Stem definition | Drug id | CAS RN |
---|---|---|
HIV protease inhibitors | 1601 | 192725-17-0 |
Dose | Unit | Route |
---|---|---|
0.80 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 2.20 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 24.22 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 15, 2000 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Exposure during pregnancy | 1679.26 | 50.79 | 409 | 1490 | 24810 | 2331376 |
Abortion spontaneous | 918.67 | 50.79 | 225 | 1674 | 13220 | 2342966 |
Foetal exposure during pregnancy | 723.03 | 50.79 | 156 | 1743 | 5096 | 2351090 |
Stillbirth | 540.12 | 50.79 | 99 | 1800 | 1342 | 2354844 |
Abortion induced | 510.94 | 50.79 | 109 | 1790 | 3327 | 2352859 |
Maternal exposure during pregnancy | 417.28 | 50.79 | 124 | 1775 | 14739 | 2341447 |
Premature baby | 349.84 | 50.79 | 79 | 1820 | 3125 | 2353061 |
Foetal death | 349.09 | 50.79 | 72 | 1827 | 1840 | 2354346 |
Premature labour | 219.15 | 50.79 | 50 | 1849 | 2056 | 2354130 |
Live birth | 208.63 | 50.79 | 44 | 1855 | 1247 | 2354939 |
Pregnancy | 203.50 | 50.79 | 62 | 1837 | 7887 | 2348299 |
Viral mutation identified | 193.26 | 50.79 | 32 | 1867 | 223 | 2355963 |
Anaemia | 192.83 | 50.79 | 88 | 1811 | 34704 | 2321482 |
Premature rupture of membranes | 187.98 | 50.79 | 38 | 1861 | 868 | 2355318 |
Caesarean section | 172.19 | 50.79 | 47 | 1852 | 4034 | 2352152 |
Drug interaction | 146.47 | 50.79 | 69 | 1830 | 29094 | 2327092 |
Drug resistance | 142.88 | 50.79 | 37 | 1862 | 2587 | 2353599 |
Immune reconstitution inflammatory syndrome | 131.80 | 50.79 | 30 | 1869 | 1214 | 2354972 |
Foetal growth restriction | 123.51 | 50.79 | 28 | 1871 | 1112 | 2355074 |
Vomiting | 116.40 | 50.79 | 81 | 1818 | 71521 | 2284665 |
Virologic failure | 109.04 | 50.79 | 20 | 1879 | 266 | 2355920 |
Skull malformation | 105.68 | 50.79 | 17 | 1882 | 96 | 2356090 |
Pre-eclampsia | 100.55 | 50.79 | 25 | 1874 | 1479 | 2354707 |
Hepatitis | 87.30 | 50.79 | 31 | 1868 | 6306 | 2349880 |
Premature delivery | 86.14 | 50.79 | 26 | 1873 | 3174 | 2353012 |
Diarrhoea | 83.78 | 50.79 | 71 | 1828 | 83493 | 2272693 |
Cushing's syndrome | 83.39 | 50.79 | 19 | 1880 | 770 | 2355416 |
Spina bifida | 81.41 | 50.79 | 14 | 1885 | 125 | 2356061 |
Patent ductus arteriosus | 80.85 | 50.79 | 18 | 1881 | 656 | 2355530 |
Pyrexia | 80.62 | 50.79 | 58 | 1841 | 53650 | 2302536 |
Viral load increased | 78.49 | 50.79 | 15 | 1884 | 252 | 2355934 |
Cerebral ventricle dilatation | 76.25 | 50.79 | 14 | 1885 | 187 | 2355999 |
HIV infection | 74.54 | 50.79 | 13 | 1886 | 127 | 2356059 |
Normal newborn | 73.96 | 50.79 | 19 | 1880 | 1281 | 2354905 |
Portal hypertension | 73.19 | 50.79 | 16 | 1883 | 535 | 2355651 |
Lipodystrophy acquired | 70.70 | 50.79 | 14 | 1885 | 285 | 2355901 |
Abdominal pain | 70.29 | 50.79 | 45 | 1854 | 34329 | 2321857 |
Trisomy 21 | 67.93 | 50.79 | 12 | 1887 | 127 | 2356059 |
Nausea | 67.72 | 50.79 | 72 | 1827 | 112117 | 2244069 |
Pulmonary tuberculosis | 65.65 | 50.79 | 16 | 1883 | 869 | 2355317 |
