Stem definition | Drug id | CAS RN |
---|---|---|
antihyperlipidaemic substances, HMG CoA reductase inhibitors | 257 | 134523-00-5 |
Dose | Unit | Route |
---|---|---|
20 | mg | O |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.05 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Hosey CM, Chan R, Benet LZ |
S (Water solubility) | 0.02 mg/mL | Hosey CM, Chan R, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 1 % | Hosey CM, Chan R, Benet LZ |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 17, 1996 | FDA | PFIZER |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myalgia | 1158.18 | 9.67 | 2569 | 331038 | 130922 | 52884537 |
Rhabdomyolysis | 848.34 | 9.67 | 1202 | 332405 | 42721 | 52972738 |
Maternal exposure during pregnancy | 755.77 | 9.67 | 57 | 333550 | 155582 | 52859877 |
Immune-mediated myositis | 719.13 | 9.67 | 268 | 333339 | 838 | 53014621 |
Rheumatoid arthritis | 616.62 | 9.67 | 635 | 332972 | 313896 | 52701563 |
Drug ineffective | 609.83 | 9.67 | 2840 | 330767 | 814405 | 52201054 |
Pemphigus | 583.40 | 9.67 | 14 | 333593 | 104017 | 52911442 |
Exposure during pregnancy | 528.48 | 9.67 | 76 | 333531 | 124784 | 52890675 |
Acute kidney injury | 478.27 | 9.67 | 2966 | 330641 | 250902 | 52764557 |
Systemic lupus erythematosus | 449.15 | 9.67 | 115 | 333492 | 125299 | 52890160 |
Hand deformity | 432.67 | 9.67 | 24 | 333583 | 84825 | 52930634 |
Contraindicated product administered | 432.11 | 9.67 | 154 | 333453 | 135475 | 52879984 |
Myopathy | 421.28 | 9.67 | 403 | 333204 | 9289 | 53006170 |
Glossodynia | 410.77 | 9.67 | 67 | 333540 | 100224 | 52915235 |
Cerebrovascular accident | 397.15 | 9.67 | 1502 | 332105 | 103672 | 52911787 |
Treatment failure | 396.93 | 9.67 | 153 | 333454 | 128250 | 52887209 |
Myocardial infarction | 381.03 | 9.67 | 1426 | 332181 | 97928 | 52917531 |
Blood creatine phosphokinase increased | 373.26 | 9.67 | 659 | 332948 | 28326 | 52987133 |
Off label use | 345.13 | 9.67 | 1650 | 331957 | 470562 | 52544897 |
Synovitis | 336.04 | 9.67 | 127 | 333480 | 107766 | 52907693 |
Anti-cyclic citrullinated peptide antibody positive | 335.73 | 9.67 | 4 | 333603 | 57168 | 52958291 |
Therapeutic product effect decreased | 293.90 | 9.67 | 214 | 333393 | 125441 | 52890018 |
Infusion related reaction | 290.46 | 9.67 | 328 | 333279 | 155629 | 52859830 |
Muscular weakness | 269.32 | 9.67 | 1298 | 332309 | 99694 | 52915765 |
Completed suicide | 258.04 | 9.67 | 290 | 333317 | 137911 | 52877548 |
Acute myocardial infarction | 255.97 | 9.67 | 611 | 332996 | 32624 | 52982835 |
Wound | 242.77 | 9.67 | 135 | 333472 | 91422 | 52924037 |
Necrotising myositis | 238.63 | 9.67 | 89 | 333518 | 279 | 53015180 |
Drug interaction | 237.45 | 9.67 | 2252 | 331355 | 217077 | 52798382 |
Pericarditis | 236.44 | 9.67 | 56 | 333551 | 64350 | 52951109 |
Rheumatoid factor positive | 233.01 | 9.67 | 5 | 333602 | 41193 | 52974266 |
Arthropathy | 213.28 | 9.67 | 347 | 333260 | 141106 | 52874353 |
Drug intolerance | 209.46 | 9.67 | 626 | 332981 | 204867 | 52810592 |
Drug hypersensitivity | 206.58 | 9.67 | 2550 | 331057 | 262692 | 52752767 |
Product use issue | 191.76 | 9.67 | 363 | 333244 | 139221 | 52876238 |
Coronary artery disease | 189.26 | 9.67 | 548 | 333059 | 32889 | 52982570 |
Pain | 182.94 | 9.67 | 2587 | 331020 | 585811 | 52429648 |
Hypomagnesaemia | 179.16 | 9.67 | 445 | 333162 | 24366 | 52991093 |
Alopecia | 178.91 | 9.67 | 806 | 332801 | 233777 | 52781682 |
Muscle spasms | 176.24 | 9.67 | 1443 | 332164 | 133352 | 52882107 |
Duodenal ulcer perforation | 170.30 | 9.67 | 13 | 333594 | 35170 | 52980289 |
Swelling | 166.06 | 9.67 | 624 | 332983 | 190481 | 52824978 |
Hypersensitivity | 161.10 | 9.67 | 723 | 332884 | 209942 | 52805517 |
Abdominal discomfort | 158.86 | 9.67 | 776 | 332831 | 220286 | 52795173 |
Joint swelling | 156.56 | 9.67 | 845 | 332762 | 233793 | 52781666 |
Discomfort | 153.64 | 9.67 | 224 | 333383 | 95248 | 52920211 |
Foetal exposure during pregnancy | 151.86 | 9.67 | 19 | 333588 | 34696 | 52980763 |
Polymyositis | 151.73 | 9.67 | 109 | 333498 | 1655 | 53013804 |
Febrile neutropenia | 147.54 | 9.67 | 269 | 333338 | 104667 | 52910792 |
Fall | 147.51 | 9.67 | 3099 | 330508 | 355341 | 52660118 |
Lactic acidosis | 142.90 | 9.67 | 535 | 333072 | 36718 | 52978741 |
Blood glucose increased | 142.75 | 9.67 | 900 | 332707 | 76461 | 52938998 |
Folliculitis | 139.57 | 9.67 | 17 | 333590 | 31692 | 52983767 |
Helicobacter infection | 137.54 | 9.67 | 37 | 333570 | 39032 | 52976427 |
Hypoglycaemia | 137.21 | 9.67 | 730 | 332877 | 58283 | 52957176 |
Hyperkalaemia | 133.63 | 9.67 | 682 | 332925 | 53574 | 52961885 |
Transient ischaemic attack | 132.03 | 9.67 | 507 | 333100 | 35218 | 52980241 |
Myositis | 130.66 | 9.67 | 209 | 333398 | 8274 | 53007185 |
Abortion spontaneous | 129.13 | 9.67 | 65 | 333542 | 46570 | 52968889 |
Device expulsion | 128.76 | 9.67 | 17 | 333590 | 29796 | 52985663 |
Toxicity to various agents | 128.31 | 9.67 | 825 | 332782 | 218773 | 52796686 |
Pregnancy | 126.47 | 9.67 | 22 | 333585 | 31419 | 52984040 |
Rash | 124.86 | 9.67 | 2001 | 331606 | 444190 | 52571269 |
Infection | 123.94 | 9.67 | 604 | 333003 | 171601 | 52843858 |
Chest pain | 122.00 | 9.67 | 1766 | 331841 | 188419 | 52827040 |
Hyponatraemia | 117.22 | 9.67 | 1115 | 332492 | 107492 | 52907967 |
Drug abuse | 115.27 | 9.67 | 144 | 333463 | 65382 | 52950077 |
Low density lipoprotein increased | 114.91 | 9.67 | 166 | 333441 | 6000 | 53009459 |
Liver function test abnormal | 111.30 | 9.67 | 594 | 333013 | 47477 | 52967982 |
Sinusitis | 109.09 | 9.67 | 613 | 332994 | 167951 | 52847508 |
Angina pectoris | 108.07 | 9.67 | 410 | 333197 | 28315 | 52987144 |
Ischaemic stroke | 107.76 | 9.67 | 301 | 333306 | 17692 | 52997767 |
Atrial fibrillation | 104.93 | 9.67 | 1114 | 332493 | 110538 | 52904921 |
Sleep disorder due to general medical condition, insomnia type | 104.88 | 9.67 | 14 | 333593 | 24335 | 52991124 |
Cardiac failure congestive | 103.94 | 9.67 | 960 | 332647 | 91797 | 52923662 |
Stomatitis | 102.08 | 9.67 | 296 | 333311 | 97862 | 52917597 |
Hypertensive emergency | 101.43 | 9.67 | 85 | 333522 | 1636 | 53013823 |
Angina unstable | 97.67 | 9.67 | 171 | 333436 | 7297 | 53008162 |
Cholestasis | 96.19 | 9.67 | 395 | 333212 | 28300 | 52987159 |
Neurologic neglect syndrome | 95.14 | 9.67 | 70 | 333537 | 1105 | 53014354 |
Malignant neoplasm progression | 94.76 | 9.67 | 190 | 333417 | 71351 | 52944108 |
Carotid artery thrombosis | 94.40 | 9.67 | 71 | 333536 | 1161 | 53014298 |
Impaired healing | 94.38 | 9.67 | 160 | 333447 | 64045 | 52951414 |
Pyrexia | 93.71 | 9.67 | 1868 | 331739 | 401325 | 52614134 |
Autoimmune hepatitis | 93.02 | 9.67 | 178 | 333429 | 8140 | 53007319 |
Irritable bowel syndrome | 92.32 | 9.67 | 82 | 333525 | 43550 | 52971909 |
Hemiplegia | 91.05 | 9.67 | 170 | 333437 | 7630 | 53007829 |
Gastrointestinal haemorrhage | 88.79 | 9.67 | 829 | 332778 | 79501 | 52935958 |
Diabetic ketoacidosis | 87.46 | 9.67 | 299 | 333308 | 19616 | 52995843 |
Drug-induced liver injury | 86.87 | 9.67 | 388 | 333219 | 28845 | 52986614 |
Premature baby | 86.21 | 9.67 | 11 | 333596 | 19790 | 52995669 |
Asthenia | 85.96 | 9.67 | 2782 | 330825 | 340808 | 52674651 |
Neutropenia | 85.95 | 9.67 | 612 | 332995 | 158573 | 52856886 |
Premature delivery | 85.90 | 9.67 | 28 | 333579 | 26076 | 52989383 |
Syncope | 84.50 | 9.67 | 1071 | 332536 | 110922 | 52904537 |
Intentional overdose | 84.37 | 9.67 | 184 | 333423 | 67021 | 52948438 |
Caesarean section | 82.15 | 9.67 | 7 | 333600 | 17313 | 52998146 |
Renal failure | 79.92 | 9.67 | 1110 | 332497 | 117342 | 52898117 |
Coronary artery occlusion | 79.10 | 9.67 | 166 | 333441 | 8121 | 53007338 |
Dizziness | 76.46 | 9.67 | 2947 | 330660 | 369312 | 52646147 |
International normalised ratio increased | 76.21 | 9.67 | 536 | 333071 | 47225 | 52968234 |
Bradycardia | 71.49 | 9.67 | 719 | 332888 | 70337 | 52945122 |
Blood cholesterol increased | 71.18 | 9.67 | 571 | 333036 | 52418 | 52963041 |
Pancreatitis acute | 70.54 | 9.67 | 337 | 333270 | 25772 | 52989687 |
Muscle injury | 70.44 | 9.67 | 50 | 333557 | 29716 | 52985743 |
Myocardial ischaemia | 68.37 | 9.67 | 206 | 333401 | 12638 | 53002821 |
Live birth | 66.45 | 9.67 | 8 | 333599 | 15051 | 53000408 |
Hepatitis cholestatic | 66.36 | 9.67 | 141 | 333466 | 6958 | 53008501 |
Melaena | 66.10 | 9.67 | 358 | 333249 | 28771 | 52986688 |
Intentional self-injury | 65.95 | 9.67 | 38 | 333569 | 25246 | 52990213 |
Glycosylated haemoglobin increased | 65.92 | 9.67 | 191 | 333416 | 11464 | 53003995 |
Ill-defined disorder | 65.74 | 9.67 | 131 | 333476 | 49313 | 52966146 |
Cerebral haemorrhage | 65.61 | 9.67 | 365 | 333242 | 29631 | 52985828 |
Product use in unapproved indication | 65.42 | 9.67 | 422 | 333185 | 111867 | 52903592 |
Adjustment disorder | 65.34 | 9.67 | 70 | 333537 | 1853 | 53013606 |
Hepatic enzyme increased | 65.29 | 9.67 | 491 | 333116 | 125704 | 52889755 |
Rectal haemorrhage | 64.71 | 9.67 | 463 | 333144 | 41018 | 52974441 |
Hepatitis | 64.15 | 9.67 | 397 | 333210 | 33497 | 52981962 |
Condition aggravated | 62.66 | 9.67 | 1398 | 332209 | 295736 | 52719723 |
C-reactive protein increased | 62.63 | 9.67 | 216 | 333391 | 67670 | 52947789 |
Intentional product use issue | 62.04 | 9.67 | 238 | 333369 | 72256 | 52943203 |
Acute coronary syndrome | 62.04 | 9.67 | 174 | 333433 | 10250 | 53005209 |
Muscle necrosis | 62.00 | 9.67 | 41 | 333566 | 540 | 53014919 |
Diabetes mellitus | 60.94 | 9.67 | 559 | 333048 | 53340 | 52962119 |
Pemphigoid | 60.25 | 9.67 | 128 | 333479 | 6316 | 53009143 |
Rheumatic fever | 60.04 | 9.67 | 5 | 333602 | 12599 | 53002860 |
Anaemia | 58.96 | 9.67 | 2200 | 331407 | 274518 | 52740941 |
Decreased appetite | 58.51 | 9.67 | 1759 | 331848 | 213215 | 52802244 |
Swollen joint count increased | 58.13 | 9.67 | 3 | 333604 | 11287 | 53004172 |
Incorrect dosage administered | 57.54 | 9.67 | 64 | 333543 | 1769 | 53013690 |
Blood triglycerides increased | 57.47 | 9.67 | 190 | 333417 | 12251 | 53003208 |
Infective pulmonary exacerbation of cystic fibrosis | 57.33 | 9.67 | 3 | 333604 | 11153 | 53004306 |
Coronary artery stenosis | 56.84 | 9.67 | 106 | 333501 | 4753 | 53010706 |
Labelled drug-drug interaction medication error | 56.32 | 9.67 | 173 | 333434 | 10726 | 53004733 |
Atrioventricular block | 55.75 | 9.67 | 132 | 333475 | 7008 | 53008451 |
Cardiac disorder | 55.08 | 9.67 | 491 | 333116 | 46475 | 52968984 |
Amnesia | 54.95 | 9.67 | 477 | 333130 | 44811 | 52970648 |
Device dislocation | 54.07 | 9.67 | 41 | 333566 | 23556 | 52991903 |
Renal impairment | 53.46 | 9.67 | 774 | 332833 | 82544 | 52932915 |
Hepatitis acute | 52.25 | 9.67 | 148 | 333459 | 8768 | 53006691 |
Injection site reaction | 51.94 | 9.67 | 156 | 333451 | 51010 | 52964449 |
Atrioventricular block complete | 51.90 | 9.67 | 138 | 333469 | 7877 | 53007582 |
Hepatocellular injury | 51.68 | 9.67 | 343 | 333264 | 29643 | 52985816 |
Leukopenia | 51.45 | 9.67 | 260 | 333347 | 73203 | 52942256 |
Chromaturia | 51.44 | 9.67 | 217 | 333390 | 15733 | 52999726 |
Nasopharyngitis | 51.40 | 9.67 | 869 | 332738 | 191426 | 52824033 |
Drug resistance | 50.66 | 9.67 | 31 | 333576 | 19931 | 52995528 |
Gastrointestinal disorder | 50.03 | 9.67 | 343 | 333264 | 89661 | 52925798 |
Haematochezia | 48.74 | 9.67 | 441 | 333166 | 41917 | 52973542 |
Injection site erythema | 48.27 | 9.67 | 284 | 333323 | 76965 | 52938494 |
Hip arthroplasty | 48.19 | 9.67 | 62 | 333545 | 27800 | 52987659 |
Personality disorder | 48.18 | 9.67 | 90 | 333517 | 4041 | 53011418 |
Suicide attempt | 47.21 | 9.67 | 195 | 333412 | 57973 | 52957486 |
Knee arthroplasty | 47.20 | 9.67 | 86 | 333521 | 33483 | 52981976 |
Chronic kidney disease | 47.11 | 9.67 | 446 | 333161 | 42924 | 52972535 |
Jaundice | 47.08 | 9.67 | 338 | 333269 | 29975 | 52985484 |
Oedema peripheral | 46.59 | 9.67 | 1398 | 332209 | 169389 | 52846070 |
Autoimmune myositis | 46.56 | 9.67 | 18 | 333589 | 64 | 53015395 |
Swollen tongue | 46.23 | 9.67 | 343 | 333264 | 30737 | 52984722 |
High density lipoprotein decreased | 46.21 | 9.67 | 58 | 333549 | 1827 | 53013632 |
Therapeutic product effect incomplete | 46.10 | 9.67 | 360 | 333247 | 91424 | 52924035 |
Dysarthria | 45.48 | 9.67 | 420 | 333187 | 40148 | 52975311 |
Pain in extremity | 45.31 | 9.67 | 2198 | 331409 | 282852 | 52732607 |
