atorvastatin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperlipidaemic substances, HMG CoA reductase inhibitors 257 134523-00-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • CI-981
  • CI981
  • atorvastatin calcium hydrate
  • atorvastatin calcium anhydrous
  • atorvastatin
  • atorvastatin acid
  • cardyl
  • atorvastatin calcium
  • atorvastatin calcium trihydrate
A pyrrole and heptanoic acid derivative, HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITOR (statin), and ANTICHOLESTEREMIC AGENT that is used to reduce serum levels of LDL-CHOLESTEROL; APOLIPOPROTEIN B; and TRIGLYCERIDES. It is used to increase serum levels of HDL-CHOLESTEROL in the treatment of HYPERLIPIDEMIAS, and for the prevention of CARDIOVASCULAR DISEASES in patients with multiple risk factors.
  • Molecular weight: 558.65
  • Formula: C33H35FN2O5
  • CLOGP: 4.46
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 4
  • TPSA: 111.79
  • ALOGS: -5.95
  • ROTB: 12
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.05 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ
S (Water solubility) 0.02 mg/mL Hosey CM, Chan R, Benet LZ
EoM (Fraction excreted unchanged in urine) 1 % Hosey CM, Chan R, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Dec. 17, 1996 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 1158.18 9.67 2569 331038 130922 52884537
Rhabdomyolysis 848.34 9.67 1202 332405 42721 52972738
Maternal exposure during pregnancy 755.77 9.67 57 333550 155582 52859877
Immune-mediated myositis 719.13 9.67 268 333339 838 53014621
Rheumatoid arthritis 616.62 9.67 635 332972 313896 52701563
Drug ineffective 609.83 9.67 2840 330767 814405 52201054
Pemphigus 583.40 9.67 14 333593 104017 52911442
Exposure during pregnancy 528.48 9.67 76 333531 124784 52890675
Acute kidney injury 478.27 9.67 2966 330641 250902 52764557
Systemic lupus erythematosus 449.15 9.67 115 333492 125299 52890160
Hand deformity 432.67 9.67 24 333583 84825 52930634
Contraindicated product administered 432.11 9.67 154 333453 135475 52879984
Myopathy 421.28 9.67 403 333204 9289 53006170
Glossodynia 410.77 9.67 67 333540 100224 52915235
Cerebrovascular accident 397.15 9.67 1502 332105 103672 52911787
Treatment failure 396.93 9.67 153 333454 128250 52887209
Myocardial infarction 381.03 9.67 1426 332181 97928 52917531
Blood creatine phosphokinase increased 373.26 9.67 659 332948 28326 52987133
Off label use 345.13 9.67 1650 331957 470562 52544897
Synovitis 336.04 9.67 127 333480 107766 52907693
Anti-cyclic citrullinated peptide antibody positive 335.73 9.67 4 333603 57168 52958291
Therapeutic product effect decreased 293.90 9.67 214 333393 125441 52890018
Infusion related reaction 290.46 9.67 328 333279 155629 52859830
Muscular weakness 269.32 9.67 1298 332309 99694 52915765
Completed suicide 258.04 9.67 290 333317 137911 52877548
Acute myocardial infarction 255.97 9.67 611 332996 32624 52982835
Wound 242.77 9.67 135 333472 91422 52924037
Necrotising myositis 238.63 9.67 89 333518 279 53015180
Drug interaction 237.45 9.67 2252 331355 217077 52798382
Pericarditis 236.44 9.67 56 333551 64350 52951109
Rheumatoid factor positive 233.01 9.67 5 333602 41193 52974266
Arthropathy 213.28 9.67 347 333260 141106 52874353
Drug intolerance 209.46 9.67 626 332981 204867 52810592
Drug hypersensitivity 206.58 9.67 2550 331057 262692 52752767
Product use issue 191.76 9.67 363 333244 139221 52876238
Coronary artery disease 189.26 9.67 548 333059 32889 52982570
Pain 182.94 9.67 2587 331020 585811 52429648
Hypomagnesaemia 179.16 9.67 445 333162 24366 52991093
Alopecia 178.91 9.67 806 332801 233777 52781682
Muscle spasms 176.24 9.67 1443 332164 133352 52882107
Duodenal ulcer perforation 170.30 9.67 13 333594 35170 52980289
Swelling 166.06 9.67 624 332983 190481 52824978
Hypersensitivity 161.10 9.67 723 332884 209942 52805517
Abdominal discomfort 158.86 9.67 776 332831 220286 52795173
Joint swelling 156.56 9.67 845 332762 233793 52781666
Discomfort 153.64 9.67 224 333383 95248 52920211
Foetal exposure during pregnancy 151.86 9.67 19 333588 34696 52980763
Polymyositis 151.73 9.67 109 333498 1655 53013804
Febrile neutropenia 147.54 9.67 269 333338 104667 52910792
Fall 147.51 9.67 3099 330508 355341 52660118
Lactic acidosis 142.90 9.67 535 333072 36718 52978741
Blood glucose increased 142.75 9.67 900 332707 76461 52938998
Folliculitis 139.57 9.67 17 333590 31692 52983767
Helicobacter infection 137.54 9.67 37 333570 39032 52976427
Hypoglycaemia 137.21 9.67 730 332877 58283 52957176
Hyperkalaemia 133.63 9.67 682 332925 53574 52961885
Transient ischaemic attack 132.03 9.67 507 333100 35218 52980241
Myositis 130.66 9.67 209 333398 8274 53007185
Abortion spontaneous 129.13 9.67 65 333542 46570 52968889
Device expulsion 128.76 9.67 17 333590 29796 52985663
Toxicity to various agents 128.31 9.67 825 332782 218773 52796686
Pregnancy 126.47 9.67 22 333585 31419 52984040
Rash 124.86 9.67 2001 331606 444190 52571269
Infection 123.94 9.67 604 333003 171601 52843858
Chest pain 122.00 9.67 1766 331841 188419 52827040
Hyponatraemia 117.22 9.67 1115 332492 107492 52907967
Drug abuse 115.27 9.67 144 333463 65382 52950077
Low density lipoprotein increased 114.91 9.67 166 333441 6000 53009459
Liver function test abnormal 111.30 9.67 594 333013 47477 52967982
Sinusitis 109.09 9.67 613 332994 167951 52847508
Angina pectoris 108.07 9.67 410 333197 28315 52987144
Ischaemic stroke 107.76 9.67 301 333306 17692 52997767
Atrial fibrillation 104.93 9.67 1114 332493 110538 52904921
Sleep disorder due to general medical condition, insomnia type 104.88 9.67 14 333593 24335 52991124
Cardiac failure congestive 103.94 9.67 960 332647 91797 52923662
Stomatitis 102.08 9.67 296 333311 97862 52917597
Hypertensive emergency 101.43 9.67 85 333522 1636 53013823
Angina unstable 97.67 9.67 171 333436 7297 53008162
Cholestasis 96.19 9.67 395 333212 28300 52987159
Neurologic neglect syndrome 95.14 9.67 70 333537 1105 53014354
Malignant neoplasm progression 94.76 9.67 190 333417 71351 52944108
Carotid artery thrombosis 94.40 9.67 71 333536 1161 53014298
Impaired healing 94.38 9.67 160 333447 64045 52951414
Pyrexia 93.71 9.67 1868 331739 401325 52614134
Autoimmune hepatitis 93.02 9.67 178 333429 8140 53007319
Irritable bowel syndrome 92.32 9.67 82 333525 43550 52971909
Hemiplegia 91.05 9.67 170 333437 7630 53007829
Gastrointestinal haemorrhage 88.79 9.67 829 332778 79501 52935958
Diabetic ketoacidosis 87.46 9.67 299 333308 19616 52995843
Drug-induced liver injury 86.87 9.67 388 333219 28845 52986614
Premature baby 86.21 9.67 11 333596 19790 52995669
Asthenia 85.96 9.67 2782 330825 340808 52674651
Neutropenia 85.95 9.67 612 332995 158573 52856886
Premature delivery 85.90 9.67 28 333579 26076 52989383
Syncope 84.50 9.67 1071 332536 110922 52904537
Intentional overdose 84.37 9.67 184 333423 67021 52948438
Caesarean section 82.15 9.67 7 333600 17313 52998146
Renal failure 79.92 9.67 1110 332497 117342 52898117
Coronary artery occlusion 79.10 9.67 166 333441 8121 53007338
Dizziness 76.46 9.67 2947 330660 369312 52646147
International normalised ratio increased 76.21 9.67 536 333071 47225 52968234
Bradycardia 71.49 9.67 719 332888 70337 52945122
Blood cholesterol increased 71.18 9.67 571 333036 52418 52963041
Pancreatitis acute 70.54 9.67 337 333270 25772 52989687
Muscle injury 70.44 9.67 50 333557 29716 52985743
Myocardial ischaemia 68.37 9.67 206 333401 12638 53002821
Live birth 66.45 9.67 8 333599 15051 53000408
Hepatitis cholestatic 66.36 9.67 141 333466 6958 53008501
Melaena 66.10 9.67 358 333249 28771 52986688
Intentional self-injury 65.95 9.67 38 333569 25246 52990213
Glycosylated haemoglobin increased 65.92 9.67 191 333416 11464 53003995
Ill-defined disorder 65.74 9.67 131 333476 49313 52966146
Cerebral haemorrhage 65.61 9.67 365 333242 29631 52985828
Product use in unapproved indication 65.42 9.67 422 333185 111867 52903592
Adjustment disorder 65.34 9.67 70 333537 1853 53013606
Hepatic enzyme increased 65.29 9.67 491 333116 125704 52889755
Rectal haemorrhage 64.71 9.67 463 333144 41018 52974441
Hepatitis 64.15 9.67 397 333210 33497 52981962
Condition aggravated 62.66 9.67 1398 332209 295736 52719723
C-reactive protein increased 62.63 9.67 216 333391 67670 52947789
Intentional product use issue 62.04 9.67 238 333369 72256 52943203
Acute coronary syndrome 62.04 9.67 174 333433 10250 53005209
Muscle necrosis 62.00 9.67 41 333566 540 53014919
Diabetes mellitus 60.94 9.67 559 333048 53340 52962119
Pemphigoid 60.25 9.67 128 333479 6316 53009143
Rheumatic fever 60.04 9.67 5 333602 12599 53002860
Anaemia 58.96 9.67 2200 331407 274518 52740941
Decreased appetite 58.51 9.67 1759 331848 213215 52802244
Swollen joint count increased 58.13 9.67 3 333604 11287 53004172
Incorrect dosage administered 57.54 9.67 64 333543 1769 53013690
Blood triglycerides increased 57.47 9.67 190 333417 12251 53003208
Infective pulmonary exacerbation of cystic fibrosis 57.33 9.67 3 333604 11153 53004306
Coronary artery stenosis 56.84 9.67 106 333501 4753 53010706
Labelled drug-drug interaction medication error 56.32 9.67 173 333434 10726 53004733
Atrioventricular block 55.75 9.67 132 333475 7008 53008451
Cardiac disorder 55.08 9.67 491 333116 46475 52968984
Amnesia 54.95 9.67 477 333130 44811 52970648
Device dislocation 54.07 9.67 41 333566 23556 52991903
Renal impairment 53.46 9.67 774 332833 82544 52932915
Hepatitis acute 52.25 9.67 148 333459 8768 53006691
Injection site reaction 51.94 9.67 156 333451 51010 52964449
Atrioventricular block complete 51.90 9.67 138 333469 7877 53007582
Hepatocellular injury 51.68 9.67 343 333264 29643 52985816
Leukopenia 51.45 9.67 260 333347 73203 52942256
Chromaturia 51.44 9.67 217 333390 15733 52999726
Nasopharyngitis 51.40 9.67 869 332738 191426 52824033
Drug resistance 50.66 9.67 31 333576 19931 52995528
Gastrointestinal disorder 50.03 9.67 343 333264 89661 52925798
