Stem definition | Drug id | CAS RN |
---|---|---|
anti-inflammatory agents, ibuprofen derivatives | 1615 | 68767-14-6 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 23, 2006 | PMDA | Lead Chemical Co., Ltd. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Platelet count decreased | 301.51 | 19.40 | 215 | 11261 | 106168 | 56174423 |
Interstitial lung disease | 293.28 | 19.40 | 168 | 11308 | 56895 | 56223696 |
Hepatic function abnormal | 222.15 | 19.40 | 118 | 11358 | 34440 | 56246151 |
Malignant neoplasm progression | 168.47 | 19.40 | 131 | 11345 | 73456 | 56207135 |
Neutrophil count decreased | 153.16 | 19.40 | 106 | 11370 | 49716 | 56230875 |
Osteonecrosis of jaw | 129.20 | 19.40 | 82 | 11394 | 33276 | 56247315 |
White blood cell count decreased | 127.09 | 19.40 | 142 | 11334 | 125848 | 56154743 |
Anaemia | 120.65 | 19.40 | 204 | 11272 | 267307 | 56013284 |
Fatigue | 106.47 | 19.40 | 17 | 11459 | 788535 | 55492056 |
Disseminated intravascular coagulation | 100.74 | 19.40 | 56 | 11420 | 17829 | 56262762 |
Drug eruption | 96.44 | 19.40 | 62 | 11414 | 25701 | 56254890 |
Drug ineffective | 94.66 | 19.40 | 35 | 11441 | 918954 | 55361637 |
Pyrexia | 75.38 | 19.40 | 221 | 11255 | 418552 | 55862039 |
Spinal compression fracture | 73.62 | 19.40 | 41 | 11435 | 13093 | 56267498 |
Decreased appetite | 73.17 | 19.40 | 147 | 11329 | 219084 | 56061507 |
Gastrointestinal perforation | 70.51 | 19.40 | 26 | 11450 | 3173 | 56277418 |
Cerebral infarction | 69.36 | 19.40 | 48 | 11428 | 22457 | 56258134 |
Erythema multiforme | 65.22 | 19.40 | 34 | 11442 | 9520 | 56271071 |
Upper respiratory tract inflammation | 61.56 | 19.40 | 22 | 11454 | 2455 | 56278136 |
Enterocolitis | 59.39 | 19.40 | 29 | 11447 | 7075 | 56273516 |
Drug-induced liver injury | 59.20 | 19.40 | 52 | 11424 | 34410 | 56246181 |
Renal impairment | 55.37 | 19.40 | 75 | 11401 | 80638 | 56199953 |
Febrile neutropenia | 54.85 | 19.40 | 86 | 11390 | 105459 | 56175132 |
Cardiac failure | 54.38 | 19.40 | 75 | 11401 | 82018 | 56198573 |
Altered state of consciousness | 52.62 | 19.40 | 41 | 11435 | 22980 | 56257611 |
Haemorrhage subcutaneous | 51.65 | 19.40 | 20 | 11456 | 2790 | 56277801 |
Pneumonia bacterial | 50.35 | 19.40 | 27 | 11449 | 8001 | 56272590 |
Iron deficiency anaemia | 45.54 | 19.40 | 34 | 11442 | 17885 | 56262706 |
Liver disorder | 44.61 | 19.40 | 50 | 11426 | 44320 | 56236271 |
Hypoalbuminaemia | 43.37 | 19.40 | 27 | 11449 | 10572 | 56270019 |
Enteritis infectious | 43.10 | 19.40 | 16 | 11460 | 1988 | 56278603 |
Drug intolerance | 42.43 | 19.40 | 3 | 11473 | 264815 | 56015776 |
Femoral neck fracture | 40.14 | 19.40 | 23 | 11453 | 7748 | 56272843 |
Ileus | 39.03 | 19.40 | 28 | 11448 | 13854 | 56266737 |
Drug hypersensitivity | 36.80 | 19.40 | 6 | 11470 | 275199 | 56005392 |
Colon cancer | 35.74 | 19.40 | 23 | 11453 | 9538 | 56271053 |