Premature labour | 44.86 | 9.67 | 11 | 333596 | 12351 | 53003108 |
Cardiac failure | 44.67 | 9.67 | 770 | 332837 | 85074 | 52930385 |
Carotid arteriosclerosis | 44.48 | 9.67 | 43 | 333564 | 1004 | 53014455 |
Blood alkaline phosphatase increased | 44.26 | 9.67 | 424 | 333183 | 40938 | 52974521 |
Mixed liver injury | 43.78 | 9.67 | 84 | 333523 | 3849 | 53011610 |
Hemiparesis | 43.48 | 9.67 | 256 | 333351 | 21219 | 52994240 |
Cytomegalovirus infection | 43.44 | 9.67 | 35 | 333572 | 19504 | 52995955 |
Injection site swelling | 43.24 | 9.67 | 130 | 333477 | 42498 | 52972961 |
Neurotoxicity | 43.08 | 9.67 | 21 | 333586 | 15328 | 53000131 |
Product substitution issue | 43.01 | 9.67 | 205 | 333402 | 15661 | 52999798 |
Injection site pain | 42.65 | 9.67 | 478 | 333129 | 112913 | 52902546 |
Coma | 42.51 | 9.67 | 220 | 333387 | 61563 | 52953896 |
Bone erosion | 42.32 | 9.67 | 9 | 333598 | 11143 | 53004316 |
Labile blood pressure | 41.76 | 9.67 | 55 | 333552 | 1819 | 53013640 |
Red blood cell sedimentation rate abnormal | 41.75 | 9.67 | 23 | 333584 | 15666 | 52999793 |
Muscle atrophy | 41.53 | 9.67 | 110 | 333497 | 6264 | 53009195 |
Diabetes mellitus inadequate control | 41.07 | 9.67 | 188 | 333419 | 14122 | 53001337 |
Hyperlipidaemia | 41.05 | 9.67 | 235 | 333372 | 19280 | 52996179 |
Confusional state | 40.57 | 9.67 | 1541 | 332066 | 192680 | 52822779 |
Pancytopenia | 40.55 | 9.67 | 368 | 333239 | 90560 | 52924899 |
Vascular stent stenosis | 40.40 | 9.67 | 31 | 333576 | 523 | 53014936 |
Carotid artery stenosis | 39.99 | 9.67 | 97 | 333510 | 5230 | 53010229 |
Accidental exposure to product | 39.60 | 9.67 | 54 | 333553 | 23620 | 52991839 |
Mucosal inflammation | 38.87 | 9.67 | 137 | 333470 | 42647 | 52972812 |
Gestational diabetes | 38.82 | 9.67 | 3 | 333604 | 8036 | 53007423 |
Large intestine polyp | 38.61 | 9.67 | 125 | 333482 | 7972 | 53007487 |
Abortion induced | 38.58 | 9.67 | 10 | 333597 | 10816 | 53004643 |
Polymyalgia rheumatica | 38.47 | 9.67 | 65 | 333542 | 2694 | 53012765 |
Psoriatic arthropathy | 38.21 | 9.67 | 163 | 333444 | 48027 | 52967432 |
Musculoskeletal stiffness | 37.85 | 9.67 | 543 | 333064 | 122825 | 52892634 |
Dehydration | 37.78 | 9.67 | 1347 | 332260 | 167063 | 52848396 |
Blood loss anaemia | 37.46 | 9.67 | 131 | 333476 | 8692 | 53006767 |
Hepatitis toxic | 37.34 | 9.67 | 69 | 333538 | 3072 | 53012387 |
Muscle disorder | 37.19 | 9.67 | 86 | 333521 | 4495 | 53010964 |
Pre-eclampsia | 37.17 | 9.67 | 5 | 333602 | 8642 | 53006817 |
Hypocalcaemia | 37.16 | 9.67 | 312 | 333295 | 29025 | 52986434 |
Hyperglycaemia | 36.71 | 9.67 | 398 | 333209 | 39686 | 52975773 |
Macular degeneration | 36.67 | 9.67 | 164 | 333443 | 12197 | 53003262 |
Blister | 36.31 | 9.67 | 316 | 333291 | 78437 | 52937022 |
Death | 36.04 | 9.67 | 1846 | 331761 | 355386 | 52660073 |
Migraine | 35.62 | 9.67 | 326 | 333281 | 80091 | 52935368 |
Gait disturbance | 35.51 | 9.67 | 1270 | 332337 | 157572 | 52857887 |
Arterial stenosis | 35.31 | 9.67 | 31 | 333576 | 637 | 53014822 |
Respiratory depression | 35.22 | 9.67 | 18 | 333589 | 12788 | 53002671 |
Uterine perforation | 35.18 | 9.67 | 3 | 333604 | 7416 | 53008043 |
Haemorrhage intracranial | 35.09 | 9.67 | 171 | 333436 | 13181 | 53002278 |
Sensory loss | 34.98 | 9.67 | 119 | 333488 | 7786 | 53007673 |
Neutrophil count decreased | 34.81 | 9.67 | 173 | 333434 | 48925 | 52966534 |
Low density lipoprotein abnormal | 34.76 | 9.67 | 19 | 333588 | 172 | 53015287 |
Blood cholesterol abnormal | 34.62 | 9.67 | 59 | 333548 | 2463 | 53012996 |
Respiratory arrest | 33.51 | 9.67 | 103 | 333504 | 33437 | 52982022 |
Gamma-glutamyltransferase increased | 33.48 | 9.67 | 339 | 333268 | 33216 | 52982243 |
Product monitoring error | 33.33 | 9.67 | 63 | 333544 | 2854 | 53012605 |
Disease progression | 33.26 | 9.67 | 443 | 333164 | 101477 | 52913982 |
Therapeutic response decreased | 32.94 | 9.67 | 169 | 333438 | 47400 | 52968059 |
Haematoma | 32.85 | 9.67 | 340 | 333267 | 33504 | 52981955 |
Blood pressure increased | 32.84 | 9.67 | 1129 | 332478 | 139350 | 52876109 |
Myelosuppression | 32.44 | 9.67 | 20 | 333587 | 12808 | 53002651 |
Peripheral artery stenosis | 32.11 | 9.67 | 28 | 333579 | 570 | 53014889 |
Dyspnoea | 31.76 | 9.67 | 4156 | 329451 | 582076 | 52433383 |
Lower respiratory tract infection | 31.71 | 9.67 | 390 | 333217 | 90591 | 52924868 |
Blood glucose decreased | 31.55 | 9.67 | 224 | 333383 | 19792 | 52995667 |
Aphasia | 31.21 | 9.67 | 312 | 333295 | 30466 | 52984993 |
Myocardial necrosis marker increased | 31.07 | 9.67 | 45 | 333562 | 1630 | 53013829 |
Upper gastrointestinal haemorrhage | 31.02 | 9.67 | 201 | 333406 | 17229 | 52998230 |
Amenorrhoea | 30.81 | 9.67 | 10 | 333597 | 9339 | 53006120 |
Foetal death | 30.80 | 9.67 | 10 | 333597 | 9337 | 53006122 |
Inappropriate antidiuretic hormone secretion | 30.12 | 9.67 | 178 | 333429 | 14773 | 53000686 |
Body height decreased | 30.01 | 9.67 | 132 | 333475 | 9747 | 53005712 |
Device issue | 29.99 | 9.67 | 56 | 333551 | 21602 | 52993857 |
Subdural haematoma | 29.49 | 9.67 | 167 | 333440 | 13646 | 53001813 |
Ischaemic cardiomyopathy | 29.40 | 9.67 | 56 | 333551 | 2552 | 53012907 |
Myoglobin blood increased | 29.28 | 9.67 | 41 | 333566 | 1439 | 53014020 |
Blood creatine phosphokinase MB increased | 29.06 | 9.67 | 38 | 333569 | 1248 | 53014211 |
Stillbirth | 29.05 | 9.67 | 4 | 333603 | 6793 | 53008666 |
Febrile bone marrow aplasia | 28.98 | 9.67 | 5 | 333602 | 7184 | 53008275 |
Mitral valve incompetence | 28.64 | 9.67 | 215 | 333392 | 19336 | 52996123 |
Angioedema | 28.63 | 9.67 | 395 | 333212 | 41681 | 52973778 |
Alanine aminotransferase increased | 28.55 | 9.67 | 788 | 332819 | 94307 | 52921152 |
Dementia | 28.50 | 9.67 | 191 | 333416 | 16559 | 52998900 |
Orthostatic hypotension | 28.45 | 9.67 | 298 | 333309 | 29455 | 52986004 |
Euglycaemic diabetic ketoacidosis | 28.42 | 9.67 | 60 | 333547 | 2947 | 53012512 |
Cholestatic liver injury | 28.09 | 9.67 | 53 | 333554 | 2398 | 53013061 |
Aldolase increased | 28.00 | 9.67 | 15 | 333592 | 130 | 53015329 |
Myopathy toxic | 27.76 | 9.67 | 22 | 333585 | 390 | 53015069 |
Myoglobinuria | 27.75 | 9.67 | 18 | 333589 | 229 | 53015230 |
Eating disorder | 27.74 | 9.67 | 185 | 333422 | 16012 | 52999447 |
Cell death | 27.72 | 9.67 | 53 | 333554 | 2422 | 53013037 |
Oligohydramnios | 27.38 | 9.67 | 3 | 333604 | 6073 | 53009386 |
Cerebral infarction | 27.36 | 9.67 | 253 | 333354 | 24191 | 52991268 |
Seizure | 27.04 | 9.67 | 610 | 332997 | 128899 | 52886560 |
Aortic stenosis | 26.99 | 9.67 | 76 | 333531 | 4487 | 53010972 |
Arteriosclerosis | 26.94 | 9.67 | 130 | 333477 | 9981 | 53005478 |
Metastases to bone | 26.74 | 9.67 | 50 | 333557 | 19278 | 52996181 |
Weight decreased | 26.64 | 9.67 | 1757 | 331850 | 233191 | 52782268 |
Stent placement | 26.59 | 9.67 | 65 | 333542 | 3522 | 53011937 |
Panniculitis | 26.39 | 9.67 | 8 | 333599 | 7806 | 53007653 |
Dermatomyositis | 26.11 | 9.67 | 51 | 333556 | 2368 | 53013091 |
Acute myeloid leukaemia | 25.99 | 9.67 | 41 | 333566 | 16891 | 52998568 |
Heavy menstrual bleeding | 25.80 | 9.67 | 43 | 333564 | 17333 | 52998126 |
Urine output decreased | 25.79 | 9.67 | 142 | 333465 | 11481 | 53003978 |
Head injury | 25.77 | 9.67 | 261 | 333346 | 25572 | 52989887 |
Device related infection | 25.70 | 9.67 | 66 | 333541 | 22720 | 52992739 |
Haematemesis | 25.37 | 9.67 | 300 | 333307 | 30557 | 52984902 |
Aspartate aminotransferase increased | 25.13 | 9.67 | 696 | 332911 | 83333 | 52932126 |
Faeces discoloured | 25.07 | 9.67 | 193 | 333414 | 17493 | 52997966 |
Diabetic metabolic decompensation | 24.92 | 9.67 | 40 | 333567 | 1588 | 53013871 |
Flatulence | 24.85 | 9.67 | 304 | 333303 | 31213 | 52984246 |
Traumatic coma | 24.61 | 9.67 | 11 | 333596 | 61 | 53015398 |
Lichen planopilaris | 24.49 | 9.67 | 6 | 333601 | 0 | 53015459 |
Maternal drugs affecting foetus | 24.34 | 9.67 | 3 | 333604 | 5543 | 53009916 |
Renal disorder | 24.27 | 9.67 | 284 | 333323 | 28855 | 52986604 |
Subarachnoid haemorrhage | 24.22 | 9.67 | 142 | 333465 | 11751 | 53003708 |
Embolic stroke | 24.18 | 9.67 | 65 | 333542 | 3734 | 53011725 |
Gynaecomastia | 24.10 | 9.67 | 14 | 333593 | 144 | 53015315 |
Intestinal haemorrhage | 24.09 | 9.67 | 61 | 333546 | 3379 | 53012080 |
Hypercholesterolaemia | 23.96 | 9.67 | 148 | 333459 | 12478 | 53002981 |
Anuria | 23.72 | 9.67 | 146 | 333461 | 12294 | 53003165 |
Diabetic nephropathy | 23.59 | 9.67 | 37 | 333570 | 1440 | 53014019 |
Diabetic retinopathy | 23.54 | 9.67 | 49 | 333558 | 2383 | 53013076 |
Mouth swelling | 23.52 | 9.67 | 70 | 333537 | 4265 | 53011194 |
Balance disorder | 23.50 | 9.67 | 612 | 332995 | 72595 | 52942864 |
Pathogen resistance | 23.49 | 9.67 | 6 | 333601 | 6554 | 53008905 |
Blood creatinine increased | 23.42 | 9.67 | 680 | 332927 | 81982 | 52933477 |
Haematotoxicity | 23.41 | 9.67 | 10 | 333597 | 7887 | 53007572 |
Subacute cutaneous lupus erythematosus | 23.26 | 9.67 | 48 | 333559 | 2320 | 53013139 |
Incorrect route of product administration | 23.07 | 9.67 | 54 | 333553 | 19190 | 52996269 |
Ankylosing spondylitis | 22.98 | 9.67 | 11 | 333596 | 8114 | 53007345 |
Hypokalaemia | 22.88 | 9.67 | 777 | 332830 | 95740 | 52919719 |
Hypovolaemic shock | 22.82 | 9.67 | 82 | 333525 | 5515 | 53009944 |
Carotid artery occlusion | 22.75 | 9.67 | 52 | 333555 | 2697 | 53012762 |
Chronic obstructive pulmonary disease | 22.75 | 9.67 | 521 | 333086 | 60552 | 52954907 |
Liver disorder | 22.65 | 9.67 | 365 | 333242 | 39790 | 52975669 |
Fibromyalgia | 22.53 | 9.67 | 172 | 333435 | 43903 | 52971556 |
Hepatic ischaemia | 22.44 | 9.67 | 24 | 333583 | 634 | 53014825 |
Hypovolaemia | 22.36 | 9.67 | 126 | 333481 | 10276 | 53005183 |
Injection site pruritus | 22.36 | 9.67 | 160 | 333447 | 41429 | 52974030 |
Coronary artery thrombosis | 22.17 | 9.67 | 33 | 333574 | 1226 | 53014233 |
Haemophagocytic lymphohistiocytosis | 22.08 | 9.67 | 15 | 333592 | 9122 | 53006337 |
Rheumatoid nodule | 22.00 | 9.67 | 25 | 333582 | 11839 | 53003620 |
Suicidal ideation | 21.99 | 9.67 | 257 | 333350 | 60254 | 52955205 |
Mydriasis | 21.96 | 9.67 | 23 | 333584 | 11303 | 53004156 |
Malaise | 21.86 | 9.67 | 2555 | 331052 | 355062 | 52660397 |
Pallor | 21.67 | 9.67 | 247 | 333360 | 24935 | 52990524 |
Transplant rejection | 21.56 | 9.67 | 19 | 333588 | 10132 | 53005327 |
Motor dysfunction | 21.48 | 9.67 | 106 | 333501 | 8212 | 53007247 |
Metastases to liver | 21.48 | 9.67 | 66 | 333541 | 21430 | 52994029 |
Thrombocytopenia | 21.47 | 9.67 | 682 | 332925 | 138045 | 52877414 |
Enthesopathy | 21.39 | 9.67 | 7 | 333600 | 6504 | 53008955 |
Presyncope | 21.24 | 9.67 | 254 | 333353 | 25940 | 52989519 |
Affect lability | 21.11 | 9.67 | 115 | 333492 | 9260 | 53006199 |
Multiple sclerosis relapse | 21.10 | 9.67 | 179 | 333428 | 44674 | 52970785 |
Eosinophilia | 21.02 | 9.67 | 215 | 333392 | 21120 | 52994339 |
Cardiac murmur | 20.97 | 9.67 | 137 | 333470 | 11776 | 53003683 |
Ocular myasthenia | 20.90 | 9.67 | 13 | 333594 | 153 | 53015306 |
Psychotic disorder | 20.89 | 9.67 | 80 | 333527 | 24305 | 52991154 |
Retinal artery occlusion | 20.68 | 9.67 | 37 | 333570 | 1606 | 53013853 |
Hepatic function abnormal | 20.66 | 9.67 | 335 | 333272 | 36564 | 52978895 |
Coronary artery bypass | 20.65 | 9.67 | 47 | 333560 | 2431 | 53013028 |
Tenosynovitis | 20.64 | 9.67 | 19 | 333588 | 9920 | 53005539 |
Complication of device insertion | 20.61 | 9.67 | 6 | 333601 | 6011 | 53009448 |
Antimitochondrial antibody positive | 20.57 | 9.67 | 10 | 333597 | 69 | 53015390 |
Food allergy | 20.52 | 9.67 | 13 | 333594 | 8205 | 53007254 |
Immunodeficiency | 20.46 | 9.67 | 39 | 333568 | 14928 | 53000531 |
Blood creatine phosphokinase abnormal | 20.43 | 9.67 | 15 | 333592 | 236 | 53015223 |
Overdose | 20.40 | 9.67 | 515 | 333092 | 107221 | 52908238 |
Dysphagia | 20.40 | 9.67 | 681 | 332926 | 83716 | 52931743 |
Lymphocyte count decreased | 20.37 | 9.67 | 98 | 333509 | 27954 | 52987505 |
Acne | 20.37 | 9.67 | 68 | 333539 | 21518 | 52993941 |
Peripheral nerve palsy | 20.34 | 9.67 | 7 | 333600 | 16 | 53015443 |
Candida infection | 20.33 | 9.67 | 85 | 333522 | 25188 | 52990271 |
Cerebral haematoma | 20.27 | 9.67 | 58 | 333549 | 3456 | 53012003 |
Extraocular muscle paresis | 20.27 | 9.67 | 13 | 333594 | 162 | 53015297 |
Duodenal ulcer | 20.22 | 9.67 | 98 | 333509 | 7538 | 53007921 |
