loxoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 1615 68767-14-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • loxoprofen sodium hydrate
  • loxonin
  • loxoprofen
  • loxoprofen sodium
  • sodium loxoprofen
  • Molecular weight: 246.31
  • Formula: C15H18O3
  • CLOGP: 1.97
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 54.37
  • ALOGS: -3.57
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 23, 2006 PMDA Lead Chemical Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 281.66 19.29 162 10597 53014 50541351
Platelet count decreased 281.07 19.29 205 10554 100521 50493844
Hepatic function abnormal 212.42 19.29 114 10645 32567 50561798
Malignant neoplasm progression 157.30 19.29 124 10635 68000 50526365
Neutrophil count decreased 142.59 19.29 100 10659 45926 50548439
Osteonecrosis of jaw 120.58 19.29 79 10680 32447 50561918
Anaemia 111.18 19.29 195 10564 252261 50342104
White blood cell count decreased 110.62 19.29 130 10629 116592 50477773
Fatigue 99.43 19.29 16 10743 707585 49886780
Disseminated intravascular coagulation 98.06 19.29 55 10704 17080 50577285
Drug eruption 96.52 19.29 61 10698 23545 50570820
Drug ineffective 85.57 19.29 34 10725 819299 49775066
Gastrointestinal perforation 70.56 19.29 26 10733 3035 50591330
Decreased appetite 70.55 19.29 141 10618 200782 50393583
Spinal compression fracture 68.03 19.29 39 10720 12617 50581748
Cerebral infarction 66.98 19.29 47 10712 21557 50572808
Erythema multiforme 65.62 19.29 34 10725 9016 50585349
Upper respiratory tract inflammation 61.44 19.29 22 10737 2367 50591998
Enterocolitis 57.39 19.29 28 10731 6539 50587826
Renal impairment 53.65 19.29 73 10686 75588 50518777
Cardiac failure 53.37 19.29 73 10686 75967 50518398
Pneumonia bacterial 51.67 19.29 27 10732 7282 50587083
Haemorrhage subcutaneous 51.60 19.29 20 10739 2681 50591684
Altered state of consciousness 50.73 19.29 40 10719 21870 50572495
Pyrexia 50.36 19.29 186 10573 380017 50214348
Febrile neutropenia 50.19 19.29 81 10678 97586 50496779
Drug-induced liver injury 49.90 19.29 44 10715 28051 50566314
Iron deficiency anaemia 46.17 19.29 34 10725 16800 50577565
Enteritis infectious 39.52 19.29 15 10744 1900 50592465
Liver disorder 39.46 19.29 44 10715 37178 50557187
Hypoalbuminaemia 39.09 19.29 25 10734 9835 50584530
Femoral neck fracture 37.38 19.29 22 10737 7468 50586897
Drug intolerance 35.44 19.29 3 10756 219101 50375264
Pain 35.16 19.29 43 10716 578860 50015505
Ileus 34.66 19.29 26 10733 13203 50581162
Drug hypersensitivity 34.36 19.29 6 10753 251004 50343361
Paronychia 32.66 19.29 17 10742 4547 50589818
Aspartate aminotransferase increased 32.55 19.29 59 10700 77939 50516426
Pharyngitis 32.26 19.29 28 10731 17475 50576890
Peritonitis 31.05 19.29 26 10733 15460 50578905
Peripheral swelling 30.29 19.29 4 10755 205932 50388433
Subarachnoid haemorrhage 30.07 19.29 22 10737 10754 50583611
Colon cancer 29.50 19.29 20 10739 8671 50585694
Herpes zoster 28.84 19.29 53 10706 70733 50523632
Alanine aminotransferase increased 27.38 19.29 59 10700 88300 50506065
Gastroenteritis 27.25 19.29 29 10730 23252 50571113
Purpura 27.13 19.29 20 10739 9891 50584474
Swelling 27.05 19.29 5 10754 200867 50393498
Eczema 26.08 19.29 28 10731 22674 50571691
Ascites 26.00 19.29 35 10724 35826 50558539
Pulmonary alveolar haemorrhage 25.99 19.29 14 10745 4013 50590352
Hypopituitarism 25.88 19.29 9 10750 888 50593477
Stevens-Johnson syndrome 25.29 19.29 27 10732 21725 50572640