Haematochezia 48.74 9.67 441 333166 41917 52973542
Injection site erythema 48.27 9.67 284 333323 76965 52938494
Hip arthroplasty 48.19 9.67 62 333545 27800 52987659
Personality disorder 48.18 9.67 90 333517 4041 53011418
Suicide attempt 47.21 9.67 195 333412 57973 52957486
Knee arthroplasty 47.20 9.67 86 333521 33483 52981976
Chronic kidney disease 47.11 9.67 446 333161 42924 52972535
Jaundice 47.08 9.67 338 333269 29975 52985484
Oedema peripheral 46.59 9.67 1398 332209 169389 52846070
Autoimmune myositis 46.56 9.67 18 333589 64 53015395
Swollen tongue 46.23 9.67 343 333264 30737 52984722
High density lipoprotein decreased 46.21 9.67 58 333549 1827 53013632
Therapeutic product effect incomplete 46.10 9.67 360 333247 91424 52924035
Dysarthria 45.48 9.67 420 333187 40148 52975311
Pain in extremity 45.31 9.67 2198 331409 282852 52732607
Premature labour 44.86 9.67 11 333596 12351 53003108
Cardiac failure 44.67 9.67 770 332837 85074 52930385
Carotid arteriosclerosis 44.48 9.67 43 333564 1004 53014455
Blood alkaline phosphatase increased 44.26 9.67 424 333183 40938 52974521
Mixed liver injury 43.78 9.67 84 333523 3849 53011610
Hemiparesis 43.48 9.67 256 333351 21219 52994240
Cytomegalovirus infection 43.44 9.67 35 333572 19504 52995955
Injection site swelling 43.24 9.67 130 333477 42498 52972961
Neurotoxicity 43.08 9.67 21 333586 15328 53000131
Product substitution issue 43.01 9.67 205 333402 15661 52999798
Injection site pain 42.65 9.67 478 333129 112913 52902546
Coma 42.51 9.67 220 333387 61563 52953896
Bone erosion 42.32 9.67 9 333598 11143 53004316
Labile blood pressure 41.76 9.67 55 333552 1819 53013640
Red blood cell sedimentation rate abnormal 41.75 9.67 23 333584 15666 52999793
Muscle atrophy 41.53 9.67 110 333497 6264 53009195
Diabetes mellitus inadequate control 41.07 9.67 188 333419 14122 53001337
Hyperlipidaemia 41.05 9.67 235 333372 19280 52996179
Confusional state 40.57 9.67 1541 332066 192680 52822779
Pancytopenia 40.55 9.67 368 333239 90560 52924899
Vascular stent stenosis 40.40 9.67 31 333576 523 53014936
Carotid artery stenosis 39.99 9.67 97 333510 5230 53010229
Accidental exposure to product 39.60 9.67 54 333553 23620 52991839
Mucosal inflammation 38.87 9.67 137 333470 42647 52972812
Gestational diabetes 38.82 9.67 3 333604 8036 53007423
Large intestine polyp 38.61 9.67 125 333482 7972 53007487
Abortion induced 38.58 9.67 10 333597 10816 53004643
Polymyalgia rheumatica 38.47 9.67 65 333542 2694 53012765
Psoriatic arthropathy 38.21 9.67 163 333444 48027 52967432
Musculoskeletal stiffness 37.85 9.67 543 333064 122825 52892634
Dehydration 37.78 9.67 1347 332260 167063 52848396
Blood loss anaemia 37.46 9.67 131 333476 8692 53006767
Hepatitis toxic 37.34 9.67 69 333538 3072 53012387
Muscle disorder 37.19 9.67 86 333521 4495 53010964
Pre-eclampsia 37.17 9.67 5 333602 8642 53006817
Hypocalcaemia 37.16 9.67 312 333295 29025 52986434
Hyperglycaemia 36.71 9.67 398 333209 39686 52975773
Macular degeneration 36.67 9.67 164 333443 12197 53003262
Blister 36.31 9.67 316 333291 78437 52937022
Death 36.04 9.67 1846 331761 355386 52660073
Migraine 35.62 9.67 326 333281 80091 52935368
Gait disturbance 35.51 9.67 1270 332337 157572 52857887
Arterial stenosis 35.31 9.67 31 333576 637 53014822
Respiratory depression 35.22 9.67 18 333589 12788 53002671
Uterine perforation 35.18 9.67 3 333604 7416 53008043
Haemorrhage intracranial 35.09 9.67 171 333436 13181 53002278
Sensory loss 34.98 9.67 119 333488 7786 53007673
Neutrophil count decreased 34.81 9.67 173 333434 48925 52966534
Low density lipoprotein abnormal 34.76 9.67 19 333588 172 53015287
Blood cholesterol abnormal 34.62 9.67 59 333548 2463 53012996
Respiratory arrest 33.51 9.67 103 333504 33437 52982022
Gamma-glutamyltransferase increased 33.48 9.67 339 333268 33216 52982243
Product monitoring error 33.33 9.67 63 333544 2854 53012605
Disease progression 33.26 9.67 443 333164 101477 52913982
Therapeutic response decreased 32.94 9.67 169 333438 47400 52968059
Haematoma 32.85 9.67 340 333267 33504 52981955
Blood pressure increased 32.84 9.67 1129 332478 139350 52876109
Myelosuppression 32.44 9.67 20 333587 12808 53002651
Peripheral artery stenosis 32.11 9.67 28 333579 570 53014889
Dyspnoea 31.76 9.67 4156 329451 582076 52433383
Lower respiratory tract infection 31.71 9.67 390 333217 90591 52924868
Blood glucose decreased 31.55 9.67 224 333383 19792 52995667
Aphasia 31.21 9.67 312 333295 30466 52984993
Myocardial necrosis marker increased 31.07 9.67 45 333562 1630 53013829
Upper gastrointestinal haemorrhage 31.02 9.67 201 333406 17229 52998230
Amenorrhoea 30.81 9.67 10 333597 9339 53006120
Foetal death 30.80 9.67 10 333597 9337 53006122
Inappropriate antidiuretic hormone secretion 30.12 9.67 178 333429 14773 53000686
Body height decreased 30.01 9.67 132 333475 9747 53005712
Device issue 29.99 9.67 56 333551 21602 52993857
Subdural haematoma 29.49 9.67 167 333440 13646 53001813
Ischaemic cardiomyopathy 29.40 9.67 56 333551 2552 53012907
Myoglobin blood increased 29.28 9.67 41 333566 1439 53014020
Blood creatine phosphokinase MB increased 29.06 9.67 38 333569 1248 53014211
Stillbirth 29.05 9.67 4 333603 6793 53008666
Febrile bone marrow aplasia 28.98 9.67 5 333602 7184 53008275
Mitral valve incompetence 28.64 9.67 215 333392 19336 52996123
Angioedema 28.63 9.67 395 333212 41681 52973778
Alanine aminotransferase increased 28.55 9.67 788 332819 94307 52921152
Dementia 28.50 9.67 191 333416 16559 52998900
Orthostatic hypotension 28.45 9.67 298 333309 29455 52986004
Euglycaemic diabetic ketoacidosis 28.42 9.67 60 333547 2947 53012512
Cholestatic liver injury 28.09 9.67 53 333554 2398 53013061
Aldolase increased 28.00 9.67 15 333592 130 53015329
Myopathy toxic 27.76 9.67 22 333585 390 53015069
Myoglobinuria 27.75 9.67 18 333589 229 53015230
Eating disorder 27.74 9.67 185 333422 16012 52999447
Cell death 27.72 9.67 53 333554 2422 53013037
Oligohydramnios 27.38 9.67 3 333604 6073 53009386
Cerebral infarction 27.36 9.67 253 333354 24191 52991268
Seizure 27.04 9.67 610 332997 128899 52886560
Aortic stenosis 26.99 9.67 76 333531 4487 53010972
Arteriosclerosis 26.94 9.67 130 333477 9981 53005478
Metastases to bone 26.74 9.67 50 333557 19278 52996181
Weight decreased 26.64 9.67 1757 331850 233191 52782268
Stent placement 26.59 9.67 65 333542 3522 53011937
Panniculitis 26.39 9.67 8 333599 7806 53007653
Dermatomyositis 26.11 9.67 51 333556 2368 53013091
Acute myeloid leukaemia 25.99 9.67 41 333566 16891 52998568
Heavy menstrual bleeding 25.80 9.67 43 333564 17333 52998126
Urine output decreased 25.79 9.67 142 333465 11481 53003978
Head injury 25.77 9.67 261 333346 25572 52989887
Device related infection 25.70 9.67 66 333541 22720 52992739
Haematemesis 25.37 9.67 300 333307 30557 52984902
Aspartate aminotransferase increased 25.13 9.67 696 332911 83333 52932126
Faeces discoloured 25.07 9.67 193 333414 17493 52997966
Diabetic metabolic decompensation 24.92 9.67 40 333567 1588 53013871
Flatulence 24.85 9.67 304 333303 31213 52984246
Traumatic coma 24.61 9.67 11 333596 61 53015398
Lichen planopilaris 24.49 9.67 6 333601 0 53015459
Maternal drugs affecting foetus 24.34 9.67 3 333604 5543 53009916
Renal disorder 24.27 9.67 284 333323 28855 52986604
Subarachnoid haemorrhage 24.22 9.67 142 333465 11751 53003708
Embolic stroke 24.18 9.67 65 333542 3734 53011725
Gynaecomastia 24.10 9.67 14 333593 144 53015315
Intestinal haemorrhage 24.09 9.67 61 333546 3379 53012080
Hypercholesterolaemia 23.96 9.67 148 333459 12478 53002981
Anuria 23.72 9.67 146 333461 12294 53003165
Diabetic nephropathy 23.59 9.67 37 333570 1440 53014019
Diabetic retinopathy 23.54 9.67 49 333558 2383 53013076
Mouth swelling 23.52 9.67 70 333537 4265 53011194
Balance disorder 23.50 9.67 612 332995 72595 52942864
Pathogen resistance 23.49 9.67 6 333601 6554 53008905
Blood creatinine increased 23.42 9.67 680 332927 81982 52933477
Haematotoxicity 23.41 9.67 10 333597 7887 53007572
Subacute cutaneous lupus erythematosus 23.26 9.67 48 333559 2320 53013139
Incorrect route of product administration 23.07 9.67 54 333553 19190 52996269
Ankylosing spondylitis 22.98 9.67 11 333596 8114 53007345
Hypokalaemia 22.88 9.67 777 332830 95740 52919719
Hypovolaemic shock 22.82 9.67 82 333525 5515 53009944
Carotid artery occlusion 22.75 9.67 52 333555 2697 53012762
Chronic obstructive pulmonary disease 22.75 9.67 521 333086 60552 52954907
Liver disorder 22.65 9.67 365 333242 39790 52975669
Fibromyalgia 22.53 9.67 172 333435 43903 52971556
Hepatic ischaemia 22.44 9.67 24 333583 634 53014825
Hypovolaemia 22.36 9.67 126 333481 10276 53005183
Injection site pruritus 22.36 9.67 160 333447 41429 52974030
Coronary artery thrombosis 22.17 9.67 33 333574 1226 53014233
Haemophagocytic lymphohistiocytosis 22.08 9.67 15 333592 9122 53006337
Rheumatoid nodule 22.00 9.67 25 333582 11839 53003620
Suicidal ideation 21.99 9.67 257 333350 60254 52955205
Mydriasis 21.96 9.67 23 333584 11303 53004156
Malaise 21.86 9.67 2555 331052 355062 52660397
Pallor 21.67 9.67 247 333360 24935 52990524
Transplant rejection 21.56 9.67 19 333588 10132 53005327
Motor dysfunction 21.48 9.67 106 333501 8212 53007247
Metastases to liver 21.48 9.67 66 333541 21430 52994029
Thrombocytopenia 21.47 9.67 682 332925 138045 52877414
Enthesopathy 21.39 9.67 7 333600 6504 53008955
Presyncope 21.24 9.67 254 333353 25940 52989519
Affect lability 21.11 9.67 115 333492 9260 53006199
Multiple sclerosis relapse 21.10 9.67 179 333428 44674 52970785
Eosinophilia 21.02 9.67 215 333392 21120 52994339
Cardiac murmur 20.97 9.67 137 333470 11776 53003683
Ocular myasthenia 20.90 9.67 13 333594 153 53015306
Psychotic disorder 20.89 9.67 80 333527 24305 52991154
Retinal artery occlusion 20.68 9.67 37 333570 1606 53013853
Hepatic function abnormal 20.66 9.67 335 333272 36564 52978895
Coronary artery bypass 20.65 9.67 47 333560 2431 53013028