Aspartate aminotransferase increased | 34.44 | 19.40 | 61 | 11415 | 82541 | 56198050 |
Peripheral swelling | 34.01 | 19.40 | 4 | 11472 | 234722 | 56045869 |
Pharyngitis | 33.90 | 19.40 | 29 | 11447 | 18509 | 56262082 |
Pain | 33.82 | 19.40 | 52 | 11424 | 663132 | 55617459 |
Cancer pain | 33.68 | 19.40 | 15 | 11461 | 2971 | 56277620 |
Peritonitis | 33.05 | 19.40 | 27 | 11449 | 16175 | 56264416 |
Swelling | 32.57 | 19.40 | 5 | 11471 | 239766 | 56040825 |
Paronychia | 32.13 | 19.40 | 17 | 11459 | 4901 | 56275690 |
Rheumatoid arthritis | 30.93 | 19.40 | 20 | 11456 | 382584 | 55898007 |
Herpes zoster | 30.30 | 19.40 | 55 | 11421 | 75834 | 56204757 |
Subarachnoid haemorrhage | 29.88 | 19.40 | 22 | 11454 | 11325 | 56269266 |
Alanine aminotransferase increased | 29.02 | 19.40 | 61 | 11415 | 93601 | 56186990 |
Ascites | 28.99 | 19.40 | 37 | 11439 | 37507 | 56243084 |
Lymphocyte count decreased | 28.96 | 19.40 | 32 | 11444 | 27907 | 56252684 |
Hypopituitarism | 28.87 | 19.40 | 10 | 11466 | 1018 | 56279573 |
Fulminant type 1 diabetes mellitus | 28.81 | 19.40 | 8 | 11468 | 390 | 56280201 |
Pulmonary alveolar haemorrhage | 28.60 | 19.40 | 15 | 11461 | 4249 | 56276342 |
Eczema | 27.18 | 19.40 | 30 | 11446 | 26123 | 56254468 |
Gastroenteritis | 27.12 | 19.40 | 29 | 11447 | 24383 | 56256208 |
Stevens-Johnson syndrome | 27.09 | 19.40 | 28 | 11448 | 22635 | 56257956 |
Purpura | 27.08 | 19.40 | 20 | 11456 | 10342 | 56270249 |
Tumour haemorrhage | 25.42 | 19.40 | 10 | 11466 | 1454 | 56279137 |
Asteatosis | 25.34 | 19.40 | 5 | 11471 | 52 | 56280539 |
Aortitis | 25.07 | 19.40 | 9 | 11467 | 1017 | 56279574 |
Weight increased | 24.76 | 19.40 | 8 | 11468 | 229695 | 56050896 |
Duodenal ulcer haemorrhage | 24.22 | 19.40 | 11 | 11465 | 2281 | 56278310 |
Haemoglobin decreased | 24.17 | 19.40 | 71 | 11405 | 134066 | 56146525 |
Blood pressure decreased | 23.82 | 19.40 | 43 | 11433 | 59007 | 56221584 |
Concomitant disease aggravated | 23.70 | 19.40 | 17 | 11459 | 8409 | 56272182 |
Malignant pleural effusion | 23.66 | 19.40 | 11 | 11465 | 2405 | 56278186 |
Atypical femur fracture | 23.58 | 19.40 | 14 | 11462 | 5033 | 56275558 |
Hyperuricaemia | 23.52 | 19.40 | 14 | 11462 | 5059 | 56275532 |
Lymphangiosis carcinomatosa | 23.35 | 19.40 | 9 | 11467 | 1240 | 56279351 |
Enterocolitis viral | 22.91 | 19.40 | 6 | 11470 | 234 | 56280357 |
Breast cancer | 22.89 | 19.40 | 38 | 11438 | 48795 | 56231796 |
Blood bilirubin increased | 22.86 | 19.40 | 31 | 11445 | 33323 | 56247268 |
Stomatitis | 22.78 | 19.40 | 65 | 11411 | 120745 | 56159846 |
Hypersensitivity | 22.69 | 19.40 | 12 | 11464 | 256396 | 56024195 |
Liver abscess | 22.40 | 19.40 | 11 | 11465 | 2715 | 56277876 |
Pleural effusion | 22.33 | 19.40 | 52 | 11424 | 85428 | 56195163 |
Melaena | 22.03 | 19.40 | 28 | 11448 | 28262 | 56252329 |
Pneumocystis jirovecii pneumonia | 21.72 | 19.40 | 21 | 11455 | 15680 | 56264911 |
