inositol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1444 87-89-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • inositol
  • myo-Inositol
  • cyclohexanehexol
  • cyclohexitol
  • inosital
  • inositene
  • inositina
  • mesoinositol
  • myoinosite
  • myoinositol
An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
  • Molecular weight: 180.16
  • Formula: C6H12O6
  • CLOGP: -0.12
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 6
  • TPSA: 121.38
  • ALOGS: 0.43
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Normal newborn 58.80 51.51 12 245 8329 63480436

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Needle fatigue 57.62 57.40 9 481 893 79743005

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA07 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:33284 nutrients
CHEBI has role CHEBI:64763 phosphatidylinositol-specific phospholipase C inhibitors
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:83056 Daphnia magna metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Hypoalphalipoproteinemia indication 190785000
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006
Pellagra indication 418186002 DOID:8457
Niacin deficiency indication 418279001
Slow Progression of Coronary Artery Disease indication
Myocardial Reinfarction Prevention indication
Hyperlipidemia off-label use 55822004 DOID:1168
Hypophosphatemia contraindication 4996001
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Acute cerebrovascular insufficiency contraindication 29322000
Low blood pressure contraindication 45007003
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Gout contraindication 90560007 DOID:13189
Liver function tests abnormal contraindication 166603001
Cerebrovascular accident contraindication 230690007
Arterial hemorrhage contraindication 234003006
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Acute coronary syndrome contraindication 394659003
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Cerebral infarction contraindication 432504007 DOID:3526




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.21 acidic
pKa2 13.31 acidic
pKa3 13.71 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017688 VUID
N0000146062 NUI
D08079 KEGG_DRUG
4017688 VANDF
C0021547 UMLSCUI
CHEBI:17268 CHEBI
INS PDB_CHEM_ID
CHEMBL1222251 ChEMBL_ID
DB13178 DRUGBANK_ID
D007294 MESH_DESCRIPTOR_UI
892 PUBCHEM_CID
10437 INN_ID
4L6452S749 UNII
5833 RXNORM
4879 MMSL
5751 MMSL
d00496 MMSL
002057 NDDF
108960004 SNOMEDCT_US
72164009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lipovite HUMAN PRESCRIPTION DRUG LABEL 13 70104-128 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
MIC B12 HUMAN PRESCRIPTION DRUG LABEL 4 70104-806 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
NEONATAL PLUS VITAMIN HUMAN PRESCRIPTION DRUG LABEL 17 70898-115 TABLET 5 mg ORAL unapproved drug other 9 sections