Stomatitis 25.15 19.29 62 10697 101282 50493083
Asteatosis 25.13 19.29 5 10754 52 50594313
Hyperuricaemia 24.02 19.29 14 10745 4666 50589699
Malignant pleural effusion 23.60 19.29 11 10748 2319 50592046
Atypical femur fracture 23.38 19.29 14 10745 4902 50589463
Lymphangiosis carcinomatosa 23.36 19.29 9 10750 1187 50593178
Weight increased 23.29 19.29 7 10752 201884 50392481
Enterocolitis viral 23.26 19.29 6 10753 211 50594154
Breast cancer 22.59 19.29 36 10723 42854 50551511
Pleural effusion 22.55 19.29 52 10707 81402 50512963
Cancer pain 22.51 19.29 11 10748 2576 50591789
Melaena 22.25 19.29 28 10731 26836 50567529
Pneumocystis jirovecii pneumonia 22.19 19.29 21 10738 14642 50579723
Haemoglobin decreased 21.82 19.29 68 10691 127148 50467217
Toxicity to various agents 21.72 19.29 9 10750 212490 50381875
Lymphoproliferative disorder 21.40 19.29 11 10748 2866 50591499
Blood bilirubin increased 21.31 19.29 30 10729 32008 50562357
Subacute hepatic failure 21.17 19.29 5 10754 121 50594244
Fulminant type 1 diabetes mellitus 20.71 19.29 6 10753 327 50594038
Delirium 20.03 19.29 32 10727 38160 50556205
Liver abscess 19.54 19.29 10 10749 2583 50591782

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 394.33 18.02 241 9428 57477 29507381
Malignant neoplasm progression 215.14 18.02 184 9485 73675 29491183
Platelet count decreased 205 18.02 209 9460 104463 29460395
Hepatic function abnormal 179.90 18.02 128 9541 39131 29525727
White blood cell count decreased 117.02 18.02 140 9529 83222 29481636
Neutrophil count decreased 90.46 18.02 90 9579 43477 29521381
Liver disorder 80.25 18.02 69 9600 27680 29537178
Decreased appetite 71.66 18.02 151 9518 145191 29419667
Osteonecrosis of jaw 58.05 18.02 46 9623 16464 29548394
Stomatitis 51.39 18.02 62 9607 37051 29527807
Disseminated intravascular coagulation 50.40 18.02 46 9623 19934 29544924
Drug ineffective 47.87 18.02 30 9639 363140 29201718
Fatigue 47.84 18.02 22 9647 316799 29248059
Radiation pneumonitis 43.70 18.02 19 9650 2210 29562648
Toxicity to various agents 42.31 18.02 4 9665 173657 29391201
Renal impairment 41.72 18.02 86 9583 81247 29483611
Anaemia 41.59 18.02 152 9517 200799 29364059
Drug eruption 41.16 18.02 38 9631 16703 29548155
Pyrexia 41.05 18.02 194 9475 287428 29277430
Asthenia 39.14 18.02 11 9658 215239 29349619
Delirium 37.81 18.02 55 9614 39342 29525516
Cholangitis 37.76 18.02 26 9643 7511 29557347
Malaise 35.78 18.02 124 9545 159478 29405380
Altered state of consciousness 33.88 18.02 37 9632 19852 29545006
Gastric ulcer 32.80 18.02 31 9638 14030 29550828
Upper respiratory tract inflammation 32.38 18.02 14 9655 1606 29563252
Drug-induced liver injury 31.31 18.02 37 9632 21618 29543240
Erythema multiforme 30.38 18.02 23 9646 7694 29557164
Gastrointestinal perforation 30.11 18.02 17 9652 3466 29561392
Enterocolitis 28.77 18.02 21 9648 6645 29558213
Hyperuricaemia 28.16 18.02 21 9648 6868 29557990
Gastric ulcer haemorrhage 27.11 18.02 18 9651 4896 29559962
Aspartate aminotransferase increased 26.97 18.02 60 9609 59665 29505193
C-reactive protein increased 26.53 18.02 50 9619 44213 29520645
Cerebral infarction 25.95 18.02 36 9633 24639 29540219
Death 25.20 18.02 46 9623 342038 29222820
Blood bilirubin increased 25.09 18.02 42 9627 33851 29531007
Prescribed underdose 23.79 18.02 20 9649 7766 29557092
Pneumonia bacterial 22.56 18.02 21 9648 9322 29555536
Hypotension 21.71 18.02 19 9650 194335 29370523
Infective spondylitis 21.46 18.02 6 9663 185 29564673