Alopecia | 21.52 | 19.40 | 17 | 11459 | 293441 | 55987150 |
Subacute hepatic failure | 21.38 | 19.40 | 5 | 11471 | 121 | 56280470 |
Lymphoproliferative disorder | 21.31 | 19.40 | 11 | 11465 | 3017 | 56277574 |
Delirium | 21.17 | 19.40 | 34 | 11442 | 42483 | 56238108 |
Sinusitis | 21.08 | 19.40 | 7 | 11469 | 197574 | 56083017 |
Asthenia | 20.35 | 19.40 | 24 | 11452 | 342949 | 55937642 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Interstitial lung disease | 413.31 | 17.21 | 254 | 10111 | 61149 | 31625830 |
Malignant neoplasm progression | 224.36 | 17.21 | 194 | 10171 | 78804 | 31608175 |
Platelet count decreased | 204.43 | 17.21 | 214 | 10151 | 110221 | 31576758 |
Hepatic function abnormal | 194.90 | 17.21 | 137 | 10228 | 41085 | 31645894 |
White blood cell count decreased | 118.09 | 17.21 | 144 | 10221 | 87254 | 31599725 |
Neutrophil count decreased | 96.61 | 17.21 | 96 | 10269 | 46298 | 31640681 |
Liver disorder | 86.17 | 17.21 | 74 | 10291 | 29633 | 31657346 |
Decreased appetite | 76.47 | 17.21 | 160 | 10205 | 153057 | 31533922 |
Osteonecrosis of jaw | 58.80 | 17.21 | 47 | 10318 | 17024 | 31669955 |
Stomatitis | 56.44 | 17.21 | 67 | 10298 | 39371 | 31647608 |
Disseminated intravascular coagulation | 53.20 | 17.21 | 48 | 10317 | 20489 | 31666490 |
Drug ineffective | 53.12 | 17.21 | 32 | 10333 | 395541 | 31291438 |
Fatigue | 52.66 | 17.21 | 22 | 10343 | 335184 | 31351795 |
Pyrexia | 51.76 | 17.21 | 216 | 10149 | 303624 | 31383355 |
Renal impairment | 45.10 | 17.21 | 92 | 10273 | 86257 | 31600722 |
Toxicity to various agents | 44.71 | 17.21 | 4 | 10361 | 181483 | 31505496 |
Radiation pneumonitis | 42.02 | 17.21 | 19 | 10346 | 2425 | 31684554 |
Asthenia | 41.79 | 17.21 | 11 | 10354 | 224744 | 31462235 |
Cholangitis | 41.07 | 17.21 | 28 | 10337 | 7958 | 31679021 |
Anaemia | 40.41 | 17.21 | 157 | 10208 | 213365 | 31473614 |
Drug eruption | 40.35 | 17.21 | 39 | 10326 | 18148 | 31668831 |
Drug-induced liver injury | 39.22 | 17.21 | 44 | 10321 | 24319 | 31662660 |
Delirium | 35.70 | 17.21 | 55 | 10310 | 41366 | 31645613 |
Altered state of consciousness | 35.58 | 17.21 | 39 | 10326 | 21012 | 31665967 |
Cancer pain | 35.21 | 17.21 | 17 | 10348 | 2516 | 31684463 |
Malaise | 34.40 | 17.21 | 127 | 10238 | 168384 | 31518595 |
Gastrointestinal perforation | 32.13 | 17.21 | 18 | 10347 | 3614 | 31683365 |
Upper respiratory tract inflammation | 31.84 | 17.21 | 14 | 10351 | 1672 | 31685307 |
Gastric ulcer | 31.74 | 17.21 | 31 | 10334 | 14603 | 31672376 |
Erythema multiforme | 31.64 | 17.21 | 24 | 10341 | 8047 | 31678932 |
Aspartate aminotransferase increased | 30.58 | 17.21 | 65 | 10300 | 62654 | 31624325 |
Gastric ulcer haemorrhage | 28.83 | 17.21 | 19 | 10346 | 5104 | 31681875 |
Enterocolitis | 27.13 | 17.21 | 21 | 10344 | 7253 | 31679726 |
C-reactive protein increased | 26.76 | 17.21 | 53 | 10312 | 48597 | 31638382 |
Hyperuricaemia | 26.72 | 17.21 | 21 | 10344 | 7417 | 31679562 |
