Blue toe syndrome 10.71 10.47 18 578961 565 70348900
JC virus infection 10.69 10.47 8 578971 3543 70345922
Therapy cessation 10.69 10.47 355 578624 33321 70316144
Streptococcal infection 10.66 10.47 31 578948 7840 70341625
Dyspepsia 10.65 10.47 855 578124 88222 70261243
Renovascular hypertension 10.65 10.47 6 578973 43 70349422
Idiopathic intracranial hypertension 10.65 10.47 5 578974 2856 70346609
Rebound tachycardia 10.62 10.47 4 578975 9 70349456
Post stroke epilepsy 10.62 10.47 4 578975 9 70349456
Animal scratch 10.61 10.47 27 578952 1143 70348322
Contusion 10.60 10.47 900 578079 127136 70222329
Hypertriglyceridaemia 10.59 10.47 145 578834 11666 70337799
Joint laxity 10.54 10.47 3 578976 2336 70347129
Hypertensive angiopathy 10.53 10.47 8 578971 100 70349365
Nerve degeneration 10.50 10.47 12 578967 259 70349206
Gouty arthritis 10.49 10.47 30 578949 1362 70348103
Vitreous detachment 10.49 10.47 39 578940 2034 70347431
Intestinal obstruction 10.48 10.47 239 578740 38586 70310879

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C10AA05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
HMG CoA reductase inhibitors
ATC C10BA05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BX03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX11 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX12 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX15 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX18 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA MoA N0000000121 Hydroxymethylglutaryl-CoA Reductase Inhibitors
FDA EPC N0000175589 HMG-CoA Reductase Inhibitor
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D000924 Anticholesteremic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D019161 Hydroxymethylglutaryl-CoA Reductase Inhibitors
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Arteriosclerotic vascular disease indication 72092001
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Cerebrovascular accident indication 230690007
Familial hypercholesterolemia - homozygous indication 238078005
Familial hypercholesterolemia - heterozygous indication 238079002
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006
Familial type 3 hyperlipoproteinemia indication 398796005 DOID:3145
Slow Progression of Coronary Artery Disease indication
Primary Prevention of Coronary Heart Disease indication
Myocardial Infarction Prevention indication
Prevention of Transient Ischemic Attacks off-label use
Alcoholism contraindication 7200002
Hypothyroidism contraindication 40930008 DOID:1459
Low blood pressure contraindication 45007003
Hepatic failure contraindication 59927004
Chronic idiopathic constipation contraindication 82934008
Kidney disease contraindication 90708001 DOID:557
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hemorrhagic cerebral infarction contraindication 230706003
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Pregnancy, function contraindication 289908002
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Traumatic injury contraindication 417746004
Severe Aortic Valve Stenosis contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.44 acidic
pKa2 11.82 acidic
pKa3 13.63 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme INHIBITOR IC50 8 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme IC50 5.29 CHEMBL
Histone deacetylase 2 Enzyme IC50 4.65 CHEMBL
Histone deacetylase 1 Enzyme IC50 4.93 CHEMBL
Histone deacetylase 6 Enzyme IC50 4.84 CHEMBL
Nuclear receptor subfamily 1 group I member 3 Nuclear hormone receptor WOMBAT-PK
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 8.42 CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 4.49 CHEMBL

External reference:

IDSource
4024041 VUID
N0000022046 NUI
D00887 KEGG_DRUG
134523-03-8 SECONDARY_CAS_RN
344423-98-9 SECONDARY_CAS_RN
1297766 RXNORM
4020999 VANDF
4024041 VANDF
C0286651 UMLSCUI
CHEBI:39548 CHEBI
117 PDB_CHEM_ID
CHEMBL1487 ChEMBL_ID
CHEMBL393220 ChEMBL_ID
CHEMBL1790017 ChEMBL_ID
D000069059 MESH_DESCRIPTOR_UI
DB01076 DRUGBANK_ID
2949 IUPHAR_LIGAND_ID
7259 INN_ID
A0JWA85V8F UNII
60823 PUBCHEM_CID
186242 MMSL
34584 MMSL
4226 MMSL
d04105 MMSL
006321 NDDF
006322 NDDF
108600003 SNOMEDCT_US
108601004 SNOMEDCT_US
373444002 SNOMEDCT_US
725658002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2270 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2270 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2270 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2960 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2970 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2980 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-6180 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-6180 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-6323 TABLET, FILM COATED 20 mg ORAL NDA 32 sections