All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

loxoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory agents, ibuprofen derivatives	1615	68767-14-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: loxoprofen sodium hydrate loxonin loxoprofen loxoprofen sodium sodium loxoprofen	Molecular weight: 246.31 Formula: C15H18O3 CLOGP: 1.97 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 54.37 ALOGS: -3.57 ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Jan. 23, 2006	PMDA	Lead Chemical Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Platelet count decreased	301.51	19.40	215	11261	106168	56174423
Interstitial lung disease	293.28	19.40	168	11308	56895	56223696
Hepatic function abnormal	222.15	19.40	118	11358	34440	56246151
Malignant neoplasm progression	168.47	19.40	131	11345	73456	56207135
Neutrophil count decreased	153.16	19.40	106	11370	49716	56230875
Osteonecrosis of jaw	129.20	19.40	82	11394	33276	56247315
White blood cell count decreased	127.09	19.40	142	11334	125848	56154743
Anaemia	120.65	19.40	204	11272	267307	56013284
Fatigue	106.47	19.40	17	11459	788535	55492056
Disseminated intravascular coagulation	100.74	19.40	56	11420	17829	56262762
Drug eruption	96.44	19.40	62	11414	25701	56254890
Drug ineffective	94.66	19.40	35	11441	918954	55361637
Pyrexia	75.38	19.40	221	11255	418552	55862039
Spinal compression fracture	73.62	19.40	41	11435	13093	56267498
Decreased appetite	73.17	19.40	147	11329	219084	56061507
Gastrointestinal perforation	70.51	19.40	26	11450	3173	56277418
Cerebral infarction	69.36	19.40	48	11428	22457	56258134
Erythema multiforme	65.22	19.40	34	11442	9520	56271071
Upper respiratory tract inflammation	61.56	19.40	22	11454	2455	56278136
Enterocolitis	59.39	19.40	29	11447	7075	56273516
Drug-induced liver injury	59.20	19.40	52	11424	34410	56246181
Renal impairment	55.37	19.40	75	11401	80638	56199953
Febrile neutropenia	54.85	19.40	86	11390	105459	56175132
Cardiac failure	54.38	19.40	75	11401	82018	56198573
Altered state of consciousness	52.62	19.40	41	11435	22980	56257611
Haemorrhage subcutaneous	51.65	19.40	20	11456	2790	56277801
Pneumonia bacterial	50.35	19.40	27	11449	8001	56272590
Iron deficiency anaemia	45.54	19.40	34	11442	17885	56262706
Liver disorder	44.61	19.40	50	11426	44320	56236271
Hypoalbuminaemia	43.37	19.40	27	11449	10572	56270019
Enteritis infectious	43.10	19.40	16	11460	1988	56278603
Drug intolerance	42.43	19.40	3	11473	264815	56015776
Femoral neck fracture	40.14	19.40	23	11453	7748	56272843
Ileus	39.03	19.40	28	11448	13854	56266737
Drug hypersensitivity	36.80	19.40	6	11470	275199	56005392
Colon cancer	35.74	19.40	23	11453	9538	56271053
Aspartate aminotransferase increased	34.44	19.40	61	11415	82541	56198050
Peripheral swelling	34.01	19.40	4	11472	234722	56045869
Pharyngitis	33.90	19.40	29	11447	18509	56262082
Pain	33.82	19.40	52	11424	663132	55617459
Cancer pain	33.68	19.40	15	11461	2971	56277620
Peritonitis	33.05	19.40	27	11449	16175	56264416
Swelling	32.57	19.40	5	11471	239766	56040825
Paronychia	32.13	19.40	17	11459	4901	56275690
Rheumatoid arthritis	30.93	19.40	20	11456	382584	55898007
Herpes zoster	30.30	19.40	55	11421	75834	56204757
