eritoran 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
toll-like receptor antagonists 1044 185955-34-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • eritoran tetrasodium
  • eritoran sodium
  • eritoran
  • Molecular weight: 1313.68
  • Formula: C66H126N2O19P2
  • CLOGP: 12
  • LIPINSKI: 4
  • HAC: 21
  • HDO: 7
  • TPSA: 293.63
  • ALOGS: -5.46
  • ROTB: 59

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.05 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.01 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 51 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.41 acidic
pKa2 4.63 acidic
pKa3 5.46 acidic
pKa4 8.63 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Toll-like receptor 4 Membrane receptor IC50 8.82 CHEMBL

External reference:

IDSource
D04043 KEGG_DRUG
185954-98-7 SECONDARY_CAS_RN
C1743645 UMLSCUI
E55 PDB_CHEM_ID
CHEMBL501259 ChEMBL_ID
CHEMBL2364546 ChEMBL_ID
CHEMBL3301672 ChEMBL_ID
CHEMBL2364541 ChEMBL_ID
DB04933 DRUGBANK_ID
C512420 MESH_SUPPLEMENTAL_RECORD_UI
4919 IUPHAR_LIGAND_ID
8562 INN_ID
551541VI0Y UNII
6912404 PUBCHEM_CID

Pharmaceutical products:

None