ipratropium ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
atropine derivatives 1475 60205-81-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ipratropium
  • ipratropium bromide
  • ipratropium bromide hydrate
  • ipratropium bromide monohydrate
A muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic.
  • Molecular weight: 332.46
  • Formula: C20H30NO3
  • CLOGP: -2.19
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -5.48
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.24 mg N
0.12 mg Inhal.aerosol
0.12 mg Inhal.powder
0.30 mg Inhal.solution

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.01 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 3 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 5.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 31.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.95 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.64 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1986 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 1287.45 10.87 1005 56755 126556 63304706
Wheezing 829.22 10.87 690 57070 94905 63336357
Obstructive airways disorder 580.70 10.87 311 57449 20388 63410874
Chronic obstructive pulmonary disease 494.91 10.87 429 57331 62257 63369005
Dyspnoea 480.94 10.87 1502 56258 659811 62771451
Sleep disorder due to a general medical condition 341.40 10.87 183 57577 12005 63419257
Pneumonia 254.40 10.87 951 56809 455816 62975446
Cough 254.23 10.87 710 57050 292033 63139229
Productive cough 245.35 10.87 295 57465 62913 63368349
Chest discomfort 222.52 10.87 376 57384 109593 63321669
Full blood count abnormal 222.16 10.87 203 57557 31514 63399748
Drug intolerance 186.52 10.87 29 57731 308632 63122630
Alopecia 161.53 10.87 53 57707 337483 63093779
Contraindicated product administered 161.50 10.87 9 57751 217639 63213623
Synovitis 144.22 10.87 6 57754 186912 63244350
Systemic lupus erythematosus 142.47 10.87 13 57747 208905 63222357
Drug ineffective 139.04 10.87 488 57272 1044277 62386985
Pemphigus 138.16 10.87 7 57753 183719 63247543
Asthma-chronic obstructive pulmonary disease overlap syndrome 132.73 10.87 55 57705 2006 63429256
Glossodynia 130.84 10.87 8 57752 178868 63252394
Nasal congestion 124.17 10.87 218 57542 65442 63365820
Total lung capacity increased 123.43 10.87 54 57706 2256 63429006
Sputum discoloured 123.06 10.87 109 57651 16238 63415024
Arthropathy 121.14 10.87 32 57728 234760 63196502
Treatment failure 119.47 10.87 19 57741 199024 63232238
Bronchiectasis 118.28 10.87 106 57654 16036 63415226
Therapeutic product effect incomplete 116.86 10.87 312 57448 124744 63306518
Completed suicide 114.67 10.87 4 57756 145669 63285593
Respiratory failure 113.83 10.87 272 57488 101586 63329676
Rheumatoid arthritis 111.00 10.87 46 57714 253773 63177489
Cardiac murmur 109.48 10.87 97 57663 14455 63416807
Dyspnoea exertional 108.60 10.87 196 57564 60106 63371156
Nasal polyps 106.10 10.87 67 57693 5972 63425290
Breath sounds abnormal 104.95 10.87 84 57676 10889 63420373
Middle insomnia 104.66 10.87 89 57671 12554 63418708
Wound 104.02 10.87 13 57747 163250 63268012
Sleep apnoea syndrome 101.74 10.87 129 57631 29004 63402258
Loss of personal independence in daily activities 96.25 10.87 248 57512 97042 63334220
Bronchial neoplasm 91.96 10.87 29 57731 471 63430791
Nasal turbinate hypertrophy 91.29 10.87 32 57728 731 63430531
Joint swelling 90.32 10.87 99 57661 327567 63103695
Rales 90.31 10.87 82 57678 12615 63418647
Infusion related reaction 90.14 10.87 56 57704 245465 63185797
Gastrooesophageal reflux disease 88.70 10.87 238 57522 95401 63335861
Pericarditis 87.52 10.87 9 57751 131570 63299692
Bronchial haemorrhage 87.14 10.87 29 57731 563 63430699
Off label use 86.68 10.87 319 57441 674143 62757119
Vocal cord dysfunction 84.85 10.87 28 57732 529 63430733
Maternal exposure during pregnancy 83.86 10.87 48 57712 220014 63211248
Hyper IgE syndrome 83.19 10.87 27 57733 483 63430779
Blood test abnormal 83.05 10.87 86 57674 15543 63415719
Rhinitis allergic 81.97 10.87 75 57685 11652 63419610
Discomfort 80.45 10.87 26 57734 167348 63263914
Bronchitis 80.10 10.87 273 57487 124662 63306600
Toxicity to various agents 79.47 10.87 65 57695 247185 63184077
Abdominal discomfort 78.84 10.87 106 57654 320779 63110483
Rhonchi 78.70 10.87 41 57719 2535 63428727
Therapeutic product effect decreased 78.20 10.87 39 57721 193148 63238114
Ventricular failure 77.87 10.87 24 57736 360 63430902
Acute respiratory failure 77.86 10.87 124 57636 34361 63396901
Sarcoidosis 75.63 10.87 58 57702 7064 63424198
Respiration abnormal 74.22 10.87 55 57705 6362 63424900
Upper-airway cough syndrome 73.97 10.87 70 57690 11348 63419914
Blood immunoglobulin E increased 73.42 10.87 45 57715 3804 63427458
Endometrial ablation 73.34 10.87 29 57731 935 63430327
Arthralgia 72.76 10.87 270 57490 569440 62861822
Anti-cyclic citrullinated peptide antibody positive 72.22 10.87 10 57750 116202 63315060
Oesophageal spasm 71.30 10.87 41 57719 3082 63428180
Hypercapnia 70.68 10.87 50 57710 5381 63425881
Total lung capacity decreased 70.30 10.87 36 57724 2147 63429115
Prolonged expiration 69.74 10.87 29 57731 1067 63430195
Eosinophilia 68.98 10.87 94 57666 22662 63408600
Swelling 68.61 10.87 90 57670 275288 63155974
Pain 68.53 10.87 395 57365 740233 62691029
Bronchospasm 67.56 10.87 81 57679 17199 63414063
Haemoptysis 67.21 10.87 105 57655 28621 63402641
Hypoxia 67.11 10.87 160 57600 59632 63371630
Rhinitis 66.71 10.87 66 57694 11300 63419962
Helicobacter infection 65.34 10.87 5 57755 92780 63338482
Forced expiratory volume decreased 65.26 10.87 46 57714 4922 63426340
Bronchial disorder 65.19 10.87 29 57731 1261 63430001
Restrictive pulmonary disease 64.85 10.87 32 57728 1763 63429499
Upper respiratory tract infection 64.16 10.87 192 57568 81855 63349407
Rib deformity 63.25 10.87 19 57741 260 63431002
Oesophageal pain 62.37 10.87 40 57720 3661 63427601
Heart sounds 62.19 10.87 26 57734 970 63430292
Myocardial infarction 60.29 10.87 214 57546 99679 63331583
Rash 57.97 10.87 288 57472 560583 62870679
Bronchopulmonary aspergillosis allergic 57.93 10.87 32 57728 2226 63429036
Laryngeal stenosis 56.94 10.87 25 57735 1053 63430209
Throat clearing 55.87 10.87 32 57728 2387 63428875
Oxygen saturation decreased 54.51 10.87 191 57569 88394 63342868
Breast conserving surgery 54.35 10.87 24 57736 1025 63430237
Sinus disorder 53.66 10.87 87 57673 24466 63406796
Dysphonia 51.91 10.87 126 57634 47488 63383774
Exposure during pregnancy 51.06 10.87 40 57720 155507 63275755
Tachypnoea 50.22 10.87 70 57690 17232 63414030
Psoriatic arthropathy 50.04 10.87 11 57749 91509 63339753
Blister 48.45 10.87 29 57731 129785 63301477
Product use issue 48.12 10.87 79 57681 220441 63210821
PO2 decreased 46.09 10.87 24 57736 1482 63429780
Jaundice cholestatic 45.73 10.87 44 57716 7280 63423982
Hepatic enzyme increased 45.54 10.87 71 57689 202257 63229005
Irritable bowel syndrome 44.87 10.87 10 57750 82402 63348860
Lung neoplasm malignant 43.50 10.87 70 57690 19563 63411699
