menatetrenone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1685 863-61-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • menatetrenone
  • Menaquinone 4
  • Vitamin MK 4
  • vitamin k2
  • Molecular weight: 444.66
  • Formula: C31H40O2
  • CLOGP: 10.56
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS: -5.96
  • ROTB: 11

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 35.84 25.73 18 1284 34403 46650357
Cerebral infarction 29.66 25.73 14 1288 23352 46661408
Platelet count decreased 28.47 25.73 23 1279 100001 46584759

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cerebral haemorrhage 74.66 29.87 31 951 32856 29918640
Cerebral infarction 31.67 29.87 16 966 26357 29925139
Disseminated intravascular coagulation 31.24 29.87 15 967 22156 29929340
Platelet count decreased 30.03 29.87 26 956 106103 29845393

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003029 Coagulants
MeSH PA D006401 Hematologic Agents
MeSH PA D006490 Hemostatics
CHEBI has role CHEBI:76971 e.coli metabolites
CHEBI has role CHEBI:50646 anti-osteoporotics
CHEBI has role CHEBI:77746 h. sapiens metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hemorrhagic disease of the newborn due to vitamin K deficiency indication 12546009

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cruzipain Enzyme IC50 4.74 CHEMBL

External reference:

IDSource
D00100 KEGG_DRUG
C0065936 UMLSCUI
CHEBI:78277 CHEBI
CHEMBL259223 ChEMBL_ID
DB12148 DRUGBANK_ID
C030814 MESH_SUPPLEMENTAL_RECORD_UI
3292 INN_ID
27Y876D139 UNII
5282367 PUBCHEM_CID
2771 IUPHAR_LIGAND_ID
DB14936 DRUGBANK_ID
29495 RXNORM
337527 MMSL
35482 MMSL
37263 MMSL
d09345 MMSL
012756 NDDF
013766 NDDF
22606007 SNOMEDCT_US
712684001 SNOMEDCT_US

Pharmaceutical products:

None