Tenosynovitis 20.64 9.67 19 333588 9920 53005539
Complication of device insertion 20.61 9.67 6 333601 6011 53009448
Antimitochondrial antibody positive 20.57 9.67 10 333597 69 53015390
Food allergy 20.52 9.67 13 333594 8205 53007254
Immunodeficiency 20.46 9.67 39 333568 14928 53000531
Blood creatine phosphokinase abnormal 20.43 9.67 15 333592 236 53015223
Overdose 20.40 9.67 515 333092 107221 52908238
Dysphagia 20.40 9.67 681 332926 83716 52931743
Lymphocyte count decreased 20.37 9.67 98 333509 27954 52987505
Acne 20.37 9.67 68 333539 21518 52993941
Peripheral nerve palsy 20.34 9.67 7 333600 16 53015443
Candida infection 20.33 9.67 85 333522 25188 52990271
Cerebral haematoma 20.27 9.67 58 333549 3456 53012003
Extraocular muscle paresis 20.27 9.67 13 333594 162 53015297
Duodenal ulcer 20.22 9.67 98 333509 7538 53007921
Stevens-Johnson syndrome 20.20 9.67 82 333525 24500 52990959
Glomerular filtration rate decreased 20.19 9.67 143 333464 12624 53002835
Therapeutic drug monitoring analysis not performed 20.00 9.67 24 333583 721 53014738
Chloropsia 19.97 9.67 8 333599 32 53015427
Sinus bradycardia 19.96 9.67 158 333449 14443 53001016
Pulmonary renal syndrome 19.95 9.67 18 333589 384 53015075
Pancreatitis 19.87 9.67 402 333205 45740 52969719
Cerebral microangiopathy 19.85 9.67 15 333592 247 53015212
Bone marrow failure 19.73 9.67 109 333498 30006 52985453
Hepatic steatosis 19.73 9.67 251 333356 26008 52989451
Peripheral arterial occlusive disease 19.72 9.67 62 333545 3892 53011567
Metastases to central nervous system 19.66 9.67 28 333579 12029 53003430
Hypertensive cardiomyopathy 19.60 9.67 15 333592 252 53015207
Dyslipidaemia 19.57 9.67 85 333522 6242 53009217
Grip strength decreased 19.45 9.67 27 333580 11722 53003737
Cervix neoplasm 19.35 9.67 14 333593 215 53015244
Urinary tract obstruction 19.22 9.67 39 333568 1862 53013597
Hypertransaminasaemia 19.15 9.67 62 333545 3954 53011505
Unintentional medical device removal 19.14 9.67 5 333602 5381 53010078
Gastric ulcer 19.12 9.67 227 333380 23142 52992317
Dysstasia 19.07 9.67 193 333414 18906 52996553
Memory impairment 19.00 9.67 678 332929 84079 52931380
Loss of personal independence in daily activities 18.79 9.67 315 333292 69500 52945959
Tuberculosis 18.77 9.67 25 333582 11046 53004413
Urinary tract discomfort 18.63 9.67 13 333594 188 53015271
Aspergillus infection 18.53 9.67 12 333595 7484 53007975
Periorbital haematoma 18.52 9.67 24 333583 781 53014678
Ascites 18.50 9.67 159 333448 39576 52975883
Arteriovenous fistula occlusion 18.34 9.67 17 333590 376 53015083
Left atrial enlargement 18.28 9.67 15 333592 280 53015179
Epstein-Barr virus infection 18.16 9.67 12 333595 7406 53008053
Eructation 18.13 9.67 97 333510 7758 53007701
Arterial occlusive disease 18.11 9.67 71 333536 4978 53010481
Abnormal dreams 18.11 9.67 121 333486 10480 53004979
Diverticulum 18.09 9.67 131 333476 11648 53003811
Lipids abnormal 18.02 9.67 15 333592 286 53015173
Gastrointestinal toxicity 17.93 9.67 68 333539 4694 53010765
Menstruation irregular 17.89 9.67 11 333596 7055 53008404
Rectal polyp 17.74 9.67 26 333581 952 53014507
Poisoning deliberate 17.69 9.67 17 333590 8696 53006763
Hallucination, gustatory 17.62 9.67 9 333598 70 53015389
Cardiotoxicity 17.61 9.67 12 333595 7287 53008172
Cardiac failure acute 17.52 9.67 107 333500 8985 53006474
Haematuria 17.52 9.67 262 333345 28127 52987332
Calcium deficiency 17.40 9.67 26 333581 969 53014490
Blood urea increased 17.34 9.67 245 333362 25986 52989473
Poisoning 17.31 9.67 38 333569 13812 53001647
Low birth weight baby 17.29 9.67 9 333598 6328 53009131
Intermittent claudication 17.23 9.67 37 333570 1839 53013620
Lower gastrointestinal haemorrhage 17.17 9.67 93 333514 7473 53007986
Angiopathy 17.10 9.67 64 333543 4390 53011069
Coronary artery restenosis 17.07 9.67 17 333590 412 53015047
Electrocardiogram abnormal 17.03 9.67 98 333509 8055 53007404
Sedation 17.02 9.67 112 333495 29563 52985896
Device difficult to use 16.95 9.67 24 333583 10335 53005124
Breast cancer metastatic 16.83 9.67 45 333562 15283 53000176
Menstrual disorder 16.82 9.67 4 333603 4586 53010873
Blood pressure inadequately controlled 16.77 9.67 68 333539 4843 53010616
Epistaxis 16.75 9.67 555 333052 68155 52947304
Apolipoprotein A-I decreased 16.74 9.67 7 333600 32 53015427
White blood cell count decreased 16.69 9.67 623 332984 123852 52891607
Heart injury 16.67 9.67 28 333579 1155 53014304
Albuminuria 16.66 9.67 13 333594 225 53015234
Hypophagia 16.65 9.67 280 333327 30782 52984677
Dysgeusia 16.54 9.67 368 333239 42563 52972896
Spur cell anaemia 16.53 9.67 6 333601 17 53015442
Inclusion body myositis 16.50 9.67 5 333602 6 53015453
Haemorrhagic transformation stroke 16.41 9.67 28 333579 1170 53014289
Muscle relaxant therapy 16.33 9.67 12 333595 189 53015270
Cholangiolitis 16.32 9.67 4 333603 0 53015459
Post viral fatigue syndrome 16.25 9.67 11 333596 151 53015308
Normochromic normocytic anaemia 16.24 9.67 65 333542 4601 53010858
No adverse event 16.18 9.67 162 333445 39103 52976356
Hepatorenal syndrome 16.17 9.67 38 333569 2007 53013452
Lipoprotein (a) increased 16.08 9.67 7 333600 36 53015423
Flushing 16.05 9.67 328 333279 70272 52945187
Interstitial lung disease 15.99 9.67 480 333127 58142 52957317
Mobility decreased 15.98 9.67 359 333248 75912 52939547
Palmar-plantar erythrodysaesthesia syndrome 15.97 9.67 75 333532 21531 52993928
Blood creatinine abnormal 15.90 9.67 46 333561 2758 53012701
Immune reconstitution inflammatory syndrome 15.90 9.67 10 333597 6336 53009123
Pelvic pain 15.90 9.67 33 333574 12240 53003219
Diverticulum intestinal 15.84 9.67 82 333525 6475 53008984
Acute pulmonary oedema 15.81 9.67 97 333510 8158 53007301
Abnormal loss of weight 15.73 9.67 71 333536 5301 53010158
Cardiac discomfort 15.68 9.67 23 333584 843 53014616
Neoplasm progression 15.65 9.67 116 333491 29803 52985656
Plasma cell myeloma 15.64 9.67 208 333399 47666 52967793
Headache 15.60 9.67 3040 330567 533781 52481678
Pulmonary toxicity 15.60 9.67 71 333536 5320 53010139
Chest wall haematoma 15.59 9.67 11 333596 162 53015297
Ventricular septal defect 15.54 9.67 4 333603 4346 53011113
Blue toe syndrome 15.44 9.67 16 333591 407 53015052
Electrocardiogram QT prolonged 15.43 9.67 462 333145 55941 52959518
Spinal epidural haematoma 15.38 9.67 23 333584 858 53014601
Bacteraemia 15.35 9.67 48 333559 15501 52999958
Hepatic cytolysis 15.32 9.67 93 333514 7792 53007667
Tongue oedema 15.30 9.67 60 333547 4207 53011252
Tumour lysis syndrome 15.26 9.67 16 333591 7858 53007601
Lip swelling 15.24 9.67 247 333360 26954 52988505
Cerebral ischaemia 15.17 9.67 82 333525 6583 53008876
Procedural hypertension 15.14 9.67 13 333594 259 53015200
Saliva altered 15.09 9.67 14 333593 310 53015149
Fatigue 15.03 9.67 4205 329402 726301 52289158
Microcytic anaemia 15.02 9.67 51 333556 3334 53012125
Inflammation 14.98 9.67 259 333348 56877 52958582
Blood electrolytes abnormal 14.97 9.67 25 333582 1026 53014433
Quadriplegia 14.97 9.67 35 333572 1843 53013616
Aplastic anaemia 14.93 9.67 18 333589 8303 53007156
Arthralgia 14.89 9.67 2470 331137 437313 52578146
Oral herpes 14.80 9.67 75 333532 21104 52994355
Ear infection 14.73 9.67 98 333509 25802 52989657
Carotid artery disease 14.69 9.67 33 333574 1692 53013767
Staphylococcal infection 14.68 9.67 162 333445 38386 52977073
IIIrd nerve paresis 14.67 9.67 10 333597 139 53015320
Fear of eating 14.59 9.67 15 333592 378 53015081
Fungal infection 14.59 9.67 130 333477 32116 52983343
Ecchymosis 14.57 9.67 119 333488 10980 53004479
Coordination abnormal 14.55 9.67 126 333481 11825 53003634
Unintended pregnancy 14.54 9.67 10 333597 6043 53009416
Transaminases increased 14.50 9.67 267 333340 29865 52985594
Vascular stent occlusion 14.44 9.67 7 333600 48 53015411
Urinary occult blood positive 14.44 9.67 7 333600 48 53015411
Vascular stenosis 14.38 9.67 13 333594 278 53015181
Ventricular hypertrophy 14.37 9.67 54 333553 3711 53011748
Arterial insufficiency 14.31 9.67 10 333597 145 53015314
Bronchopulmonary aspergillosis 14.25 9.67 20 333587 8645 53006814
Large intestinal haemorrhage 14.19 9.67 27 333580 1229 53014230
Cytokine release syndrome 14.15 9.67 18 333589 8111 53007348
Ketoacidosis 14.10 9.67 60 333547 4366 53011093
Adverse drug reaction 14.08 9.67 243 333364 53382 52962077
Prothrombin consumption time prolonged 14.08 9.67 7 333600 51 53015408
Myelodysplastic syndrome 14.05 9.67 55 333552 16605 52998854
Blood lactic acid 14.04 9.67 9 333598 112 53015347
Asthma 14.04 9.67 548 333059 108424 52907035
Acute left ventricular failure 14.01 9.67 22 333585 857 53014602
Electrolyte imbalance 13.97 9.67 180 333427 18704 52996755
Muscle fatigue 13.94 9.67 39 333568 2294 53013165
Vertigo 13.93 9.67 454 333153 55627 52959832
Acute respiratory distress syndrome 13.93 9.67 87 333520 23245 52992214
Jaundice hepatocellular 13.92 9.67 6 333601 30 53015429
Cholecystitis chronic 13.86 9.67 28 333579 10490 53004969
Glomerular filtration rate abnormal 13.86 9.67 18 333589 587 53014872
Percutaneous coronary intervention 13.85 9.67 10 333597 153 53015306
Device adhesion issue 13.85 9.67 3 333604 3667 53011792
Device deployment issue 13.81 9.67 3 333604 3661 53011798
Injection site rash 13.81 9.67 55 333552 16524 52998935
Peripheral vascular disorder 13.81 9.67 75 333532 6033 53009426
Disorientation 13.80 9.67 333 333274 39026 52976433
Neurosensory hypoacusis 13.71 9.67 13 333594 296 53015163
Muscle enzyme increased 13.64 9.67 9 333598 118 53015341
Biliary fibrosis 13.58 9.67 4 333603 4 53015455
Copper metabolism disorder 13.58 9.67 4 333603 4 53015455
Cardiac operation 13.56 9.67 44 333563 2809 53012650
Cardiac valve disease 13.46 9.67 58 333549 4244 53011215
Coronary artery surgery 13.43 9.67 7 333600 57 53015402
Colitis ischaemic 13.43 9.67 115 333492 10759 53004700
Cerebral mass effect 13.41 9.67 22 333585 890 53014569