Lower respiratory tract infection 43.38 10.87 236 57524 132071 63299191
Hypomania 43.30 10.87 40 57720 6290 63424972
Lung opacity 43.17 10.87 30 57730 3138 63428124
Nasal obstruction 42.95 10.87 24 57736 1707 63429555
Sight disability 42.42 10.87 12 57748 131 63431131
PCO2 increased 41.55 10.87 21 57739 1218 63430044
Sinus tachycardia 41.29 10.87 77 57683 24191 63407071
Respiratory rate increased 40.79 10.87 56 57704 13592 63417670
Oedema peripheral 40.41 10.87 303 57457 189208 63242054
Respiratory disorder 40.04 10.87 101 57659 38981 63392281
Lymphoedema 39.59 10.87 51 57709 11641 63419621
Aspiration 39.39 10.87 49 57711 10802 63420460
Intentional product use issue 39.36 10.87 35 57725 127857 63303405
Venous pressure jugular increased 39.20 10.87 16 57744 561 63430701
Thermohypoaesthesia 38.73 10.87 11 57749 122 63431140
Influenza B virus test positive 38.70 10.87 13 57747 260 63431002
Lung hyperinflation 37.82 10.87 20 57740 1275 63429987
Cardiac failure congestive 37.42 10.87 175 57585 92258 63339004
Impaired healing 36.75 10.87 24 57736 102518 63328744
Granuloma 36.71 10.87 35 57725 5726 63425536
Reversible airways obstruction 36.32 10.87 22 57738 1820 63429442
Sleep disorder due to general medical condition, insomnia type 36.24 10.87 3 57757 52214 63379048
Infective exacerbation of chronic obstructive airways disease 35.54 10.87 19 57741 1238 63430024
Status asthmaticus 35.31 10.87 17 57743 887 63430375
Drug abuse 35.30 10.87 11 57749 72507 63358755
Blood insulin abnormal 35.18 10.87 8 57752 32 63431230
FEV1/FVC ratio decreased 34.96 10.87 10 57750 114 63431148
Tracheomalacia 34.36 10.87 11 57749 188 63431074
Pulmonary hypertension 34.00 10.87 92 57668 37031 63394231
Infective pulmonary exacerbation of cystic fibrosis 33.92 10.87 41 57719 8776 63422486
Airway peak pressure increased 33.87 10.87 12 57748 283 63430979
Respiratory distress 32.98 10.87 86 57674 33865 63397397
Dyslipidaemia 32.82 10.87 37 57723 7356 63423906
Multimorbidity 32.11 10.87 14 57746 580 63430682
Polycystic ovaries 32.04 10.87 29 57731 4442 63426820
Respiratory tract infection 31.40 10.87 96 57664 41387 63389875
Affective disorder 31.18 10.87 33 57727 6113 63425149
Heart rate increased 30.81 10.87 168 57592 94070 63337192
Pneumonia viral 30.74 10.87 37 57723 7885 63423377
Diarrhoea 30.47 10.87 463 57297 714903 62716359
Respiratory gas exchange disorder 30.37 10.87 12 57748 386 63430876
Depressive symptom 30.17 10.87 27 57733 4075 63427187
Skin lesion 30.03 10.87 78 57682 30643 63400619
Hip arthroplasty 29.83 10.87 4 57756 47642 63383620
Bundle branch block left 29.09 10.87 34 57726 7025 63424237
C-reactive protein abnormal 28.55 10.87 4 57756 46092 63385170
Schizophrenia 28.49 10.87 40 57720 9912 63421350
Coronary artery disease 27.44 10.87 78 57682 32299 63398963
Fatigue 27.42 10.87 608 57152 887420 62543842
Drug hypersensitivity 27.36 10.87 168 57592 310519 63120743
Atrial fibrillation 26.85 10.87 190 57570 116446 63314816
Red blood cell sedimentation rate increased 26.81 10.87 4 57756 43978 63387284
Gastrointestinal disorder 26.80 10.87 49 57711 131190 63300072
Lactose intolerance 26.79 10.87 22 57738 2956 63428306
Cyanosis 26.67 10.87 52 57708 16883 63414379
Asthmatic crisis 26.67 10.87 18 57742 1795 63429467
Liver injury 26.36 10.87 11 57749 60509 63370753
Separation anxiety disorder 26 10.87 6 57754 26 63431236
Chest X-ray abnormal 25.92 10.87 26 57734 4523 63426739
Kyphosis 25.48 10.87 20 57740 2520 63428742
Respiratory acidosis 25.47 10.87 31 57729 6684 63424578
Toxic epidermal necrolysis 25.46 10.87 65 57695 25269 63405993
Crystal arthropathy 25.18 10.87 10 57750 326 63430936
Blood pH decreased 25.15 10.87 20 57740 2567 63428695
Appetite disorder 24.89 10.87 32 57728 7289 63423973
Sinusitis 24.78 10.87 315 57445 226338 63204924
Liver disorder 24.63 10.87 9 57751 53678 63377584
Intentional overdose 24.41 10.87 19 57741 74133 63357129
Rhinorrhoea 24.26 10.87 121 57639 65456 63365806
Blood cholesterol increased 24.14 10.87 30 57730 94002 63337260
Haematoma 23.98 10.87 78 57682 34742 63396520
Heparin-induced thrombocytopenia 23.96 10.87 25 57735 4557 63426705
Unresponsive to stimuli 23.51 10.87 76 57684 33740 63397522
Knee arthroplasty 23.37 10.87 10 57750 54196 63377066
Abortion spontaneous 23.25 10.87 7 57753 47188 63384074
Blood bicarbonate decreased 22.91 10.87 20 57740 2921 63428341
Emphysema 22.88 10.87 38 57722 10900 63420362
Influenza 22.68 10.87 173 57587 108549 63322713
Acute generalised exanthematous pustulosis 22.47 10.87 38 57722 11061 63420201
Amaurosis 22.43 10.87 11 57749 598 63430664
Lung disorder 22.41 10.87 114 57646 62147 63369115
Febrile neutropenia 21.79 10.87 47 57713 118402 63312860
Pulmonary function test decreased 21.47 10.87 22 57738 3925 63427337
Rectal prolapse 20.73 10.87 16 57744 1967 63429295
Oesophageal motility disorder 20.52 10.87 9 57751 378 63430884
Brain hypoxia 20.52 10.87 10 57750 536 63430726
Peripheral swelling 20.31 10.87 150 57610 265792 63165470
Optic ischaemic neuropathy 20.08 10.87 13 57747 1209 63430053
Eosinophil count abnormal 19.82 10.87 10 57750 578 63430684
Blood lactic acid increased 19.57 10.87 28 57732 7058 63424204
Adverse event 19.02 10.87 20 57740 67539 63363723
Peak expiratory flow rate abnormal 18.94 10.87 6 57754 99 63431163
Stress cardiomyopathy 18.66 10.87 32 57728 9418 63421844
Angina pectoris 18.61 10.87 65 57695 30013 63401249
Mobility decreased 18.45 10.87 53 57707 121106 63310156
Frustration tolerance decreased 18.41 10.87 27 57733 6961 63424301
Pupillary reflex impaired 18.16 10.87 15 57745 2032 63429230
Upper airway obstruction 18.14 10.87 10 57750 693 63430569
Hypoventilation 18.11 10.87 22 57738 4732 63426530
Upper respiratory tract irritation 18.11 10.87 7 57753 212 63431050
Injection site reaction 18.02 10.87 16 57744 58508 63372754
Premature delivery 17.90 10.87 3 57757 30278 63400984
Humidity intolerance 17.85 10.87 8 57752 354 63430908
Blood calcium increased 17.60 10.87 31 57729 9319 63421943
Sneezing 17.54 10.87 46 57714 18172 63413090
Dystrophic calcification 17.50 10.87 6 57754 128 63431134
Pulmonary oedema 17.37 10.87 97 57663 54776 63376486
Infusion site erythema 17.36 10.87 35 57725 11644 63419618
Seasonal allergy 17.29 10.87 50 57710 20900 63410362
Pneumonia staphylococcal 17.21 10.87 17 57743 2903 63428359
Musculoskeletal stiffness 17.20 10.87 98 57662 184520 63246742
Presyncope 17.15 10.87 60 57700 27725 63403537
Neuromyelitis optica spectrum disorder 16.99 10.87 11 57749 1023 63430239
Pneumonia respiratory syncytial viral 16.84 10.87 11 57749 1039 63430223
Pulmonary mass 16.82 10.87 52 57708 22544 63408718
Chest pain 16.81 10.87 283 57477 215676 63215586
Nephrocalcinosis 16.57 10.87 11 57749 1067 63430195
Staphylococcus test positive 16.45 10.87 19 57741 3877 63427385
Psoriasis 16.42 10.87 34 57726 86923 63344339
Infusion site extravasation 16.40 10.87 32 57728 10394 63420868
Disease progression 16.37 10.87 57 57703 122701 63308561
Oropharyngeal discomfort 16.35 10.87 22 57738 5238 63426024
