metharbital 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
hypnotics, barbituric acid derivatives 1740 50-11-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metharbital
  • metabarbital
  • methabarbitone
  • metharbitone
  • methylbarbital
  • N-Methylbarbital
  • Molecular weight: 198.22
  • Formula: C9H14N2O3
  • CLOGP: 1.14
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 66.48
  • ALOGS: -1.01
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA ABBVIE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N03AA30 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Barbiturates and derivatives

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Epilepsy indication 84757009 DOID:1826
Insomnia indication 193462001
Tonic-clonic epilepsy indication 352818000 DOID:7725




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.43 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL

External reference:

IDSource
4018729 VUID
N0000147034 NUI
D01382 KEGG_DRUG
4018729 VANDF
C0025629 UMLSCUI
CHEBI:31827 CHEBI
VOK PDB_CHEM_ID
CHEMBL450 ChEMBL_ID
DB00463 DRUGBANK_ID
4099 PUBCHEM_CID
2 INN_ID
C084822 MESH_SUPPLEMENTAL_RECORD_UI
7230 IUPHAR_LIGAND_ID
02OS7K758T UNII
6825 RXNORM
001419 NDDF
30676006 SNOMEDCT_US

Pharmaceutical products:

None