Blood sodium decreased 13.36 9.67 211 333396 22905 52992554
Lipids increased 13.34 9.67 25 333582 1125 53014334
Polyuria 13.33 9.67 90 333517 7821 53007638
Subchondral insufficiency fracture 13.33 9.67 7 333600 58 53015401
Acidosis 13.30 9.67 119 333488 11273 53004186
Hypertensive angiopathy 13.24 9.67 8 333599 89 53015370
Complication associated with device 13.23 9.67 54 333553 16111 52999348
Jaundice cholestatic 13.22 9.67 69 333538 5465 53009994
Hypocapnia 13.21 9.67 14 333593 366 53015093
Renovascular hypertension 13.10 9.67 5 333602 17 53015442
Respiratory disorder 13.10 9.67 143 333464 33954 52981505
Thalamus haemorrhage 13.09 9.67 18 333589 621 53014838
Cardio-respiratory arrest 13.05 9.67 274 333333 58484 52956975
Progressive multifocal leukoencephalopathy 13.02 9.67 36 333571 12093 53003366
Bladder sphincter atony 13.02 9.67 10 333597 169 53015290
Cardiac pacemaker insertion 13.00 9.67 53 333554 3784 53011675
Muscle haemorrhage 12.99 9.67 49 333558 3374 53012085
Platelet count decreased 12.99 9.67 548 333059 107551 52907908
Generalised tonic-clonic seizure 12.98 9.67 116 333491 28642 52986817
Internal haemorrhage 12.96 9.67 61 333546 4635 53010824
Low density lipoprotein decreased 12.94 9.67 11 333596 216 53015243
Tubulointerstitial nephritis 12.93 9.67 159 333448 16345 52999114
Macular oedema 12.92 9.67 56 333551 4109 53011350
Blood iron decreased 12.90 9.67 125 333482 12103 53003356
Posture abnormal 12.87 9.67 38 333569 2305 53013154
High density lipoprotein abnormal 12.84 9.67 7 333600 63 53015396
Fine motor skill dysfunction 12.76 9.67 5 333602 4154 53011305
Vascular purpura 12.76 9.67 28 333579 1413 53014046
Myoglobinaemia 12.68 9.67 5 333602 19 53015440
Tubulointerstitial nephritis and uveitis syndrome 12.63 9.67 10 333597 177 53015282
Gastric ulcer haemorrhage 12.59 9.67 64 333543 5018 53010441
Nail bed inflammation 12.56 9.67 14 333593 388 53015071
Product prescribing error 12.48 9.67 208 333399 22823 52992636
Xanthelasma 12.48 9.67 7 333600 67 53015392
Blood pressure systolic increased 12.45 9.67 298 333309 34879 52980580
Glucose urine present 12.45 9.67 19 333588 722 53014737
Myasthenia gravis 12.43 9.67 53 333554 3860 53011599
Wrong dose 12.42 9.67 21 333586 871 53014588
Diverticulum oesophageal 12.40 9.67 9 333598 139 53015320
Diabetic neuropathy 12.38 9.67 54 333553 3973 53011486
Renal injury 12.37 9.67 105 333502 9799 53005660
Hypertension 12.36 9.67 1600 332007 223831 52791628
Dyspnoea exertional 12.33 9.67 440 333167 54560 52960899
BRASH syndrome 12.26 9.67 10 333597 185 53015274
Vaginal haemorrhage 12.23 9.67 108 333499 26733 52988726
Gait inability 12.21 9.67 320 333287 37991 52977468
Anal polyp 12.15 9.67 6 333601 43 53015416
Tobacco abuse 12.15 9.67 18 333589 666 53014793
Cataract 12.14 9.67 401 333206 49219 52966240
Blood calcitonin increased 12.11 9.67 5 333602 22 53015437
Gait deviation 12.05 9.67 7 333600 72 53015387
Collagen disorder 12.00 9.67 10 333597 191 53015268
Blood iron abnormal 12.00 9.67 3 333604 3324 53012135
Administration site discomfort 11.99 9.67 8 333599 107 53015352
Incision site haemorrhage 11.97 9.67 16 333591 537 53014922
Mixed anxiety and depressive disorder 11.95 9.67 10 333597 192 53015267
Urinary tract infection 11.95 9.67 1693 331914 238210 52777249
Granulomatous dermatitis 11.93 9.67 8 333599 108 53015351
Parkinsonian rest tremor 11.93 9.67 8 333599 108 53015351
Nuchal rigidity 11.88 9.67 17 333590 609 53014850
Genital haemorrhage 11.85 9.67 16 333591 7028 53008431
Renal artery stenosis 11.84 9.67 32 333575 1844 53013615
Soft tissue disorder 11.84 9.67 6 333601 4284 53011175
Arteriosclerosis coronary artery 11.84 9.67 92 333515 8362 53007097
Colitis ulcerative 11.82 9.67 80 333527 20981 52994478
Injury 11.82 9.67 236 333371 50735 52964724
Hypergammaglobulinaemia 11.82 9.67 15 333592 478 53014981
Shock haemorrhagic 11.81 9.67 98 333509 9085 53006374
Central nervous system lesion 11.80 9.67 29 333578 10133 53005326
Pollakiuria 11.76 9.67 227 333380 25612 52989847
Electrocardiogram Q wave abnormal 11.73 9.67 7 333600 76 53015383
Muscle contracture 11.72 9.67 26 333581 1322 53014137
Ligament sprain 11.71 9.67 114 333493 11052 53004407
Crystal urine 11.71 9.67 6 333601 47 53015412
Injection site warmth 11.69 9.67 47 333560 14081 53001378
Neurofibrosarcoma 11.67 9.67 9 333598 153 53015306
Adenovirus infection 11.65 9.67 3 333604 3259 53012200
Lipohypertrophy 11.62 9.67 19 333588 766 53014693
Device breakage 11.62 9.67 31 333576 10536 53004923
Atrial flutter 11.62 9.67 101 333506 9490 53005969
Dairy intolerance 11.60 9.67 6 333601 48 53015411
Prevertebral soft tissue swelling of cervical space 11.60 9.67 6 333601 48 53015411
Duodenitis 11.59 9.67 48 333559 3451 53012008
Lipoma 11.58 9.67 36 333571 2246 53013213
Aspartate aminotransferase 11.58 9.67 7 333600 78 53015381
Sinus node dysfunction 11.57 9.67 56 333551 4305 53011154
Mammogram abnormal 11.52 9.67 18 333589 698 53014761
Deformity 11.52 9.67 20 333587 7934 53007525
Ventricular internal diameter abnormal 11.50 9.67 6 333601 49 53015410
International normalised ratio abnormal 11.48 9.67 44 333563 3053 53012406
Hypertensive crisis 11.47 9.67 140 333467 14366 53001093
Dementia Alzheimer's type 11.45 9.67 24 333583 1173 53014286
Acute cutaneous lupus erythematosus 11.44 9.67 11 333596 255 53015204
Pneumocystis jirovecii pneumonia 11.44 9.67 58 333549 16320 52999139
Ageusia 11.43 9.67 125 333482 12489 53002970
Schizophrenia 11.42 9.67 30 333577 10249 53005210
Bundle branch block left 11.35 9.67 79 333528 6934 53008525
Atrial septal defect 11.33 9.67 16 333591 6898 53008561
Lethargy 11.31 9.67 427 333180 53333 52962126
Narrow anterior chamber angle 11.30 9.67 6 333601 51 53015408
Ovarian cyst 11.29 9.67 53 333554 15216 53000243
Speech disorder 11.28 9.67 323 333284 38858 52976601
Parapsoriasis 11.27 9.67 8 333599 119 53015340
Lymphomatoid papulosis 11.27 9.67 8 333599 119 53015340
Fear of injection 11.23 9.67 11 333596 5578 53009881
Ear congestion 11.21 9.67 33 333574 1998 53013461
Gastroduodenal haemorrhage 11.21 9.67 7 333600 83 53015376
Amylase increased 11.21 9.67 70 333537 5924 53009535
Binocular eye movement disorder 11.14 9.67 5 333602 28 53015431
Hypotension 11.12 9.67 1780 331827 252296 52763163
Vascular graft 11.10 9.67 19 333588 796 53014663
Pneumonia 11.10 9.67 2313 331294 404856 52610603
Multiple injuries 11.04 9.67 32 333575 1921 53013538
Vascular device infection 11.03 9.67 7 333600 4414 53011045
Connective tissue inflammation 11.01 9.67 6 333601 54 53015405
Albumin urine present 10.97 9.67 11 333596 269 53015190
Lacunar stroke 10.94 9.67 8 333599 125 53015334
Bifascicular block 10.94 9.67 8 333599 125 53015334
Myeloma cast nephropathy 10.89 9.67 8 333599 126 53015333
Haemorrhagic cyst 10.88 9.67 9 333598 170 53015289
Quadrantanopia 10.86 9.67 5 333602 30 53015429
Pneumonia aspiration 10.85 9.67 150 333457 34151 52981308
Post transplant lymphoproliferative disorder 10.80 9.67 7 333600 4364 53011095
Troponin T increased 10.78 9.67 21 333586 973 53014486
Crohn's disease 10.69 9.67 16 333591 6734 53008725
Hepatocellular carcinoma 10.68 9.67 3 333604 3077 53012382
Musculoskeletal chest pain 10.65 9.67 178 333429 19544 52995915
Bladder neoplasm 10.64 9.67 15 333592 530 53014929
Urine potassium decreased 10.62 9.67 4 333603 13 53015446
Facial paralysis 10.61 9.67 134 333473 13859 53001600
N-terminal prohormone brain natriuretic peptide increased 10.57 9.67 31 333576 1873 53013586
Wrong technique in product usage process 10.56 9.67 290 333317 59742 52955717
Urinary straining 10.47 9.67 5 333602 33 53015426
Sepsis 10.45 9.67 781 332826 145648 52869811
Pulmonary embolism 10.45 9.67 597 333010 113845 52901614
Hypoacusis 10.44 9.67 199 333408 22400 52993059
Scleritis 10.43 9.67 4 333603 3366 53012093
Mandibular mass 10.41 9.67 9 333598 181 53015278
Alpha hydroxybutyrate dehydrogenase increased 10.40 9.67 4 333603 14 53015445
Eyelid retraction 10.39 9.67 6 333601 61 53015398
Basal ganglia haemorrhage 10.38 9.67 16 333591 613 53014846
Colitis microscopic 10.38 9.67 78 333529 7016 53008443
Aortic valve replacement 10.37 9.67 17 333590 687 53014772
Blood potassium increased 10.37 9.67 163 333444 17678 52997781
Cataract operation 10.37 9.67 54 333553 4274 53011185
Therapy partial responder 10.36 9.67 14 333593 6149 53009310
Hyperthermia 10.31 9.67 24 333583 8545 53006914
Alanine aminotransferase 10.31 9.67 6 333601 62 53015397
Diarrhoea 10.28 9.67 4197 329410 621349 52394110
Renal tubular necrosis 10.28 9.67 113 333494 11306 53004153
Lymphadenopathy 10.27 9.67 162 333445 36093 52979366
Feeling abnormal 10.26 9.67 981 332626 134320 52881139
Vitrectomy 10.23 9.67 8 333599 139 53015320
Dilatation atrial 10.22 9.67 33 333574 2101 53013358
Paradoxical drug reaction 10.20 9.67 4 333603 3321 53012138
Gastritis erosive 10.19 9.67 65 333542 5541 53009918
Joint range of motion decreased 10.18 9.67 68 333539 17888 52997571
Fructosamine increased 10.18 9.67 3 333604 3 53015456
Autoimmune encephalopathy 10.18 9.67 3 333604 3 53015456
Body temperature increased 10.18 9.67 144 333463 32655 52982804
Left atrial dilatation 10.17 9.67 31 333576 1914 53013545
Swelling face 10.16 9.67 446 333161 56722 52958737
Hyperprolactinaemia 10.15 9.67 4 333603 3311 53012148
Poverty of speech 10.15 9.67 12 333595 355 53015104
Cystic fibrosis 10.12 9.67 6 333601 3925 53011534
Blood calcium increased 10.12 9.67 87 333520 8149 53007310
Laryngotracheal oedema 10.11 9.67 5 333602 36 53015423
Tenderness 10.08 9.67 77 333530 19653 52995806
Anti-neutrophil cytoplasmic antibody positive vasculitis 10.06 9.67 35 333572 2316 53013143
Malignant polyp 10.05 9.67 9 333598 190 53015269
Abdominal wall haemorrhage 10.04 9.67 8 333599 143 53015316
Muscle rupture 10.03 9.67 34 333573 2220 53013239
Retroperitoneal haematoma 10.01 9.67 40 333567 2830 53012629
Product complaint 10 9.67 119 333488 12138 53003321
