progabide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
gabamimetic agents 2278 62666-20-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • progabide
  • halogabide
  • gabrene
  • gabren
GABA agonist; structure
  • Molecular weight: 334.78
  • Formula: C17H16ClFN2O2
  • CLOGP: 2.90
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 75.68
  • ALOGS: -4.68
  • ROTB: 6

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1985 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N03AG05 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Fatty acid derivatives
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D000927 Anticonvulsants
MeSH PA D000928 Antidepressive Agents
MeSH PA D000978 Antiparkinson Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018682 GABA Agents
MeSH PA D018755 GABA Agonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.28 acidic
pKa2 13.0 acidic
pKa3 3.38 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel Ki 4.40 WOMBAT-PK
GABA-A receptor; anion channel Ion channel Ki 4.40 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 4.85 CHEMBL

External reference:

IDSource
D05621 KEGG_DRUG
C0072076 UMLSCUI
CHEBI:135422 CHEBI
CHEMBL287631 ChEMBL_ID
DB00837 DRUGBANK_ID
C017985 MESH_SUPPLEMENTAL_RECORD_UI
44115 PUBCHEM_CID
4656 INN_ID
38C836J57Z UNII
34568 RXNORM
005334 NDDF

Pharmaceutical products:

None