Voltage-dependent L-type calcium channel subunit alpha-1D

Description:

Description
  • Accession: Q01668
  • Swissprot: CAC1D_HUMAN
  • Organism: Homo sapiens
  • Gene: CACNA1D
  • Target class: Ion channel

Drug Relations:

(S)-nicardipine
S-enantiomer of nicardipine is a calcium entry blocker (slow channel blocker or calcium ion antagonist) which inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle without changing serum calcium concentrations Bioactivity details MOA
(S)-nitrendipine
Bioactivity details MOA
amlodipine
A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION. Bioactivity details MOA
aranidipine
Bioactivity details MOA
azelnidipine
Bioactivity details MOA
barnidipine
Bioactivity details MOA
benidipine
Bioactivity details MOA
bepridil
A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. Bioactivity details MOA
cilnidipine
has excitatory & inhibitory action on the Ca+ channels in the rabbit basilar artery; structure given in first source; RN given is for (+-) isomer Bioactivity details MOA
clevidipine
a calcium channel blocker and antihypertensive agent Bioactivity details MOA
dexniguldipine
Bioactivity details MOA
efonidipine
Bioactivity details MOA
felodipine
A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. Bioactivity details MOA
isradipine
A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure. Bioactivity details MOA
lacidipine
Bioactivity details MOA
lercanidipine
Bioactivity details MOA
levamlodipine
used to treat angina and hypertension Bioactivity details MOA
manidipine
Bioactivity details MOA
nicardipine
A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. Bioactivity details MOA
nifedipine
A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure. Bioactivity details MOA
nilvadipine
Bioactivity details MOA
nimodipine
A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure. Bioactivity details MOA
nisoldipine
A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina. Bioactivity details MOA
nitrendipine
A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive. Bioactivity details MOA