loxoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 1615 68767-14-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • loxoprofen sodium hydrate
  • loxonin
  • loxoprofen
  • loxoprofen sodium
  • sodium loxoprofen
  • Molecular weight: 246.31
  • Formula: C15H18O3
  • CLOGP: 1.97
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 54.37
  • ALOGS: -3.57
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 23, 2006 PMDA Lead Chemical Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Platelet count decreased 301.51 19.40 215 11261 106168 56174423
Interstitial lung disease 293.28 19.40 168 11308 56895 56223696
Hepatic function abnormal 222.15 19.40 118 11358 34440 56246151
Malignant neoplasm progression 168.47 19.40 131 11345 73456 56207135
Neutrophil count decreased 153.16 19.40 106 11370 49716 56230875
Osteonecrosis of jaw 129.20 19.40 82 11394 33276 56247315
White blood cell count decreased 127.09 19.40 142 11334 125848 56154743
Anaemia 120.65 19.40 204 11272 267307 56013284
Fatigue 106.47 19.40 17 11459 788535 55492056
Disseminated intravascular coagulation 100.74 19.40 56 11420 17829 56262762
Drug eruption 96.44 19.40 62 11414 25701 56254890
Drug ineffective 94.66 19.40 35 11441 918954 55361637
Pyrexia 75.38 19.40 221 11255 418552 55862039
Spinal compression fracture 73.62 19.40 41 11435 13093 56267498
Decreased appetite 73.17 19.40 147 11329 219084 56061507
Gastrointestinal perforation 70.51 19.40 26 11450 3173 56277418
Cerebral infarction 69.36 19.40 48 11428 22457 56258134
Erythema multiforme 65.22 19.40 34 11442 9520 56271071
Upper respiratory tract inflammation 61.56 19.40 22 11454 2455 56278136
Enterocolitis 59.39 19.40 29 11447 7075 56273516
Drug-induced liver injury 59.20 19.40 52 11424 34410 56246181
Renal impairment 55.37 19.40 75 11401 80638 56199953
Febrile neutropenia 54.85 19.40 86 11390 105459 56175132
Cardiac failure 54.38 19.40 75 11401 82018 56198573
Altered state of consciousness 52.62 19.40 41 11435 22980 56257611
Haemorrhage subcutaneous 51.65 19.40 20 11456 2790 56277801
Pneumonia bacterial 50.35 19.40 27 11449 8001 56272590
Iron deficiency anaemia 45.54 19.40 34 11442 17885 56262706
Liver disorder 44.61 19.40 50 11426 44320 56236271
Hypoalbuminaemia 43.37 19.40 27 11449 10572 56270019
Enteritis infectious 43.10 19.40 16 11460 1988 56278603
Drug intolerance 42.43 19.40 3 11473 264815 56015776
Femoral neck fracture 40.14 19.40 23 11453 7748 56272843
Ileus 39.03 19.40 28 11448 13854 56266737
Drug hypersensitivity 36.80 19.40 6 11470 275199 56005392
Colon cancer 35.74 19.40 23 11453 9538 56271053
Aspartate aminotransferase increased 34.44 19.40 61 11415 82541 56198050
Peripheral swelling 34.01 19.40 4 11472 234722 56045869
Pharyngitis 33.90 19.40 29 11447 18509 56262082
Pain 33.82 19.40 52 11424 663132 55617459
Cancer pain 33.68 19.40 15 11461 2971 56277620
Peritonitis 33.05 19.40 27 11449 16175 56264416
Swelling 32.57 19.40 5 11471 239766 56040825
Paronychia 32.13 19.40 17 11459 4901 56275690
Rheumatoid arthritis 30.93 19.40 20 11456 382584 55898007
Herpes zoster 30.30 19.40 55 11421 75834 56204757