Stevens-Johnson syndrome | 20.20 | 9.67 | 82 | 333525 | 24500 | 52990959 |
Glomerular filtration rate decreased | 20.19 | 9.67 | 143 | 333464 | 12624 | 53002835 |
Therapeutic drug monitoring analysis not performed | 20.00 | 9.67 | 24 | 333583 | 721 | 53014738 |
Chloropsia | 19.97 | 9.67 | 8 | 333599 | 32 | 53015427 |
Sinus bradycardia | 19.96 | 9.67 | 158 | 333449 | 14443 | 53001016 |
Pulmonary renal syndrome | 19.95 | 9.67 | 18 | 333589 | 384 | 53015075 |
Pancreatitis | 19.87 | 9.67 | 402 | 333205 | 45740 | 52969719 |
Cerebral microangiopathy | 19.85 | 9.67 | 15 | 333592 | 247 | 53015212 |
Bone marrow failure | 19.73 | 9.67 | 109 | 333498 | 30006 | 52985453 |
Hepatic steatosis | 19.73 | 9.67 | 251 | 333356 | 26008 | 52989451 |
Peripheral arterial occlusive disease | 19.72 | 9.67 | 62 | 333545 | 3892 | 53011567 |
Metastases to central nervous system | 19.66 | 9.67 | 28 | 333579 | 12029 | 53003430 |
Hypertensive cardiomyopathy | 19.60 | 9.67 | 15 | 333592 | 252 | 53015207 |
Dyslipidaemia | 19.57 | 9.67 | 85 | 333522 | 6242 | 53009217 |
Grip strength decreased | 19.45 | 9.67 | 27 | 333580 | 11722 | 53003737 |
Cervix neoplasm | 19.35 | 9.67 | 14 | 333593 | 215 | 53015244 |
Urinary tract obstruction | 19.22 | 9.67 | 39 | 333568 | 1862 | 53013597 |
Hypertransaminasaemia | 19.15 | 9.67 | 62 | 333545 | 3954 | 53011505 |
Unintentional medical device removal | 19.14 | 9.67 | 5 | 333602 | 5381 | 53010078 |
Gastric ulcer | 19.12 | 9.67 | 227 | 333380 | 23142 | 52992317 |
Dysstasia | 19.07 | 9.67 | 193 | 333414 | 18906 | 52996553 |
Memory impairment | 19.00 | 9.67 | 678 | 332929 | 84079 | 52931380 |
Loss of personal independence in daily activities | 18.79 | 9.67 | 315 | 333292 | 69500 | 52945959 |
Tuberculosis | 18.77 | 9.67 | 25 | 333582 | 11046 | 53004413 |
Urinary tract discomfort | 18.63 | 9.67 | 13 | 333594 | 188 | 53015271 |
Aspergillus infection | 18.53 | 9.67 | 12 | 333595 | 7484 | 53007975 |
Periorbital haematoma | 18.52 | 9.67 | 24 | 333583 | 781 | 53014678 |
Ascites | 18.50 | 9.67 | 159 | 333448 | 39576 | 52975883 |
Arteriovenous fistula occlusion | 18.34 | 9.67 | 17 | 333590 | 376 | 53015083 |
Left atrial enlargement | 18.28 | 9.67 | 15 | 333592 | 280 | 53015179 |
Epstein-Barr virus infection | 18.16 | 9.67 | 12 | 333595 | 7406 | 53008053 |
Eructation | 18.13 | 9.67 | 97 | 333510 | 7758 | 53007701 |
Arterial occlusive disease | 18.11 | 9.67 | 71 | 333536 | 4978 | 53010481 |
Abnormal dreams | 18.11 | 9.67 | 121 | 333486 | 10480 | 53004979 |
Diverticulum | 18.09 | 9.67 | 131 | 333476 | 11648 | 53003811 |
Lipids abnormal | 18.02 | 9.67 | 15 | 333592 | 286 | 53015173 |
Gastrointestinal toxicity | 17.93 | 9.67 | 68 | 333539 | 4694 | 53010765 |
Menstruation irregular | 17.89 | 9.67 | 11 | 333596 | 7055 | 53008404 |
Rectal polyp | 17.74 | 9.67 | 26 | 333581 | 952 | 53014507 |
Poisoning deliberate | 17.69 | 9.67 | 17 | 333590 | 8696 | 53006763 |
Hallucination, gustatory | 17.62 | 9.67 | 9 | 333598 | 70 | 53015389 |
Cardiotoxicity | 17.61 | 9.67 | 12 | 333595 | 7287 | 53008172 |
Cardiac failure acute | 17.52 | 9.67 | 107 | 333500 | 8985 | 53006474 |
Haematuria | 17.52 | 9.67 | 262 | 333345 | 28127 | 52987332 |
Calcium deficiency | 17.40 | 9.67 | 26 | 333581 | 969 | 53014490 |
Blood urea increased | 17.34 | 9.67 | 245 | 333362 | 25986 | 52989473 |
Poisoning | 17.31 | 9.67 | 38 | 333569 | 13812 | 53001647 |
Low birth weight baby | 17.29 | 9.67 | 9 | 333598 | 6328 | 53009131 |
Intermittent claudication | 17.23 | 9.67 | 37 | 333570 | 1839 | 53013620 |
Lower gastrointestinal haemorrhage | 17.17 | 9.67 | 93 | 333514 | 7473 | 53007986 |
Angiopathy | 17.10 | 9.67 | 64 | 333543 | 4390 | 53011069 |
Coronary artery restenosis | 17.07 | 9.67 | 17 | 333590 | 412 | 53015047 |
Electrocardiogram abnormal | 17.03 | 9.67 | 98 | 333509 | 8055 | 53007404 |
Sedation | 17.02 | 9.67 | 112 | 333495 | 29563 | 52985896 |
Device difficult to use | 16.95 | 9.67 | 24 | 333583 | 10335 | 53005124 |
Breast cancer metastatic | 16.83 | 9.67 | 45 | 333562 | 15283 | 53000176 |
Menstrual disorder | 16.82 | 9.67 | 4 | 333603 | 4586 | 53010873 |
Blood pressure inadequately controlled | 16.77 | 9.67 | 68 | 333539 | 4843 | 53010616 |
Epistaxis | 16.75 | 9.67 | 555 | 333052 | 68155 | 52947304 |
Apolipoprotein A-I decreased | 16.74 | 9.67 | 7 | 333600 | 32 | 53015427 |
White blood cell count decreased | 16.69 | 9.67 | 623 | 332984 | 123852 | 52891607 |
Heart injury | 16.67 | 9.67 | 28 | 333579 | 1155 | 53014304 |
Albuminuria | 16.66 | 9.67 | 13 | 333594 | 225 | 53015234 |
Hypophagia | 16.65 | 9.67 | 280 | 333327 | 30782 | 52984677 |
Dysgeusia | 16.54 | 9.67 | 368 | 333239 | 42563 | 52972896 |
Spur cell anaemia | 16.53 | 9.67 | 6 | 333601 | 17 | 53015442 |
Inclusion body myositis | 16.50 | 9.67 | 5 | 333602 | 6 | 53015453 |
Haemorrhagic transformation stroke | 16.41 | 9.67 | 28 | 333579 | 1170 | 53014289 |
Muscle relaxant therapy | 16.33 | 9.67 | 12 | 333595 | 189 | 53015270 |
Cholangiolitis | 16.32 | 9.67 | 4 | 333603 | 0 | 53015459 |
Post viral fatigue syndrome | 16.25 | 9.67 | 11 | 333596 | 151 | 53015308 |
Normochromic normocytic anaemia | 16.24 | 9.67 | 65 | 333542 | 4601 | 53010858 |
No adverse event | 16.18 | 9.67 | 162 | 333445 | 39103 | 52976356 |
Hepatorenal syndrome | 16.17 | 9.67 | 38 | 333569 | 2007 | 53013452 |
Lipoprotein (a) increased | 16.08 | 9.67 | 7 | 333600 | 36 | 53015423 |
Flushing | 16.05 | 9.67 | 328 | 333279 | 70272 | 52945187 |
Interstitial lung disease | 15.99 | 9.67 | 480 | 333127 | 58142 | 52957317 |
Mobility decreased | 15.98 | 9.67 | 359 | 333248 | 75912 | 52939547 |
Palmar-plantar erythrodysaesthesia syndrome | 15.97 | 9.67 | 75 | 333532 | 21531 | 52993928 |
Blood creatinine abnormal | 15.90 | 9.67 | 46 | 333561 | 2758 | 53012701 |
Immune reconstitution inflammatory syndrome | 15.90 | 9.67 | 10 | 333597 | 6336 | 53009123 |
Pelvic pain | 15.90 | 9.67 | 33 | 333574 | 12240 | 53003219 |
Diverticulum intestinal | 15.84 | 9.67 | 82 | 333525 | 6475 | 53008984 |
Acute pulmonary oedema | 15.81 | 9.67 | 97 | 333510 | 8158 | 53007301 |
Abnormal loss of weight | 15.73 | 9.67 | 71 | 333536 | 5301 | 53010158 |
Cardiac discomfort | 15.68 | 9.67 | 23 | 333584 | 843 | 53014616 |
Neoplasm progression | 15.65 | 9.67 | 116 | 333491 | 29803 | 52985656 |
Plasma cell myeloma | 15.64 | 9.67 | 208 | 333399 | 47666 | 52967793 |
Headache | 15.60 | 9.67 | 3040 | 330567 | 533781 | 52481678 |
Pulmonary toxicity | 15.60 | 9.67 | 71 | 333536 | 5320 | 53010139 |
Chest wall haematoma | 15.59 | 9.67 | 11 | 333596 | 162 | 53015297 |
Ventricular septal defect | 15.54 | 9.67 | 4 | 333603 | 4346 | 53011113 |
Blue toe syndrome | 15.44 | 9.67 | 16 | 333591 | 407 | 53015052 |
Electrocardiogram QT prolonged | 15.43 | 9.67 | 462 | 333145 | 55941 | 52959518 |
Spinal epidural haematoma | 15.38 | 9.67 | 23 | 333584 | 858 | 53014601 |
Bacteraemia | 15.35 | 9.67 | 48 | 333559 | 15501 | 52999958 |
Hepatic cytolysis | 15.32 | 9.67 | 93 | 333514 | 7792 | 53007667 |
Tongue oedema | 15.30 | 9.67 | 60 | 333547 | 4207 | 53011252 |
Tumour lysis syndrome | 15.26 | 9.67 | 16 | 333591 | 7858 | 53007601 |
Lip swelling | 15.24 | 9.67 | 247 | 333360 | 26954 | 52988505 |
Cerebral ischaemia | 15.17 | 9.67 | 82 | 333525 | 6583 | 53008876 |
Procedural hypertension | 15.14 | 9.67 | 13 | 333594 | 259 | 53015200 |
Saliva altered | 15.09 | 9.67 | 14 | 333593 | 310 | 53015149 |
Fatigue | 15.03 | 9.67 | 4205 | 329402 | 726301 | 52289158 |
Microcytic anaemia | 15.02 | 9.67 | 51 | 333556 | 3334 | 53012125 |
Inflammation | 14.98 | 9.67 | 259 | 333348 | 56877 | 52958582 |
Blood electrolytes abnormal | 14.97 | 9.67 | 25 | 333582 | 1026 | 53014433 |
Quadriplegia | 14.97 | 9.67 | 35 | 333572 | 1843 | 53013616 |
Aplastic anaemia | 14.93 | 9.67 | 18 | 333589 | 8303 | 53007156 |
Arthralgia | 14.89 | 9.67 | 2470 | 331137 | 437313 | 52578146 |
Oral herpes | 14.80 | 9.67 | 75 | 333532 | 21104 | 52994355 |
Ear infection | 14.73 | 9.67 | 98 | 333509 | 25802 | 52989657 |
Carotid artery disease | 14.69 | 9.67 | 33 | 333574 | 1692 | 53013767 |
Staphylococcal infection | 14.68 | 9.67 | 162 | 333445 | 38386 | 52977073 |
IIIrd nerve paresis | 14.67 | 9.67 | 10 | 333597 | 139 | 53015320 |
Fear of eating | 14.59 | 9.67 | 15 | 333592 | 378 | 53015081 |
Fungal infection | 14.59 | 9.67 | 130 | 333477 | 32116 | 52983343 |
Ecchymosis | 14.57 | 9.67 | 119 | 333488 | 10980 | 53004479 |
Coordination abnormal | 14.55 | 9.67 | 126 | 333481 | 11825 | 53003634 |
Unintended pregnancy | 14.54 | 9.67 | 10 | 333597 | 6043 | 53009416 |
Transaminases increased | 14.50 | 9.67 | 267 | 333340 | 29865 | 52985594 |
Vascular stent occlusion | 14.44 | 9.67 | 7 | 333600 | 48 | 53015411 |
Urinary occult blood positive | 14.44 | 9.67 | 7 | 333600 | 48 | 53015411 |
Vascular stenosis | 14.38 | 9.67 | 13 | 333594 | 278 | 53015181 |
Ventricular hypertrophy | 14.37 | 9.67 | 54 | 333553 | 3711 | 53011748 |
Arterial insufficiency | 14.31 | 9.67 | 10 | 333597 | 145 | 53015314 |
Bronchopulmonary aspergillosis | 14.25 | 9.67 | 20 | 333587 | 8645 | 53006814 |
Large intestinal haemorrhage | 14.19 | 9.67 | 27 | 333580 | 1229 | 53014230 |
Cytokine release syndrome | 14.15 | 9.67 | 18 | 333589 | 8111 | 53007348 |
Ketoacidosis | 14.10 | 9.67 | 60 | 333547 | 4366 | 53011093 |
Adverse drug reaction | 14.08 | 9.67 | 243 | 333364 | 53382 | 52962077 |
Prothrombin consumption time prolonged | 14.08 | 9.67 | 7 | 333600 | 51 | 53015408 |
Myelodysplastic syndrome | 14.05 | 9.67 | 55 | 333552 | 16605 | 52998854 |
Blood lactic acid | 14.04 | 9.67 | 9 | 333598 | 112 | 53015347 |
Asthma | 14.04 | 9.67 | 548 | 333059 | 108424 | 52907035 |
Acute left ventricular failure | 14.01 | 9.67 | 22 | 333585 | 857 | 53014602 |
Electrolyte imbalance | 13.97 | 9.67 | 180 | 333427 | 18704 | 52996755 |
Muscle fatigue | 13.94 | 9.67 | 39 | 333568 | 2294 | 53013165 |
Vertigo | 13.93 | 9.67 | 454 | 333153 | 55627 | 52959832 |
Acute respiratory distress syndrome | 13.93 | 9.67 | 87 | 333520 | 23245 | 52992214 |
Jaundice hepatocellular | 13.92 | 9.67 | 6 | 333601 | 30 | 53015429 |
Cholecystitis chronic | 13.86 | 9.67 | 28 | 333579 | 10490 | 53004969 |
Glomerular filtration rate abnormal | 13.86 | 9.67 | 18 | 333589 | 587 | 53014872 |
Percutaneous coronary intervention | 13.85 | 9.67 | 10 | 333597 | 153 | 53015306 |
Device adhesion issue | 13.85 | 9.67 | 3 | 333604 | 3667 | 53011792 |
Device deployment issue | 13.81 | 9.67 | 3 | 333604 | 3661 | 53011798 |
Injection site rash | 13.81 | 9.67 | 55 | 333552 | 16524 | 52998935 |
Peripheral vascular disorder | 13.81 | 9.67 | 75 | 333532 | 6033 | 53009426 |
Disorientation | 13.80 | 9.67 | 333 | 333274 | 39026 | 52976433 |
Neurosensory hypoacusis | 13.71 | 9.67 | 13 | 333594 | 296 | 53015163 |
Muscle enzyme increased | 13.64 | 9.67 | 9 | 333598 | 118 | 53015341 |
Biliary fibrosis | 13.58 | 9.67 | 4 | 333603 | 4 | 53015455 |
Copper metabolism disorder | 13.58 | 9.67 | 4 | 333603 | 4 | 53015455 |
Cardiac operation | 13.56 | 9.67 | 44 | 333563 | 2809 | 53012650 |
Cardiac valve disease | 13.46 | 9.67 | 58 | 333549 | 4244 | 53011215 |
Coronary artery surgery | 13.43 | 9.67 | 7 | 333600 | 57 | 53015402 |
Colitis ischaemic | 13.43 | 9.67 | 115 | 333492 | 10759 | 53004700 |
Cerebral mass effect | 13.41 | 9.67 | 22 | 333585 | 890 | 53014569 |
Blood sodium decreased | 13.36 | 9.67 | 211 | 333396 | 22905 | 52992554 |
Lipids increased | 13.34 | 9.67 | 25 | 333582 | 1125 | 53014334 |
Polyuria | 13.33 | 9.67 | 90 | 333517 | 7821 | 53007638 |
Subchondral insufficiency fracture | 13.33 | 9.67 | 7 | 333600 | 58 | 53015401 |
Acidosis | 13.30 | 9.67 | 119 | 333488 | 11273 | 53004186 |
Hypertensive angiopathy | 13.24 | 9.67 | 8 | 333599 | 89 | 53015370 |
Complication associated with device | 13.23 | 9.67 | 54 | 333553 | 16111 | 52999348 |
Jaundice cholestatic | 13.22 | 9.67 | 69 | 333538 | 5465 | 53009994 |
Hypocapnia | 13.21 | 9.67 | 14 | 333593 | 366 | 53015093 |
Renovascular hypertension | 13.10 | 9.67 | 5 | 333602 | 17 | 53015442 |
Respiratory disorder | 13.10 | 9.67 | 143 | 333464 | 33954 | 52981505 |
Thalamus haemorrhage | 13.09 | 9.67 | 18 | 333589 | 621 | 53014838 |
Cardio-respiratory arrest | 13.05 | 9.67 | 274 | 333333 | 58484 | 52956975 |
Progressive multifocal leukoencephalopathy | 13.02 | 9.67 | 36 | 333571 | 12093 | 53003366 |
Bladder sphincter atony | 13.02 | 9.67 | 10 | 333597 | 169 | 53015290 |
