Stem definition | Drug id | CAS RN |
---|---|---|
1685 | 863-61-6 |
Molecule | Description |
---|---|
Synonyms:
|
|
None
None
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hepatic function abnormal | 35.22 | 23.73 | 18 | 1420 | 36881 | 53310747 |
Cerebral infarction | 32.61 | 23.73 | 15 | 1423 | 24429 | 53323199 |
Platelet count decreased | 29.68 | 23.73 | 24 | 1414 | 108075 | 53239553 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cerebral haemorrhage | 73.23 | 27.41 | 31 | 1026 | 34716 | 32477753 |
Cerebral infarction | 34.02 | 27.41 | 17 | 1040 | 27597 | 32484872 |
Disseminated intravascular coagulation | 33.76 | 27.41 | 16 | 1041 | 23160 | 32489309 |
Hepatic function abnormal | 31.39 | 27.41 | 19 | 1038 | 44821 | 32467648 |
Platelet count decreased | 30.46 | 27.41 | 27 | 1030 | 114564 | 32397905 |
Source | Code | Description |
---|---|---|
MeSH PA | D003029 | Coagulants |
MeSH PA | D006401 | Hematologic Agents |
MeSH PA | D006490 | Hemostatics |
CHEBI has role | CHEBI:76971 | E.coli metabolites |
CHEBI has role | CHEBI:22586 | antioxidants |
CHEBI has role | CHEBI:50646 | anti-osteoporotics |
CHEBI has role | CHEBI:63726 | neuroprotective agents |
CHEBI has role | CHEBI:67079 | antiinflammatory agents |
CHEBI has role | CHEBI:77746 | H. sapiens metabolites |
MeSH PA | D000933 | Antifibrinolytic Agents |
MeSH PA | D018977 | Micronutrients |
MeSH PA | D014815 | Vitamins |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hemorrhagic disease of the newborn due to vitamin K deficiency | indication | 12546009 |
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Cruzipain | Enzyme | IC50 | 4.74 | CHEMBL |
ID | Source |
---|---|
D00100 | KEGG_DRUG |
C0065936 | UMLSCUI |
CHEBI:16374 | CHEBI |
CHEMBL259223 | ChEMBL_ID |
DB12148 | DRUGBANK_ID |
C030814 | MESH_SUPPLEMENTAL_RECORD_UI |
2771 | IUPHAR_LIGAND_ID |
3292 | INN_ID |
27Y876D139 | UNII |
5282367 | PUBCHEM_CID |
DB14936 | DRUGBANK_ID |
29495 | RXNORM |
337527 | MMSL |
35482 | MMSL |
37263 | MMSL |
d09345 | MMSL |
012756 | NDDF |
013766 | NDDF |
22606007 | SNOMEDCT_US |
712684001 | SNOMEDCT_US |
D024482 | MESH_DESCRIPTOR_UI |
None