Subarachnoid haemorrhage 29.88 19.40 22 11454 11325 56269266
Alanine aminotransferase increased 29.02 19.40 61 11415 93601 56186990
Ascites 28.99 19.40 37 11439 37507 56243084
Lymphocyte count decreased 28.96 19.40 32 11444 27907 56252684
Hypopituitarism 28.87 19.40 10 11466 1018 56279573
Fulminant type 1 diabetes mellitus 28.81 19.40 8 11468 390 56280201
Pulmonary alveolar haemorrhage 28.60 19.40 15 11461 4249 56276342
Eczema 27.18 19.40 30 11446 26123 56254468
Gastroenteritis 27.12 19.40 29 11447 24383 56256208
Stevens-Johnson syndrome 27.09 19.40 28 11448 22635 56257956
Purpura 27.08 19.40 20 11456 10342 56270249
Tumour haemorrhage 25.42 19.40 10 11466 1454 56279137
Asteatosis 25.34 19.40 5 11471 52 56280539
Aortitis 25.07 19.40 9 11467 1017 56279574
Weight increased 24.76 19.40 8 11468 229695 56050896
Duodenal ulcer haemorrhage 24.22 19.40 11 11465 2281 56278310
Haemoglobin decreased 24.17 19.40 71 11405 134066 56146525
Blood pressure decreased 23.82 19.40 43 11433 59007 56221584
Concomitant disease aggravated 23.70 19.40 17 11459 8409 56272182
Malignant pleural effusion 23.66 19.40 11 11465 2405 56278186
Atypical femur fracture 23.58 19.40 14 11462 5033 56275558
Hyperuricaemia 23.52 19.40 14 11462 5059 56275532
Lymphangiosis carcinomatosa 23.35 19.40 9 11467 1240 56279351
Enterocolitis viral 22.91 19.40 6 11470 234 56280357
Breast cancer 22.89 19.40 38 11438 48795 56231796
Blood bilirubin increased 22.86 19.40 31 11445 33323 56247268
Stomatitis 22.78 19.40 65 11411 120745 56159846
Hypersensitivity 22.69 19.40 12 11464 256396 56024195
Liver abscess 22.40 19.40 11 11465 2715 56277876
Pleural effusion 22.33 19.40 52 11424 85428 56195163
Melaena 22.03 19.40 28 11448 28262 56252329
Pneumocystis jirovecii pneumonia 21.72 19.40 21 11455 15680 56264911
Alopecia 21.52 19.40 17 11459 293441 55987150
Subacute hepatic failure 21.38 19.40 5 11471 121 56280470
Lymphoproliferative disorder 21.31 19.40 11 11465 3017 56277574
Delirium 21.17 19.40 34 11442 42483 56238108
Sinusitis 21.08 19.40 7 11469 197574 56083017
Asthenia 20.35 19.40 24 11452 342949 55937642

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 413.31 17.21 254 10111 61149 31625830
Malignant neoplasm progression 224.36 17.21 194 10171 78804 31608175
Platelet count decreased 204.43 17.21 214 10151 110221 31576758
Hepatic function abnormal 194.90 17.21 137 10228 41085 31645894
White blood cell count decreased 118.09 17.21 144 10221 87254 31599725
Neutrophil count decreased 96.61 17.21 96 10269 46298 31640681
Liver disorder 86.17 17.21 74 10291 29633 31657346
Decreased appetite 76.47 17.21 160 10205 153057 31533922
Osteonecrosis of jaw 58.80 17.21 47 10318 17024 31669955
Stomatitis 56.44 17.21 67 10298 39371 31647608
Disseminated intravascular coagulation 53.20 17.21 48 10317 20489 31666490
Drug ineffective 53.12 17.21 32 10333 395541 31291438
Fatigue 52.66 17.21 22 10343 335184 31351795
Pyrexia 51.76 17.21 216 10149 303624 31383355
Renal impairment 45.10 17.21 92 10273 86257 31600722
Toxicity to various agents 44.71 17.21 4 10361 181483 31505496
Radiation pneumonitis 42.02 17.21 19 10346 2425 31684554
Asthenia 41.79 17.21 11 10354 224744 31462235
