Growth factor receptor-bound protein 2


  • Accession: P62993
  • Swissprot: GRB2_HUMAN
  • Organism: Homo sapiens
  • Gene: GRB2
  • Target class: Cytosolic other

Drug Relations:

A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015) Bioactivity details MOA