Lymphangiosis carcinomatosa | 26.07 | 17.21 | 10 | 10355 | 844 | 31686135 |
Blood bilirubin increased | 25.29 | 17.21 | 43 | 10322 | 35093 | 31651886 |
Hypothyroidism | 24.84 | 17.21 | 30 | 10335 | 17917 | 31669062 |
Pharyngitis | 24.78 | 17.21 | 20 | 10345 | 7338 | 31679641 |
Pneumonia bacterial | 24.58 | 17.21 | 23 | 10342 | 10273 | 31676706 |
Cerebral infarction | 24.52 | 17.21 | 36 | 10329 | 25941 | 31661038 |
Death | 24.38 | 17.21 | 51 | 10314 | 360518 | 31326461 |
Duodenal ulcer | 23.67 | 17.21 | 22 | 10343 | 9742 | 31677237 |
Hypoalbuminaemia | 23.24 | 17.21 | 23 | 10342 | 11005 | 31675974 |
Prescribed underdose | 22.72 | 17.21 | 20 | 10345 | 8258 | 31678721 |
Product dose omission issue | 21.95 | 17.21 | 4 | 10361 | 105582 | 31581397 |
Hypotension | 21.68 | 17.21 | 21 | 10344 | 204597 | 31482382 |
Palmar-plantar erythrodysaesthesia syndrome | 21.62 | 17.21 | 26 | 10339 | 15457 | 31671522 |
Alanine aminotransferase increased | 21.21 | 17.21 | 63 | 10302 | 74593 | 31612386 |
Pneumonia aspiration | 21.06 | 17.21 | 42 | 10323 | 38684 | 31648295 |
Blood lactate dehydrogenase increased | 20.38 | 17.21 | 29 | 10336 | 20310 | 31666669 |
Adrenocorticotropic hormone deficiency | 20.36 | 17.21 | 8 | 10357 | 720 | 31686259 |
Peritonitis | 20.21 | 17.21 | 25 | 10340 | 15302 | 31671677 |
Anxiety | 19.92 | 17.21 | 3 | 10362 | 91030 | 31595949 |
Infective spondylitis | 19.84 | 17.21 | 6 | 10359 | 245 | 31686734 |
Rash | 19.83 | 17.21 | 123 | 10242 | 201363 | 31485616 |
Haemorrhage subcutaneous | 19.78 | 17.21 | 11 | 10354 | 2177 | 31684802 |
Eosinophil count increased | 19.75 | 17.21 | 18 | 10347 | 7773 | 31679206 |
Pneumonia | 19.62 | 17.21 | 181 | 10184 | 335131 | 31351848 |
Rhinitis allergic | 19.59 | 17.21 | 12 | 10353 | 2842 | 31684137 |
Duodenal perforation | 19.36 | 17.21 | 9 | 10356 | 1223 | 31685756 |
Adrenal insufficiency | 18.91 | 17.21 | 22 | 10343 | 12637 | 31674342 |
Paralysis recurrent laryngeal nerve | 18.44 | 17.21 | 4 | 10361 | 41 | 31686938 |
Colon cancer | 18.22 | 17.21 | 18 | 10347 | 8595 | 31678384 |
Hepatocellular carcinoma | 17.97 | 17.21 | 18 | 10347 | 8738 | 31678241 |
Constipation | 17.82 | 17.21 | 84 | 10281 | 123907 | 31563072 |
Hypocalcaemia | 17.29 | 17.21 | 28 | 10337 | 21950 | 31665029 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Interstitial lung disease | 666.55 | 15.94 | 413 | 21965 | 104272 | 70801794 |
Platelet count decreased | 491.88 | 15.94 | 424 | 21954 | 177798 | 70728268 |
Malignant neoplasm progression | 394.34 | 15.94 | 318 | 22060 | 121421 | 70784645 |
Hepatic function abnormal | 388.99 | 15.94 | 251 | 22127 | 67745 | 70838321 |
White blood cell count decreased | 242.32 | 15.94 | 283 | 22095 | 169858 | 70736208 |
Neutrophil count decreased | 228.26 | 15.94 | 198 | 22180 | 83358 | 70822708 |
Osteonecrosis of jaw | 169.48 | 15.94 | 124 | 22254 | 40878 | 70865188 |