Cholangitis 41.07 17.21 28 10337 7958 31679021
Anaemia 40.41 17.21 157 10208 213365 31473614
Drug eruption 40.35 17.21 39 10326 18148 31668831
Drug-induced liver injury 39.22 17.21 44 10321 24319 31662660
Delirium 35.70 17.21 55 10310 41366 31645613
Altered state of consciousness 35.58 17.21 39 10326 21012 31665967
Cancer pain 35.21 17.21 17 10348 2516 31684463
Malaise 34.40 17.21 127 10238 168384 31518595
Gastrointestinal perforation 32.13 17.21 18 10347 3614 31683365
Upper respiratory tract inflammation 31.84 17.21 14 10351 1672 31685307
Gastric ulcer 31.74 17.21 31 10334 14603 31672376
Erythema multiforme 31.64 17.21 24 10341 8047 31678932
Aspartate aminotransferase increased 30.58 17.21 65 10300 62654 31624325
Gastric ulcer haemorrhage 28.83 17.21 19 10346 5104 31681875
Enterocolitis 27.13 17.21 21 10344 7253 31679726
C-reactive protein increased 26.76 17.21 53 10312 48597 31638382
Hyperuricaemia 26.72 17.21 21 10344 7417 31679562
Lymphangiosis carcinomatosa 26.07 17.21 10 10355 844 31686135
Blood bilirubin increased 25.29 17.21 43 10322 35093 31651886
Hypothyroidism 24.84 17.21 30 10335 17917 31669062
Pharyngitis 24.78 17.21 20 10345 7338 31679641
Pneumonia bacterial 24.58 17.21 23 10342 10273 31676706
Cerebral infarction 24.52 17.21 36 10329 25941 31661038
Death 24.38 17.21 51 10314 360518 31326461
Duodenal ulcer 23.67 17.21 22 10343 9742 31677237
Hypoalbuminaemia 23.24 17.21 23 10342 11005 31675974
Prescribed underdose 22.72 17.21 20 10345 8258 31678721
Product dose omission issue 21.95 17.21 4 10361 105582 31581397
Hypotension 21.68 17.21 21 10344 204597 31482382
Palmar-plantar erythrodysaesthesia syndrome 21.62 17.21 26 10339 15457 31671522
Alanine aminotransferase increased 21.21 17.21 63 10302 74593 31612386
Pneumonia aspiration 21.06 17.21 42 10323 38684 31648295
Blood lactate dehydrogenase increased 20.38 17.21 29 10336 20310 31666669
Adrenocorticotropic hormone deficiency 20.36 17.21 8 10357 720 31686259
Peritonitis 20.21 17.21 25 10340 15302 31671677
Anxiety 19.92 17.21 3 10362 91030 31595949
Infective spondylitis 19.84 17.21 6 10359 245 31686734
Rash 19.83 17.21 123 10242 201363 31485616
Haemorrhage subcutaneous 19.78 17.21 11 10354 2177 31684802
Eosinophil count increased 19.75 17.21 18 10347 7773 31679206
Pneumonia 19.62 17.21 181 10184 335131 31351848
Rhinitis allergic 19.59 17.21 12 10353 2842 31684137
Duodenal perforation 19.36 17.21 9 10356 1223 31685756
Adrenal insufficiency 18.91 17.21 22 10343 12637 31674342
Paralysis recurrent laryngeal nerve 18.44 17.21 4 10361 41 31686938
Colon cancer 18.22 17.21 18 10347 8595 31678384
Hepatocellular carcinoma 17.97 17.21 18 10347 8738 31678241
Constipation 17.82 17.21 84 10281 123907 31563072
Hypocalcaemia 17.29 17.21 28 10337 21950 31665029

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 666.55 15.94 413 21965 104272 70801794
Platelet count decreased 491.88 15.94 424 21954 177798 70728268
Malignant neoplasm progression 394.34 15.94 318 22060 121421 70784645
Hepatic function abnormal 388.99 15.94 251 22127 67745 70838321
White blood cell count decreased 242.32 15.94 283 22095 169858 70736208
