menatetrenone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1685 | 863-61-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hepatic function abnormal | 35.22 | 23.73 | 18 | 1420 | 36881 | 53310747 |
| Cerebral infarction | 32.61 | 23.73 | 15 | 1423 | 24429 | 53323199 |
| Platelet count decreased | 29.68 | 23.73 | 24 | 1414 | 108075 | 53239553 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cerebral haemorrhage | 73.23 | 27.41 | 31 | 1026 | 34716 | 32477753 |
| Cerebral infarction | 34.02 | 27.41 | 17 | 1040 | 27597 | 32484872 |
| Disseminated intravascular coagulation | 33.76 | 27.41 | 16 | 1041 | 23160 | 32489309 |
| Hepatic function abnormal | 31.39 | 27.41 | 19 | 1038 | 44821 | 32467648 |
| Platelet count decreased | 30.46 | 27.41 | 27 | 1030 | 114564 | 32397905 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D003029 | Coagulants |
| MeSH PA | D006401 | Hematologic Agents |
| MeSH PA | D006490 | Hemostatics |
| CHEBI has role | CHEBI:76971 | E.coli metabolites |
| CHEBI has role | CHEBI:22586 | antioxidants |
| CHEBI has role | CHEBI:50646 | anti-osteoporotics |
| CHEBI has role | CHEBI:63726 | neuroprotective agents |
| CHEBI has role | CHEBI:67079 | antiinflammatory agents |
| CHEBI has role | CHEBI:77746 | H. sapiens metabolites |
| MeSH PA | D000933 | Antifibrinolytic Agents |
| MeSH PA | D018977 | Micronutrients |
| MeSH PA | D014815 | Vitamins |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hemorrhagic disease of the newborn due to vitamin K deficiency | indication | 12546009 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cruzipain | Enzyme | IC50 | 4.74 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D00100 | KEGG_DRUG |
| C0065936 | UMLSCUI |
| CHEBI:16374 | CHEBI |
| CHEMBL259223 | ChEMBL_ID |
| DB12148 | DRUGBANK_ID |
| C030814 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2771 | IUPHAR_LIGAND_ID |
| 3292 | INN_ID |
| 27Y876D139 | UNII |
| 5282367 | PUBCHEM_CID |
| DB14936 | DRUGBANK_ID |
| 29495 | RXNORM |
| 337527 | MMSL |
| 35482 | MMSL |
| 37263 | MMSL |
| d09345 | MMSL |
| 012756 | NDDF |
| 013766 | NDDF |
| 22606007 | SNOMEDCT_US |
| 712684001 | SNOMEDCT_US |
| D024482 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
None