||A thymus hormone polypeptide found in thymosin fraction 5 (a crude thymus gland extract) but now produced by synthesis. It is used alone or with interferon as an immunomodulator for the treatment of CHRONIC HEPATITIS B and HEPATITIS C. Thymalfasin is also used for the treatment of chemotherapy-induced immunosuppression, and to enhance the efficacy of influenza and hepatitis B vaccines in immunocompromised patients.
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Drug search example:
Generic drug names, drug synonyms, trade names terms can be used to search for drugs.
Example search for Lipitor can query using either “Atorvastatin” or “Lipitor”.A comprehensive list of drug development codes and salt or ester forms
are also stored in the database and can be used as search terms, for example search for "rosuvastatin" the following terms can be used: "rosuvastatin calcium" or "ZD4522".
Disease search example:
Supported disease terms are SNOMED-CT and OMOP vocabulary terms. Disease annotations for drugs approved before 2012 originate from OMOP vocabulary mappings. For drugs approved after 2012 disease annotations are extracted manually from approved drug labels and mapped to SNOMED-CT concepts.
Example search for “Chronic Hepatitis
returns the list of antiviral
indicated to treat “Chronic Hepatitis C” followed by drugs
contra-indicated in hepatitis C.
Target search example:
Supported target search terms are HUGO gene symbols, Uniprot accessions and target names, and Swissprot identifiers.
Example search for drugs targeting Mu-type opioid receptor can be run using either of the
terms: “OPRM1”, P35372, “OPRM
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Pharmacologic action search example:
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Ranked result list is annotated with 4 level ranking system ordered from highest to lowest:
A - query term matched drug name or synonyms, mechanism of action target, or drug indication.
B - query term matched disease term in drug contraindications or off-label uses, targets listed in drug bioactivity profiles (not MoA targets), or pharmacologic action descriptions.
C - query term matched short drug description text.
D - query term matched full text in FDA drug labels.