Neutrophil count decreased 228.26 15.94 198 22180 83358 70822708
Osteonecrosis of jaw 169.48 15.94 124 22254 40878 70865188
Fatigue 152.04 15.94 37 22341 824282 70081784
Disseminated intravascular coagulation 144.28 15.94 104 22274 33494 70872572
Anaemia 139.66 15.94 357 22021 403066 70503000
Decreased appetite 138.43 15.94 300 22078 304480 70601586
Drug ineffective 137.14 15.94 63 22315 939689 69966377
Drug eruption 118.81 15.94 99 22279 39397 70866669
Liver disorder 118.16 15.94 120 22258 61448 70844618
Pyrexia 113.09 15.94 433 21945 606519 70299547
Gastrointestinal perforation 95.47 15.94 43 22335 5638 70900428
Renal impairment 91.03 15.94 163 22215 143774 70762292
Erythema multiforme 86.88 15.94 58 22320 16506 70889560
Upper respiratory tract inflammation 86.43 15.94 36 22342 3906 70902160
Drug-induced liver injury 80.77 15.94 94 22284 56019 70850047
Spinal compression fracture 80.47 15.94 54 22324 15499 70890567
Enterocolitis 78.95 15.94 50 22328 13016 70893050
Cerebral infarction 77.39 15.94 81 22297 42928 70863138
Confusional state 76.70 15.94 3 22375 284395 70621671
Altered state of consciousness 74.93 15.94 77 22301 39945 70866121
Toxicity to various agents 72.51 15.94 16 22362 382156 70523910
Cancer pain 66.69 15.94 32 22346 4842 70901224
Asthenia 65.99 15.94 31 22347 457635 70448431
Pneumonia bacterial 65.74 15.94 49 22329 16592 70889474
Stomatitis 65.73 15.94 133 22245 128378 70777688
Haemorrhage subcutaneous 62.90 15.94 30 22348 4479 70901587
Hypoalbuminaemia 59.71 15.94 49 22329 19073 70886993
Joint swelling 58.48 15.94 6 22372 253205 70652861
Pharyngitis 57.04 15.94 49 22329 20302 70885764
Completed suicide 56.22 15.94 4 22374 227131 70678935
Febrile neutropenia 55.71 15.94 166 22212 204152 70701914
Aspartate aminotransferase increased 55.19 15.94 123 22255 126855 70779211
Product dose omission issue 53.34 15.94 4 22374 217464 70688602
Colon cancer 51.81 15.94 40 22338 14266 70891800
Drug hypersensitivity 51.79 15.94 10 22368 262449 70643617
Delirium 51.67 15.94 88 22290 74526 70831540
Drug intolerance 50.46 15.94 6 22372 225681 70680385
Hyperuricaemia 49.48 15.94 35 22343 10931 70895135
Peritonitis 48.36 15.94 50 22328 26109 70879957
Hypotension 47.51 15.94 35 22343 404346 70501720
Cardiac failure 47.34 15.94 125 22253 143416 70762650
Lymphangiosis carcinomatosa 47.27 15.94 19 22359 1882 70904184
Radiation pneumonitis 46.78 15.94 23 22355 3670 70902396
Peripheral swelling 46.69 15.94 9 22369 236554 70669512
Blood bilirubin increased 45.97 15.94 74 22304 59827 70846239
Cholangitis 45.60 15.94 34 22344 11515 70894551
Enteritis infectious 43.99 15.94 21 22357 3141 70902925
Gastric ulcer 42.01 15.94 51 22327 31739 70874327
Dyspnoea 40.82 15.94 117 22261 769943 70136123
Ileus 40.67 15.94 44 22334 24193 70881873
Alanine aminotransferase increased 40.34 15.94 120 22258 147360 70758706
Pneumonia 39.05 15.94 321 22057 595911 70310155
Femoral neck fracture 38.73 15.94 28 22350 9045 70897021
Hypopituitarism 38.64 15.94 19 22359 3031 70903035
Malaise 38.00 15.94 250 22128 432682 70473384
Swelling 37.57 15.94 7 22371 188532 70717534