Pneumonia aspiration 21.39 18.02 41 9628 36696 29528162
Hypothyroidism 21.07 18.02 26 9643 15880 29548978
Palmar-plantar erythrodysaesthesia syndrome 20.97 18.02 25 9644 14734 29550124
Hypoalbuminaemia 20.81 18.02 21 9648 10284 29554574
Haemorrhage subcutaneous 20.08 18.02 11 9658 2114 29562744
Rash 20.05 18.02 118 9551 189701 29375157
Duodenal perforation 19.72 18.02 9 9660 1173 29563685
Lymphangiosis carcinomatosa 19.51 18.02 8 9661 804 29564054
Pharyngitis 19.43 18.02 17 9652 6966 29557892
Pneumonia 19.35 18.02 174 9495 319998 29244860
Alanine aminotransferase increased 19.35 18.02 59 9610 70885 29493973
Hepatocellular carcinoma 19.31 18.02 17 9652 7021 29557837
Product dose omission issue 19.29 18.02 4 9665 96379 29468479
Peritonitis 19.26 18.02 24 9645 14800 29550058
Constipation 19.18 18.02 81 9588 114079 29450779
Cancer pain 19.06 18.02 11 9658 2336 29562522
Duodenal ulcer 18.98 18.02 19 9650 9219 29555639
Paralysis recurrent laryngeal nerve 18.71 18.02 4 9665 38 29564820
Eosinophil count increased 18.64 18.02 17 9652 7352 29557506
Anxiety 18.25 18.02 3 9666 85362 29479496
Colon cancer 18.08 18.02 17 9652 7638 29557220

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 632.51 15.29 394 20598 97338 64380402
Platelet count decreased 474.35 15.29 410 20582 167301 64310439
Malignant neoplasm progression 372.64 15.29 302 20690 112569 64365171
Hepatic function abnormal 362.64 15.29 238 20754 64075 64413665
White blood cell count decreased 227.21 15.29 268 20724 157569 64320171
Neutrophil count decreased 214.11 15.29 187 20805 77009 64400731
Osteonecrosis of jaw 160.30 15.29 120 20872 39705 64438035
Fatigue 139.88 15.29 36 20956 748694 63729046
Disseminated intravascular coagulation 138.09 15.29 101 20891 32247 64445493
Anaemia 132.48 15.29 343 20649 378337 64099403
Decreased appetite 132.24 15.29 286 20706 281003 64196737
Drug ineffective 122.04 15.29 61 20931 840186 63637554
Drug eruption 119.60 15.29 97 20895 36039 64441701
Liver disorder 112.49 15.29 111 20881 53240 64424500
Gastrointestinal perforation 92.92 15.29 42 20950 5382 64472358
Upper respiratory tract inflammation 86.79 15.29 36 20956 3746 64473994
Erythema multiforme 85.65 15.29 57 20935 15644 64462096
Renal impairment 84.62 15.29 155 20837 134862 64342878
Pyrexia 82.89 15.29 380 20612 558264 63919476
Enterocolitis 78.83 15.29 49 20943 11969 64465771
Cerebral infarction 78.46 15.29 81 20911 40963 64436777
Toxicity to various agents 76.87 15.29 13 20979 363500 64114240
Confusional state 72.12 15.29 3 20989 261141 64216599
Altered state of consciousness 71.00 15.29 74 20918 37828 64439912
Stomatitis 67.61 15.29 125 20867 109480 64368260
Spinal compression fracture 67.29 15.29 48 20944 14727 64463013
Drug-induced liver injury 65.23 15.29 79 20913 47564 64430176
Pneumonia bacterial 64.26 15.29 47 20945 14988 64462752
Haemorrhage subcutaneous 62.97 15.29 30 20962 4331 64473409
Asthenia 62.01 15.29 31 20961 428013 64049727
Completed suicide 57.53 15.29 4 20988 224410 64253330
Hypoalbuminaemia 53.36 15.29 45 20947 17629 64460111
Delirium 51.85 15.29 86 20906 69108 64408632
Hyperuricaemia 50.81 15.29 35 20957 10156 64467584
Febrile neutropenia 50.64 15.29 155 20837 187502 64290238
Pharyngitis 50.45 15.29 45 20947 18994 64458746
Aspartate aminotransferase increased 49.61 15.29 116 20876 119672 64358068
Joint swelling 49.45 15.29 6 20986 215376 64262364
Product dose omission issue 48.42 15.29 4 20988 194743 64282997