Cardiac pacemaker insertion | 13.00 | 9.67 | 53 | 333554 | 3784 | 53011675 |
Muscle haemorrhage | 12.99 | 9.67 | 49 | 333558 | 3374 | 53012085 |
Platelet count decreased | 12.99 | 9.67 | 548 | 333059 | 107551 | 52907908 |
Generalised tonic-clonic seizure | 12.98 | 9.67 | 116 | 333491 | 28642 | 52986817 |
Internal haemorrhage | 12.96 | 9.67 | 61 | 333546 | 4635 | 53010824 |
Low density lipoprotein decreased | 12.94 | 9.67 | 11 | 333596 | 216 | 53015243 |
Tubulointerstitial nephritis | 12.93 | 9.67 | 159 | 333448 | 16345 | 52999114 |
Macular oedema | 12.92 | 9.67 | 56 | 333551 | 4109 | 53011350 |
Blood iron decreased | 12.90 | 9.67 | 125 | 333482 | 12103 | 53003356 |
Posture abnormal | 12.87 | 9.67 | 38 | 333569 | 2305 | 53013154 |
High density lipoprotein abnormal | 12.84 | 9.67 | 7 | 333600 | 63 | 53015396 |
Fine motor skill dysfunction | 12.76 | 9.67 | 5 | 333602 | 4154 | 53011305 |
Vascular purpura | 12.76 | 9.67 | 28 | 333579 | 1413 | 53014046 |
Myoglobinaemia | 12.68 | 9.67 | 5 | 333602 | 19 | 53015440 |
Tubulointerstitial nephritis and uveitis syndrome | 12.63 | 9.67 | 10 | 333597 | 177 | 53015282 |
Gastric ulcer haemorrhage | 12.59 | 9.67 | 64 | 333543 | 5018 | 53010441 |
Nail bed inflammation | 12.56 | 9.67 | 14 | 333593 | 388 | 53015071 |
Product prescribing error | 12.48 | 9.67 | 208 | 333399 | 22823 | 52992636 |
Xanthelasma | 12.48 | 9.67 | 7 | 333600 | 67 | 53015392 |
Blood pressure systolic increased | 12.45 | 9.67 | 298 | 333309 | 34879 | 52980580 |
Glucose urine present | 12.45 | 9.67 | 19 | 333588 | 722 | 53014737 |
Myasthenia gravis | 12.43 | 9.67 | 53 | 333554 | 3860 | 53011599 |
Wrong dose | 12.42 | 9.67 | 21 | 333586 | 871 | 53014588 |
Diverticulum oesophageal | 12.40 | 9.67 | 9 | 333598 | 139 | 53015320 |
Diabetic neuropathy | 12.38 | 9.67 | 54 | 333553 | 3973 | 53011486 |
Renal injury | 12.37 | 9.67 | 105 | 333502 | 9799 | 53005660 |
Hypertension | 12.36 | 9.67 | 1600 | 332007 | 223831 | 52791628 |
Dyspnoea exertional | 12.33 | 9.67 | 440 | 333167 | 54560 | 52960899 |
BRASH syndrome | 12.26 | 9.67 | 10 | 333597 | 185 | 53015274 |
Vaginal haemorrhage | 12.23 | 9.67 | 108 | 333499 | 26733 | 52988726 |
Gait inability | 12.21 | 9.67 | 320 | 333287 | 37991 | 52977468 |
Anal polyp | 12.15 | 9.67 | 6 | 333601 | 43 | 53015416 |
Tobacco abuse | 12.15 | 9.67 | 18 | 333589 | 666 | 53014793 |
Cataract | 12.14 | 9.67 | 401 | 333206 | 49219 | 52966240 |
Blood calcitonin increased | 12.11 | 9.67 | 5 | 333602 | 22 | 53015437 |
Gait deviation | 12.05 | 9.67 | 7 | 333600 | 72 | 53015387 |
Collagen disorder | 12.00 | 9.67 | 10 | 333597 | 191 | 53015268 |
Blood iron abnormal | 12.00 | 9.67 | 3 | 333604 | 3324 | 53012135 |
Administration site discomfort | 11.99 | 9.67 | 8 | 333599 | 107 | 53015352 |
Incision site haemorrhage | 11.97 | 9.67 | 16 | 333591 | 537 | 53014922 |
Mixed anxiety and depressive disorder | 11.95 | 9.67 | 10 | 333597 | 192 | 53015267 |
Urinary tract infection | 11.95 | 9.67 | 1693 | 331914 | 238210 | 52777249 |
Granulomatous dermatitis | 11.93 | 9.67 | 8 | 333599 | 108 | 53015351 |
Parkinsonian rest tremor | 11.93 | 9.67 | 8 | 333599 | 108 | 53015351 |
Nuchal rigidity | 11.88 | 9.67 | 17 | 333590 | 609 | 53014850 |
Genital haemorrhage | 11.85 | 9.67 | 16 | 333591 | 7028 | 53008431 |
Renal artery stenosis | 11.84 | 9.67 | 32 | 333575 | 1844 | 53013615 |
Soft tissue disorder | 11.84 | 9.67 | 6 | 333601 | 4284 | 53011175 |
Arteriosclerosis coronary artery | 11.84 | 9.67 | 92 | 333515 | 8362 | 53007097 |
Colitis ulcerative | 11.82 | 9.67 | 80 | 333527 | 20981 | 52994478 |
Injury | 11.82 | 9.67 | 236 | 333371 | 50735 | 52964724 |
Hypergammaglobulinaemia | 11.82 | 9.67 | 15 | 333592 | 478 | 53014981 |
Shock haemorrhagic | 11.81 | 9.67 | 98 | 333509 | 9085 | 53006374 |
Central nervous system lesion | 11.80 | 9.67 | 29 | 333578 | 10133 | 53005326 |
Pollakiuria | 11.76 | 9.67 | 227 | 333380 | 25612 | 52989847 |
Electrocardiogram Q wave abnormal | 11.73 | 9.67 | 7 | 333600 | 76 | 53015383 |
Muscle contracture | 11.72 | 9.67 | 26 | 333581 | 1322 | 53014137 |
Ligament sprain | 11.71 | 9.67 | 114 | 333493 | 11052 | 53004407 |
Crystal urine | 11.71 | 9.67 | 6 | 333601 | 47 | 53015412 |
Injection site warmth | 11.69 | 9.67 | 47 | 333560 | 14081 | 53001378 |
Neurofibrosarcoma | 11.67 | 9.67 | 9 | 333598 | 153 | 53015306 |
Adenovirus infection | 11.65 | 9.67 | 3 | 333604 | 3259 | 53012200 |
Lipohypertrophy | 11.62 | 9.67 | 19 | 333588 | 766 | 53014693 |
Device breakage | 11.62 | 9.67 | 31 | 333576 | 10536 | 53004923 |
Atrial flutter | 11.62 | 9.67 | 101 | 333506 | 9490 | 53005969 |
Dairy intolerance | 11.60 | 9.67 | 6 | 333601 | 48 | 53015411 |
Prevertebral soft tissue swelling of cervical space | 11.60 | 9.67 | 6 | 333601 | 48 | 53015411 |
Duodenitis | 11.59 | 9.67 | 48 | 333559 | 3451 | 53012008 |
Lipoma | 11.58 | 9.67 | 36 | 333571 | 2246 | 53013213 |
Aspartate aminotransferase | 11.58 | 9.67 | 7 | 333600 | 78 | 53015381 |
Sinus node dysfunction | 11.57 | 9.67 | 56 | 333551 | 4305 | 53011154 |
Mammogram abnormal | 11.52 | 9.67 | 18 | 333589 | 698 | 53014761 |
Deformity | 11.52 | 9.67 | 20 | 333587 | 7934 | 53007525 |
Ventricular internal diameter abnormal | 11.50 | 9.67 | 6 | 333601 | 49 | 53015410 |
International normalised ratio abnormal | 11.48 | 9.67 | 44 | 333563 | 3053 | 53012406 |
Hypertensive crisis | 11.47 | 9.67 | 140 | 333467 | 14366 | 53001093 |
Dementia Alzheimer's type | 11.45 | 9.67 | 24 | 333583 | 1173 | 53014286 |
Acute cutaneous lupus erythematosus | 11.44 | 9.67 | 11 | 333596 | 255 | 53015204 |
Pneumocystis jirovecii pneumonia | 11.44 | 9.67 | 58 | 333549 | 16320 | 52999139 |
Ageusia | 11.43 | 9.67 | 125 | 333482 | 12489 | 53002970 |
Schizophrenia | 11.42 | 9.67 | 30 | 333577 | 10249 | 53005210 |
Bundle branch block left | 11.35 | 9.67 | 79 | 333528 | 6934 | 53008525 |
Atrial septal defect | 11.33 | 9.67 | 16 | 333591 | 6898 | 53008561 |
Lethargy | 11.31 | 9.67 | 427 | 333180 | 53333 | 52962126 |
Narrow anterior chamber angle | 11.30 | 9.67 | 6 | 333601 | 51 | 53015408 |
Ovarian cyst | 11.29 | 9.67 | 53 | 333554 | 15216 | 53000243 |
Speech disorder | 11.28 | 9.67 | 323 | 333284 | 38858 | 52976601 |
Parapsoriasis | 11.27 | 9.67 | 8 | 333599 | 119 | 53015340 |
Lymphomatoid papulosis | 11.27 | 9.67 | 8 | 333599 | 119 | 53015340 |
Fear of injection | 11.23 | 9.67 | 11 | 333596 | 5578 | 53009881 |
Ear congestion | 11.21 | 9.67 | 33 | 333574 | 1998 | 53013461 |
Gastroduodenal haemorrhage | 11.21 | 9.67 | 7 | 333600 | 83 | 53015376 |
Amylase increased | 11.21 | 9.67 | 70 | 333537 | 5924 | 53009535 |
Binocular eye movement disorder | 11.14 | 9.67 | 5 | 333602 | 28 | 53015431 |
Hypotension | 11.12 | 9.67 | 1780 | 331827 | 252296 | 52763163 |
Vascular graft | 11.10 | 9.67 | 19 | 333588 | 796 | 53014663 |
Pneumonia | 11.10 | 9.67 | 2313 | 331294 | 404856 | 52610603 |
Multiple injuries | 11.04 | 9.67 | 32 | 333575 | 1921 | 53013538 |
Vascular device infection | 11.03 | 9.67 | 7 | 333600 | 4414 | 53011045 |
Connective tissue inflammation | 11.01 | 9.67 | 6 | 333601 | 54 | 53015405 |
Albumin urine present | 10.97 | 9.67 | 11 | 333596 | 269 | 53015190 |
Lacunar stroke | 10.94 | 9.67 | 8 | 333599 | 125 | 53015334 |
Bifascicular block | 10.94 | 9.67 | 8 | 333599 | 125 | 53015334 |
Myeloma cast nephropathy | 10.89 | 9.67 | 8 | 333599 | 126 | 53015333 |
Haemorrhagic cyst | 10.88 | 9.67 | 9 | 333598 | 170 | 53015289 |
Quadrantanopia | 10.86 | 9.67 | 5 | 333602 | 30 | 53015429 |
Pneumonia aspiration | 10.85 | 9.67 | 150 | 333457 | 34151 | 52981308 |
Post transplant lymphoproliferative disorder | 10.80 | 9.67 | 7 | 333600 | 4364 | 53011095 |
Troponin T increased | 10.78 | 9.67 | 21 | 333586 | 973 | 53014486 |
Crohn's disease | 10.69 | 9.67 | 16 | 333591 | 6734 | 53008725 |
Hepatocellular carcinoma | 10.68 | 9.67 | 3 | 333604 | 3077 | 53012382 |
Musculoskeletal chest pain | 10.65 | 9.67 | 178 | 333429 | 19544 | 52995915 |
Bladder neoplasm | 10.64 | 9.67 | 15 | 333592 | 530 | 53014929 |
Urine potassium decreased | 10.62 | 9.67 | 4 | 333603 | 13 | 53015446 |
Facial paralysis | 10.61 | 9.67 | 134 | 333473 | 13859 | 53001600 |
N-terminal prohormone brain natriuretic peptide increased | 10.57 | 9.67 | 31 | 333576 | 1873 | 53013586 |
Wrong technique in product usage process | 10.56 | 9.67 | 290 | 333317 | 59742 | 52955717 |
Urinary straining | 10.47 | 9.67 | 5 | 333602 | 33 | 53015426 |
Sepsis | 10.45 | 9.67 | 781 | 332826 | 145648 | 52869811 |
Pulmonary embolism | 10.45 | 9.67 | 597 | 333010 | 113845 | 52901614 |
Hypoacusis | 10.44 | 9.67 | 199 | 333408 | 22400 | 52993059 |
Scleritis | 10.43 | 9.67 | 4 | 333603 | 3366 | 53012093 |
Mandibular mass | 10.41 | 9.67 | 9 | 333598 | 181 | 53015278 |
Alpha hydroxybutyrate dehydrogenase increased | 10.40 | 9.67 | 4 | 333603 | 14 | 53015445 |
Eyelid retraction | 10.39 | 9.67 | 6 | 333601 | 61 | 53015398 |
Basal ganglia haemorrhage | 10.38 | 9.67 | 16 | 333591 | 613 | 53014846 |
Colitis microscopic | 10.38 | 9.67 | 78 | 333529 | 7016 | 53008443 |
Aortic valve replacement | 10.37 | 9.67 | 17 | 333590 | 687 | 53014772 |
Blood potassium increased | 10.37 | 9.67 | 163 | 333444 | 17678 | 52997781 |
Cataract operation | 10.37 | 9.67 | 54 | 333553 | 4274 | 53011185 |
Therapy partial responder | 10.36 | 9.67 | 14 | 333593 | 6149 | 53009310 |
Hyperthermia | 10.31 | 9.67 | 24 | 333583 | 8545 | 53006914 |
Alanine aminotransferase | 10.31 | 9.67 | 6 | 333601 | 62 | 53015397 |
Diarrhoea | 10.28 | 9.67 | 4197 | 329410 | 621349 | 52394110 |
Renal tubular necrosis | 10.28 | 9.67 | 113 | 333494 | 11306 | 53004153 |
Lymphadenopathy | 10.27 | 9.67 | 162 | 333445 | 36093 | 52979366 |
Feeling abnormal | 10.26 | 9.67 | 981 | 332626 | 134320 | 52881139 |
Vitrectomy | 10.23 | 9.67 | 8 | 333599 | 139 | 53015320 |
Dilatation atrial | 10.22 | 9.67 | 33 | 333574 | 2101 | 53013358 |
Paradoxical drug reaction | 10.20 | 9.67 | 4 | 333603 | 3321 | 53012138 |
Gastritis erosive | 10.19 | 9.67 | 65 | 333542 | 5541 | 53009918 |
Joint range of motion decreased | 10.18 | 9.67 | 68 | 333539 | 17888 | 52997571 |
Fructosamine increased | 10.18 | 9.67 | 3 | 333604 | 3 | 53015456 |
Autoimmune encephalopathy | 10.18 | 9.67 | 3 | 333604 | 3 | 53015456 |
Body temperature increased | 10.18 | 9.67 | 144 | 333463 | 32655 | 52982804 |
Left atrial dilatation | 10.17 | 9.67 | 31 | 333576 | 1914 | 53013545 |
Swelling face | 10.16 | 9.67 | 446 | 333161 | 56722 | 52958737 |
Hyperprolactinaemia | 10.15 | 9.67 | 4 | 333603 | 3311 | 53012148 |
Poverty of speech | 10.15 | 9.67 | 12 | 333595 | 355 | 53015104 |
Cystic fibrosis | 10.12 | 9.67 | 6 | 333601 | 3925 | 53011534 |
Blood calcium increased | 10.12 | 9.67 | 87 | 333520 | 8149 | 53007310 |
Laryngotracheal oedema | 10.11 | 9.67 | 5 | 333602 | 36 | 53015423 |
Tenderness | 10.08 | 9.67 | 77 | 333530 | 19653 | 52995806 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 10.06 | 9.67 | 35 | 333572 | 2316 | 53013143 |
Malignant polyp | 10.05 | 9.67 | 9 | 333598 | 190 | 53015269 |
Abdominal wall haemorrhage | 10.04 | 9.67 | 8 | 333599 | 143 | 53015316 |
Muscle rupture | 10.03 | 9.67 | 34 | 333573 | 2220 | 53013239 |
Retroperitoneal haematoma | 10.01 | 9.67 | 40 | 333567 | 2830 | 53012629 |
Product complaint | 10 | 9.67 | 119 | 333488 | 12138 | 53003321 |
Drug dependence | 9.96 | 9.67 | 86 | 333521 | 21386 | 52994073 |
Exposure via ingestion | 9.85 | 9.67 | 4 | 333603 | 3251 | 53012208 |
Intracranial haematoma | 9.83 | 9.67 | 12 | 333595 | 367 | 53015092 |
Arterial disorder | 9.78 | 9.67 | 22 | 333585 | 1129 | 53014330 |
Iron deficiency anaemia | 9.78 | 9.67 | 167 | 333440 | 18413 | 52997046 |
Atrial tachycardia | 9.77 | 9.67 | 34 | 333573 | 2250 | 53013209 |
Accelerated hypertension | 9.75 | 9.67 | 13 | 333594 | 435 | 53015024 |
C-reactive protein abnormal | 9.74 | 9.67 | 109 | 333498 | 25761 | 52989698 |
Paresis | 9.73 | 9.67 | 34 | 333573 | 2255 | 53013204 |
Aortic aneurysm | 9.73 | 9.67 | 46 | 333561 | 3502 | 53011957 |
Diabetes mellitus management | 9.73 | 9.67 | 3 | 333604 | 4 | 53015455 |
Interventricular septum rupture | 9.73 | 9.67 | 3 | 333604 | 4 | 53015455 |
Ocular icterus | 9.71 | 9.67 | 49 | 333558 | 3830 | 53011629 |
Erythema | 9.71 | 9.67 | 847 | 332760 | 156122 | 52859337 |
End stage renal disease | 9.69 | 9.67 | 69 | 333538 | 6102 | 53009357 |