Fulminant type 1 diabetes mellitus 36.40 15.94 14 22364 1233 70904833
Pain 35.95 15.94 92 22286 628724 70277342
Iron deficiency anaemia 35.46 15.94 40 22338 23032 70883034
Drug abuse 35.28 15.94 3 22375 147253 70758813
Herpes zoster 35.27 15.94 81 22297 85154 70820912
Pleural effusion 34.35 15.94 106 22272 132758 70773308
Therapeutic product effect decreased 34.03 15.94 3 22375 143015 70763051
Hypersensitivity 33.95 15.94 15 22363 229797 70676269
Arthropathy 33.50 15.94 4 22374 150053 70756013
Eczema 33.43 15.94 47 22331 33734 70872332
Prescribed underdose 32.74 15.94 37 22341 21348 70884718
Stevens-Johnson syndrome 32.66 15.94 48 22330 35859 70870207
Tumour haemorrhage 32.32 15.94 18 22360 3704 70902362
C-reactive protein increased 32.20 15.94 92 22286 110425 70795641
Rhinitis allergic 31.52 15.94 25 22353 9270 70896796
Adrenocorticotropic hormone deficiency 31.43 15.94 12 22366 1036 70905030
Constipation 31.41 15.94 160 22218 252278 70653788
Asteatosis 31.28 15.94 7 22371 87 70905979
Gastric ulcer haemorrhage 31.25 15.94 24 22354 8494 70897572
Weight increased 31.08 15.94 19 22359 242312 70663754
Pain in extremity 30.66 15.94 35 22343 328047 70578019
Renal disorder 30.60 15.94 48 22330 37961 70868105
Haemoglobin decreased 30.57 15.94 137 22241 205022 70701044
Gastroenteritis 30.25 15.94 43 22335 31170 70874896
Pneumonia aspiration 30.09 15.94 63 22315 62226 70843840
Pneumocystis jirovecii pneumonia 29.98 15.94 42 22336 30040 70876026
Malignant pleural effusion 29.51 15.94 16 22362 3123 70902943
Cerebrovascular accident 29.29 15.94 5 22373 143465 70762601
Pulmonary alveolar haemorrhage 29.12 15.94 25 22353 10344 70895722
Anxiety 28.64 15.94 17 22361 220313 70685753
Hypocalcaemia 28.56 15.94 51 22327 44808 70861258
Rheumatoid arthritis 28.51 15.94 30 22348 291775 70614291
Paronychia 28.32 15.94 21 22357 7053 70899013
Liver abscess 27.91 15.94 19 22359 5580 70900486
Duodenal ulcer 27.87 15.94 29 22349 15251 70890815
Gamma-glutamyltransferase increased 27.74 15.94 54 22324 50631 70855435
Injection site dermatitis 27.47 15.94 5 22373 19 70906047
Haemolytic anaemia 27.33 15.94 30 22348 16764 70889302
Duodenal perforation 26.72 15.94 13 22365 2027 70904039
Blood lactate dehydrogenase increased 26.41 15.94 43 22335 35084 70870982
Weight decreased 26.01 15.94 36 22342 310452 70595614
Pneumothorax 25.63 15.94 36 22342 25810 70880256
Small intestine ulcer 24.65 15.94 9 22369 686 70905380
Lymphocyte count decreased 24.58 15.94 47 22331 43492 70862574
Syncope 24.17 15.94 11 22367 165698 70740368
Infective spondylitis 23.81 15.94 8 22370 477 70905589
Hepatocellular carcinoma 23.50 15.94 22 22356 10186 70895880
Adrenal insufficiency 23.38 15.94 34 22344 25161 70880905
Skin erosion 23.34 15.94 15 22363 4001 70902065
Heart rate increased 23.27 15.94 3 22375 106145 70799921
Hypothyroidism 22.94 15.94 47 22331 45708 70860358
Palmar-plantar erythrodysaesthesia syndrome 22.70 15.94 37 22341 30210 70875856
Immune-mediated enterocolitis 22.55 15.94 14 22364 3517 70902549
Eczema asteatotic 22.47 15.94 8 22370 567 70905499
Chronic gastritis 22.26 15.94 14 22364 3599 70902467