Subarachnoid haemorrhage	29.88	19.40	22	11454	11325	56269266
Alanine aminotransferase increased	29.02	19.40	61	11415	93601	56186990
Ascites	28.99	19.40	37	11439	37507	56243084
Lymphocyte count decreased	28.96	19.40	32	11444	27907	56252684
Hypopituitarism	28.87	19.40	10	11466	1018	56279573
Fulminant type 1 diabetes mellitus	28.81	19.40	8	11468	390	56280201
Pulmonary alveolar haemorrhage	28.60	19.40	15	11461	4249	56276342
Eczema	27.18	19.40	30	11446	26123	56254468
Gastroenteritis	27.12	19.40	29	11447	24383	56256208
Stevens-Johnson syndrome	27.09	19.40	28	11448	22635	56257956
Purpura	27.08	19.40	20	11456	10342	56270249
Tumour haemorrhage	25.42	19.40	10	11466	1454	56279137
Asteatosis	25.34	19.40	5	11471	52	56280539
Aortitis	25.07	19.40	9	11467	1017	56279574
Weight increased	24.76	19.40	8	11468	229695	56050896
Duodenal ulcer haemorrhage	24.22	19.40	11	11465	2281	56278310
Haemoglobin decreased	24.17	19.40	71	11405	134066	56146525
Blood pressure decreased	23.82	19.40	43	11433	59007	56221584
Concomitant disease aggravated	23.70	19.40	17	11459	8409	56272182
Malignant pleural effusion	23.66	19.40	11	11465	2405	56278186
Atypical femur fracture	23.58	19.40	14	11462	5033	56275558
Hyperuricaemia	23.52	19.40	14	11462	5059	56275532
Lymphangiosis carcinomatosa	23.35	19.40	9	11467	1240	56279351
Enterocolitis viral	22.91	19.40	6	11470	234	56280357
Breast cancer	22.89	19.40	38	11438	48795	56231796
Blood bilirubin increased	22.86	19.40	31	11445	33323	56247268
Stomatitis	22.78	19.40	65	11411	120745	56159846
Hypersensitivity	22.69	19.40	12	11464	256396	56024195
Liver abscess	22.40	19.40	11	11465	2715	56277876
Pleural effusion	22.33	19.40	52	11424	85428	56195163
Melaena	22.03	19.40	28	11448	28262	56252329
Pneumocystis jirovecii pneumonia	21.72	19.40	21	11455	15680	56264911
Alopecia	21.52	19.40	17	11459	293441	55987150
Subacute hepatic failure	21.38	19.40	5	11471	121	56280470
Lymphoproliferative disorder	21.31	19.40	11	11465	3017	56277574
Delirium	21.17	19.40	34	11442	42483	56238108
Sinusitis	21.08	19.40	7	11469	197574	56083017
Asthenia	20.35	19.40	24	11452	342949	55937642

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Interstitial lung disease	413.31	17.21	254	10111	61149	31625830
Malignant neoplasm progression	224.36	17.21	194	10171	78804	31608175
Platelet count decreased	204.43	17.21	214	10151	110221	31576758
Hepatic function abnormal	194.90	17.21	137	10228	41085	31645894
White blood cell count decreased	118.09	17.21	144	10221	87254	31599725
Neutrophil count decreased	96.61	17.21	96	10269	46298	31640681
Liver disorder	86.17	17.21	74	10291	29633	31657346
Decreased appetite	76.47	17.21	160	10205	153057	31533922
Osteonecrosis of jaw	58.80	17.21	47	10318	17024	31669955
Stomatitis	56.44	17.21	67	10298	39371	31647608
Disseminated intravascular coagulation	53.20	17.21	48	10317	20489	31666490
Drug ineffective	53.12	17.21	32	10333	395541	31291438
Fatigue	52.66	17.21	22	10343	335184	31351795
Pyrexia	51.76	17.21	216	10149	303624	31383355
Renal impairment	45.10	17.21	92	10273	86257	31600722
Toxicity to various agents	44.71	17.21	4	10361	181483	31505496
Radiation pneumonitis	42.02	17.21	19	10346	2425	31684554
Asthenia	41.79	17.21	11	10354	224744	31462235