Drug dependence 9.96 9.67 86 333521 21386 52994073
Exposure via ingestion 9.85 9.67 4 333603 3251 53012208
Intracranial haematoma 9.83 9.67 12 333595 367 53015092
Arterial disorder 9.78 9.67 22 333585 1129 53014330
Iron deficiency anaemia 9.78 9.67 167 333440 18413 52997046
Atrial tachycardia 9.77 9.67 34 333573 2250 53013209
Accelerated hypertension 9.75 9.67 13 333594 435 53015024
C-reactive protein abnormal 9.74 9.67 109 333498 25761 52989698
Paresis 9.73 9.67 34 333573 2255 53013204
Aortic aneurysm 9.73 9.67 46 333561 3502 53011957
Diabetes mellitus management 9.73 9.67 3 333604 4 53015455
Interventricular septum rupture 9.73 9.67 3 333604 4 53015455
Ocular icterus 9.71 9.67 49 333558 3830 53011629
Erythema 9.71 9.67 847 332760 156122 52859337
End stage renal disease 9.69 9.67 69 333538 6102 53009357
Atrial thrombosis 9.68 9.67 26 333581 1493 53013966

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 1344.61 11.70 2730 331459 78500 32100837
Immune-mediated myositis 1098.45 11.70 469 333720 1206 32178131
Rhabdomyolysis 835.50 11.70 2016 332173 65249 32114088
Blood creatine phosphokinase increased 500.27 11.70 1302 332887 44174 32135163
Drug abuse 449.80 11.70 133 334056 80110 32099227
Toxicity to various agents 425.41 11.70 736 333453 177305 32002032
Myopathy 400.11 11.70 537 333652 10804 32168533
Febrile neutropenia 363.32 11.70 416 333773 119150 32060187
Off label use 362.52 11.70 1769 332420 304551 31874786
Foetal exposure during pregnancy 346.73 11.70 19 334170 41282 32138055
Myocardial infarction 328.33 11.70 2314 331875 123362 32055975
Necrotising myositis 312.01 11.70 138 334051 398 32178939
Coronary artery disease 248.12 11.70 1091 333098 48615 32130722
Drug ineffective 236.01 11.70 2665 331524 380812 31798525
Neutropenia 231.80 11.70 721 333468 141454 32037883
Pyrexia 220.09 11.70 2166 332023 317802 31861535
Drug hypersensitivity 204.74 11.70 1374 332815 72026 32107311
Completed suicide 202.41 11.70 403 333786 92114 32087223
Cerebrovascular accident 187.22 11.70 1522 332667 84798 32094539
Acute myocardial infarction 177.66 11.70 1071 333118 54078 32125259
Angina pectoris 172.42 11.70 710 333479 30716 32148621
Muscular weakness 165.69 11.70 1231 332958 66698 32112639
Death 160.04 11.70 2870 331319 379647 31799690
Blood cholesterol increased 156.27 11.70 469 333720 17288 32162049
Chest pain 149.47 11.70 1940 332249 122197 32057140
Acute kidney injury 146.21 11.70 3998 330191 289470 31889867
Polymyositis 145.37 11.70 122 334067 1384 32177953
Premature baby 142.49 11.70 13 334176 18505 32160832
Dizziness 138.54 11.70 2969 331220 206649 31972688
Low density lipoprotein increased 137.60 11.70 193 333996 4053 32175284
Coronary artery stenosis 120.77 11.70 293 333896 9500 32169837
High density lipoprotein decreased 120.17 11.70 160 334029 3192 32176145
Drug resistance 119.88 11.70 43 334146 22922 32156415
Mucosal inflammation 119.06 11.70 101 334088 33333 32146004
Treatment failure 117.98 11.70 137 334052 39026 32140311
Malignant neoplasm progression 116.82 11.70 414 333775 78082 32101255
Muscle rupture 116.25 11.70 129 334060 2113 32177224
Bone marrow failure 114.33 11.70 87 334102 30317 32149020
Muscle spasms 113.59 11.70 1165 333024 69253 32110084
Pneumonia 108.86 11.70 2801 331388 352451 31826886
Coronary artery occlusion 108.37 11.70 311 333878 11174 32168163
Transient ischaemic attack 107.96 11.70 538 333651 25256 32154081
Cytomegalovirus infection 107.65 11.70 64 334125 25400 32153937
Product use in unapproved indication 104.71 11.70 500 333689 86704 32092633
Angina unstable 103.72 11.70 321 333868 12034 32167303
Acute coronary syndrome 102.37 11.70 346 333843 13595 32165742
White blood cell count decreased 101.46 11.70 537 333652 90661 32088676
Ischaemic stroke 99.48 11.70 401 333788 17175 32162162
Platelet count decreased 98.91 11.70 730 333459 113861 32065476
Pancytopenia 93.98 11.70 551 333638 90684 32088653
Sepsis 90.54 11.70 1121 333068 157713 32021624
Leukopenia 89.49 11.70 317 333872 59805 32119532
Graft versus host disease 87.58 11.70 6 334183 10800 32168537
Neutrophil count decreased 87.03 11.70 225 333964 46914 32132423
Drug interaction 86.45 11.70 2891 331298 215294 31964043
Drug dependence 82.32 11.70 72 334117 23412 32155925
Tendon rupture 81.13 11.70 210 333979 7093 32172244
Suicide attempt 79.00 11.70 172 334017 38072 32141265
Dyspnoea 78.21 11.70 4505 329684 357540 31821797
Myositis 77.40 11.70 273 333916 10962 32168375
Syncope 75.47 11.70 1324 332865 88800 32090537
Stomatitis 75.05 11.70 191 333998 40038 32139299
Overdose 74.02 11.70 557 333632 86520 32092817
Pneumocystis jirovecii pneumonia 73.53 11.70 52 334137 18818 32160519
Thrombocytopenia 73.15 11.70 1078 333111 147221 32032116
Exposure during pregnancy 72.31 11.70 6 334183 9223 32170114
Muscle disorder 71.98 11.70 106 334083 2331 32177006
Autoimmune myositis 71.84 11.70 29 334160 61 32179276
Mitral valve incompetence 71.56 11.70 323 333866 14548 32164789
Low density lipoprotein decreased 69.65 11.70 69 334120 984 32178353
Atrial fibrillation 69.65 11.70 1630 332559 115074 32064263
Amnesia 69.31 11.70 468 333721 24568 32154769
Blood triglycerides increased 69.21 11.70 316 333873 14303 32165034
Vascular stent thrombosis 67.03 11.70 105 334084 2442 32176895
Aspergillus infection 66.99 11.70 18 334171 11556 32167781
Respiratory arrest 66.58 11.70 122 334067 28786 32150551
Ascites 65.94 11.70 203 333986 39988 32139349
Disseminated intravascular coagulation 65.66 11.70 85 334104 23091 32156246
Product use issue 65.45 11.70 299 333890 52478 32126859
Haematuria 65.06 11.70 772 333417 47589 32131748
Bronchopulmonary aspergillosis 64.34 11.70 30 334159 13657 32165680
Plasma cell myeloma 64.18 11.70 339 333850 57275 32122062
Respiratory depression 63.60 11.70 28 334161 13183 32166154
Type 2 diabetes mellitus 63.16 11.70 316 333873 14856 32164481
Infusion related reaction 62.91 11.70 248 333941 45351 32133986
Erectile dysfunction 61.75 11.70 382 333807 19457 32159880
Disease progression 61.49 11.70 583 333606 86279 32093058
Product substitution issue 61.38 11.70 241 333948 10195 32169142
Muscle atrophy 61.32 11.70 187 334002 6953 32172384
Immune reconstitution inflammatory syndrome 61.03 11.70 12 334177 9547 32169790
Product monitoring error 60.77 11.70 101 334088 2473 32176864
Rectal haemorrhage 60.71 11.70 620 333569 36803 32142534
Pain in extremity 58.66 11.70 1619 332570 117282 32062055
Pathogen resistance 58.53 11.70 13 334176 9497 32169840
Myopathy toxic 58.37 11.70 44 334145 422 32178915
Amyotrophic lateral sclerosis 57.96 11.70 63 334126 1007 32178330
Hepatitis C 57.10 11.70 34 334155 13484 32165853
Bradycardia 56.25 11.70 1041 333148 70521 32108816
Septic shock 55.94 11.70 447 333742 68542 32110795
Intentional self-injury 55.90 11.70 37 334152 13863 32165474
Respiratory failure 55.67 11.70 771 333418 106411 32072926
Hypomagnesaemia 55.37 11.70 357 333832 18448 32160889
Melaena 55.13 11.70 572 333617 34093 32145244
Asthenia 54.70 11.70 2956 331233 232988 31946349
Intentional overdose 53.80 11.70 232 333957 41369 32137968
Low birth weight baby 53.57 11.70 5 334184 6989 32172348
Dyspnoea exertional 53.30 11.70 624 333565 38337 32141000
Muscle injury 52.86 11.70 65 334124 1194 32178143
Inferior vena cava dilatation 52.57 11.70 50 334139 676 32178661
Infection 52.40 11.70 587 333602 84128 32095209
Rheumatoid arthritis 51.92 11.70 258 333931 44286 32135051
Upper gastrointestinal haemorrhage 51.87 11.70 421 333768 23428 32155909
Chromaturia 50.34 11.70 287 333902 14191 32165146
Poisoning 50.11 11.70 26 334163 11132 32168205
Labelled drug-drug interaction medication error 49.89 11.70 256 333933 12157 32167180
Myocardial ischaemia 49.77 11.70 333 333856 17426 32161911
Intentional product misuse 49.77 11.70 196 333993 35855 32143482
Muscle necrosis 49.65 11.70 52 334137 795 32178542
Posterior reversible encephalopathy syndrome 48.18 11.70 19 334170 9557 32169780
Multiple organ dysfunction syndrome 48.09 11.70 472 333717 69382 32109955
Cytokine release syndrome 48.04 11.70 41 334148 13494 32165843
Fall 47.42 11.70 2468 331721 193733 31985604
Blood glucose increased 47.15 11.70 937 333252 64304 32115033
Myelosuppression 47.06 11.70 31 334158 11645 32167692
Presyncope 46.45 11.70 321 333868 16980 32162357
Serotonin syndrome 46.45 11.70 78 334111 19039 32160298
Myocardial necrosis marker increased 45.98 11.70 69 334120 1544 32177793
Acute myeloid leukaemia 45.88 11.70 79 334110 19095 32160242
Haemophagocytic lymphohistiocytosis 45.82 11.70 30 334159 11305 32168032
Hypertensive emergency 45.64 11.70 51 334138 842 32178495
Lactic acidosis 45.38 11.70 536 333653 33000 32146337
Restlessness 44.97 11.70 120 334069 24761 32154576
Ejection fraction decreased 44.13 11.70 322 333867 17336 32162001
Seizure 43.81 11.70 777 333412 103077 32076260
Cardiac failure 43.71 11.70 1243 332946 90430 32088907
Glycosylated haemoglobin increased 43.68 11.70 217 333972 10172 32169165
Therapeutic product effect incomplete 43.43 11.70 248 333941 41093 32138244
Product prescribing error 43.39 11.70 349 333840 19368 32159969
Hepatocellular carcinoma 43.14 11.70 26 334163 10244 32169093
Neurotoxicity 42.96 11.70 55 334134 15015 32164322
Ventricular hypokinesia 42.70 11.70 129 334060 4771 32174566
Liver function test abnormal 42.08 11.70 508 333681 31439 32147898
Diabetic ketoacidosis 41.99 11.70 322 333867 17610 32161727
Oedema peripheral 41.61 11.70 1498 332691 112593 32066744
Muscle enzyme increased 41.55 11.70 28 334161 221 32179116
Cardiac disorder 41.30 11.70 632 333557 41234 32138103
Intentional product use issue 41.29 11.70 259 333930 41952 32137385
Epstein-Barr virus infection 41.08 11.70 11 334178 7079 32172258
Hepatic encephalopathy 40.79 11.70 56 334133 14839 32164498
Ischaemic cardiomyopathy 40.64 11.70 152 334037 6282 32173055
C-reactive protein abnormal 40.54 11.70 8 334181 6348 32172989
Faeces discoloured 40.52 11.70 277 333912 14600 32164737
