pentagastrin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2088 5534-95-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pentagastrin
  • pentavlon
  • peptavlon
  • ICI 50123
A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.
  • Molecular weight: 767.90
  • Formula: C37H49N7O9S
  • CLOGP: 1.74
  • LIPINSKI: 3
  • HAC: 16
  • HDO: 8
  • TPSA: 250.91
  • ALOGS: -5.47
  • ROTB: 22

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 26, 1974 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V04CG04 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for gastric secretion

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.79 acidic
pKa2 12.72 acidic
pKa3 13.16 acidic
pKa4 13.54 acidic
pKa5 13.97 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Gastrin/cholecystokinin type B receptor GPCR Ki 7.84 CHEMBL
Cholecystokinin receptor type A GPCR IC50 6.22 CHEMBL
Gastrin/cholecystokinin type B receptor GPCR IC50 8.17 CHEMBL
Gastrin/cholecystokinin type B receptor GPCR IC50 9.10 CHEMBL

External reference:

IDSource
4018500 VUID
N0000146822 NUI
D01631 KEGG_DRUG
4018500 VANDF
C0030859 UMLSCUI
CHEBI:31974 CHEBI
CHEMBL1328 ChEMBL_ID
D010418 MESH_DESCRIPTOR_UI
DB00183 DRUGBANK_ID
870 IUPHAR_LIGAND_ID
2387 INN_ID
EF0NX91490 UNII
9853654 PUBCHEM_CID
204262 RXNORM
2234 MMSL
5249 MMSL
d04022 MMSL
001146 NDDF
10782005 SNOMEDCT_US
358180008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Pentagastrin HUMAN PRESCRIPTION DRUG LABEL 1 51808-207 SOLUTION 250 ug INTRAVENOUS Unapproved drug other 6 sections