Fatigue | 152.04 | 15.94 | 37 | 22341 | 824282 | 70081784 |
Disseminated intravascular coagulation | 144.28 | 15.94 | 104 | 22274 | 33494 | 70872572 |
Anaemia | 139.66 | 15.94 | 357 | 22021 | 403066 | 70503000 |
Decreased appetite | 138.43 | 15.94 | 300 | 22078 | 304480 | 70601586 |
Drug ineffective | 137.14 | 15.94 | 63 | 22315 | 939689 | 69966377 |
Drug eruption | 118.81 | 15.94 | 99 | 22279 | 39397 | 70866669 |
Liver disorder | 118.16 | 15.94 | 120 | 22258 | 61448 | 70844618 |
Pyrexia | 113.09 | 15.94 | 433 | 21945 | 606519 | 70299547 |
Gastrointestinal perforation | 95.47 | 15.94 | 43 | 22335 | 5638 | 70900428 |
Renal impairment | 91.03 | 15.94 | 163 | 22215 | 143774 | 70762292 |
Erythema multiforme | 86.88 | 15.94 | 58 | 22320 | 16506 | 70889560 |
Upper respiratory tract inflammation | 86.43 | 15.94 | 36 | 22342 | 3906 | 70902160 |
Drug-induced liver injury | 80.77 | 15.94 | 94 | 22284 | 56019 | 70850047 |
Spinal compression fracture | 80.47 | 15.94 | 54 | 22324 | 15499 | 70890567 |
Enterocolitis | 78.95 | 15.94 | 50 | 22328 | 13016 | 70893050 |
Cerebral infarction | 77.39 | 15.94 | 81 | 22297 | 42928 | 70863138 |
Confusional state | 76.70 | 15.94 | 3 | 22375 | 284395 | 70621671 |
Altered state of consciousness | 74.93 | 15.94 | 77 | 22301 | 39945 | 70866121 |
Toxicity to various agents | 72.51 | 15.94 | 16 | 22362 | 382156 | 70523910 |
Cancer pain | 66.69 | 15.94 | 32 | 22346 | 4842 | 70901224 |
Asthenia | 65.99 | 15.94 | 31 | 22347 | 457635 | 70448431 |
Pneumonia bacterial | 65.74 | 15.94 | 49 | 22329 | 16592 | 70889474 |
Stomatitis | 65.73 | 15.94 | 133 | 22245 | 128378 | 70777688 |
Haemorrhage subcutaneous | 62.90 | 15.94 | 30 | 22348 | 4479 | 70901587 |
Hypoalbuminaemia | 59.71 | 15.94 | 49 | 22329 | 19073 | 70886993 |
Joint swelling | 58.48 | 15.94 | 6 | 22372 | 253205 | 70652861 |
Pharyngitis | 57.04 | 15.94 | 49 | 22329 | 20302 | 70885764 |
Completed suicide | 56.22 | 15.94 | 4 | 22374 | 227131 | 70678935 |
Febrile neutropenia | 55.71 | 15.94 | 166 | 22212 | 204152 | 70701914 |
Aspartate aminotransferase increased | 55.19 | 15.94 | 123 | 22255 | 126855 | 70779211 |
Product dose omission issue | 53.34 | 15.94 | 4 | 22374 | 217464 | 70688602 |
Colon cancer | 51.81 | 15.94 | 40 | 22338 | 14266 | 70891800 |
Drug hypersensitivity | 51.79 | 15.94 | 10 | 22368 | 262449 | 70643617 |
Delirium | 51.67 | 15.94 | 88 | 22290 | 74526 | 70831540 |
Drug intolerance | 50.46 | 15.94 | 6 | 22372 | 225681 | 70680385 |
Hyperuricaemia | 49.48 | 15.94 | 35 | 22343 | 10931 | 70895135 |
Peritonitis | 48.36 | 15.94 | 50 | 22328 | 26109 | 70879957 |
Hypotension | 47.51 | 15.94 | 35 | 22343 | 404346 | 70501720 |
Cardiac failure | 47.34 | 15.94 | 125 | 22253 | 143416 | 70762650 |
Lymphangiosis carcinomatosa | 47.27 | 15.94 | 19 | 22359 | 1882 | 70904184 |
Radiation pneumonitis | 46.78 | 15.94 | 23 | 22355 | 3670 | 70902396 |