Atrial thrombosis | 9.68 | 9.67 | 26 | 333581 | 1493 | 53013966 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myalgia | 1344.61 | 11.70 | 2730 | 331459 | 78500 | 32100837 |
Immune-mediated myositis | 1098.45 | 11.70 | 469 | 333720 | 1206 | 32178131 |
Rhabdomyolysis | 835.50 | 11.70 | 2016 | 332173 | 65249 | 32114088 |
Blood creatine phosphokinase increased | 500.27 | 11.70 | 1302 | 332887 | 44174 | 32135163 |
Drug abuse | 449.80 | 11.70 | 133 | 334056 | 80110 | 32099227 |
Toxicity to various agents | 425.41 | 11.70 | 736 | 333453 | 177305 | 32002032 |
Myopathy | 400.11 | 11.70 | 537 | 333652 | 10804 | 32168533 |
Febrile neutropenia | 363.32 | 11.70 | 416 | 333773 | 119150 | 32060187 |
Off label use | 362.52 | 11.70 | 1769 | 332420 | 304551 | 31874786 |
Foetal exposure during pregnancy | 346.73 | 11.70 | 19 | 334170 | 41282 | 32138055 |
Myocardial infarction | 328.33 | 11.70 | 2314 | 331875 | 123362 | 32055975 |
Necrotising myositis | 312.01 | 11.70 | 138 | 334051 | 398 | 32178939 |
Coronary artery disease | 248.12 | 11.70 | 1091 | 333098 | 48615 | 32130722 |
Drug ineffective | 236.01 | 11.70 | 2665 | 331524 | 380812 | 31798525 |
Neutropenia | 231.80 | 11.70 | 721 | 333468 | 141454 | 32037883 |
Pyrexia | 220.09 | 11.70 | 2166 | 332023 | 317802 | 31861535 |
Drug hypersensitivity | 204.74 | 11.70 | 1374 | 332815 | 72026 | 32107311 |
Completed suicide | 202.41 | 11.70 | 403 | 333786 | 92114 | 32087223 |
Cerebrovascular accident | 187.22 | 11.70 | 1522 | 332667 | 84798 | 32094539 |
Acute myocardial infarction | 177.66 | 11.70 | 1071 | 333118 | 54078 | 32125259 |
Angina pectoris | 172.42 | 11.70 | 710 | 333479 | 30716 | 32148621 |
Muscular weakness | 165.69 | 11.70 | 1231 | 332958 | 66698 | 32112639 |
Death | 160.04 | 11.70 | 2870 | 331319 | 379647 | 31799690 |
Blood cholesterol increased | 156.27 | 11.70 | 469 | 333720 | 17288 | 32162049 |
Chest pain | 149.47 | 11.70 | 1940 | 332249 | 122197 | 32057140 |
Acute kidney injury | 146.21 | 11.70 | 3998 | 330191 | 289470 | 31889867 |
Polymyositis | 145.37 | 11.70 | 122 | 334067 | 1384 | 32177953 |
Premature baby | 142.49 | 11.70 | 13 | 334176 | 18505 | 32160832 |
Dizziness | 138.54 | 11.70 | 2969 | 331220 | 206649 | 31972688 |
Low density lipoprotein increased | 137.60 | 11.70 | 193 | 333996 | 4053 | 32175284 |
Coronary artery stenosis | 120.77 | 11.70 | 293 | 333896 | 9500 | 32169837 |
High density lipoprotein decreased | 120.17 | 11.70 | 160 | 334029 | 3192 | 32176145 |
Drug resistance | 119.88 | 11.70 | 43 | 334146 | 22922 | 32156415 |
Mucosal inflammation | 119.06 | 11.70 | 101 | 334088 | 33333 | 32146004 |
Treatment failure | 117.98 | 11.70 | 137 | 334052 | 39026 | 32140311 |
Malignant neoplasm progression | 116.82 | 11.70 | 414 | 333775 | 78082 | 32101255 |
Muscle rupture | 116.25 | 11.70 | 129 | 334060 | 2113 | 32177224 |
Bone marrow failure | 114.33 | 11.70 | 87 | 334102 | 30317 | 32149020 |
Muscle spasms | 113.59 | 11.70 | 1165 | 333024 | 69253 | 32110084 |
Pneumonia | 108.86 | 11.70 | 2801 | 331388 | 352451 | 31826886 |
Coronary artery occlusion | 108.37 | 11.70 | 311 | 333878 | 11174 | 32168163 |
Transient ischaemic attack | 107.96 | 11.70 | 538 | 333651 | 25256 | 32154081 |
Cytomegalovirus infection | 107.65 | 11.70 | 64 | 334125 | 25400 | 32153937 |
Product use in unapproved indication | 104.71 | 11.70 | 500 | 333689 | 86704 | 32092633 |
Angina unstable | 103.72 | 11.70 | 321 | 333868 | 12034 | 32167303 |
Acute coronary syndrome | 102.37 | 11.70 | 346 | 333843 | 13595 | 32165742 |
White blood cell count decreased | 101.46 | 11.70 | 537 | 333652 | 90661 | 32088676 |
Ischaemic stroke | 99.48 | 11.70 | 401 | 333788 | 17175 | 32162162 |
Platelet count decreased | 98.91 | 11.70 | 730 | 333459 | 113861 | 32065476 |
Pancytopenia | 93.98 | 11.70 | 551 | 333638 | 90684 | 32088653 |
Sepsis | 90.54 | 11.70 | 1121 | 333068 | 157713 | 32021624 |
Leukopenia | 89.49 | 11.70 | 317 | 333872 | 59805 | 32119532 |
Graft versus host disease | 87.58 | 11.70 | 6 | 334183 | 10800 | 32168537 |
Neutrophil count decreased | 87.03 | 11.70 | 225 | 333964 | 46914 | 32132423 |
Drug interaction | 86.45 | 11.70 | 2891 | 331298 | 215294 | 31964043 |
Drug dependence | 82.32 | 11.70 | 72 | 334117 | 23412 | 32155925 |
Tendon rupture | 81.13 | 11.70 | 210 | 333979 | 7093 | 32172244 |
Suicide attempt | 79.00 | 11.70 | 172 | 334017 | 38072 | 32141265 |
Dyspnoea | 78.21 | 11.70 | 4505 | 329684 | 357540 | 31821797 |
Myositis | 77.40 | 11.70 | 273 | 333916 | 10962 | 32168375 |
Syncope | 75.47 | 11.70 | 1324 | 332865 | 88800 | 32090537 |
Stomatitis | 75.05 | 11.70 | 191 | 333998 | 40038 | 32139299 |
Overdose | 74.02 | 11.70 | 557 | 333632 | 86520 | 32092817 |
Pneumocystis jirovecii pneumonia | 73.53 | 11.70 | 52 | 334137 | 18818 | 32160519 |
Thrombocytopenia | 73.15 | 11.70 | 1078 | 333111 | 147221 | 32032116 |
Exposure during pregnancy | 72.31 | 11.70 | 6 | 334183 | 9223 | 32170114 |
Muscle disorder | 71.98 | 11.70 | 106 | 334083 | 2331 | 32177006 |
Autoimmune myositis | 71.84 | 11.70 | 29 | 334160 | 61 | 32179276 |
Mitral valve incompetence | 71.56 | 11.70 | 323 | 333866 | 14548 | 32164789 |
Low density lipoprotein decreased | 69.65 | 11.70 | 69 | 334120 | 984 | 32178353 |
Atrial fibrillation | 69.65 | 11.70 | 1630 | 332559 | 115074 | 32064263 |
Amnesia | 69.31 | 11.70 | 468 | 333721 | 24568 | 32154769 |
Blood triglycerides increased | 69.21 | 11.70 | 316 | 333873 | 14303 | 32165034 |
Vascular stent thrombosis | 67.03 | 11.70 | 105 | 334084 | 2442 | 32176895 |
Aspergillus infection | 66.99 | 11.70 | 18 | 334171 | 11556 | 32167781 |
Respiratory arrest | 66.58 | 11.70 | 122 | 334067 | 28786 | 32150551 |
Ascites | 65.94 | 11.70 | 203 | 333986 | 39988 | 32139349 |
Disseminated intravascular coagulation | 65.66 | 11.70 | 85 | 334104 | 23091 | 32156246 |
Product use issue | 65.45 | 11.70 | 299 | 333890 | 52478 | 32126859 |
Haematuria | 65.06 | 11.70 | 772 | 333417 | 47589 | 32131748 |
Bronchopulmonary aspergillosis | 64.34 | 11.70 | 30 | 334159 | 13657 | 32165680 |
Plasma cell myeloma | 64.18 | 11.70 | 339 | 333850 | 57275 | 32122062 |
Respiratory depression | 63.60 | 11.70 | 28 | 334161 | 13183 | 32166154 |
Type 2 diabetes mellitus | 63.16 | 11.70 | 316 | 333873 | 14856 | 32164481 |
Infusion related reaction | 62.91 | 11.70 | 248 | 333941 | 45351 | 32133986 |
Erectile dysfunction | 61.75 | 11.70 | 382 | 333807 | 19457 | 32159880 |
Disease progression | 61.49 | 11.70 | 583 | 333606 | 86279 | 32093058 |
Product substitution issue | 61.38 | 11.70 | 241 | 333948 | 10195 | 32169142 |
Muscle atrophy | 61.32 | 11.70 | 187 | 334002 | 6953 | 32172384 |
Immune reconstitution inflammatory syndrome | 61.03 | 11.70 | 12 | 334177 | 9547 | 32169790 |
Product monitoring error | 60.77 | 11.70 | 101 | 334088 | 2473 | 32176864 |
Rectal haemorrhage | 60.71 | 11.70 | 620 | 333569 | 36803 | 32142534 |
Pain in extremity | 58.66 | 11.70 | 1619 | 332570 | 117282 | 32062055 |
Pathogen resistance | 58.53 | 11.70 | 13 | 334176 | 9497 | 32169840 |
Myopathy toxic | 58.37 | 11.70 | 44 | 334145 | 422 | 32178915 |
Amyotrophic lateral sclerosis | 57.96 | 11.70 | 63 | 334126 | 1007 | 32178330 |
Hepatitis C | 57.10 | 11.70 | 34 | 334155 | 13484 | 32165853 |
Bradycardia | 56.25 | 11.70 | 1041 | 333148 | 70521 | 32108816 |
Septic shock | 55.94 | 11.70 | 447 | 333742 | 68542 | 32110795 |
Intentional self-injury | 55.90 | 11.70 | 37 | 334152 | 13863 | 32165474 |
Respiratory failure | 55.67 | 11.70 | 771 | 333418 | 106411 | 32072926 |
Hypomagnesaemia | 55.37 | 11.70 | 357 | 333832 | 18448 | 32160889 |
Melaena | 55.13 | 11.70 | 572 | 333617 | 34093 | 32145244 |
Asthenia | 54.70 | 11.70 | 2956 | 331233 | 232988 | 31946349 |
Intentional overdose | 53.80 | 11.70 | 232 | 333957 | 41369 | 32137968 |
Low birth weight baby | 53.57 | 11.70 | 5 | 334184 | 6989 | 32172348 |
Dyspnoea exertional | 53.30 | 11.70 | 624 | 333565 | 38337 | 32141000 |
Muscle injury | 52.86 | 11.70 | 65 | 334124 | 1194 | 32178143 |
Inferior vena cava dilatation | 52.57 | 11.70 | 50 | 334139 | 676 | 32178661 |
Infection | 52.40 | 11.70 | 587 | 333602 | 84128 | 32095209 |
Rheumatoid arthritis | 51.92 | 11.70 | 258 | 333931 | 44286 | 32135051 |
Upper gastrointestinal haemorrhage | 51.87 | 11.70 | 421 | 333768 | 23428 | 32155909 |
Chromaturia | 50.34 | 11.70 | 287 | 333902 | 14191 | 32165146 |
Poisoning | 50.11 | 11.70 | 26 | 334163 | 11132 | 32168205 |
Labelled drug-drug interaction medication error | 49.89 | 11.70 | 256 | 333933 | 12157 | 32167180 |
Myocardial ischaemia | 49.77 | 11.70 | 333 | 333856 | 17426 | 32161911 |
Intentional product misuse | 49.77 | 11.70 | 196 | 333993 | 35855 | 32143482 |
Muscle necrosis | 49.65 | 11.70 | 52 | 334137 | 795 | 32178542 |
Posterior reversible encephalopathy syndrome | 48.18 | 11.70 | 19 | 334170 | 9557 | 32169780 |
Multiple organ dysfunction syndrome | 48.09 | 11.70 | 472 | 333717 | 69382 | 32109955 |
Cytokine release syndrome | 48.04 | 11.70 | 41 | 334148 | 13494 | 32165843 |
Fall | 47.42 | 11.70 | 2468 | 331721 | 193733 | 31985604 |
Blood glucose increased | 47.15 | 11.70 | 937 | 333252 | 64304 | 32115033 |
Myelosuppression | 47.06 | 11.70 | 31 | 334158 | 11645 | 32167692 |
Presyncope | 46.45 | 11.70 | 321 | 333868 | 16980 | 32162357 |
Serotonin syndrome | 46.45 | 11.70 | 78 | 334111 | 19039 | 32160298 |
Myocardial necrosis marker increased | 45.98 | 11.70 | 69 | 334120 | 1544 | 32177793 |
Acute myeloid leukaemia | 45.88 | 11.70 | 79 | 334110 | 19095 | 32160242 |
Haemophagocytic lymphohistiocytosis | 45.82 | 11.70 | 30 | 334159 | 11305 | 32168032 |
Hypertensive emergency | 45.64 | 11.70 | 51 | 334138 | 842 | 32178495 |
Lactic acidosis | 45.38 | 11.70 | 536 | 333653 | 33000 | 32146337 |
Restlessness | 44.97 | 11.70 | 120 | 334069 | 24761 | 32154576 |
Ejection fraction decreased | 44.13 | 11.70 | 322 | 333867 | 17336 | 32162001 |
Seizure | 43.81 | 11.70 | 777 | 333412 | 103077 | 32076260 |
Cardiac failure | 43.71 | 11.70 | 1243 | 332946 | 90430 | 32088907 |
Glycosylated haemoglobin increased | 43.68 | 11.70 | 217 | 333972 | 10172 | 32169165 |
Therapeutic product effect incomplete | 43.43 | 11.70 | 248 | 333941 | 41093 | 32138244 |
Product prescribing error | 43.39 | 11.70 | 349 | 333840 | 19368 | 32159969 |
Hepatocellular carcinoma | 43.14 | 11.70 | 26 | 334163 | 10244 | 32169093 |
Neurotoxicity | 42.96 | 11.70 | 55 | 334134 | 15015 | 32164322 |
Ventricular hypokinesia | 42.70 | 11.70 | 129 | 334060 | 4771 | 32174566 |
Liver function test abnormal | 42.08 | 11.70 | 508 | 333681 | 31439 | 32147898 |
Diabetic ketoacidosis | 41.99 | 11.70 | 322 | 333867 | 17610 | 32161727 |
Oedema peripheral | 41.61 | 11.70 | 1498 | 332691 | 112593 | 32066744 |
Muscle enzyme increased | 41.55 | 11.70 | 28 | 334161 | 221 | 32179116 |
Cardiac disorder | 41.30 | 11.70 | 632 | 333557 | 41234 | 32138103 |
Intentional product use issue | 41.29 | 11.70 | 259 | 333930 | 41952 | 32137385 |
Epstein-Barr virus infection | 41.08 | 11.70 | 11 | 334178 | 7079 | 32172258 |
Hepatic encephalopathy | 40.79 | 11.70 | 56 | 334133 | 14839 | 32164498 |
Ischaemic cardiomyopathy | 40.64 | 11.70 | 152 | 334037 | 6282 | 32173055 |
C-reactive protein abnormal | 40.54 | 11.70 | 8 | 334181 | 6348 | 32172989 |
Faeces discoloured | 40.52 | 11.70 | 277 | 333912 | 14600 | 32164737 |
Low density lipoprotein abnormal | 40.51 | 11.70 | 29 | 334160 | 255 | 32179082 |
Progressive multifocal leukoencephalopathy | 40.22 | 11.70 | 24 | 334165 | 9507 | 32169830 |
Coma | 39.88 | 11.70 | 265 | 333924 | 42347 | 32136990 |
Tumour lysis syndrome | 39.53 | 11.70 | 55 | 334134 | 14492 | 32164845 |
Dermatomyositis | 38.96 | 11.70 | 55 | 334134 | 1162 | 32178175 |
Peritonitis | 38.63 | 11.70 | 110 | 334079 | 22220 | 32157117 |
Hypoglycaemia | 37.95 | 11.70 | 777 | 333412 | 53605 | 32125732 |
Post transplant lymphoproliferative disorder | 37.93 | 11.70 | 7 | 334182 | 5827 | 32173510 |
Hyperkalaemia | 37.89 | 11.70 | 962 | 333227 | 68788 | 32110549 |
Arteriosclerosis | 37.88 | 11.70 | 218 | 333971 | 10816 | 32168521 |
Blood cholesterol decreased | 37.27 | 11.70 | 49 | 334140 | 965 | 32178372 |
Agitation | 37.22 | 11.70 | 392 | 333797 | 56844 | 32122493 |
Glomerular filtration rate decreased | 36.97 | 11.70 | 242 | 333947 | 12569 | 32166768 |
Atrial septal defect | 36.92 | 11.70 | 13 | 334176 | 7012 | 32172325 |
Cardiac failure congestive | 36.77 | 11.70 | 1137 | 333052 | 83715 | 32095622 |
