paraldehyde 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2058 | 123-63-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A hypnotic and sedative with anticonvulsant effects. However, because of the hazards associated with its administration, its tendency to react with plastic, and the risks associated with its deterioration, it has largely been superseded by other agents. It is still occasionally used to control status epilepticus resistant to conventional treatment. (From Martindale, The Extra Pharmacopoeia, 30th ed, p608-9)
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 5 | g | O |
| 5 | g | P |
| 5 | g | R |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 3242.82 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Sedation | 244.03 | 182.31 | 44 | 84 | 20962 | 34935841 |
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05CC05 | NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Aldehydes and derivatives |
| MeSH PA | D000927 | Anticonvulsants |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D006993 | Hypnotics and Sedatives |
| CHEBI has role | CHEBI:35717 | hypnotics |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4018195 | VUID |
| N0000146529 | NUI |
| D00705 | KEGG_DRUG |
| 4018195 | VANDF |
| C0030438 | UMLSCUI |
| CHEBI:27909 | CHEBI |
| CHEMBL1410743 | ChEMBL_ID |
| 31264 | PUBCHEM_CID |
| DB09117 | DRUGBANK_ID |
| D010242 | MESH_DESCRIPTOR_UI |
| S6M3YBG8QA | UNII |
| 7909 | RXNORM |
| 42494 | MMSL |
| 5232 | MMSL |
| d00911 | MMSL |
| 001429 | NDDF |
| 35324004 | SNOMEDCT_US |
| 387190006 | SNOMEDCT_US |
Pharmaceutical products:
None