Radiation pneumonitis 48.37 15.29 23 20969 3305 64474435
Hypotension 47.51 15.29 33 20959 380941 64096799
Peritonitis 47.12 15.29 49 20943 24974 64452766
Drug hypersensitivity 47.05 15.29 10 20982 237805 64239935
Cardiac failure 46.15 15.29 120 20872 132253 64345487
Colon cancer 45.98 15.29 36 20956 12703 64465037
Blood bilirubin increased 43.75 15.29 72 20920 57481 64420259
Peripheral swelling 43.03 15.29 8 20984 209145 64268595
Pain 42.40 15.29 72 20920 553439 63924301
Drug intolerance 41.32 15.29 6 20986 187986 64289754
Enteritis infectious 41.20 15.29 20 20972 3008 64474732
Lymphangiosis carcinomatosa 40.66 15.29 17 20975 1804 64475936
Cancer pain 40.23 15.29 22 20970 4235 64473505
Gastric ulcer 39.54 15.29 49 20943 30185 64447555
Malaise 38.33 15.29 240 20752 396007 64081733
Dyspnoea 38.32 15.29 114 20878 718560 63759180
Cholangitis 37.85 15.29 30 20962 10772 64466968
Prescribed underdose 37.05 15.29 37 20955 17978 64459762
Alanine aminotransferase increased 36.70 15.29 114 20878 138917 64338823
Femoral neck fracture 36.66 15.29 27 20965 8697 64469043
Ileus 36.29 15.29 41 20951 22925 64454815
Iron deficiency anaemia 36.17 15.29 40 20952 21849 64455891
Pneumonia 35.80 15.29 307 20685 559269 63918471
Herpes zoster 35.33 15.29 79 20913 79108 64398632
Pleural effusion 34.54 15.29 105 20887 126454 64351286
Hypopituitarism 34.41 15.29 17 20975 2656 64475084
C-reactive protein increased 33.02 15.29 86 20906 94823 64382917
Eczema 32.36 15.29 44 20948 29676 64448064
Drug abuse 32.13 15.29 3 20989 132371 64345369
Renal disorder 32.09 15.29 48 20944 35317 64442423
Pain in extremity 31.87 15.29 31 20961 303054 64174686
Asteatosis 31.85 15.29 7 20985 77 64477663
Stevens-Johnson syndrome 31.81 15.29 47 20945 34202 64443538
Pneumocystis jirovecii pneumonia 31.75 15.29 42 20950 27592 64450148
Rhinitis allergic 31.71 15.29 24 20968 8054 64469686
Swelling 31.14 15.29 7 20985 160211 64317529
Fulminant type 1 diabetes mellitus 30.72 15.29 12 20980 1068 64476672
Constipation 30.17 15.29 151 20841 229186 64248554
Pulmonary alveolar haemorrhage 29.81 15.29 25 20967 9713 64468027
Pneumonia aspiration 29.72 15.29 62 20930 59209 64418531
Haemoglobin decreased 29.71 15.29 134 20858 194929 64282811
Gastric ulcer haemorrhage 29.36 15.29 23 20969 8120 64469620
Cerebrovascular accident 28.86 15.29 5 20987 137578 64340162
Haemolytic anaemia 27.67 15.29 30 20962 16023 64461717
Tumour haemorrhage 27.45 15.29 16 20976 3477 64474263
Injection site dermatitis 27.32 15.29 5 20987 19 64477721
Hypersensitivity 27.25 15.29 15 20977 196437 64281303
Duodenal perforation 27.22 15.29 13 20979 1887 64475853
Weight increased 27.20 15.29 18 20974 213330 64264410
Paronychia 27.07 15.29 20 20972 6472 64471268
Arthropathy 26.25 15.29 4 20988 120963 64356777
Liver abscess 26.01 15.29 18 20974 5262 64472478
Anxiety 25.96 15.29 17 20975 202632 64275108
Gastroenteritis 25.08 15.29 39 20953 29672 64448068
Hypocalcaemia 24.94 15.29 47 20945 41706 64436034
Infective spondylitis 24.69 15.29 8 20984 412 64477328
Hepatocellular carcinoma 24.55 15.29 21 20971 8382 64469358
Malignant pleural effusion 24.41 15.29 14 20978 2953 64474787
Death 23.94 15.29 79 20913 482626 63995114
Eczema asteatotic 23.78 15.29 8 20984 464 64477276
Pneumothorax 23.51 15.29 34 20958 24264 64453476
Gamma-glutamyltransferase increased 23.45 15.29 50 20942 48460 64429280
Syncope 23.41 15.29 11 20981 157624 64320116
Blood lactate dehydrogenase increased 23.29 15.29 40 20952 33038 64444702