Carotid artery stenosis | 36.52 | 11.70 | 122 | 334067 | 4764 | 32174573 |
Exercise lack of | 36.34 | 11.70 | 20 | 334169 | 104 | 32179233 |
Cardiac failure chronic | 36.15 | 11.70 | 159 | 334030 | 7081 | 32172256 |
Bacteraemia | 35.83 | 11.70 | 80 | 334109 | 17553 | 32161784 |
Cystitis haemorrhagic | 35.80 | 11.70 | 5 | 334184 | 5109 | 32174228 |
Stent placement | 35.77 | 11.70 | 116 | 334073 | 4459 | 32174878 |
Pancreatitis acute | 35.71 | 11.70 | 434 | 333755 | 26901 | 32152436 |
Coronary artery bypass | 35.53 | 11.70 | 124 | 334065 | 4952 | 32174385 |
Hepatitis cholestatic | 35.43 | 11.70 | 173 | 334016 | 8052 | 32171285 |
Heart rate irregular | 35.34 | 11.70 | 257 | 333932 | 13821 | 32165516 |
Tendonitis | 34.30 | 11.70 | 179 | 334010 | 8556 | 32170781 |
Cardio-respiratory arrest | 34.19 | 11.70 | 389 | 333800 | 55600 | 32123737 |
Hepatocellular injury | 33.96 | 11.70 | 404 | 333785 | 24914 | 32154423 |
International normalised ratio increased | 33.68 | 11.70 | 699 | 333490 | 48336 | 32131001 |
Muscle fatigue | 33.42 | 11.70 | 52 | 334137 | 1202 | 32178135 |
Vascular stent stenosis | 33.32 | 11.70 | 48 | 334141 | 1034 | 32178303 |
Drug withdrawal syndrome | 33.31 | 11.70 | 102 | 334087 | 20129 | 32159208 |
Neoplasm progression | 33.16 | 11.70 | 98 | 334091 | 19560 | 32159777 |
Myelodysplastic syndrome | 33.01 | 11.70 | 101 | 334088 | 19937 | 32159400 |
Maternal drugs affecting foetus | 32.91 | 11.70 | 3 | 334186 | 4274 | 32175063 |
Balance disorder | 32.03 | 11.70 | 577 | 333612 | 38882 | 32140455 |
Neuroleptic malignant syndrome | 31.90 | 11.70 | 84 | 334105 | 17411 | 32161926 |
Haematochezia | 31.71 | 11.70 | 573 | 333616 | 38635 | 32140702 |
Neonatal respiratory distress syndrome | 31.67 | 11.70 | 3 | 334186 | 4144 | 32175193 |
Abnormal behaviour | 31.58 | 11.70 | 152 | 334037 | 26314 | 32153023 |
Diabetes mellitus inadequate control | 31.55 | 11.70 | 246 | 333943 | 13522 | 32165815 |
Haematoma | 31.50 | 11.70 | 403 | 333786 | 25281 | 32154056 |
Diabetic nephropathy | 31.47 | 11.70 | 69 | 334120 | 2090 | 32177247 |
Orthostatic hypotension | 31.26 | 11.70 | 402 | 333787 | 25248 | 32154089 |
Akathisia | 30.62 | 11.70 | 17 | 334172 | 7008 | 32172329 |
Polymyalgia rheumatica | 30.59 | 11.70 | 51 | 334138 | 1252 | 32178085 |
Vomiting | 30.57 | 11.70 | 2048 | 332141 | 233509 | 31945828 |
Febrile bone marrow aplasia | 30.47 | 11.70 | 25 | 334164 | 8390 | 32170947 |
Arteriosclerosis coronary artery | 30.46 | 11.70 | 218 | 333971 | 11663 | 32167674 |
Hyperlipidaemia | 30.39 | 11.70 | 254 | 333935 | 14257 | 32165080 |
Hypercholesterolaemia | 30.35 | 11.70 | 162 | 334027 | 7812 | 32171525 |
Tricuspid valve incompetence | 30.28 | 11.70 | 181 | 334008 | 9106 | 32170231 |
Substance abuse | 29.84 | 11.70 | 18 | 334171 | 7089 | 32172248 |
Blood creatine phosphokinase MB increased | 29.75 | 11.70 | 64 | 334125 | 1913 | 32177424 |
Cytomegalovirus viraemia | 29.73 | 11.70 | 16 | 334173 | 6711 | 32172626 |
Gastrointestinal haemorrhage | 29.54 | 11.70 | 1132 | 333057 | 85750 | 32093587 |
Exercise tolerance decreased | 29.49 | 11.70 | 109 | 334080 | 4479 | 32174858 |
Troponin increased | 29.42 | 11.70 | 189 | 334000 | 9753 | 32169584 |
Intermittent claudication | 29.39 | 11.70 | 70 | 334119 | 2242 | 32177095 |
Blood cholesterol | 29.16 | 11.70 | 20 | 334169 | 163 | 32179174 |
Blood cholesterol abnormal | 29.16 | 11.70 | 54 | 334135 | 1444 | 32177893 |
Lymphocyte count decreased | 29.03 | 11.70 | 115 | 334074 | 21004 | 32158333 |
Coronary artery restenosis | 28.77 | 11.70 | 47 | 334142 | 1134 | 32178203 |
Myoglobin blood increased | 28.74 | 11.70 | 61 | 334128 | 1806 | 32177531 |
Swollen tongue | 28.70 | 11.70 | 239 | 333950 | 13400 | 32165937 |
Enterococcal infection | 28.63 | 11.70 | 31 | 334158 | 9116 | 32170221 |
Depressed level of consciousness | 28.52 | 11.70 | 275 | 333914 | 40572 | 32138765 |
Palpitations | 28.50 | 11.70 | 524 | 333665 | 35445 | 32143892 |
Blood loss anaemia | 28.45 | 11.70 | 159 | 334030 | 7803 | 32171534 |
Aggression | 28.44 | 11.70 | 263 | 333926 | 39126 | 32140211 |
Cerebral haemorrhage | 28.17 | 11.70 | 508 | 333681 | 34239 | 32145098 |
Glycogen storage disease type V | 27.79 | 11.70 | 12 | 334177 | 32 | 32179305 |
Genital swelling | 27.74 | 11.70 | 20 | 334169 | 178 | 32179159 |
Nocturia | 27.70 | 11.70 | 177 | 334012 | 9117 | 32170220 |
Type IIa hyperlipidaemia | 27.48 | 11.70 | 21 | 334168 | 206 | 32179131 |
Acute respiratory distress syndrome | 27.33 | 11.70 | 150 | 334039 | 25103 | 32154234 |
Haematotoxicity | 27.30 | 11.70 | 18 | 334171 | 6758 | 32172579 |
Hypoalbuminaemia | 27.12 | 11.70 | 50 | 334139 | 11772 | 32167565 |
Psychotic disorder | 27.01 | 11.70 | 133 | 334056 | 22887 | 32156450 |
Condition aggravated | 26.96 | 11.70 | 1316 | 332873 | 154345 | 32024992 |
Stenosis | 26.93 | 11.70 | 43 | 334146 | 1017 | 32178320 |
Maternal exposure during pregnancy | 26.73 | 11.70 | 6 | 334183 | 4351 | 32174986 |
Drug use disorder | 26.67 | 11.70 | 3 | 334186 | 3618 | 32175719 |
Status epilepticus | 26.47 | 11.70 | 52 | 334137 | 11954 | 32167383 |
Pseudomonas infection | 25.91 | 11.70 | 53 | 334136 | 12003 | 32167334 |
Ocular myasthenia | 25.83 | 11.70 | 21 | 334168 | 227 | 32179110 |
Haemorrhagic stroke | 25.61 | 11.70 | 133 | 334056 | 6345 | 32172992 |
Carotid artery occlusion | 25.37 | 11.70 | 63 | 334126 | 2073 | 32177264 |
Pruritus genital | 25.27 | 11.70 | 31 | 334158 | 568 | 32178769 |
Hepatitis B reactivation | 25.04 | 11.70 | 3 | 334186 | 3446 | 32175891 |
Musculoskeletal pain | 25.04 | 11.70 | 464 | 333725 | 31433 | 32147904 |
Blood urea abnormal | 24.80 | 11.70 | 36 | 334153 | 781 | 32178556 |
Toxic epidermal necrolysis | 24.73 | 11.70 | 118 | 334071 | 20475 | 32158862 |
Candida infection | 24.72 | 11.70 | 89 | 334100 | 16714 | 32162623 |
Ileus | 24.69 | 11.70 | 85 | 334104 | 16180 | 32163157 |
Ventricular enlargement | 24.53 | 11.70 | 27 | 334162 | 438 | 32178899 |
Cytopenia | 24.51 | 11.70 | 41 | 334148 | 10023 | 32169314 |
Hepatic enzyme increased | 24.47 | 11.70 | 525 | 333664 | 36512 | 32142825 |
Drug ineffective for unapproved indication | 24.46 | 11.70 | 68 | 334121 | 13844 | 32165493 |
Lipids abnormal | 24.35 | 11.70 | 24 | 334165 | 340 | 32178997 |
Quadriparesis | 24.33 | 11.70 | 45 | 334144 | 1202 | 32178135 |
N-terminal prohormone brain natriuretic peptide increased | 24.21 | 11.70 | 60 | 334129 | 1972 | 32177365 |
Encephalopathy | 24.18 | 11.70 | 230 | 333959 | 34027 | 32145310 |
Hyperammonaemia | 23.85 | 11.70 | 16 | 334173 | 5953 | 32173384 |
Hypotension | 23.51 | 11.70 | 2551 | 331638 | 213559 | 31965778 |
Acquired claw toe | 23.24 | 11.70 | 8 | 334181 | 8 | 32179329 |
Transplant rejection | 23.20 | 11.70 | 42 | 334147 | 9957 | 32169380 |
Device related infection | 23.18 | 11.70 | 100 | 334089 | 17833 | 32161504 |
Computerised tomogram coronary artery abnormal | 23.07 | 11.70 | 17 | 334172 | 157 | 32179180 |
Respiratory distress | 23.06 | 11.70 | 241 | 333948 | 35005 | 32144332 |
Pericardial haemorrhage | 23.01 | 11.70 | 77 | 334112 | 3009 | 32176328 |
Electrocardiogram ST segment depression | 22.93 | 11.70 | 66 | 334123 | 2375 | 32176962 |
Therapy partial responder | 22.87 | 11.70 | 11 | 334178 | 4919 | 32174418 |
Haemorrhage intracranial | 22.86 | 11.70 | 257 | 333932 | 15630 | 32163707 |
Hyperbilirubinaemia | 22.84 | 11.70 | 99 | 334090 | 17631 | 32161706 |
Muscle discomfort | 22.80 | 11.70 | 11 | 334178 | 41 | 32179296 |
Muscle strain | 22.78 | 11.70 | 89 | 334100 | 3756 | 32175581 |
Lip swelling | 22.77 | 11.70 | 229 | 333960 | 13536 | 32165801 |
Essential hypertension | 22.64 | 11.70 | 70 | 334119 | 2622 | 32176715 |
Tachycardia | 22.63 | 11.70 | 629 | 333560 | 78459 | 32100878 |
Osteonecrosis | 22.54 | 11.70 | 91 | 334098 | 16531 | 32162806 |
Pneumatosis intestinalis | 22.46 | 11.70 | 4 | 334185 | 3416 | 32175921 |
Cardiac aneurysm | 22.20 | 11.70 | 37 | 334152 | 908 | 32178429 |
Shock | 22.04 | 11.70 | 151 | 334038 | 23963 | 32155374 |
Pelvic mass | 22.04 | 11.70 | 18 | 334171 | 196 | 32179141 |
Eye injury | 21.96 | 11.70 | 31 | 334158 | 655 | 32178682 |
Epilepsy | 21.96 | 11.70 | 135 | 334054 | 21974 | 32157363 |
Potassium wasting nephropathy | 21.90 | 11.70 | 14 | 334175 | 100 | 32179237 |
Degenerative mitral valve disease | 21.78 | 11.70 | 19 | 334170 | 228 | 32179109 |
Abnormal weight gain | 21.77 | 11.70 | 37 | 334152 | 923 | 32178414 |
Osteonecrosis of jaw | 21.76 | 11.70 | 112 | 334077 | 19054 | 32160283 |
Dystonia | 21.74 | 11.70 | 48 | 334141 | 10575 | 32168762 |
Carotid artery disease | 21.66 | 11.70 | 37 | 334152 | 927 | 32178410 |
Mixed liver injury | 21.62 | 11.70 | 67 | 334122 | 2513 | 32176824 |
Abdominal pain | 21.62 | 11.70 | 1287 | 332902 | 148242 | 32031095 |
Thrombocytopenic purpura | 21.60 | 11.70 | 42 | 334147 | 1166 | 32178171 |
Sinusitis | 21.54 | 11.70 | 256 | 333933 | 36304 | 32143033 |
Ventricular septal defect | 21.45 | 11.70 | 6 | 334183 | 3751 | 32175586 |
Arterial stenosis | 21.44 | 11.70 | 43 | 334146 | 1222 | 32178115 |
Nocardiosis | 21.22 | 11.70 | 6 | 334183 | 3725 | 32175612 |
Oropharyngeal pain | 21.08 | 11.70 | 213 | 333976 | 31139 | 32148198 |
Atrial enlargement | 21.00 | 11.70 | 21 | 334168 | 303 | 32179034 |
Palmar-plantar erythrodysaesthesia syndrome | 20.86 | 11.70 | 87 | 334102 | 15662 | 32163675 |
Clostridium difficile infection | 20.77 | 11.70 | 103 | 334086 | 17693 | 32161644 |
Asthma | 20.75 | 11.70 | 323 | 333866 | 43742 | 32135595 |
Vertigo | 20.74 | 11.70 | 358 | 333831 | 23925 | 32155412 |
Product odour abnormal | 20.68 | 11.70 | 31 | 334158 | 693 | 32178644 |
Pneumonia aspiration | 20.65 | 11.70 | 298 | 333891 | 40858 | 32138479 |
Pneumonia cytomegaloviral | 20.59 | 11.70 | 3 | 334186 | 2969 | 32176368 |
Oxygen saturation decreased | 20.54 | 11.70 | 359 | 333830 | 47740 | 32131597 |
Penile haemorrhage | 20.50 | 11.70 | 29 | 334160 | 614 | 32178723 |
Dyskinesia | 20.50 | 11.70 | 150 | 334039 | 23453 | 32155884 |
Plantar fasciitis | 20.43 | 11.70 | 37 | 334152 | 972 | 32178365 |
Radiculitis brachial | 20.41 | 11.70 | 8 | 334181 | 15 | 32179322 |
Apparent death | 20.22 | 11.70 | 6 | 334183 | 3609 | 32175728 |
Cardiac failure acute | 20.14 | 11.70 | 176 | 334013 | 10008 | 32169329 |
Normocytic anaemia | 20.12 | 11.70 | 58 | 334131 | 2089 | 32177248 |
Dyspnoea at rest | 20.10 | 11.70 | 78 | 334111 | 3281 | 32176056 |
Mycobacterium avium complex infection | 20.08 | 11.70 | 3 | 334186 | 2914 | 32176423 |
Cerebral infarction | 20.07 | 11.70 | 397 | 333792 | 27217 | 32152120 |
Shock haemorrhagic | 20.04 | 11.70 | 182 | 334007 | 10463 | 32168874 |
Peripheral vascular disorder | 19.99 | 11.70 | 107 | 334082 | 5165 | 32174172 |
Colitis | 19.90 | 11.70 | 238 | 333951 | 33713 | 32145624 |
Cerebral haematoma | 19.88 | 11.70 | 100 | 334089 | 4711 | 32174626 |
Lipids increased | 19.79 | 11.70 | 36 | 334153 | 949 | 32178388 |
Fungal infection | 19.76 | 11.70 | 85 | 334104 | 15170 | 32164167 |
Brain oedema | 19.49 | 11.70 | 68 | 334121 | 12892 | 32166445 |
Altered state of consciousness | 19.49 | 11.70 | 139 | 334050 | 21858 | 32157479 |
Hepatojugular reflux | 19.47 | 11.70 | 22 | 334167 | 368 | 32178969 |
Transient global amnesia | 19.35 | 11.70 | 21 | 334168 | 335 | 32179002 |
Obstructive pancreatitis | 19.26 | 11.70 | 24 | 334165 | 447 | 32178890 |
Diffuse large B-cell lymphoma | 19.22 | 11.70 | 36 | 334153 | 8426 | 32170911 |
Myasthenia gravis | 19.20 | 11.70 | 81 | 334108 | 3541 | 32175796 |
Vitreous detachment | 19.20 | 11.70 | 33 | 334156 | 831 | 32178506 |
Lymphadenopathy | 19.04 | 11.70 | 182 | 334007 | 26900 | 32152437 |
Acquired haemophilia | 18.97 | 11.70 | 34 | 334155 | 886 | 32178451 |
Cytomegalovirus test positive | 18.88 | 11.70 | 8 | 334181 | 3854 | 32175483 |
Cardiotoxicity | 18.68 | 11.70 | 14 | 334175 | 4918 | 32174419 |
Hypocalcaemia | 18.66 | 11.70 | 337 | 333852 | 22717 | 32156620 |
Penis injury | 18.66 | 11.70 | 18 | 334171 | 248 | 32179089 |
Somnolence | 18.65 | 11.70 | 874 | 333315 | 102923 | 32076414 |
Appendicitis | 18.61 | 11.70 | 40 | 334149 | 8897 | 32170440 |
Lymph node calcification | 18.59 | 11.70 | 17 | 334172 | 218 | 32179119 |
Oscillopsia | 18.57 | 11.70 | 9 | 334180 | 34 | 32179303 |
Atrial flutter | 18.51 | 11.70 | 238 | 333951 | 14945 | 32164392 |
Venoocclusive disease | 18.50 | 11.70 | 3 | 334186 | 2743 | 32176594 |