Oligohydramnios | 64.35 | 50.79 | 16 | 1883 | 944 | 2355242 |
Placental disorder | 63.29 | 50.79 | 13 | 1886 | 320 | 2355866 |
Ventricular septal defect | 61.86 | 50.79 | 15 | 1884 | 797 | 2355389 |
Placenta praevia | 61.23 | 50.79 | 12 | 1887 | 231 | 2355955 |
Placental insufficiency | 60.52 | 50.79 | 12 | 1887 | 246 | 2355940 |
Acute kidney injury | 60.40 | 50.79 | 38 | 1861 | 28084 | 2328102 |
Coarctation of the aorta | 59.90 | 50.79 | 11 | 1888 | 147 | 2356039 |
Gestational diabetes | 58.51 | 50.79 | 16 | 1883 | 1371 | 2354815 |
Polydactyly | 56.76 | 50.79 | 10 | 1889 | 104 | 2356082 |
Dysmorphism | 55.01 | 50.79 | 12 | 1887 | 397 | 2355789 |
Mitochondrial cytopathy | 54.02 | 50.79 | 9 | 1890 | 65 | 2356121 |
Treatment noncompliance | 53.89 | 50.79 | 21 | 1878 | 5513 | 2350673 |
Congenital anomaly | 52.97 | 50.79 | 12 | 1887 | 473 | 2355713 |
Genotype drug resistance test positive | 52.36 | 50.79 | 9 | 1890 | 80 | 2356106 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Foetal exposure during pregnancy | 710.10 | 36.90 | 186 | 2373 | 6173 | 1738049 |
Lipodystrophy acquired | 614.95 | 36.90 | 102 | 2457 | 271 | 1743951 |
Mitochondrial toxicity | 452.72 | 36.90 | 72 | 2487 | 130 | 1744092 |
Exposure during pregnancy | 389.28 | 36.90 | 98 | 2461 | 2719 | 1741503 |
Eyelid ptosis | 353.66 | 36.90 | 71 | 2488 | 666 | 1743556 |
Diarrhoea | 345.50 | 36.90 | 194 | 2365 | 53658 | 1690564 |
Premature baby | 341.03 | 36.90 | 89 | 2470 | 2853 | 1741369 |
Immune reconstitution inflammatory syndrome | 338.21 | 36.90 | 78 | 2481 | 1471 | 1742751 |
Progressive external ophthalmoplegia | 284.22 | 36.90 | 41 | 2518 | 19 | 1744203 |
Drug interaction | 282.38 | 36.90 | 137 | 2422 | 27821 | 1716401 |
Diplopia | 246.56 | 36.90 | 67 | 2492 | 2503 | 1741719 |
Hyperlipidaemia | 190.06 | 36.90 | 53 | 2506 | 2176 | 1742046 |
Pyrexia | 180.26 | 36.90 | 122 | 2437 | 46278 | 1697944 |
Vomiting | 176.14 | 36.90 | 112 | 2447 | 38203 | 1706019 |
Nausea | 171.70 | 36.90 | 123 | 2436 | 51073 | 1693149 |
Weight decreased | 152.63 | 36.90 | 85 | 2474 | 22668 | 1721554 |
Anaemia | 152.56 | 36.90 | 93 | 2466 | 29364 | 1714858 |
Kaposi's sarcoma | 148.89 | 36.90 | 36 | 2523 | 831 | 1743391 |
Hyperlactacidaemia | 142.00 | 36.90 | 30 | 2529 | 366 | 1743856 |
Depression | 138.94 | 36.90 | 72 | 2487 | 16597 | 1727625 |
Hypertriglyceridaemia | 137.01 | 36.90 | 36 | 2523 | 1173 | 1743049 |
Trisomy 21 | 136.63 | 36.90 | 24 | 2535 | 97 | 1744125 |
Acute kidney injury | 133.19 | 36.90 | 91 | 2468 | 34853 | 1709369 |
Abdominal pain | 129.77 | 36.90 | 75 | 2484 | 21415 | 1722807 |
Pancytopenia | 124.05 | 36.90 | 59 | 2500 | 11298 | 1732924 |
Fanconi syndrome | 123.21 | 36.90 | 26 | 2533 | 315 | 1743907 |
Blood triglycerides increased | 122.02 | 36.90 | 39 | 2520 | 2561 | 1741661 |
Osteonecrosis | 117.13 | 36.90 | 42 | 2517 | 3920 | 1740302 |
Liver disorder | 113.11 | 36.90 | 45 | 2514 | 5591 | 1738631 |
Congenital anomaly | 111.83 | 36.90 | 25 | 2534 | 403 | 1743819 |
Drug resistance | 109.82 | 36.90 | 38 | 2521 | 3192 | 1741030 |