Chronic gastritis 23.26 15.29 14 20978 3226 64474514
Weight decreased 22.91 15.29 36 20956 285703 64192037
Enterocolitis viral 22.67 15.29 7 20985 308 64477432
Non-small cell lung cancer 22.52 15.29 16 20976 4874 64472866
Heart rate increased 22.02 15.29 3 20989 98672 64379068
Palmar-plantar erythrodysaesthesia syndrome 21.82 15.29 36 20956 28783 64448957
Shock haemorrhagic 21.61 15.29 27 20965 16764 64460976
Rash 21.57 15.29 236 20756 458313 64019427
Duodenal ulcer 21.50 15.29 25 20967 14410 64463330
Dyslalia 21.34 15.29 9 20983 976 64476764
Skin erosion 20.96 15.29 14 20978 3862 64473878
Small intestine ulcer 20.83 15.29 8 20984 680 64477060
Atypical femur fracture 20.79 15.29 15 20977 4683 64473057
Small intestinal perforation 20.76 15.29 12 20980 2568 64475172
Chest pain 20.61 15.29 28 20964 235952 64241788
Paraesthesia 20.57 15.29 9 20983 134513 64343227
Breast cancer 20.19 15.29 35 20957 29113 64448627
Melaena 20.15 15.29 50 20942 53498 64424242
Periodontitis 20.07 15.29 14 20978 4145 64473595
Hypothyroidism 19.90 15.29 42 20950 40415 64437325
Lymphoproliferative disorder 19.68 15.29 15 20977 5088 64472652
Blood urea increased 19.63 15.29 44 20948 44109 64433631
Tumour necrosis 19.45 15.29 10 20982 1699 64476041
Sudden hearing loss 19.45 15.29 10 20982 1700 64476040
Ascites 19.36 15.29 54 20938 61947 64415793
Cholangitis acute 19.16 15.29 9 20983 1259 64476481
Headache 19.14 15.29 98 20894 529369 63948371
Adrenocorticotropic hormone deficiency 19.10 15.29 8 20984 852 64476888
Arthralgia 18.88 15.29 77 20915 442183 64035557
Gastric cancer 18.51 15.29 16 20976 6477 64471263
Oculomucocutaneous syndrome 18.41 15.29 6 20986 315 64477425
Adrenal insufficiency 18.26 15.29 29 20963 22458 64455282
Diverticulum intestinal haemorrhagic 18.14 15.29 12 20980 3257 64474483
Subarachnoid haemorrhage 18.13 15.29 26 20966 18412 64459328
Pyelonephritis 17.94 15.29 25 20967 17241 64460499
Malignant ascites 17.66 15.29 8 20984 1030 64476710
Large intestine perforation 17.40 15.29 21 20971 12583 64465157
KL-6 increased 17.31 15.29 4 20988 56 64477684
Aortitis 17.21 15.29 8 20984 1093 64476647
Blood pressure decreased 16.87 15.29 64 20928 86135 64391605
Dermatitis acneiform 16.73 15.29 17 20975 8426 64469314
Lung neoplasm malignant 16.51 15.29 27 20965 21421 64456319
Blood creatine phosphokinase increased 16.35 15.29 49 20943 58509 64419231
Lupus nephritis 16.19 15.29 10 20982 2414 64475326
Rheumatoid arthritis 15.90 15.29 18 20974 164276 64313464
Colony stimulating factor therapy 15.64 15.29 6 20986 509 64477231
Pleurisy 15.38 15.29 17 20975 9274 64468466
Product use in unapproved indication 15.37 15.29 21 20971 176597 64301143
Hyperhidrosis 15.30 15.29 11 20981 124909 64352831

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M02AA31 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35493 anti-pyretic
CHEBI has role CHEBI:35544 cyclooxygenase inhibitors
CHEBI has role CHEBI:50266 Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.37 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 5 CHEMBL KEGG DRUG
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 5.19 CHEMBL KEGG DRUG

External reference:

IDSource
D08149 KEGG_DRUG
80382-23-6 SECONDARY_CAS_RN
C0065199 UMLSCUI
CHEBI:31786 CHEBI
CHEMBL19299 ChEMBL_ID
DB09212 DRUGBANK_ID
C040656 MESH_SUPPLEMENTAL_RECORD_UI
3965 PUBCHEM_CID
5410 INN_ID
3583H0GZAP UNII
28908 RXNORM
008162 NDDF
18991000122102 SNOMEDCT_US
CHEMBL66552 ChEMBL_ID

Pharmaceutical products:

None