riboflavin phosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2374 130-40-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • riboflavin sodium phosphate
  • RIBOFLAVIN 5'-PHOSPHATE SODIUM
  • riboflavin phosphate
  • vitamin B2 phosphate
  • riboflavin 5'-(dihydrogen phosphate)
  • flavin mononucleotide
A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
  • Molecular weight: 456.35
  • Formula: C17H21N4O9P
  • CLOGP: -2.60
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 6
  • TPSA: 201.58
  • ALOGS: -2.83
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Corneal thinning 23.56 20.11 4 1926 103 50603091

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Corneal opacity 102.50 24.50 17 860 496 29573154
Corneal epithelium defect 93.69 24.50 15 862 349 29573301
Corneal infiltrates 67.44 24.50 10 867 137 29573513
Corneal scar 45.25 24.50 7 870 129 29573521
Ulcerative keratitis 34.04 24.50 8 869 1415 29572235
Corneal thinning 30.63 24.50 5 872 131 29573519
Corneal oedema 30.38 24.50 7 870 1135 29572515
Keratitis 24.76 24.50 6 871 1206 29572444

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Corneal opacity 87.78 20.32 17 2547 888 64495280
Corneal infiltrates 64.70 20.32 11 2553 274 64495894
Corneal epithelium defect 55.07 20.32 11 2553 674 64495494
Corneal thinning 41.87 20.32 7 2557 157 64496011
Corneal scar 25.68 20.32 5 2559 268 64495900
Keratitis 21.11 20.32 7 2557 3230 64492938

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:23354 coenzymes
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.57 acidic
pKa2 6.62 acidic
pKa3 10.13 acidic
pKa4 12.34 acidic
pKa5 13.19 acidic
pKa6 2.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
0.146% PHOTREXA GLAUKOS N203324 April 15, 2016 RX SOLUTION/DROPS OPHTHALMIC April 15, 2023 TREATMENT OF PROGRESSIVE KERATOCONUS
0.146% PHOTREXA VISCOUS IN DEXTRAN 20% GLAUKOS N203324 April 15, 2016 RX SOLUTION/DROPS OPHTHALMIC April 15, 2023 TREATMENT OF PROGRESSIVE KERATOCONUS
0.146% PHOTREXA GLAUKOS N203324 April 15, 2016 RX SOLUTION/DROPS OPHTHALMIC July 15, 2023 TREATMENT OF CORNEAL ECTASIA FOLLOWING REFRACTIVE SURGERY
0.146% PHOTREXA VISCOUS IN DEXTRAN 20% GLAUKOS N203324 April 15, 2016 RX SOLUTION/DROPS OPHTHALMIC July 15, 2023 TREATMENT OF CORNEAL ECTASIA FOLLOWING REFRACTIVE SURGERY

Bioactivity Summary:

None

External reference:

IDSource
4017670 VUID
N0000178985 NUI
D01622 KEGG_DRUG
6184-17-4 SECONDARY_CAS_RN
4017670 VANDF
4017770 VANDF
C0016388 UMLSCUI
CHEBI:32098 CHEBI
FMN PDB_CHEM_ID
CHEMBL1201794 ChEMBL_ID
643976 PUBCHEM_CID
DB03247 DRUGBANK_ID
CHEMBL3989697 ChEMBL_ID
5185 IUPHAR_LIGAND_ID
20RD1DZH99 UNII
1925820 RXNORM
31895 MMSL
001060 NDDF
014666 NDDF
442346000 SNOMEDCT_US
53499005 SNOMEDCT_US
D005486 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Photrexa Viscous HUMAN PRESCRIPTION DRUG LABEL 1 25357-022 SOLUTION/ DROPS 1.46 mg OPHTHALMIC NDA 21 sections
Photrexa HUMAN PRESCRIPTION DRUG LABEL 1 25357-023 SOLUTION/ DROPS 1.46 mg OPHTHALMIC NDA 21 sections
B-PLEX 100 HUMAN PRESCRIPTION DRUG LABEL 5 30727-300 INJECTION, SOLUTION 2 mg INTRAMUSCULAR unapproved drug other 10 sections
PEDIATRIC INFUVITE MULTIPLE VITAMINS FOR INFUSION HUMAN PRESCRIPTION DRUG LABEL 13 54643-5646 INJECTION, SOLUTION 1.40 mg INTRAVENOUS NDA 19 sections
Adult Infuvite Multiple Vitamins for Infusion HUMAN PRESCRIPTION DRUG LABEL 13 54643-5649 INJECTION, SOLUTION 3.60 mg INTRAVENOUS NDA 17 sections
Adult Infuvite Multiple Vitamins for Infusion HUMAN PRESCRIPTION DRUG LABEL 13 54643-5649 INJECTION, SOLUTION 3.60 mg INTRAVENOUS NDA 17 sections
Infuvite Adult Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-5650 INJECTION, SOLUTION 3.60 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7862 INJECTION, SOLUTION 3.60 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7874 INJECTION, SOLUTION 3.60 mg INTRAVENOUS NDA 20 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7886 INJECTION, SOLUTION 1.40 mg INTRAVENOUS NDA 19 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9007 INJECTION, SOLUTION 3.60 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9015 INJECTION, SOLUTION 3.60 mg INTRAVENOUS NDA 20 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9023 INJECTION, SOLUTION 1.40 mg INTRAVENOUS NDA 19 sections
Multi-Vitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 10 58657-325 LIQUID 0.60 mg ORAL unapproved drug other 10 sections
Multi-Vitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 10 58657-326 LIQUID 0.60 mg ORAL unapproved drug other 10 sections
Multi-Vitamin Drops with Fluoride and Iron HUMAN PRESCRIPTION DRUG LABEL 10 58657-327 LIQUID 0.60 mg ORAL unapproved drug other 10 sections
Vitamin B Complex HUMAN PRESCRIPTION DRUG LABEL 5 67457-146 INJECTION 2 mg INTRAVENOUS Unapproved drug other 9 sections
Vitamin B Complex HUMAN PRESCRIPTION DRUG LABEL 5 69877-026 INJECTION, SOLUTION 2 mg INTRAMUSCULAR unapproved drug other 10 sections
VITAMIN B COMPLEX HUMAN PRESCRIPTION DRUG LABEL 5 71414-225 INJECTION 2 mg INTRAVENOUS unapproved drug other 9 sections