Forced expiratory volume increased 16.25 10.87 4 57756 24 63431238
Chronic sinusitis 16.20 10.87 36 57724 12807 63418455
Injection site pain 16.17 10.87 62 57698 129738 63301524
Injection site bruising 16.14 10.87 9 57751 41901 63389361
Nausea 15.57 10.87 628 57132 853843 62577419
Tinnitus 15.56 10.87 69 57691 35559 63395703
Infusion site haemorrhage 15.39 10.87 21 57739 5065 63426197
Decreased appetite 15.38 10.87 150 57610 250902 63180360
Malaise 15.15 10.87 490 57270 415464 63015798
Pancytopenia 15.05 10.87 42 57718 96891 63334371
Abscess 14.95 10.87 41 57719 16627 63414635
Idiopathic angioedema 14.64 10.87 4 57756 38 63431224
Extensor plantar response 14.63 10.87 11 57749 1300 63429962
Acute myocardial infarction 14.63 10.87 63 57697 32061 63399201
Respiratory alkalosis 14.59 10.87 15 57745 2686 63428576
Glycosylated haemoglobin decreased 14.46 10.87 8 57752 558 63430704
Stomatitis 14.39 10.87 71 57689 138654 63292608
Hepatic function abnormal 14.27 10.87 8 57752 37134 63394128
Respiratory tract congestion 14.18 10.87 42 57718 17790 63413472
Sputum purulent 14.13 10.87 10 57750 1077 63430185
Inflammation 14.03 10.87 34 57726 82239 63349023
Infusion site pruritus 14.03 10.87 22 57738 6013 63425249
White blood cell count decreased 13.97 10.87 72 57688 139032 63292230
Eye pruritus 13.93 10.87 43 57717 18628 63412634
Hypoaesthesia 13.81 10.87 93 57667 168300 63262962
Vascular parkinsonism 13.77 10.87 5 57755 127 63431135
Lactic acidosis 13.70 10.87 70 57690 38217 63393045
Eczema 13.70 10.87 62 57698 32229 63399033
Peak expiratory flow rate decreased 13.67 10.87 8 57752 621 63430641
Hyperlipidaemia 13.62 10.87 44 57716 19527 63411735
Foetal exposure during pregnancy 13.61 10.87 6 57754 31956 63399306
Idiopathic intracranial hypertension 13.58 10.87 15 57745 2916 63428346
Agitation 13.54 10.87 97 57663 59660 63371602
Type 2 diabetes mellitus 13.52 10.87 102 57658 63766 63367496
Tremor 13.27 10.87 181 57579 132058 63299204
Chondrocalcinosis pyrophosphate 13.26 10.87 10 57750 1188 63430074
Laryngospasm 13.18 10.87 15 57745 3013 63428249
Pneumonia haemophilus 13.15 10.87 8 57752 667 63430595
Multiple sclerosis relapse 12.93 10.87 15 57745 48463 63382799
Hypersensitivity 12.89 10.87 188 57572 292497 63138765
Hypertrophic cardiomyopathy 12.78 10.87 11 57749 1576 63429686
Anxiety 12.77 10.87 273 57487 217268 63213994
Pharyngeal mass 12.72 10.87 6 57754 299 63430963
Sedation 12.70 10.87 10 57750 38799 63392463
Cardiomegaly 12.62 10.87 40 57720 17574 63413688
C-reactive protein increased 12.61 10.87 44 57716 94663 63336599
Flank pain 12.44 10.87 38 57722 16372 63414890
Inspiratory capacity decreased 12.41 10.87 4 57756 70 63431192
Ankle fracture 12.30 10.87 40 57720 17815 63413447
Hyperlactacidaemia 12.21 10.87 14 57746 2835 63428427
Musculoskeletal pain 12.20 10.87 43 57717 92234 63339028
Visceral pain 12.19 10.87 3 57757 18 63431244
Blood glucose abnormal 12.15 10.87 24 57736 7868 63423394
Frequent bowel movements 12.12 10.87 3 57757 23019 63408243
Anaphylactic reaction 12.05 10.87 102 57658 65998 63365264
Blood albumin decreased 11.95 10.87 35 57725 14731 63416531
Vocal cord disorder 11.93 10.87 10 57750 1383 63429879
Infusion site bruising 11.87 10.87 16 57744 3816 63427446
Forced expiratory volume abnormal 11.82 10.87 4 57756 82 63431180
Pneumonia pseudomonal 11.80 10.87 13 57747 2520 63428742
Bone marrow failure 11.71 10.87 6 57754 29284 63401978
Facial discomfort 11.59 10.87 4 57756 87 63431175
Tachycardia 11.56 10.87 161 57599 117995 63313267
Generalised tonic-clonic seizure 11.51 10.87 6 57754 29010 63402252
Impaired quality of life 11.48 10.87 33 57727 13750 63417512
Pulmonary pain 11.47 10.87 15 57745 3475 63427787
Restless legs syndrome 11.42 10.87 40 57720 18491 63412771
Pulmonary embolism 11.42 10.87 159 57601 116525 63314737
Angle closure glaucoma 11.41 10.87 12 57748 2207 63429055
Fluid retention 11.35 10.87 93 57667 59593 63371669
Foreign body sensation in eyes 11.34 10.87 12 57748 2222 63429040
Drug eruption 11.29 10.87 6 57754 28688 63402574
Breathing-related sleep disorder 11.26 10.87 4 57756 95 63431167
Cardiac disorder 11.23 10.87 82 57678 50734 63380528
Hiatus hernia 11.13 10.87 44 57716 21550 63409712
Barrett's oesophagus 11.04 10.87 7 57753 628 63430634
Tongue exfoliation 11.00 10.87 4 57756 102 63431160
Prescribed overdose 10.92 10.87 9 57751 34144 63397118
Tumour hyperprogression 10.89 10.87 4 57756 105 63431157

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 699.67 11.82 511 43180 42145 34871095
Wheezing 548.83 11.82 437 43254 40965 34872275
Chronic obstructive pulmonary disease 467.56 11.82 428 43263 48490 34864750
Obstructive airways disorder 453.62 11.82 267 43424 15227 34898013
Dyspnoea 330.60 11.82 1125 42566 375657 34537583
Asthma-chronic obstructive pulmonary disease overlap syndrome 269.88 11.82 89 43602 1198 34912042
Appendicolith 240.62 11.82 144 43547 8457 34904783
Full blood count abnormal 193.19 11.82 171 43520 18497 34894743
Appendicitis 182.58 11.82 150 43541 14657 34898583
Stress 174.09 11.82 202 43489 30145 34883095
Sputum discoloured 168.71 11.82 111 43580 7701 34905539
Cardiogenic shock 154.05 11.82 178 43513 26440 34886800
Cough 151.95 11.82 472 43219 149668 34763572
Bronchiectasis 135.09 11.82 106 43585 9695 34903545
Nasal obstruction 126.60 11.82 43 43648 637 34912603
Chest discomfort 125.60 11.82 236 43455 54294 34858946
Productive cough 123.25 11.82 191 43500 37622 34875618
Pulmonary function test decreased 120.52 11.82 76 43615 4899 34908341
Sinus pain 119.93 11.82 42 43649 685 34912555
Pneumonia 112.09 11.82 805 42886 361822 34551418
Ventricular fibrillation 110.75 11.82 140 43551 22814 34890426
Fractional exhaled nitric oxide increased 110.60 11.82 44 43647 1038 34912202
Blood phosphorus increased 101.03 11.82 81 43610 7640 34905600
Forced expiratory volume decreased 93.15 11.82 55 43636 3148 34910092
Eosinophilia 91.86 11.82 137 43554 26085 34887155
Drug abuse 86.37 11.82 11 43680 99085 34814155
Toxicity to various agents 85.35 11.82 75 43616 200287 34712953
Toxic epidermal necrolysis 84.42 11.82 119 43572 21527 34891713
Completed suicide 82.94 11.82 12 43679 98156 34815084
Lower respiratory tract infection 81.78 11.82 144 43547 31493 34881747
Mycobacterium avium complex infection 80.67 11.82 46 43645 2465 34910775
Plantar fasciitis 79.58 11.82 43 43648 2073 34911167
Multiple organ dysfunction syndrome 75.69 11.82 239 43452 76327 34836913
Emphysema 73.16 11.82 74 43617 9451 34903789
Myoglobin blood increased 72.77 11.82 46 43645 2977 34910263
Nasal congestion 71.67 11.82 114 43577 22943 34890297
Sensation of foreign body 71.15 11.82 44 43647 2739 34910501
Dyspnoea exertional 69.92 11.82 162 43529 43117 34870123
Bronchitis 69.92 11.82 159 43532 41804 34871436
Middle insomnia 69.72 11.82 62 43629 6740 34906500
Abdominal distension 69.59 11.82 195 43496 58297 34854943
Therapeutic product effect incomplete 68.69 11.82 177 43514 50364 34862876
Ascites 67.36 11.82 167 43524 46404 34866836