Cholangitis	41.07	17.21	28	10337	7958	31679021
Anaemia	40.41	17.21	157	10208	213365	31473614
Drug eruption	40.35	17.21	39	10326	18148	31668831
Drug-induced liver injury	39.22	17.21	44	10321	24319	31662660
Delirium	35.70	17.21	55	10310	41366	31645613
Altered state of consciousness	35.58	17.21	39	10326	21012	31665967
Cancer pain	35.21	17.21	17	10348	2516	31684463
Malaise	34.40	17.21	127	10238	168384	31518595
Gastrointestinal perforation	32.13	17.21	18	10347	3614	31683365
Upper respiratory tract inflammation	31.84	17.21	14	10351	1672	31685307
Gastric ulcer	31.74	17.21	31	10334	14603	31672376
Erythema multiforme	31.64	17.21	24	10341	8047	31678932
Aspartate aminotransferase increased	30.58	17.21	65	10300	62654	31624325
Gastric ulcer haemorrhage	28.83	17.21	19	10346	5104	31681875
Enterocolitis	27.13	17.21	21	10344	7253	31679726
C-reactive protein increased	26.76	17.21	53	10312	48597	31638382
Hyperuricaemia	26.72	17.21	21	10344	7417	31679562
Lymphangiosis carcinomatosa	26.07	17.21	10	10355	844	31686135
Blood bilirubin increased	25.29	17.21	43	10322	35093	31651886
Hypothyroidism	24.84	17.21	30	10335	17917	31669062
Pharyngitis	24.78	17.21	20	10345	7338	31679641
Pneumonia bacterial	24.58	17.21	23	10342	10273	31676706
Cerebral infarction	24.52	17.21	36	10329	25941	31661038
Death	24.38	17.21	51	10314	360518	31326461
Duodenal ulcer	23.67	17.21	22	10343	9742	31677237
Hypoalbuminaemia	23.24	17.21	23	10342	11005	31675974
Prescribed underdose	22.72	17.21	20	10345	8258	31678721
Product dose omission issue	21.95	17.21	4	10361	105582	31581397
Hypotension	21.68	17.21	21	10344	204597	31482382
Palmar-plantar erythrodysaesthesia syndrome	21.62	17.21	26	10339	15457	31671522
Alanine aminotransferase increased	21.21	17.21	63	10302	74593	31612386
Pneumonia aspiration	21.06	17.21	42	10323	38684	31648295
Blood lactate dehydrogenase increased	20.38	17.21	29	10336	20310	31666669
Adrenocorticotropic hormone deficiency	20.36	17.21	8	10357	720	31686259
Peritonitis	20.21	17.21	25	10340	15302	31671677
Anxiety	19.92	17.21	3	10362	91030	31595949
Infective spondylitis	19.84	17.21	6	10359	245	31686734
Rash	19.83	17.21	123	10242	201363	31485616
Haemorrhage subcutaneous	19.78	17.21	11	10354	2177	31684802
Eosinophil count increased	19.75	17.21	18	10347	7773	31679206
Pneumonia	19.62	17.21	181	10184	335131	31351848
Rhinitis allergic	19.59	17.21	12	10353	2842	31684137
Duodenal perforation	19.36	17.21	9	10356	1223	31685756
Adrenal insufficiency	18.91	17.21	22	10343	12637	31674342
Paralysis recurrent laryngeal nerve	18.44	17.21	4	10361	41	31686938
Colon cancer	18.22	17.21	18	10347	8595	31678384
Hepatocellular carcinoma	17.97	17.21	18	10347	8738	31678241
Constipation	17.82	17.21	84	10281	123907	31563072
Hypocalcaemia	17.29	17.21	28	10337	21950	31665029

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Interstitial lung disease	666.55	15.94	413	21965	104272	70801794
Platelet count decreased	491.88	15.94	424	21954	177798	70728268
Malignant neoplasm progression	394.34	15.94	318	22060	121421	70784645
Hepatic function abnormal	388.99	15.94	251	22127	67745	70838321
White blood cell count decreased	242.32	15.94	283	22095	169858	70736208
Neutrophil count decreased	228.26	15.94	198	22180	83358	70822708