Memory impairment | 18.48 | 11.70 | 546 | 333643 | 39933 | 32139404 |
Thrombotic microangiopathy | 18.47 | 11.70 | 44 | 334145 | 9438 | 32169899 |
Hepatic failure | 18.37 | 11.70 | 257 | 333932 | 35423 | 32143914 |
Non-cardiac chest pain | 18.35 | 11.70 | 91 | 334098 | 4262 | 32175075 |
Aortic aneurysm | 18.23 | 11.70 | 125 | 334064 | 6594 | 32172743 |
Disease recurrence | 18.17 | 11.70 | 94 | 334095 | 15970 | 32163367 |
Peripheral ischaemia | 18.15 | 11.70 | 112 | 334077 | 5699 | 32173638 |
Enthesopathy | 18.04 | 11.70 | 7 | 334182 | 3556 | 32175781 |
Staphylococcal infection | 18.03 | 11.70 | 230 | 333959 | 32209 | 32147128 |
Pulmonary vascular disorder | 18.03 | 11.70 | 27 | 334162 | 603 | 32178734 |
Peripheral paralysis | 17.99 | 11.70 | 9 | 334180 | 37 | 32179300 |
Arterial occlusive disease | 17.96 | 11.70 | 90 | 334099 | 4233 | 32175104 |
Pneumonia fungal | 17.82 | 11.70 | 23 | 334166 | 6257 | 32173080 |
Hepatitis acute | 17.82 | 11.70 | 133 | 334056 | 7212 | 32172125 |
Diabetes mellitus | 17.65 | 11.70 | 598 | 333591 | 44575 | 32134762 |
Fibrous histiocytoma | 17.65 | 11.70 | 13 | 334176 | 120 | 32179217 |
Hypercalcaemia | 17.64 | 11.70 | 78 | 334111 | 13816 | 32165521 |
On and off phenomenon | 17.53 | 11.70 | 7 | 334182 | 3494 | 32175843 |
Pulmonary valve incompetence | 17.47 | 11.70 | 30 | 334159 | 755 | 32178582 |
Sedation | 17.43 | 11.70 | 115 | 334074 | 18411 | 32160926 |
Occupational problem environmental | 17.43 | 11.70 | 6 | 334183 | 6 | 32179331 |
Avoidant personality disorder | 17.43 | 11.70 | 6 | 334183 | 6 | 32179331 |
Klebsiella infection | 17.41 | 11.70 | 35 | 334154 | 7977 | 32171360 |
Herbal interaction | 17.40 | 11.70 | 20 | 334169 | 341 | 32178996 |
Accidental exposure to product | 17.37 | 11.70 | 58 | 334131 | 11144 | 32168193 |
Ageusia | 17.32 | 11.70 | 164 | 334025 | 9538 | 32169799 |
Miosis | 17.27 | 11.70 | 40 | 334149 | 8664 | 32170673 |
Cardiac valve disease | 17.25 | 11.70 | 71 | 334118 | 3069 | 32176268 |
Blood triglycerides decreased | 17.17 | 11.70 | 10 | 334179 | 59 | 32179278 |
Foetal growth restriction | 17.07 | 11.70 | 10 | 334179 | 4002 | 32175335 |
Paraesthesia | 17.05 | 11.70 | 755 | 333434 | 58189 | 32121148 |
Neutropenic colitis | 17.03 | 11.70 | 3 | 334186 | 2582 | 32176755 |
Drug abuser | 17.01 | 11.70 | 11 | 334178 | 4173 | 32175164 |
Left atrial dilatation | 16.99 | 11.70 | 50 | 334139 | 1822 | 32177515 |
Product administered to patient of inappropriate age | 16.94 | 11.70 | 4 | 334185 | 2802 | 32176535 |
Systemic candida | 16.92 | 11.70 | 5 | 334184 | 3016 | 32176321 |
Crohn's disease | 16.89 | 11.70 | 12 | 334177 | 4333 | 32175004 |
Blood immunoglobulin E increased | 16.85 | 11.70 | 53 | 334136 | 2004 | 32177333 |
Nicotine dependence | 16.76 | 11.70 | 24 | 334165 | 514 | 32178823 |
Pulmonary haemorrhage | 16.73 | 11.70 | 49 | 334140 | 9808 | 32169529 |
Gynaecomastia | 16.71 | 11.70 | 151 | 334038 | 8668 | 32170669 |
Withdrawal syndrome | 16.66 | 11.70 | 66 | 334123 | 12056 | 32167281 |
Nephropathy toxic | 16.45 | 11.70 | 65 | 334124 | 11881 | 32167456 |
Gout | 16.32 | 11.70 | 277 | 333912 | 18451 | 32160886 |
Pruritus | 16.24 | 11.70 | 1535 | 332654 | 127167 | 32052170 |
Impatience | 16.21 | 11.70 | 18 | 334171 | 295 | 32179042 |
Generalised tonic-clonic seizure | 16.13 | 11.70 | 135 | 334054 | 20504 | 32158833 |
Benign pancreatic neoplasm | 16.12 | 11.70 | 6 | 334183 | 9 | 32179328 |
Angiocardiogram | 16.12 | 11.70 | 15 | 334174 | 197 | 32179140 |
Type V hyperlipidaemia | 16.04 | 11.70 | 28 | 334161 | 714 | 32178623 |
Lipoprotein (a) increased | 16.03 | 11.70 | 9 | 334180 | 49 | 32179288 |
Psychomotor hyperactivity | 16.03 | 11.70 | 44 | 334145 | 8995 | 32170342 |
Hypertransaminasaemia | 16.02 | 11.70 | 85 | 334104 | 4089 | 32175248 |
Autoimmune disorder | 15.92 | 11.70 | 45 | 334144 | 1602 | 32177735 |
Lipodystrophy acquired | 15.92 | 11.70 | 9 | 334180 | 3673 | 32175664 |
Aortic stenosis | 15.86 | 11.70 | 86 | 334103 | 4172 | 32175165 |
Paradoxical drug reaction | 15.85 | 11.70 | 5 | 334184 | 2891 | 32176446 |
Tuberculosis | 15.85 | 11.70 | 42 | 334147 | 8687 | 32170650 |
Bacterial infection | 15.82 | 11.70 | 82 | 334107 | 13924 | 32165413 |
Vascular graft | 15.81 | 11.70 | 42 | 334147 | 1441 | 32177896 |
Chest discomfort | 15.79 | 11.70 | 649 | 333540 | 49581 | 32129756 |
Autoimmune myocarditis | 15.72 | 11.70 | 14 | 334175 | 173 | 32179164 |
Subarachnoid haemorrhage | 15.71 | 11.70 | 170 | 334019 | 10241 | 32169096 |
Suicidal ideation | 15.70 | 11.70 | 286 | 333903 | 37797 | 32141540 |
Delirium | 15.68 | 11.70 | 339 | 333850 | 43707 | 32135630 |
Spinal stenosis | 15.65 | 11.70 | 90 | 334099 | 4464 | 32174873 |
Anticoagulation drug level increased | 15.61 | 11.70 | 23 | 334166 | 506 | 32178831 |
Staphylococcal sepsis | 15.60 | 11.70 | 51 | 334138 | 9862 | 32169475 |
Bilirubin conjugated abnormal | 15.60 | 11.70 | 12 | 334177 | 119 | 32179218 |
Aortic valve replacement | 15.48 | 11.70 | 28 | 334161 | 735 | 32178602 |
Iliac artery stenosis | 15.43 | 11.70 | 11 | 334178 | 96 | 32179241 |
Liver transplant | 15.37 | 11.70 | 5 | 334184 | 2835 | 32176502 |
Diffuse large B-cell lymphoma recurrent | 15.32 | 11.70 | 4 | 334185 | 2618 | 32176719 |
Adrenal insufficiency | 15.31 | 11.70 | 67 | 334122 | 11901 | 32167436 |
Hepatitis B | 15.28 | 11.70 | 26 | 334163 | 6315 | 32173022 |
Clonus | 15.25 | 11.70 | 4 | 334185 | 2610 | 32176727 |
C-reactive protein increased | 15.22 | 11.70 | 377 | 333812 | 47725 | 32131612 |
Epicondylitis | 15.18 | 11.70 | 21 | 334168 | 435 | 32178902 |
Hepatic vein dilatation | 15.08 | 11.70 | 15 | 334174 | 215 | 32179122 |
Post micturition dribble | 15.06 | 11.70 | 6 | 334183 | 12 | 32179325 |
Cystic fibrosis | 15.04 | 11.70 | 3 | 334186 | 2363 | 32176974 |
Mydriasis | 15.02 | 11.70 | 27 | 334162 | 6419 | 32172918 |
Cytomegalovirus infection reactivation | 14.99 | 11.70 | 8 | 334181 | 3371 | 32175966 |
Ventricular dyskinesia | 14.97 | 11.70 | 14 | 334175 | 185 | 32179152 |
Drug level increased | 14.96 | 11.70 | 133 | 334056 | 19947 | 32159390 |
Rhinovirus infection | 14.94 | 11.70 | 8 | 334181 | 3365 | 32175972 |
Mastitis | 14.86 | 11.70 | 14 | 334175 | 187 | 32179150 |
Portal hypertension | 14.81 | 11.70 | 12 | 334177 | 4052 | 32175285 |
Bundle branch block left | 14.79 | 11.70 | 106 | 334083 | 5673 | 32173664 |
Violence-related symptom | 14.71 | 11.70 | 23 | 334166 | 534 | 32178803 |
Cholestasis | 14.71 | 11.70 | 373 | 333816 | 26660 | 32152677 |
Acute lymphocytic leukaemia | 14.64 | 11.70 | 9 | 334180 | 3509 | 32175828 |
Gastrointestinal angiodysplasia | 14.59 | 11.70 | 25 | 334164 | 628 | 32178709 |
Deep vein thrombosis | 14.52 | 11.70 | 522 | 333667 | 63191 | 32116146 |
Second primary malignancy | 14.51 | 11.70 | 31 | 334158 | 6910 | 32172427 |
Blood creatine phosphokinase abnormal | 14.49 | 11.70 | 15 | 334174 | 226 | 32179111 |
Pollakiuria | 14.48 | 11.70 | 272 | 333917 | 18472 | 32160865 |
Aldolase increased | 14.46 | 11.70 | 9 | 334180 | 61 | 32179276 |
Aortic arteriosclerosis | 14.43 | 11.70 | 81 | 334108 | 3981 | 32175356 |
Blood glucose decreased | 14.39 | 11.70 | 207 | 333982 | 13327 | 32166010 |
Hepatitis A virus test positive | 14.35 | 11.70 | 4 | 334185 | 0 | 32179337 |
Immunology test abnormal | 14.35 | 11.70 | 4 | 334185 | 0 | 32179337 |
Arterial repair | 14.35 | 11.70 | 4 | 334185 | 0 | 32179337 |
Cells in urine | 14.35 | 11.70 | 4 | 334185 | 0 | 32179337 |
Sopor | 14.30 | 11.70 | 67 | 334122 | 11682 | 32167655 |
Scrotal pain | 14.30 | 11.70 | 30 | 334159 | 881 | 32178456 |
Hypogammaglobulinaemia | 14.27 | 11.70 | 26 | 334163 | 6150 | 32173187 |
Herpes zoster | 14.25 | 11.70 | 240 | 333949 | 32101 | 32147236 |
Eructation | 14.25 | 11.70 | 80 | 334109 | 3933 | 32175404 |
Helicobacter test positive | 14.22 | 11.70 | 27 | 334162 | 736 | 32178601 |
Therapy non-responder | 14.17 | 11.70 | 243 | 333946 | 32411 | 32146926 |
AST/ALT ratio abnormal | 14.17 | 11.70 | 6 | 334183 | 15 | 32179322 |
Skin toxicity | 14.17 | 11.70 | 11 | 334178 | 3795 | 32175542 |
Electrocardiogram ST-T change | 14.14 | 11.70 | 24 | 334165 | 598 | 32178739 |
Brain natriuretic peptide increased | 14.14 | 11.70 | 84 | 334105 | 4216 | 32175121 |
Congenital diaphragmatic anomaly | 14.14 | 11.70 | 7 | 334182 | 28 | 32179309 |
Blood creatine increased | 14.10 | 11.70 | 92 | 334097 | 4773 | 32174564 |
Metastases to central nervous system | 14.06 | 11.70 | 37 | 334152 | 7671 | 32171666 |
Therapeutic product effect decreased | 14.05 | 11.70 | 229 | 333960 | 30788 | 32148549 |
Toe amputation | 14.05 | 11.70 | 55 | 334134 | 2323 | 32177014 |
Hepatic cirrhosis | 14.04 | 11.70 | 108 | 334081 | 16701 | 32162636 |
Atrioventricular block second degree | 13.96 | 11.70 | 71 | 334118 | 3359 | 32175978 |
Hemianaesthesia | 13.96 | 11.70 | 10 | 334179 | 88 | 32179249 |
Lacunar stroke | 13.96 | 11.70 | 12 | 334177 | 141 | 32179196 |
Therapeutic response decreased | 13.96 | 11.70 | 185 | 334004 | 25735 | 32153602 |
ECG signs of myocardial ischaemia | 13.95 | 11.70 | 14 | 334175 | 203 | 32179134 |
Haematoma muscle | 13.94 | 11.70 | 32 | 334157 | 1000 | 32178337 |
Ventricular hypertrophy | 13.91 | 11.70 | 93 | 334096 | 4865 | 32174472 |
Wound haematoma | 13.89 | 11.70 | 9 | 334180 | 66 | 32179271 |
Liver palpable | 13.82 | 11.70 | 16 | 334173 | 275 | 32179062 |
Microcytic anaemia | 13.80 | 11.70 | 52 | 334137 | 2157 | 32177180 |
Blood pressure inadequately controlled | 13.76 | 11.70 | 60 | 334129 | 2662 | 32176675 |
Right ventricular enlargement | 13.73 | 11.70 | 14 | 334175 | 207 | 32179130 |
Nipple pain | 13.70 | 11.70 | 24 | 334165 | 614 | 32178723 |
Drug screen positive | 13.69 | 11.70 | 14 | 334175 | 4227 | 32175110 |
Primary biliary cholangitis | 13.69 | 11.70 | 12 | 334177 | 145 | 32179192 |
Systolic dysfunction | 13.69 | 11.70 | 53 | 334136 | 2227 | 32177110 |
Peripheral artery occlusion | 13.67 | 11.70 | 42 | 334147 | 1568 | 32177769 |
Weight decreased | 13.65 | 11.70 | 1913 | 332276 | 162905 | 32016432 |
Herpes simplex | 13.62 | 11.70 | 20 | 334169 | 5154 | 32174183 |
Dilatation atrial | 13.60 | 11.70 | 51 | 334138 | 2110 | 32177227 |
Angioedema | 13.58 | 11.70 | 478 | 333711 | 35811 | 32143526 |
Clostridium difficile colitis | 13.46 | 11.70 | 89 | 334100 | 14242 | 32165095 |
Cardiac stress test abnormal | 13.45 | 11.70 | 18 | 334171 | 361 | 32178976 |
Neutropenic sepsis | 13.43 | 11.70 | 76 | 334113 | 12623 | 32166714 |
Sinus bradycardia | 13.41 | 11.70 | 197 | 333992 | 12741 | 32166596 |
Gamma-glutamyltransferase abnormal | 13.41 | 11.70 | 15 | 334174 | 248 | 32179089 |
Anal abscess | 13.40 | 11.70 | 23 | 334166 | 5567 | 32173770 |
Conjunctival hyperaemia | 13.38 | 11.70 | 4 | 334185 | 2394 | 32176943 |
Chronic kidney disease | 13.37 | 11.70 | 520 | 333669 | 39455 | 32139882 |
Neuromyopathy | 13.34 | 11.70 | 31 | 334158 | 977 | 32178360 |
Peripheral coldness | 13.32 | 11.70 | 118 | 334071 | 6735 | 32172602 |
Dyspnoea paroxysmal nocturnal | 13.28 | 11.70 | 40 | 334149 | 1477 | 32177860 |
Cardiac ablation | 13.27 | 11.70 | 24 | 334165 | 630 | 32178707 |
Synovitis | 13.25 | 11.70 | 62 | 334127 | 10816 | 32168521 |
Device issue | 13.24 | 11.70 | 47 | 334142 | 8865 | 32170472 |
Hypernatraemia | 13.20 | 11.70 | 42 | 334147 | 8191 | 32171146 |
Central obesity | 13.20 | 11.70 | 22 | 334167 | 540 | 32178797 |
Urticaria chronic | 13.18 | 11.70 | 10 | 334179 | 97 | 32179240 |
Peripheral artery stenosis | 13.13 | 11.70 | 29 | 334160 | 883 | 32178454 |
Product contamination physical | 13.09 | 11.70 | 7 | 334182 | 34 | 32179303 |
Discoloured vomit | 13.08 | 11.70 | 21 | 334168 | 499 | 32178838 |
Alcohol abuse | 13.08 | 11.70 | 16 | 334173 | 4456 | 32174881 |
Peripheral arterial occlusive disease | 13.08 | 11.70 | 102 | 334087 | 5607 | 32173730 |
Hypoxia | 13.07 | 11.70 | 422 | 333767 | 51710 | 32127627 |
Ammonia increased | 13.03 | 11.70 | 16 | 334173 | 4448 | 32174889 |
Lacunar infarction | 13.00 | 11.70 | 66 | 334123 | 3120 | 32176217 |
Euphoric mood | 13 | 11.70 | 21 | 334168 | 5206 | 32174131 |
Spur cell anaemia | 13.00 | 11.70 | 8 | 334181 | 53 | 32179284 |
Carcinoid tumour of the gastrointestinal tract | 13.00 | 11.70 | 8 | 334181 | 53 | 32179284 |
Tendon pain | 13.00 | 11.70 | 60 | 334129 | 2728 | 32176609 |
Inclusion body myositis | 12.94 | 11.70 | 6 | 334183 | 20 | 32179317 |