Peripheral swelling | 46.69 | 15.94 | 9 | 22369 | 236554 | 70669512 |
Blood bilirubin increased | 45.97 | 15.94 | 74 | 22304 | 59827 | 70846239 |
Cholangitis | 45.60 | 15.94 | 34 | 22344 | 11515 | 70894551 |
Enteritis infectious | 43.99 | 15.94 | 21 | 22357 | 3141 | 70902925 |
Gastric ulcer | 42.01 | 15.94 | 51 | 22327 | 31739 | 70874327 |
Dyspnoea | 40.82 | 15.94 | 117 | 22261 | 769943 | 70136123 |
Ileus | 40.67 | 15.94 | 44 | 22334 | 24193 | 70881873 |
Alanine aminotransferase increased | 40.34 | 15.94 | 120 | 22258 | 147360 | 70758706 |
Pneumonia | 39.05 | 15.94 | 321 | 22057 | 595911 | 70310155 |
Femoral neck fracture | 38.73 | 15.94 | 28 | 22350 | 9045 | 70897021 |
Hypopituitarism | 38.64 | 15.94 | 19 | 22359 | 3031 | 70903035 |
Malaise | 38.00 | 15.94 | 250 | 22128 | 432682 | 70473384 |
Swelling | 37.57 | 15.94 | 7 | 22371 | 188532 | 70717534 |
Fulminant type 1 diabetes mellitus | 36.40 | 15.94 | 14 | 22364 | 1233 | 70904833 |
Pain | 35.95 | 15.94 | 92 | 22286 | 628724 | 70277342 |
Iron deficiency anaemia | 35.46 | 15.94 | 40 | 22338 | 23032 | 70883034 |
Drug abuse | 35.28 | 15.94 | 3 | 22375 | 147253 | 70758813 |
Herpes zoster | 35.27 | 15.94 | 81 | 22297 | 85154 | 70820912 |
Pleural effusion | 34.35 | 15.94 | 106 | 22272 | 132758 | 70773308 |
Therapeutic product effect decreased | 34.03 | 15.94 | 3 | 22375 | 143015 | 70763051 |
Hypersensitivity | 33.95 | 15.94 | 15 | 22363 | 229797 | 70676269 |
Arthropathy | 33.50 | 15.94 | 4 | 22374 | 150053 | 70756013 |
Eczema | 33.43 | 15.94 | 47 | 22331 | 33734 | 70872332 |
Prescribed underdose | 32.74 | 15.94 | 37 | 22341 | 21348 | 70884718 |
Stevens-Johnson syndrome | 32.66 | 15.94 | 48 | 22330 | 35859 | 70870207 |
Tumour haemorrhage | 32.32 | 15.94 | 18 | 22360 | 3704 | 70902362 |
C-reactive protein increased | 32.20 | 15.94 | 92 | 22286 | 110425 | 70795641 |
Rhinitis allergic | 31.52 | 15.94 | 25 | 22353 | 9270 | 70896796 |
Adrenocorticotropic hormone deficiency | 31.43 | 15.94 | 12 | 22366 | 1036 | 70905030 |
Constipation | 31.41 | 15.94 | 160 | 22218 | 252278 | 70653788 |
Asteatosis | 31.28 | 15.94 | 7 | 22371 | 87 | 70905979 |
Gastric ulcer haemorrhage | 31.25 | 15.94 | 24 | 22354 | 8494 | 70897572 |
Weight increased | 31.08 | 15.94 | 19 | 22359 | 242312 | 70663754 |
Pain in extremity | 30.66 | 15.94 | 35 | 22343 | 328047 | 70578019 |
Renal disorder | 30.60 | 15.94 | 48 | 22330 | 37961 | 70868105 |
Haemoglobin decreased | 30.57 | 15.94 | 137 | 22241 | 205022 | 70701044 |
Gastroenteritis | 30.25 | 15.94 | 43 | 22335 | 31170 | 70874896 |
Pneumonia aspiration | 30.09 | 15.94 | 63 | 22315 | 62226 | 70843840 |
Pneumocystis jirovecii pneumonia | 29.98 | 15.94 | 42 | 22336 | 30040 | 70876026 |
Malignant pleural effusion | 29.51 | 15.94 | 16 | 22362 | 3123 | 70902943 |
Cerebrovascular accident | 29.29 | 15.94 | 5 | 22373 | 143465 | 70762601 |