Osteonecrosis of jaw	169.48	15.94	124	22254	40878	70865188
Fatigue	152.04	15.94	37	22341	824282	70081784
Disseminated intravascular coagulation	144.28	15.94	104	22274	33494	70872572
Anaemia	139.66	15.94	357	22021	403066	70503000
Decreased appetite	138.43	15.94	300	22078	304480	70601586
Drug ineffective	137.14	15.94	63	22315	939689	69966377
Drug eruption	118.81	15.94	99	22279	39397	70866669
Liver disorder	118.16	15.94	120	22258	61448	70844618
Pyrexia	113.09	15.94	433	21945	606519	70299547
Gastrointestinal perforation	95.47	15.94	43	22335	5638	70900428
Renal impairment	91.03	15.94	163	22215	143774	70762292
Erythema multiforme	86.88	15.94	58	22320	16506	70889560
Upper respiratory tract inflammation	86.43	15.94	36	22342	3906	70902160
Drug-induced liver injury	80.77	15.94	94	22284	56019	70850047
Spinal compression fracture	80.47	15.94	54	22324	15499	70890567
Enterocolitis	78.95	15.94	50	22328	13016	70893050
Cerebral infarction	77.39	15.94	81	22297	42928	70863138
Confusional state	76.70	15.94	3	22375	284395	70621671
Altered state of consciousness	74.93	15.94	77	22301	39945	70866121
Toxicity to various agents	72.51	15.94	16	22362	382156	70523910
Cancer pain	66.69	15.94	32	22346	4842	70901224
Asthenia	65.99	15.94	31	22347	457635	70448431
Pneumonia bacterial	65.74	15.94	49	22329	16592	70889474
Stomatitis	65.73	15.94	133	22245	128378	70777688
Haemorrhage subcutaneous	62.90	15.94	30	22348	4479	70901587
Hypoalbuminaemia	59.71	15.94	49	22329	19073	70886993
Joint swelling	58.48	15.94	6	22372	253205	70652861
Pharyngitis	57.04	15.94	49	22329	20302	70885764
Completed suicide	56.22	15.94	4	22374	227131	70678935
Febrile neutropenia	55.71	15.94	166	22212	204152	70701914
Aspartate aminotransferase increased	55.19	15.94	123	22255	126855	70779211
Product dose omission issue	53.34	15.94	4	22374	217464	70688602
Colon cancer	51.81	15.94	40	22338	14266	70891800
Drug hypersensitivity	51.79	15.94	10	22368	262449	70643617
Delirium	51.67	15.94	88	22290	74526	70831540
Drug intolerance	50.46	15.94	6	22372	225681	70680385
Hyperuricaemia	49.48	15.94	35	22343	10931	70895135
Peritonitis	48.36	15.94	50	22328	26109	70879957
Hypotension	47.51	15.94	35	22343	404346	70501720
Cardiac failure	47.34	15.94	125	22253	143416	70762650
Lymphangiosis carcinomatosa	47.27	15.94	19	22359	1882	70904184
Radiation pneumonitis	46.78	15.94	23	22355	3670	70902396
Peripheral swelling	46.69	15.94	9	22369	236554	70669512
Blood bilirubin increased	45.97	15.94	74	22304	59827	70846239
Cholangitis	45.60	15.94	34	22344	11515	70894551
Enteritis infectious	43.99	15.94	21	22357	3141	70902925
Gastric ulcer	42.01	15.94	51	22327	31739	70874327
Dyspnoea	40.82	15.94	117	22261	769943	70136123
Ileus	40.67	15.94	44	22334	24193	70881873
Alanine aminotransferase increased	40.34	15.94	120	22258	147360	70758706
Pneumonia	39.05	15.94	321	22057	595911	70310155
Femoral neck fracture	38.73	15.94	28	22350	9045	70897021
Hypopituitarism	38.64	15.94	19	22359	3031	70903035
Malaise	38.00	15.94	250	22128	432682	70473384
Swelling	37.57	15.94	7	22371	188532	70717534
Fulminant type 1 diabetes mellitus	36.40	15.94	14	22364	1233	70904833
Pain	35.95	15.94	92	22286	628724	70277342