Brain natriuretic peptide increased 62.87 11.82 54 43637 5605 34907635
Secretion discharge 60.87 11.82 54 43637 5851 34907389
Oxygen saturation decreased 60.69 11.82 176 43515 53642 34859598
Lung consolidation 60.63 11.82 54 43637 5882 34907358
Respiratory distress 60.37 11.82 136 43555 35529 34877711
General physical health deterioration 59.03 11.82 316 43375 127953 34785287
Osteopenia 57.41 11.82 48 43643 4801 34908439
Respiratory failure 55.16 11.82 275 43416 108297 34804943
Sleep disorder due to a general medical condition 54.33 11.82 48 43643 5173 34908067
Respiratory disorder 54.12 11.82 91 43600 19173 34894067
Hyponatraemia 48.96 11.82 219 43472 82472 34830768
Painful respiration 48.96 11.82 26 43665 1210 34912030
Pulmonary function test abnormal 46.64 11.82 33 43658 2577 34910663
Myasthenia gravis 46.28 11.82 50 43641 6890 34906350
Eye disorder 44.18 11.82 57 43634 9471 34903769
Dry mouth 43.42 11.82 108 43583 30057 34883183
Throat irritation 42.46 11.82 59 43632 10526 34902714
Bronchial hyperreactivity 41.12 11.82 26 43665 1683 34911557
Blood uric acid increased 40.65 11.82 55 43636 9569 34903671
Tachypnoea 40.44 11.82 78 43613 18274 34894966
Chest injury 40.28 11.82 25 43666 1566 34911674
Diarrhoea 39.78 11.82 305 43386 389607 34523633
Pneumothorax 39.47 11.82 79 43612 19013 34894227
Pulmonary mass 37.97 11.82 62 43629 12750 34900490
Pleural thickening 37.08 11.82 15 43676 370 34912870
Bronchospasm 36.05 11.82 55 43636 10676 34902564
Pneumonitis 34.58 11.82 107 43584 33771 34879469
Exostosis 33.21 11.82 35 43656 4688 34908552
Constipation 33.15 11.82 288 43403 136694 34776546
Dysphonia 31.86 11.82 82 43609 23301 34889939
Drug therapy 31.63 11.82 19 43672 1122 34912118
Genital herpes simplex 31.44 11.82 10 43681 119 34913121
Foetal exposure during pregnancy 31.37 11.82 5 43686 38096 34875144
Walking aid user 31.35 11.82 23 43668 1901 34911339
Analgesic therapy 31.30 11.82 18 43673 980 34912260
Hypoventilation 30.85 11.82 29 43662 3385 34909855
Overdose 30.00 11.82 42 43649 91017 34822223
Diaphragmatic disorder 29.69 11.82 19 43672 1256 34911984
Hyperkaliuria 29.27 11.82 9 43682 95 34913145
Lung disorder 27.80 11.82 101 43590 34595 34878645
Sensitivity to weather change 27.77 11.82 20 43671 1606 34911634
Febrile neutropenia 25.99 11.82 86 43605 136763 34776477
White blood cell count decreased 25.87 11.82 50 43641 95395 34817845
Neuropathy peripheral 25.87 11.82 40 43651 83223 34830017
Malignant neoplasm progression 25.76 11.82 44 43647 88002 34825238
Use of accessory respiratory muscles 25.76 11.82 12 43679 420 34912820
Sleep disorder therapy 25.71 11.82 16 43675 1007 34912233
Total lung capacity abnormal 25.52 11.82 9 43682 150 34913090
Hypercapnia 25.51 11.82 29 43662 4226 34909014
Seasonal allergy 24.99 11.82 36 43655 6639 34906601
Hyperphosphataemia 24.53 11.82 29 43662 4408 34908832
Bronchitis viral 24.37 11.82 10 43681 256 34912984
Upper-airway cough syndrome 24.37 11.82 26 43665 3532 34909708
COVID-19 treatment 23.95 11.82 10 43681 268 34912972
Oral candidiasis 23.71 11.82 49 43642 12061 34901179
Ocular discomfort 22.97 11.82 20 43671 2114 34911126
Platelet count decreased 22.89 11.82 75 43616 119642 34793598
Breath sounds abnormal 22.73 11.82 35 43656 6846 34906394
Wolff-Parkinson-White syndrome 22.44 11.82 9 43682 217 34913023
Lung hyperinflation 22.43 11.82 14 43677 886 34912354
Iron deficiency 21.59 11.82 30 43661 5351 34907889
Off label use 21.59 11.82 382 43309 419142 34494098
Intentional overdose 21.56 11.82 14 43677 43660 34869580
Bronchial wall thickening 21.49 11.82 16 43675 1352 34911888
Drug ineffective 21.31 11.82 423 43268 456328 34456912
Hypoxia 20.88 11.82 129 43562 54966 34858274
Chronic respiratory failure 20.87 11.82 16 43675 1413 34911827
Influenza 20.56 11.82 119 43572 49547 34863693
Treatment failure 20.42 11.82 17 43674 46680 34866560
Blood immunoglobulin E decreased 20.37 11.82 6 43685 54 34913186
Aortic aneurysm 20.35 11.82 33 43658 6746 34906494
Type IIa hyperlipidaemia 20.06 11.82 8 43683 190 34913050
Blood immunoglobulin E increased 19.95 11.82 20 43671 2526 34910714
Dust allergy 19.86 11.82 13 43678 893 34912347
Rash 19.58 11.82 181 43510 222571 34690669
Inappropriate schedule of product administration 19.28 11.82 30 43661 62266 34850974
Hypohidrosis 19.24 11.82 8 43683 212 34913028
Neutropenia 19.21 11.82 116 43575 156662 34756578
Forced vital capacity decreased 19.16 11.82 12 43679 764 34912476
Incorrect route of product administration 19.13 11.82 51 43640 14794 34898446
Peak expiratory flow rate decreased 19.05 11.82 7 43684 132 34913108
Illness 19.00 11.82 48 43643 13481 34899759
Respiratory tract infection 18.96 11.82 61 43630 19651 34893589
Infective pulmonary exacerbation of cystic fibrosis 18.93 11.82 32 43659 6769 34906471
Tachycardia foetal 18.83 11.82 9 43682 334 34912906
Genital herpes 18.71 11.82 11 43680 624 34912616
Respiratory tract congestion 18.58 11.82 30 43661 6109 34907131
Respiratory acidosis 18.56 11.82 27 43664 5023 34908217
Aggression 18.55 11.82 13 43678 38951 34874289
Feeling cold 18.47 11.82 41 43650 10598 34902642
Disease progression 18.46 11.82 71 43620 108006 34805234
Rales 18.20 11.82 39 43652 9844 34903396
Atrial fibrillation 18.09 11.82 233 43458 122160 34791080
Drug resistance 18.07 11.82 5 43686 25922 34887318
Cardiac disorder 17.63 11.82 103 43588 43023 34870217
Blood cholesterol increased 17.48 11.82 61 43630 20482 34892758
Suicide attempt 17.40 11.82 14 43677 39102 34874138
Bilirubin conjugated abnormal 16.69 11.82 6 43685 106 34913134
Perfume sensitivity 16.59 11.82 6 43685 108 34913132
Haemoptysis 16.57 11.82 87 43604 34919 34878321
Sneezing 16.39 11.82 26 43665 5216 34908024
Diastolic hypotension 16.33 11.82 5 43686 52 34913188
Left ventricular hypertrophy 16.04 11.82 33 43658 8097 34905143
Bronchospasm paradoxical 15.91 11.82 5 43686 57 34913183
Reversible airways obstruction 15.82 11.82 9 43682 480 34912760
Sepsis 15.75 11.82 294 43397 166267 34746973
Injection related reaction 15.60 11.82 8 43683 346 34912894
Multiple allergies 15.57 11.82 19 43672 2984 34910256
Carbon dioxide increased 15.56 11.82 12 43679 1069 34912171
Back injury 15.43 11.82 22 43669 4019 34909221
Pancreatitis acute 15.33 11.82 8 43683 28133 34885107
Viral myelitis 15.32 11.82 5 43686 65 34913175
Headache 15.15 11.82 169 43522 200466 34712774
Ischaemic cardiomyopathy 15.12 11.82 28 43663 6361 34906879
Vital capacity decreased 14.83 11.82 8 43683 384 34912856
Conjunctivitis allergic 14.72 11.82 12 43679 1158 34912082
Product prescribing error 14.52 11.82 62 43629 22865 34890375
Occupational exposure to air contaminants 14.47 11.82 6 43685 158 34913082
Pruritus 14.43 11.82 111 43580 141870 34771370
Memory impairment 14.24 11.82 20 43671 43298 34869942
Fatigue 13.91 11.82 355 43336 370298 34542942
Respiratory rate increased 13.79 11.82 35 43656 9859 34903381
Psoriasis 13.70 11.82 17 43674 38795 34874445
Toxic optic neuropathy 13.48 11.82 10 43681 840 34912400
Cytomegalovirus infection 13.42 11.82 8 43683 26127 34887113