Pulmonary alveolar haemorrhage | 29.12 | 15.94 | 25 | 22353 | 10344 | 70895722 |
Anxiety | 28.64 | 15.94 | 17 | 22361 | 220313 | 70685753 |
Hypocalcaemia | 28.56 | 15.94 | 51 | 22327 | 44808 | 70861258 |
Rheumatoid arthritis | 28.51 | 15.94 | 30 | 22348 | 291775 | 70614291 |
Paronychia | 28.32 | 15.94 | 21 | 22357 | 7053 | 70899013 |
Liver abscess | 27.91 | 15.94 | 19 | 22359 | 5580 | 70900486 |
Duodenal ulcer | 27.87 | 15.94 | 29 | 22349 | 15251 | 70890815 |
Gamma-glutamyltransferase increased | 27.74 | 15.94 | 54 | 22324 | 50631 | 70855435 |
Injection site dermatitis | 27.47 | 15.94 | 5 | 22373 | 19 | 70906047 |
Haemolytic anaemia | 27.33 | 15.94 | 30 | 22348 | 16764 | 70889302 |
Duodenal perforation | 26.72 | 15.94 | 13 | 22365 | 2027 | 70904039 |
Blood lactate dehydrogenase increased | 26.41 | 15.94 | 43 | 22335 | 35084 | 70870982 |
Weight decreased | 26.01 | 15.94 | 36 | 22342 | 310452 | 70595614 |
Pneumothorax | 25.63 | 15.94 | 36 | 22342 | 25810 | 70880256 |
Small intestine ulcer | 24.65 | 15.94 | 9 | 22369 | 686 | 70905380 |
Lymphocyte count decreased | 24.58 | 15.94 | 47 | 22331 | 43492 | 70862574 |
Syncope | 24.17 | 15.94 | 11 | 22367 | 165698 | 70740368 |
Infective spondylitis | 23.81 | 15.94 | 8 | 22370 | 477 | 70905589 |
Hepatocellular carcinoma | 23.50 | 15.94 | 22 | 22356 | 10186 | 70895880 |
Adrenal insufficiency | 23.38 | 15.94 | 34 | 22344 | 25161 | 70880905 |
Skin erosion | 23.34 | 15.94 | 15 | 22363 | 4001 | 70902065 |
Heart rate increased | 23.27 | 15.94 | 3 | 22375 | 106145 | 70799921 |
Hypothyroidism | 22.94 | 15.94 | 47 | 22331 | 45708 | 70860358 |
Palmar-plantar erythrodysaesthesia syndrome | 22.70 | 15.94 | 37 | 22341 | 30210 | 70875856 |
Immune-mediated enterocolitis | 22.55 | 15.94 | 14 | 22364 | 3517 | 70902549 |
Eczema asteatotic | 22.47 | 15.94 | 8 | 22370 | 567 | 70905499 |
Chronic gastritis | 22.26 | 15.94 | 14 | 22364 | 3599 | 70902467 |
Enterocolitis viral | 21.93 | 15.94 | 7 | 22371 | 355 | 70905711 |
Cholangitis acute | 21.64 | 15.94 | 10 | 22368 | 1390 | 70904676 |
Aortitis | 21.57 | 15.94 | 10 | 22368 | 1401 | 70904665 |
Dyslalia | 21.35 | 15.94 | 9 | 22369 | 1005 | 70905061 |
Death | 21.16 | 15.94 | 86 | 22292 | 509975 | 70396091 |
Atypical femur fracture | 20.79 | 15.94 | 15 | 22363 | 4828 | 70901238 |
Paraesthesia | 20.70 | 15.94 | 10 | 22368 | 145527 | 70760539 |
Shock haemorrhagic | 20.66 | 15.94 | 27 | 22351 | 18079 | 70887987 |
Melaena | 20.55 | 15.94 | 51 | 22327 | 56304 | 70849762 |
Blood urea increased | 20.52 | 15.94 | 45 | 22333 | 45864 | 70860202 |
Ascites | 20.42 | 15.94 | 57 | 22321 | 67490 | 70838576 |
Concomitant disease aggravated | 20.34 | 15.94 | 22 | 22356 | 12092 | 70893974 |
Diverticulum intestinal haemorrhagic | 20.28 | 15.94 | 13 | 22365 | 3454 | 70902612 |
Chest pain | 20.18 | 15.94 | 30 | 22348 | 251230 | 70654836 |
KL-6 increased | 20.12 | 15.94 | 5 | 22373 | 100 | 70905966 |