Iron deficiency anaemia	35.46	15.94	40	22338	23032	70883034
Drug abuse	35.28	15.94	3	22375	147253	70758813
Herpes zoster	35.27	15.94	81	22297	85154	70820912
Pleural effusion	34.35	15.94	106	22272	132758	70773308
Therapeutic product effect decreased	34.03	15.94	3	22375	143015	70763051
Hypersensitivity	33.95	15.94	15	22363	229797	70676269
Arthropathy	33.50	15.94	4	22374	150053	70756013
Eczema	33.43	15.94	47	22331	33734	70872332
Prescribed underdose	32.74	15.94	37	22341	21348	70884718
Stevens-Johnson syndrome	32.66	15.94	48	22330	35859	70870207
Tumour haemorrhage	32.32	15.94	18	22360	3704	70902362
C-reactive protein increased	32.20	15.94	92	22286	110425	70795641
Rhinitis allergic	31.52	15.94	25	22353	9270	70896796
Adrenocorticotropic hormone deficiency	31.43	15.94	12	22366	1036	70905030
Constipation	31.41	15.94	160	22218	252278	70653788
Asteatosis	31.28	15.94	7	22371	87	70905979
Gastric ulcer haemorrhage	31.25	15.94	24	22354	8494	70897572
Weight increased	31.08	15.94	19	22359	242312	70663754
Pain in extremity	30.66	15.94	35	22343	328047	70578019
Renal disorder	30.60	15.94	48	22330	37961	70868105
Haemoglobin decreased	30.57	15.94	137	22241	205022	70701044
Gastroenteritis	30.25	15.94	43	22335	31170	70874896
Pneumonia aspiration	30.09	15.94	63	22315	62226	70843840
Pneumocystis jirovecii pneumonia	29.98	15.94	42	22336	30040	70876026
Malignant pleural effusion	29.51	15.94	16	22362	3123	70902943
Cerebrovascular accident	29.29	15.94	5	22373	143465	70762601
Pulmonary alveolar haemorrhage	29.12	15.94	25	22353	10344	70895722
Anxiety	28.64	15.94	17	22361	220313	70685753
Hypocalcaemia	28.56	15.94	51	22327	44808	70861258
Rheumatoid arthritis	28.51	15.94	30	22348	291775	70614291
Paronychia	28.32	15.94	21	22357	7053	70899013
Liver abscess	27.91	15.94	19	22359	5580	70900486
Duodenal ulcer	27.87	15.94	29	22349	15251	70890815
Gamma-glutamyltransferase increased	27.74	15.94	54	22324	50631	70855435
Injection site dermatitis	27.47	15.94	5	22373	19	70906047
Haemolytic anaemia	27.33	15.94	30	22348	16764	70889302
Duodenal perforation	26.72	15.94	13	22365	2027	70904039
Blood lactate dehydrogenase increased	26.41	15.94	43	22335	35084	70870982
Weight decreased	26.01	15.94	36	22342	310452	70595614
Pneumothorax	25.63	15.94	36	22342	25810	70880256
Small intestine ulcer	24.65	15.94	9	22369	686	70905380
Lymphocyte count decreased	24.58	15.94	47	22331	43492	70862574
Syncope	24.17	15.94	11	22367	165698	70740368
Infective spondylitis	23.81	15.94	8	22370	477	70905589
Hepatocellular carcinoma	23.50	15.94	22	22356	10186	70895880
Adrenal insufficiency	23.38	15.94	34	22344	25161	70880905
Skin erosion	23.34	15.94	15	22363	4001	70902065
Heart rate increased	23.27	15.94	3	22375	106145	70799921
Hypothyroidism	22.94	15.94	47	22331	45708	70860358
Palmar-plantar erythrodysaesthesia syndrome	22.70	15.94	37	22341	30210	70875856
Immune-mediated enterocolitis	22.55	15.94	14	22364	3517	70902549
Eczema asteatotic	22.47	15.94	8	22370	567	70905499
Chronic gastritis	22.26	15.94	14	22364	3599	70902467
Enterocolitis viral	21.93	15.94	7	22371	355	70905711
Cholangitis acute	21.64	15.94	10	22368	1390	70904676
Aortitis	21.57	15.94	10	22368	1401	70904665
Dyslalia	21.35	15.94	9	22369	1005	70905061