Acute respiratory failure 13.38 11.82 75 43616 30853 34882387
Pain 13.33 11.82 178 43513 204497 34708743
Premature baby 13.29 11.82 4 43687 19629 34893611
Cytokine release syndrome 13.23 11.82 6 43685 22871 34890369
Bone marrow oedema 13.19 11.82 9 43682 663 34912577
Status asthmaticus 13.14 11.82 7 43684 328 34912912
Subcutaneous emphysema 12.47 11.82 11 43680 1183 34912057
Medication error 12.42 11.82 64 43627 25501 34887739
Therapeutic response decreased 12.41 11.82 11 43680 29302 34883938
Lung opacity 12.35 11.82 15 43676 2344 34910896
Mycobacterial infection 12.28 11.82 15 43676 2359 34910881
Hyperaesthesia teeth 12.16 11.82 8 43683 554 34912686
Expiratory reserve volume decreased 12.05 11.82 4 43687 55 34913185
Cardiomyopathy 11.86 11.82 47 43644 16761 34896479
Gastrointestinal disorder 11.84 11.82 15 43676 33933 34879307

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 1620.56 10.55 1263 84523 133832 79524770
Wheezing 1072.03 10.55 935 84851 115729 79542873
Obstructive airways disorder 870.78 10.55 496 85290 30963 79627639
Chronic obstructive pulmonary disease 846.12 10.55 715 85071 84704 79573898
Dyspnoea 599.62 10.55 2148 83638 854877 78803725
Full blood count abnormal 376.33 10.55 327 85459 40147 79618455
Asthma-chronic obstructive pulmonary disease overlap syndrome 352.05 10.55 132 85654 3089 79655513
Productive cough 348.69 10.55 452 85334 87879 79570723
Cough 336.09 10.55 1010 84776 365779 79292823
Pneumonia 322.54 10.55 1483 84303 658763 78999839
Chest discomfort 258.67 10.55 502 85284 137542 79521060
Appendicolith 258.66 10.55 143 85643 8408 79650194
Sputum discoloured 248.49 10.55 198 85588 21545 79637057
Bronchiectasis 237.10 10.55 195 85591 22191 79636411
Completed suicide 225.35 10.55 9 85777 245758 79412844
Sleep disorder due to a general medical condition 209.59 10.55 151 85635 14126 79644476
Middle insomnia 193.66 10.55 151 85635 15918 79642684
Toxicity to various agents 169.33 10.55 124 85662 421416 79237186
Nasal congestion 166.59 10.55 297 85489 76255 79582347
Appendicitis 163.65 10.55 153 85633 20641 79637961
Forced expiratory volume decreased 141.40 10.55 94 85692 7720 79650882
Synovitis 130.22 10.55 8 85778 150726 79507876
Dyspnoea exertional 128.24 10.55 287 85499 86786 79571816
Respiratory failure 124.73 10.55 453 85333 180458 79478144
Lower respiratory tract infection 121.86 10.55 360 85426 128860 79529742
Nasal obstruction 121.27 10.55 55 85731 2109 79656493
Bronchitis 120.38 10.55 361 85425 130283 79528319
Stress 120.16 10.55 265 85521 79347 79579255
Cardiogenic shock 118.55 10.55 183 85603 41731 79616871
Drug abuse 116.22 10.55 18 85768 162673 79495929
Pulmonary function test decreased 114.90 10.55 82 85704 7555 79651047
Breath sounds abnormal 113.25 10.55 111 85675 15873 79642729
Therapeutic product effect incomplete 112.68 10.55 372 85414 141273 79517329
Total lung capacity increased 111.94 10.55 53 85733 2245 79656357
Alopecia 108.08 10.55 57 85729 231298 79427304
Eosinophilia 107.84 10.55 183 85603 45162 79613440
Toxic epidermal necrolysis 104.81 10.55 179 85607 44402 79614200
Drug intolerance 104.26 10.55 79 85707 264040 79394562
Systemic lupus erythematosus 100.09 10.55 8 85778 121141 79537461
Nasal polyps 99.63 10.55 74 85712 7253 79651349
Treatment failure 97.43 10.55 31 85755 170455 79488147
Oxygen saturation decreased 97.40 10.55 333 85453 128714 79529888
Ventricular fibrillation 96.82 10.55 144 85642 31782 79626820
Upper-airway cough syndrome 95.80 10.55 88 85698 11605 79646997
Hand deformity 94.54 10.55 4 85782 103915 79554687
Infusion related reaction 93.27 10.55 67 85719 230170 79428432
Nasal turbinate hypertrophy 91.82 10.55 33 85753 682 79657920
Respiratory distress 91.21 10.55 197 85589 58142 79600460
Blood phosphorus increased 90.92 10.55 81 85705 10266 79648336
Arthropathy 89.80 10.55 39 85747 177072 79481530
Rales 89.42 10.55 109 85677 19892 79638710
Blood immunoglobulin E increased 88.13 10.55 63 85723 5819 79652783
Drug ineffective 88.06 10.55 743 85043 1080170 78578432
Cardiac murmur 87.12 10.55 96 85690 15728 79642874
Bronchial neoplasm 86.73 10.55 29 85757 479 79658123
Rheumatoid arthritis 86.64 10.55 59 85727 208411 79450191
Pericarditis 85.78 10.55 7 85779 104229 79554373
Off label use 85.38 10.55 599 85187 906616 78751986
Bronchospasm 82.47 10.55 117 85669 24742 79633860
Glossodynia 82.18 10.55 8 85778 103329 79555273
Sleep apnoea syndrome 81.22 10.55 143 85643 36335 79622267
Joint swelling 80.52 10.55 116 85670 288530 79370072
Blood test abnormal 79.96 10.55 97 85689 17613 79640989
Hypercapnia 78.62 10.55 70 85716 8865 79649737
Pemphigus 78.43 10.55 8 85778 99574 79559028
Gastrooesophageal reflux disease 77.77 10.55 268 85518 103978 79554624
Vocal cord dysfunction 77.54 10.55 28 85758 587 79658015
Tachypnoea 77.03 10.55 130 85656 31933 79626669
Respiratory disorder 76.55 10.55 157 85629 44699 79613903
Acute respiratory failure 76.42 10.55 186 85600 59355 79599247
Hypoxia 75.78 10.55 264 85522 102979 79555623
Hyper IgE syndrome 75.76 10.55 27 85759 544 79658058
Haemoptysis 74.09 10.55 177 85609 55822 79602780
Oesophageal spasm 73.44 10.55 46 85740 3410 79655192
Total lung capacity decreased 72.87 10.55 43 85743 2862 79655740
Therapeutic product effect decreased 72.71 10.55 43 85743 163820 79494782
Contraindicated product administered 71.82 10.55 40 85746 157498 79501104
Rhonchi 71.69 10.55 48 85738 3988 79654614
Arthralgia 71.05 10.55 345 85441 571458 79087144
Pain 70.96 10.55 455 85331 703347 78955255
Endometrial ablation 70.78 10.55 29 85757 864 79657738
Respiration abnormal 70.49 10.55 62 85724 7726 79650876
Ventricular failure 69.41 10.55 25 85761 520 79658082
Restrictive pulmonary disease 69.29 10.55 40 85746 2555 79656047
Multiple organ dysfunction syndrome 68.05 10.55 283 85503 119963 79538639
Bronchopulmonary aspergillosis allergic 63.19 10.55 40 85746 3021 79655581
Bronchial haemorrhage 62.94 10.55 30 85756 1290 79657312
Rash 61.83 10.55 367 85419 577991 79080611
Emphysema 60.51 10.55 81 85705 16219 79642383
Rhinitis allergic 60.01 10.55 70 85716 12199 79646403
Upper respiratory tract infection 59.17 10.55 224 85562 90944 79567658
Heart sounds 58.75 10.55 26 85760 940 79657662
Prolonged expiration 57.91 10.55 28 85758 1243 79657359
Oesophageal pain 57.69 10.55 43 85743 4236 79654366
Diarrhoea 57.64 10.55 638 85148 879851 78778751
Lung hyperinflation 55.97 10.55 31 85755 1828 79656774
Rib deformity 54.87 10.55 17 85769 217 79658385
Helicobacter infection 53.86 10.55 6 85780 69698 79588904
Breast conserving surgery 53.71 10.55 23 85763 767 79657835
Duodenal ulcer perforation 52.97 10.55 5 85781 66206 79592396
Mycobacterium avium complex infection 52.78 10.55 42 85744 4558 79654044
Laryngeal stenosis 52.71 10.55 25 85761 1063 79657539
Pulmonary function test abnormal 52.23 10.55 40 85746 4104 79654498
Wound 52.23 10.55 30 85756 116149 79542453
Abdominal discomfort 51.86 10.55 121 85665 250606 79407996
Maternal exposure during pregnancy 51.12 10.55 43 85743 136495 79522107
Respiratory rate increased 51.12 10.55 87 85699 21513 79637089