Periodontitis | 19.96 | 15.94 | 14 | 22364 | 4314 | 70901752 |
Breast cancer | 19.91 | 15.94 | 37 | 22341 | 33512 | 70872554 |
Lymphoproliferative disorder | 19.51 | 15.94 | 15 | 22363 | 5314 | 70900752 |
Tumour necrosis | 19.43 | 15.94 | 10 | 22368 | 1757 | 70904309 |
Rash | 19.41 | 15.94 | 246 | 22132 | 510316 | 70395750 |
Small intestinal perforation | 19.40 | 15.94 | 12 | 22366 | 2997 | 70903069 |
Sinusitis | 19.37 | 15.94 | 15 | 22363 | 169180 | 70736886 |
Non-small cell lung cancer | 19.26 | 15.94 | 16 | 22362 | 6331 | 70899735 |
Sudden hearing loss | 19.04 | 15.94 | 10 | 22368 | 1831 | 70904235 |
Wound | 18.96 | 15.94 | 4 | 22374 | 98728 | 70807338 |
Pyelonephritis | 18.92 | 15.94 | 26 | 22352 | 18263 | 70887803 |
Large intestine perforation | 18.80 | 15.94 | 22 | 22356 | 13173 | 70892893 |
Oculomucocutaneous syndrome | 18.48 | 15.94 | 6 | 22372 | 321 | 70905745 |
Duodenal ulcer haemorrhage | 18.47 | 15.94 | 16 | 22362 | 6702 | 70899364 |
Blood pressure decreased | 18.31 | 15.94 | 67 | 22311 | 91448 | 70814618 |
Dermatitis acneiform | 18.18 | 15.94 | 18 | 22360 | 8927 | 70897139 |
Wheezing | 17.71 | 15.94 | 4 | 22374 | 94166 | 70811900 |
Alopecia | 17.65 | 15.94 | 22 | 22356 | 198468 | 70707598 |
Subarachnoid haemorrhage | 17.63 | 15.94 | 26 | 22352 | 19478 | 70886588 |
Malignant ascites | 17.44 | 15.94 | 8 | 22370 | 1093 | 70904973 |
Lupus nephritis | 17.43 | 15.94 | 11 | 22367 | 2843 | 70903223 |
Product use in unapproved indication | 17.42 | 15.94 | 24 | 22354 | 207454 | 70698612 |
Blood alkaline phosphatase increased | 17.31 | 15.94 | 49 | 22329 | 58472 | 70847594 |
General physical health deterioration | 17.24 | 15.94 | 30 | 22348 | 236001 | 70670065 |
Blood creatine phosphokinase increased | 16.87 | 15.94 | 50 | 22328 | 61213 | 70844853 |
Pleurisy | 16.81 | 15.94 | 18 | 22360 | 9781 | 70896285 |
Off label use | 16.73 | 15.94 | 152 | 22226 | 742908 | 70163158 |
Colorectal cancer recurrent | 16.05 | 15.94 | 4 | 22374 | 81 | 70905985 |
None
Source | Code | Description |
---|---|---|
ATC | M02AA31 | MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use |
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
CHEBI has role | CHEBI:35493 | anti-pyretic |
CHEBI has role | CHEBI:35544 | cyclooxygenase inhibitors |
CHEBI has role | CHEBI:50266 | Prodrugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.37 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 5 | CHEMBL | KEGG DRUG | |||
Prostaglandin G/H synthase 1 | Enzyme | INHIBITOR | IC50 | 5.19 | CHEMBL | KEGG DRUG |
ID | Source |
---|---|
D08149 | KEGG_DRUG |
C0065199 | UMLSCUI |
CHEBI:31786 | CHEBI |
CHEMBL19299 | ChEMBL_ID |
DB09212 | DRUGBANK_ID |
C040656 | MESH_SUPPLEMENTAL_RECORD_UI |
3965 | PUBCHEM_CID |
5410 | INN_ID |
80382-23-6 | SECONDARY_CAS_RN |
3583H0GZAP | UNII |
28908 | RXNORM |
008162 | NDDF |
18991000122102 | SNOMEDCT_US |
CHEMBL66552 | ChEMBL_ID |
None