Death	21.16	15.94	86	22292	509975	70396091
Atypical femur fracture	20.79	15.94	15	22363	4828	70901238
Paraesthesia	20.70	15.94	10	22368	145527	70760539
Shock haemorrhagic	20.66	15.94	27	22351	18079	70887987
Melaena	20.55	15.94	51	22327	56304	70849762
Blood urea increased	20.52	15.94	45	22333	45864	70860202
Ascites	20.42	15.94	57	22321	67490	70838576
Concomitant disease aggravated	20.34	15.94	22	22356	12092	70893974
Diverticulum intestinal haemorrhagic	20.28	15.94	13	22365	3454	70902612
Chest pain	20.18	15.94	30	22348	251230	70654836
KL-6 increased	20.12	15.94	5	22373	100	70905966
Periodontitis	19.96	15.94	14	22364	4314	70901752
Breast cancer	19.91	15.94	37	22341	33512	70872554
Lymphoproliferative disorder	19.51	15.94	15	22363	5314	70900752
Tumour necrosis	19.43	15.94	10	22368	1757	70904309
Rash	19.41	15.94	246	22132	510316	70395750
Small intestinal perforation	19.40	15.94	12	22366	2997	70903069
Sinusitis	19.37	15.94	15	22363	169180	70736886
Non-small cell lung cancer	19.26	15.94	16	22362	6331	70899735
Sudden hearing loss	19.04	15.94	10	22368	1831	70904235
Wound	18.96	15.94	4	22374	98728	70807338
Pyelonephritis	18.92	15.94	26	22352	18263	70887803
Large intestine perforation	18.80	15.94	22	22356	13173	70892893
Oculomucocutaneous syndrome	18.48	15.94	6	22372	321	70905745
Duodenal ulcer haemorrhage	18.47	15.94	16	22362	6702	70899364
Blood pressure decreased	18.31	15.94	67	22311	91448	70814618
Dermatitis acneiform	18.18	15.94	18	22360	8927	70897139
Wheezing	17.71	15.94	4	22374	94166	70811900
Alopecia	17.65	15.94	22	22356	198468	70707598
Subarachnoid haemorrhage	17.63	15.94	26	22352	19478	70886588
Malignant ascites	17.44	15.94	8	22370	1093	70904973
Lupus nephritis	17.43	15.94	11	22367	2843	70903223
Product use in unapproved indication	17.42	15.94	24	22354	207454	70698612
Blood alkaline phosphatase increased	17.31	15.94	49	22329	58472	70847594
General physical health deterioration	17.24	15.94	30	22348	236001	70670065
Blood creatine phosphokinase increased	16.87	15.94	50	22328	61213	70844853
Pleurisy	16.81	15.94	18	22360	9781	70896285
Off label use	16.73	15.94	152	22226	742908	70163158
Colorectal cancer recurrent	16.05	15.94	4	22374	81	70905985

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M02AA31	MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents
CHEBI has role	CHEBI:35475	non-steroidal anti-inflammatory agent
CHEBI has role	CHEBI:35493	anti-pyretic
CHEBI has role	CHEBI:35544	cyclooxygenase inhibitors
CHEBI has role	CHEBI:50266	Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Rheumatoid arthritis	indication	69896004	DOID:7148

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.37	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN	INHIBITOR	IC50	5		CHEMBL	KEGG DRUG
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN	INHIBITOR	IC50	5.19		CHEMBL	KEGG DRUG

External reference:

ID	Source
D08149	KEGG_DRUG
C0065199	UMLSCUI
CHEBI:31786	CHEBI
CHEMBL19299	ChEMBL_ID
DB09212	DRUGBANK_ID
C040656	MESH_SUPPLEMENTAL_RECORD_UI
3965	PUBCHEM_CID
5410	INN_ID
80382-23-6	SECONDARY_CAS_RN
3583H0GZAP	UNII
28908	RXNORM
008162	NDDF
18991000122102	SNOMEDCT_US
CHEMBL66552	ChEMBL_ID

Pharmaceutical products:

None