Retinoic acid receptor RXR-gamma


  • Accession: P48443
  • Swissprot: RXRG_HUMAN
  • Organism: Homo sapiens
  • Gene: RXRG
  • Target class: Nuclear hormone receptor

Drug Relations:

an RXR agonist Bioactivity details MOA
a retinoid X receptor (RXR) selective agonist Bioactivity details MOA
An oral retinoid used in the treatment of keratotic genodermatosis, lichen planus, and psoriasis. Beneficial effects have also been claimed in the prophylaxis of epithelial neoplasia. The compound may be teratogenic. Bioactivity details MOA
An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE). Bioactivity details MOA