Tubulin beta-4B chain

Description:

Description
  • Accession: P68371
  • Swissprot: TBB4B_HUMAN
  • Organism: Homo sapiens
  • Gene: TUBB4B
  • Target class: Structural

Drug Relations:

brentuximab vedotin
a CD30-directed antibody-drug conjugate consisting of three components: the chimeric IgG1 antibody cAC10, specific for human CD30, the microtubule disrupting agent MMAE, and a protease-cleavable linker that covalently attaches MMAE to cAC10 Bioactivity details MOA
cabazitaxel
a microtubule inhibitor, cabazitaxel binds to tubulin and promotes its assembly into microtubules while simultaneously inhibiting disassembly. This leads to the stabilization of microtubules, which results in the inhibition of mitotic and interphase cellular functions Bioactivity details MOA
docetaxel
semisynthetic analog of taxol Bioactivity details MOA
eribulin
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase and sequesters tubulin into nonproductive aggregates. Eribulin exerts its effects via a tubulin-based antimitotic mechanism leading to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage. In addition, eribulin treatment of human breast cancer cells caused changes in morphology and gene expression as well as decreased migration and invasiveness in vitro. In mouse xenograft models of human breast cancer, eribulin treatment was associated with increased vascular perfusion and permeability in the tumor cores, resulting in reduced tumor hypoxia, and changes in the expression of genes in tumor specimens associated with a change in phenotype. Bioactivity details MOA
ixabepilone
has antineoplastic activity; epothilone B lactam analogue that induces cell cycle arrest at the G(2)-M phase Bioactivity details MOA
paclitaxel
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death. Bioactivity details MOA
trastuzumab emtansine
designed to deliver antimicrotubule agent DM1 to HER2-positive cells; do not confuse ado-trastuzumab emtansine with trastuzumab, which has the brand name Herceptin Bioactivity details MOA
vinblastine
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) Bioactivity details MOA
vincristine
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.) Bioactivity details MOA
vinflunine
inhibits tubulin assembly Bioactivity details MOA
vinorelbine
Bioactivity details MOA
anhydrovinblastine
Bioactivity details MOA
colchicine
A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE). Bioactivity details MOA
podophyllotoxin
A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. Bioactivity details MOA