Lung opacity 50.49 10.55 43 85743 5131 79653471
Sarcoidosis 50.15 10.55 53 85733 8282 79650320
Bronchial disorder 50.07 10.55 32 85754 2457 79656145
Blister 49.37 10.55 34 85752 119442 79539160
Rhinitis 48.10 10.55 69 85717 14738 79643864
Product use issue 46.89 10.55 97 85689 209725 79448877
Ascites 46.04 10.55 182 85604 75380 79583222
Hypoventilation 45.37 10.55 47 85739 7177 79651425
Loss of personal independence in daily activities 45.01 10.55 224 85562 102356 79556246
Pneumonitis 44.10 10.55 155 85631 60705 79597897
Intentional overdose 43.98 10.55 30 85756 105930 79552672
Throat clearing 43.42 10.55 30 85756 2624 79655978
Influenza 42.79 10.55 262 85524 129344 79529258
Sinus pain 42.58 10.55 34 85752 3708 79654894
Lung consolidation 42.02 10.55 50 85736 8897 79649705
Status asthmaticus 41.81 10.55 21 85765 1013 79657589
Reversible airways obstruction 41.37 10.55 27 85759 2149 79656453
Febrile neutropenia 41.24 10.55 120 85666 230879 79427723
Myasthenia gravis 40.64 10.55 53 85733 10346 79648256
Respiratory tract infection 40.59 10.55 130 85656 48559 79610043
Infective pulmonary exacerbation of cystic fibrosis 40.45 10.55 59 85727 12792 79645810
PCO2 increased 40.39 10.55 25 85761 1815 79656787
Hepatic enzyme increased 40.31 10.55 85 85701 182525 79476077
Bronchial hyperreactivity 39.76 10.55 30 85756 3010 79655592
Respiratory acidosis 39.06 10.55 54 85732 11146 79647456
Psoriatic arthropathy 38.23 10.55 18 85768 77981 79580621
Hyponatraemia 38.10 10.55 324 85462 177524 79481078
Muscle injury 37.98 10.55 4 85782 48557 79610045
Abdominal distension 37.69 10.55 239 85547 119411 79539191
Sinus disorder 37.58 10.55 78 85708 22386 79636216
Seasonal allergy 37.40 10.55 65 85721 16341 79642261
Lung neoplasm malignant 36.92 10.55 88 85698 27704 79630898
Lung disorder 36.83 10.55 178 85608 80379 79578223
Oedema peripheral 36.70 10.55 424 85362 251864 79406738
COVID-19 treatment 36.36 10.55 15 85771 455 79658147
Dysphonia 36.29 10.55 139 85647 56733 79601869
Sight disability 36.12 10.55 11 85775 132 79658470
Irritable bowel syndrome 36.11 10.55 11 85775 62230 79596372
PO2 decreased 36.03 10.55 28 85758 2935 79655667
Pulmonary mass 35.45 10.55 89 85697 28945 79629657
Red blood cell sedimentation rate increased 35.38 10.55 4 85782 45938 79612664
Neuropathy peripheral 35.36 10.55 61 85725 141244 79517358
Overdose 34.87 10.55 93 85693 184113 79474489
Impaired healing 34.83 10.55 26 85760 87629 79570973
Blood uric acid increased 34.55 10.55 56 85730 13304 79645298
Painful respiration 34.31 10.55 29 85757 3424 79655178
Intentional product use issue 34.25 10.55 70 85716 152042 79506560
Exposure during pregnancy 34.13 10.55 35 85751 101097 79557505
Polycystic ovaries 34.03 10.55 30 85756 3749 79654853
Diaphragmatic disorder 33.97 10.55 22 85764 1728 79656874
Aspiration 33.73 10.55 70 85716 20088 79638514
Analgesic therapy 33.64 10.55 18 85768 991 79657611
Thermohypoaesthesia 33.47 10.55 10 85776 112 79658490
Drug therapy 33.37 10.55 19 85767 1182 79657420
Chest injury 32.89 10.55 26 85760 2795 79655807
Drug-induced liver injury 32.80 10.55 15 85771 66102 79592500
Influenza B virus test positive 32.32 10.55 13 85773 369 79658233
Sinus tachycardia 31.18 10.55 99 85687 36809 79621793
Peak expiratory flow rate decreased 30.98 10.55 15 85771 668 79657934
Fatigue 30.71 10.55 764 85022 928963 78729639
Lymphoedema 30.70 10.55 51 85735 12362 79646240
Cyanosis 30.54 10.55 77 85709 25105 79633497
Airway peak pressure increased 30.05 10.55 12 85774 334 79658268
Discomfort 29.84 10.55 56 85730 125561 79533041
Sneezing 29.09 10.55 65 85721 19618 79638984
Swelling 29.06 10.55 127 85659 216584 79442018
Hyperphosphataemia 28.91 10.55 35 85751 6341 79652261
Hypomania 28.79 10.55 38 85748 7506 79651096
White blood cell count decreased 27.97 10.55 106 85680 188182 79470420
Sleep disorder therapy 27.92 10.55 16 85770 1008 79657594
Respiratory gas exchange disorder 27.86 10.55 15 85771 836 79657766
Hip arthroplasty 27.82 10.55 3 85783 35753 79622849
Kyphosis 27.57 10.55 23 85763 2668 79655934
Heart rate increased 27.48 10.55 223 85563 120501 79538101
Frustration tolerance decreased 27.42 10.55 37 85749 7465 79651137
Drug resistance 27.28 10.55 6 85780 42207 79616395
Cardiac failure congestive 27.18 10.55 253 85533 142149 79516453
Aortic aneurysm 26.91 10.55 39 85747 8407 79650195
Gastrointestinal disorder 26.86 10.55 57 85729 122148 79536454
Disease progression 26.60 10.55 105 85681 184257 79474345
Venous pressure jugular increased 26.39 10.55 17 85769 1323 79657279
Atrial fibrillation 26.32 10.55 327 85459 197559 79461043
Platelet count decreased 26.14 10.55 114 85672 194550 79464052
Hyperkaliuria 25.84 10.55 9 85777 169 79658433
Liver disorder 25.66 10.55 24 85762 72393 79586209
C-reactive protein abnormal 25.55 10.55 10 85776 48357 79610245
Pulmonary hypertension 25.51 10.55 111 85675 47969 79610633
Chronic respiratory failure 25.25 10.55 23 85763 2999 79655603
General physical health deterioration 25.16 10.55 426 85360 274812 79383790
Constipation 24.76 10.55 435 85351 282615 79375987
Wolff-Parkinson-White syndrome 24.56 10.55 10 85776 293 79658309
Pneumonia viral 24.52 10.55 39 85747 9119 79649483
Asthmatic crisis 24.49 10.55 19 85767 1987 79656615
Separation anxiety disorder 24.30 10.55 6 85780 30 79658572
Lactose intolerance 24.05 10.55 20 85766 2310 79656292
Psoriasis 23.97 10.55 37 85749 89550 79569052
Sensitivity to weather change 23.97 10.55 36 85750 8011 79650591
Multiple sclerosis relapse 23.96 10.55 10 85776 46523 79612079
Headache 23.54 10.55 530 85256 653242 79005360
Jaundice cholestatic 23.53 10.55 43 85743 11241 79647361
FEV1/FVC ratio decreased 23.52 10.55 9 85777 223 79658379
Suicide attempt 23.41 10.55 33 85753 82899 79575703
Respiratory tract congestion 23.15 10.55 60 85726 19894 79638708
Granuloma 23.14 10.55 36 85750 8261 79650341
Affective disorder 23.06 10.55 36 85750 8283 79650319
C-reactive protein increased 23.03 10.55 67 85719 128960 79529642
Genital herpes simplex 22.31 10.55 10 85776 373 79658229
Type IIa hyperlipidaemia 22.23 10.55 9 85777 260 79658342
Neutropenia 21.81 10.55 201 85585 287509 79371093
Sputum purulent 21.49 10.55 15 85771 1334 79657268
Eosinophil count increased 21.48 10.55 53 85733 17052 79641550
Peripheral swelling 21.47 10.55 186 85600 269431 79389171
Dyslipidaemia 21.37 10.55 42 85744 11591 79647011
Malignant neoplasm progression 21.21 10.55 75 85711 135915 79522687
Palmar-plantar erythrodysaesthesia syndrome 20.83 10.55 5 85781 33129 79625473
Injection site bruising 20.81 10.55 9 85777 40993 79617609
Hypoaesthesia 20.61 10.55 111 85675 179241 79479361
Drug ineffective for unapproved indication 20.61 10.55 15 85771 51223 79607379
Sepsis 20.41 10.55 405 85381 269023 79389579
Inflammation 20.38 10.55 44 85742 93709 79564893
Myelosuppression 20.21 10.55 9 85777 40287 79618315
Adverse event 20.13 10.55 21 85765 60193 79598409
Osteopenia 20.06 10.55 54 85732 18310 79640292
Decreased appetite 20.02 10.55 254 85532 342164 79316438