Cryptorchism | 104.74 | 36.90 | 23 | 2536 | 340 | 1743882 |
Cerebral toxoplasmosis | 102.72 | 36.90 | 20 | 2539 | 156 | 1744066 |
Renal failure | 100.29 | 36.90 | 62 | 2497 | 19955 | 1724267 |
Renal impairment | 99.06 | 36.90 | 52 | 2507 | 12262 | 1731960 |
Renal tubular disorder | 98.84 | 36.90 | 26 | 2533 | 849 | 1743373 |
General physical health deterioration | 98.76 | 36.90 | 53 | 2506 | 13065 | 1731157 |
Cushing's syndrome | 98.16 | 36.90 | 24 | 2535 | 580 | 1743642 |
Polydactyly | 97.64 | 36.90 | 20 | 2539 | 207 | 1744015 |
Hepatic cirrhosis | 97.14 | 36.90 | 33 | 2526 | 2620 | 1741602 |
Asthenia | 94.89 | 36.90 | 74 | 2485 | 34596 | 1709626 |
Abdominal distension | 94.03 | 36.90 | 41 | 2518 | 6403 | 1737819 |
Lactic acidosis | 92.71 | 36.90 | 38 | 2521 | 5091 | 1739131 |
Pneumocystis jirovecii pneumonia | 91.69 | 36.90 | 31 | 2528 | 2425 | 1741797 |
Hypokalaemia | 91.20 | 36.90 | 40 | 2519 | 6334 | 1737888 |
Dysphagia | 90.57 | 36.90 | 46 | 2513 | 10122 | 1734100 |
Cardiac murmur | 90.25 | 36.90 | 26 | 2533 | 1196 | 1743026 |
Viral load increased | 88.80 | 36.90 | 22 | 2537 | 562 | 1743660 |
Portal hypertension | 85.29 | 36.90 | 22 | 2537 | 664 | 1743558 |
Osteoporosis | 84.06 | 36.90 | 26 | 2533 | 1529 | 1742693 |
Progressive multifocal leukoencephalopathy | 82.71 | 36.90 | 26 | 2533 | 1613 | 1742609 |
Ventricular septal defect | 82.54 | 36.90 | 22 | 2537 | 756 | 1743466 |
Abdominal hernia | 81.98 | 36.90 | 19 | 2540 | 362 | 1743860 |
Headache | 78.39 | 36.90 | 66 | 2493 | 34310 | 1709912 |
Hepatitis | 77.09 | 36.90 | 33 | 2526 | 4922 | 1739300 |
Maternal drugs affecting foetus | 73.64 | 36.90 | 22 | 2537 | 1149 | 1743073 |
HIV-associated neurocognitive disorder | 72.40 | 36.90 | 13 | 2546 | 61 | 1744161 |
Virologic failure | 70.39 | 36.90 | 17 | 2542 | 389 | 1743833 |
Atypical mycobacterial infection | 66.98 | 36.90 | 14 | 2545 | 161 | 1744061 |
Gamma-glutamyltransferase increased | 66.50 | 36.90 | 30 | 2529 | 5068 | 1739154 |
Blood alkaline phosphatase increased | 65.95 | 36.90 | 30 | 2529 | 5165 | 1739057 |
Cytomegalovirus chorioretinitis | 65.80 | 36.90 | 16 | 2543 | 377 | 1743845 |
Blood lactic acid increased | 65.80 | 36.90 | 19 | 2540 | 880 | 1743342 |
Aspartate aminotransferase increased | 63.28 | 36.90 | 37 | 2522 | 10719 | 1733503 |
Oral candidiasis | 62.86 | 36.90 | 20 | 2539 | 1289 | 1742933 |
Gastritis | 62.86 | 36.90 | 25 | 2534 | 3092 | 1741130 |
Lymphadenopathy | 62.66 | 36.90 | 27 | 2532 | 4087 | 1740135 |
Pneumonia | 61.77 | 36.90 | 66 | 2493 | 46116 | 1698106 |
Thrombocytopenia | 61.56 | 36.90 | 47 | 2512 | 21202 | 1723020 |
Jaundice | 61.54 | 36.90 | 30 | 2529 | 6032 | 1738190 |
Lipoatrophy | 60.69 | 36.90 | 12 | 2547 | 102 | 1744120 |
Dehydration | 59.99 | 36.90 | 43 | 2516 | 17615 | 1726607 |
Oesophageal candidiasis | 59.95 | 36.90 | 16 | 2543 | 552 | 1743670 |
Decreased appetite | 58.83 | 36.90 | 48 | 2511 | 23823 | 1720399 |
Alanine aminotransferase increased | 58.76 | 36.90 | 37 | 2522 | 12241 | 1731981 |
Diabetes mellitus | 57.82 | 36.90 | 30 | 2529 | 6878 | 1737344 |