Enterocolitis viral 21.93 15.94 7 22371 355 70905711
Cholangitis acute 21.64 15.94 10 22368 1390 70904676
Aortitis 21.57 15.94 10 22368 1401 70904665
Dyslalia 21.35 15.94 9 22369 1005 70905061
Death 21.16 15.94 86 22292 509975 70396091
Atypical femur fracture 20.79 15.94 15 22363 4828 70901238
Paraesthesia 20.70 15.94 10 22368 145527 70760539
Shock haemorrhagic 20.66 15.94 27 22351 18079 70887987
Melaena 20.55 15.94 51 22327 56304 70849762
Blood urea increased 20.52 15.94 45 22333 45864 70860202
Ascites 20.42 15.94 57 22321 67490 70838576
Concomitant disease aggravated 20.34 15.94 22 22356 12092 70893974
Diverticulum intestinal haemorrhagic 20.28 15.94 13 22365 3454 70902612
Chest pain 20.18 15.94 30 22348 251230 70654836
KL-6 increased 20.12 15.94 5 22373 100 70905966
Periodontitis 19.96 15.94 14 22364 4314 70901752
Breast cancer 19.91 15.94 37 22341 33512 70872554
Lymphoproliferative disorder 19.51 15.94 15 22363 5314 70900752
Tumour necrosis 19.43 15.94 10 22368 1757 70904309
Rash 19.41 15.94 246 22132 510316 70395750
Small intestinal perforation 19.40 15.94 12 22366 2997 70903069
Sinusitis 19.37 15.94 15 22363 169180 70736886
Non-small cell lung cancer 19.26 15.94 16 22362 6331 70899735
Sudden hearing loss 19.04 15.94 10 22368 1831 70904235
Wound 18.96 15.94 4 22374 98728 70807338
Pyelonephritis 18.92 15.94 26 22352 18263 70887803
Large intestine perforation 18.80 15.94 22 22356 13173 70892893
Oculomucocutaneous syndrome 18.48 15.94 6 22372 321 70905745
Duodenal ulcer haemorrhage 18.47 15.94 16 22362 6702 70899364
Blood pressure decreased 18.31 15.94 67 22311 91448 70814618
Dermatitis acneiform 18.18 15.94 18 22360 8927 70897139
Wheezing 17.71 15.94 4 22374 94166 70811900
Alopecia 17.65 15.94 22 22356 198468 70707598
Subarachnoid haemorrhage 17.63 15.94 26 22352 19478 70886588
Malignant ascites 17.44 15.94 8 22370 1093 70904973
Lupus nephritis 17.43 15.94 11 22367 2843 70903223
Product use in unapproved indication 17.42 15.94 24 22354 207454 70698612
Blood alkaline phosphatase increased 17.31 15.94 49 22329 58472 70847594
General physical health deterioration 17.24 15.94 30 22348 236001 70670065
Blood creatine phosphokinase increased 16.87 15.94 50 22328 61213 70844853
Pleurisy 16.81 15.94 18 22360 9781 70896285
Off label use 16.73 15.94 152 22226 742908 70163158
Colorectal cancer recurrent 16.05 15.94 4 22374 81 70905985

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M02AA31 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35493 anti-pyretic
CHEBI has role CHEBI:35544 cyclooxygenase inhibitors
CHEBI has role CHEBI:50266 Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.37 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 5 CHEMBL KEGG DRUG
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 5.19 CHEMBL KEGG DRUG

External reference:

IDSource
D08149 KEGG_DRUG
C0065199 UMLSCUI
CHEBI:31786 CHEBI
CHEMBL19299 ChEMBL_ID
DB09212 DRUGBANK_ID
C040656 MESH_SUPPLEMENTAL_RECORD_UI
3965 PUBCHEM_CID
5410 INN_ID
80382-23-6 SECONDARY_CAS_RN
3583H0GZAP UNII
28908 RXNORM
008162 NDDF
18991000122102 SNOMEDCT_US
CHEMBL66552 ChEMBL_ID

Pharmaceutical products:

None