Low density lipoprotein abnormal 40.51 11.70 29 334160 255 32179082
Progressive multifocal leukoencephalopathy 40.22 11.70 24 334165 9507 32169830
Coma 39.88 11.70 265 333924 42347 32136990
Tumour lysis syndrome 39.53 11.70 55 334134 14492 32164845
Dermatomyositis 38.96 11.70 55 334134 1162 32178175
Peritonitis 38.63 11.70 110 334079 22220 32157117
Hypoglycaemia 37.95 11.70 777 333412 53605 32125732
Post transplant lymphoproliferative disorder 37.93 11.70 7 334182 5827 32173510
Hyperkalaemia 37.89 11.70 962 333227 68788 32110549
Arteriosclerosis 37.88 11.70 218 333971 10816 32168521
Blood cholesterol decreased 37.27 11.70 49 334140 965 32178372
Agitation 37.22 11.70 392 333797 56844 32122493
Glomerular filtration rate decreased 36.97 11.70 242 333947 12569 32166768
Atrial septal defect 36.92 11.70 13 334176 7012 32172325
Cardiac failure congestive 36.77 11.70 1137 333052 83715 32095622
Carotid artery stenosis 36.52 11.70 122 334067 4764 32174573
Exercise lack of 36.34 11.70 20 334169 104 32179233
Cardiac failure chronic 36.15 11.70 159 334030 7081 32172256
Bacteraemia 35.83 11.70 80 334109 17553 32161784
Cystitis haemorrhagic 35.80 11.70 5 334184 5109 32174228
Stent placement 35.77 11.70 116 334073 4459 32174878
Pancreatitis acute 35.71 11.70 434 333755 26901 32152436
Coronary artery bypass 35.53 11.70 124 334065 4952 32174385
Hepatitis cholestatic 35.43 11.70 173 334016 8052 32171285
Heart rate irregular 35.34 11.70 257 333932 13821 32165516
Tendonitis 34.30 11.70 179 334010 8556 32170781
Cardio-respiratory arrest 34.19 11.70 389 333800 55600 32123737
Hepatocellular injury 33.96 11.70 404 333785 24914 32154423
International normalised ratio increased 33.68 11.70 699 333490 48336 32131001
Muscle fatigue 33.42 11.70 52 334137 1202 32178135
Vascular stent stenosis 33.32 11.70 48 334141 1034 32178303
Drug withdrawal syndrome 33.31 11.70 102 334087 20129 32159208
Neoplasm progression 33.16 11.70 98 334091 19560 32159777
Myelodysplastic syndrome 33.01 11.70 101 334088 19937 32159400
Maternal drugs affecting foetus 32.91 11.70 3 334186 4274 32175063
Balance disorder 32.03 11.70 577 333612 38882 32140455
Neuroleptic malignant syndrome 31.90 11.70 84 334105 17411 32161926
Haematochezia 31.71 11.70 573 333616 38635 32140702
Neonatal respiratory distress syndrome 31.67 11.70 3 334186 4144 32175193
Abnormal behaviour 31.58 11.70 152 334037 26314 32153023
Diabetes mellitus inadequate control 31.55 11.70 246 333943 13522 32165815
Haematoma 31.50 11.70 403 333786 25281 32154056
Diabetic nephropathy 31.47 11.70 69 334120 2090 32177247
Orthostatic hypotension 31.26 11.70 402 333787 25248 32154089
Akathisia 30.62 11.70 17 334172 7008 32172329
Polymyalgia rheumatica 30.59 11.70 51 334138 1252 32178085
Vomiting 30.57 11.70 2048 332141 233509 31945828
Febrile bone marrow aplasia 30.47 11.70 25 334164 8390 32170947
Arteriosclerosis coronary artery 30.46 11.70 218 333971 11663 32167674
Hyperlipidaemia 30.39 11.70 254 333935 14257 32165080
Hypercholesterolaemia 30.35 11.70 162 334027 7812 32171525
Tricuspid valve incompetence 30.28 11.70 181 334008 9106 32170231
Substance abuse 29.84 11.70 18 334171 7089 32172248
Blood creatine phosphokinase MB increased 29.75 11.70 64 334125 1913 32177424
Cytomegalovirus viraemia 29.73 11.70 16 334173 6711 32172626
Gastrointestinal haemorrhage 29.54 11.70 1132 333057 85750 32093587
Exercise tolerance decreased 29.49 11.70 109 334080 4479 32174858
Troponin increased 29.42 11.70 189 334000 9753 32169584
Intermittent claudication 29.39 11.70 70 334119 2242 32177095
Blood cholesterol 29.16 11.70 20 334169 163 32179174
Blood cholesterol abnormal 29.16 11.70 54 334135 1444 32177893
Lymphocyte count decreased 29.03 11.70 115 334074 21004 32158333
Coronary artery restenosis 28.77 11.70 47 334142 1134 32178203
Myoglobin blood increased 28.74 11.70 61 334128 1806 32177531
Swollen tongue 28.70 11.70 239 333950 13400 32165937
Enterococcal infection 28.63 11.70 31 334158 9116 32170221
Depressed level of consciousness 28.52 11.70 275 333914 40572 32138765
Palpitations 28.50 11.70 524 333665 35445 32143892
Blood loss anaemia 28.45 11.70 159 334030 7803 32171534
Aggression 28.44 11.70 263 333926 39126 32140211
Cerebral haemorrhage 28.17 11.70 508 333681 34239 32145098
Glycogen storage disease type V 27.79 11.70 12 334177 32 32179305
Genital swelling 27.74 11.70 20 334169 178 32179159
Nocturia 27.70 11.70 177 334012 9117 32170220
Type IIa hyperlipidaemia 27.48 11.70 21 334168 206 32179131
Acute respiratory distress syndrome 27.33 11.70 150 334039 25103 32154234
Haematotoxicity 27.30 11.70 18 334171 6758 32172579
Hypoalbuminaemia 27.12 11.70 50 334139 11772 32167565
Psychotic disorder 27.01 11.70 133 334056 22887 32156450
Condition aggravated 26.96 11.70 1316 332873 154345 32024992
Stenosis 26.93 11.70 43 334146 1017 32178320
Maternal exposure during pregnancy 26.73 11.70 6 334183 4351 32174986
Drug use disorder 26.67 11.70 3 334186 3618 32175719
Status epilepticus 26.47 11.70 52 334137 11954 32167383
Pseudomonas infection 25.91 11.70 53 334136 12003 32167334
Ocular myasthenia 25.83 11.70 21 334168 227 32179110
Haemorrhagic stroke 25.61 11.70 133 334056 6345 32172992
Carotid artery occlusion 25.37 11.70 63 334126 2073 32177264
Pruritus genital 25.27 11.70 31 334158 568 32178769
Hepatitis B reactivation 25.04 11.70 3 334186 3446 32175891
Musculoskeletal pain 25.04 11.70 464 333725 31433 32147904
Blood urea abnormal 24.80 11.70 36 334153 781 32178556
Toxic epidermal necrolysis 24.73 11.70 118 334071 20475 32158862
Candida infection 24.72 11.70 89 334100 16714 32162623
Ileus 24.69 11.70 85 334104 16180 32163157
Ventricular enlargement 24.53 11.70 27 334162 438 32178899
Cytopenia 24.51 11.70 41 334148 10023 32169314
Hepatic enzyme increased 24.47 11.70 525 333664 36512 32142825
Drug ineffective for unapproved indication 24.46 11.70 68 334121 13844 32165493
Lipids abnormal 24.35 11.70 24 334165 340 32178997
Quadriparesis 24.33 11.70 45 334144 1202 32178135
N-terminal prohormone brain natriuretic peptide increased 24.21 11.70 60 334129 1972 32177365
Encephalopathy 24.18 11.70 230 333959 34027 32145310
Hyperammonaemia 23.85 11.70 16 334173 5953 32173384
Hypotension 23.51 11.70 2551 331638 213559 31965778
Acquired claw toe 23.24 11.70 8 334181 8 32179329
Transplant rejection 23.20 11.70 42 334147 9957 32169380
Device related infection 23.18 11.70 100 334089 17833 32161504
Computerised tomogram coronary artery abnormal 23.07 11.70 17 334172 157 32179180
Respiratory distress 23.06 11.70 241 333948 35005 32144332
Pericardial haemorrhage 23.01 11.70 77 334112 3009 32176328
Electrocardiogram ST segment depression 22.93 11.70 66 334123 2375 32176962
Therapy partial responder 22.87 11.70 11 334178 4919 32174418
Haemorrhage intracranial 22.86 11.70 257 333932 15630 32163707
Hyperbilirubinaemia 22.84 11.70 99 334090 17631 32161706
Muscle discomfort 22.80 11.70 11 334178 41 32179296
Muscle strain 22.78 11.70 89 334100 3756 32175581
Lip swelling 22.77 11.70 229 333960 13536 32165801
Essential hypertension 22.64 11.70 70 334119 2622 32176715
Tachycardia 22.63 11.70 629 333560 78459 32100878
Osteonecrosis 22.54 11.70 91 334098 16531 32162806
Pneumatosis intestinalis 22.46 11.70 4 334185 3416 32175921
Cardiac aneurysm 22.20 11.70 37 334152 908 32178429
Shock 22.04 11.70 151 334038 23963 32155374
Pelvic mass 22.04 11.70 18 334171 196 32179141
Eye injury 21.96 11.70 31 334158 655 32178682
Epilepsy 21.96 11.70 135 334054 21974 32157363
Potassium wasting nephropathy 21.90 11.70 14 334175 100 32179237
Degenerative mitral valve disease 21.78 11.70 19 334170 228 32179109
Abnormal weight gain 21.77 11.70 37 334152 923 32178414
Osteonecrosis of jaw 21.76 11.70 112 334077 19054 32160283
Dystonia 21.74 11.70 48 334141 10575 32168762
Carotid artery disease 21.66 11.70 37 334152 927 32178410
Mixed liver injury 21.62 11.70 67 334122 2513 32176824
Abdominal pain 21.62 11.70 1287 332902 148242 32031095
Thrombocytopenic purpura 21.60 11.70 42 334147 1166 32178171
Sinusitis 21.54 11.70 256 333933 36304 32143033
Ventricular septal defect 21.45 11.70 6 334183 3751 32175586
Arterial stenosis 21.44 11.70 43 334146 1222 32178115
Nocardiosis 21.22 11.70 6 334183 3725 32175612
Oropharyngeal pain 21.08 11.70 213 333976 31139 32148198
Atrial enlargement 21.00 11.70 21 334168 303 32179034
Palmar-plantar erythrodysaesthesia syndrome 20.86 11.70 87 334102 15662 32163675
Clostridium difficile infection 20.77 11.70 103 334086 17693 32161644
Asthma 20.75 11.70 323 333866 43742 32135595
Vertigo 20.74 11.70 358 333831 23925 32155412
Product odour abnormal 20.68 11.70 31 334158 693 32178644
Pneumonia aspiration 20.65 11.70 298 333891 40858 32138479
Pneumonia cytomegaloviral 20.59 11.70 3 334186 2969 32176368
Oxygen saturation decreased 20.54 11.70 359 333830 47740 32131597
Penile haemorrhage 20.50 11.70 29 334160 614 32178723
Dyskinesia 20.50 11.70 150 334039 23453 32155884
Plantar fasciitis 20.43 11.70 37 334152 972 32178365
Radiculitis brachial 20.41 11.70 8 334181 15 32179322
Apparent death 20.22 11.70 6 334183 3609 32175728
Cardiac failure acute 20.14 11.70 176 334013 10008 32169329
Normocytic anaemia 20.12 11.70 58 334131 2089 32177248
Dyspnoea at rest 20.10 11.70 78 334111 3281 32176056
Mycobacterium avium complex infection 20.08 11.70 3 334186 2914 32176423
Cerebral infarction 20.07 11.70 397 333792 27217 32152120
Shock haemorrhagic 20.04 11.70 182 334007 10463 32168874
Peripheral vascular disorder 19.99 11.70 107 334082 5165 32174172
Colitis 19.90 11.70 238 333951 33713 32145624
Cerebral haematoma 19.88 11.70 100 334089 4711 32174626
Lipids increased 19.79 11.70 36 334153 949 32178388
Fungal infection 19.76 11.70 85 334104 15170 32164167
Brain oedema 19.49 11.70 68 334121 12892 32166445
Altered state of consciousness 19.49 11.70 139 334050 21858 32157479
Hepatojugular reflux 19.47 11.70 22 334167 368 32178969