Mycobacterium avium complex infection | 57.81 | 36.90 | 14 | 2545 | 324 | 1743898 |
Ascites | 57.76 | 36.90 | 28 | 2531 | 5558 | 1738664 |
Ophthalmoplegia | 57.26 | 36.90 | 13 | 2546 | 225 | 1743997 |
Hepatic function abnormal | 57.15 | 36.90 | 30 | 2529 | 7044 | 1737178 |
Viral mutation identified | 56.25 | 36.90 | 14 | 2545 | 364 | 1743858 |
HIV infection | 55.91 | 36.90 | 13 | 2546 | 251 | 1743971 |
Gastrointestinal disorder | 55.82 | 36.90 | 26 | 2533 | 4722 | 1739500 |
Acquired immunodeficiency syndrome | 55.38 | 36.90 | 11 | 2548 | 96 | 1744126 |
Blood bilirubin increased | 54.95 | 36.90 | 28 | 2531 | 6182 | 1738040 |
Hypophosphataemia | 54.72 | 36.90 | 18 | 2541 | 1290 | 1742932 |
Nephropathy toxic | 53.54 | 36.90 | 19 | 2540 | 1713 | 1742509 |
Blood cholesterol increased | 53.21 | 36.90 | 22 | 2537 | 3004 | 1741218 |
Hyponatraemia | 53.03 | 36.90 | 31 | 2528 | 8969 | 1735253 |
Foetal growth restriction | 52.48 | 36.90 | 15 | 2544 | 669 | 1743553 |
Malaise | 51.85 | 36.90 | 49 | 2510 | 29516 | 1714706 |
Oesophageal atresia | 51.80 | 36.90 | 10 | 2549 | 74 | 1744148 |
Myocardial infarction | 51.44 | 36.90 | 47 | 2512 | 27127 | 1717095 |
Dysmorphism | 50.64 | 36.90 | 13 | 2546 | 384 | 1743838 |
Nervous system disorder | 50.58 | 36.90 | 20 | 2539 | 2434 | 1741788 |
C-reactive protein increased | 50.52 | 36.90 | 26 | 2533 | 5859 | 1738363 |
Low set ears | 50.47 | 36.90 | 10 | 2549 | 86 | 1744136 |
Small for dates baby | 49.82 | 36.90 | 14 | 2545 | 587 | 1743635 |
Neuropathy peripheral | 49.63 | 36.90 | 30 | 2529 | 9223 | 1734999 |
Kidney malformation | 49.00 | 36.90 | 9 | 2550 | 49 | 1744173 |
Fanconi syndrome acquired | 48.47 | 36.90 | 13 | 2546 | 457 | 1743765 |
Mitochondrial cytopathy | 48.40 | 36.90 | 9 | 2550 | 53 | 1744169 |
Hypercholesterolaemia | 47.98 | 36.90 | 16 | 2543 | 1196 | 1743026 |
Coronary artery disease | 47.91 | 36.90 | 30 | 2529 | 9816 | 1734406 |
Gastroschisis | 46.88 | 36.90 | 8 | 2551 | 26 | 1744196 |
Leukopenia | 46.78 | 36.90 | 28 | 2531 | 8452 | 1735770 |
Cachexia | 46.63 | 36.90 | 15 | 2544 | 1001 | 1743221 |
Atrial septal defect | 46.20 | 36.90 | 16 | 2543 | 1342 | 1742880 |
Volvulus | 45.48 | 36.90 | 11 | 2548 | 253 | 1743969 |
Dyslipidaemia | 45.44 | 36.90 | 14 | 2545 | 811 | 1743411 |
Encephalitis | 44.96 | 36.90 | 15 | 2544 | 1123 | 1743099 |
Hepatitis C | 44.70 | 36.90 | 19 | 2540 | 2777 | 1741445 |
Proteinuria | 44.39 | 36.90 | 19 | 2540 | 2825 | 1741397 |
Tachypnoea | 44.37 | 36.90 | 18 | 2541 | 2340 | 1741882 |
Rash | 44.23 | 36.90 | 51 | 2508 | 38642 | 1705580 |
Sepsis | 43.51 | 36.90 | 37 | 2522 | 19401 | 1724821 |
Syphilis | 43.25 | 36.90 | 9 | 2550 | 101 | 1744121 |
HIV associated nephropathy | 43.13 | 36.90 | 7 | 2552 | 15 | 1744207 |
Hepatic steatosis | 42.78 | 36.90 | 18 | 2541 | 2566 | 1741656 |
Femoral neck fracture | 42.77 | 36.90 | 12 | 2547 | 500 | 1743722 |
Exomphalos | 42.75 | 36.90 | 8 | 2551 | 49 | 1744173 |
Hepatic failure | 41.96 | 36.90 | 23 | 2536 | 5880 | 1738342 |
Bone marrow failure | 41.83 | 36.90 | 22 | 2537 | 5178 | 1739044 |
