menatetrenone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1685 863-61-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • menatetrenone
  • Menaquinone 4
  • Vitamin MK 4
  • vitamin k2
  • Molecular weight: 444.66
  • Formula: C31H40O2
  • CLOGP: 10.56
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS: -5.96
  • ROTB: 11

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 35.22 23.73 18 1420 36881 53310747
Cerebral infarction 32.61 23.73 15 1423 24429 53323199
Platelet count decreased 29.68 23.73 24 1414 108075 53239553

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cerebral haemorrhage 73.23 27.41 31 1026 34716 32477753
Cerebral infarction 34.02 27.41 17 1040 27597 32484872
Disseminated intravascular coagulation 33.76 27.41 16 1041 23160 32489309
Hepatic function abnormal 31.39 27.41 19 1038 44821 32467648
Platelet count decreased 30.46 27.41 27 1030 114564 32397905

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003029 Coagulants
MeSH PA D006401 Hematologic Agents
MeSH PA D006490 Hemostatics
CHEBI has role CHEBI:76971 E.coli metabolites
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:50646 anti-osteoporotics
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:67079 antiinflammatory agents
CHEBI has role CHEBI:77746 H. sapiens metabolites
MeSH PA D000933 Antifibrinolytic Agents
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hemorrhagic disease of the newborn due to vitamin K deficiency indication 12546009

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cruzipain Enzyme IC50 4.74 CHEMBL

External reference:

IDSource
D00100 KEGG_DRUG
C0065936 UMLSCUI
CHEBI:16374 CHEBI
CHEMBL259223 ChEMBL_ID
DB12148 DRUGBANK_ID
C030814 MESH_SUPPLEMENTAL_RECORD_UI
2771 IUPHAR_LIGAND_ID
3292 INN_ID
27Y876D139 UNII
5282367 PUBCHEM_CID
DB14936 DRUGBANK_ID
29495 RXNORM
337527 MMSL
35482 MMSL
37263 MMSL
d09345 MMSL
012756 NDDF
013766 NDDF
22606007 SNOMEDCT_US
712684001 SNOMEDCT_US
D024482 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None