Transient global amnesia 19.35 11.70 21 334168 335 32179002
Obstructive pancreatitis 19.26 11.70 24 334165 447 32178890
Diffuse large B-cell lymphoma 19.22 11.70 36 334153 8426 32170911
Myasthenia gravis 19.20 11.70 81 334108 3541 32175796
Vitreous detachment 19.20 11.70 33 334156 831 32178506
Lymphadenopathy 19.04 11.70 182 334007 26900 32152437
Acquired haemophilia 18.97 11.70 34 334155 886 32178451
Cytomegalovirus test positive 18.88 11.70 8 334181 3854 32175483
Cardiotoxicity 18.68 11.70 14 334175 4918 32174419
Hypocalcaemia 18.66 11.70 337 333852 22717 32156620
Penis injury 18.66 11.70 18 334171 248 32179089
Somnolence 18.65 11.70 874 333315 102923 32076414
Appendicitis 18.61 11.70 40 334149 8897 32170440
Lymph node calcification 18.59 11.70 17 334172 218 32179119
Oscillopsia 18.57 11.70 9 334180 34 32179303
Atrial flutter 18.51 11.70 238 333951 14945 32164392
Venoocclusive disease 18.50 11.70 3 334186 2743 32176594
Memory impairment 18.48 11.70 546 333643 39933 32139404
Thrombotic microangiopathy 18.47 11.70 44 334145 9438 32169899
Hepatic failure 18.37 11.70 257 333932 35423 32143914
Non-cardiac chest pain 18.35 11.70 91 334098 4262 32175075
Aortic aneurysm 18.23 11.70 125 334064 6594 32172743
Disease recurrence 18.17 11.70 94 334095 15970 32163367
Peripheral ischaemia 18.15 11.70 112 334077 5699 32173638
Enthesopathy 18.04 11.70 7 334182 3556 32175781
Staphylococcal infection 18.03 11.70 230 333959 32209 32147128
Pulmonary vascular disorder 18.03 11.70 27 334162 603 32178734
Peripheral paralysis 17.99 11.70 9 334180 37 32179300
Arterial occlusive disease 17.96 11.70 90 334099 4233 32175104
Pneumonia fungal 17.82 11.70 23 334166 6257 32173080
Hepatitis acute 17.82 11.70 133 334056 7212 32172125
Diabetes mellitus 17.65 11.70 598 333591 44575 32134762
Fibrous histiocytoma 17.65 11.70 13 334176 120 32179217
Hypercalcaemia 17.64 11.70 78 334111 13816 32165521
On and off phenomenon 17.53 11.70 7 334182 3494 32175843
Pulmonary valve incompetence 17.47 11.70 30 334159 755 32178582
Sedation 17.43 11.70 115 334074 18411 32160926
Occupational problem environmental 17.43 11.70 6 334183 6 32179331
Avoidant personality disorder 17.43 11.70 6 334183 6 32179331
Klebsiella infection 17.41 11.70 35 334154 7977 32171360
Herbal interaction 17.40 11.70 20 334169 341 32178996
Accidental exposure to product 17.37 11.70 58 334131 11144 32168193
Ageusia 17.32 11.70 164 334025 9538 32169799
Miosis 17.27 11.70 40 334149 8664 32170673
Cardiac valve disease 17.25 11.70 71 334118 3069 32176268
Blood triglycerides decreased 17.17 11.70 10 334179 59 32179278
Foetal growth restriction 17.07 11.70 10 334179 4002 32175335
Paraesthesia 17.05 11.70 755 333434 58189 32121148
Neutropenic colitis 17.03 11.70 3 334186 2582 32176755
Drug abuser 17.01 11.70 11 334178 4173 32175164
Left atrial dilatation 16.99 11.70 50 334139 1822 32177515
Product administered to patient of inappropriate age 16.94 11.70 4 334185 2802 32176535
Systemic candida 16.92 11.70 5 334184 3016 32176321
Crohn's disease 16.89 11.70 12 334177 4333 32175004
Blood immunoglobulin E increased 16.85 11.70 53 334136 2004 32177333
Nicotine dependence 16.76 11.70 24 334165 514 32178823
Pulmonary haemorrhage 16.73 11.70 49 334140 9808 32169529
Gynaecomastia 16.71 11.70 151 334038 8668 32170669
Withdrawal syndrome 16.66 11.70 66 334123 12056 32167281
Nephropathy toxic 16.45 11.70 65 334124 11881 32167456
Gout 16.32 11.70 277 333912 18451 32160886
Pruritus 16.24 11.70 1535 332654 127167 32052170
Impatience 16.21 11.70 18 334171 295 32179042
Generalised tonic-clonic seizure 16.13 11.70 135 334054 20504 32158833
Benign pancreatic neoplasm 16.12 11.70 6 334183 9 32179328
Angiocardiogram 16.12 11.70 15 334174 197 32179140
Type V hyperlipidaemia 16.04 11.70 28 334161 714 32178623
Lipoprotein (a) increased 16.03 11.70 9 334180 49 32179288
Psychomotor hyperactivity 16.03 11.70 44 334145 8995 32170342
Hypertransaminasaemia 16.02 11.70 85 334104 4089 32175248
Autoimmune disorder 15.92 11.70 45 334144 1602 32177735
Lipodystrophy acquired 15.92 11.70 9 334180 3673 32175664
Aortic stenosis 15.86 11.70 86 334103 4172 32175165
Paradoxical drug reaction 15.85 11.70 5 334184 2891 32176446
Tuberculosis 15.85 11.70 42 334147 8687 32170650
Bacterial infection 15.82 11.70 82 334107 13924 32165413
Vascular graft 15.81 11.70 42 334147 1441 32177896
Chest discomfort 15.79 11.70 649 333540 49581 32129756
Autoimmune myocarditis 15.72 11.70 14 334175 173 32179164
Subarachnoid haemorrhage 15.71 11.70 170 334019 10241 32169096
Suicidal ideation 15.70 11.70 286 333903 37797 32141540
Delirium 15.68 11.70 339 333850 43707 32135630
Spinal stenosis 15.65 11.70 90 334099 4464 32174873
Anticoagulation drug level increased 15.61 11.70 23 334166 506 32178831
Staphylococcal sepsis 15.60 11.70 51 334138 9862 32169475
Bilirubin conjugated abnormal 15.60 11.70 12 334177 119 32179218
Aortic valve replacement 15.48 11.70 28 334161 735 32178602
Iliac artery stenosis 15.43 11.70 11 334178 96 32179241
Liver transplant 15.37 11.70 5 334184 2835 32176502
Diffuse large B-cell lymphoma recurrent 15.32 11.70 4 334185 2618 32176719
Adrenal insufficiency 15.31 11.70 67 334122 11901 32167436
Hepatitis B 15.28 11.70 26 334163 6315 32173022
Clonus 15.25 11.70 4 334185 2610 32176727
C-reactive protein increased 15.22 11.70 377 333812 47725 32131612
Epicondylitis 15.18 11.70 21 334168 435 32178902
Hepatic vein dilatation 15.08 11.70 15 334174 215 32179122
Post micturition dribble 15.06 11.70 6 334183 12 32179325
Cystic fibrosis 15.04 11.70 3 334186 2363 32176974
Mydriasis 15.02 11.70 27 334162 6419 32172918
Cytomegalovirus infection reactivation 14.99 11.70 8 334181 3371 32175966
Ventricular dyskinesia 14.97 11.70 14 334175 185 32179152
Drug level increased 14.96 11.70 133 334056 19947 32159390
Rhinovirus infection 14.94 11.70 8 334181 3365 32175972
Mastitis 14.86 11.70 14 334175 187 32179150
Portal hypertension 14.81 11.70 12 334177 4052 32175285
Bundle branch block left 14.79 11.70 106 334083 5673 32173664
Violence-related symptom 14.71 11.70 23 334166 534 32178803
Cholestasis 14.71 11.70 373 333816 26660 32152677
Acute lymphocytic leukaemia 14.64 11.70 9 334180 3509 32175828
Gastrointestinal angiodysplasia 14.59 11.70 25 334164 628 32178709
Deep vein thrombosis 14.52 11.70 522 333667 63191 32116146
Second primary malignancy 14.51 11.70 31 334158 6910 32172427
Blood creatine phosphokinase abnormal 14.49 11.70 15 334174 226 32179111
Pollakiuria 14.48 11.70 272 333917 18472 32160865
Aldolase increased 14.46 11.70 9 334180 61 32179276
Aortic arteriosclerosis 14.43 11.70 81 334108 3981 32175356
Blood glucose decreased 14.39 11.70 207 333982 13327 32166010
Hepatitis A virus test positive 14.35 11.70 4 334185 0 32179337
Immunology test abnormal 14.35 11.70 4 334185 0 32179337
Arterial repair 14.35 11.70 4 334185 0 32179337
Cells in urine 14.35 11.70 4 334185 0 32179337
Sopor 14.30 11.70 67 334122 11682 32167655
Scrotal pain 14.30 11.70 30 334159 881 32178456
Hypogammaglobulinaemia 14.27 11.70 26 334163 6150 32173187
Herpes zoster 14.25 11.70 240 333949 32101 32147236
Eructation 14.25 11.70 80 334109 3933 32175404
Helicobacter test positive 14.22 11.70 27 334162 736 32178601
Therapy non-responder 14.17 11.70 243 333946 32411 32146926
AST/ALT ratio abnormal 14.17 11.70 6 334183 15 32179322
Skin toxicity 14.17 11.70 11 334178 3795 32175542
Electrocardiogram ST-T change 14.14 11.70 24 334165 598 32178739
Brain natriuretic peptide increased 14.14 11.70 84 334105 4216 32175121
Congenital diaphragmatic anomaly 14.14 11.70 7 334182 28 32179309
Blood creatine increased 14.10 11.70 92 334097 4773 32174564
Metastases to central nervous system 14.06 11.70 37 334152 7671 32171666
Therapeutic product effect decreased 14.05 11.70 229 333960 30788 32148549
Toe amputation 14.05 11.70 55 334134 2323 32177014
Hepatic cirrhosis 14.04 11.70 108 334081 16701 32162636
Atrioventricular block second degree 13.96 11.70 71 334118 3359 32175978
Hemianaesthesia 13.96 11.70 10 334179 88 32179249
Lacunar stroke 13.96 11.70 12 334177 141 32179196
Therapeutic response decreased 13.96 11.70 185 334004 25735 32153602
ECG signs of myocardial ischaemia 13.95 11.70 14 334175 203 32179134
Haematoma muscle 13.94 11.70 32 334157 1000 32178337
Ventricular hypertrophy 13.91 11.70 93 334096 4865 32174472
Wound haematoma 13.89 11.70 9 334180 66 32179271
Liver palpable 13.82 11.70 16 334173 275 32179062
Microcytic anaemia 13.80 11.70 52 334137 2157 32177180
Blood pressure inadequately controlled 13.76 11.70 60 334129 2662 32176675
Right ventricular enlargement 13.73 11.70 14 334175 207 32179130
Nipple pain 13.70 11.70 24 334165 614 32178723
Drug screen positive 13.69 11.70 14 334175 4227 32175110
Primary biliary cholangitis 13.69 11.70 12 334177 145 32179192
Systolic dysfunction 13.69 11.70 53 334136 2227 32177110
Peripheral artery occlusion 13.67 11.70 42 334147 1568 32177769
Weight decreased 13.65 11.70 1913 332276 162905 32016432
Herpes simplex 13.62 11.70 20 334169 5154 32174183
Dilatation atrial 13.60 11.70 51 334138 2110 32177227
Angioedema 13.58 11.70 478 333711 35811 32143526
Clostridium difficile colitis 13.46 11.70 89 334100 14242 32165095
Cardiac stress test abnormal 13.45 11.70 18 334171 361 32178976
Neutropenic sepsis 13.43 11.70 76 334113 12623 32166714
Sinus bradycardia 13.41 11.70 197 333992 12741 32166596
Gamma-glutamyltransferase abnormal 13.41 11.70 15 334174 248 32179089
Anal abscess 13.40 11.70 23 334166 5567 32173770
Conjunctival hyperaemia 13.38 11.70 4 334185 2394 32176943
Chronic kidney disease 13.37 11.70 520 333669 39455 32139882
Neuromyopathy 13.34 11.70 31 334158 977 32178360
Peripheral coldness 13.32 11.70 118 334071 6735 32172602
Dyspnoea paroxysmal nocturnal 13.28 11.70 40 334149 1477 32177860
Cardiac ablation 13.27 11.70 24 334165 630 32178707
Synovitis 13.25 11.70 62 334127 10816 32168521