Blood pH decreased 19.97 10.55 25 85761 4686 79653916
Eye disorder 19.96 10.55 63 85723 23349 79635253
Hepatic function abnormal 19.75 10.55 30 85756 73077 79585525
Dust allergy 19.74 10.55 15 85771 1521 79657081
Blood calcium increased 19.66 10.55 38 85748 10362 79648240
Use of accessory respiratory muscles 19.27 10.55 10 85776 517 79658085
Cytomegalovirus infection 19.17 10.55 11 85775 42633 79615969
Iron deficiency 19.01 10.55 38 85748 10616 79647986
Obstruction 18.80 10.55 24 85762 4586 79654016
Bronchospasm paradoxical 18.70 10.55 7 85779 163 79658439
Injection site pain 18.69 10.55 74 85712 129764 79528838
Colitis ischaemic 18.66 10.55 47 85739 15312 79643290
Musculoskeletal stiffness 18.66 10.55 111 85675 174897 79483705
Humidity intolerance 18.65 10.55 9 85777 398 79658204
Oral candidiasis 18.56 10.55 72 85714 29556 79629046
Injection site erythema 18.44 10.55 35 85751 78162 79580440
Cor pulmonale 18.44 10.55 17 85769 2251 79656351
Injection site reaction 18.44 10.55 19 85767 54766 79603836
Ischaemic cardiomyopathy 18.21 10.55 31 85755 7664 79650938
Suicidal ideation 18.15 10.55 34 85752 76306 79582296
Bundle branch block left 18.13 10.55 39 85747 11474 79647128
Rhinorrhoea 18.11 10.55 142 85644 75932 79582670
Hypohidrosis 18.08 10.55 8 85778 289 79658313
Forced vital capacity decreased 18.07 10.55 15 85771 1728 79656874
Mobility decreased 17.99 10.55 69 85717 122106 79536496
Peak expiratory flow rate abnormal 17.89 10.55 6 85780 100 79658502
Stomatitis 17.89 10.55 89 85697 146668 79511934
Heparin-induced thrombocytopenia 17.84 10.55 35 85751 9647 79648955
Pneumonia staphylococcal 17.75 10.55 24 85762 4850 79653752
Basal cell carcinoma 17.74 10.55 9 85777 37366 79621236
Pancytopenia 17.73 10.55 105 85681 165640 79492962
Subcutaneous emphysema 17.69 10.55 15 85771 1779 79656823
Sopor 17.15 10.55 7 85779 33003 79625599
Rectal prolapse 17.08 10.55 16 85770 2162 79656440
Knee arthroplasty 16.96 10.55 13 85773 43235 79615367
Viral myelitis 16.92 10.55 6 85780 119 79658483
Bilirubin conjugated abnormal 16.88 10.55 6 85780 120 79658482
Long QT syndrome 16.83 10.55 26 85760 5929 79652673
Myocardial infarction 16.81 10.55 285 85501 183844 79474758
Appetite disorder 16.79 10.55 30 85756 7709 79650893
Depressive symptom 16.71 10.55 27 85759 6396 79652206
Carbon dioxide increased 16.70 10.55 16 85770 2224 79656378
Tachycardia 16.54 10.55 276 85510 177492 79481110
Total lung capacity abnormal 16.47 10.55 7 85779 229 79658373
Chest X-ray abnormal 16.39 10.55 30 85756 7853 79650749
Sedation 16.36 10.55 19 85767 51876 79606726
Tracheomalacia 16.32 10.55 8 85778 366 79658236
Dystrophic calcification 16.30 10.55 6 85780 133 79658469
Injection site swelling 16.26 10.55 16 85770 47116 79611486
Bronchial wall thickening 16.26 10.55 17 85769 2624 79655978
Generalised tonic-clonic seizure 16.22 10.55 14 85772 43896 79614706
Multimorbidity 16.21 10.55 13 85773 1426 79657176
Brain hypoxia 16.03 10.55 11 85775 952 79657650
Eosinophil count abnormal 15.97 10.55 10 85776 741 79657861
Dry eye 15.94 10.55 10 85776 36921 79621681
Sinusitis 15.86 10.55 297 85489 195204 79463398
Malaise 15.86 10.55 661 85125 489208 79169394
Premature delivery 15.86 10.55 3 85783 23464 79635138
Frequent bowel movements 15.78 10.55 6 85780 29533 79629069
Upper respiratory tract irritation 15.74 10.55 7 85779 256 79658346
Pneumonia pseudomonal 15.59 10.55 25 85761 5886 79652716
Arthritis 15.58 10.55 67 85719 114813 79543789
Occupational exposure to air contaminants 15.34 10.55 6 85780 158 79658444
Nausea 15.18 10.55 859 84927 956337 78702265
Extrapyramidal disorder 15.11 10.55 3 85783 22676 79635926
Drug eruption 15.05 10.55 15 85771 43920 79614682
Haematoma 15.05 10.55 102 85684 52093 79606509
Throat irritation 14.93 10.55 85 85701 40861 79617741
Bone marrow failure 14.76 10.55 20 85766 51087 79607515
Eye pruritus 14.56 10.55 52 85734 20518 79638084
Pupillary reflex impaired 14.54 10.55 18 85768 3335 79655267
Lactic acidosis 14.43 10.55 127 85659 70232 79588370
Toxic optic neuropathy 14.25 10.55 11 85775 1142 79657460
Abortion spontaneous 14.16 10.55 7 85779 29500 79629102
Dysgeusia 14.01 10.55 25 85761 57152 79601450
Oral herpes 13.98 10.55 6 85780 27448 79631154
Type 2 diabetes mellitus 13.81 10.55 107 85679 57015 79601587
Loss of consciousness 13.74 10.55 115 85671 167828 79490774
Liver injury 13.65 10.55 25 85761 56589 79602013
Inappropriate schedule of product administration 13.59 10.55 86 85700 133542 79525060
Supraventricular tachycardia 13.57 10.55 52 85734 21218 79637384
Illness 13.48 10.55 91 85695 46420 79612182
Chest pain 13.38 10.55 398 85388 281906 79376696
Pneumothorax 13.24 10.55 63 85723 28260 79630342
Pneumonia respiratory syncytial viral 13.15 10.55 13 85773 1877 79656725
Photophobia 13.10 10.55 3 85783 20525 79638077
Myalgia 13.08 10.55 132 85654 185509 79473093
Vascular parkinsonism 13.06 10.55 5 85781 124 79658478
Neuromyelitis optica spectrum disorder 13.01 10.55 10 85776 1032 79657570
Pulmonary embolism 12.98 10.55 258 85528 171396 79487206
Cytopenia 12.96 10.55 3 85783 20380 79638222
Underdose 12.95 10.55 10 85776 33141 79625461
Chronic sinusitis 12.94 10.55 37 85749 12989 79645613
Colitis ulcerative 12.92 10.55 11 85775 34731 79623871
Tracheitis 12.88 10.55 11 85775 1317 79657285
Injection site pruritus 12.77 10.55 16 85770 42267 79616335
Bursitis 12.56 10.55 12 85774 35832 79622770
Forced expiratory volume increased 12.44 10.55 4 85782 58 79658544
Grip strength decreased 12.44 10.55 4 85782 21865 79636737
Respiratory alkalosis 12.43 10.55 19 85767 4292 79654310
Haemophagocytic lymphohistiocytosis 12.41 10.55 4 85782 21833 79636769
Intentional self-injury 12.39 10.55 10 85776 32409 79626193
Stress cardiomyopathy 12.36 10.55 33 85753 11133 79647469
Leukopenia 12.36 10.55 74 85712 116439 79542163
Infantile haemangioma 12.32 10.55 3 85783 14 79658588
Drug hypersensitivity 12.29 10.55 237 85549 298679 79359923
Mucosal inflammation 12.25 10.55 41 85745 75539 79583063
Skin lesion 12.20 10.55 82 85704 41762 79616840
Infective exacerbation of chronic obstructive airways disease 12.16 10.55 15 85771 2769 79655833
Tongue exfoliation 12.14 10.55 5 85781 151 79658451
Pneumonia haemophilus 11.97 10.55 10 85776 1162 79657440
Bronchitis viral 11.89 10.55 10 85776 1173 79657429
Amaurosis 11.83 10.55 10 85776 1181 79657421
Coronary artery disease 11.83 10.55 115 85671 65359 79593243
Joint stiffness 11.77 10.55 16 85770 40814 79617788
Schizophrenia 11.77 10.55 40 85746 15400 79643202
Metastases to liver 11.77 10.55 8 85778 28306 79630296
Paraesthesia 11.76 10.55 127 85659 176196 79482406
Vital capacity decreased 11.74 10.55 12 85774 1804 79656798
Nephrocalcinosis 11.72 10.55 11 85775 1491 79657111
Product use in unapproved indication 11.72 10.55 194 85592 250165 79408437
Interstitial lung disease 11.69 10.55 72 85714 112528 79546074
Glycosylated haemoglobin decreased 11.64 10.55 8 85778 694 79657908
Cardiac disorder 11.63 10.55 115 85671 65642 79592960
Hyperlipidaemia 11.45 10.55 57 85729 26036 79632566
