Glutamate receptor 1


  • Accession: P42261
  • Swissprot: GRIA1_HUMAN
  • Organism: Homo sapiens
  • Gene: GRIA1
  • Target class: Ion channel

Drug Relations:

A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors. Bioactivity details MOA
a non-competitive AMPA glutamate receptor antagonist indicated as adjunctive therapy for the treatment of seizures Bioactivity details MOA
an anticonvulsant drug Bioactivity details MOA
inhibits the desensitization of AMPA-type receptors; structure Bioactivity details MOA
glutamic acid
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. Bioactivity details MOA
kainic acid
(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose. Bioactivity details MOA