3-hydroxy-3-methylglutaryl-coenzyme A reductase


  • Accession: Q01237
  • Swissprot: HMDH_MOUSE
  • Organism: Mus musculus
  • Gene: Hmgcr
  • Target class: Enzyme

Drug Relations:

A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. Bioactivity details MOA