Neutrophil count decreased 11.44 10.55 57 85729 93902 79564700
Tracheal disorder 11.39 10.55 7 85779 502 79658100
Oropharyngeal pain 11.38 10.55 173 85613 109180 79549422
Pleural thickening 11.35 10.55 15 85771 2967 79655635
Diastolic hypotension 11.34 10.55 5 85781 179 79658423
Idiopathic pulmonary fibrosis 11.31 10.55 18 85768 4210 79654392
Hyperlactacidaemia 11.26 10.55 21 85765 5574 79653028
Pharyngeal mass 11.18 10.55 6 85780 332 79658270
Blood bicarbonate decreased 11.10 10.55 20 85766 5171 79653431
Injection related reaction 10.91 10.55 9 85777 1027 79657575
Expiratory reserve volume decreased 10.85 10.55 4 85782 89 79658513
Tumour hyperprogression 10.80 10.55 5 85781 201 79658401
Myelodysplastic syndrome 10.78 10.55 10 85776 30291 79628311
Serotonin syndrome 10.75 10.55 20 85766 45007 79613595
Oesophageal motility disorder 10.68 10.55 7 85779 561 79658041
Dry mouth 10.66 10.55 143 85643 87876 79570726
Pancreatitis 10.57 10.55 38 85748 68537 79590065
Hyperglycaemia 10.56 10.55 119 85667 70216 79588386

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R01AX03 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Other nasal preparations
ATC R03AL01 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC R03AL02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC R03BB01 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Anticholinergics
FDA MoA N0000175370 Cholinergic Antagonists
FDA EPC N0000175574 Anticholinergic
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:35523 bronchodilator
CHEBI has role CHEBI:48876 muscarinic antagonists
CHEBI has role CHEBI:53784 antispasmodics

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bronchospasm indication 4386001
Chronic obstructive lung disease indication 13645005 DOID:3083
Bronchitis indication 32398004 DOID:6132
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Pulmonary emphysema indication 87433001
Chronic Obstructive Pulmonary Disease with Bronchospasms indication
Asthma off-label use 195967001 DOID:2841
Asthma-chronic obstructive pulmonary disease overlap syndrome off-label use 10692761000119107
Ocular hypertension contraindication 4210003 DOID:9282
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Ketoacidosis contraindication 56051008
Metabolic acidosis contraindication 59455009
Diabetes mellitus contraindication 73211009 DOID:9351
Paradoxical bronchospasm contraindication 102578005
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Myocardial ischemia contraindication 414795007 DOID:3393
Congenital long QT syndrome contraindication 442917000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.24 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST Ki 9.29 WOMBAT-PK CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 8.82 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 9.18 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 8.77 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 9.31 WOMBAT-PK
Solute carrier family 22 member 2 Transporter IC50 4.82 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 9.11 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 9.54 CHEMBL
Muscarinic acetylcholine receptor M3 GPCR Ki 9.74 CHEMBL

External reference:

IDSource
4019791 VUID
N0000147880 NUI
D02212 KEGG_DRUG
66985-17-9 SECONDARY_CAS_RN
4019341 VANDF
4019791 VANDF
C0027235 UMLSCUI
CHEBI:5956 CHEBI
X8M PDB_CHEM_ID
CHEMBL1621597 ChEMBL_ID
DB00332 DRUGBANK_ID
CHEMBL1464005 ChEMBL_ID
CHEMBL2134724 ChEMBL_ID
D009241 MESH_DESCRIPTOR_UI
3746 PUBCHEM_CID
325 IUPHAR_LIGAND_ID
GR88G0I6UL UNII
1309404 RXNORM
4916 MMSL
6256 MMSL
d00265 MMSL
001750 NDDF
004943 NDDF
108624006 SNOMEDCT_US
372518007 SNOMEDCT_US
386881005 SNOMEDCT_US
725862005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0045 SPRAY 21 ug NASAL ANDA 3 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0045 SPRAY 21 ug NASAL ANDA 3 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0046 SPRAY 42 ug NASAL ANDA 16 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0046 SPRAY 42 ug NASAL ANDA 16 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0378-7970 SOLUTION 0.50 mg RESPIRATORY (INHALATION) ANDA 22 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0378-9671 SOLUTION 0.50 mg RESPIRATORY (INHALATION) ANDA 28 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0487-0201 SOLUTION 0.50 mg RESPIRATORY (INHALATION) ANDA 28 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0487-9801 SOLUTION 0.50 mg RESPIRATORY (INHALATION) ANDA 22 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0591-3798 SOLUTION 0.50 mg RESPIRATORY (INHALATION) ANDA 20 sections
Combivent Respimat HUMAN PRESCRIPTION DRUG LABEL 2 0597-0024 SPRAY, METERED 20 ug RESPIRATORY (INHALATION) NDA 27 sections
Combivent Respimat HUMAN PRESCRIPTION DRUG LABEL 2 0597-0024 SPRAY, METERED 20 ug RESPIRATORY (INHALATION) NDA 27 sections
Atrovent HFA HUMAN PRESCRIPTION DRUG LABEL 1 0597-0087 AEROSOL, METERED 17 ug RESPIRATORY (INHALATION) NDA 29 sections
Atrovent HFA HUMAN PRESCRIPTION DRUG LABEL 1 0597-0087 AEROSOL, METERED 17 ug RESPIRATORY (INHALATION) NDA 29 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0781-7146 SOLUTION 0.50 mg RESPIRATORY (INHALATION) ANDA 28 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0781-7157 SOLUTION 0.50 mg RESPIRATORY (INHALATION) ANDA 23 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 16714-526 SPRAY, METERED 21 ug NASAL ANDA 24 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 16714-527 SPRAY, METERED 42 ug NASAL ANDA 25 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 21695-911 SOLUTION 0.50 mg RESPIRATORY (INHALATION) ANDA 21 sections
Ipratropium bromide HUMAN PRESCRIPTION DRUG LABEL 1 24208-398 SPRAY, METERED 21 ug NASAL ANDA 27 sections
Ipratropium bromide HUMAN PRESCRIPTION DRUG LABEL 1 24208-398 SPRAY, METERED 21 ug NASAL ANDA 27 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 24208-399 SPRAY, METERED 42 ug NASAL ANDA 25 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 24208-399 SPRAY, METERED 42 ug NASAL ANDA 25 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 42254-041 SOLUTION 0.50 mg RESPIRATORY (INHALATION) ANDA 19 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 42254-355 SPRAY, METERED 42 ug NASAL ANDA 25 sections
Ipratropium Bromide Human Prescription Drug Label 1 47335-706 SOLUTION 0.50 mg RESPIRATORY (INHALATION) ANDA 19 sections
Ipratropium Bromide Human Prescription Drug Label 1 47335-706 SOLUTION 0.50 mg RESPIRATORY (INHALATION) ANDA 19 sections
Ipratropium Bromide and Albuterol Sulfate Human Prescription Drug Label 2 47335-756 SOLUTION 0.50 mg RESPIRATORY (INHALATION) ANDA 22 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 50090-0668 SOLUTION 0.50 mg RESPIRATORY (INHALATION) ANDA 21 sections
Ipratropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 50090-0668 SOLUTION 0.50 mg RESPIRATORY (INHALATION) ANDA 21 sections
AtroventHFA HUMAN PRESCRIPTION DRUG LABEL 1 50090-0961 AEROSOL, METERED 17 ug RESPIRATORY (INHALATION) NDA 25 sections