Herpes zoster | 41.55 | 36.90 | 21 | 2538 | 4552 | 1739670 |
Hyperbilirubinaemia | 41.46 | 36.90 | 17 | 2542 | 2270 | 1741952 |
Anogenital warts | 41.03 | 36.90 | 9 | 2550 | 132 | 1744090 |
Congenital hearing disorder | 40.96 | 36.90 | 7 | 2552 | 23 | 1744199 |
Stillbirth | 40.78 | 36.90 | 8 | 2551 | 65 | 1744157 |
Caesarean section | 40.59 | 36.90 | 12 | 2547 | 603 | 1743619 |
Varices oesophageal | 40.31 | 36.90 | 12 | 2547 | 618 | 1743604 |
Hepatosplenomegaly | 40.18 | 36.90 | 12 | 2547 | 625 | 1743597 |
Liver function test abnormal | 39.84 | 36.90 | 22 | 2537 | 5704 | 1738518 |
Dyspnoea | 39.55 | 36.90 | 56 | 2503 | 52003 | 1692219 |
Neutropenia | 39.31 | 36.90 | 34 | 2525 | 18226 | 1725996 |
Adrenal insufficiency | 38.52 | 36.90 | 14 | 2545 | 1351 | 1742871 |
Opportunistic infection | 38.00 | 36.90 | 10 | 2549 | 326 | 1743896 |
Seizure | 37.94 | 36.90 | 35 | 2524 | 20406 | 1723816 |
Cough | 37.84 | 36.90 | 34 | 2525 | 19163 | 1725059 |
Source | Code | Description |
---|---|---|
ATC | J05AR10 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
FDA EPC | N0000175889 | Protease Inhibitor |
FDA MoA | N0000185503 | P-Glycoprotein Inhibitors |
FDA MoA | N0000190114 | Cytochrome P450 3A Inhibitors |
FDA MoA | N0000190107 | Organic Anion Transporting Polypeptide 1B1 Inhibitors |
MeSH PA | D019380 | Anti-HIV Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D044966 | Anti-Retroviral Agents |
MeSH PA | D000998 | Antiviral Agents |
MeSH PA | D065692 | Cytochrome P-450 CYP3A Inhibitors |
MeSH PA | D065607 | Cytochrome P-450 Enzyme Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D017320 | HIV Protease Inhibitors |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D011480 | Protease Inhibitors |
CHEBI has role | CHEBI:36044 | antiviral drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Human immunodeficiency virus infection | indication | 86406008 | DOID:526 |
Coronavirus infection | off-label use | 186747009 | |
Prevention of HIV Infection after Exposure | off-label use | ||
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Complete atrioventricular block | contraindication | 27885002 | |
Hereditary factor VIII deficiency disease | contraindication | 28293008 | DOID:12134 |
Torsades de pointes | contraindication | 31722008 | |
Hereditary factor IX deficiency disease | contraindication | 41788008 | DOID:12259 |
Hypokalemia | contraindication | 43339004 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Chronic type B viral hepatitis | contraindication | 61977001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Cardiomyopathy | contraindication | 85898001 | DOID:0050700 |
Prolonged QT interval | contraindication | 111975006 | |
Chronic hepatitis C | contraindication | 128302006 | |
Structural disorder of heart | contraindication | 128599005 | |
Liver function tests abnormal | contraindication | 166603001 | |
Hypomagnesemia | contraindication | 190855004 | |
Second degree atrioventricular block | contraindication | 195042002 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Mixed hyperlipidemia | contraindication | 267434003 | |