Pneumothorax | 12.81 | 11.70 | 117 | 334072 | 17453 | 32161884 |
Periodontitis | 12.79 | 11.70 | 46 | 334143 | 1865 | 32177472 |
Infective exacerbation of chronic obstructive airways disease | 12.77 | 11.70 | 45 | 334144 | 1806 | 32177531 |
Gastric ulcer haemorrhage | 12.74 | 11.70 | 100 | 334089 | 5507 | 32173830 |
Autoimmune hepatitis | 12.66 | 11.70 | 77 | 334112 | 3898 | 32175439 |
Escherichia infection | 12.58 | 11.70 | 35 | 334154 | 7125 | 32172212 |
Splenomegaly | 12.57 | 11.70 | 92 | 334097 | 14385 | 32164952 |
Cutaneous lupus erythematosus | 12.57 | 11.70 | 25 | 334164 | 706 | 32178631 |
Peritonitis bacterial | 12.57 | 11.70 | 76 | 334113 | 12420 | 32166917 |
Atrioventricular block complete | 12.56 | 11.70 | 144 | 334045 | 8800 | 32170537 |
Muscle contractions involuntary | 12.56 | 11.70 | 46 | 334143 | 1882 | 32177455 |
Gait inability | 12.55 | 11.70 | 282 | 333907 | 19765 | 32159572 |
Implantable defibrillator insertion | 12.54 | 11.70 | 25 | 334164 | 707 | 32178630 |
Blood electrolytes abnormal | 12.51 | 11.70 | 30 | 334159 | 965 | 32178372 |
Intraventricular haemorrhage | 12.47 | 11.70 | 65 | 334124 | 3105 | 32176232 |
Pulmonary tuberculosis | 12.45 | 11.70 | 20 | 334169 | 4969 | 32174368 |
Occult blood positive | 12.44 | 11.70 | 78 | 334111 | 3991 | 32175346 |
Small intestinal obstruction | 12.43 | 11.70 | 90 | 334099 | 14106 | 32165231 |
Catheter site haematoma | 12.40 | 11.70 | 12 | 334177 | 166 | 32179171 |
Laryngeal haematoma | 12.35 | 11.70 | 11 | 334178 | 136 | 32179201 |
Nausea | 12.34 | 11.70 | 3018 | 331171 | 317831 | 31861506 |
Benign prostatic hyperplasia | 12.32 | 11.70 | 187 | 334002 | 12177 | 32167160 |
Sinonasal obstruction | 12.31 | 11.70 | 6 | 334183 | 23 | 32179314 |
Spermatozoa abnormal | 12.31 | 11.70 | 8 | 334181 | 59 | 32179278 |
Streptococcal infection | 12.28 | 11.70 | 20 | 334169 | 4942 | 32174395 |
Abnormal loss of weight | 12.26 | 11.70 | 77 | 334112 | 3942 | 32175395 |
Aplastic anaemia | 12.26 | 11.70 | 37 | 334152 | 7336 | 32172001 |
Thrombosis in device | 12.25 | 11.70 | 70 | 334119 | 3464 | 32175873 |
Lipid metabolism disorder | 12.22 | 11.70 | 15 | 334174 | 275 | 32179062 |
Hyponatraemic syndrome | 12.21 | 11.70 | 14 | 334175 | 238 | 32179099 |
Decreased gait velocity | 12.16 | 11.70 | 11 | 334178 | 139 | 32179198 |
Adenocarcinoma gastric | 12.14 | 11.70 | 34 | 334155 | 1204 | 32178133 |
Vascular graft occlusion | 12.14 | 11.70 | 23 | 334166 | 626 | 32178711 |
Brain stem haematoma | 12.09 | 11.70 | 11 | 334178 | 140 | 32179197 |
Haemorrhagic transformation stroke | 12.07 | 11.70 | 36 | 334153 | 1322 | 32178015 |
Oesophageal pain | 12.07 | 11.70 | 26 | 334163 | 778 | 32178559 |
Idiopathic pulmonary fibrosis | 12.06 | 11.70 | 82 | 334107 | 4313 | 32175024 |
Delusion | 12.02 | 11.70 | 82 | 334107 | 13026 | 32166311 |
Mitochondrial toxicity | 12.00 | 11.70 | 6 | 334183 | 2624 | 32176713 |
Heart valve incompetence | 11.97 | 11.70 | 35 | 334154 | 1271 | 32178066 |
Subdural haematoma | 11.97 | 11.70 | 279 | 333910 | 19674 | 32159663 |
Lower gastrointestinal haemorrhage | 11.96 | 11.70 | 141 | 334048 | 8676 | 32170661 |
Urine flow decreased | 11.95 | 11.70 | 34 | 334155 | 1215 | 32178122 |
Coronary artery surgery | 11.95 | 11.70 | 10 | 334179 | 113 | 32179224 |
Accidental overdose | 11.94 | 11.70 | 134 | 334055 | 19205 | 32160132 |
Mean cell volume abnormal | 11.89 | 11.70 | 15 | 334174 | 283 | 32179054 |
Paratracheal lymphadenopathy | 11.88 | 11.70 | 9 | 334180 | 87 | 32179250 |
Pseudohyponatraemia | 11.88 | 11.70 | 9 | 334180 | 87 | 32179250 |
Nonalcoholic fatty liver disease | 11.87 | 11.70 | 16 | 334173 | 323 | 32179014 |
Loss of personal independence in daily activities | 11.86 | 11.70 | 199 | 333990 | 26634 | 32152703 |
Liver transplant rejection | 11.85 | 11.70 | 4 | 334185 | 2215 | 32177122 |
Dysmorphism | 11.83 | 11.70 | 7 | 334182 | 2786 | 32176551 |
Mouth swelling | 11.80 | 11.70 | 42 | 334147 | 1694 | 32177643 |
Blood alkaline phosphatase abnormal | 11.79 | 11.70 | 19 | 334170 | 453 | 32178884 |
Skin discomfort | 11.78 | 11.70 | 8 | 334181 | 64 | 32179273 |
BK virus infection | 11.78 | 11.70 | 20 | 334169 | 4861 | 32174476 |
Cold sweat | 11.75 | 11.70 | 155 | 334034 | 9791 | 32169546 |
Pleural effusion | 11.73 | 11.70 | 678 | 333511 | 78314 | 32101023 |
Blood glucose fluctuation | 11.73 | 11.70 | 76 | 334113 | 3933 | 32175404 |
Intestinal obstruction | 11.73 | 11.70 | 147 | 334042 | 20651 | 32158686 |
Flatulence | 11.72 | 11.70 | 271 | 333918 | 19084 | 32160253 |
Inflammation | 11.71 | 11.70 | 179 | 334010 | 24314 | 32155023 |
Source | Code | Description |
---|---|---|
ATC | C10AA05 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, PLAIN HMG CoA reductase inhibitors |
ATC | C10BA05 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Combinations of various lipid modifying agents |
ATC | C10BA08 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Combinations of various lipid modifying agents |
ATC | C10BX03 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX06 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX08 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX11 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX12 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX15 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX18 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
FDA MoA | N0000000121 | Hydroxymethylglutaryl-CoA Reductase Inhibitors |
FDA EPC | N0000175589 | HMG-CoA Reductase Inhibitor |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:78298 | environmental contaminants |
MeSH PA | D000924 | Anticholesteremic Agents |
MeSH PA | D000963 | Antimetabolites |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D019161 | Hydroxymethylglutaryl-CoA Reductase Inhibitors |
MeSH PA | D000960 | Hypolipidemic Agents |
MeSH PA | D057847 | Lipid Regulating Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypercholesterolemia | indication | 13644009 | |
Arteriosclerotic vascular disease | indication | 72092001 | |
Prinzmetal angina | indication | 87343002 | |
Angina pectoris | indication | 194828000 | |
Cerebrovascular accident | indication | 230690007 | |
Familial hypercholesterolemia - homozygous | indication | 238078005 | |
Familial hypercholesterolemia - heterozygous | indication | 238079002 | |
Mixed hyperlipidemia | indication | 267434003 | |
Hypertriglyceridemia | indication | 302870006 | |
Familial type 3 hyperlipoproteinemia | indication | 398796005 | DOID:3145 |
Slow Progression of Coronary Artery Disease | indication | ||
Primary Prevention of Coronary Heart Disease | indication | ||
Myocardial Infarction Prevention | indication | ||
Prevention of Transient Ischemic Attacks | off-label use | ||
Alcoholism | contraindication | 7200002 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Low blood pressure | contraindication | 45007003 | |
Hepatic failure | contraindication | 59927004 | |
Chronic idiopathic constipation | contraindication | 82934008 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Liver function tests abnormal | contraindication | 166603001 | |
Hemorrhagic cerebral infarction | contraindication | 230706003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Rhabdomyolysis | contraindication | 240131006 | |
Pregnancy, function | contraindication | 289908002 | |
Surgical procedure | contraindication | 387713003 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Traumatic injury | contraindication | 417746004 | |
Severe Aortic Valve Stenosis | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.44 | acidic |
pKa2 | 11.82 | acidic |
pKa3 | 13.63 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-coenzyme A reductase | Enzyme | INHIBITOR | IC50 | 8 | WOMBAT-PK | CHEMBL | |||
Cytochrome P450 3A4 | Enzyme | IC50 | 5.29 | CHEMBL | |||||
Histone deacetylase 2 | Enzyme | IC50 | 4.65 | CHEMBL | |||||
Histone deacetylase 1 | Enzyme | IC50 | 4.93 | CHEMBL | |||||
Histone deacetylase 6 | Enzyme | IC50 | 4.84 | CHEMBL | |||||
Nuclear receptor subfamily 1 group I member 3 | Nuclear hormone receptor | WOMBAT-PK | |||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase | Enzyme | IC50 | 8.42 | CHEMBL | |||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase | Enzyme | IC50 | 4.49 | CHEMBL |
ID | Source |
---|---|
4024041 | VUID |
N0000022046 | NUI |
D00887 | KEGG_DRUG |
134523-03-8 | SECONDARY_CAS_RN |
1297766 | RXNORM |
C0286651 | UMLSCUI |
CHEBI:39548 | CHEBI |
117 | PDB_CHEM_ID |
CHEMBL1487 | ChEMBL_ID |
CHEMBL393220 | ChEMBL_ID |
CHEMBL1790017 | ChEMBL_ID |
D000069059 | MESH_DESCRIPTOR_UI |
DB01076 | DRUGBANK_ID |
2949 | IUPHAR_LIGAND_ID |
7259 | INN_ID |
A0JWA85V8F | UNII |
60823 | PUBCHEM_CID |
186242 | MMSL |
34584 | MMSL |
4226 | MMSL |
d04105 | MMSL |
006321 | NDDF |
006322 | NDDF |
108600003 | SNOMEDCT_US |
108601004 | SNOMEDCT_US |
373444002 | SNOMEDCT_US |
725658002 | SNOMEDCT_US |
4020999 | VANDF |
4024041 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2150 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2160 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2170 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2180 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2190 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2250 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2260 | TABLET, FILM COATED | 80 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2270 | TABLET, FILM COATED | 80 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2960 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2970 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2980 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 32 sections |
Lipitor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0155 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 29 sections |
Lipitor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0156 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 29 sections |
Lipitor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0157 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 29 sections |
Lipitor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0158 | TABLET, FILM COATED | 80 mg | ORAL | NDA | 29 sections |
Atorvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5056 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 28 sections |
Atorvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5057 | TABLET, FILM COATED | 80 mg | ORAL | ANDA | 28 sections |
Atorvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5058 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 28 sections |
Atorvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5059 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 28 sections |
Atorvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3950 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 29 sections |
Atorvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3951 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 29 sections |
Atorvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3952 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 29 sections |
Atorvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3953 | TABLET, FILM COATED | 80 mg | ORAL | ANDA | 29 sections |
Amlodipine and atorvastatin | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-4510 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 29 sections |
Amlodipine and atorvastatin | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-4511 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 29 sections |
Amlodipine and atorvastatin | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-4512 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 29 sections |
Amlodipine and atorvastatin | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-4513 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 29 sections |
Amlodipine and atorvastatin | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-4514 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 29 sections |
Amlodipine and atorvastatin | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-4515 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 29 sections |
Amlodipine and atorvastatin | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-4516 | TABLET, FILM COATED | 80 mg | ORAL | ANDA | 29 sections |