Device issue 13.24 11.70 47 334142 8865 32170472
Hypernatraemia 13.20 11.70 42 334147 8191 32171146
Central obesity 13.20 11.70 22 334167 540 32178797
Urticaria chronic 13.18 11.70 10 334179 97 32179240
Peripheral artery stenosis 13.13 11.70 29 334160 883 32178454
Product contamination physical 13.09 11.70 7 334182 34 32179303
Discoloured vomit 13.08 11.70 21 334168 499 32178838
Alcohol abuse 13.08 11.70 16 334173 4456 32174881
Peripheral arterial occlusive disease 13.08 11.70 102 334087 5607 32173730
Hypoxia 13.07 11.70 422 333767 51710 32127627
Ammonia increased 13.03 11.70 16 334173 4448 32174889
Lacunar infarction 13.00 11.70 66 334123 3120 32176217
Euphoric mood 13 11.70 21 334168 5206 32174131
Spur cell anaemia 13.00 11.70 8 334181 53 32179284
Carcinoid tumour of the gastrointestinal tract 13.00 11.70 8 334181 53 32179284
Tendon pain 13.00 11.70 60 334129 2728 32176609
Inclusion body myositis 12.94 11.70 6 334183 20 32179317
Pneumothorax 12.81 11.70 117 334072 17453 32161884
Periodontitis 12.79 11.70 46 334143 1865 32177472
Infective exacerbation of chronic obstructive airways disease 12.77 11.70 45 334144 1806 32177531
Gastric ulcer haemorrhage 12.74 11.70 100 334089 5507 32173830
Autoimmune hepatitis 12.66 11.70 77 334112 3898 32175439
Escherichia infection 12.58 11.70 35 334154 7125 32172212
Splenomegaly 12.57 11.70 92 334097 14385 32164952
Cutaneous lupus erythematosus 12.57 11.70 25 334164 706 32178631
Peritonitis bacterial 12.57 11.70 76 334113 12420 32166917
Atrioventricular block complete 12.56 11.70 144 334045 8800 32170537
Muscle contractions involuntary 12.56 11.70 46 334143 1882 32177455
Gait inability 12.55 11.70 282 333907 19765 32159572
Implantable defibrillator insertion 12.54 11.70 25 334164 707 32178630
Blood electrolytes abnormal 12.51 11.70 30 334159 965 32178372
Intraventricular haemorrhage 12.47 11.70 65 334124 3105 32176232
Pulmonary tuberculosis 12.45 11.70 20 334169 4969 32174368
Occult blood positive 12.44 11.70 78 334111 3991 32175346
Small intestinal obstruction 12.43 11.70 90 334099 14106 32165231
Catheter site haematoma 12.40 11.70 12 334177 166 32179171
Laryngeal haematoma 12.35 11.70 11 334178 136 32179201
Nausea 12.34 11.70 3018 331171 317831 31861506
Benign prostatic hyperplasia 12.32 11.70 187 334002 12177 32167160
Sinonasal obstruction 12.31 11.70 6 334183 23 32179314
Spermatozoa abnormal 12.31 11.70 8 334181 59 32179278
Streptococcal infection 12.28 11.70 20 334169 4942 32174395
Abnormal loss of weight 12.26 11.70 77 334112 3942 32175395
Aplastic anaemia 12.26 11.70 37 334152 7336 32172001
Thrombosis in device 12.25 11.70 70 334119 3464 32175873
Lipid metabolism disorder 12.22 11.70 15 334174 275 32179062
Hyponatraemic syndrome 12.21 11.70 14 334175 238 32179099
Decreased gait velocity 12.16 11.70 11 334178 139 32179198
Adenocarcinoma gastric 12.14 11.70 34 334155 1204 32178133
Vascular graft occlusion 12.14 11.70 23 334166 626 32178711
Brain stem haematoma 12.09 11.70 11 334178 140 32179197
Haemorrhagic transformation stroke 12.07 11.70 36 334153 1322 32178015
Oesophageal pain 12.07 11.70 26 334163 778 32178559
Idiopathic pulmonary fibrosis 12.06 11.70 82 334107 4313 32175024
Delusion 12.02 11.70 82 334107 13026 32166311
Mitochondrial toxicity 12.00 11.70 6 334183 2624 32176713
Heart valve incompetence 11.97 11.70 35 334154 1271 32178066
Subdural haematoma 11.97 11.70 279 333910 19674 32159663
Lower gastrointestinal haemorrhage 11.96 11.70 141 334048 8676 32170661
Urine flow decreased 11.95 11.70 34 334155 1215 32178122
Coronary artery surgery 11.95 11.70 10 334179 113 32179224
Accidental overdose 11.94 11.70 134 334055 19205 32160132
Mean cell volume abnormal 11.89 11.70 15 334174 283 32179054
Paratracheal lymphadenopathy 11.88 11.70 9 334180 87 32179250
Pseudohyponatraemia 11.88 11.70 9 334180 87 32179250
Nonalcoholic fatty liver disease 11.87 11.70 16 334173 323 32179014
Loss of personal independence in daily activities 11.86 11.70 199 333990 26634 32152703
Liver transplant rejection 11.85 11.70 4 334185 2215 32177122
Dysmorphism 11.83 11.70 7 334182 2786 32176551
Mouth swelling 11.80 11.70 42 334147 1694 32177643
Blood alkaline phosphatase abnormal 11.79 11.70 19 334170 453 32178884
Skin discomfort 11.78 11.70 8 334181 64 32179273
BK virus infection 11.78 11.70 20 334169 4861 32174476
Cold sweat 11.75 11.70 155 334034 9791 32169546
Pleural effusion 11.73 11.70 678 333511 78314 32101023
Blood glucose fluctuation 11.73 11.70 76 334113 3933 32175404
Intestinal obstruction 11.73 11.70 147 334042 20651 32158686
Flatulence 11.72 11.70 271 333918 19084 32160253
Inflammation 11.71 11.70 179 334010 24314 32155023

Pharmacologic Action:

SourceCodeDescription
ATC C10AA05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
HMG CoA reductase inhibitors
ATC C10BA05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BX03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX11 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX12 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX15 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX18 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA MoA N0000000121 Hydroxymethylglutaryl-CoA Reductase Inhibitors
FDA EPC N0000175589 HMG-CoA Reductase Inhibitor
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D000924 Anticholesteremic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D019161 Hydroxymethylglutaryl-CoA Reductase Inhibitors
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Arteriosclerotic vascular disease indication 72092001
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Cerebrovascular accident indication 230690007
Familial hypercholesterolemia - homozygous indication 238078005
Familial hypercholesterolemia - heterozygous indication 238079002
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006
Familial type 3 hyperlipoproteinemia indication 398796005 DOID:3145
Slow Progression of Coronary Artery Disease indication
Primary Prevention of Coronary Heart Disease indication
Myocardial Infarction Prevention indication
Prevention of Transient Ischemic Attacks off-label use
Alcoholism contraindication 7200002
Hypothyroidism contraindication 40930008 DOID:1459
Low blood pressure contraindication 45007003
Hepatic failure contraindication 59927004
Chronic idiopathic constipation contraindication 82934008
Kidney disease contraindication 90708001 DOID:557
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hemorrhagic cerebral infarction contraindication 230706003
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Pregnancy, function contraindication 289908002
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Traumatic injury contraindication 417746004
Severe Aortic Valve Stenosis contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.44 acidic
pKa2 11.82 acidic
pKa3 13.63 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme INHIBITOR IC50 8 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme IC50 5.29 CHEMBL
Histone deacetylase 2 Enzyme IC50 4.65 CHEMBL
Histone deacetylase 1 Enzyme IC50 4.93 CHEMBL
Histone deacetylase 6 Enzyme IC50 4.84 CHEMBL
Nuclear receptor subfamily 1 group I member 3 Nuclear hormone receptor WOMBAT-PK
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 8.42 CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 4.49 CHEMBL

External reference:

IDSource
4024041 VUID
N0000022046 NUI
D00887 KEGG_DRUG
134523-03-8 SECONDARY_CAS_RN
1297766 RXNORM
C0286651 UMLSCUI
CHEBI:39548 CHEBI
117 PDB_CHEM_ID
CHEMBL1487 ChEMBL_ID
CHEMBL393220 ChEMBL_ID
CHEMBL1790017 ChEMBL_ID
D000069059 MESH_DESCRIPTOR_UI
DB01076 DRUGBANK_ID
2949 IUPHAR_LIGAND_ID
7259 INN_ID
A0JWA85V8F UNII
60823 PUBCHEM_CID
186242 MMSL
34584 MMSL
4226 MMSL
d04105 MMSL
006321 NDDF
006322 NDDF
108600003 SNOMEDCT_US
108601004 SNOMEDCT_US
373444002 SNOMEDCT_US
725658002 SNOMEDCT_US
4020999 VANDF
4024041 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2270 TABLET, FILM COATED 80 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2960 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2970 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2980 TABLET, FILM COATED 40 mg ORAL NDA 32 sections
Lipitor HUMAN PRESCRIPTION DRUG LABEL 1 0071-0155 TABLET, FILM COATED 10 mg ORAL NDA 29 sections
Lipitor HUMAN PRESCRIPTION DRUG LABEL 1 0071-0156 TABLET, FILM COATED 20 mg ORAL NDA 29 sections
Lipitor HUMAN PRESCRIPTION DRUG LABEL 1 0071-0157 TABLET, FILM COATED 40 mg ORAL NDA 29 sections
Lipitor HUMAN PRESCRIPTION DRUG LABEL 1 0071-0158 TABLET, FILM COATED 80 mg ORAL NDA 29 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5056 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5057 TABLET, FILM COATED 80 mg ORAL ANDA 28 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5058 TABLET, FILM COATED 40 mg ORAL ANDA 28 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5059 TABLET, FILM COATED 20 mg ORAL ANDA 28 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3950 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3951 TABLET, FILM COATED 20 mg ORAL ANDA 29 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3952 TABLET, FILM COATED 40 mg ORAL ANDA 29 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3953 TABLET, FILM COATED 80 mg ORAL ANDA 29 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4510 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4511 TABLET, FILM COATED 20 mg ORAL ANDA 29 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4512 TABLET, FILM COATED 40 mg ORAL ANDA 29 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4513 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4514 TABLET, FILM COATED 20 mg ORAL ANDA 29 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4515 TABLET, FILM COATED 40 mg ORAL ANDA 29 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4516 TABLET, FILM COATED 80 mg ORAL ANDA 29 sections