menatetrenone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1685 | 863-61-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hepatic function abnormal | 35.84 | 25.73 | 18 | 1284 | 34403 | 46650357 |
| Cerebral infarction | 29.66 | 25.73 | 14 | 1288 | 23352 | 46661408 |
| Platelet count decreased | 28.47 | 25.73 | 23 | 1279 | 100001 | 46584759 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cerebral haemorrhage | 74.66 | 29.87 | 31 | 951 | 32856 | 29918640 |
| Cerebral infarction | 31.67 | 29.87 | 16 | 966 | 26357 | 29925139 |
| Disseminated intravascular coagulation | 31.24 | 29.87 | 15 | 967 | 22156 | 29929340 |
| Platelet count decreased | 30.03 | 29.87 | 26 | 956 | 106103 | 29845393 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D003029 | Coagulants |
| MeSH PA | D006401 | Hematologic Agents |
| MeSH PA | D006490 | Hemostatics |
| CHEBI has role | CHEBI:76971 | e.coli metabolites |
| CHEBI has role | CHEBI:50646 | anti-osteoporotics |
| CHEBI has role | CHEBI:77746 | h. sapiens metabolites |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hemorrhagic disease of the newborn due to vitamin K deficiency | indication | 12546009 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cruzipain | Enzyme | IC50 | 4.74 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D00100 | KEGG_DRUG |
| C0065936 | UMLSCUI |
| CHEBI:78277 | CHEBI |
| CHEMBL259223 | ChEMBL_ID |
| DB12148 | DRUGBANK_ID |
| C030814 | MESH_SUPPLEMENTAL_RECORD_UI |
| 3292 | INN_ID |
| 27Y876D139 | UNII |
| 5282367 | PUBCHEM_CID |
| 2771 | IUPHAR_LIGAND_ID |
| DB14936 | DRUGBANK_ID |
| 29495 | RXNORM |
| 337527 | MMSL |
| 35482 | MMSL |
| 37263 | MMSL |
| d09345 | MMSL |
| 012756 | NDDF |
| 013766 | NDDF |
| 22606007 | SNOMEDCT_US |
| 712684001 | SNOMEDCT_US |
Pharmaceutical products:
None