Hypertriglyceridemia | contraindication | 302870006 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Congenital long QT syndrome | contraindication | 442917000 | |
First Degree Atrioventricular Heart Block | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.03 | acidic |
pKa2 | 12.72 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Multidrug resistance protein 1 | Transporter | IC50 | 4.99 | CHEMBL | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.07 | CHEMBL | |||||
Pol polyprotein | Enzyme | INHIBITOR | Ki | 10.40 | CHEMBL | CHEMBL | |||
Gag-Pol polyprotein | Polyprotein | WOMBAT-PK | |||||||
CAAX prenyl protease 1 homolog | Enzyme | IC50 | 4.74 | CHEMBL | |||||
Protease | Enzyme | IC50 | 7.60 | CHEMBL |
ID | Source |
---|---|
4021228 | VUID |
N0000179581 | NUI |
C0674432 | UMLSCUI |
D01425 | KEGG_DRUG |
2494G1JF75 | UNII |
7798 | INN_ID |
129475001 | SNOMEDCT_US |
d04716 | MMSL |
15774 | MMSL |
195088 | RXNORM |
4021228 | VANDF |
387067003 | SNOMEDCT_US |
008874 | NDDF |
CHEMBL729 | ChEMBL_ID |
AB1 | PDB_CHEM_ID |
DB01601 | DRUGBANK_ID |
CHEBI:31781 | CHEBI |
D061466 | MESH_DESCRIPTOR_UI |
92727 | PUBCHEM_CID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0074-0522 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 18 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0074-1575 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 18 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0074-2605 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 18 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0074-3956 | SOLUTION | 80 mg | ORAL | NDA | 18 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0074-6799 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 18 sections |
Lopinavir-Ritonavir | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0527-1947 | SOLUTION | 80 mg | ORAL | ANDA | 19 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 11819-342 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 18 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-362 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 18 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 53808-0276 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 18 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-5566 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 18 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 55289-947 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 18 sections |
Lopinavir and Ritonavir | HUMAN PRESCRIPTION DRUG LABEL | 2 | 65015-299 | GRANULE | 40 mg | ORAL | Export only | 1 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 66336-624 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 18 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 68258-1972 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 18 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 70518-0091 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 18 sections |